From 1e0110ca049591edaf369cd68ba5a40b752a96e0 Mon Sep 17 00:00:00 2001 From: Peter Yu Date: Wed, 21 Jan 2026 20:27:11 -0500 Subject: [PATCH] Add web scrapers and faculty data for Medicine, History, and Physics - Add History_WebScraper.py, Web_Scraper.py, webscraper_MED.py - Add faculty/lab data JSON files for Yale departments - Add physics people CSV and JSON data --- faculty_data.json | 4466 +++++++++ web-scraper/History_WebScraper.py | 147 + web-scraper/Web_Scraper.py | 78 + web-scraper/testscrape.py | 121 + web-scraper/webscraper_MED.py | 161 + yale_history_faculty.json | 436 + yale_medicine_labs.json | 14875 ++++++++++++++++++++++++++++ yale_physics_faculty_10.json | 133 + yale_physics_people.csv | 1 + yale_physics_people.json | 3282 ++++++ yale_physics_people_10.json | 143 + 11 files changed, 23843 insertions(+) create mode 100644 faculty_data.json create mode 100644 web-scraper/History_WebScraper.py create mode 100644 web-scraper/Web_Scraper.py create mode 100644 web-scraper/testscrape.py create mode 100644 web-scraper/webscraper_MED.py create mode 100644 yale_history_faculty.json create mode 100644 yale_medicine_labs.json create mode 100644 yale_physics_faculty_10.json create mode 100644 yale_physics_people.csv create mode 100644 yale_physics_people.json create mode 100644 yale_physics_people_10.json diff --git a/faculty_data.json b/faculty_data.json new file mode 100644 index 0000000..a17fcb0 --- /dev/null +++ b/faculty_data.json @@ -0,0 +1,4466 @@ +[ + { + "name": "Michael Abbott", + "profile_link": "https://physics.yale.edu/people/michael-abbott", + "title": "Associate Research Scientist", + "office": "YSB-C164", + "email": "michael.abbott@yale.edu", + "phones": [], + "website": "https://machtagroup.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3675-1733943781.png?itok=kIXQrctH", + "field_of_study": "BiophysicsTheorist", + "profile_bio": null, + "website_text": "Who we are The group’s research focuses on understanding how biological systems operate using approaches from theoretical physics.  We use statistical physics to understand the structure and function of biological membranes, which experiments have shown operate close to a demixing critical point in the Ising universality class.  We also use tools from information theory to place physical bounds on the ability of organisms to function that arise from their limited ability to measure their environment and from their limited energy budget. We are in the Department of Physics and the QBio Institute at Yale University, located physically in the Yale Science Building (YSB) in the QBio area, C level. Selected Publications Escherichia coli chemotaxis is information limited .  Henry H. Mattingly, Keita Kamino, Benjamin B. Machta, Thierry Emonet. Nature Physics 17 , 1426–1431 (2021). Surface densities prewet a near critical membrane .  Mason Rouches, Sarah L. Veatch, Benjamin B. Machta . Proceedings of the National Academy of Sciences 118 (40) e2103401118 (2021). Irriversibility in dynamical phases and transitions. Daniel S. Seara, Benjamin B. Machta , Michael S. Murrell. Nature Communications 12 392 (2021) pdf Energy Dissipation Bounds in Autonomous Thermodynamic Systems. Samuel J. Bryant, Benjamin B. Machta. Proceedings of the National Academy of Sciences 117 (7), 3478-3483 (2020), pdf Maximizing the information learned from finite data selects a simple model .  Henry H. Mattingly, Mark K. Transtrum, Michael C. Abbott, Benjamin B. Machta. Proceedings of the National Academy of Sciences 115 (8) 1760-1765 (2018), pdf" + }, + { + "name": "Maren Adnee", + "profile_link": "https://physics.yale.edu/people/maren-adnee", + "title": "Graduate School Student", + "office": "maren.adnee@yale.edu", + "email": "maren.adnee@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5455-1750858135.png?itok=S8jFwVed", + "field_of_study": "", + "profile_bio": "I am interested in the development of experimental and analytical methods that can untangle complex interactions to reveal underlying patterns, especially as applied to correlated systems and emergent phenomena in condensed matter physics.", + "website_text": null + }, + { + "name": "Charles Ahn", + "profile_link": "https://physics.yale.edu/people/charles-ahn", + "title": "John C. Malone Professor of Applied Physics and Professor of Mechanical Engineering and of Physics", + "office": "BCT 301", + "email": "charles.ahn@yale.edu", + "phones": [ + "203-432-6421", + "203-432-4283" + ], + "website": "http://ahnlab.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-296-1571322499.jpg?itok=VwvtCSrY", + "field_of_study": "Condensed Matter PhysicsExperimentalistGrowth and Characterization of Oxides, Crystalline Oxides on Semiconductors, Ferroelectric Coupling to Conducting Channels, Picoscale Engineering of Correlated Advanced Nanomaterials, Synchrotron Structures of Interfaces, X-ray Diffraction and Applications", + "profile_bio": "The research group focuses on the fabrication and the study of the physical properties of novel complex oxide materials using advanced growth and characterization techniques, including molecular beam epitaxy and synchrotron x-ray scattering techniques.  Current interests include the physics and technology of multifunctional oxides, nanofabrication and electronic writing using scanning probe microscopies, electronic control of complex order parameters in correlated oxides, and development of nonvolatile logic switches for post-CMOS computing paradigms.", + "website_text": "Welcome to Ahn Lab The research group focuses on the fabrication and the study of the physical properties of novel complex oxide materials using advanced growth and characterization techniques, including molecular beam epitaxy and synchrotron x-ray scattering techniques.  Current interests include the physics and technology of multifunctional oxides, nanofabrication and electronic writing using scanning probe microscopies, electronic control of complex order parameters in correlated oxides, and development of nonvolatile logic switches for post-CMOS computing paradigms." + }, + { + "name": "Eun-Joo Ahn", + "profile_link": "https://physics.yale.edu/people/eun-joo-ahn", + "title": "Lecturer, Presidential Visiting Fellow, RITM Faculty Fellow", + "office": "WL 237", + "email": "eun-joo.ahn@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4843-1734115482.jpg?itok=j3CeuME7", + "field_of_study": "Asian Americans and STEM", + "profile_bio": "I am examining the history of post Second World War transnational physics involving Asian American physicists, and on the history of Mount Wilson Observatory. As an astrophysicist, I have worked in composition determination and hadronic interaction model of ultra high energy cosmic rays. I was part of the Pierre Auger Collaboration.", + "website_text": null + }, + { + "name": "Yoram Alhassid", + "profile_link": "https://physics.yale.edu/people/yoram-alhassid", + "title": "Frederick Phineas Rose Professor of Physics", + "office": "SPL 50", + "email": "yoram.alhassid@yale.edu", + "phones": [ + "203-432-6922" + ], + "website": "http://alhassidgroup.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-17-1754570646.jpg?itok=PyR6fmnF", + "field_of_study": "Nuclear PhysicsTheoristThe nuclear many-body problem;Femtoscience and nanoscience: nuclei quantum dots and nanoparticles; Cold atomic Fermi gases.", + "profile_bio": "In his nuclear theory research, Professor Alhassid is addressing a major challenge: the microscopic derivation of nuclear properties from underlying effective interactions. Knowledge of nuclear properties is important for understanding astrophysical processes such as nucleosynthesis and supernovas, and for interpreting results expected from new radioactive beam facilities. The configuration-interaction (CI) shell model is a suitable model for such microscopic studies as it includes both shell effects and correlations.  However, combinatorial growth of the dimension of the many-particle space hinders application of the CI shell model in mid-mass and heavy nuclei. Alhassid’s group is developing sophisticated quantum Monte Carlo methods to calculate nuclear properties in model spaces that are many orders of magnitude larger than those that can be treated by conventional methods [1].  In particular, the group pioneered the development and application of the auxiliary-field Monte Carlo approach as the state-of-the-art method for microscopic calculation of the nuclear level density, the most important statistical nuclear property [2].  A recent breakthrough is a method to calculate the ground-state energy of an odd particle-number system that circumvents the sign problem introduced by the projection on an odd number of particles [3]. Methods and concepts originating in nuclear theory have contributed to our understanding of mesoscopic systems and nanostructures in which finite-size effects are important, such as quantum dots and nano-sized metallic grains. Alhassid’s group has been on the forefront of such interdisciplinary studies. In particular, Alhassid and collaborators developed a statistical theory of quantum dots that explains the mescoscopic fluctuations of the conductance in terms of the underlying signatures of chaos in the single-particle electronic wavefunctions [4,5]. The group’s current focus in this area is on the interplay between single-particle chaos and many-body correlations. A fascinating example is pairing correlations in nano-scale metallic grains whose linear size is smaller than a few nanometers. At this scale, fluctuations in the order parameter become important and BCS theory breaks down [6].  This regime is common to nanoparticles and nuclei [7], even though their gaps differ by six orders of magnitude. Another research subject is cold atomic Fermi gases. Strongly interacting Fermi systems occur in different areas of nature, such as nuclei, quark matter, and neutron stars, and present an important theoretical challenge. Cold atomic Fermi gases provide a clean paradigm for such systems. They can be experimentally probed, and their interactions can be tuned to a wide range of physical regimes, including the Bose-Einstein condensate (BEC), the BCS regime and a nonperturbative unitary regime in which the interaction is strongest and corresponds to an infinite scattering length. The cold atom studies of Alhassid’s group utilize the CI method.  Recent advance include a new effective interaction that dramatically improves the convergence of many-particle energies [8] and a description of the nature of superfluidity in the finite-size unitary gas [9].", + "website_text": "Welcome to the homepage of the Alhassid research group at Yale University. We study theoretical physics, particularly finite-size correlated quantum many-body systems.  Our research program spans three main directions: the nuclear many-body problem, mesoscopic physics and nanoscience, and cold atomic Fermi gases. About People Recent News The nuclear many-body problem Femtoscience and nanoscience: nuclei, quantum dots and nanoparticles Cold atomic Fermi gases Recent Talks Publications" + }, + { + "name": "Thomas Appelquist", + "profile_link": "https://physics.yale.edu/people/thomas-appelquist", + "title": "Eugene Higgins Professor of Physics", + "office": "SPL 68D", + "email": "thomas.appelquist@yale.edu", + "phones": [ + "203-432-6969" + ], + "website": "http://het.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-18-1571322557.jpg?itok=1xi7znvY", + "field_of_study": "Particle PhysicsTheorist", + "profile_bio": null, + "website_text": "Welcome Our group works on diverse topics in theoretical high energy physics, including physics beyond the Standard Model, field theory, quantum chromodynamics, conformal bootstrap, and early universe physics." + }, + { + "name": "Jenn Arnone", + "profile_link": "https://physics.yale.edu/people/jenn-arnone", + "title": "Senior Administrative Assistant", + "office": "WL 220", + "email": "jennifer.arnone@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4890-1702478622.jpg?itok=2bo-Yj6U", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Mesut Arslandok", + "profile_link": "https://physics.yale.edu/people/mesut-arslandok", + "title": "Associate Research Scientist", + "office": "WLW-303 & CERN, 1211 Geneva 23, Switzerland", + "email": "mesut.arslandok@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3678-1612792711.png?itok=uaJeJ-HC", + "field_of_study": "Relativistic Heavy Ions", + "profile_bio": "I have been involved in the ALICE experiment at CERN since 2010. My research covers many aspects of experimental heavy-ion physics such as detector physics and operation, software development, simulations and physics analysis. I have been serving as the convener of the physics analysis group on even-by-event fluctuations since 2019, and carrying out several physics analyses on this field such as conserved charge, net-proton and particle ratio fluctuations. These analyses are expected to shed light on the understanding of an extreme phase of matter - called the quark-gluon plasma (QGP) - created in high-energy heavy-ion collisions. This primordial state of matter is thought to have existed for the first few millionths of a second after the Big Bang. The QGP created in these collisions undergoes a transition to the hadronic phase, after it expands and cools down. Event-by-event fluctuations are very sensitive to this phase transition, therefore it also plays a significant role within the energy scan programs of the CERN SPS and RHIC. Moreover, as a member of the TPC (Time Projection Chamber) detector group, I have been taking part in the operation of the TPC and working on the calibration and optimization of the TPC particle identification (PID) performance in both MWPC (Multi-Wire Proportional Chambers) and GEM (Gas Electron Multiplier) based technologies. Furthermore, I am actively involved in the next-generation multi-purpose detector project at the LHC which is a follow-up to the present ALICE experiment (arXiv:1902.01211 [physics.ins-det]).", + "website_text": null + }, + { + "name": "Jeffery Ashenfelter", + "profile_link": "https://physics.yale.edu/people/jeffery-ashenfelter", + "title": "Director Wright Lab Operations", + "office": "WL 220D", + "email": "jeffery.ashenfelter@yale.edu", + "phones": [ + "203-432-5755" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-304-1738171101.jpg?itok=TLFhfY-s", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Chris Atchley", + "profile_link": "https://physics.yale.edu/people/chris-atchley", + "title": "Client Technologies Administrator II, FAS and SEAS", + "office": "SPL 65L", + "email": "christopher.atchley@yale.edu", + "phones": [ + "+1 (203) 4329000" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5296-1738170296.png?itok=LddgT5km", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Braedyn Au", + "profile_link": "https://physics.yale.edu/people/braedyn-au", + "title": "Graduate School Student", + "office": "braedyn.au@yale.edu", + "email": "braedyn.au@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3854-1666972197.jpg?itok=i0cWQpMe", + "field_of_study": "BiophysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Jackie Baeza-Rubio", + "profile_link": "https://physics.yale.edu/people/jackie-baeza-rubio", + "title": "Graduate School Student", + "office": "WLW 322D", + "email": "jackie.baeza-rubio@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4767-1734116026.jpg?itok=RcMVXImE", + "field_of_study": "Neutrinos & Fundamental Symmetries Atomic, Molecular, & Optical PhysicsExperimentalistSIMPLE, QuIPS", + "profile_bio": null, + "website_text": null + }, + { + "name": "Xiran Bai", + "profile_link": "https://physics.yale.edu/people/xiran-bai", + "title": "Graduate School Student", + "office": "WLC 254A", + "email": "xiran.bai@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3514-1590606927.jpg?itok=tWcBy57-", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Charles Bailyn", + "profile_link": "https://physics.yale.edu/people/charles-bailyn", + "title": "A. Bartlett Giamatti Professor of Astronomy and Physics", + "office": "KT 531", + "email": "charles.bailyn@yale.edu", + "phones": [ + "203-432-3022" + ], + "website": "http://www.astro.yale.edu/bailyn/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-104-1759848741.png?itok=WlZ15KNO", + "field_of_study": "Astrophysics & CosmologyExperimentalistObservations of stellar mass blackholes, SMARTS consortium", + "profile_bio": "My research focusses on observations of stellar mass black holes and related topics. I serve as the Principal Scientist of the SMARTS consortium , and President of the Board of WIYN Inc.", + "website_text": null + }, + { + "name": "Keith Baker", + "profile_link": "https://physics.yale.edu/people/keith-baker", + "title": "D. Allan Bromley Professor of Physics", + "office": "WL 211", + "email": "oliver.baker@yale.edu", + "phones": [ + "203-432-3374" + ], + "website": "http://hep.yale.edu/people/oliver-baker", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-19-1666298384.jpg?itok=JUpJwgeV", + "field_of_study": "Particle PhysicsExperimentalistATLAS, Axions, Hidden Sector Photons, Yale Microwave Cavity Experiment (YMCE)", + "profile_bio": "Experimental particle physics research in the ATLAS collaboration at the LHC. Built the detectors and carried out ML analysis in the Higgs boson discovery. Originated ATLAS analysis search for Dark Sector (BSM) phenomena in exotic decays of the Higgs boson to four leptons. Co-pioneered LHC research Quantum Information Science (quantum entanglement, entanglement entropy) in proton-proton collisions.", + "website_text": "Professor of Physics" + }, + { + "name": "Charles Baltay", + "profile_link": "https://physics.yale.edu/people/charles-baltay", + "title": "Eugene Higgins Professor Emeritus of Physics", + "office": "WL 213", + "email": "charles.baltay@yale.edu", + "phones": [ + "+1 (203) 432-3386" + ], + "website": "http://hep.yale.edu/people/charles-baltay", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-20-1571322642.jpg?itok=oxRqRncn", + "field_of_study": "Astrophysics & Cosmology; Particle PhysicsExperimentalistDark Energy Spectroscopic Instrument (DESI), Quasar Equatorial Survey Team (QUEST) Camera", + "profile_bio": "I am an experimentalist concentrating on fundamental issues, be that in particle physics, astrophysics, or cosmology. In the nineteen sixties used the exposures of various Bubble Chambers at Brookhaven and SLAC to antiproton, kaon, and pion beams to study the then recently discovered strongly decaying particle states (resonances) and CP violation in eta meson and kaon decays. In the nineteen seventies studied neutrino interactions in the Fermilab 15 foot bubble chamber measuring purely leptonic neutral currents to measure the Weinberg angle and find strange particle production as evidence of charm particle decays. In the nineteen eighties and nineties severed as co-spokesman of the SLC experiment at the SLAC Linear Collider (the SLC) to carry out precision electroweak measurements via Z o production and decays. More recently I have been working in Astrophysics and Cosmology, studying the nature of Dark Energy, the mysterious component that makes up three quarters of our universe, yet we know essentially nothing about it.  We do this both from ground-based telescopes in the Andes in Chile in South America, and from a space mission, formerly WFIRST,  now the Nancy Grace Roman Space Telescope, via the study of distant Supernova explosion events. For Fun Skiing and sailing with a large family.", + "website_text": "Eugene Higgins Professor of Physics and Professor of Astronomy" + }, + { + "name": "Sam Banks", + "profile_link": "https://physics.yale.edu/people/sam-banks", + "title": "Graduate School Student", + "office": "YSB", + "email": "sam.banks@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4768-1693935654.png?itok=_OvgUgSe", + "field_of_study": "QBio", + "profile_bio": null, + "website_text": null + }, + { + "name": "Sean Barrett", + "profile_link": "https://physics.yale.edu/people/sean-barrett", + "title": "Professor of Physics and Applied Physics", + "office": "SPL 24", + "email": "sean.barrett@yale.edu", + "phones": [ + "203-432-6928" + ], + "website": "http://opnmr.physics.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-21-1355769009.jpg?itok=uFtbpC3P", + "field_of_study": "Condensed Matter PhysicsExperimentalistQuadratic Echo Line-Narrowing, Imaging Hard and Soft Solids, Advancing Spectral Reconstruction with Undersampled Data Sets, Custom NMR/MRI Probe Design and Construction", + "profile_bio": "Experimental condensed matter physics; using OPNMR to study electron-doped GaAs quantum wells in the presence of large magnetic fields.", + "website_text": "Welcome to the Barrett Lab at the Physics Department at Yale! Our lab pursues research projects in solid-state nuclear magnetic resonance (NMR), magnetic resonance imaging (MRI) of solids, as well as sparse-sampling and Fourier reconstruction algorithms. Thus, the the research projects involve the theoretical and experimental development of pulse sequences, custom NMR and MRI probes design and machining, as well as developing of algorithms for sparse data sets and image reconstruction. The lab has active cross-departmental collaborations with the Department of Chemistry, Department of Engineering and the Magnetic Resonance Research Imaging Center at Yale as well as internationally with the Weizmann Institute of Science. Happy browsing!" + }, + { + "name": "Jeremy Barrios", + "profile_link": "https://physics.yale.edu/people/jeremy-barrios", + "title": "Graduate School Student", + "office": "jeremy.barrios@yale.edu", + "email": "jeremy.barrios@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4769-1733943823.png?itok=AbIOpOj2", + "field_of_study": "Biophysics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Roman Baskov", + "profile_link": "https://physics.yale.edu/people/roman-baskov", + "title": "Postdoctoral Associate", + "office": "YQI 4th Floor", + "email": "roman.baskov@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5482-1749583811.jpg?itok=nuynR0Z8", + "field_of_study": "Condensed Matter PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Eunice Beato", + "profile_link": "https://physics.yale.edu/people/eunice-beato", + "title": "Graduate School Student", + "office": "eunice.beato@yale.edu", + "email": "eunice.beato@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4723-1749844431.jpg?itok=TFCpQYgX", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Helena Beeloo", + "profile_link": "https://physics.yale.edu/people/helena-beeloo", + "title": "Graduate School Student", + "office": "helena.beeloo@yale.edu", + "email": "helena.beeloo@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5456-1751394006.jpg?itok=36kSVfxT", + "field_of_study": "", + "profile_bio": "Research Interests: Radiation Pressure and Quantum Optomechanics", + "website_text": null + }, + { + "name": "Jose Betancourt Valencia", + "profile_link": "https://physics.yale.edu/people/jose-betancourt-valencia", + "title": "Graduate School Student", + "office": "YSB", + "email": "jose.betancourtvalencia@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4770-1693935861.png?itok=wVsMX7lZ", + "field_of_study": "BiophysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Joerg Bewersdorf", + "profile_link": "https://physics.yale.edu/people/joerg-bewersdorf", + "title": "Harvey and Kate Cushing Professor of Cell Biology", + "office": "SHM I-Wing, E91", + "email": "joerg.bewersdorf@yale.edu", + "phones": [ + "+1 (203) 737-5704" + ], + "website": "https://bewersdorflab.yale.edu", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3946-1636654197.jpg?itok=4T8yPkYT", + "field_of_study": "BiophysicsExperimentalistOptical instrumentation development for biological imaging: Nanoscopy, Localization Microscopy, PanExM, STED microscopy", + "profile_bio": "Visualizing 3D structure and dynamics at the molecular scale is a current and critical need in biomedical research. Many sub-cellular features, for example the morphology of many organelles or the 3D organization of chromatin, cannot be resolved by standard light microscopy. Improving the resolution of light microscopy has therefore been an urgent need of biological research for many decades. Today, several methods achieve sub-100 nm resolution by taking advantage of reversible or irreversible photo-physical switching properties of fluorescent markers. Our research group in the Department of Cell Biology at Yale University School of Medicine is developing new fluorescence microscopy techniques with spatial and/or temporal resolutions going far beyond current technology and also applying them to a diverse set of biological questions. Specialized Terms: Super-resolution fluorescence microscopy Extensive Research Description Our laboratory develops super-resolution Stimulated Emission Depletion (STED) microscopy, Single-molecule Localization Microscopy (FPALM/PALM/STORM/PAINT, etc.) and pan-Expansion Microscopy (pan-ExM) techniques. We are actively developing to improve the capabilities (speed, 3D resolution, robustness, multicolor labeling) of these imaging techniques to expand the application range of super-resolution microscopy. In collaboration with a diverse set of research groups at Yale University and outside, we apply our new instruments to current biomedical questions, in particular related to the endoplasmic reticulum, the Golgi complex, the cell nucleus and cytokinesis. Research Interests Cell Nucleus; Endoplasmic Reticulum; Microscopy, Fluorescence; Microscopy, Confocal; Cellular Structures", + "website_text": null + }, + { + "name": "Karan Bhatia", + "profile_link": "https://physics.yale.edu/people/karan-bhatia", + "title": "Graduate School Student", + "office": "karan.bhatia@yale.edu", + "email": "karan.bhatia@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3194-1757599555.png?itok=en2bhUVw", + "field_of_study": "Condensed Matter PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Nathan Borak", + "profile_link": "https://physics.yale.edu/people/nathan-borak", + "title": "Graduate School Student", + "office": "WL", + "email": "nathan.borak@yale.edu", + "phones": [ + "203-436-4822" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3195-1535123794.jpg?itok=7Ds71oqC", + "field_of_study": "Particle PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Igor Brandao Cavalcanti Moreira", + "profile_link": "https://physics.yale.edu/people/igor-brandao-cavalcanti-moreira", + "title": "Graduate School Student", + "office": "WLW 327", + "email": "igor.brandao@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4179-1657034299.jpg?itok=elHDCc4K", + "field_of_study": "AMOExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Naomi Brandt", + "profile_link": "https://physics.yale.edu/people/naomi-brandt", + "title": "Graduate School Student", + "office": "YSB", + "email": "naomi.brandt@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3856-1630415628.jpg?itok=ZNDnWJHJ", + "field_of_study": "Biological Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Charles Brown", + "profile_link": "https://physics.yale.edu/people/charles-brown", + "title": "Assistant Professor of Physics", + "office": "SPL 68B", + "email": "charles.d.brown@yale.edu", + "phones": [], + "website": "https://brownlab.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-396-1646167435.jpg?itok=d_1LPX6I", + "field_of_study": "Atomic, Molecular, and Optical PhysicsExperimentalistUltracold atomic physics in optical lattices", + "profile_bio": "Professor Brown aims to study single-, few-, and many-body quantum physics by conducting quantum simulation experiments. Quantum simulations are realizations of complex quantum systems for the purpose of understanding their ordered phases and dynamics. His group traps ultracold atoms in optical lattice potentials (an ultracold atom quantum simulator), which is the spatially periodic potential the atoms experience in the intensity standing wave of several intersecting lasers. In doing so, the Brown group aims to learn about exotic order phases of ultracold bosons and fermions in optical lattices, how transport works in lattices with unusual geometry (e.g., a “lattice” that lacks translational symmetry), and what role topology plays in the quantum behavior of bosons and fermions in such unusual lattices", + "website_text": null + }, + { + "name": "Kangle Cai", + "profile_link": "https://physics.yale.edu/people/kangle-cai", + "title": "Graduate School Student", + "office": "SPL 77", + "email": "kangle.cai@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3858-1630415723.jpg?itok=wwmNEjaJ", + "field_of_study": "Condensed Matter PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Helen Caines", + "profile_link": "https://physics.yale.edu/people/helen-caines", + "title": "Horace D. Taft (B.A. 1949) Professor of Physics / Director of Graduate Studies", + "office": "Wright Lab-W 306", + "email": "helen.caines@yale.edu", + "phones": [ + "203-432-5831", + "203-432-8926" + ], + "website": "https://wlab.yale.edu/people/helen-caines", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-22-1666370627.jpg?itok=SVzl19MR", + "field_of_study": "Nuclear PhysicsExperimentalistALICE, STAR, ePIC", + "profile_bio": null, + "website_text": null + }, + { + "name": "Hui Cao", + "profile_link": "https://physics.yale.edu/people/hui-cao", + "title": "John C. Malone Professor of Applied Physics, Professor of Physics, Professor of Electrical Engineering", + "office": "BCT 309", + "email": "hui.cao@yale.edu", + "phones": [ + "203-432-0683" + ], + "website": "http://www.eng.yale.edu/caolab", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-105-1575476213.jpg?itok=doH9dLFN", + "field_of_study": "Condensed Matter PhysicsExperimentalistCoherent control of light transport and absorption, Random lasers, Spatial coherence engineering of lasers, Speckle-based spectrometers", + "profile_bio": "Hui Cao’s research interests and activities are in the areas of mesoscopic physics, complex photonic materials and devices, nanophotonics, and biophotonics. She has conducted experimental studies on unconventional lasers including random lasers and chaotic microcavity lasers, and found their applications in speckle-free imaging, multi-modality microscopy, and parallel random number generation. Another research focus of hers is coherent control of light transport in diffusive media and multimode fibers, with applications to deep-tissue imaging and endoscopy. Cao has also been creating and controlling complex light fields, and customizing the intensity statistics of laser speckle patterns for structured illumination microscopy. In addition to fundamental studies on complex, chaotic and disordered systems, she has harnessed disorder for photonic device applications, e.g., she invented a compact spectrometer based on a disordered photonic chip.", + "website_text": null + }, + { + "name": "Benjamin Capinski", + "profile_link": "https://physics.yale.edu/people/benjamin-capinski", + "title": "Graduate School Student", + "office": "benjamin.capinski@yale.edu", + "email": "benjamin.capinski@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5457-1754686427.png?itok=4q7LBUSO", + "field_of_study": "Atomic physics, quantum information, and photonicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "David Carcamo", + "profile_link": "https://physics.yale.edu/people/david-carcamo", + "title": "Graduate School Student", + "office": "YSB", + "email": "david.carcamo@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3859-1630415770.jpg?itok=nguLkeat", + "field_of_study": "BiophysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Carlotta Casi", + "profile_link": "https://physics.yale.edu/people/carlotta-casi", + "title": "Graduate School Student", + "office": "carlotta.casi@yale.edu", + "email": "carlotta.casi@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5100-1722263145.png?itok=OSseWE7I", + "field_of_study": "Particle PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Richard Casten", + "profile_link": "https://physics.yale.edu/people/richard-casten", + "title": "D. Allan Bromley Professor Emeritus of Physics", + "office": "WL 239", + "email": "richard.casten@yale.edu", + "phones": [ + "203-432-6174" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-23-1585151726.jpg?itok=Roh5Pfet", + "field_of_study": "Nuclear PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Eduardo Castro Munoz", + "profile_link": "https://physics.yale.edu/people/eduardo-castro-munoz", + "title": "Graduate School Student", + "office": "eduardo.castromunoz@yale.edu", + "email": "eduardo.castromunoz@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4771-1693935989.png?itok=9-ravhLj", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Flavio Cavanna", + "profile_link": "https://physics.yale.edu/people/flavio-cavanna", + "title": "Professor (Adjunct) of Physics", + "office": "FERMILAB and University of L’Aquila (It)", + "email": "flavio.cavanna@yale.edu", + "phones": [], + "website": "http://hep.yale.edu/people/flavio-cavanna", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-755-1738172109.jpg?itok=_gK2HmoG", + "field_of_study": "", + "profile_bio": null, + "website_text": "Professor (Adjunct) of Physics" + }, + { + "name": "Katie Chang", + "profile_link": "https://physics.yale.edu/people/katie-chang", + "title": "Graduate School Student", + "office": "YQI 408C", + "email": "katie.chang@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3860-1667491320.jpg?itok=CDjdlaAQ", + "field_of_study": "Quantum Information Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "William Chang", + "profile_link": "https://physics.yale.edu/people/william-chang", + "title": "Graduate School Student", + "office": "william.chang@yale.edu", + "email": "william.chang@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5135-1724335784.png?itok=62V1WEnX", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Derek Chen", + "profile_link": "https://physics.yale.edu/people/derek-chen", + "title": "Graduate School Student", + "office": "SPL 11", + "email": "derek.chen.jc3757@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3515-1588171950.png?itok=xix3C06N", + "field_of_study": "Atomic & Optical Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Meng Cheng", + "profile_link": "https://physics.yale.edu/people/meng-cheng", + "title": "Associate Professor", + "office": "SPL 54B", + "email": "m.cheng@yale.edu", + "phones": [], + "website": "https://meng-cheng.github.io/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-957-1472564395.jpg?itok=Vv0VYfUR", + "field_of_study": "Condensed Matter PhysicsTheoristQuantum criticality, Fractonic phases, Symmetric topological phases", + "profile_bio": null, + "website_text": null + }, + { + "name": "Yangyang Cheng", + "profile_link": "https://physics.yale.edu/people/yangyang-cheng", + "title": "Research Scholar", + "office": "Law School", + "email": "yangyang.cheng@yale.edu", + "phones": [], + "website": "https://law.yale.edu/yangyang-cheng", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3963-1638376812.jpg?itok=HIxaUpUl", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Li-Yuan Chiang", + "profile_link": "https://physics.yale.edu/people/li-yuan-chiang", + "title": "Graduate School Student", + "office": "SPL 76/SPL 58", + "email": "li-yuan.chiang@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4772-1693936184.png?itok=cGo_siMl", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Harper Cho", + "profile_link": "https://physics.yale.edu/people/harper-cho", + "title": "Graduate School Student", + "office": "harper.cho@yale.edu", + "email": "harper.cho@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3861-1733943918.png?itok=WzYzL2S5", + "field_of_study": "Biological Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "James Chow", + "profile_link": "https://physics.yale.edu/people/james-chow", + "title": "Graduate School Student", + "office": "SPL 28", + "email": "james.chow@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3191-1535124220.jpg?itok=AScptOUV", + "field_of_study": "Biological Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Damon Clark", + "profile_link": "https://physics.yale.edu/people/damon-clark", + "title": "Associate Professor of Molecular, Cellular and Developmental Biology and of Physics and of Neuroscience", + "office": "YSB C148", + "email": "damon.clark@yale.edu", + "phones": [ + "+1 (203) 432-0750" + ], + "website": "http://clarklab.commons.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-615-1759858057.jpg?itok=mpCfJEls", + "field_of_study": "BiophysicsExperimentalistHow networks of neurons perform computations", + "profile_bio": null, + "website_text": "We are interested in how networks of neurons perform computations. In order to dissect a neural computation, one must understand the task being performed, control the network’s inputs, and manipulate the system’s component parts. The fruit fly’s visual-motor transformations serve as an ideal model in which we can follow neural processing as the brain uses visual stimuli to guide behaviors. In order to uncover principles and mechanisms of visual processing, we create novel stimuli, measure fly behavior, monitor neural activity, and employ genetics to manipulate circuit function. In particular, we want to understand how animals extract information from the complex spatiotemporal visual patterns in the natural world, and how they make decisions based on that information. We want to understand and model how the system computes at an algorithmic level, and also to use the battery of genetic tools in the fruit fly to discover the neural and biophysical mechanisms that implement those algorithms. By comparing fly algorithms and mechanisms to vertebrate ones, we look for evolutionary constraints and diversity in solutions to basic computational tasks. If you are an undergraduate student, graduate student, or prospective postdoc with a background in neuroscience, biophysics, engineering, or physics, and you are interested in joining our team, please contact Damon Clark ." + }, + { + "name": "Colin Coane", + "profile_link": "https://physics.yale.edu/people/colin-coane", + "title": "Graduate School Student", + "office": "SPL 76/SPL 58", + "email": "colin.coane@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4773-1693936320.png?itok=u1oF9F_g", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Morgan Cole", + "profile_link": "https://physics.yale.edu/people/morgan-cole", + "title": "Graduate School Student", + "office": "morgan.cole@yale.edu", + "email": "morgan.cole@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4774-1693936435.png?itok=JPKTGNrK", + "field_of_study": "Astrophysics & Cosmology; Radio Astronomy; InstrumentationExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Cindy Conforte", + "profile_link": "https://physics.yale.edu/people/cindy-conforte", + "title": "Financial Assistant", + "office": "SPL 36A", + "email": "cynthia.conforte@yale.edu", + "phones": [ + "+1 (203) 432-3822" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-736-1439576747.jpg?itok=f-_ofjH0", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Paolo Coppi", + "profile_link": "https://physics.yale.edu/people/paolo-coppi", + "title": "Professor of Astronomy", + "office": "KT 453", + "email": "paolo.coppi@yale.edu", + "phones": [ + "203-432-3014" + ], + "website": "http://www.astro.yale.edu/coppi/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-106-1759858094.png?itok=BSFJdr4s", + "field_of_study": "Astrophysics & CosmologyExperimentalistHigh-Energy Plasma/Radiation Processes, Cosmological VHE Particle Propagation, Blazars and VHE Astronomy, Black Hole/Neutron Star Binaries, Early Star and Structure Formation, Gas-Mediated Black Hole Mergers, QUEST Large Area Driftscan Survey, Yale=Catan Deep X-Ray/Optical/NIR Survey", + "profile_bio": null, + "website_text": null + }, + { + "name": "Evan Craft", + "profile_link": "https://physics.yale.edu/people/evan-craft", + "title": "Graduate School Student", + "office": "SPL 52", + "email": "evan.craft@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3862-1681492121.jpg?itok=dWtYzBvD", + "field_of_study": "Particle PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Bárbara Cruvinel Santiago", + "profile_link": "https://physics.yale.edu/people/b-rbara-cruvinel-santiago", + "title": "Residential College Dean, Berkeley College and Lecturer in Physics", + "office": "Berkeley College", + "email": "barbara.santiago@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-638-1728920119.jpg?itok=R9Mm9Iy6", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Allison Culbert", + "profile_link": "https://physics.yale.edu/people/allison-culbert", + "title": "Graduate School Student", + "office": "allison.culbert@yale.edu", + "email": "allison.culbert@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3863-1652733635.jpg?itok=l4yOhsC0", + "field_of_study": "Biological PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Halona Dantes", + "profile_link": "https://physics.yale.edu/people/halona-dantes", + "title": "Graduate School Student", + "office": "halona.dantes@yale.edu", + "email": "halona.dantes@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4775-1693936567.png?itok=75udt3FF", + "field_of_study": "BiophysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Lucas Darroch", + "profile_link": "https://physics.yale.edu/people/lucas-darroch", + "title": "Postgraduate Associate pending degree", + "office": "lucas.darroch@yale.edu", + "email": "lucas.darroch@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5299-1753980897.jpg?itok=IS60VHO9", + "field_of_study": "Neutrinos & Fundamental Symmetries Instrumentation; Levitated OptomechanicsSIMPLE, nEXO", + "profile_bio": null, + "website_text": null + }, + { + "name": "Pepijn de Maat", + "profile_link": "https://physics.yale.edu/people/pepijn-de-maat", + "title": "Graduate School Student", + "office": "pepijn.demaat@yale.edu", + "email": "pepijn.demaat@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4165-1656426443.jpg?itok=ll7-o_3q", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Pratiti Deb", + "profile_link": "https://physics.yale.edu/people/pratiti-deb", + "title": "Postdoctoral Associate", + "office": "YSB C182", + "email": "pratiti.deb@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5308-1738180836.jpg?itok=i0z4w_OS", + "field_of_study": "Atomic, Molecular, and Optical PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Dallas DeMartini", + "profile_link": "https://physics.yale.edu/people/dallas-demartini", + "title": "Postdoctoral Associate", + "office": "SPL 66L", + "email": "dd996@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4260-1663337746.jpg?itok=jadGvY0B", + "field_of_study": "Nuclear PhysicsTheorist", + "profile_bio": "My research interests broadly cover theoretical aspects of nonperturbative nuclear physics. For my Ph.D. research, I studied potential signatures of the hypothetical QCD critical point in heavy-ion collisions and constructed statistical models of topological objects in QCD as a way to explain the confinement and chiral symmetry breaking. At Yale, I am shifting to work on nuclear structure physics. I am using modern numerical techniques to study statistical properties of heavy nuclei at finite temperatures.", + "website_text": null + }, + { + "name": "Sarah Demers", + "profile_link": "https://physics.yale.edu/people/sarah-demers", + "title": "Professor of Physics / Department Chair", + "office": "SPL 34 / KT 417", + "email": "sarah.demers@yale.edu", + "phones": [ + "203-432-3720 / 203-436-8501" + ], + "website": "http://demerslab.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-97-1707501963.jpg?itok=HgAXMKVI", + "field_of_study": "Particle PhysicsExperimentalistATLAS, MU2E", + "profile_bio": null, + "website_text": "Our group focuses on using tau leptons to probe for and characterize physics beyond the standard model at the ATLAS Experiment at CERN’s Large Hadron Collider. We are also involved in hunting for signs of new physics at the Mu2e Experiment at Fermilab. Current projects include measuring tau polarization at  ATLAS, the trigger of the Mu2e Experiment, and tau reconstruction at Muon Collider detectors." + }, + { + "name": "Aprameyan Desikan", + "profile_link": "https://physics.yale.edu/people/aprameyan-desikan", + "title": "Graduate School Student", + "office": "aprameyan.desikan@yale.edu", + "email": "aprameyan.desikan@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5458-1752612876.jpg?itok=PIiXDUPT", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Satish Dhawan", + "profile_link": "https://physics.yale.edu/people/satish-dhawan", + "title": "Senior Research Scientist (Retired) in Physics", + "office": "KT 407 / WL 205", + "email": "satish.dhawan@yale.edu", + "phones": [ + "203-432-3377" + ], + "website": "http://shaktipower.sites.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-99-1684414463.jpg?itok=d0h2TMV2", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": "Satish Dhawan - Power Electronics Welcome to Satish Dhawan’s Power Electronics website.  Satish is a Senior Research Scientist in the Department of Physics at Yale University. You can use the menu bar on the top to navigate the website. Publications has some recent papers and conference slides and posters. Seminars gives details of recent and upcoming technical seminars. Introduction Power electronics have become a focus of intense R&D in industry. Primary drivers of this R&D are the need for efficient delivery for smart phones, set top boxes, hand held gadgets, blade computers, Data Centers, etc. The industrial approach has featured the distribution of voltages higher than are required by the electronics. The voltage is stepped down at the point-of-load (POL) to provide the low voltages and high currents required by the electronics. The devices that perform these conversions, called DC-DC converters, use either magnetics in the form of inductors or transformers, or capacitors. Efficiency favors magnetic converters in high ratios of input to output voltage and thus magnetic converters are the focus of our research. The simplest magnetic topology for the DC-DC converter, called a Buck Regulator, is schematically illustrated in the figure and a PCB implementation. Synchronous Buck Converter illustrating the components. The switching frequency is 1 MHz and the input/output voltage ratio is 9. Buck Converter with Embedded Coreless Inductor.  Size = 2.4 x 7 cms High Energy Physics can benefit from the massive R&D investment of the industrial community. Many of the requirements are the same, namely small size, high efficiency, and high frequency. Two main primary differences are the need for radiation resistance in High Energy Physics, and often the need to operate in high magnetic fields (>1 Tesla) as well. The latter requirement precludes the use of ferrites and drives the need for high frequency operation. Fortunately, the industrial requirements for smaller sizes are driving the need for higher frequency operation as well. Over the last several years we have been identifying market trends that are leading to promising technologies that may serve the High Energy Physics Community. My collaborators and I have been radiation testing selected devices and switches that may result in fully commercial or semi-custom solutions for the various High Energy Physics Applications. This website presents the status of the R&D to date, as well as information on promising technologies. In 2007 to our surprise, the first commercial converter that we exposed withstood 100 Mrads of gamma radiation (beginners’ luck). It was fabricated with 5nm thin gate oxide. It is possible to design LDMOS Switches with this thin oxide and be able to operate at > 12 volts. Gallium Nitride material has been in development for decades. in 1975 a HEMT (high electron mobility transistor) structure was described and in 1994 an unusually high electron mobility was measured. In 2004 Eudyna introduced RF power amplifiers for cellular base station applications, replacing silicon devices. Recently EPC corp. started to sell GaN on silicon for power converters. These can operate at high input/output ratios, thus reducing power supply input currents. Why GaN over Silicon? Very high frequency operation, low on resistance, x10 higher breakdown voltage, and GaN devices can be fabricated Using existing silicon infrastructure." + }, + { + "name": "Josh Donoghue", + "profile_link": "https://physics.yale.edu/people/josh-donoghue", + "title": "Senior Administrative Assistant", + "office": "KT 459", + "email": "josh.donoghue@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5497-1756402330.jpg?itok=i5nNR344", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Isaque Dutra", + "profile_link": "https://physics.yale.edu/people/isaque-dutra", + "title": "Graduate School Student", + "office": "KT 403", + "email": "isaque.dutra@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3516-1725810086.jpg?itok=oSSru4SH", + "field_of_study": "Astrophysics/CosmologyTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Thierry Emonet", + "profile_link": "https://physics.yale.edu/people/thierry-emonet", + "title": "Lewis B. Cullman Professor of Molecular, Cellular and Developmental Biology and Professor of Physics", + "office": "YSB C169", + "email": "thierry.emonet@yale.edu", + "phones": [ + "+1 (203) 432-3516" + ], + "website": "http://emonet.biology.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-109-1759859363.png?itok=CMEi62H5", + "field_of_study": "BiophysicsTheorist & ExperimentalistWe are currently running experiments and theory studying how cells and flies sense chemicals and use that information to make decisions during goal oriented tasks such as chemical navigation. We study these processes from molecules to animal behavior.", + "profile_bio": null, + "website_text": null + }, + { + "name": "Antonio Ereditato", + "profile_link": "https://physics.yale.edu/people/antonio-ereditato", + "title": "Visiting Professor", + "office": "Wright Lab", + "email": "antonio.ereditato@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3720-1614623013.jpg?itok=zgieIvnm", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Ryan Everly", + "profile_link": "https://physics.yale.edu/people/ryan-everly", + "title": "Graduate School Student", + "office": "ryan.everly@yale.edu", + "email": "ryan.everly@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4776-1693936696.png?itok=9YRIofVv", + "field_of_study": "Atomic, Molecular, and Optical PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Paula Farnsworth", + "profile_link": "https://physics.yale.edu/people/paula-farnsworth", + "title": "Senior Administrative Assistant", + "office": "WL-W 310", + "email": "paula.farnsworth@yale.edu", + "phones": [ + "203-432-6044" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-290-1733943977.png?itok=sTyKUmoZ", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Jesse Farr", + "profile_link": "https://physics.yale.edu/people/jesse-farr", + "title": "Graduate School Student", + "office": "KT 429", + "email": "jesse.farr@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4192-1657282617.jpg?itok=Hifv-MAy", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Joaquin Fernandez Odell", + "profile_link": "https://physics.yale.edu/people/joaquin-fernandez-odell", + "title": "Graduate School Student", + "office": "joaquin.fernandezodell@yale.edu", + "email": "joaquin.fernandezodell@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5459-1751372953.jpg?itok=Ck-T45JZ", + "field_of_study": "", + "profile_bio": "I am interested in emergent behavior in many body quantum systems, and its application to quantum information.", + "website_text": null + }, + { + "name": "Devon Finlay", + "profile_link": "https://physics.yale.edu/people/devon-finlay", + "title": "Graduate School Student", + "office": "devon.finlay@yale.edu", + "email": "devon.finlay@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4154-1654616707.jpg?itok=JJEx3DbG", + "field_of_study": "Biological Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Bonnie Fleming", + "profile_link": "https://physics.yale.edu/people/bonnie-fleming", + "title": "Research Scientist", + "office": "Fermilab", + "email": "bonnie.fleming@yale.edu", + "phones": [ + "+1 (203) 432-3235" + ], + "website": "https://hep.yale.edu/people/bonnie-fleming", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4241-1662049702.jpg?itok=K10kQlin", + "field_of_study": "Particle PhysicsExperimentalistArgoNeuT, LArIAT, MicroBooNE, SBND, DUNE", + "profile_bio": "Our group, headed by Prof. Bonnie Fleming, studies neutrinos. We are largely an experimental group focusing on new physics in the neutrino sector. In the near term, we are working on the MicroBooNE and LArIAT experiments now running at Fermilab. We are also working on construction of the SBND detector to be assembled and installed as a near detector on the Booster Neutrino Beamline at Fermilab. In the longer term, we are collaborating on the DUNE long baseline experiment. Concurrently, we are developing the next generation of accelerator neutrino detectors for these programs – Liquid Argon Time Projection Chambers.", + "website_text": null + }, + { + "name": "Paul Fleury", + "profile_link": "https://physics.yale.edu/people/paul-fleury", + "title": "Frederick William Beinecke Professor Emeritus of Engineering and Applied Physics & Physics", + "office": "paul.fleury@yale.edu", + "email": "paul.fleury@yale.edu", + "phones": [ + "+1 (203) 432-4216" + ], + "website": "https://appliedphysics.yale.edu/paul-fleury", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3557-1590693610.jpg?itok=SqAcLSEQ", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Kirstin Franzman", + "profile_link": "https://physics.yale.edu/people/kirstin-franzman", + "title": "Senior Administrative Assistant, Chair’s office", + "office": "SPL 34", + "email": "kirstin.franzman@yale.edu", + "phones": [ + "203-432-3650" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4133-1712770836.jpg?itok=BHqGxUBD", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Yu Fu", + "profile_link": "https://physics.yale.edu/people/yu-fu", + "title": "Graduate School Student", + "office": "y.fu@yale.edu", + "email": "y.fu@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5101-1722263201.png?itok=HOrHBKLb", + "field_of_study": "BiophysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Shankar Ganesh", + "profile_link": "https://physics.yale.edu/people/shankar-ganesh", + "title": "Yale Postdoctoral Prize Fellow", + "office": "SPL 54", + "email": "shankar.ganesh@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5201-1726843181.jpg?itok=cej5YsNK", + "field_of_study": "Condensed Matter PhysicsTheorist", + "profile_bio": "My research interests are broadly based on strongly correlated electron systems, topological band theory, and quantum field theory. My recent work has focused on instanton-driven confinement transitions out of fractionalized phases like spin liquids, and the development of a “hyperbolic band theory” for a novel class of synthetic materials hosted on hyperbolic lattices.", + "website_text": null + }, + { + "name": "Arianna Garcia Caffaro", + "profile_link": "https://physics.yale.edu/people/arianna-garcia-caffaro", + "title": "Graduate School Student", + "office": "KT 437", + "email": "arianna.garciacaffaro@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3517-1591041002.png?itok=kOkW8ANY", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Prakhar Garg", + "profile_link": "https://physics.yale.edu/people/prakhar-garg", + "title": "Research Scientist", + "office": "WLW", + "email": "prakhar.garg@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4662-1689016358.jpg?itok=t8XZXlRj", + "field_of_study": "Nuclear Physics, Particle DetectorsExperimentalist", + "profile_bio": "My current research interest is in Gaseous detectors and Photon detectors. I am involved in several R&D projects with a focus on detectors for the Electron Ion Collider (EIC) soon to be under construction at Brookhaven National Laboratory.", + "website_text": null + }, + { + "name": "John Garmon", + "profile_link": "https://physics.yale.edu/people/john-garmon", + "title": "Graduate School Student", + "office": "BCT", + "email": "john.garmon@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3518-1590606854.jpg?itok=DZQNSfbd", + "field_of_study": "Quantum Information Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Marla Geha", + "profile_link": "https://physics.yale.edu/people/marla-geha", + "title": "Professor of Astronomy and of Physics", + "office": "STN 215", + "email": "marla.geha@yale.edu", + "phones": [ + "+1 (203) 432-5796" + ], + "website": "https://geha-group.github.io/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-112-1592398083.jpg?itok=Y2YnR09b", + "field_of_study": "Astrophysics & CosmologyExperimentalistDwarf Galaxies and Near Field Cosmology", + "profile_bio": "Dwarf galaxies are the dominate type of galaxy in the Universe by number.  Dwarf galaxies are less luminous and more dark-matter dominated as compared to our Milky Way, providing significant constraints on galaxy formation processes, cosmology and the nature of dark matter.  We are focused on understanding dwarf galaxies around our Milky Way, Local Group and nearby Universe.", + "website_text": null + }, + { + "name": "Milan Gemaljevic", + "profile_link": "https://physics.yale.edu/people/milan-gemaljevic", + "title": "Graduate School Student", + "office": "milan.gemaljevic@yale.edu", + "email": "milan.gemaljevic@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5113-1723838885.png?itok=MmDlKCve", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Mehdi Ghiassi-Nejad", + "profile_link": "https://physics.yale.edu/people/mehdi-ghiassi-nejad", + "title": "Research Associate", + "office": "SPL 72A", + "email": "mehdi.ghiassi-nejad@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-2401-1512419989.jpg?itok=YaNyTweT", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Steven Girvin", + "profile_link": "https://physics.yale.edu/people/steven-girvin", + "title": "Sterling Professor of Physics", + "office": "YQI 403", + "email": "steven.girvin@yale.edu", + "phones": [ + "+1 (203) 432-5082" + ], + "website": "http://girvin.sites.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-16-1737562481.jpg?itok=GTs6Sw_w", + "field_of_study": "Condensed Matter PhysicsTheorist", + "profile_bio": null, + "website_text": "Cambridge University Press, 2019 Sterling Professor of Physics & Professor of Applied Physics, Yale University Member and Founding Director, Co-Design Center for Quantum Advantage, Brookhaven National Laboratory https://www.bnl.gov/quantumcenter/ Education: BS, Bates College; MS U. Maine; Ph.D., Princeton University Field of Study: Quantum Information Science, Quantum Optics, and Theoretical Condensed Matter Physics After graduating in a high school class of 5 students in the small village of Brant Lake, New York and completing his undergraduate degree in physics from Bates College, Dr. Girvin earned his Ph.D. in theoretical physics from Princeton University in 1977. Dr. Girvin joined the Yale faculty in 2001, where he is Sterling Professor of Physics and Professor of Applied Physics. From 2007 to 2017 he served as Yale’s Deputy Provost for Research, overseeing strategic planning for research across Yale. From 2019 to 2021, he served as founding director of the Co-Design Center for Quantum Advantage, one of five national quantum information science research centers funded by the Department of Energy. Along with his experimenter colleagues Michel Devoret and Robert Schoelkopf, Professor Girvin co-developed ‘circuit QED,’ the industrial standard architecture for construction of quantum computers based on superconducting microwave circuits. Dr. Girvin is a Foreign Member of the Royal Swedish Academy of Sciences and Member of the US National Academy of Sciences. In 2007, he and his collaborators, Allan H. MacDonald and James P. Eisenstein were awarded the Oliver E. Buckley Prize of the American Physical Society for their work on the fractional quantum Hall effect. In 2017, Professor Girvin received an honorary degree from Chalmers University of Technology in recognition of his work co-developing circuit QED. In 2019, he and coauthor Kun Yang published the textbook Modern Condensed Matter Physics with Cambridge University Press." + }, + { + "name": "Brian Gitahi", + "profile_link": "https://physics.yale.edu/people/brian-gitahi", + "title": "Graduate School Student", + "office": "brian.gitahi@yale.edu", + "email": "brian.gitahi@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5102-1722263252.png?itok=mKz_IwGb", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Larry Gladney", + "profile_link": "https://physics.yale.edu/people/larry-gladney", + "title": "Phyllis Wallace Dean of Diversity and Faculty Development in the Faculty of Arts and Sciences, Professor of Physics", + "office": "Warner House 301", + "email": "larry.gladney@yale.edu", + "phones": [ + "203-432-6814" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3274-1712257566.jpg?itok=Dv1jdSFy", + "field_of_study": "Astrophysics & Cosmology; Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Leonid Glazman", + "profile_link": "https://physics.yale.edu/people/leonid-glazman", + "title": "Donner Professor of Physics", + "office": "SPL 55A", + "email": "leonid.glazman@yale.edu", + "phones": [ + "+1 (203) 432-6920" + ], + "website": "http://campuspress.yale.edu/leonidglazman/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-113-1754938821.jpg?itok=4gzh7MGi", + "field_of_study": "Condensed Matter PhysicsTheoristPhysics of mesoscopic solids: nonlinear Luttinger liquid, topological insulators, mesoscopic electron transport, edge states and collective excitations, quantum fluctuations of charge and spin.Superconductivity: qubits, mesoscopic superconductors, properties of layered superconductors (including high-Tc materials)Cold atoms: dynamics of low-dimensional quantum fluids", + "profile_bio": "Professor Glazman is interested in dynamic properties of quantum low-dimensional interacting systems. These include a diverse set of objects, such as low-dimensional quantum fluids, topological materials, and various condensed matter implementations of qubits. He actively collaborates with the Yale experimental groups in the field of quantum information, and with quantum materials groups outside Yale University.", + "website_text": null + }, + { + "name": "Naomi Gluck", + "profile_link": "https://physics.yale.edu/people/naomi-gluck", + "title": "Graduate School Student", + "office": "KT 463", + "email": "naomi.gluck@yale.edu", + "phones": [], + "website": "https://ngluck.github.io/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3864-1746118124.jpg?itok=fnxu39aa", + "field_of_study": "Astrophysics/Cosmology", + "profile_bio": null, + "website_text": null + }, + { + "name": "Walter Goldberger", + "profile_link": "https://physics.yale.edu/people/walter-goldberger", + "title": "Professor of Physics", + "office": "SPL 53A", + "email": "walter.goldberger@yale.edu", + "phones": [ + "+1 (203) 432-6902" + ], + "website": "http://het.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-114-1737562043.jpg?itok=RR_Img0M", + "field_of_study": "Particle PhysicsTheorist", + "profile_bio": null, + "website_text": "Welcome Our group works on diverse topics in theoretical high energy physics, including physics beyond the Standard Model, field theory, quantum chromodynamics, conformal bootstrap, and early universe physics." + }, + { + "name": "Mark Gonzalez", + "profile_link": "https://physics.yale.edu/people/mark-gonzalez", + "title": "Graduate School Student", + "office": "SPL 45A", + "email": "mark.gonzalez@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3520-1590606812.jpg?itok=KRMqSEmN", + "field_of_study": "Particle PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Gautham Gopinath", + "profile_link": "https://physics.yale.edu/people/gautham-gopinath", + "title": "Graduate School Student", + "office": "gautham.gopinath@yale.edu", + "email": "gautham.gopinath@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4147-1654086998.jpg?itok=zKAzNxaF", + "field_of_study": "BiophysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Eleanor Graham", + "profile_link": "https://physics.yale.edu/people/eleanor-graham", + "title": "Graduate School Student", + "office": "WLC 254A", + "email": "eleanor.graham@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3521-1630416224.jpg?itok=7CVnXa3G", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Jay Graves", + "profile_link": "https://physics.yale.edu/people/jay-graves", + "title": "Graduate School Student", + "office": "jay.graves@yale.edu", + "email": "jay.graves@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5119-1723746721.png?itok=0ipomslP", + "field_of_study": "Quantum Information Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Aaron Greenberg", + "profile_link": "https://physics.yale.edu/people/aaron-greenberg", + "title": "Graduate School Student", + "office": "a.greenberg@yale.edu", + "email": "a.greenberg@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4143-1653672435.jpg?itok=RhaKttYu", + "field_of_study": "Condensed Matter PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Chitres Guria", + "profile_link": "https://physics.yale.edu/people/chitres-guria", + "title": "Graduate School Student", + "office": "WLW 327", + "email": "chitres.guria@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3336-1579015152.jpg?itok=AJZlLjEA", + "field_of_study": "Atomic & Optical Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Tyler Hadsell", + "profile_link": "https://physics.yale.edu/people/tyler-hadsell", + "title": "Graduate School Student", + "office": "tyler.hadsell@yale.edu", + "email": "tyler.hadsell@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5460-1751373109.jpg?itok=oOiZ6GHX", + "field_of_study": "", + "profile_bio": "I am interested in studies and applications of topological materials, most notably topologically protected quantum computing. I am also very interested in high energy physics and standard model expansions.", + "website_text": null + }, + { + "name": "Mark Haeckel", + "profile_link": "https://physics.yale.edu/people/mark-haeckel", + "title": "R&D Technician 3 - Mechanical Technician", + "office": "WLW", + "email": "mark.haeckel@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4753-1733944033.png?itok=idGDJhID", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Ryan Hamilton", + "profile_link": "https://physics.yale.edu/people/ryan-hamilton", + "title": "Graduate School Student", + "office": "WLW-301", + "email": "ryan.hamilton@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4777-1693936862.png?itok=scrs73ac", + "field_of_study": "Nuclear PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Avery Hanna", + "profile_link": "https://physics.yale.edu/people/avery-hanna", + "title": "Graduate School Student", + "office": "avery.hanna@yale.edu", + "email": "avery.hanna@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5461-1751561260.png?itok=W6vI4LFp", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": "I'm interested in experimental particle physics — particularly how machine learning and quantum technology can advance our knowledge in this field.", + "website_text": null + }, + { + "name": "Caitlin Hansen", + "profile_link": "https://physics.yale.edu/people/caitlin-hansen", + "title": "Lecturer; Chair, Outreach Committee", + "office": "SPL 40", + "email": "caitlin.k.hansen@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3931-1634316952.jpg?itok=7VUHzi-L", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Yinchen Hao", + "profile_link": "https://physics.yale.edu/people/yinchen-hao", + "title": "Applied Physics Graduate School Student", + "office": "YSB C182", + "email": "yinchen.hao@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4904-1704286651.jpg?itok=H_Gh3Tn-", + "field_of_study": "AMOExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Clarke Hardy", + "profile_link": "https://physics.yale.edu/people/clarke-hardy", + "title": "Postdoctoral Associate", + "office": "WL 230A", + "email": "clarke.hardy@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5518-1759324764.png?itok=8YNoisT3", + "field_of_study": "Neutrino physics & optomechanicsExperimentalist", + "profile_bio": "My research focuses on experimental tests of fundamental physics using both large-scale detectors and precision small-scale instruments. I am particularly interested in open questions in neutrino physics, such as the origin of neutrino mass and the possible existence of sterile neutrinos.", + "website_text": null + }, + { + "name": "Jack Harris", + "profile_link": "https://physics.yale.edu/people/jack-harris", + "title": "Professor of Physics", + "office": "SPL 49, WLW 327", + "email": "jack.harris@yale.edu", + "phones": [ + "+1 (203) 432-3826" + ], + "website": "http://www.yale.edu/harrislab/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-116-1737561812.jpg?itok=2w5xihaE", + "field_of_study": "Atomic, Molecular, and Optical PhysicsExperimentalistOptomechanics: Radiation Pressure - Radiation pressure in the quantum engine, Optical control of microstructures, Mechanical control of nonclassical light and Persistent Current - Microcantilevers and probes of closed mesoscopic systems, In-situ electron thermometry, Persistent currents in normal-metal rings", + "profile_bio": "Professor Harris studies the quantum aspects of motion in macroscopic objects that combine mechanical, optical, and superfluid components. His group’s experiments use ultrasensitive force detectors to measure quantum fluctuations of objects that are visible to the naked eye. These experiments are also used to study novel topological features in the dynamics of coupled oscillators.", + "website_text": null + }, + { + "name": "John Harris", + "profile_link": "https://physics.yale.edu/people/john-harris", + "title": "D. Allan Bromley Professor Emeritus", + "office": "WL-W 311", + "email": "john.harris@yale.edu", + "phones": [ + "203-432-6106" + ], + "website": "http://star.physics.yale.edu/johnharris/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-117-1737561882.jpg?itok=H9-3EsZS", + "field_of_study": "Nuclear PhysicsExperimentalist", + "profile_bio": "The research interests of Professor John Harris are focused on understanding high energy density Quantum Chromodynamics (QCD) created in relativistic collisions of heavy nuclei. QCD calculations on a lattice predict that a transition from normal nuclear or hadronic matter to a deconfined phase of matter consisting of strongly interacting quarks and gluons, known as the Quark-Gluon Plasma (QGP), will occur at extremely high energy densities above approximately 2 GeV/fm 3 . This corresponds to a temperature of 2 x 10 12 Kelvin. Such energy densities are predicted to have existed a few microseconds after the Big Bang, are created in collisions of heavy nuclei at ultrarelativistic energies and may exist in the cores of neutron stars. Formation and discovery of the QGP is the primary purpose of ultrarelativistic nucleus-nucleus experiments at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory on Long Island in New York and at the Large Hadron Collider at CERN in Geneva, Switzerland.\nJohn Harris was involved in the original proposal to initiate a nucleus-nucleus experimental program at CERN to search for a possible QGP phase transition, and has been an active member in the planning, conceptual design, construction, data acquisition and physics of ultrarelativistic nucleus-nucleus experiments NA35 and NA49 at CERN, and the STAR (Solenoidal Tracker at RHIC) experiment at Brookhaven. He was the founding spokesperson for STAR from 1991 until 2002. He is currently involved in the ALICE experiment at the LHC at CERN and has served as the National Coordinator for the ALICE-USA Collaboration, Chair and Deputy Chair of the ALICE Collaboration Board and on other boards in ALICE (e.g. Physics Board). Research activities focus on the use of hard scattering processes to identify the properties of the QGP utilizing heavy ions and the design of a comprehensive experiment for the forthcoming Electron Ion Collider .", + "website_text": null + }, + { + "name": "Laura Havener", + "profile_link": "https://physics.yale.edu/people/laura-havener", + "title": "Assistant Professor", + "office": "Wright Lab-West 303", + "email": "laura.havener@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3270-1684760993.jpg?itok=D6Is41VI", + "field_of_study": "Nuclear PhysicsExperimentalistALICE, ePIC, and STAR", + "profile_bio": "Professor Havener’s research focuses on experimentally studying quantum chromodynamics (QCD) using high-energy particle colliders. Specifically, she is interested in understanding the properties and dynamics of the deconfined state of QCD matter called the quark-gluon plasma (QGP), produced in heavy-ion collisions. As a member of the ALICE collaboration at the Large Hadron Collider (LHC), she studies high-energy particles known as jets and how they interact with the QGP. She specializes in using Jet Substructure techniques to explore the complex structure of jets, revealing the intricate nature of the QGP.", + "website_text": null + }, + { + "name": "Baichuan He", + "profile_link": "https://physics.yale.edu/people/baichuan-he", + "title": "Graduate School Student", + "office": "baichuan.he@yale.edu", + "email": "baichuan.he@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5103-1733944074.png?itok=4p4zoGJG", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Yu He", + "profile_link": "https://physics.yale.edu/people/yu-he", + "title": "Assistant Professor of Applied Physics and of Physics", + "office": "BCT 327", + "email": "yu.he@yale.edu", + "phones": [ + "+1 (650) 3916289" + ], + "website": "https://sites.google.com/yale.edu/becton326/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3942-1759859387.png?itok=j0FEEYlD", + "field_of_study": "Condensed Matter PhysicsExperimentalistMetal to insulator transitions, Superconductivity, 2D Magnetism, Solid State Quantum Simulation", + "profile_bio": "Yu He joined Yale Applied Physics as an assistant professor in the fall of 2020. His research mainly utilizes light-matter interaction to investigate correlated electronic systems and other functional quantum materials. He focuses on dissecting novel materials’ microscopic degrees of freedom - electronic, lattice and spin - via angle-resolved photoemission spectroscopy and x-ray scattering techniques. Complementary techniques such as electric transport, surface decoration and crystal synthesis are employed to characterize and manipulate material properties. Yu obtained his B.S. in Physics from University of Science and Technology of China (USTC), M.S. in Electrical Engineering and Ph.D. in Applied Physics from Stanford University. Prior to arriving at Yale, he worked as a Miller Research Fellow at the University of California at Berkeley.", + "website_text": null + }, + { + "name": "Karsten Heeger", + "profile_link": "https://physics.yale.edu/people/karsten-heeger", + "title": "Eugene Higgins Professor of Physics / Director Wright Laboratory", + "office": "WL 214", + "email": "karsten.heeger@yale.edu", + "phones": [ + "203-432-3378" + ], + "website": "http://heegerlab.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-334-1666370889.jpg?itok=tBSssYKL", + "field_of_study": "Nuclear Physics; Particle PhysicsExperimentalistPROSPECT - Precision Oscillation and Spectrum Experiment (PROSPECT),PI and Co-spokesperson;CUPID-CUORE Upgrade with Particle IDentification,Co-spokesperson;CUORE-Cryogenic Underground Observatory for Rare Events,collaboration member;Project 8-An experiment to measure the direct neutrino mass,collaboration member; DUNE - Deep Underground Neutrino Experiment,collaboration member", + "profile_bio": "Professor Heeger’s research focuses on the study of neutrino oscillations and neutrino mass. He was involved in the resolution of the solar neutrino problem with the Sudbury Neutrino Observatory (SNO), the first observation of reactor antineutrino oscillation with KamLAND, and the first measurement of the neutrino mixing angle q 13 with Daya Bay. Heeger is PI and co-spokesperson of PROSPECT, a precision measurement of reactor antineutrinos and search for sterile neutrinos at very short baselines. He is studying the nature of neutrinos with the CUORE double beta decay experiment and performing R&D with Project 8 towards a novel experiment to measure neutrino mass. In 2021 he was elected co-spokesperson of CUPID, the CUORE Upgrade with Particle Identification.", + "website_text": null + }, + { + "name": "Victor Henrich", + "profile_link": "https://physics.yale.edu/people/victor-henrich", + "title": "Eugene Higgins Professor Emeritus of Applied Science, Applied Physics & Physics", + "office": "BCT 327", + "email": "victor.henrich@yale.edu", + "phones": [ + "203-432-4399" + ], + "website": "http://appliedphysics.yale.edu/victor-e-henrich", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-118-1357315697.jpg?itok=dLCcOFaj", + "field_of_study": "Condensed Matter PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Erica Herrera Huaman", + "profile_link": "https://physics.yale.edu/people/erica-herrera-huaman", + "title": "Graduate School Student", + "office": "erica.herrerahuaman@yale.edu", + "email": "erica.herrerahuaman@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5462-1753217009.png?itok=wBV5SYWq", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Eduardo Higino da Silva Neto", + "profile_link": "https://physics.yale.edu/people/eduardo-higino-da-silva-neto", + "title": "Assistant Professor of Physics", + "office": "ESI-II A151/ SPL68E", + "email": "eduardo.dasilvaneto@yale.edu", + "phones": [ + "530 554 2767" + ], + "website": "http://campuspress.yale.edu/dasilvaneto", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3405-1574087592.jpg?itok=pAgIJKMg", + "field_of_study": "Condensed Matter PhysicsExperimentalist", + "profile_bio": "Eduardo H. da Silva Neto’s research is focused on the use of advanced spectroscopic techniques targeting the discovery and investigation of emergent electronic quantum states of matter. His group’s interests follow two intersecting directions: the study of intertwined orders in strongly correlated quantum materials and the investigation of emergent topological states in solids. For these studies we employ low-temperature and high magnetic field STM/S to visualize the quantum wave functions of electrons at the atomic scale, complemented by light-matter interaction experiments such as RXS and ARPES at synchrotron facilities.", + "website_text": null + }, + { + "name": "Jonathon Howard", + "profile_link": "https://physics.yale.edu/people/jonathon-howard", + "title": "Eugene Higgins Professor of Molecular Biophysics & Biochemistry", + "office": "Bass 334", + "email": "jonathon.howard@yale.edu", + "phones": [ + "203-432-7245" + ], + "website": "https://medicine.yale.edu/profile/joe_howard/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-492-1638814850.jpg?itok=lXb2porY", + "field_of_study": "BiophysicsExperimentalistMechanics of Motor Proteins and the Cytoskeleton", + "profile_bio": "Mechanics of Motor Proteins and the Cytoskeleton The Howard lab is fascinated by the question of how small molecules like proteins, lipids and nucleotides self-assemble into cells and tissues that are thousands to millions of times larger than molecular dimensions. How do the molecules know where they should be, and whether the structures that they have made are the right size, shape and location? By combining highly sensitive techniques to visualize and manipulate individual biological molecules with theory and modeling, the Howard lab is trying to understand the interaction rules that allow molecules to work together to form highly organized yet dynamic cellular structures. The Howard lab is approaching these questions in the context of the microtubule cytoskeleton. They are interested in the molecular properties of motor proteins and microtubule assembly regulators, especially how they operate as molecular machines to drive motion and regulate the growth and shrinkage of microtubules. In addition to biochemical and single-molecule approaches, they also study a number of cellular systems including the morphogenesis of neuronal dendrites, mitosis, mechanoreceptors, and cilia & flagella and. Specialized Terms: Microtubules, Motor proteins, MAPs, Cytoskeleton, Microtubule dynamics, Cell motility, Mitosis, the Axoneme, Optical tweezers, Single-molecule biophysics Click here for further information", + "website_text": null + }, + { + "name": "Songtao Huang", + "profile_link": "https://physics.yale.edu/people/songtao-huang", + "title": "Graduate School Student", + "office": "SPL 11", + "email": "songtao.huang@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3523-1633441749.jpg?itok=qTsg9jml", + "field_of_study": "Atomic & Optical Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Theophilus Human", + "profile_link": "https://physics.yale.edu/people/theophilus-human", + "title": "Graduate School Student", + "office": "WLW 327", + "email": "theophilus.human@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4141-1653671220.jpg?itok=ip4W92tg", + "field_of_study": "AMOExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Tom Hurteau", + "profile_link": "https://physics.yale.edu/people/tom-hurteau", + "title": "Research & Development Technician", + "office": "tom.hurteau@yale.edu", + "email": "tom.hurteau@yale.edu", + "phones": [ + "+1 (203) 605-6787" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3380-1733944148.png?itok=tis6yPvQ", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Forrest Hutchison", + "profile_link": "https://physics.yale.edu/people/forrest-hutchison", + "title": "Graduate School Student", + "office": "forrest.hutchison@yale.edu", + "email": "forrest.hutchison@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5432-1752861885.png?itok=QPgvuq3Q", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Francesco Iachello", + "profile_link": "https://physics.yale.edu/people/francesco-iachello", + "title": "JW Gibbs Professor Emeritus and Research Professor of Physics", + "office": "SPL 65", + "email": "francesco.iachello@yale.edu", + "phones": [ + "203-432-6944 / 203-432-6916" + ], + "website": "https://campuspress.yale.edu/francescoiachello/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-119-1357315943.jpg?itok=FO4AGwrr", + "field_of_study": "Theoretical Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Sohrab Ismail-Beigi", + "profile_link": "https://physics.yale.edu/people/sohrab-ismail-beigi", + "title": "Strathcona Professor of Applied Physics; Chair of Applied Physics", + "office": "BCT 307", + "email": "sohrab.ismail-beigi@yale.edu", + "phones": [ + "+1 (203) 432-2107" + ], + "website": "http://volga.eng.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-120-1721138720.png?itok=FDXTAiQF", + "field_of_study": "Condensed Matter PhysicsTheoristWe study the physics of condensed matter systems, usually the solid state, using first principles or ab initio methods. We solve the quantum mechanical many-body problem of interacting electrons and ions to the best of our abilities, with the fewest approximations possible, and with no adjustable parameters or fitting. The cost is that the calculations must be done numerically and can be quite difficult to perform. The advantage is that the results are generally reliable and accurate, and hence can be compared with confidence to experimental findings to help understand, clarify, and even predict observed physical phenomena.", + "profile_bio": "Our group uses first principles computational methods to attack topical and fundamental questions in condensed matter theory and materials physics/chemistry. Present topics of interest include: Transition metal oxide interfaces and surfaces: electronic and atomic reconstructions, orbital control, novel electronic phases, design principles, electronic correlations, switchable properties, catalysis Semiconductor-oxide interfaces: growth strategies and resulting structures, electronic/chemical/mechanical properties, engineering interfaces for desired technological applications Electronic, mechanical, and structural properties of nanomaterials: nanotubes, nanowires, 2D systems, and clusters Slave-boson methods for complex oxides and approximate solution of extended Hubbard models Many-body Green’s function methods for describing exchange and correlation Software development for massively parallel GW calculations You can find more details of our research group regarding research activities, publications, group members, and recent news by visiting the Ismail-Beigi research group website .", + "website_text": "Graduate student and postdoctoral openings: (updated July 25, 2025) At the moment the group is nearing capacity: a ll postdoctoral and grduate student positions that were open have been filled until the fall  of 2025.  We will post a note here if there are openings; generally, this status changes on a 6-12 month time scale. Online Publication Views: Google Scholar ResearchGate Public software releases: 1. BoSS slave-boson code first released July 13 2018. 2. OpenAtom GW code first released September 3 2018. Our research group studies condensed matter systems, often in the solid state, using first principles or ab initio electronic structure methods. We are part of Yale Applied Physics at Yale University Yale Physics and the Condensed Matter Theory Group Yale Mechanical and Materials Science Department CRISP: a Yale’s materials research center We study the physics of condensed matter systems, usually the solid state, using first principles or ab initio methods. We solve the quantum mechanical many-body problem of interacting electrons and ions to the best of our abilities, with the fewest approximations possible, and with no adjustable parameters or fitting. The cost is that the calculations must be done numerically and can be quite difficult to perform. The advantage is that the results are generally reliable and accurate, and hence can be compared with confidence to experimental findings to help understand, clarify, and even predict observed physical phenomena. The reliability also implies that we can use ab initio modeling as an ideal virtual laboratory to study microscopic physical phenomena. By ideal we mean that the physical setup (atomic positions, boundary conditions, imposed fields, etc.) is specifiable and modifiable at will." + }, + { + "name": "Akshai Jayakumar Pillai", + "profile_link": "https://physics.yale.edu/people/akshai-jayakumar-pillai", + "title": "Applied Physics Graduate School Student", + "office": "WLW 237", + "email": "akshai.jayakumarpillai@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3842-1733944184.png?itok=AlFEYF82", + "field_of_study": "Atomic & Optical Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Michael Jewell", + "profile_link": "https://physics.yale.edu/people/michael-jewell", + "title": "Associate Research Scientist", + "office": "WLC 254C", + "email": "michael.jewell@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3550-1738172514.png?itok=4zFsDVjR", + "field_of_study": "Astrophysics & Cosmology, Quantum Science & SensingExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Yue Jiang", + "profile_link": "https://physics.yale.edu/people/yue-jiang", + "title": "Lab Associate", + "office": "YSB C188", + "email": "yue.jiang@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5312-1738181116.png?itok=G4JJB1Cq", + "field_of_study": "Condensed Matter PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Tyler Johnson", + "profile_link": "https://physics.yale.edu/people/tyler-johnson", + "title": "Postdoctoral Associate", + "office": "WLC 254C", + "email": "tyler.johnson.tj432@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5277-1733941873.png?itok=HnMkFWFg", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Lukas Kienesberger", + "profile_link": "https://physics.yale.edu/people/lukas-kienesberger", + "title": "Graduate School Student", + "office": "lukas.kienesberger@yale.edu", + "email": "lukas.kienesberger@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5104-1722263328.png?itok=5unYv-_p", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "HongJoon Kim", + "profile_link": "https://physics.yale.edu/people/hongjoon-kim", + "title": "Graduate School Student", + "office": "hongjoon.kim@yale.edu", + "email": "hongjoon.kim@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4199-1658494656.jpg?itok=EoU-rSDJ", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Daphne Klemme", + "profile_link": "https://physics.yale.edu/people/daphne-klemme", + "title": "Senior Administrative Assistant; Undergraduate Registrar", + "office": "SPL 36", + "email": "daphne.klemme@yale.edu", + "phones": [ + "203-432-0697" + ], + "website": "http://campuspress.yale.edu/dok3/home/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-14-1517858697.jpg?itok=ry4-zVQS", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Morgan Knuesel", + "profile_link": "https://physics.yale.edu/people/morgan-knuesel", + "title": "Graduate School Student", + "office": "WLW-309", + "email": "morgan.knuesel@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4721-1693937054.png?itok=lUw7Y1uC", + "field_of_study": "Nuclear PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Steven Konezny", + "profile_link": "https://physics.yale.edu/people/steven-konezny", + "title": "Associate Research Scientist in Chemistry and Physics", + "office": "520 West Campus Drive, Energy Sciences Center I (B22), rm. 130", + "email": "steven.konezny@yale.edu", + "phones": [ + "+1 (203) 737-3287" + ], + "website": "http://konezny.sites.yale.edu", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3360-1564771408.jpg?itok=dJPAk_dY", + "field_of_study": "", + "profile_bio": null, + "website_text": "Associate Research Scientist in the Chemistry and Physics departments Education:  Physics Ph.D., University of Rochester Field of Study:  Physics of charge transport After completing his undergraduate degree in physics from Vassar College, Steve Konezny earned his Ph.D. from University of Rochester and held postdoctoral positions at EPFL in Lausanne, Switzerland and at Yale University.  Since 2010 he has been an Associate Research Scientist at Yale, where he is a member of the Chemistry and Physics departments and maintains a research lab in the Yale Energy Sciences Institute. Dr. Konezny’s career has focused on research involving experimental and theoretical studies of energy-relevant materials and devices.  This work comprises a multi-scale approach aimed at understanding the fundamental physics of charge transport, improving device models through concerted simulation and experimental device characterization, and designing novel systems for efficient solar energy conversion." + }, + { + "name": "Brian Koopman", + "profile_link": "https://physics.yale.edu/people/brian-koopman", + "title": "Associate Research Scientist", + "office": "WLC 258A", + "email": "brian.koopman@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3156-1533570889.jpg?itok=6lKxgo91", + "field_of_study": "Astrophysics & Cosmology", + "profile_bio": null, + "website_text": null + }, + { + "name": "Claire Laffan", + "profile_link": "https://physics.yale.edu/people/claire-laffan", + "title": "Graduate School Student", + "office": "claire.laffan@yale.edu", + "email": "claire.laffan@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3784-1656616678.png?itok=P1XRR8oN", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Steve Lamoreaux", + "profile_link": "https://physics.yale.edu/people/steve-lamoreaux", + "title": "Eugene Higgins Professor of Physics", + "office": "SPL 61 / WL-EAL 326", + "email": "steve.lamoreaux@yale.edu", + "phones": [ + "203-432-5276" + ], + "website": "http://www.yale.edu/lamoreauxgroup/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-121-1666298617.jpg?itok=5x4Ck30s", + "field_of_study": "AMOExperimentalistHaloscope At Yale Sensitive to Axion CDM (HAYSTAC), Electric dipole moment, Casimir effect", + "profile_bio": "Steve Lamoreaux is currently the Principal Investigator for the HAYSTAC dark matter experiment which is based at Yale University, and represents a collaboration between Colorado University, UC Berkeley, and Yale.  This experiment was designed and constructed at Yale beginning in 2010, and has been producing  data for several years.   This detector is among the first (the other is LIGO) to use squeezed quantum states to improve sensitivity beyond the fundamental quantum limit of linear amplifiers.  His other work includes ultracold neutron (UCN) physics and remains involved with the UCN program at Los Alamos National Laboratory and the Spallation Neutron Source at Oak Ridge. He remains interested in quantum computing and cryptography and in the Casimir force, however his efforts in these areas are nowadays directed toward developing advanced student laboratory projects.", + "website_text": "About the Laboratory Current Work: HAYSTAC and ALPHA We are studying the properties of the Universe and the fundamental laws of physics using small-scale tabletop experiments.  The principal activity is presently a search for galactically-bound cold dark matter (CDM), the H aloscope A t Y ale S ensitive T o A xion C DM (HAYSTAC).  This effort is supported by the Heising-Simons Foundation, by the National Science Foundation, and by Yale University. The Phase I HAYSTAC detector system is shown in the photo to the left, with Ben Brubaker (graduate student), Steve Lamoreaux, and Yulia Gurevich (former postdoc, then a Marie Curie Fellow at the University of Heidelberg).  The laboratory is part of the Wright Laboratory of Yale University and is in Room 326 of Wright Lab West. The red can is a cryostat that contains an external-cryogen-free dilution refrigerator which cools the microwave cavity to about 0.12 K. The gray can is a separate cryostat that contains a 9 Tesla superconducting magnet. More details of the experiment are provided on the Research pages of this website. The system was upgraded, incorporating a squeezed state receiver designed by Prof. Konrad Lehnert’s group at Univ. Colorado,  in 2019.  We called this HAYSTAC Phase II.  We also moved the experiment to a Blue Fors LD-250 dilution refrigerator acquired in 2015. This is a photograph of the insert. The very top section carries the dilution refrigerator plumbing, the next section is where the microwave components are mounted.  Underneath this section is an aluminum hoop that carries a superconducting coil that shields the microwave components from the full field of the magnet. The silver can underneath is a multilevel magnetic shield that houses two Josephson Parametric Amplifiers, one serves to generate a squeezed state, while the second is a phase-sensitive amplifier adjusted to amplify the squeezed component. Hanging from the very bottom is the tunable microwave cavity where the axion conversion to photons occurs—the gantry from which the cavity hangs is made of high thermal conductivity copper rods. This is a photograph of the DR/Cavity inserted into the superconducting magnet. The lab has two levels, with the electronics on the upper level, away from the 9 Tesla magnetic field that falls off quite rapidly with distance. Kelly Backes (Ph.D. 2021) is shown adjusting the squeezed state microwave receiver. Other changes include an Attocube piezoelectric motor to adjust the cavity frequency. We are currently in Phase III of HAYSTAC after incorporating further improvements, including parallel processing on an Nvidia graphics card for the Fourier transform of the raw signal. Note from SKL : After seeing the Samuel Beckett play Endgame at the Longwharf Theater in New Haven in Jan. 2017, I realized that I am also in an endgame, cast as Clov and the HAYSTAC detector is Hamm https://www.nhregister.com/entertainment/article/Brian-Dennehy-tackles-his-Matterhorn-11317638.php Previous Efforts In past years, we had two main experimental projects located at Yale. One was a search for the permanent electric dipole moment (EDM) of the electron. The electron EDM can only exist if the laws of physics violate time-reversal and parity symmetries. The existence of such an EDM at a measurable level is predicted by several particle-physics theories beyond the standard model of electroweak interactions, such as Supersymmetry. The other project was a study of the Casimir force. This is a force between two bodies due to quantum vacuum fluctuations around and in between these bodies. We used a torsion pendulum apparatus to study this force under various conditions. The Casimir measurement apparatus is still functional, awaiting a new project." + }, + { + "name": "Joseph Lap", + "profile_link": "https://physics.yale.edu/people/joseph-lap", + "title": "Graduate School Student", + "office": "SPL 52", + "email": "joseph.lap@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3524-1588172964.jpg?itok=drTIFAt0", + "field_of_study": "Particle PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Bjorn Larsen", + "profile_link": "https://physics.yale.edu/people/bjorn-larsen", + "title": "Graduate School Student", + "office": "KT 403", + "email": "bjorn.larsen@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4796-1693937329.png?itok=bKxWpzHq", + "field_of_study": "Astrophysics & Cosmology", + "profile_bio": null, + "website_text": null + }, + { + "name": "Elise Le Boulicaut Ennis", + "profile_link": "https://physics.yale.edu/people/elise-le-boulicaut-ennis", + "title": "Postdoctoral Associate - Physics", + "office": "KT 425", + "email": "elise.leboulicautennis@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5061-1717077876.jpg?itok=UVralKIW", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": "Her research focuses on testing the Standard Model of particle physics, particularly the Higgs boson and how it interacts with tau leptons. She is also involved in the next upgrade of the ATLAS detector for the High-Luminosity LHC phase.", + "website_text": null + }, + { + "name": "Seung Hwan Lee", + "profile_link": "https://physics.yale.edu/people/seung-hwan-lee", + "title": "Postdoctoral Associate", + "office": "YSB C188", + "email": "seunghwan.lee@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5314-1738181254.png?itok=8K6KOqiz", + "field_of_study": "Condensed Matter PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Konrad Lehnert", + "profile_link": "https://physics.yale.edu/people/konrad-lehnert", + "title": "Eugene Higgins Professor of Physics", + "office": "SPL 68A", + "email": "konrad.lehnert@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4947-1737561931.jpg?itok=gNaBT1iW", + "field_of_study": "Condensed Matter PhysicsExperimentalist", + "profile_bio": "In our group, we build electrical and electromechanical machines and coax them into exhibiting quantum behavior. We are motivated by asking: “what is the largest and most tangible object that can be in two places at once?” In addition, we seek to use these machines to store, process, and transmit information in an essentially quantum way. Finally, we develop measurement tools for sensing feeble forces and electrical signals at the limits imposed by quantum mechanics.", + "website_text": null + }, + { + "name": "Matthew Leighton", + "profile_link": "https://physics.yale.edu/people/matthew-leighton", + "title": "Postdoctoral Fellow", + "office": "YSB", + "email": "matthew.leighton@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5316-1754488058.png?itok=uJgYs1f2", + "field_of_study": "Biophysics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Andre Levchenko", + "profile_link": "https://physics.yale.edu/people/andre-levchenko", + "title": "John C. Malone Professor of Biomedical Engineering", + "office": "Systems Biology Institute", + "email": "andre.levchenko@yale.edu", + "phones": [ + "+1 (203) 737-3088" + ], + "website": "https://levchenkolab.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3970-1639064558.jpg?itok=-ACdAmfP", + "field_of_study": "BiophysicsExperimentalistQuantitative analysis of signaling pathways regulating biological phenotype: Signaling Pathway Dynamics, Gradient Sensing, Bacteria-Host Interactions, Differentiation of Stem Cells, Control of Cell Shape & Polarity, Hetertypic Cell Interaction, Networks", + "profile_bio": "Systems Biology; Signal Transduction and Cell-Cell Communication; Cell Decision Making; Microfluidics and Micro- and Nano-fabrication; Stem Cell Engineering", + "website_text": "Welcome to the Levchenko Lab! Interests: Systems Biology; Signal Transduction and Cell-Cell Communication; Cell Decision Making; Microfluidics and Micro- and Nano-fabrication; Stem Cell Engineering Where to find us:" + }, + { + "name": "Benjia Li", + "profile_link": "https://physics.yale.edu/people/benjia-li", + "title": "Graduate School Student", + "office": "benjia.li@yale.edu", + "email": "benjia.li@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4778-1760130073.jpg?itok=Yk_miIto", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Runze Li", + "profile_link": "https://physics.yale.edu/people/runze-li", + "title": "Graduate School Student", + "office": "KT 429", + "email": "runze.li@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4158-1655126134.jpg?itok=noL2cOIO", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Yilin Li", + "profile_link": "https://physics.yale.edu/people/yilin-li", + "title": "Graduate School Student", + "office": "yilin.li@yale.edu", + "email": "yilin.li@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4139-1653668048.jpg?itok=sbv0s_zv", + "field_of_study": "Atomic & Optical PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Ridge Liu", + "profile_link": "https://physics.yale.edu/people/ridge-liu", + "title": "Graduate School Student", + "office": "WLC 254B", + "email": "ridge.liu@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3201-1535124918.jpg?itok=jn82_rtO", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Tongjun Liu", + "profile_link": "https://physics.yale.edu/people/tongjun-liu", + "title": "Postdoctoral Associate", + "office": "YSB-C182", + "email": "tongjun.liu@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5073-1733944253.png?itok=HT-GdiGZ", + "field_of_study": "AMOExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Tony G Liu", + "profile_link": "https://physics.yale.edu/people/tony-g-liu", + "title": "Graduate School Student", + "office": "tony.g.liu@yale.edu", + "email": "tony.g.liu@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4181-1657034462.jpg?itok=zeDBEW8z", + "field_of_study": "Particle PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Charles Lomba", + "profile_link": "https://physics.yale.edu/people/charles-lomba", + "title": "Graduate School Student", + "office": "YSB 154", + "email": "charles.lomba@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3525-1759935225.jpg?itok=os41NL14", + "field_of_study": "Biological Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Francisco Lopez", + "profile_link": "https://physics.yale.edu/people/francisco-lopez", + "title": "Research & Development Technician", + "office": "WL 220C / WLC 255", + "email": "francisco.d.lopez@yale.edu", + "phones": [ + "203-432-6996" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-767-1441732933.jpg?itok=iuR3sA-H", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Cecily Lowe", + "profile_link": "https://physics.yale.edu/people/cecily-lowe", + "title": "Graduate School Student", + "office": "cecily.lowe@yale.edu", + "email": "cecily.lowe@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4779-1693937820.png?itok=aW88bh_c", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Christopher Lynn", + "profile_link": "https://physics.yale.edu/people/christopher-lynn", + "title": "Assistant Professor", + "office": "YSB C147", + "email": "christopher.lynn@yale.edu", + "phones": [], + "website": "https://lynnlab.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4672-1737747307.jpg?itok=29g5ybGf", + "field_of_study": "BiophysicsTheoristStatistical physics of brain networks, information processing in neural populations, network science of complex living systems.", + "profile_bio": "We are interested in understanding how structure and function emerge in complex living systems, particularly the brain. We study how individual neurons interact to form networks; how whole-brain activity orchestrates cognition; and how humans communicate to process information. We approach these problems from a statistical physics perspective: seeking to identify the key minimal ingredients that combine to produce collective macroscopic phenomena.", + "website_text": "How does biological function emerge? Welcome to the SPIN (Statistical Physics, Information & Networks) Lab in the Department of Physics , the Quantitative Biology Institute , and the Wu Tsai Insitute at Yale. We are interested in understanding how structure and function emerge in complex living systems, particularly the brain. We study how individual neurons interact to form networks; how whole-brain activity orchestrates cognition; and how humans communicate to process information. We approach these problems from a statistical physics perspective: seeking to identify the key minimal ingredients that combine to produce collective macroscopic phenomena. [Read more]" + }, + { + "name": "Benjamin Machta", + "profile_link": "https://physics.yale.edu/people/benjamin-machta", + "title": "Associate Professor of Physics", + "office": "YSB-C164", + "email": "benjamin.machta@yale.edu", + "phones": [ + "+1 (203) 432-3650" + ], + "website": "https://machtagroup.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-2486-1649684716.png?itok=69KG0Pc1", + "field_of_study": "Biophysics; Condensed Matter PhysicsTheoristOur research focuses on understanding how biological systems operate using approaches from theoretical physics.  We use statistical physics to understand the structure and function of biological membranes, which experiments have shown operate close to a demixing critical point in the Ising universality class.  They also use tools from information theory to place physical bounds on the ability of organisms to function that arise from their limited ability to measure their environment and from their limited energy budget.", + "profile_bio": "Ben’s research focuses on understanding how biological systems operate using approaches from theoretical physics.  His group uses statistical physics to understand the structure and function of biological membranes, which experiments have shown operate close to a demixing critical point in the Ising universality class.  They also use tools from information theory to place physical bounds on the ability of organisms to function that arise from their limited ability to measure their environment and from their limited energy budget.", + "website_text": "Who we are The group’s research focuses on understanding how biological systems operate using approaches from theoretical physics.  We use statistical physics to understand the structure and function of biological membranes, which experiments have shown operate close to a demixing critical point in the Ising universality class.  We also use tools from information theory to place physical bounds on the ability of organisms to function that arise from their limited ability to measure their environment and from their limited energy budget. We are in the Department of Physics and the QBio Institute at Yale University, located physically in the Yale Science Building (YSB) in the QBio area, C level. Selected Publications Escherichia coli chemotaxis is information limited .  Henry H. Mattingly, Keita Kamino, Benjamin B. Machta, Thierry Emonet. Nature Physics 17 , 1426–1431 (2021). Surface densities prewet a near critical membrane .  Mason Rouches, Sarah L. Veatch, Benjamin B. Machta . Proceedings of the National Academy of Sciences 118 (40) e2103401118 (2021). Irriversibility in dynamical phases and transitions. Daniel S. Seara, Benjamin B. Machta , Michael S. Murrell. Nature Communications 12 392 (2021) pdf Energy Dissipation Bounds in Autonomous Thermodynamic Systems. Samuel J. Bryant, Benjamin B. Machta. Proceedings of the National Academy of Sciences 117 (7), 3478-3483 (2020), pdf Maximizing the information learned from finite data selects a simple model .  Henry H. Mattingly, Mark K. Transtrum, Michael C. Abbott, Benjamin B. Machta. Proceedings of the National Academy of Sciences 115 (8) 1760-1765 (2018), pdf" + }, + { + "name": "Christopher Macias", + "profile_link": "https://physics.yale.edu/people/christopher-macias", + "title": "Associate Research Scientist", + "office": "CERN", + "email": "c.macias@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4856-1701457830.jpg?itok=wfPCBaCf", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": "Chris has been working on the Deep Underground Neutrino Experiment (DUNE) experiment since 2016. His past contribution for the DUNE experiment has been in R&D, commissioning, operations, and data analysis with the Photon Detection system for DUNE’s ProtoDUNE-Single Phase. Currently, his focus is helping facilitate the production and R&D for DUNE’s Far-Detector-2 Vertical-Drift (FD2-VD). Specifically, R&D on the production and installation on the Charge-Readout-Plane (CRP), as well as planning and preparations for the Yale DUNE-CRP factory setup at Wright Lab. Further, Chris is working on the technical coordination of prototypes and anode detector components for FD2-VD for DUNE at CERN.", + "website_text": null + }, + { + "name": "Michael MacKenzie", + "profile_link": "https://physics.yale.edu/people/michael-mackenzie", + "title": "Postdoctoral Associate", + "office": "michael.mackenzie@yale.edu", + "email": "michael.mackenzie@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5318-1738181495.png?itok=NYZWZBla", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Aaron Markowitz", + "profile_link": "https://physics.yale.edu/people/aaron-markowitz", + "title": "Postdoctoral Associate", + "office": "aaron.markowitz@yale.edu", + "email": "aaron.markowitz@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5303-1738173347.jpg?itok=rU-56EFM", + "field_of_study": "Neutrinos & Fundamental Symmetries", + "profile_bio": null, + "website_text": null + }, + { + "name": "Reina Maruyama", + "profile_link": "https://physics.yale.edu/people/reina-maruyama", + "title": "Professor of Physics and Astronomy", + "office": "WL 209", + "email": "reina.maruyama@yale.edu", + "phones": [ + "203-432-3362" + ], + "website": "http://maruyama-lab.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-335-1666298758.jpg?itok=VfFLaDg1", + "field_of_study": "Nuclear Physics; Particle PhysicsExperimentalistCryogenic Underground Observatory for Rare Events (CUORE), IceCube Neutrino Obervatory, CUORE Upgrade with Particle IDentification (CUPID), ATLAS, COSINE-100, DM-Ice, Haloscope At Yale Sensitive To Axion CDM (HAYSTAC)", + "profile_bio": null, + "website_text": "Welcome to the Maruyama-Lab Prof. Maruyama and her group develop technologies for and carry out experiments to probe nature at the most fundamental level. The group studies underlying physics of fundamental symmetries, origins of the universe, and nature of neutrinos and dark matter. We use techniques being developed in the fields of quantum sensor development, atomic, astrophysics, particle, and nuclear physics to solve some of the greatest mysteries of the evolution of the Universe – what is the Universe made of, and why does it have more matter than anti-matter? The group is led by Professor Maruyama and is located in the Department of Physics located at the Wright Laboratory at Yale University . Check out the Research Page to learn more about dark matter, neutrinos, and the research being carried in our lab. Follow Prof. Maruyama and #maruyama_lab on twitter ." + }, + { + "name": "Michael McCrackan", + "profile_link": "https://physics.yale.edu/people/michael-mccrackan", + "title": "Postdoctoral Associate - Physics", + "office": "WLC-258", + "email": "michael.mccrackan@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5247-1729630737.png?itok=hzmGAGaH", + "field_of_study": "Astrophysics & Cosmology", + "profile_bio": "I work with Professor Laura Newburgh in Cosmology and Cosmic Microwave Background science. I am a member of the Simons Observatory (SO) Collaboration, where my focus is on analyzing the time-ordered data for both the Small Aperture Telescopes (SAT) and the Large Aperture Telescope (LAT) while developing and optimizing the data reduction algorithms of the SO time-ordered data reduction pipeline (sotodlib/so3g).", + "website_text": null + }, + { + "name": "Seraphim McGann", + "profile_link": "https://physics.yale.edu/people/seraphim-mcgann", + "title": "Linux, Technical Support", + "office": "WL 239", + "email": "seraphim.mcgann@yale.edu", + "phones": [ + "203-432-5194" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5190-1738169980.png?itok=n4oXG4lu", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Erin McGee", + "profile_link": "https://physics.yale.edu/people/erin-mcgee", + "title": "Graduate School Student", + "office": "erin.mcgee@yale.edu", + "email": "erin.mcgee@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5463-1752612221.jpg?itok=YfvCYuXG", + "field_of_study": "AMOExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Dan McGurk", + "profile_link": "https://physics.yale.edu/people/dan-mcgurk", + "title": "Senior Administrative Assistant", + "office": "WL 220", + "email": "daniel.mcgurk@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5500-1757352001.jpg?itok=YJpDdBjU", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Rohin McIntosh", + "profile_link": "https://physics.yale.edu/people/rohin-mcintosh", + "title": "Graduate School Student", + "office": "rohin.mcintosh@yale.edu", + "email": "rohin.mcintosh@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3865-1630416332.jpg?itok=57BSdB7p", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Siddhant Mehrotra", + "profile_link": "https://physics.yale.edu/people/siddhant-mehrotra", + "title": "Graduate School Student", + "office": "siddhant.mehrotra@yale.edu", + "email": "siddhant.mehrotra@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5105-1722263359.png?itok=yGBCOnO6", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Cyril Metzger", + "profile_link": "https://physics.yale.edu/people/cyril-metzger", + "title": "Postdoctoral Associate", + "office": "YSB C188", + "email": "cyril.metzger@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5320-1738181660.jpg?itok=PXVtDjXk", + "field_of_study": "Condensed Matter PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Allen Mi", + "profile_link": "https://physics.yale.edu/people/allen-mi", + "title": "Graduate School Student", + "office": "allen.mi@yale.edu", + "email": "allen.mi@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4781-1733944291.png?itok=WPnyDtj3", + "field_of_study": "Quantum Information PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Owen Miller", + "profile_link": "https://physics.yale.edu/people/owen-miller", + "title": "Assistant Professor of Applied Physics", + "office": "BCT 313 & ESC II 141", + "email": "owen.miller@yale.edu", + "phones": [ + "+1 (203) 737-6680" + ], + "website": "http://millergroup.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3944-1759859414.png?itok=XApglLAU", + "field_of_study": "Atomic, Molecular & Optical PhysicsTheoristBounds on wave scattering, Computational design, Near-field optical physics, Optimal nanoparticle scatterers, Solar cell design principles", + "profile_bio": "The Miller Group specializes in design and optimization of wave systems at the micro and nanoscales. We use computation and theory, aiming to open the design space–in photonics, elastodynamics, and more general wave systems–through two approaches:  (1) efficiently exploring high-dimensional spaces via large-scale computational optimization, and (2) developing analytical techniques to model new phenomena and discover fundamental response limits. We apply these techniques to application areas including photovoltaics, near-field optics, nanoparticle scatterers, thermal radiation, and more. Our goal is to describe and discover fundamental device performance limits, and to design devices approaching those limits.", + "website_text": "Welcome! The Miller Group specializes in design and optimization of wave systems at the micro and nanoscales, especially for energy applications (e.g. photovoltaics). Our primary interests are in designing device performance to approach limits set by fundamental physical principles, as well as discovering those limits ourselves. We leverage computation and analytical theory in our work, while collaborating with groups at Yale and beyond to experimentally test and verify our ideas. Take a look at our Research page to learn more! We are in Yale’s Applied Physics department and are affiliated with the Energy Sciences Institute, alongside faculty from diverse departments including chemistry, mechanical engineering, and chemical and environmental engineering. We are actively recruiting graduate students and post-docs – come join us!" + }, + { + "name": "Chiara Mingarelli", + "profile_link": "https://physics.yale.edu/people/chiara-mingarelli", + "title": "Assistant Professor", + "office": "KT 445", + "email": "chiara.mingarelli@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4664-1737490508.jpg?itok=inSF9ayU", + "field_of_study": "Astrophysics & CosmologyTheoristNANOGrav Collaboration", + "profile_bio": "Prof. Mingarelli is an astrophysicist who models the cosmic population of supermassive black hole binary mergers. Gas and stars interact with black holes, and those interactions can leave distinctive imprints in their gravitational wave signatures. These individual systems create a gravitational wave background, and she predicts how those astrophysical signatures manifest. Specifically, Mingarelli is best known for her work on predicting and modeling anisotropy in the gravitational-wave background (e.g. Mingarelli et al. 2013), multimessenger astrophysics (e.g. Mingarelli et al. 2017 and Xin, Mingarelli, Hazboun 2021), and extracting properties of the cosmic population of supermassive black hole binaries for the amplitude of the gravitational wave background (Casey-Clyde, Mingarelli, et al. 2022).", + "website_text": null + }, + { + "name": "Victoria Misenti", + "profile_link": "https://physics.yale.edu/people/victoria-misenti", + "title": "Program Manager Wright Lab", + "office": "WL 220C", + "email": "victoria.misenti@yale.edu", + "phones": [ + "+1 (203) 432-7763" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-2501-1666371284.jpg?itok=mR3wo53M", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Simon Mochrie", + "profile_link": "https://physics.yale.edu/people/simon-mochrie", + "title": "Professor of Physics & Applied Physics", + "office": "SPL 68C", + "email": "simon.mochrie@yale.edu", + "phones": [ + "203-436-4809, 203-432-4086" + ], + "website": "http://mochrielab.yale.edu", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-123-1622209750.jpg?itok=G1vUSupd", + "field_of_study": "Biophysics; Condensed Matter PhysicsExperimentalistSingle Molecule Optical Tweezers Measurement on Nucleosomes, Fast Scanning Random Access STED Microscopy, Protein Degradation in Yeast, The Role of Peripheral Chromatin in Nuclear Mechanics", + "profile_bio": null, + "website_text": "We apply physical techniques to study biological interactions. Currently our primary approach is optical tweezers where we apply a variety of techniques, including tethered particle motion, flow-forces, magnetic tweezers, and single-molecule fluorescence. We are now building a novel STED microscope to be used in the near future to study biological systems such as the ubiquitin-proteasome system in S. cerevisiae . Despite focusing heavily on instrumentation, our primary goal is to measure and understand underlying biological mechanisms." + }, + { + "name": "Asheesh Momi", + "profile_link": "https://physics.yale.edu/people/asheesh-momi", + "title": "Graduate School Student", + "office": "YSB-C164", + "email": "asheesh.momi@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3527-1610629401.jpg?itok=8dfCcTY7", + "field_of_study": "Biological Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Vincent Moncrief", + "profile_link": "https://physics.yale.edu/people/vincent-moncrief", + "title": "Professor of Physics and of Mathematics", + "office": "KT 413", + "email": "vincent.moncrief@yale.edu", + "phones": [ + "+1 (203) 432-8283" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-124-1357316504.jpg?itok=MzcCmCQS", + "field_of_study": "Gravitational PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Toni Montalvo", + "profile_link": "https://physics.yale.edu/people/toni-montalvo", + "title": "Graduate Student", + "office": "SPL-12", + "email": "toni.montalvo@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3866-1630416378.jpg?itok=63u8AN3_", + "field_of_study": "Atomic & Optical PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Isaac Mooney", + "profile_link": "https://physics.yale.edu/people/isaac-mooney", + "title": "Postdoctoral Associate", + "office": "WLW-308", + "email": "isaac.mooney@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4276-1664474032.jpg?itok=YzmGJEq9", + "field_of_study": "Nuclear PhysicsExperimentalist", + "profile_bio": "One of the focuses of the STAR experiment at the Relativistic Heavy Ion Collider has been the interaction of high-energy final-state partons with the hot, colored QCD medium created in collisions of heavy nuclei like gold. This interaction can be measured indirectly as a modification to the eventual collimated fragmentation products called jets. Before these jets can be used as a tomographic probe of the microscopic structure of the quark-gluon plasma (QGP), the baseline must be calibrated. For this reason, my dissertation research focused on measurements of jet substructure in smaller systems: proton-proton and proton-gold. This will allow for a future measurement of the modification due entirely to the presence of the QGP, resulting in an improved understanding of the jet-medium interactions at RHIC kinematics. In 2022, excellent work (Phys. Rev. C 105, 044906) from the STAR collaboration suggested that at RHIC, the earliest hard partonic splittings either occur outside of the medium or are not resolved by the QGP. I am interested in following this up by looking into the timing of splits in or outside of the medium and the substructure of jets with splittings resolved or not resolved by the medium.", + "website_text": null + }, + { + "name": "David Moore", + "profile_link": "https://physics.yale.edu/people/david-moore", + "title": "Associate Professor of Physics", + "office": "WL 208", + "email": "david.c.moore@yale.edu", + "phones": [ + "+1 203-432-7986" + ], + "website": "http://campuspress.yale.edu/moorelab/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-886-1472129148.jpg?itok=j3ZQc2Vs", + "field_of_study": "Nuclear Physics; Particle PhysicsExperimentalistnEXO, Search for new Interactions in a Microshere Precision Levitation Experiment (SIMPLE)", + "profile_bio": "Professor Moore’s research group is developing new technologies to search for physics beyond the Standard Model of particle physics.  These experiments use precision techniques to search for tiny effects in the lab, including new fundamental phenomena (e.g., those related to neutrinos, dark matter, or the microscopic nature of gravity) that may occur at much higher energy or much weaker couplings than could be directly detected at particle accelerators or other direct searches.  We are currently involved in searching for neutrinoless double beta decay with the nEXO experiment, which aims to identify this lepton-number-violating decay if it occurs with a half-life up to 10 28 years (nearly 10 18 times the age of the universe).  We are also developing force sensors and accelerometers capable of searching for new forces (as small as 10 -21 N) using optically trapped, nanogram scale masses.  These optomechanical sensors have applications to searches for dark matter, tests of Newton’s and Coulomb’s laws at microscopic distances, and are approaching quantum measurement regimes for nanogram mass mechanical objects. Professor Moore’s research group is housed at  Professor Moore’s research group is housed at Wright Laboratory and Prof. Moore is a member of the Yale Quantum Institute .", + "website_text": null + }, + { + "name": "Maya Moore", + "profile_link": "https://physics.yale.edu/people/maya-moore", + "title": "Graduate School Student", + "office": "maya.moore@yale.edu", + "email": "maya.moore@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4167-1657111655.jpg?itok=gjY99j5N", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Peter Morgan", + "profile_link": "https://physics.yale.edu/people/peter-morgan", + "title": "Lab Associate", + "office": "peter.w.morgan@yale.edu", + "email": "peter.w.morgan@yale.edu", + "phones": [ + "203-495-8766" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-163-1525094036.jpg?itok=ZrVUq7TZ", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Thomas Morris", + "profile_link": "https://physics.yale.edu/people/thomas-morris", + "title": "Graduate School Student", + "office": "thomas.w.morris@yale.edu", + "email": "thomas.w.morris@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5322-1738181774.png?itok=GBMhyuAy", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Harvey Moseley", + "profile_link": "https://physics.yale.edu/people/harvey-moseley", + "title": "Visiting Fellow", + "office": "WL", + "email": "samuel.moseley@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4661-1683301847.jpg?itok=WyQP7N11", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Ian Moult", + "profile_link": "https://physics.yale.edu/people/ian-moult", + "title": "Assistant Professor", + "office": "SPL 52A", + "email": "ian.moult@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3851-1724699148.jpg?itok=1khQUukA", + "field_of_study": "Particle PhysicsTheorist", + "profile_bio": "Professor Moult’s research is focused on developing new techniques in quantum field theory for describing high energy particle physics experiments, ranging from Dark Matter detection to the Large Hadron Collider (LHC). A common theme in his work is the use of Effective Field Theories, which allow calculations relevant for complicated real world experiments to be reduced to simpler, universal problems in quantum field theory. In addition to the development of new theoretical frameworks, Professor Moult is also interested in exploiting theoretical advances to enable innovative new experimental strategies. Most recently, he has played a leading role in the development of Jet Substructure, which takes advantage of subtle patterns in the structure of energy flow in collisions at the LHC to maximize the discovery potential for new physics, and to better understand the theory of the strong interactions.", + "website_text": null + }, + { + "name": "Berndt Mueller", + "profile_link": "https://physics.yale.edu/people/berndt-mueller", + "title": "Visiting Professor", + "office": "berndt.mueller@yale.edu", + "email": "berndt.mueller@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3989-1642088519.jpg?itok=he-tcR1f", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Siddharth Mukherjee", + "profile_link": "https://physics.yale.edu/people/siddharth-mukherjee", + "title": "Graduate School Student", + "office": "siddharth.mukherjee@yale.edu", + "email": "siddharth.mukherjee@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5106-1722263386.png?itok=jN2lO7TP", + "field_of_study": "Atomic, Molecular, and Optical PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Zach Muraskin", + "profile_link": "https://physics.yale.edu/people/zach-muraskin", + "title": "Graduate School Student", + "office": "zach.muraskin@yale.edu", + "email": "zach.muraskin@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5464-1750792153.png?itok=BoT5egRx", + "field_of_study": "Particle Physics, NeutrinosExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Michael Murrell", + "profile_link": "https://physics.yale.edu/people/michael-murrell", + "title": "Associate Professor of Biomedical Engineering & Physics", + "office": "Systems Biology Institute, 850 West Campus Drive, Rm 359", + "email": "michael.murrell@yale.edu", + "phones": [ + "+1 (203) 737-6618" + ], + "website": "http://livingmatter.yale.edu", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-2571-1518616658.jpg?itok=3OG-evjQ", + "field_of_study": "BiophysicsExperimentalistStochastic Non-Equilibrium Thermodynamics, Experimental BiologicalDe NovoAssembly, Mechanics of ‘Active’ Interfaces, Active Wetting of Living Cells & Tissues", + "profile_bio": null, + "website_text": "Welcome to the Laboratory of Living Matter at Yale University! We are interdisciplinary scientists using tools from soft matter physics and synthetic biology to investigate how the physical properties of cells influences fundamental life processes.  We are particularly interested in how cells sense, produce, and transmit mechanical forces.  In addition to using novel methods to measure the forces generated by living cells, we also design and engineer biomimetic models of cells and tissues from scratch.  These models are built from purified cytoskeletal proteins and membrane components.  Thus, we create 'bottom-up' non-living models which can reproduce mechanical force generation and perform some of the physical behaviors of the cell. Recently we have been interested in using molecular dynamic simulation to explore how cytoskeletal networks store and dissipate energy. We are located at the Yale Systems Biology Institute .  We are part of the Physics Department , Biomedical Engineering Department and the Molecular, Cellular and Developmental Biology (MDCB) Track.  We are also part of the Physical Engineering and Biology (PEB) Program. We are looking for motivated PhD students and Postdocs.  Please contact us if you are interested! Tweets by murrell_lab" + }, + { + "name": "Nayan Myerson-Jain", + "profile_link": "https://physics.yale.edu/people/nayan-myerson-jain", + "title": "Yale Prize Postdoctoral Fellowship", + "office": "SPL 54", + "email": "nayan.myerson-jain@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5502-1757511103.jpg?itok=DxhB0i_W", + "field_of_study": "Condensed MatterTheorist", + "profile_bio": "I mainly study quantum criticality and critical phenomena, as well as information-theoretic properties of quantum many-body systems. Recently, I have been especially involved in studying new physics that may arise at boundaries or defects of quantum critical points, where gapless fluctuations in the bulk lead to novel universality classes of these impurities. Additionally, I am interested in the entanglement properties of quantum many-body systems under noise and measurement, as well as the classification of mixed-state phases more broadly.", + "website_text": null + }, + { + "name": "Pranab Kumar Nag", + "profile_link": "https://physics.yale.edu/people/pranab-kumar-nag", + "title": "Associate Resarch Scientist", + "office": "West Campus Energy Sciences Ctr", + "email": "pranab.nag@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4538-1733944328.png?itok=vlbplFzg", + "field_of_study": "Condensed Matter PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Daisuke Nagai", + "profile_link": "https://physics.yale.edu/people/daisuke-nagai", + "title": "Professor of Physics and of Astronomy", + "office": "KT 451", + "email": "daisuke.nagai@yale.edu", + "phones": [ + "203-909-4266" + ], + "website": "http://www.astro.yale.edu/nagai", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-125-1758898660.jpg?itok=QuFeqLhc", + "field_of_study": "Astrophysics & CosmologyTheoristTheoretical & Computational Cosmology: Dark Matter, Dark Energy, Galaxy Clusters, Galaxy Formation & Evolution, Cosmological Simulations, Data Science", + "profile_bio": "Professor Nagai’s research interests lie in the area of cosmology and astrophysics, specializing in theoretical and computational modeling of the structure formation of the Universe and its application to cosmology. His research group develops and uses theoretical and computational models of how galaxies and clusters of galaxies form and grow in the Universe starting from the Big Bang to today.", + "website_text": null + }, + { + "name": "Mahathi Narayanaswamy", + "profile_link": "https://physics.yale.edu/people/mahathi-narayanaswamy", + "title": "Graduate School Student", + "office": "mahathi.narayanaswamy@yale.edu", + "email": "mahathi.narayanaswamy@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4782-1693938101.png?itok=AvS6Iqx9", + "field_of_study": "BiophysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Priyamvada Natarajan", + "profile_link": "https://physics.yale.edu/people/priyamvada-natarajan", + "title": "Joseph S. and Sophia S. Fruton Professor of Astronomy and Professor of Physics; Chair Astronomy; Chair Women Faculty Forum", + "office": "STN 217", + "email": "priyamvada.natarajan@yale.edu", + "phones": [ + "203-436-4833" + ], + "website": "https://campuspress.yale.edu/priya/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-126-1661177942.jpg?itok=wC0ry3VX", + "field_of_study": "Astrophysics & CosmologyExperimentalistGravitational Lensing, Clusters of Galaxies as Astrophysical Laboratories, Black Hole Physics, Binary Black Holes, Issues in Galaxy Formation, History & Philosophy of Science", + "profile_bio": null, + "website_text": null + }, + { + "name": "Nir Navon", + "profile_link": "https://physics.yale.edu/people/nir-navon", + "title": "Associate Professor of Physics", + "office": "Sloane Physics Laboratory 50A", + "email": "nir.navon@yale.edu", + "phones": [ + "+1 (203) 436-4997" + ], + "website": "https://uqm.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-1116-1482266026.jpg?itok=tR3phoEr", + "field_of_study": "Atomic, Molecular & Optical PhysicsExperimentalistUltracold Quantum Matter", + "profile_bio": "Nir Navon’s research focuses on various aspects of the quantum many-body problem; his lab uses synthetic ultracold matter in programmable traps as a versatile experimental platform for this exploration. His lab’s interests revolve around two broad axes: the study of the emergence of order and collective phenomena in homogeneous quantum matter, and the understanding of far-from-equilibrium turbulent dynamics of quantum fluids.", + "website_text": "Welcome to the Ultracold Quantum Matter Lab website! Some of the most puzzling open problems in modern physics involve the behavior of assemblies of many interacting quantum particles. Our research group at Yale University specializes in the study of this quantum many-body problem using highly-controllable ultracold quantum matter. We aim at improving our understanding of quantum phases of strongly-correlated matter, and explore the emergence of universal states in far-from-equilibrium quantum dynamics." + }, + { + "name": "Layla Nayar", + "profile_link": "https://physics.yale.edu/people/layla-nayar", + "title": "Administrative Services Supervisor", + "office": "SPL 31", + "email": "layla.nayar@yale.edu", + "phones": [ + "+1 (203) 4326167" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5378-1742907789.jpg?itok=hLCtYJ49", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Andrew Neely", + "profile_link": "https://physics.yale.edu/people/andrew-neely", + "title": "Graduate School Student", + "office": "SPL 17", + "email": "andrew.neely@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4169-1656507800.jpg?itok=mcCvp--3", + "field_of_study": "AMOExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Andrew Neitzke", + "profile_link": "https://physics.yale.edu/people/andrew-neitzke", + "title": "Professor of Mathematics", + "office": "DL 425", + "email": "andrew.neitzke@yale.edu", + "phones": [ + "203-432-7057" + ], + "website": "https://gauss.math.yale.edu/~an592/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3895-1631289996.jpg?itok=4dC96LP6", + "field_of_study": "Particle PhysicsTheoristProblems in string theory and supersymmetric field theory", + "profile_bio": "I work on problems in string theory and supersymmetric field theory, usually ones which have some overlap with geometry.", + "website_text": null + }, + { + "name": "Laura Newburgh", + "profile_link": "https://physics.yale.edu/people/laura-newburgh", + "title": "Associate Professor of Physics", + "office": "WL 210", + "email": "laura.newburgh@yale.edu", + "phones": [ + "203-432-9168", + "203-432-3522" + ], + "website": "http://campuspress.yale.edu/newburgh/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-1111-1666298900.jpg?itok=EeqGj7TM", + "field_of_study": "Astrophysics & Cosmology; Particle PhysicsExperimentalist21cm Radio Instrumentation to measure Large Scale Structure and Dark Energy - Canadian Hydrogen Intensity Mapping Experiment (CHIME), The Hydrogen Intensity Mapping and Real-time Analysis eXperiment (HIRAX)Early Universe Cosmology: The Cosmic Microwave Background - Atacama Cosmology Telescope (ACT), Simons Observatory", + "profile_bio": null, + "website_text": null + }, + { + "name": "Alan Nguyen", + "profile_link": "https://physics.yale.edu/people/alan-nguyen", + "title": "Graduate School Student", + "office": "alan.nguyen@yale.edu", + "email": "alan.nguyen@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5107-1722263456.png?itok=wm942w70", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "David Nguyen", + "profile_link": "https://physics.yale.edu/people/david-nguyen", + "title": "Graduate School Student", + "office": "david.nguyen@yale.edu", + "email": "david.nguyen@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3867-1630416425.jpg?itok=3j2g1che", + "field_of_study": "Astrophysics/Cosmology", + "profile_bio": null, + "website_text": null + }, + { + "name": "Farnik Nikakhtar", + "profile_link": "https://physics.yale.edu/people/farnik-nikakhtar", + "title": "YCAA Postdoctoral Fellow", + "office": "KT 435", + "email": "farnik.nikakhtar@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4215-1660319954.jpg?itok=rhmSKtm7", + "field_of_study": "Astrophysics & Cosmology", + "profile_bio": "The two dominant components of the universe, dark energy (~70%) and dark matter (~30%) remain among the most mysterious concepts in physics today. The effects of these two substances are imprinted in the remaining few percent of the universe that consists of baryonic matter. I have divided my research with a similar proportion into ideas that address the observable effects of both these phenomena. I have spent ~70% of my time studying observational and theoretical aspects of Baryon Acoustic Oscillations (BAO) by which we can measure the expansion rate of the universe and constrain dark energy. The other ~30% of my research focuses on ways to probe the nature of dark matter by studying the dynamics of galaxies and the orbital properties of their stars. From the theoretical side, I am interested in Optimal Transport Theory and the fundamental connections this theory has with the physical questions from galactic to cosmological scales. Many decisions in science and life are based on the shortest path principle, which states that there should be a minimum amount of effort required to transport an object from one point to another. This intuition is generalized in optimal transport theory when, rather than moving only one item at a time, the problem is to move several items simultaneously (or a continuous distribution) from one configuration to another. I have utilized this general concept to answer a number of questions relevant to both the BAO and Galactic Dynamics fields and this is the thread that unites my research.", + "website_text": null + }, + { + "name": "Gaurav Nirala", + "profile_link": "https://physics.yale.edu/people/gaurav-nirala", + "title": "Postdoctoral Associate", + "office": "YSB-C182", + "email": "gaurav.nirala@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5076-1729867276.png?itok=Wo0aFted", + "field_of_study": "AMOExperimentalist", + "profile_bio": "Experimental Quantum Optics and Optomechanics. Have extensive research experience in quantum optics focusing on entanglement and spatial correlations.", + "website_text": null + }, + { + "name": "Paul Noel", + "profile_link": "https://physics.yale.edu/people/paul-noel", + "title": "Interim Manager, Instructional Labs", + "office": "SCL 106", + "email": "paul.noel@yale.edu", + "phones": [ + "+1 (989) 450-9465", + "203-432-6175" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-734-1437421717.jpg?itok=F94_SXxG", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Corey O'Hern", + "profile_link": "https://physics.yale.edu/people/corey-ohern", + "title": "Professor of Mechanical Engineering", + "office": "ML 203", + "email": "corey.ohern@yale.edu", + "phones": [ + "+1 (203) 432-4258" + ], + "website": "http://jamming.research.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-127-1575476853.jpg?itok=EIiD65GI", + "field_of_study": "Biophysics; Condensed Matter PhysicsTheoristSoft Matter Research: Quasi-one dimensional models for glassy behavior, the connection between percolation in configuration space and glassy dynamics, statistical mechanics of static and slowly flowing granular media, jamming in systems composed of anisotropic particles and with polymer constraintsBiological Physics Research: Smart, designer, protein-based nanogels; understanding the structural and mechanical properties of epithelial cells, Nanoscale approaches to screening small molecule inhibitors of toxic amyloid species in neurogegenerative disease; protein folding and misfolding", + "profile_bio": null, + "website_text": null + }, + { + "name": "Brett Oertel", + "profile_link": "https://physics.yale.edu/people/brett-oertel", + "title": "Graduate School Student", + "office": "brett.oertel@yale.edu", + "email": "brett.oertel@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4783-1693938307.png?itok=v-2gv3-d", + "field_of_study": "Particle PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Chin Yuan Ong", + "profile_link": "https://physics.yale.edu/people/chin-yuan-ong", + "title": "Graduate School Student", + "office": "chinyuan.ong@yale.edu", + "email": "chinyuan.ong@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4784-1693938474.png?itok=vHSDfAaa", + "field_of_study": "BiophysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Jennifer Ongley", + "profile_link": "https://physics.yale.edu/people/jennifer-ongley", + "title": "Chair's Assistant", + "office": "SPL 34", + "email": "jennifer.ongley@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4641-1682710287.jpg?itok=cPgey-Ep", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Xiaowei Ou", + "profile_link": "https://physics.yale.edu/people/xiaowei-ou", + "title": "Graduate School Student", + "office": "WC Energy Sciences Ctr", + "email": "xiaowei.ou@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3868-1630416480.jpg?itok=EHxeBJQT", + "field_of_study": "Condensed Matter PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Xiaoyi Ouyang", + "profile_link": "https://physics.yale.edu/people/xiaoyi-ouyang", + "title": "Graduate School Student", + "office": "xiaoyi.ouyang@yale.edu", + "email": "xiaoyi.ouyang@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3529-1630416521.jpg?itok=_BGV9eth", + "field_of_study": "Biological Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Vidvuds Ozolins", + "profile_link": "https://physics.yale.edu/people/vidvuds-ozolins", + "title": "Tom Steyer and Kat Taylor Professor of Clean Energy Solutions", + "office": "Main Campus Office: 15 Prospect Street, BCT 305, New Haven, CT 06511. West Campus Office: Yale Energy Sciences Institute, 810 West Campus Drive E137 West Haven, CT 06516", + "email": "vidvuds.ozolins@yale.edu", + "phones": [ + "+1 (203) 737-3828" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4575-1677773638.jpg?itok=M9VIznWn", + "field_of_study": "", + "profile_bio": "Our research interests are in the field of first-principles computational modeling of high-performance materials. We use and develop theoretical methods for quantum mechanical calculations based on the density functional theory (DFT) and beyond, as well as modern statistical simulation methods, such as Monte Carlo, molecular dynamics, and path integral molecular dynamics. One of the main themes of our research is to incorporate recent developments in applied mathematics and machine learning to create rigorous, efficient and highly automated high-throughput methods and to apply them to design and discover materials with exceptional technological properties. Topics of interest in our group include, but are not limited to: High-performance materials for energy storage and generation (supercapacitors, batteries, thermoelectrics, solar cells, solar thermochemical conversion, etc.) Thermodynamic, structural and dynamical properties of solids at high temperatures Spin liquid materials for topological quantum computing Electron and phonon transport in bulk materials and nanostructures Thermoelectric phenomena, Seebeck and Peltier effects Compressive sensing and machine learning for building efficient computational models of materials Mathematical approaches for solving partial differentia equations of quantum mechanics and materials science that exploit inherent sparsity", + "website_text": null + }, + { + "name": "Nikhil Padmanabhan", + "profile_link": "https://physics.yale.edu/people/nikhil-padmanabhan", + "title": "Associate Professor of Physics", + "office": "KT 449", + "email": "nikhil.padmanabhan@yale.edu", + "phones": [ + "203-432-9950" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-128-1357317205.jpg?itok=JAR-Pr4I", + "field_of_study": "Astrophysics & CosmologyTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Joy Pajarla", + "profile_link": "https://physics.yale.edu/people/joy-pajarla", + "title": "Graduate School Student", + "office": "joy.pajarla@yale.edu", + "email": "joy.pajarla@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3869-1630417393.jpg?itok=4L2xyDAY", + "field_of_study": "Biological Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Ornella Palamara", + "profile_link": "https://physics.yale.edu/people/ornella-palamara", + "title": "Professor (Adjunct) of Physics", + "office": "Fermilab and Laboratori Nazionali del Gran Sasso", + "email": "ornella.palamara@yale.edu", + "phones": [ + "475-201-6480" + ], + "website": "http://hep.yale.edu/people/ornella-palamara", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-757-1738172196.jpg?itok=PfTJORF8", + "field_of_study": "Neutrinos and Fundamental Symmetries; Elementary Particles", + "profile_bio": null, + "website_text": "Professor (Adjunct) of Physics" + }, + { + "name": "Evan Papoutsis", + "profile_link": "https://physics.yale.edu/people/evan-papoutsis", + "title": "Graduate School Student", + "office": "evan.papoutsis@yale.edu", + "email": "evan.papoutsis@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4785-1693938602.png?itok=DatH9rlV", + "field_of_study": "Applied PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Jacob Paras", + "profile_link": "https://physics.yale.edu/people/jacob-paras", + "title": "Graduate School Student", + "office": "jacob.paras@yale.edu", + "email": "jacob.paras@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5465-1751480847.jpg?itok=6OlNQBev", + "field_of_study": "", + "profile_bio": "I am interested in computational techniques for gravitational wave astrophysics, cosmological simulations, and particle physics — particularly machine learning, quantum computing, and high-performance computing.", + "website_text": null + }, + { + "name": "Peter Parker", + "profile_link": "https://physics.yale.edu/people/peter-parker", + "title": "Professor Emeritus of Physics & Astronomy", + "office": "WL 237", + "email": "peter.parker@yale.edu", + "phones": [ + "203-432-3099" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-129-1666371054.jpg?itok=-4iOtCeg", + "field_of_study": "Nuclear Astrophysics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Siddhi Patel", + "profile_link": "https://physics.yale.edu/people/siddhi-patel", + "title": "Graduate School Student", + "office": "siddhi.patel@yale.edu", + "email": "siddhi.patel@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5108-1722263510.png?itok=crGUDLvZ", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Yashvi Patel", + "profile_link": "https://physics.yale.edu/people/yashvi-patel", + "title": "Graduate School Student", + "office": "yashvi.patel@yale.edu", + "email": "yashvi.patel@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5109-1722263537.png?itok=60ZgMLdm", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Yogesh Patil", + "profile_link": "https://physics.yale.edu/people/yogesh-patil", + "title": "Research Scientist", + "office": "WL 327", + "email": "yogesh.patil@yale.edu", + "phones": [ + "+1 6465359771" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3121-1533133718.jpg?itok=r6RaE71l", + "field_of_study": "AMOExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Alessandro Peca", + "profile_link": "https://physics.yale.edu/people/alessandro-peca", + "title": "Laboratory Associate", + "office": "KT 461", + "email": "ap2874@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5239-1729002673.jpg?itok=f7rcXh1c", + "field_of_study": "Astrophysics & Cosmology", + "profile_bio": "My research focuses on active galactic nuclei (AGN) evolution, with particular interest in obscuration and variability. While my main research is in the X-rays, I also work with optical and infrared data.", + "website_text": null + }, + { + "name": "Gregory Penn", + "profile_link": "https://physics.yale.edu/people/gregory-penn", + "title": "Graduate School Student", + "office": "KT 437", + "email": "gregory.penn@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3870-1630417498.jpg?itok=Y5-H-sAS", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Gianantonio Pezzullo", + "profile_link": "https://physics.yale.edu/people/gianantonio-pezzullo", + "title": "Associate Research Scientist", + "office": "Fermilab", + "email": "g.pezzullo@yale.edu", + "phones": [], + "website": "http://home.fnal.gov/~gianipez/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-2536-1717782543.jpg?itok=XVOOU1NC", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Lily Phillips", + "profile_link": "https://physics.yale.edu/people/lily-phillips", + "title": "Graduate School Student", + "office": "lily.phillips@yale.edu", + "email": "lily.phillips@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5466-1753275604.jpg?itok=rupR-QpY", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Cooper Pich", + "profile_link": "https://physics.yale.edu/people/cooper-pich", + "title": "Graduate School Student", + "office": "cooper.pich@yale.edu", + "email": "cooper.pich@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4786-1693938709.png?itok=i3AHGjpH", + "field_of_study": "Biophysics", + "profile_bio": null, + "website_text": null + }, + { + "name": "David Poland", + "profile_link": "https://physics.yale.edu/people/david-poland", + "title": "Associate Professor of Physics / Director of Undergraduate Studies", + "office": "SPL 53B", + "email": "david.poland@yale.edu", + "phones": [ + "432-6959" + ], + "website": "http://het.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-130-1691432487.jpg?itok=nHGil_VC", + "field_of_study": "Particle Physics; Condensed Matter Physics; Quantum PhysicsTheorist", + "profile_bio": "Professor Poland's research is aimed at developing new nonperturbative methods for quantum field theory, with applications to\nparticle physics, condensed matter physics, and quantum gravity. He is primarily focused on developing both numerical and\nanalytical approaches to conformal field theories using an idea called the ``bootstrap\", which combines constraints from\nsymmetries and unitarity to make predictions for physical observables. This approach has led to precise predictions for critical\nexponents which appear in a variety of physical systems, including water, magnets, and superfuild Helium.\nMore broadly, the bootstrap approach allows one to map out the space of conformal field theories and learn about their\nnonperturbative properties, which can place constraints on scenarios for physics beyond the standard model or the phases of\ncondensed matter systems, teach us about quantum gravity using holography, and act as a discovery tool for identifying new\npreviously‐unknown theories.", + "website_text": "Welcome Our group works on diverse topics in theoretical high energy physics, including physics beyond the Standard Model, field theory, quantum chromodynamics, conformal bootstrap, and early universe physics." + }, + { + "name": "Iris Ponce", + "profile_link": "https://physics.yale.edu/people/iris-ponce", + "title": "Graduate School Student", + "office": "WLW 301", + "email": "iris.ponce@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3530-1666371611.jpg?itok=yM7WZQ1C", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Emily Pottebaum", + "profile_link": "https://physics.yale.edu/people/emily-pottebaum", + "title": "Graduate School Student", + "office": "WLW 301", + "email": "emily.pottebaum@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4163-1713302606.jpg?itok=9YEYzu0J", + "field_of_study": "Heavy IonsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Daniel Prober", + "profile_link": "https://physics.yale.edu/people/daniel-prober", + "title": "Professor of Applied Physics, Physics & Electrical Engineering", + "office": "BCT 417", + "email": "daniel.prober@yale.edu", + "phones": [ + "+1 (203) 432-4280" + ], + "website": "http://appliedphysics.yale.edu/daniel-e-prober", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-131-1451939358.jpg?itok=xDDKJDdH", + "field_of_study": "Condensed Matter PhysicsExperimentalistDynamics of Carbon Nanomaterials, Superconducting Photon Detectors", + "profile_bio": "Experimental solid state physics and superconductivity; coherent quantum transport and noise studies; superconducting quantum detectors: microwave UV and x-ray detectors; nanostructure fabrication techniques. “Energy loss of the electron system in individual single-walled carbon nanotubes,” D.F. Santavicca, J.D. Chudow, D.E. Prober, M.S. Purewal and P. Kim, Nano Lett. 10 , 4538 (2010). [PDF] “Electron coherence and dephasing in metal films, wires and rings”, D.E. Prober, 2010, Invited Chapter in Perspectives on Mesoscopic Physics , eds. A. Aharony and O. Entin-Wohlman, World Scientific Publishing. “Quasiparticle number fluctuations in superconductors”, C.M. Wilson and D.E. Prober, 2004, Phys. Rev. B 69, 094524. [PDF] Nb-Au Bilayer Hot-electron Bolometers for Low-noise THz Heterodyne Detection , Irfan Siddiqi, Daniel E Prober, 2004, Appl. Phys. Lett., 84, 1404. Environmental Effects in the Third Moment of Voltage Fluctuations in a Tunnel Junction , B. Reulet, J. Senzier, Daniel E Prober, 2003, Phys. Rev. Lett., 91, 196601.", + "website_text": null + }, + { + "name": "Shruti Puri", + "profile_link": "https://physics.yale.edu/people/shruti-puri", + "title": "Assistant Professor of Applied Physics", + "office": "YQI", + "email": "shruti.puri@yale.edu", + "phones": [ + "203-436-9329" + ], + "website": "https://purigroup.research.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-2156-1637599144.jpg?itok=wQFRJnqB", + "field_of_study": "Condensed Matter Physics; Quantum PhysicsTheoristQuantum error correction when the noise is biased, Scalable fault-tolerant quantum error correction with bosonic qubits", + "profile_bio": "Theory of quantum information processing and quantum computing, quantum optics, quantum control, quantum error correction, and quantum algorithms.", + "website_text": null + }, + { + "name": "Daniel Qenani", + "profile_link": "https://physics.yale.edu/people/daniel-qenani", + "title": "Graduate School Student", + "office": "daniel.qenani@yale.edu", + "email": "daniel.qenani@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-2991-1723749647.png?itok=uzTx6HEN", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Yutang Qiao", + "profile_link": "https://physics.yale.edu/people/yutang-qiao", + "title": "Graduate School Student", + "office": "yutang.qiao@yale.edu", + "email": "yutang.qiao@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5467-1752510352.png?itok=qqrL6Dz-", + "field_of_study": "", + "profile_bio": "I am interested in condensed matter physics & quantum many body physics.", + "website_text": null + }, + { + "name": "Diana Qiu", + "profile_link": "https://physics.yale.edu/people/diana-qiu", + "title": "Assistant Professor of Mechanical Engineering", + "office": "WC Energy Sciences Ctr", + "email": "diana.qiu@yale.edu", + "phones": [ + "+1 (719) 2106447" + ], + "website": "https://qiugroup.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3479-1583159019.jpg?itok=VWsqlLIm", + "field_of_study": "Condensed Matter Physics; Quantum PhysicsTheoristExciton Transport & Diffusion; Time-Dependent Phenomena; Heterojunctions, Interfaces and Substrates; Defects", + "profile_bio": null, + "website_text": "One of the grand challenges of materials research is the ability to engineer and tune quantum degrees of freedom in order to discover new properties and phenomena, as well as to harness the flow of energy, charge, and information. The discovery and development of these materials must be guided by a deep understanding of how electrons and atoms in these systems behave in response to external stimuli. For instance, what happens when sunlight shines on a solar panel? How much solar energy will be absorbed by the electrons? How far and how fast can they transport that energy, and how can one design materials to optimize that process? A frontier of this understanding and optimization, which is the central goal of our group,  lies in the control of a material’s excitations and macroscopic properties at the quantum level through the tuning of light-matter interactions and many-electron correlations. Our group uses and develops first principles quantum physics methods, which exploit high-performance computing to calculate many-electron interaction effects and make quantitatively accurate predictions about real materials. We are interested in the discovery and design of novel, highly-tunable, and transient materials, as well as the exploration of fundamental processes, such as exciton transport and coherence, and nonlinear and ultrafast optical response in materials relevant to fields such as optoelectronics, quantum information, and energy research." + }, + { + "name": "Bradyn Quintard", + "profile_link": "https://physics.yale.edu/people/bradyn-quintard", + "title": "Graduate School Student", + "office": "bradyn.quintard@yale.edu", + "email": "bradyn.quintard@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5468-1750791877.png?itok=GSGtzZCj", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": "I am interested in experimental particle physics across a range of topics such as QCD and the Quark-Gluon Plasma, neutrinos, and dark matter searches. I am particularly interested in detector physics as it relates to these ongoing projects.", + "website_text": null + }, + { + "name": "David Rabinowitz", + "profile_link": "https://physics.yale.edu/people/david-rabinowitz", + "title": "Senior Research Scientist/Scholar Physics", + "office": "WL 204", + "email": "david.rabinowitz@yale.edu", + "phones": [ + "203-432-3391" + ], + "website": "http://hep.yale.edu/lassilla-quest-variablity-survey", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-165-1738172748.jpg?itok=Y3Fax3Yq", + "field_of_study": "Astrophysics & Cosmology", + "profile_bio": null, + "website_text": "The QUEST Variability Survey studies variable astronomical objects, particularly Kuiper Belt Objects (KBOs), periodic variable stars, and Supernova. The survey utilizes the 40” ESO Schmidt Telescope at the LaSilla Observatory of the European Southern Observatory in Chile  with the new large area QUEST camera, a mossaic of 112 CCD’s covering the full field of view of the telescope (approximately 4 x 4 square degrees), built at Yale University and Indiana University. The camera is installed at the prime focus of the ESO Schmidt Telescope and commissioned in early 2009. The Survey is expected to cover about 1/3 of the full sky (about 15000 square degrees) repeated with roughly 4-day candence. Group Members Science Projects Underway LaSilla Observatory The ESO Schmidt Telescope The Quest Large Area Camera Recent Publications Rabinowitz, David, et al. “The Peculiar Photometric Properties of 2010 WG9: A Slowly Rotating Trans-Neptunian Object from the Oort Cloud.” The Astronomical Journal 146.1 (2013): 17. Zinn, R., et al. “La Silla QUEST RR Lyrae Star Survey: Region I.” arXiv preprint arXiv: 1312.1602 (2013). (accepted to ApJ) ( Link ) Rabinowitz, David, et al. “The La Silla–QUEST Kuiper Belt Survey.” The Astronomical Journal 144.5 (2012): 140. ( Link ) C. Baltay, et al. “The La Silla-QUEST Southern Hemisphere Variability Survey.” The European Southern Observatory Messenger (2012) ( Link ) Hadjiyska, Ellie, et al. “La Silla-QUEST Variability Survey in the Southern Hemisphere.” Proceedings of the International Astronomical Union 7.S285 (2011): 324-326. ( Link ) Rabinowitz, David, et al. “Discovery and Characterization of an Extremely Deep-Eclipsing Cataclysmic Variable: LSQ172554. 8-643839.” The Astrophysical Journal 732.1 (2011): 51." + }, + { + "name": "Benjamin Racine", + "profile_link": "https://physics.yale.edu/people/benjamin-racine", + "title": "Visiting Fellow", + "office": "benjamin.racine@yale.edu", + "email": "benjamin.racine@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5241-1733944371.png?itok=XUqSJV5Q", + "field_of_study": "Astrophysics & Cosmology", + "profile_bio": "I am an observational cosmologist, analysing data from several telescopes to understand the evolution of our Universe, from its origin to its current accelerated expansion. I worked for 10 years on the Cosmic Microwave Background (CMB). I studied the very early Universe mainly using two probes: - The measurement of the bispectrum of the temperature and polarisation data from the Planck satellite to study models beyond standard inflation [1,2] - The search for B-modes in the polarisation of the CMB, coming from primordial gravitational waves (PGW). We used data from Bicep/Keck, Planck and WMAP to put the strongest constraints to date on many models of inflation [3]. I was also involved in the design of the CMB-S4 experiment [4]. In 2020, I moved to the Marseille Particle Physics Center (CPPM) as a permanent CNRS researcher. I am now using type-1a Supernovae as distance indicators to probe the expansion and evolution of the Universe. I am working on the photometric calibration of the data from the Zwicky Transient Facility (ZTF) to provide the largest homogeneous low redshift sample of SN1a [5]. I am also a member of the LSST Dark Energy Science Collaboration (DESC), in particular interested in the detection of new transients in the images. Beyond the cosmic expansion, in my team in Marseille we are working on the use of distance indicators to probe the velocity fields in the nearby Universe. We can study the gravitational force through its effect on the growth rate of cosmic structures [6]. At Yale, I am interested in using DESI data to extend these studies. I am also interested in studying the imprint of velocity fields in the CMB data, for instance using Simons Observatory data.", + "website_text": null + }, + { + "name": "Anjana Rajkumar Kammath", + "profile_link": "https://physics.yale.edu/people/anjana-rajkumar-kammath", + "title": "Biol&Biomed Science Graduate Student", + "office": "YSB 138", + "email": "anjana.rajkumarkammath@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3847-1641220925.jpg?itok=3RZuNgT0", + "field_of_study": "Biological Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Peter Rakich", + "profile_link": "https://physics.yale.edu/people/peter-rakich", + "title": "Associate Professor of Applied Physics", + "office": "BCT 407", + "email": "peter.rakich@yale.edu", + "phones": [ + "203-432-9256" + ], + "website": "https://rakichlab.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-465-1383754204.jpg?itok=uCWw5I-s", + "field_of_study": "Condensed Matter PhysicsExperimentalistRadiation Pressure Induced Photon-Phonon Coupling at Nanoscales, Self-Adaptive Optomechanical Systems and Open-System Energetics, Novel Laser Sources Based on Photon-Phonon Interactions", + "profile_bio": "The Rakich group focuses on experimental nonlinear optics and spectroscopy. Research areas include: the study of natural and artificial forms of optical nonlinearity in nanostructured effective media; the dynamics and evolution of nonlinear systems at new time and length scales; optical forces and energetics in nanoscale systems; nonlinear nano-optomechanical interactions.", + "website_text": null + }, + { + "name": "Shasta Ramachandran", + "profile_link": "https://physics.yale.edu/people/shasta-ramachandran", + "title": "Graduate School Student", + "office": "SPL", + "email": "shasta.ramachandran@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3532-1753980789.png?itok=hW2ALr4G", + "field_of_study": "Nuclear PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Brandon Ramirez", + "profile_link": "https://physics.yale.edu/people/brandon-ramirez", + "title": "R&D Technician 3 - Mechanical Technician", + "office": "WLW", + "email": "brandon.ramirez@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4670-1693596990.jpg?itok=v1g8VKW8", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Rona Ramos", + "profile_link": "https://physics.yale.edu/people/rona-ramos", + "title": "Graduate Services Coordinator; Lecturer Physics", + "office": "SPL 35A", + "email": "rona.ramos@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-293-1547216671.jpg?itok=Jqe-cPaz", + "field_of_study": "Condensed Matter PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Rohit Raut", + "profile_link": "https://physics.yale.edu/people/rohit-raut", + "title": "Graduate School Student", + "office": "rohit.raut@yale.edu", + "email": "rohit.raut@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5392-1750086644.png?itok=6fq-6OCp", + "field_of_study": "Neutrinos and Dark Matter Searches, Experimental Particle Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Nicholas Read", + "profile_link": "https://physics.yale.edu/people/nicholas-read", + "title": "Henry Ford II Professor of Physics and Professor of Applied Physics and Mathematics", + "office": "SPL 55B", + "email": "nicholas.read@yale.edu", + "phones": [ + "+1 (203) 432-5042" + ], + "website": "http://cmtheory.sites.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-132-1379355960.jpg?itok=2rGkx398", + "field_of_study": "Condensed Matter Physics; Quantum PhysicsTheorist", + "profile_bio": null, + "website_text": "Condensed matter physics is the study of the macroscopic properties of materials. It seeks to use the well-established laws of microscopic physics to predict the collective properties of very large numbers of electrons, atoms or molecules. While the basic laws of motion of individual electrons, protons and neutrons are very simple, large numbers of such particles often display surprisingly complex phenomena. For materials as diverse as semiconductors, superconductors, or liquid crystals, considerable progress has been made in relating their bulk properties to those of their microscopic constituents. Much of the field relies on the principles of statistical mechanics, whose theoretical foundations were laid in the late 19th century by Yale physicist, Josiah Willard Gibbs (1839-1903). Another giant in the field is Yale Professor Lars Onsager (1903-1976), winner of the 1968 Nobel Prize . Theoretical research in condensed matter physics is carried out in an interdepartmental group of the Departments of Physics and Applied Physics. The group has ten faculty members, along with several postdoctoral fellows and graduate students. Interests range from the study of electronic properties of semiconductor microstructures to those of the high temperature superconductors, as well as from quantum optics and optomechanics to quantum information processing. Applications from students seeking a Ph.D. degree condensed matter theory are welcomed: Please contact the Yale Graduate School of Arts and Sciences . Other groups conducting theoretical research in related areas include  the group led by Yoram Alhassid on nuclear many body theory and quantum dots, research in Condensed Matter Geophysics led by John Wettlaufer, the Statistical Mechanics of Nonequilibrium Systems by Corey O’Hern in Mechanical Engineering. A tight collaboration is established with the experimental condensed matter groups in the Physics and Applied Physics Departments" + }, + { + "name": "Katie Ream", + "profile_link": "https://physics.yale.edu/people/katie-ream", + "title": "Graduate School Student", + "office": "katie.ream@yale.edu", + "email": "katie.ream@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5469-1751644465.jpg?itok=rn2SqucC", + "field_of_study": "", + "profile_bio": "Neutrinos and high energy experimental particle physics", + "website_text": null + }, + { + "name": "Alex Reda", + "profile_link": "https://physics.yale.edu/people/alex-reda", + "title": "Graduate School Student", + "office": "WLC 258", + "email": "alex.reda@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3342-1566585435.jpg?itok=0WWjJSsb", + "field_of_study": "Astrophysics/Cosmology", + "profile_bio": null, + "website_text": null + }, + { + "name": "Eric Regis", + "profile_link": "https://physics.yale.edu/people/eric-regis", + "title": "Graduate School Student", + "office": "eric.regis@yale.edu", + "email": "eric.regis@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4787-1693938860.png?itok=HblXAccd", + "field_of_study": "Biophysics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Glenn Richardson", + "profile_link": "https://physics.yale.edu/people/glenn-richardson", + "title": "Graduate School Student", + "office": "WL 230", + "email": "glenn.richardson@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3533-1754061803.jpg?itok=vZuRZkOH", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Cade Rodgers", + "profile_link": "https://physics.yale.edu/people/cade-rodgers", + "title": "Graduate School Student", + "office": "cade.rodgers@yale.edu", + "email": "cade.rodgers@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4788-1693939035.png?itok=hGd0UHq8", + "field_of_study": "Nuclear PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Andy Rodriguez", + "profile_link": "https://physics.yale.edu/people/andy-rodriguez", + "title": "Molecular Biophysics & Biochemistry Graduate School Student", + "office": "andrew.rodriguez@yale.edu", + "email": "andrew.rodriguez@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4533-1733944403.png?itok=HrDZl6d_", + "field_of_study": "BiophysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Gordon Rogelberg", + "profile_link": "https://physics.yale.edu/people/gordon-rogelberg", + "title": "Graduate School Student", + "office": "gordon.rogelberg@yale.edu", + "email": "gordon.rogelberg@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4161-1656335842.jpg?itok=BuOkyZdn", + "field_of_study": "Particle PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Josie Rose", + "profile_link": "https://physics.yale.edu/people/josie-rose", + "title": "Graduate School Student", + "office": "josie.rose@yale.edu", + "email": "josie.rose@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5470-1751373036.png?itok=cOlUZJtH", + "field_of_study": "", + "profile_bio": "I'm excited to start research in nuclear experiment/heavy ions. My previous work has been in stellar intensity interferometry, measuring the angular sizes and (for the first time!) shapes of bright stars.", + "website_text": null + }, + { + "name": "Kana Sakaguri", + "profile_link": "https://physics.yale.edu/people/kana-sakaguri", + "title": "Postdoctoral Fellow", + "office": "WLC-258A", + "email": "kana.sakaguri@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5479-1749648383.png?itok=hegAurIl", + "field_of_study": "Astrophysics & CosmologyExperimentalist21 cm cosmology, Canadian Hydrogen Intensity Mapping Experiment (CHIME)", + "profile_bio": "I work on 21 cm cosmology in Laura Newburgh’s group. I am a member of the Canadian Hydrogen Intensity Mapping Experiment (CHIME). My focus is on analyzing the visibility data while understanding the instruments for CHIME.", + "website_text": null + }, + { + "name": "Taylor Schaffner", + "profile_link": "https://physics.yale.edu/people/taylor-schaffner", + "title": "Graduate School Student", + "office": "taylor.schaffner@yale.edu", + "email": "taylor.schaffner@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3204-1753980659.jpg?itok=00crqc3X", + "field_of_study": "Biological Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Karina Schnee", + "profile_link": "https://physics.yale.edu/people/karina-schnee", + "title": "IT, Client Technologies Administrator 3", + "office": "SPL 65L", + "email": "karina.schnee@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5295-1738170242.png?itok=Svl0Voud", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Robert Schoelkopf", + "profile_link": "https://physics.yale.edu/people/robert-schoelkopf", + "title": "Sterling Professor of Applied Physics and Physics", + "office": "BCT 423", + "email": "robert.schoelkopf@yale.edu", + "phones": [ + "203-432-4289" + ], + "website": "http://rsl.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-135-1575477106.jpg?itok=DWzI9k8w", + "field_of_study": "Condensed Matter PhysicsExperimentalistThe development of solid-state quantum bits (qubits) for quantum computing, and the advancement of their performance to practical levels", + "profile_bio": "Schoelkopf focuses on quantum transport, single-electron devices, and charge dynamics in nanostructures. Broadly put, his research is concerned with quantum-effect and single-electron devices, both for fundamental physical studies and for applications. His techniques usually emphasize high-speed, high-sensitivity measurements performed on nanostructures at low temperatures. Our group has invented the Radio-Frequency Single-Electron Transistor (RF-SET), an electrometer capable of measuring sub-electron charges on nanosecond timescales, which places us in a unique position to study electrical transport at the single-charge level in a various systems. He is also developing new types of sensors and detectors which employ these capabilities. Current research projects include the development of quantum-limted amplifiers and electrometers. Here he wishes to study the intrinsic noise sources, measurement back-action effects, and the optimization and performance limits of SET electrometers. Another project is aimed at developing ultrasensitive detectors of sub-millimeter radiation, which could be capable of counting single photons. A third active area is the dynamics of single-Cooper pair devices, or superconducting quantum dots. In particular, he wishes to generate and manipulate coherent superpositions of charge states in these devices, and understand the decoherence of these macroscopic “qubits.” The goal is to evaluate the potential of this nanoelectronic system for performing solid-state quantum computation. In his work, he use several cryostats for low temperatures, including a dilution refrigerator capable of achieving about 5 mK, state-of-the-art microwave equipment for high-sensitivity measurements to frequencies of 40 GHz and beyond, a cleanroom with optical and electron-beam lithography, and systems for deposition of various metals.", + "website_text": null + }, + { + "name": "John Schotland", + "profile_link": "https://physics.yale.edu/people/john-schotland", + "title": "Zhao and Ji Professor of Mathematics", + "office": "DL 429", + "email": "john.schotland@yale.edu", + "phones": [ + "203-432-7055" + ], + "website": "https://gauss.math.yale.edu/~js4228", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3893-1631289784.jpg?itok=NH8mSV8U", + "field_of_study": "Condensed Matter Physics; Atomic, Molecular & Optical Physics; Quantum PhysicsTheoristThe study of problems at the interface of optical and condensed matter physics", + "profile_bio": "My research is in mathematical physics. In particular, I study problems at the interface of optical and condensed matter physics.\nI have a long-term interest in inverse problems with applications to imaging. My current work is focused on developing\nmathematical tools for many-body problems in quantum optics.", + "website_text": null + }, + { + "name": "Jurgen Schukraft", + "profile_link": "https://physics.yale.edu/people/jurgen-schukraft", + "title": "Professor Adjunct", + "office": "CERN", + "email": "jurgen.schukraft@yale.edu", + "phones": [], + "website": "http://star.physics.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3420-1738172050.jpg?itok=bNyfeWTO", + "field_of_study": "Relativistic Heavy IonsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Kirsty Scott", + "profile_link": "https://physics.yale.edu/people/kirsty-scott", + "title": "Graduate School Student", + "office": "WC Energy Sciences Ctr", + "email": "kirsty.scott@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3534-1733944432.png?itok=W8Tcu-9W", + "field_of_study": "Condensed Matter PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Ramamurti Shankar", + "profile_link": "https://physics.yale.edu/people/ramamurti-shankar", + "title": "J.W. Gibbs Professor of Physics", + "office": "SPL 55", + "email": "r.shankar@yale.edu", + "phones": [ + "+1 (203) 432-6917" + ], + "website": "https://campuspress.yale.edu/rshankar", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-136-1357318165.jpg?itok=K28sUGaK", + "field_of_study": "Condensed Matter PhysicsTheoristQuantum field theory", + "profile_bio": null, + "website_text": null + }, + { + "name": "Tal Sheffer", + "profile_link": "https://physics.yale.edu/people/tal-sheffer", + "title": "Graduate School Student", + "office": "BCT", + "email": "tal.sheffer@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4790-1693939233.png?itok=72iON2AD", + "field_of_study": "Quantum InformationExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Mengwen Shi", + "profile_link": "https://physics.yale.edu/people/mengwen-shi", + "title": "Graduate School Student", + "office": "YSB 132", + "email": "mengwen.shi@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3871-1630616096.png?itok=ttaxpzmD", + "field_of_study": "Biological Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Benjamin Siegel", + "profile_link": "https://physics.yale.edu/people/benjamin-siegel", + "title": "Graduate School Student", + "office": "WLW 322", + "email": "b.siegel@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3322-1566585778.jpg?itok=itRYIZlI", + "field_of_study": "Experimental Particle Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Maximiliano Silva-Feaver", + "profile_link": "https://physics.yale.edu/people/maximiliano-silva-feaver", + "title": "Mossman Fellow", + "office": "WLW", + "email": "maximiliano.silva-feaver@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4759-1706643361.jpg?itok=k62DoQ7V", + "field_of_study": "Astrophysics & Cosmology; Particle PhysicsExperimentalist", + "profile_bio": "I work in the fields of Cosmology and Dark Matter direct detection. I am a member of the Simons Observatory (SO) Cosmic Microwave Background (CMB) experiment, and the HAYSTAC and ALPHA Axion direct-detection experiments. For my PhD research, I designed, constructed, deployed, and tested the first SO Small Aperture Telescope (SAT). Within SO, I focused on camera readout electronics: the SLAC Microwave Radio Frequency (SMuRF) electronics , which were custom built to read out the superconducting microwave multiplexer cryogenic circuit capable of measuring ~1000 superconducting camera pixels on a single readout line. I led early testing and design iteration with the SLAC (DoE National Research Laboratory) team. I ultimately oversaw the system integration and operation at the SO high-elevation site in the Atacama Desert in Chile. I maintained the telescopes since their commissioning (Oct 2023). In 2022, I began working on the SO SAT data reduction and analysis pipeline utilizing simulation and North American lab data as a predoctoral research fellow at the Flatiron Institute. I continue this effort with the on-sky data as a Yale Mossman Fellow. I joined the HAYSTAC and ALPHA axion direct detection experiments at Yale. HAYSTAC is a microwave cavity haloscope that has set the tightest constraints on Axion-like dark matter in the 15-25 micro-electronvolt mass range operating since 2016. I am upgrading HAYSTAC to extend its sensitivity to a 30-35 micro-electronvolt mass range. ALPHA is a new experiment sited at Yale that will probe the 40-80 micro-electronvolt mass range using a new technique based on coupling the axion field to a tunable plasma resonance . I am designing and testing the ALPHA microwave receiver system and integrating the ALPHA haloscope at Yale.", + "website_text": null + }, + { + "name": "Sukhman Singh", + "profile_link": "https://physics.yale.edu/people/sukhman-singh", + "title": "Graduate School Student", + "office": "WLC-258", + "email": "sukhman.singh@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-2646-1754406224.jpg?itok=9FtgrdC1", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Shivnag Sista", + "profile_link": "https://physics.yale.edu/people/shivnag-sista", + "title": "Graduate School Student", + "office": "YQI", + "email": "shivnag.sista@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3535-1590606520.jpg?itok=uc7VAKLq", + "field_of_study": "Biological Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Elena Siuzdak", + "profile_link": "https://physics.yale.edu/people/elena-siuzdak", + "title": "Director, Finance and Administration", + "office": "SPL 31", + "email": "helen.siuzdak@yale.edu", + "phones": [ + "+1 (203) 494-8766" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4408-1669734009.jpg?itok=qkB0jp9R", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Sara Siwiecki", + "profile_link": "https://physics.yale.edu/people/sara-siwiecki", + "title": "Molecular Biophysics & Biochemistry Graduate Student", + "office": "YSB 142", + "email": "sara.siwiecki@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3849-1637161965.jpg?itok=APBhVSN5", + "field_of_study": "Biological Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Witold Skiba", + "profile_link": "https://physics.yale.edu/people/witold-skiba", + "title": "Professor of Physics", + "office": "SPL 53C", + "email": "witold.skiba@yale.edu", + "phones": [ + "+1 (203) 432-3903" + ], + "website": "http://het.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-137-1357318265.jpg?itok=b7hIEzWg", + "field_of_study": "Particle PhysicsTheorist", + "profile_bio": null, + "website_text": "Welcome Our group works on diverse topics in theoretical high energy physics, including physics beyond the Standard Model, field theory, quantum chromodynamics, conformal bootstrap, and early universe physics." + }, + { + "name": "Penny Slocum", + "profile_link": "https://physics.yale.edu/people/penny-slocum", + "title": "Research Scientist", + "office": "WL 204", + "email": "penny.slocum@yale.edu", + "phones": [ + "+1 (203) 432-3371" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-696-1549912308.png?itok=jrMcwC8O", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Nikolai Smirnov", + "profile_link": "https://physics.yale.edu/people/nikolai-smirnov", + "title": "Research Scientist", + "office": "Wright Lab-W 304", + "email": "nikolai.smirnov@yale.edu", + "phones": [ + "203-432-3006" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-167-1357329668.jpg?itok=slOvy52Q", + "field_of_study": "Nuclear PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Carlton Smith", + "profile_link": "https://physics.yale.edu/people/carlton-smith", + "title": "Graduate School Student", + "office": "YSB-C164", + "email": "carlton.smith@yale.edu", + "phones": [], + "website": null, + "image_url": 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"https://sous.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5516-1758551680.jpg?itok=Vkl6p0E1", + "field_of_study": "Condensed Matter Physics, Quantum Physics, Artificial Intelligence (AI)ExperimentalistQuantum MatterFractons from polaronsLight bipolarons stabilized by Peierls electron-electron couplingNon-equilibrium quantum dynamicsPhonon-induced disorder in dynamics of optically pumped metals from non-linear electron-phonon couplingArtificial Intelligence and physicsExtrapolating quantum observables with machine learning: Inferring multiple phase transitions from properties of a single phase", + "profile_bio": null, + "website_text": null + }, + { + "name": "Adriane Steinacker", + "profile_link": "https://physics.yale.edu/people/adriane-steinacker", + "title": "Senior Lecturer in Physics", + "office": "KT 421", + "email": "adriane.steinacker@yale.edu", + "phones": [], + "website": null, + "image_url": 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"https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3873-1630418086.jpg?itok=Ro9lAgCH", + "field_of_study": "Biological Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "A Douglas Stone", + "profile_link": "https://physics.yale.edu/people/douglas-stone", + "title": "Deputy Director, Yale Quantum Institute & Carl A. Morse Professor of Applied Physics and Physics", + "office": "YQI 436/437", + "email": "douglas.stone@yale.edu", + "phones": [ + "203-432-4279" + ], + "website": "http://www.eng.yale.edu/stonegroup/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-138-1575477161.jpg?itok=tPXYwhND", + "field_of_study": "Atomic, Molecular & Optical Physics; Quantum Physics; Condensed Matter PhysicsTheoristQuantum transport phenomena in disordered media, mesoscopic electron physics, non-linear and chaotic dynamics, quantum and wave chaos, quantum measurement and quantum computing. Laser physics, non-linear optics, microcavity and random lasers.", + "profile_bio": "Professor Stone’s current research is in optical physics and photonics, focusing on laser physics and microcavity optics, optical phenomena in complex and disordered systems, wave chaos and random matrix theory, non-hermitian effects and gain/loss engineering.  He also has an active interest in quantum measurement and quantum computing.  Trained as a condensed matter theorist, his earlier research was in the field of Anderson localization and quantum transport phenomena in disordered media, mesoscopic fluctuations of electronic conduction, non-linear dynamics, and quantum chaos. His major contributions to optical physics include the introduction of ray and wave chaos concepts for the description of deformed microcavities and lasers, the development of Steady-state Ab initio Laser Theory (SALT) for describing novel microlasers, including random and chaotic cavity lasers, the discovery of Coherent Perfect Absorption or time-reversed lasing, the discovery of long-range correlations in the scattering properties of disordered systems (all topics in collaboration with various colleagues). Professor Stone was one of the first condensed matter theorists to emphasize the novel properties of mesoscopic systems which are much larger than the atomic scale, but differ in their behavior from bulk solids. Prominent among these are phase coherence and related sample-specific fluctuations in all physical properties. Together with Patrick Lee he showed that the fluctuations of mesoscopic conductance are universal, with a variance depending only on the fundamental unit of conductance, e2/h, an effect which can be explained by the spectral rigidity of random matrices. Mesoscopic fluctuations have a direct connection to the field of quantum chaos which has applications in nuclear, atomic, condensed matter and optical physics, and Stone has applied concepts from quantum chaos theory to explain fluctuations in semiconductor quantum wires and quantum dots.", + "website_text": null + }, + { + "name": "Matthew Stortini", + "profile_link": "https://physics.yale.edu/people/matthew-stortini", + "title": "Graduate School Student", + "office": "Fermilab", + "email": "matthew.stortini@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3537-1592159002.png?itok=6GrLagYQ", + "field_of_study": "Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Qile Su", + "profile_link": "https://physics.yale.edu/people/qile-su", + "title": "Graduate School Student", + "office": "YQI 408", + "email": "q.su@yale.edu", + "phones": 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"website_text": null + }, + { + "name": "Noshin Tabassum", + "profile_link": "https://physics.yale.edu/people/noshin-tabassum", + "title": "Graduate School Student", + "office": "noshin.tabassum@yale.edu", + "email": "noshin.tabassum@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5472-1752688697.jpg?itok=b8l5FLYX", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Andrew Tamis", + "profile_link": "https://physics.yale.edu/people/andrew-tamis", + "title": "Graduate School Student", + "office": "WLW 309", + "email": "andrew.tamis@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3875-1630418180.jpg?itok=7UK6gV3U", + "field_of_study": "Nuclear PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Jingcheng Tan", + "profile_link": "https://physics.yale.edu/people/jingcheng-tan", + "title": "Graduate School Student", + "office": "jingcheng.tan@yale.edu", + "email": "jingcheng.tan@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4791-1748636229.jpg?itok=sSHaonOE", + "field_of_study": "Biophysics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Sanjana Taneja", + "profile_link": "https://physics.yale.edu/people/sanjana-taneja", + "title": "Graduate School Student", + "office": "sanjana.taneja@yale.edu", + "email": "sanjana.taneja@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4792-1693939555.png?itok=gbJ1BIzy", + "field_of_study": "Biophysics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Hong Tang", + "profile_link": "https://physics.yale.edu/people/hong-tang", + "title": "Llewellyn West Jones, Jr. Professor of Engineering", + "office": "BCT 525", + "email": "hong.tang@yale.edu", + "phones": [ + "+1 (203) 432-4256" + ], + "website": "http://www.eng.yale.edu/tanglab", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3688-1610035639.jpg?itok=9d9P7hCT", + "field_of_study": "Condensed Matter Physics; Quantum PhysicsExperimentalistQuantum transduction from microwave to optical photons,Quantum networks and quantum communications,Superconducting quantum detectors", + "profile_bio": "Nonlinear and quantum optics, Nano-electromechanical systems, Superconducting detector and circuits, Quantum transducers development.", + "website_text": null + }, + { + "name": "Gabriel Theilacker Assumpcao", + "profile_link": "https://physics.yale.edu/people/gabriel-theilacker-assumpcao", + "title": "Graduate School Student", + "office": "SPL 11", + "email": 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[], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-938-1696441213.jpg?itok=A7yHlmnf", + "field_of_study": "Astrophysics & CosmologyExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Jenny Tian", + "profile_link": "https://physics.yale.edu/people/jenny-tian", + "title": "Graduate School Student", + "office": "SPL 29", + "email": "jenny.tian@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3538-1588173396.jpg?itok=2WjHM1Wx", + "field_of_study": "Experimental Condensed Matter Physics", + "profile_bio": null, + "website_text": null + }, + { + "name": "Kimberly Tighe", + "profile_link": "https://physics.yale.edu/people/kimberly-tighe", + "title": "Senior Administrative Assistant", + "office": "WL 220", + "email": "kimberly.tighe@yale.edu", + "phones": [ + "203-436-8312" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-1096-1733944545.png?itok=rDjXoeM3", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Paul L. Tipton", + "profile_link": "https://physics.yale.edu/people/paul-l-tipton", + "title": "Eugene Higgins Professor of Physics", + "office": "KT 419 / WL 235", + "email": "paul.tipton@yale.edu", + "phones": [ + "203-436-8501" + ], + "website": "https://hep.yale.edu/people/faculty/paul-l-tipton/research", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-140-1737561984.jpg?itok=SaQ-04E0", + "field_of_study": "Particle PhysicsExperimentalistATLAS;Selected Presentations and Articles for a General Audience", + "profile_bio": null, + "website_text": "Our group is conducting research as part of the ATLAS experiment which collects data from proton-proton collisions at the LHC located at CERN in Geneva Switzerland.  We have two main areas of research. First, in collaboration with Prof. Sarah Demers’ group, we are taking the lead in a measurement of the quantum numbers of the newly discovered Higgs boson .  By studying the decay angular correlations of the Higgs decay to pairs of tau leptons, we will be sensitive to the charge conjugation and parity properties of the Higgs coupling to the tau.  This work will be an extension of a previous ATLAS publication , for which we hope to use our expertise in deep neural networks to gain sensitivity. Secondly, in Yale’s Wright Lab we are helping to construct an upgrade to the ATLAS particle tracking system.   Planned upgrades to the LHC accelerator will open exciting new physics opportunities.  These upgrades will necessitate more collisions per beam crossing, which will require a new ATLAS tracker that is more radiation hard and has better spatial resolution. In clean room facilities at Wright Lab, we are fabricating the support structures call stave cores.   Each stave core will have 28 thin silicon-wafer strip particle detectors mounted on it.  Staves will reside in the central (barrel) region of the new tracker.  Stave cores are fabricated with advanced composite materials such as carbon foam.  We are using robotic technology and thermal imaging for tests of parts and completed stave cores. Previously our group conducted a number of research projects on ATLAS, including numerous results using the H->gamma gamma decay mode.  We conducted the first search for di-Higgs and made important contributions to subsequent searches, and we led the intitial effort to observe the Higgs being produced with top-quark pairs.  We worked with two other groups to set new limits on first and second-generation leptoquark production.  Next we performed a broad search for new exotic phenomenon that would give rise to events with three or more high energy leptons .   Our first analysi effort  on ATLAS helped establish that ATLAS was physics-ready.  We  made important contributions to the group effort that made the first measurement of the top cross section using the ATLAS detector. Before joining ATLAS, our group had a successful program at Fermilab as part of the CDF Collaboration . Our group made essential contributions to the discovery of the top quark and made subsequent measurements of its mass .  We searched for new objects that would decay into pairs of top quarks, and a searched for rare flavor-changing neutral current decays of the top.  We also performed a test for new physics in the kinematics of top decay products and a search for a charged Higgs in top decays .  The culmination of our program at CDF included the first evidence for photons produced with top quarks and the strongest evidence from the Tevatron for the Higgs boson that was subsequently discovered at the LHC. Return to Paul Tipton’s Homepage" + }, + { + "name": "Yarone Tokayer", + "profile_link": "https://physics.yale.edu/people/yarone-tokayer", + "title": "Graduate School Student", + "office": "KT", + "email": "yarone.tokayer@yale.edu", + "phones": [], + "website": "https://yaronetokayer.github.io/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3876-1630418223.jpg?itok=63e0dqtm", + "field_of_study": "Astrophysics/Cosmology", + "profile_bio": null, + "website_text": null + }, + { + "name": "Matthew Toledo Rozycki", + "profile_link": "https://physics.yale.edu/people/matthew-toledo-rozycki", + "title": "Graduate School Student", + "office": "matthew.toledorozycki@yale.edu", + "email": "matthew.toledorozycki@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3921-1733944577.png?itok=SiCxBQ0l", + "field_of_study": "", + "profile_bio": null, + "website_text": null + }, + { + "name": "Yu-Han Tseng", + "profile_link": "https://physics.yale.edu/people/yu-han-tseng", + "title": "Graduate School Student", + "office": "WLW 322", + "email": "yuhan.tseng@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3877-1655213466.jpg?itok=HqxHbRWY", + "field_of_study": "Nuclear PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Alan Tsidilkovski", + "profile_link": "https://physics.yale.edu/people/alan-tsidilkovski", + "title": "Graduate School Student", + "office": "alan.tsidilkovski@yale.edu", + "email": "alan.tsidilkovski@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4710-1733944607.png?itok=IZiOtA2x", + "field_of_study": "Atomic, Molecular, and Optical PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Navya Uberoi", + "profile_link": "https://physics.yale.edu/people/navya-uberoi", + "title": "Graduate School Student", + "office": "KT 463", + "email": "navya.uberoi@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4174-1657030415.jpg?itok=XeuNloFl", + "field_of_study": "Astrophysics & Cosmology", + "profile_bio": null, + "website_text": null + }, + { + "name": "Thomas Ullrich", + "profile_link": "https://physics.yale.edu/people/thomas-ullrich", + "title": "Professor (Adjunct) of Physics", + "office": "WLW-308 / Brookhaven National Lab", + "email": "thomas.ullrich@yale.edu", + "phones": [ + "+1 (203) 432-5829" + ], + "website": "http://rhig.physics.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-592-1738172278.jpg?itok=C-EJihDG", + "field_of_study": "Relativistic Heavy Ions", + "profile_bio": null, + "website_text": null + }, + { + "name": "Naveen Umasankar", + "profile_link": "https://physics.yale.edu/people/naveen-umasankar", + "title": "Graduate School Student", + "office": "naveen.umasankar@yale.edu", + "email": "naveen.umasankar@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4715-1693939904.png?itok=6mNlktGX", + "field_of_study": "Particle PhysicsTheorist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Meg Urry", + "profile_link": "https://physics.yale.edu/people/meg-urry", + "title": "Israel Munson Professor of Physics", + "office": "KT 533", + "email": "meg.urry@yale.edu", + "phones": [ + "+1 (203) 432-5997" + ], + "website": "http://urrylab.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-142-1737561959.jpg?itok=pPw-OuTt", + "field_of_study": "Astrophysics & CosmologyTheorist & ExperimentalistHidden Supermassive Black Holes, AGN host galaxies, Unification of AGN, Supermassive Black Holes in AGN and the “Grand Unification” Hypothesis, Blazars, Kiloparsec-scale jets", + "profile_bio": "Prof. Urry’s scientific research focuses on active galaxies, which host accreting supermassive black holes in their centers. Her group uses telescopes in space and on the ground, to conduct multi-wavelength surveys, measure line widths from which black hole masses can be derived, and analyze the dominant radiation components. To interpret these data, Urry and her collaborators develop models for the evolution of black hole growth over cosmic time. In recent years, the group has developed machine learning techniques to study galaxy properties and to characterize spectral energy distributions. 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School Student", + "office": "SPL 13", + "email": "raffaella.zanetti@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4794-1693940022.png?itok=CRTDHj_F", + "field_of_study": "AMOExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Michael Zeller", + "profile_link": "https://physics.yale.edu/people/michael-zeller", + "title": "Professor Emeritus of Physics", + "office": "EVN 111", + "email": "michael.zeller@yale.edu", + "phones": [ + "+1 (203) 432-3372" + ], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-71-1356111667.jpg?itok=XoptPw61", + "field_of_study": "Elementary Particle PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Yijun Zhang", + "profile_link": "https://physics.yale.edu/people/yijun-zhang", + "title": "Graduate School Student", + "office": "yijun.zhang@yale.edu", + "email": "yijun.zhang@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5111-1722263602.png?itok=TRX4APDC", + "field_of_study": "Atomic, Molecular, and Optical PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Ziyi Zhao", + "profile_link": "https://physics.yale.edu/people/ziyi-zhao", + "title": "Visiting Associate in Research", + "office": "YSB C188", + "email": "zz544@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5328-1738183036.png?itok=fg4ZzgQJ", + "field_of_study": "Condensed Matter PhysicsExperimentalist", + "profile_bio": null, + "website_text": null + }, + { + "name": "Qinyuan Zheng", + "profile_link": "https://physics.yale.edu/people/qinyuan-zheng", + "title": "Graduate School Student", + "office": "qinyuan.zheng@yale.edu", + "email": "qinyuan.zheng@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4172-1656593413.jpg?itok=GZqjrhGf", + "field_of_study": "Astrophysics & Cosmology", + "profile_bio": null, + "website_text": null + }, + { + "name": "Peter Zhou", + "profile_link": "https://physics.yale.edu/people/peter-zhou", + "title": "Graduate School Student", + "office": "SPL 11", + "email": "p.zhou@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3326-1733944805.png?itok=rJQCYF64", + "field_of_study": "Atomic & Optical Physics", + "profile_bio": null, + "website_text": null + } +] \ No newline at end of file diff --git a/web-scraper/History_WebScraper.py b/web-scraper/History_WebScraper.py new file mode 100644 index 0000000..d312520 --- /dev/null +++ b/web-scraper/History_WebScraper.py @@ -0,0 +1,147 @@ +import requests +from bs4 import BeautifulSoup +import time +import json +from urllib.parse import urljoin + +BASE_URL = "https://history.yale.edu" +FACULTY_URL = "https://history.yale.edu/people/faculty" + +HEADERS = { + "User-Agent": ( + "Mozilla/5.0 (Macintosh; Intel Mac OS X 10_15_7) " + "AppleWebKit/537.36 (KHTML, like Gecko) " + "Chrome/118.0.0.0 Safari/537.36" + ) +} + +# Fetch HTML & parse +def get_soup(url): + try: + r = requests.get(url, headers=HEADERS, timeout=15) + r.raise_for_status() + return BeautifulSoup(r.text, "html.parser") + except Exception as e: + print(f"Error fetching {url}: {e}") + return None + +def get_faculty_list(): + faculty = [] + page = 0 + + while True: + url = f"{FACULTY_URL}?page={page}" + print("Loading list page:", url) + + soup = get_soup(url) + if not soup: + break + + rows = soup.select("table.views-table tbody tr") + if not rows: + break # No more pages + + for row in rows: + # Name + profile URL + name_link = row.select_one("td.views-field-name a") + if not name_link: + continue + + name = name_link.get_text(strip=True) + profile_url = urljoin(BASE_URL, name_link["href"]) + + # Fields of interest + interest_cell = row.select_one( + "td.views-field-field-field-s-of-interest" + ) + fields_of_interest = ( + interest_cell.get_text(" ", strip=True) + if interest_cell + else None + ) + + faculty.append({ + "name": name, + "profile_url": profile_url, + "fields_of_interest": fields_of_interest + }) + + page += 1 + time.sleep(0.5) + + return faculty + +# Extract full bio +def extract_full_bio(profile_url): + soup = get_soup(profile_url) + if not soup: + return None + + # Find the bio section - it's in a div with a label "Bio:" + bio_parts = [] + + # Look for all field items in the main content area + # The bio appears after the "Bio:" label in the field content + labels = soup.find_all("div", class_="field-label") + + for label in labels: + if label.get_text(strip=True) == "Bio:": + # Get the next sibling which should be the field-items div + field_items = label.find_next_sibling("div", class_="field-items") + if field_items: + # Extract all text, preserving paragraph breaks + paragraphs = field_items.find_all("p") + if paragraphs: + for p in paragraphs: + text = p.get_text(strip=True) + if text: + bio_parts.append(text) + else: + # If no paragraphs, just get all text + text = field_items.get_text(strip=True) + if text: + bio_parts.append(text) + break + + # Also check for publications and awards if present + publications = [] + for label in soup.find_all("strong"): + if "Publications" in label.get_text(): + parent = label.find_parent() + if parent: + items = parent.find_all("li") + for item in items: + publications.append(item.get_text(strip=True)) + + # Join bio parts + bio_text = "\n\n".join(bio_parts) if bio_parts else None + + return bio_text +# Scrape all faculty +def scrape_all(): + faculty = get_faculty_list() + print(f"Found {len(faculty)} faculty") + + results = [] + + for i, person in enumerate(faculty, 1): + print(f"[{i}/{len(faculty)}] Scraping {person['name']}") + bio = extract_full_bio(person["profile_url"]) + + results.append({ + "name": person["name"], + "department": "History", + "profile_url": person["profile_url"], + "fields_of_interest": person["fields_of_interest"], + "bio": bio + }) + + time.sleep(0.5) # polite scraping + + with open("yale_history_faculty.json", "w", encoding="utf-8") as f: + json.dump(results, f, indent=2, ensure_ascii=False) + + print(f"Saved yale_history_faculty.json with {len(results)} faculty members") + +if __name__ == "__main__": + scrape_all() \ No newline at end of file diff --git a/web-scraper/Web_Scraper.py b/web-scraper/Web_Scraper.py new file mode 100644 index 0000000..1b73246 --- /dev/null +++ b/web-scraper/Web_Scraper.py @@ -0,0 +1,78 @@ +""" +Scrapes the yale directory website in order to find information about all listed professors +Eventually will create default RDB listings for all professors on the directory website +""" + +import requests +import time +from selenium import webdriver +from bs4 import BeautifulSoup +from string import ascii_lowercase + +BASE_URL = "https://physics.yale.edu/people" + +driver = webdriver.Chrome() + +def getURL(lastName): + return BASE_URL + lastName + +def getSite(lastName, maxSearchDuration = 3): + driver.get(getURL(lastName)) + searchDuration = 0 + while(((getSoup(driver.page_source).find(id = 'loading-indicator') == None) | ('inline' in getSoup(driver.page_source).find(id = 'loading-indicator')['style'])) & (searchDuration < maxSearchDuration)): + time.sleep(0.1) + searchDuration += 0.1 + return driver.page_source + +def getSoup(site): + return BeautifulSoup(site, 'html.parser') + +def addListings(listings, nameStr = '', startChar = 'a', endChar = 'c', display = False): + for c in ascii_lowercase[ascii_lowercase.index(startChar):(ascii_lowercase.index(endChar) + 1)]: + soup = getSoup(getSite(nameStr + c)) + + resultsText = soup.find(id = 'results-people-header').text + + numResults = int(resultsText.split(' ')[0]) if resultsText.split(' ')[0].isdigit() else 1 if 'display: none' in soup.find(id = 'bps-result-region')['style'].split(';') else 0 + + if(display): + if(numResults == 25): + print(f'Searching "{nameStr + c}"... Found {numResults} results') + + surplusResults = numResults != 1 and 'display: block' in soup.find(id = 'bps-result-region').find('div', class_ = 'directory_results_warning')['style'].split(';') + + #Handle surplus results + if(surplusResults): + addListings(listings = listings, nameStr = nameStr + c) + else: + listings.extend(soup.find_all("article", class_ = "directory_item")[0:numResults]) + +def getListings(startChar = 'a', endChar = 'z', display = False): + listings = [] + addListings(listings = listings, startChar = startChar, endChar = endChar, display = display) + return listings + +import csv + +def saveListingsToCSV(listings, filename='listings.csv'): + with open(filename, mode='w', newline='', encoding='utf-8') as file: + writer = csv.writer(file) + writer.writerow(['Listing Name']) # Header row + for listing in listings: + writer.writerow([listing]) + + +# Collect listings +myListings = [] +addListings(myListings) + +# Save to CSV +saveListingsToCSV(myListings) + +# Output the total number of listings found +print(f'Total listings found: {len(myListings)}') + +# Close the Selenium driver +driver.quit() + +#5620 diff --git a/web-scraper/testscrape.py b/web-scraper/testscrape.py new file mode 100644 index 0000000..df021a2 --- /dev/null +++ b/web-scraper/testscrape.py @@ -0,0 +1,121 @@ +import requests +from bs4 import BeautifulSoup +import time +import json + +url = "https://physics.yale.edu/people" +response = requests.get(url) +soup = BeautifulSoup(response.text, "html.parser") + +faculty_data = [] +count = 0 + +# Loop through each table row containing a listing +for row in soup.find_all("tr"): + name_cell = row.find("td", class_="views-field-name") + if not name_cell: + continue # Skip rows without a listing + + # --- Name & profile link --- + name_tag = name_cell.find("a", class_="username") + name = name_tag.get_text(strip=True) if name_tag else None + profile_link = f"https://physics.yale.edu{name_tag['href']}" if name_tag else None + + # --- Text content --- + text_parts = list(name_cell.stripped_strings) + # First entry is name + title = text_parts[1] if len(text_parts) > 1 else None + office = text_parts[2] if len(text_parts) > 2 else None + + # --- Email --- + email_tag = name_cell.find("a", href=lambda x: x and x.startswith("mailto:")) + email = email_tag.get_text(strip=True) if email_tag else None + + # --- Website --- + website_tag = name_cell.find("a", href=lambda x: x and x.startswith("http")) + website = website_tag['href'] if website_tag else None + + # --- Phone numbers --- + phones = [] + for t in text_parts: + # Match typical phone patterns + if "Phone:" in t or t.replace("-", "").strip().isdigit(): + phones.append(t.replace("Phone:", "").strip()) + + # --- Picture --- + pic_cell = row.find("td", class_="views-field-picture") + img_tag = pic_cell.find("img") if pic_cell else None + image_url = img_tag['src'] if img_tag else None + + # --- Field of study --- + study_cell = row.find("td", class_="views-field-field-field-of-study") + field_of_study = study_cell.get_text(strip=True) if study_cell else None + + count += 1 + + # --- Scrape profile page for bio text --- + profile_bio = None + if profile_link: + try: + print(f"Scraping profile page {count}: {name} - {profile_link}...") + profile_response = requests.get(profile_link, timeout=10) + profile_soup = BeautifulSoup(profile_response.text, "html.parser") + + # Look for the research narrative field + research_field = profile_soup.find("div", class_="field-name-field-research-narrative") + if research_field: + field_item = research_field.find("div", class_="field-item even") + if field_item: + profile_bio = field_item.get_text(separator=" ", strip=True) + + time.sleep(0.5) + except Exception as e: + print(f"Error scraping profile page {profile_link}: {e}") + profile_bio = None + + # --- Scrape external website for research/bio text --- + website_text = None + if website: + try: + print(f"Scraping website {count}: {name} - {website}...") + website_response = requests.get(website, timeout=10) + website_soup = BeautifulSoup(website_response.text, "html.parser") + + # Extract text from the specific div with class "field-item even" + field_item = website_soup.find("div", class_="field-item even") + if field_item: + website_text = field_item.get_text(separator=" ", strip=True) + else: + # Fallback: try just "field-item" or "field-items" + field_item = website_soup.find("div", class_="field-item") + if field_item: + website_text = field_item.get_text(separator=" ", strip=True) + + # Optional: be respectful with rate limiting + time.sleep(0.5) + except Exception as e: + print(f"Error scraping {website}: {e}") + website_text = None + else: + print(f"No website found for {name}") + + faculty_data.append({ + "name": name, + "profile_link": profile_link, + "title": title, + "office": office, + "email": email, + "phones": phones, + "website": website, + "image_url": image_url, + "field_of_study": field_of_study, + "profile_bio": profile_bio, + "website_text": website_text + }) + +# Save to JSON file +with open("faculty_data.json", "w", encoding="utf-8") as json_file: + json.dump(faculty_data, json_file, indent=2, ensure_ascii=False) + +print(f"\nData saved to faculty_data.json") +print(f"Total faculty members scraped: {len(faculty_data)}") \ No newline at end of file diff --git a/web-scraper/webscraper_MED.py b/web-scraper/webscraper_MED.py new file mode 100644 index 0000000..670fd2a --- /dev/null +++ b/web-scraper/webscraper_MED.py @@ -0,0 +1,161 @@ +import requests +from bs4 import BeautifulSoup +import time +import json + +BASE_URL = "https://medicine.yale.edu" +URL = "https://medicine.yale.edu/about/a-to-z-index/atoz/lab-websites/" + +headers = { + "User-Agent": "Mozilla/5.0 (Macintosh; Intel Mac OS X 10_15_7) " + "AppleWebKit/537.36 (KHTML, like Gecko) " + "Chrome/118.0.0.0 Safari/537.36", + "Accept-Language": "en-US,en;q=0.9", +} + +def get_soup(url): + try: + response = requests.get(url, headers=headers, timeout=10) + response.raise_for_status() + return BeautifulSoup(response.text, "html.parser") + except Exception as e: + print(f"Error fetching {url}: {e}") + return None + +print("Scraping Yale Medicine Lab Directory...") +soup = get_soup(URL) +if soup is None: + raise RuntimeError("Failed to load A–Z page") + +lab_links = [] + +# --- STEP 1: Extract lab links from table rows --- +# The A-to-Z page has a table with two columns: Lab Name | URL +table = soup.find("table") +if not table: + print("Warning: no found on the A–Z page. Inspecting HTML…") +else: + for row in table.find_all("tr"): + cols = row.find_all("td") + # Expect two columns: name and link + if len(cols) >= 2: + name = cols[0].get_text(strip=True) + link_tag = cols[1].find("a", href=True) + if link_tag: + href = link_tag["href"] + # Fix relative path + if href.startswith("/"): + href = BASE_URL + href + lab_links.append({ + "lab_name": name, + "url": href + }) + +print(f"Found {len(lab_links)} labs.") + +def find_publications_page(lab_url): + soup = get_soup(lab_url) + if not soup: + return None + + # look for nav links + nav_links = soup.find_all("a", href=True) + + pub_keywords = ["publication", "publications", "papers", "selected", "articles"] + + for a in nav_links: + text = a.get_text(strip=True).lower() + href = a["href"] + + if any(k in text for k in pub_keywords): + # fix relative URL + if href.startswith("/"): + return BASE_URL + href + elif href.startswith("http"): + return href + else: + # relative to current lab site + return lab_url.rstrip("/") + "/" + href + + return None + + +def scrape_publications(pub_url): + if not pub_url: + return None + + soup = get_soup(pub_url) + if not soup: + return None + + # Try extracting lists (common format) + list_items = soup.find_all("li") + if list_items: + pubs = [li.get_text(separator=" ", strip=True) for li in list_items] + if pubs: + return pubs + + # fallback: paragraph blocks + ps = soup.find_all("p") + if ps: + pubs = [p.get_text(separator=" ", strip=True) for p in ps] + if pubs: + return pubs + + # fallback: general text + text = soup.get_text(separator=" ", strip=True) + return text[:5000] # safety cut-off + + +# --- STEP 2: Scrape each lab for research bio --- +def extract_lab_bio(lab_url): + soup = get_soup(lab_url) + if not soup: + return None + + # potential containers for research narrative + selectors = [ + ("div", "wysiwyg"), + ("div", "field-item"), + ("div", "field-item even"), + ("section", "research"), + ] + for tag, cls in selectors: + el = soup.find(tag, class_=cls) + if el: + return el.get_text(separator=" ", strip=True) + + # fallback: join big paragraphs + ps = soup.find_all("p") + if len(ps) >= 3: + return " ".join(p.get_text(strip=True) for p in ps) + + return None + +output = [] +for i, lab in enumerate(lab_links, start=1): + print(f"Scraping lab {i}/{len(lab_links)}: {lab['lab_name']} — {lab['url']}") + + # research page scrape + bio = extract_lab_bio(lab["url"]) + + # publications page scrape + pub_page = find_publications_page(lab["url"]) + publications = scrape_publications(pub_page) + + output.append({ + "lab_name": lab["lab_name"], + "lab_url": lab["url"], + "research_bio": bio, + "publications_page": pub_page, + "publications": publications + }) + + time.sleep(0.5) + + +# --- Save to JSON --- +with open("yale_medicine_labs.json", "w", encoding="utf-8") as f: + json.dump(output, f, indent=2, ensure_ascii=False) + +print("Saved yale_medicine_labs.json") diff --git a/yale_history_faculty.json b/yale_history_faculty.json new file mode 100644 index 0000000..ce4d12c --- /dev/null +++ b/yale_history_faculty.json @@ -0,0 +1,436 @@ +[ + { + "name": "Alvita Akiboh", + "department": "History", + "profile_url": "https://history.yale.edu/people/alvita-akiboh", + "fields_of_interest": "United States; U.S. imperialism; Caribbean; Pacific; material culture; nations and national identity", + "bio": "Alvita Akiboh (pronunciation) is a US historian specializing in the history of US overseas colonies in the Caribbean and Pacific. She earned her PhD in History from Northwestern University and BA in History from Indiana University. Before coming to Yale, Akiboh was a postdoctoral fellow in the Michigan Society of Fellows.Akiboh’s first bookImperial Material: National Symbols in the US Colonial Empire(University of Chicago Press, 2023) tells the story of how objects laden with US national symbols—flags, money, and postage stamps—became an arena in which contests over national identity played out in the US colonial empire from the turn of the twentieth century to the post-WWII era of global decolonization. In these overseas colonies occupying the tenuous space between foreign and domestic, these seemingly mundane objects became central for both US imperialists who sought to establish and maintain US colonial rule and for people living in the colonies who made claims to belonging, resisted US rule, and used these symbolic objects to articulate their own understanding of their relationship to the United States.Imperial Materialwon the Myrna F. Bernath Book Award from the Society for Historians of American Foreign Relations (SHAFR). Advance praise describes it as a “vividly written,” “original and compelling,” “ambitious and deeply researched work of scholarship” that “covers uncharted territory in the historiography of American empire and empire more broadly.” You can listen to Akiboh speak aboutImperial Materialon theNew Books Networkpodcast.Akiboh has conducted research throughout the continental United States and the overseas territories, including American Samoa, Guam, Hawai‘i, the Philippines, Puerto Rico, and the US Virgin Islands. She has published inDiplomatic HistoryandModern American History.Her work has been supported by a variety of organizations, including the American Historical Association, the Society for Historians of American Foreign Relations, and the Smithsonian National Postal Museum and National Museum of American History.At Yale, Akiboh teaches courses on US history, national identity, colonialism, and empire. Please checkcourses.yale.edufor current offerings.PublicationsImperial Material: National Symbols in the US Colonial Empire(University of Chicago Press, 2023)“Empire’s Embezzlers: Fraud and Scandal in US-Occupied Cuba, 1900-1902,”Modern American History6, no. 3 (Nov. 2023): 301-321.“Pocket-Sized Imperialism: U.S. Designs on Colonial Currency,”Diplomatic History41 (Nov. 2017): 874-902.Selected AwardsMyrna F. Bernath Book Award (2024)Harold Perkin Prize for Best Dissertation (2019)Weinberg College of Arts & Sciences Outstanding Graduate Teaching Award (2018)" + }, + { + "name": "Jennifer Allen", + "department": "History", + "profile_url": "https://history.yale.edu/people/jennifer-allen", + "fields_of_interest": "Modern German history; cultural history of modern Europe; theories and practices of memory; grassroots activism; the politics of space; Europe after the Cold War", + "bio": "Jennifer Allen is a historian of modern Germany with a particular interest in late twentieth-century cultural practices. Her first book,Sustainable Utopias: The Art and Politics of Hope in Germany(Harvard University Press, forthcoming) charts the history of Germany’s relatively recent efforts to revitalize the concept of utopia after the wholesale collapse of Europe’s violent utopian social engineering projects by the end of the twentieth century. She argues that, contrary to popular accounts, German interest in radical alternatives to existing society had not diminished. By braiding together case studies from three different milieux—the Berlin History Workshop, the German Green Party, and a loose collection of artists of public space—Allen demonstrates that Germans chose to resist an increasing sense of political disenfranchisement, social alienation, and cultural impotence in the 1980s and ’90s. Instead, they pursued the radical democratization of politics and culture in everyday life through a series of grassroots cultural projects. These groups not only envisioned a new German utopia but attempted to enact their vision. In doing so, they reclaimed utopian hope from the dustbin of historical ideas. In a related article (https://www.journals.uchicago.edu/doi/full/10.1086/701580), Allen traces how Germany’s grassroots commemorative practices became a model for international communities as diverse as Moscow, Buenos Aires, and Washington D.C., over the past thirty years.Allen’s second book project,Insurance Against Total Destruction: A Postwar History of German Plans to Save the World, analyzes postwar German efforts to archive the raw materials needed to rebuild national and international cultures after total catastrophe. As the Cold War intensified, both sides of the Iron Curtain sought new ways to protect themselves against a possible hot war. Europe’s leadership recognized its relative powerlessness against the destructive capacity of nuclear weapons. Their pessimism about the future led them to plan seriously for the possibility of absolute destruction and its aftermath. But what might that disaster look like? And how could the world actually be pulled back from the brink of annihilation – not only atomic destruction but also climate catastrophe, even Malthusian collapse? As the frontline of Cold War antagonism, Germans – both East and West – were particularly motivated to engage these questions. To examine the range of answers Germans offered, Allen’s project brings together an unlikely pairing of postwar narratives: the history of West German efforts to preserve German cultural heritage and the history of East German efforts to preserve biodiversity through gene banking. This analysis starts in Germany but travels around the world to places like Ethiopia, Costa Rica, and the islands of the Arctic Circle. These blueprints for rebuilding whole cultures from scratch give us insight into the shifting values of European institutions of cultural power during and after the Cold War. Allen’s work brings together scholarship on future studies, environmentalism, decolonization and the relationship of the developed world to the Global South, and the cultural implications of actuarial science to examine how both sides of Cold War fought to preserve their self-conception as protectors of civilization.Allen received her B.A. (2006) in political and social thought from the University of Virginia and her M.A. (2010) and Ph.D. (2015) in history from the University of California, Berkeley. Her work has been funded by the German Academic Exchange Service, the Volkswagen and Mellon Foundations, the Institute for Contemporary History in Munich, the American Academy in Berlin, and Yale’s MacMillan Center and Whitney Humanities Center. At Yale, Allen teaches undergraduate and graduate courses on modern German history, twentieth-century European history, the theories and practices of modern memory, counterculture and grassroots activism, and the history of the Holocaust." + }, + { + "name": "Sunil Amrith", + "department": "History", + "profile_url": "https://history.yale.edu/people/sunil-amrith", + "fields_of_interest": "Modern South Asian, Southeast Asian and Indian Ocean history; the history of migration and diasporas; environmental history, especially the history of water and climate; the history of port cities", + "bio": "Sunil Amrith is the Renu and Anand Dhawan Professor of History at Yale University, with a secondary appointment as Professor at the Yale School of the Environment. He is the Henry R. Luce Director of the Whitney and BettyMacMillan Centerfor International and Area Studies, Yale’s hub for international research, and also serves as Yale’sVice Provostfor International Affairs.In his role as vice provost, Professor Amrith advises university leaders on global matters and has oversight of international offices and programs, including the Office of International Affairs, the Office of International Students and Scholars, the President’s Council on International Activities, and several other programs.Amrith’s research focuses on the movements of people and the ecological processes that have connected South and Southeast Asia, and has expanded to encompass global environmental history. He has published in the fields of environmental history, the history of migration, and the history of public health.Amrith is the recipient of the 2025 Toynbee Prize in Global History, the 2024Fukuoka Academic Prize, awarded to recognize contributions to the study of Asian cultures, the 2022 Dr.A.H. Heineken Prizefor History, a “scientific breakthrough of the year” award from the Falling Walls Foundation in 2022, a 2017MacArthur Fellowship, and the 2016Infosys Prizein Humanities. In 2024, Amrith was elected an International Fellow of the British Academy.Amrith’s new book isThe Burning Earth, an environmental history of the modern world that foregrounds the experiences of the Global South (W.W. NortonandPenguin UK), it was named a 2024 “essential read” byThe New Yorker, a “book we love” 2024 byNPR, and was a finalist for the 2025 PEN/E.O. Wilson prize. It is being translated into ten languages.Amrith’s four previous books includeUnruly Waters(Basic BooksandPenguin UK)—shortlisted for the 2019 Cundill Prize, and reviewed inNature,The Economist,The Wall Street JournalandThe New York Review of Books—andCrossing the Bay of Bengal: The Furies of Nature and the Fortunes of Migrants(Harvard University Press, 2013), which was awarded the American Historical Association’s John F. Richards Prize in 2014, and selected as an Editor’s Choice title by theNew York Times Book Review. Amrith serves on the editorial board ofModern Asian Studiesand the advisory board ofCapitalism: A Journal of History and Economics, and he is one of the series editors of the Princeton University Press book series,Histories of Economic Life.In current work, Amrith continues to study the relationship between migration and environmental change. Professor Amrith delivered the Radhakrishnan Lectures at All Souls College, Oxford in May 2025, on the topic of “The Developmental State in Climate Crisis.” He will give the Wiles Lectures at Queen’s University Belfast in May 2026 on the theme of Repair, which will be the subject of his next book.Professor Amrith welcomes inquiries from prospective graduate students interested in working on any aspect of modern South and Southeast Asian history, as well as on topics in global environmental history.Before coming to Yale, Amrith was the inaugural Mehra Family Professor of South Asian Studies at Harvard University from 2015-20, where he also served as co-director of the Joint Center for History and Economics, and Interim Director of the Mahindra Humanities Center (in 2019-20). From 2006-2015, he taught at Birkbeck College at the University of London. Sunil Amrith grew up in Singapore, and received his undergraduate and graduate degrees from the University of Cambridge." + }, + { + "name": "Sergei Antonov", + "department": "History", + "profile_url": "https://history.yale.edu/people/sergei-antonov", + "fields_of_interest": "Russia after 1800 and Soviet Union; Russian and comparative legal history; Russian serfdom; global history of capitalism and credit; crime & criminal justice; secret political police; elites & power", + "bio": "Sergei Antonov specializes in modern Russia after 1800, with particular interest in politics, culture, and society in the late imperial and early Soviet period (ca. 1850-1927). His research focuses on the history of Russian law, conceived broadly to include not just legislation and legal doctrines, but ways in which legal norms and institutions impacted the daily practices of ordinary persons, rich and poor, men and women, and served to define and protect private interests, resolve (or perpetuate) interpersonal conflicts, as well as to assert (or challenge) social power and authority.\n\nProfessor Antonov’s first book,Bankrupts and Usurers of Imperial Russia: Debt, Property, and the Law in the Age of Dostoevsky and Tolstoy, appeared from Harvard University Press in 2016. It won the Ed A. Hewett Book Prize for an outstanding publication on the political economy of Russia, Eurasia and/or Eastern Europe, awarded by the Association for Slavic, East European, & Eurasian Studies. It is the first full-length history of the culture of personal debt in Russia. Based on close readings of previously unexamined court cases, it argues that informal personal debt was central to the imperial-era regime of private property, which, in turn, underpinned Russia’s social and political stability. Moreover, this culture of credit and private property was rooted in a reasonably efficient and vigorous legal culture and legal tradition, thus contradicting the commonly held view of Russian law as underdeveloped or even a “fiction.” Aiming to connect issues of money, capitalism, and the law to their broader cultural context, Professor Antonov’s book is intended for readers interested in a broad multidisciplinary perspective on imperial Russia during a crucial period of its history.\n\nProfessor Antonov’s current research projects focus on the culture of crime and criminal justice in late imperial Russia as well as on Russian serfdom as a legal regime. Some of this research has been published by Novoe Literaturnoe Obozrenie and is forthcoming from Slavic Review and Law and History Review. He earned his doctorate from Columbia in 2011 and his J.D. from NYU in 2002. His dissertation research was funded by an IREX IARO Research Scholarship and by the ACTR Research Scholar Program. Before coming to Yale, he taught at Columbia and the City University of New York, and was a postdoctoral fellow at the Harriman Institute, Columbia University, in 2012-2013. A native of Moscow, he came to the US in 1992 and earned his B.A. from Washington and Lee University, summa cum laude, in 1999." + }, + { + "name": "Lauren Benton", + "department": "History", + "profile_url": "https://history.yale.edu/people/lauren-benton", + "fields_of_interest": "Comparative empires; history of international law; Atlantic history; global and international history; British and Iberian empires", + "bio": "A comparative and world historian, Benton writes about global legal history and the history of European empires, especially British and Iberian empires. She completed her Ph.D. at Johns Hopkins University and holds an A.B. from Harvard University.Benton’s research gauges the effects of legal conflicts on global and international orders. Her most recent book,They Called It Peace: Worlds of Imperial Violence, analyzes imperial violence between 1400 and 1900. Previous works examine constitutionalism in empires, histories of imperial sovereignty, law in slavery and abolition, and legalities of piracy. Before focusing on global legal history, Benton conducted ethnographic research on the informal sector and economic development in Latin America and Spain.Benton is a recipient of the Toynbee Foundation Prize for significant contributions to global history. In 2022, she delivered the George Macaulay Trevelyan Lectures at the University of Cambridge. Other honors and awards include a Berlin Prize fellowship, a Guggenheim Foundation fellowship, and membership in the Institute for Advanced Studies.Before coming to Yale, Benton held faculty appointments at New York University and Vanderbilt University. She served as dean of humanities and dean of the graduate school at NYU and dean of arts and sciences at Vanderbilt. Benton was president of the American Society for Legal History in 2019-2020.Books:They Called It Peace: Worlds of Imperial Violence. Princeton University Press, (2024).Rage for Order: The British Empire and the Origins of International Law, 1800–1850, coauthored with Lisa Ford. Harvard University Press, 2016.A Search for Sovereignty: Law and Geography in European Empires, 1400–1900.Cambridge University Press, 2010.Law and Colonial Cultures: Legal Regimes in World History, 1400–1900.Cambridge University Press, 2002. Winner of the James Willard Hurst Prize of the Law & Society Association; the Jerry Bentley Book Prize of the World History Association; and the PEWS Immanuel Wallerstein Memorial Book Award of the American Sociological Association.Invisible Factories: The Informal Economy and Industrial Development in Spain.Anthropology of Work series, State University of New York Press, 1990.Coedited volumes:A World at Sea: Maritime Practices and Global History.Lauren Benton and Nathan Perl-Rosenthal, eds. University of Pennsylvania Press, 2020.Protection and Empire: A Global History.Lauren Benton, Adam Clulow, and Bain Attwood, eds. Cambridge University Press, 2017.Legal Pluralism and Empires, 1500–1850.Lauren Benton and Richard Ross, eds. New York University Press, 2013.The Informal Economy: Studies in Advanced and Less Developed Countries.Alejandro Portes, Manuel Castells, and Lauren Benton, eds. Johns Hopkins University press, 1989.Recent articles/chapters:“How Not to Possess an Island: Pitcairn and the Legal Circuits of British Empire in the Pacific World,” coauthored with Adam Clulow,Annales,7:4 (2024): 605-646.“A Sea of Households: Ordering Violence and Mobility Across the Interimperial Caribbean,” coauthored with Timo McGregor,Past & Present, Volume 265:17 (2024) 21-44.“Rights and Empires: Relations of Authority,” coauthored with Jane Burbank, in Dan Edelstein and Jennifer Pitts, eds.The Cambridge History of Rights, Vol. IV(Cambridge University Press, 2024), 437-462.“Interpolity Law and Jurisdictional Politics,” coauthored with Adam Clulow,Law and History Review3 (2023): 1-13.“Empire, Nation, and the International in the Mid-Century Atlantic.” Coauthored with Lisa Ford. InThe Rise of the International(Oxford University Press, 2023).“Interpolity Law.” InOxford Handbook of History and International Relations(Oxford University Press, 2023).“Protection Shopping among Empires: Suspended Sovereignty in the Cocos-Keeling Islands.”Past & Present, 257:1 (2022): 209-247. Coauthored with Adam Clulow." + }, + { + "name": "Paola Bertucci", + "department": "History", + "profile_url": "https://history.yale.edu/people/paola-bertucci", + "fields_of_interest": "Science and technology in the early modern world, cultures of collecting and display; artisanal knowledge, the early modern body, scientific travel, material culture, experimental philosophy", + "bio": "My work focuses on science, technology, and medicine in seventeenth- and eighteenth-century Europe. I am also broadly interested in the visual and material cultures of science and technology and the politics of display. I have published on artisanal cultures and the politics of encyclopedism in Old Regime France, on the social history of experimental physics in Italy and England, on the silk industry and industrial espionage within Europe and across the Atlantic. Most recently, my research and publications have addressed the intersections between HSTM and the history of craft and labor.\n\nI am the author of three monographs:\n\nMy most recent book,In the Land of Marvels. Science, Fabricated Realities, and Industrial Espionage in the Age of the Grand Tour(Johns Hopkins University Press, 2023) explores the relationship between science and eighteenth-century information cultures through the lens a medical controversy and its life on the printed page. I show that reputed experimenters and academicians, along with travel writers, eagerly manipulated facts to create fabricated realities. These fabrications in print, just like fake news circulating in the cybersphere, had real life effects: they secured or started careers, promoted new medical treatments, spread long-lasting stereotypes, and created imagined pasts.In the Land of Marvelsreceived the 2025 Paul Bunge prize for best book on the history of scientific instruments.\n\nI have been active in bringing insights from the History of Science to the broader public through collaborations with museums. Since 2012, I have served as the curator-in-charge of theHistory of Science and Technology Division of the Yale Peabody Museum, an activity that has most notably resulted in the first History of Science and Technology gallery at Yale (now open in the renovated Peabody Museum).  In 2023, I co-curatedCrafting Worldviews. Art and Science in Europe, 1500-1800a temporary exhibition at the Yale Art Gallery that showcased a selection of objects from the HST collection, addressing the intextricable connections among science, art, and European colonialism. Betweeen 2004 and 2007 I collaborated on the renovation of the Museum of the History of Science in Florence, now Galileo Museum, where I curated two permanent galleries:The Spectacle of ScienceandScience at Home.\n\nMy work has been acknowledged with the 2025 Paul Bunge prize for best book on the history of scientific instruments, the 2019 Louis Gottschalk prize for best book in eighteenth-century studies, the 2016 Margaret W. Rossiter Prize for best article on the history of women in science awarded by the History of Science Society, and the 2015 Clifford Prize for best article in 18th-century studies awarded by the American Society for Eighteenth Century Studies. In 2012 I received the Poorvu Family Award for Interdisciplinary Teaching from Yale College.\n\nIn 2024-2025, I served as the President of the American Society for Eighteenth Century Studies.\n\nBooks:\n\nIn the Land of Marvels. Science, Fabricated Realities, and Industrial Espionage in the Age of the Grand Tour(Baltimore: Johns Hopkins University Press, 2023). 2025 Paul Bunge Prize for best book on the history of scientific instruments, awared by the German Chemical Society and the Hans Jenemann Foundation.\n\nArtisanal Enlightenment: Science and the Mechanical Arts in Old Regime France(New Haven: Yale University Press, 2017). 2019 Louis Gottschalk Prize for best book on eighteenth-century studies, awarded by the American Society for Eighteenth-Century Studies. Second-prize winner, 2018 John Pickstone prize for best scholarly book in history of science and medicine, awarded every two years by the British Society for the History of Science. Finalist, Kenshur Prize for best book in 18th-century interdisciplinary studies.\n\nViaggio nel paese delle meraviglie. Scienza e curiosità nell’Italia del Settecento.Torino: Bollati Boringhieri, 2007\n\nElectric Bodies. Episodes in the History of Medical Electricity(co-edited with Giuliano Pancaldi), Bologna: CIS, University of Bologna, 2001\n\nArticles or book chapters:\n\n“Spinners Hands, Imperial Minds: Migrant Labor, Embodied Expertise, and the Failed Transfer of Silk Technology across the Atlantic,”Technology and        Culture62 (2021), 1003-1031.\n\n“Shocking Subjects. Human experiments and the material culture of medical electricity in eighteenth-century England”, in Erika Dick and Larry Stewart (eds),The Uses of Humans in Experiment: Perspectives from the 17thto the 20thCentury(Leiden and Boston: Brill, 2016)\n\n“Artisanal Knowledge, Expertise, and Patronage in Early 18th-Century Paris: TheSociété des Arts”,Eighteenth-Century Studies48 (2015), 159-179 (with Olivier Courcelle)\n\n“Enlightened Secrets: Silk, Industrial Espionage, and Intelligent Travel in 18th-century France”,Technology and Culture54 (2013): 820-52 (winner of the 2015 Clifford Prize from the American Society of Eighteenth Century Studies)\n\n“The In/visible Woman: Mariangela Ardinghelli(1730-1824) and the circulation of natural knowledge between Paris and Naples”,Isis104(2013): 226-49 (winner of the Margaret Rossiter Prize for best article on the history of women in science published in the previous four years, awarded by the History of Science Society)\n\n“The architecture of knowledge: Science, collecting and display in 18th-century Naples”, in Helen Hills, Melissa Calaresu (eds.),New Approaches to Neapolitan Culture c. 1500-1800: The power of place,Aldershot: Ashgate\n\n“Designing the house of knowledge in 18th-century Naples; the ephemeral museum of Ferdinando Spinelli, Prince of Tarsia”, in Jim Bennett, Sofia Talas (eds),Makin Science Public in the Eighteenth Century: The role of Cabinets of Experimental Philosophy.Brill (2013)\n\n“The spectacle of science”, in Filippo Camerota ed.,Galileo Museum. Masterpieces of scienceFlorence, 2010\n\n“Science in the Domestic Sphere”, Filippo Camerota ed.,Galileo Museum, Masterpieces of science,Florence, 2010\n\n“Les Leçons de physique expérimentale de l’abbé Nollet” inSciences et curiosités à la Cour de Versailles, Châteaude de Versailles,  2010\n\n“Enlightening Towers: Public Opinion, Local Authorities and the Reformation of Meterology in Eighteenth Century Italy,” inPlaying with Fire: The Cultural History of the Lightning Rod, P. Heering, O. Hochadel, D. Rhees (eds.), Philadelphia: The American Philosophical Society, 2009.\n\n“Domestic Spectacles: electrical demonstrations between business and conversation”, in Christine Blondel, Bernadette Bensaude-Vincent (eds.),Science and Spectacle in the European Enlightenment,Aldershot: Ashgate, 2008\n\n“Therapeutic attractions: early applications of electricity to the art of healing” in H.A. Whitaker, C.U.M. Smith, S. Finger (eds)Brain, Mind and Medicine: Essays in Eighteenth-Century Neuroscience,Boton: Springer, pp. 271-84, 2007\n\n“Sparks in the dark: the attraction of electricity in the eighteenth century”,Endeavour,31(2007), 88-93\n\n“Revealing sparks: John Wesley and the religious utility of electrical healing”,British Journal for the History of Science,39(2006), 341-62\n\n“Back from Wonderland: Jean Antoine Nollet’s Italian Tour (1749)”, in L. Evans, A. Marr(eds.),Curiosity and Wonder from the Renaissance to the Enlightenment, Aldeshot: Ashgate, pp. 193-211, 2006\n\n“Public utility and spectacular display: the Physics Cabinet of the Royal Museum in Florence”,Nuncius,21(2006), 323-36\n\n“Sparking Controversy: Jean Antoine Nollet and Medical Electricity South of the Alps”,Nuncius,20(2005), 153-187\n\n“Promethean Sparks: Electricity and the order of nature in the eighteenth century”, in S. Zielinski, S. Wagnermaier (eds.),Variantology1. Diverse Historical Approaches Towards an Archaeology of Media, Technology and the Arts, Cologne: Walther Konig, 2005\n\n“A philosophical business, Edward Nairne and the Patent Medical Electrical Machine (1782)”,History of Technology,23(2001), 41-58\n\n“The electrical body of knowledge: medical electricity and experimental philosophy in the mid-eighteenth century”, in P. Bertucci, G. Pancaldi (eds.),Electric Bodies. Episodes in the history of medical electricity, Bologna: CIS, Dipartimento di Filosofia, 2001\n\nD.Phil, University of Oxford\n\nM.Sc in “History of Science: Instruments, Museums, Science, Technology”, University of Oxford\n\nLaurea (B.Sc)summa cum laudein Physics, Department of Physics, University of Bologna" + }, + { + "name": "Ned Blackhawk", + "department": "History", + "profile_url": "https://history.yale.edu/people/ned-blackhawk", + "fields_of_interest": "Native American history & Native American law", + "bio": "Ned Blackhawk (Western Shoshone) is a Professor of History at Yale and was on the faculty from 1999 to 2009 at the University of Wisconsin, Madison. A graduate of McGill University, he holds graduate degrees in History from UCLA and the University of Washington and is the author ofViolence over the Land: Indians and Empires in the early American West(Harvard, 2006), a study of the American Great Basin that garnered half a dozen professional prizes, including the Frederick Jackson Turner Prize from the Organization of American Historians.In addition to serving in professional associations and on the editorial boards of American Quarterly and Ethnohistory, Professor Blackhawk has led the establishment of two fellowships, one for American Indian Students to attend the Western History Association’s annual conference, the other for doctoral students working on American Indian Studies dissertations at Yale named after Henry Roe Cloud (Winnebago, Class of 1910).Degrees ReceivedPh.D. in History, University of Washington, 1999Master’s Degree in History, University of California, Los Angeles, 1994Bachelor of Arts in Honours History, McGill University, 1992Select Grants and Honors (Since Receivin​g Ph.d.)Book of the Decade Award, Native American and Indigenous Studies Association (NAISA), for “one of the ten most influential books in Native American and Indigenous Studies in the first decade of the twenty-first century” 2011Diverse Magazine’s Under 40 Emerging Scholar Award 2009John C. Ewers Award for the best book on North American Indian Ethnohistory, Western History Association 2008Frederick Jackson Turner Award for the most significant first book in American History, Organization of American Historians 2007Erminie Wheeler-Voegelin Prize for the best book of the year, the American Society for Ethnohistory 2007William P. Clements Prize for the best non-fiction book on Southwestern America for 2006, Clements Center for Southwest Studies, Southern Methodist University 2007Robert M. Utley Award for the best book on the military history of the American Frontier, Western History Association 2007Lora Romero First Book Prize, American Studies Association 2007Faculty Guest Coach Program, Division of Intercollegiate Athletics, UW Madison 2006Summer Research Service Grant, Provost’s Office, UW Madison 2005Institute on Race and Ethnicity Campus Reading Award, UW Institute on Race and Ethnicity 2005Outstanding Mentor Award, The Ronald E. McNair Post-Baccalaureate Achievement Program, University of Wisconsin, Madison 2005Visiting Faculty Fellowship, Research Institute of Comparative Studies in Race and Ethnicity, Stanford University 2004Postdoctoral Award, Ford Foundation Postdoctoral Fellowship Program, National Research Council 2001Select Editorial​ Positions and Service in Professional AssociationsErminie Wheeler-Voegelin Prize Committee, American Society for Ethnohistory 2011American Indian Advisory Board, Utah Museum of Natural History “Native Voices” Permanent Exhibition Design Team 2011Series Co-Editor, Henry Roe Cloud Series on American Indians and Modernity, Yale University Press (founding editor in Fall 2010) 2011Series Co-Editor, Cambridge Studies in North American Indian History, Cambridge University Press 2010-presentFrederick Douglas Prize Committee, Gilder Lehrman Center for the Study of Slavery, Resistance, and Abolition, Yale University Faculty Representative 2010Humanities Grant Panel Review, National Endowment for the Humanities 2010American Indian Advisory Board-Museum Design Team, Utah Museum of Natural History 2010Frederick Jackson Turner Prize Committee, Organization of American Historians 2010John Ewers Prize Committee, Western History Association 2010Editorial Board, Ethnohistory, the American Society for Ethnohistory 2008-presentAdvisory Board, American Quarterly, American Studies Association 2007-presentProgram Committee, Western History Association 2008 Conference 2007Gibson Award Committee 2004, Western History Association (Best Article of the Year in North American Indian History). 3-year appointment, 2004-06, Chair ‘06Conference Program Committee Member, “American Studies and the Question of Empire: Histories, Cultures and Practices,” American Studies Association, 1998" + }, + { + "name": "David Blight", + "department": "History", + "profile_url": "https://history.yale.edu/people/david-blight", + "fields_of_interest": "Civil War & Reconstruction era; African American history; American cultural & intellectual history", + "bio": "David W. Blight  is Sterling Professor of American History at Yale University, joining that faculty in January, 2003.  He previously taught at Amherst College for thirteen years.  As of June, 2004, he is Director, succeeding David Brion Davis, of the Gilder Lehrman Center for the Study of Slavery, Resistance, and Abolition at Yale.  In 2013-14 he was the William Pitt Professor of American History at Cambridge University, UK, and in 2010-11, Blight was the Rogers Distinguished Fellow in 19thcentury American History at the Huntington Library, San Marino, CA.   During the 2006-07 academic year he was a fellow at the Dorothy and Lewis B. Cullman Center for Writers and Scholars, New York Public Library.  He is currently writing a new, full biography of Frederick Douglass that will be published by Simon and Schuster in 2015.  Blight works in many capacities in the world of public history, including on boards of museums and historical societies, and as a member of a small team of advisors to the 9/11 Memorial and Museum team of curators.  For that institution he wrote the recently published essay, “Will It Rise: September 11 in American Memory.”  In 2012, Blight was elected to the American Academy of Arts and Sciences and delivered an induction address, “The Pleasure and Pain of History.”\n\nBlight’s newest books include annotated editions, with introductory essay, of Frederick Douglass’s second autobiography,My Bondage and My Freedom(Yale Univ. Press, 2013), Robert Penn Warren’sWho Speaks for the Negro, (Yale Univ. Press, 2014), and the monograph,American Oracle: The Civil War in the Civil Rights Era(Harvard University Press, published August 2011), which received the 2012 Anisfield-Wolf Award for best book in non-fiction on racism and human diversity.American Oracleis an intellectual history of Civil War memory, rooted in the work of Robert Penn Warren, Bruce Catton, Edmund Wilson, and James Baldwin.  Blight is also the author ofA Slave No More: Two Men Who Escaped to Freedom, Including their Narratives of Emancipation, (Harcourt, 2007), paperback in 2009.  This book combines two newly discovered slave narratives in a volume that recovers the lives of their authors, John Washington and Wallace Turnage, as well as provides an incisive history of the story of emancipation.  In June, 2004, theNew York Timesran a front page story about the discovery and significance of these two rare slave narratives.A Slave No Moregarnered three book prizes, including the Connecticut Book Award for non-fiction.  Blight recently published the articles, “The Theft of Lincoln in History, Politics, and Memory,” inOur Lincoln, Eric Foner, ed., (2008); and “Hating and Loving the ‘Real’ Abe Lincolns: Lincoln and the American South,” in Richard Carwardine and Jay Sexton, eds.,The Global Lincoln, (Oxford Univ. Press, 2011); “Mirror of Memory,”American Interest, August, 2011; and numerous op-ed columns for newspapers, including theNew York Timesand theNew York Daily News.\n\nBlight is also the author ofRace and Reunion: The Civil War in American Memory(Harvard University Press, 2001), which received eight book awards, including the Bancroft Prize, the Abraham Lincoln Prize, and the Frederick Douglass Prize as well as four awards from the Organization of American Historians, including the Merle Curti prizes for both intellectual and social history.   Other published works include a book of essays, Beyond the Battlefield: Race, Memory, and the American Civil War(University of Massachusetts Press, 2002); andFrederick Douglass’s Civil War: Keeping Faith in Jubilee(LSU Press, 1989).  Blight is the editor of and author of introductions for six other books, includingWhen This Cruel War Is Over: The Civil War Letters of Charles Harvey Brewster(Univ. of Massachusetts Press, 1992);Narrative of the Life of Frederick Douglass, An American Slave(Bedford Books, 1993); co-editor with Robert Gooding-Williams, W.E.B. Du Bois,The Souls of Black Folk(Bedford Books, 1997); co-editor with Brooks Simpson,Union and Emancipation: Essays on Politics and Race in the Civil War Era(Kent State Univ. Press, 1997); and Caleb Bingham,The Columbian Orator(orig. 1797, NYU Press, 1997), the book of oratory and antislavery writings that Frederick Douglass discovered while a youth.  The edited volume,Passages to Freedom: The Underground Railroad in History and Memory, was published by Smithsonian Press in 2004 and is the companion book for the opening of the National Underground Railroad Freedom Center in Cincinnati.\n\nBlight is also a frequent book reviewer for theNew York Times,Washington Post Book World, theChicago Tribune, theLos Angeles Times, the San Francisco Chronicle, theBoston Globe,Slate.comand other newspapers, and has written many articles on abolitionism, American historical memory, and African American intellectual and cultural history.   He is one of the authors of the bestselling American history textbook for the college level,A People and a Nation(Houghton Mifflin).  He is also series advisor and editor for the Bedford Books series in American History and Culture, a popular series of teaching books for the college level.  Blight lectures widely in the US and around the world on the Civil War and Reconstruction, race relations,  Douglass, Du Bois, and problems in public history and American historical memory.  He teaches summer institutes for secondary teachers and for park rangers and historians in the National Park Service, devoting a good deal of time to these and many other public history initiatives.\n\nBlight has been a consultant to many documentary films, including, “Death and the Civil War,” (2012), the 1998 PBS series, “Africans in America,” and “The Reconstruction Era” (2004) among others.  Blight has a Ph. D. from the University of Wisconsin-Madison, and did his undergraduate degree at Michigan State University.  He has also taught at Harvard University, at North Central College in Naperville, Illinois, and for seven years was a public high school teacher in his hometown, Flint, Michigan.  He was also senior Fulbright Professor in American Studies at the University of Munich in Germany in 1992-93.\n\nBlight was elected as a member of the Society of American Historians in 2002, and served as that Society’s President in 2013-14.  Board of Trustees or Advisory Board memberships include the New York Historical Society, the Benjamin Franklin Papers at Yale, the National Underground Railroad Freedom Center in Cincinnati, the National Civil War Center at Tredegar in Richmond, VA, Executive Board of the Organization of American Historians, and the board for African American Programs at Monticello in Charlottesville, VA.  He also served on the board of advisors to the Abraham Lincoln Bicentennial Commission and is involved in planning numerous conferences and events to commemorate the sesquicentennial of the Civil War.  In his capacity as director of the Gilder Lehrman Center at Yale, Blight organizes conferences, working groups, lectures, the administering of the annual Frederick Douglass Book Prize, and many public outreach programs regarding the history of slavery and its abolition.  Blight maintains a professional web site atdavidwblight.comand his lectures for the course, “The Civil War and Reconstruction Era,” are available on line at the Yale University web site,Opencourses.Yale.edu.  In 2009, Blight chaired the jury for non-fiction for the National Book Award." + }, + { + "name": "Daniel Botsman", + "department": "History", + "profile_url": "https://history.yale.edu/people/daniel-botsman", + "fields_of_interest": "Japanese history", + "bio": "Daniel Botsman teaches courses on the history of Japan from 1500 to the present.\n\nBorn in Lae, Papua New Guinea (site of one of the many brutal battles fought between Allied and Japanese forces during the Second World War), he spent his formative years in Brisbane, Australia, where he was introduced to the Japanese language at a young age.  After an extended visit to Osaka as a high school student the study of Japanese history and society quickly became a guiding intellectual passion.  He went on to complete his B.A. in Asian Studies (Hons.) at the Australian National University in Canberra and was awarded the 1992 Rhodes Scholarship for his home state of Queensland. After two years at Merton College, Oxford, where he received an M.Phil. in Economic and Social History, he completed his graduate studies at Princeton University, earning his Ph.D. in History in 1999.\n\nHis first academic appointment was in the Faculty of Law at Hokkaido University in Sapporo, where he taught for a year before returning to the United States to take up a position in the history department at Harvard.  In 2006 he moved to the University of North Carolina at Chapel Hill, where he was recipient of the James M. Johnston Award for Excellence in Teaching.\n\nBotsman’s publications include a translation of the memoirs of a prominent post-war foreign minister,Okita Saburo: A Life In Economic Diplomacy(Canberra: Australia-Japan Research Center, 1993), and a study of the history of punishment from the 16th to the 20th centuries,Punishment and Power in the Making of Modern Japan(Princeton: Princeton University Press, 2005), also available in Japanese asChi nurareta jihi, muchi utsu teikoku(Tokyo: Intershift, 2009).\n\nHis current research examines the impact that Western ideas about slavery and emancipation had on Japanese society in the second half of the nineteenth century, focusing particularly on the experiences of Japan’s outcaste communities." + }, + { + "name": "Paul Bushkovitch", + "department": "History", + "profile_url": "https://history.yale.edu/people/paul-bushkovitch", + "fields_of_interest": "Russia to 1800; Russian foreign policy, Orthodoxy, and empire", + "bio": null + }, + { + "name": "Deborah Coen", + "department": "History", + "profile_url": "https://history.yale.edu/people/deborah-coen", + "fields_of_interest": "History of the modern physical and environmental sciences; Central European intellectual and cultural history", + "bio": null + }, + { + "name": "Rohit De", + "department": "History", + "profile_url": "https://history.yale.edu/people/rohit-de", + "fields_of_interest": "Modern South Asia (India, Pakistan, Bangladesh), Global Legal History, Law and Society, Law and Colonialism, British Empire, Nationalism and Decolonization in Asia and Africa, Comparative Constitutionalism", + "bio": "Rohit De is a lawyer and historian of modern South Asia and focuses on the legal history of the Indian subcontinent and the common law world.  As a legal historian he moves beyond asking what the law was; to what actors thought law was and how this knowledge shaped their quotidian tactics, thoughts and actions. In recent years, this has enabled his research to move beyond the political borders to South Asia to uncover transnational legal geographies of commerce, migration and rights across East Africa, Southeast Asia and the Caribbean.His bookA People’s Constitution: Law and Everyday Life in the Indian Republic(Princeton University Press, 2018) explores how the Indian constitution, despite its elite authorship and alien antecedents, came to permeate everyday life and imagination in India during its transition from a colonial state to a democratic republic.A People’s Constitutionwon the Willard C Hurst Prize for the Best Book on Socio-Legal History from the Law and Society Association, the Heyman Prize in the Humanities from Yale University, the sole Honorable Mention for the Peter Gonville Stein Prize from the American Society for Legal History and was a finalist for the Kamaladevi Chattopadhayay Prize from the New India Foundation. It is currently being translated into Hindi, Marathi, Tamil and Malayalam.His second book,Assembling the Indian Constitution, coauthored with Ornit Shani, examines at how thousands of ordinary Indians, read, deliberated, debated and substantially engaged with the anticipated constitution at the time of its writing and will be published in 2023.He was awarded a Carnegie Fellowship in 2020 to support his research onRights from the Left: Decolonization, Diasporas and a Global History of Rebellious Lawyering, whichfollows the careers of lawyers who defended unpopular causes across borders and over time, to offer an alternate history of universal rights and civil liberties that arise out of Asia and Africa and is mediated through India, Chinese and Caribbean diasporas. It charts how political trials and social movement lawyering in in Kenya, Tanzania, Ghana, Seychelles, India, Pakistan,  Bangladesh, Sri Lanka, Malaysia, Singapore, Jamaica, British Guyana and the United Kingdom, were produced by, and as part of, a transnational movement for civil liberties. The project also supported by the SSRC stands at the intersection of multiple fields: histories of human rights; decolonization and the Cold War; diaspora studies; and history of the legal profession.Prof De is also interested in comparative constitutional law and is anAssociate Research Scholar in Lawat the Yale Law School. He has assisted Chief Justice K.G. Balakrishnan of the Supreme Court of India and worked on constitution reform projects in Nepal and Sri Lanka. He writes on contemporary legal issues in South Asia.Prof De received his Ph.D from Princeton University, where he was elected to the Society of Woodrow Wilson Scholars. His dissertation won the Law and Society Association Prize for best representing outstanding work in law and society research in 2013. He has held fellowships from the Social Science Research Council, the Davis Centre for Historical Studies at Princeton University, the Melbourne Law School, and the Centre for Asian Legal Studies at the National University of Singapore.He was the Mellon Postdoctoral Fellow at the Centre for History and Economics and a fellow of Trinity Hall at the University of Cambridge before coming to Yale in 2014.  Rohit received his law degrees from the Yale Law School and the National Law School of India University, Bangalore.Rohit teaches undergraduate and graduate courses on South Asian history; postcolonial histories of India, Pakistan and Bangladesh; on Indian constitutional culture and political thought, South Asian diasporas and migration as well as courses on global legal history, law and colonialism and the legal profession. You can learn more about his work in his interview in theYale Historical Reviewand theMacmillan Report.BooksA People’s Constitution: Law and Everyday Life in the Indian Republic(Princeton University Press, 2018)Book Launch and Panel Discussionat India International Centre, New Delhi, January 8, 2019Interview on NDTV India: Prime Timeon A People’s Constitution. Nov 23, 2018Assembling India’s Constitution (coauthored with Ornit Shani) (Cambridge University Press, 2023)A Jurisprudence of Decolonization: Civil Liberties, Diasporas and a Global History of Rebellious Lawyers (draft in progress)Refereed Articles and Peer Reviewed Chapters(with Ornit Shani),”Assembling India’s Constitution: Towards a New History”,Past and Present, May 2023“The Possibilities of Anti-Colonial Constitutionalism: A Commentary onState of West Bengal v. Anwar Ali Sarkar, AIR 1952 SC 75, VRÜ Verfassung und Recht in Übersee , Issue 1 (2023) 33-47.“The Jurisprudence of Decolonization: The Postcolonial Career of D.N Pritt and the Practice of Rebellious Lawyering”, Humanity (forthcoming)“Empire of Laws”, Cambridge History of the Indian Subcontinent, Volume 3 (David Gilmartin, Manu Goswami and Mrinalini Sinha, editors)   (under review)The Indian Constitution: Moment, Epics and Everyday Lives”.  International Journal of Constitutional Law, 18 (3) 2020, 1022-1030Between Midnight and Republic: Theory and Practice of India’s Dominion Status,  Volume 17: Issue 4 International Journal of Constitutional Law, 2019Petitioning and Political Cultures in South Asia, coauthored with Robert Travers, Modern Asian Studies, Volume 53, Issue 1. 2019 p. 1-20.Cows and Constitutionalism, Modern Asian Studies Volume 53, Issue 1. 2019 p. 240-247.The Republic of Petty Bureaucrats: Upendra Baxi and the Pathology of Civil Service Jurisprudence, Jindal Global Law Review (2019), Vol 9, Issue 2, 2018, 335-350.“Lawyering as Politics: The Legal Career of Dr. Ambedkar, Bar-at-Law”, in Suraj Yengde and Anand Telbumbe eds., The Radical in Ambedkar: Critical Reflections, (Penguin: London and New Delhi, 2018).“Evacuee Property and the Management of Economic Life in Postcolonial India” in Gyan Prakash, Michael Laffan and Nikhil Menon eds.,The Postcolonial Moment in South and South-east Asia(London: Bloomsbury, 2017)Constitutional AntecedentsinThe Oxford Handbook to the Indian Constitution, Sujit Choudhary, Madhav Khosla and Pratap Bhanu Mehta eds.,(New York: Oxford University Press, 2015)A Peripatetic World Court” Cosmopolitan Courts, Nationalist Judges and the Indian Appeal to the Privy Council.”Law and History Review32, no. 04 (2014): 821-851.Rebellion, Dacoity, and Equality The Emergence of the Constitutional Field in Postcolonial India.Comparative Studies of South Asia, Africa and the Middle East34, no. 2 (2014): 260-278.‘Commodities must be controlled’: Economic Crimes and Market Discipline in India (1939–1955).International Journal of Law in Context10, no. 03 (2014): 277-294.“The Federal Court and Civil Liberties in Late Colonial India” in T. Halliday, L. Karpik, M. Feeley (eds.)Fates of Political Liberalism in the British Post-Colony: The Politics of the Legal Complex(Cambridge: Cambridge University Press, 2012) pp.59-90“Beyond the Social Contract“Seminar Magazine: Special Issue on 60 years of the Indian Constitution,November 2010“The Two Husbands of Vera Tiscenko: Apostasy, Conversion and Divorce in Late Colonial India” 28 (4)Law and History Review(2010) pp.1011-1041“MumtazBibi’s Broken Heart: The Many Lives of the Dissolution of Muslim Marriages Act, 1939”46:1Indian Economic and Social History Review( 2009) pp.105-130 (Co-author)(Co-author) “Introduction: Personal Law, Identity Politics and Civil Society in Colonial South Asia” 46:1Indian Economic and Social History Review( 2009) pp.1-4Special Issues Edited(with Robert Travers) “Petitioning and Political Cultures in South Asia”, Modern Asian Studies, Vol 53, Issue 1 (2019)Translations of Work“Samajik Karak se Pare”, in Pranjal, Shipra Kiran and Sanjeev Kumar eds.,किसका संविधान, किसका देश?(वाम प्रकाशन,New Delhi, 2020) 66-80“The Case of the Honest Prostitute: Sex, Work and Freedom in the Indian Republic” (translated to Japanese), 雑誌 都市文化研究 (Studies in Urban Culture) (forthcoming Dec 2020)“हम अब भारतीय गणतंत्र का एक और पुनराविष्कार देख रहे हैं !” (Pamphlet)Book Reviews and Essays“How to Write New Constitutional Histories? The Casebook of Everyday Life.” Asian Journal of Comparative Law 15, no. 2 (2020): 394-401.Reviewof Aakash Singh Rathore, Ambedkar’s Preamble: A Secret History of the Constitution of India (2020), Outlook IndiaMurder Mystery, Legal History: Three Essays,Legal History Blog, 24thMay 2020, 27thMay 2020, 4thJune, 2020.“Revolutionary Lives and Afterlives: Archives, Gender and Region”, Book Roundtable: New Histories of Political Violence and Revolutionary Terrorism in Modern South Asia, South Asia: History and Culture, (2019) 10(3), pp.340-360.“The Once and Future Constitution”, India Today¸ May 3rd2019.“Sedition, Securitization and Sexuality: A Conversation Between Rohit De and Inderpal Grewal”, South Asia Multidisciplinary Academic Journal (SAMAJ) May 2 (20) (2019)“South Asian Legal Culture,. In: James D. Wright (editor-in-chief), International Encyclopaedia of the Social & Behavioral Sciences, 2nd edition, Vol 23. Oxford: Elsevier. pp. 58-62, 2015Law, Disorder and the Colonial State: Corruption in Burma c.1900 (London: Palgrave Macmillan, 2012)South Asia History and Culture6 (2), 310-313 (2014)Constitutional Nationalism and Legal Exclusion: Equality, Identity Politics and Democracy in Nepal (Oxford University Press, 2012) in  5 (Winter) Journal of Indian Law and Society (2014)“Tools of Justice: Non‐discrimination and the Indian Constitution. By Kalpana Kannabiran. New Delhi: Routledge, 2012. 505 pp. Rs 995, $105.00 cloth.“Law & Society Review48, no. 3 (2014): 687-689.“Litigation”, R.Dwyer, G. Dharmpal Frick, J.Phalkey and M. Kirloskar-Steinbach (eds.) Key Concepts in Modern Indian Studies (Oxford University Press, New Delhi, 2013).“Jurist’s Prudence: The Indian Supreme Court’s Responses to Institutional Challenges” , ICONNECT Blog, December, 12, 2012Opinion Pieces and Essays“ The Constitution Has Always Inspired Indians to Question Power” Indian Express, Jan 26, 2020.“For People to Wield this Bound Aaron’s Rod”, Outlook India Magazine, December 25, 2019,Co-author with Surabhi Ranganathan, “We are Witnessing the Rediscovery of India’s Republic” New York Times, December 27, 2019,Coauthored with Tarunabh Khaitan, “What Constitutionalism Calls For: The Judges Who Called out the Institutional Breach are not the Mutineers”, Times of India, Jan 16, 2018“No, the Uniform Civil Code was not deferred just for Muslims” Times of India, September 28, 2017“A Nuanced Judgment”, Frontline, September 15, 2017“Who Moved my Beef? Regulatory Change and the Pink Revolution” Nov 18, 2013, Hindu Business Line“What Didi Wants: The Case for a Federal Front”,The Indian Express,April 22, 2014“Personal Laws: A Reality Check” (Cover Story), Frontline, September 16, 2013,“Civil and Uncivil Codes”, India in Transition Series, Centre for the Advanced Study of India, University of Pennsylvania, Jan 2011“The Legal Career of Mohammad Ali Jinnah”,10thNovember, 2010 (2 parts)“Mirror Images”, The Indian Express, 29th August, 2009Online Talks, Interviews and PodcastsIndian Blog of International Law, April 3, 2022Digging a Hole: A Legal Theory Podcast,Episode 33,March 10, 2022“A Constitution as a Sword and a Shield”, Newsclick.in, Jan 26, 2022India Colonised, Episode 26, 2021Puliyabaazi, Episode 82,Ek Jan Samvidhan, Jan 26 2021“People are Protesting to Remind the Government of Constitutional Values”, Economic Times, Jan 26, 2020“A People’s Digital Republic”, LiveLaw India, Jan 14, 2020“Prime Time with Ravish Kumar”, NDTV India, 23 Nov 2018“The Kenyatta Trial: An International Legal Event”, NALSAR, Hyderabad, 2016“Vakil Raj and Swaraj: The legal careers of Motilal Nehru, Jinnah and Ambedkar”, Nehru Memorial Museum and Library, January 2014.“The Republic Without a Pub is  Relic: Prohibition and the Everyday Life of Constitutional Law in the Indian Republic”, King’s India Institute, London 2013." + }, + { + "name": "Carolyn J. Dean", + "department": "History", + "profile_url": "https://history.yale.edu/people/carolyn-j-dean", + "fields_of_interest": "Cultural and intellectual history of modern Europe; history of gender and sexuality; genocide studies and the Holocaust of European Jewry", + "bio": "Carolyn J. Dean is Charles J. Stille Professor of History and French.  She is a historian of modern Europe with a focus on the twentieth century whose work explores the intersection of ideas and culture, most recently in the context of genocide.  Her latest book,The Moral Witness: Trials and Testimony after Genocide(Cornell, forthcoming 2019) traces the history of the witness to genocide, tracking the changing representation of violence over the last hundred years and demonstrating how the cultural meaning of genocide was distinguished from war and imperial conquest.  She is the author of five other books that focus on the historical and cultural representation of victims, most recentlyAversion and Erasure: The Fate of the Victim after the Holocaust(Cornell, 2010) andThe Fragility of Empathy after the Holocaust(Cornell, 2004).  She has also written extensively about gender and sexuality in France and on the intellectual history of French theory.  She held the John Hay Professor of International Studies at Brown University, where she taught before coming to Yale in 2013, and has been the recipient of several fellowships, including an ACLS and a Guggenheim, among others. In 1996 she was awarded Professor of the Year by the Carnegie Foundation for the Advancement of Teaching and Council for the Advancement of Support of Education." + }, + { + "name": "Fabian Drixler", + "department": "History", + "profile_url": "https://history.yale.edu/people/fabian-drixler", + "fields_of_interest": "Japanese history; Demographic history around the world", + "bio": "Fabian Drixler teaches Japanese history. He is particularly interested in cultural history and historical demography, approaches that converge in his dissertation,Infanticide and Fertility in Eastern Japan: Discourse and Demography, 1660-1880(Harvard 2008).  This study charts the rise and destruction of a premodern society in which couples raised only two to three children. Highlighting the role of contingency and individual agency in demographic history, it connects population patterns with changing understandings of human life, political space, and the nature of time.\n\nCourses taught in 2008/2009:\n\nHistory 327J       Navigating Life in Nineteenth-Century Japan\n\nHistory 885        Readings in Japanese History from 1600\n\nHistory 306        East Asia, 500 to the Present (with Peter Perdue)\n\nHistory 325J       Infanticide and Foundlings in Asia and Europe Before 1900" + }, + { + "name": "Maura Dykstra", + "department": "History", + "profile_url": "https://history.yale.edu/people/maura-dykstra", + "fields_of_interest": "Early modern China; Ming and Qing China; empire and governance; legal history; bureaucratic history; institutional history; economic history; municipal governance; histories of information and administration", + "bio": "Maura Dykstra is a historian of Ming and Qing China with an interest in comparative histories of empire and the transition from empire to nation-state. She maintains an active research interest in the institutions of governance and administration at the local level, in the imperial capital, and in the many offices between the center and locale. Many of her recent and current projects revolve around questions about the use of text to represent local realities in imperial contexts.Dykstra’s first book,Uncertainty in the Empire of Routine: The Administrative Revolution of the Eighteenth-Century Qing State(Harvard University Asia Center Press, 2022), traces the “double-stranded tale of the development of the Qing bureaucracy and its archive” from the hundred years after the Qing conquest of the Ming to the middle of the eighteenth century,Her next book-length project continues several of the lines of inquiry from her first book, including its focus on the relationship between textual practices of administration and the epistemological foundations of the state, into county-level archives and administration. This forthcoming project reviews the evolution of the material practices of day-to-day administration in the counties of the Qing Empire over the course of the nineteenth century.One of the main focal points of this project—the local litigation cases whose rediscovery and wide use by scholars in the late 1990s and early 2000s revolutionized the field of Chinese legal history—is the foundation of several new reflections about the relationship between code and case in the institutional context of imperial Chinese law. This interest in and attention to the material and procedural foundations of law and administration in Chinese history inspired Dykstra to create a five-year working group on the Chinese Legal Tradition, which is hosted by the Max Planck Institute for Legal Theory and Legal History.A third book-scale research endeavor covers the history of Ming and Qing colonization of the Southwest, with a focus on the Sichuan-Hunnan-Guizhou border region. Some of her thoughts about how to re-frame the colonization of the Southwest as a part of the broader history of the Ming and Qing Empires are at the heart of her undergraduate lecture course H315, “State of War: Conflict, Conquest, and Consolidation in Late Imperial China.”In addition to the above-listed institutions which have hosted her research and multi-year projects, Dykstra has held fellowships and residential positions at East China Normal University, the Taiwan Center for Chinese Studies, The Tokyo University Graduate School of Law and Politics, the Max Planck Institute for the History of Science, and the Harvard University Fairbank Center for Chinese Studies.Recent PublicationsUncertainty in the Empire of Routine: The Administrative Revolution of the Eighteenth-Century Qing State.Cambridge, Mass.: Harvard University Asia Center Press. 2022.“A Crisis of Competence: Information, Corruption, and Knowledge about the Decline of the Qing State,”Journal of the History of Knowledge1, no. 1 (2020). (https://doi.org/10.5334/jhk.11“Growing up before the Rebellion: Merchant Organization and Local Administration in Chongqing,”Late Imperial China43, no. 1 (June, 2022): 1-42. (https://doi.org/10.1353/late.2022.0003)Selected AwardsCaltech Richard P. Feynman Prize for Excellence in Teaching – 2021HSS Brass Award for Diversity, Equity, and Inclusion – Caltech Division of Humanities and Social Sciences 2021Dr. Fred Shair Programming Diversity Award – Caltech Center for Inclusion and Diversity – 2021ASCIT Teaching Award – Caltech Associated Students – 2019The Henry Luce Foundation/ACLS Program in China Studies Grant – 2015-2016Thomas Lifka Dissertation Prize Winter 2014" + }, + { + "name": "Marcela Echeverri Muñoz", + "department": "History", + "profile_url": "https://history.yale.edu/people/marcela-echeverri-mu-oz", + "fields_of_interest": "History of social sciences, gender and nationalism; political theory and state formation; Spanish empire and Atlantic world; Revolutionary Age, race and ethnicity; slavery and abolition; twentieth-century Latin American social thought", + "bio": "“Royalists, Monarchy, and Political Transformation in the Spanish Atlantic World during the Age of Revolutions.” InThe Cambridge History of the Age of Atlantic Revolutions, Volume 3: The Iberian Empires. Edited by Wim Klooster. New York: Cambridge University Press, 2023, pp. 277-303." + }, + { + "name": "Carlos Eire", + "department": "History", + "profile_url": "https://history.yale.edu/people/carlos-eire", + "fields_of_interest": "Early modern Europe; Intellectual, social, cultural & religious history; Protestant and Catholic Reformations", + "bio": "Carlos Eire, who was awarded the 2024 Harwood F. Byrnes/Richard B. Sewall Teaching Prize by Yale College, received his PhD from Yale in 1979.   He specializes in the social, intellectual, religious, and cultural history of late medieval and early modern Europe, with a focus on both the Protestant and Catholic Reformations; the history of popular piety; the history of the supernatural, and the history of death.  Before joining the Yale faculty in 1996, he taught at St. John’s University in Minnesota and the University of Virginia, and was a member of the Institute for Advanced Study in Princeton.  He is the author of  War Against the Idols (1986); From Madrid to Purgatory (1995); A Very Brief History of Eternity (2010); Reformations: The Early Modern World (2016);  The Life of Saint Teresa of Avila: A Biography (2019); and They Flew: A History of the Impossible (2023).  He is also co-author of Jews, Christians, Muslims: An Introduction to Monotheistic Religions (1997); and ventured into the twentieth century and the Cuban Revolution in the memoir Waiting for Snow in Havana (2003), which won the National Book Award in Nonfiction in the United States and has been translated into more than a dozen languages.  His second memoir, Learning to Die in Miami (2010), explores the exile experience.  A past president of the Society for Reformation Research, he is currently researching various topics in the history of the supernatural. His book Reformations won the R.R.Hawkins Prize for Best Book of the Year from the American Publishers Association, as well as the award for Best Book in the Humanities in 2017. It was also awarded the Jaroslav Pelikan Prize by Yale University Press.  All of his books are banned in Cuba, where he has been proclaimed an enemy of the state – a distinction he regards as the highest of all honors." + }, + { + "name": "Omnia El Shakry", + "department": "History", + "profile_url": "https://history.yale.edu/people/omnia-el-shakry", + "fields_of_interest": "Intellectual and cultural history of the modern Middle East; race, religion, gender, and sexuality in the modern Middle East; history of colonialism; psychoanalysis and critical theory", + "bio": "Omnia El Shakry specializes in the intellectual and cultural history of the modern Middle East, with a particular emphasis on the history of the human and religious sciences in modern Egypt. El Shakry is the author ofThe Arabic Freud: Psychoanalysis and Islam in Modern Egypt(Princeton University Press, 2017) andThe Great Social Laboratory: Subjects of Knowledge in Colonial and Postcolonial Egypt(Stanford University Press, 2007). She is also the editor ofUnderstanding and Teaching the Modern Middle East(University of Wisconsin Press, 2020) andGender and Sexuality in Islam(Routledge, 2016). Her work has been supported by grants and fellowships from the American Council of Learned Societies, the Fulbright Program, the National Endowment for the Humanities, and the Stanford Humanities Center. El Shakry received her BA in Psychology from the American University in Cairo, an MA in Near Eastern Studies from New York University, and her PhD in History from Princeton University. Prior to coming to Yale, she taught for twenty years in the History Department at the University of California, Davis." + }, + { + "name": "Anne Eller", + "department": "History", + "profile_url": "https://history.yale.edu/people/anne-eller", + "fields_of_interest": "Latin America and the Caribbean, Emancipation, Haitian and Dominican studies; African Diaspora; Independence and Decolonization", + "bio": "“Into the Hills: Challenges of Writing Post-Emancipation Agency in the Caribbean.”Journal of Social History57:3(Spring 2024), 404-410.\n\n“Beyond a Revolution:The Common Windat a Nadir.” In H-Net Haiti’sForum on the Common Wind: In Honor of Julius S. Scott. Julia Gaffield and Marlene L. Daut, eds." + }, + { + "name": "David Engerman", + "department": "History", + "profile_url": "https://history.yale.edu/people/david-engerman", + "fields_of_interest": "Twentieth-century international history", + "bio": "David C. Engerman is a scholar of twentieth-century international history.  Building on his dual training in American and Russian/Soviet history at the University of California-Berkeley (where he received his Ph.D. in 1998), he wrote two books on the place of Russia and the USSR in American intellectual and political life: Modernization from the Other Shore: American Intellectuals and the Romance of Russian Development (Harvard UP, 2003) and Know Your Enemy: The Rise and Fall of America’s Soviet Experts (Oxford UP, 2009).\n\nHe has also researched and written on a variety of topics related to the history of development assistance, including a co-edited volume, Staging Growth: Modernization, Development and the Global Cold War (U-Mass Press, 2003), and most recently a monograph, The Price of Aid: The Economic Cold War in India (Harvard UP, 2018).  This research was also the topic of his presidential address for the Society for Historians of American Foreign Relations in 2016.  Research for The Price of Aid was supported by grants and fellowships from the American Council of Learned Societies, the American Institute of Indian Studies, the American Philosophical Society, the Guggenheim Foundation, the Kennan Institute for Advanced Russian Studies, the National Council for Eurasian and East European Studies, the National Endowment for the Humanities, and the Eisenhower, Johnson and Truman presidential libraries.\n\nEngerman joins the faculty at Yale after nineteen years at Brandeis University.  His new research focuses on the geopolitics of international economic inequality in the second half of the twentieth century." + }, + { + "name": "Hussein Fancy", + "department": "History", + "profile_url": "https://history.yale.edu/people/hussein-fancy", + "fields_of_interest": "Medieval European and Islamic History; Medieval Iberia and North Africa; Social History; Intellectual History; Economic History; Legal History; Latin and Arabic Paleography", + "bio": "Hussein Fancy is a historian of medieval Europe and the Islamic world.  His research and writing focus on the economic, social, legal, and intellectual history of interaction between Jews, Christians, and Muslims in the medieval Mediterranean.  In particular, he pursues projects that combine Latin, Arabic, and Romance archival sources.Fancy’s first book,The Mercenary Mediterranean, examined the service of Muslim soldiers from North Africa to the Christian kings of the Crown of Aragon in the thirteenth and fourteenth centuries. Far from marking the triumph of toleration, he argued, the alliance of Christian kings and Muslim soldiers depended on and reproduced ideas of religious difference.The Mercenary Mediterraneanreceived theHerbert Baxter Adams Prizefrom the American Historical Association for the best first book in European history, the L. Carl Brown Prize from the American Institute of Maghreb Studies for the best book in North African studies, and the Jans F. Verbruggen Prize fromDe Re Militarifor the best book in medieval military history. Most recently, along with Alejandro García-Sanjuán, he editedWhat Was the Islamic Conquest of Iberia?, a collection that examined the on-going scholarly controversies surrounding the Islamic conquest of the Iberian Peninsula in 711.He is currently working on two projects. The first, entitledThe Impostor Sea: The Making of the Medieval Mediterranean, follows the activities of criminal merchants—pirates and smugglers—to rethink the relationship between religion and trade. Rather than “enemies of all,” this book argues that these figures were central to the making of new legal, religious, and racial boundaries in the late medieval Mediterranean. The second, entitledThe Eastern Question, examines western views of Islam from the seventh century to the present, arguing that both positive and negative images of Islam across history share the same polemical genealogy.Fancy received his B.A. in English from Yale University and a Ph.D. in History from Princeton University, where he studied with William Chester Jordan and Michael Cook.  Before coming to Yale, he taught at the University of Michigan for eleven years.  Fancy was a Junior Fellow of the Michigan Society of Fellows, a Carnegie Scholar, an ACLS Fellow, and a Rome Prize Fellow of the American Academy in Rome.  He has served as a Councillor of the Medieval Academy of America and as a board member of the American Institute of Maghreb Studies and the Spain and North Africa Project.  He has also lived and worked extensively in Spain, Italy, France, and across North Africa.Professor Fancy welcomes inquiries from prospective graduate students interested in any aspect of Medieval European and/or Islamic History, particularly comparative study.Selected Publications:The Mercenary Mediterranean: Sovereignty, Religion, and Violence in the Medieval Crown of Aragon(University of Chicago Press, 2016; 2nded. 2018) *Winner of the Herbert Baxter Adams Prize, the L. Carl Brown Prize, and the Jans F. Verbruggen Prize.*What was the Islamic Conquest of Iberia? Understanding the Debate, ed. with Alejandro García Sanjuán (New York: Routledge, 2021)“Provincializing the Mediterranean”in “On Transnational and International History,”The American Historical Review, 128, no. 1 (2023): 255-332.“Color, Race, and Religion in theCantigas de Santa Maria”inBalthazar: A Black African King in Medieval and Renaissance Art, eds. Kristen Collins and Bryan Keene (Los Angeles: Getty Publications, 2023), 42-47.with M. Cooperson, M. Karnes, et. al.,“Fictionalities in medieval Arabic texts: A roundtable,”Postmedieval13 (2022): 577-592.“Convivencia and Crisis,”History and Anthropology32, no. 5 (2021): 647-51.“Captivity, Ransom, and Manumission”inThe Cambridge World History of Slavery: AD 500 - AD 1420, eds. David Richardson, Stanley Engerman, David Eltis and Craig Perry, vol. 2 (Cambridge University Press, 2021), 53-76.“The New Convivencia,”Journal of Medieval Iberian Studies, 11, no. 3 (2019): 295-305.“Muslim Crusaders: Guzmán el Bueno and the Limits of Secular History,”in “Voices of Conflict and Cultural Difference in the Medieval Mediterranean,” ed. Michael Lower and Uri Shachar, a themed issue ofal-Masaq30, no. 3 (2018): 248-265.“Of Sovereigns, Sacred Kings, and Polemics,”History and Theory36, no. 1 (2017): 61-70.“Monarchs and Minorities: ‘Infidel’ Soldiers in Mediterranean Courts,” inThe Globalization of Knowledge in the Post-Antique Mediterranean, ed. Jürgen Renn and Sonja Brentjes (Routledge, 2016).“Theologies of Violence: The Recruitment of Muslim Soldiers by the Crown of Aragon,”inPast & Present221, no. 1 (Nov. 2013) *Winner of the Bishko Prize for best article published in the field of medieval Iberian history.*“The Last Almohads: Universal Sovereignty between North Africa and the Crown of Aragon,”in Medieval Encounters 19:1-2 (2013). [Reprinted in Spanning the Strait: Studies in Unity in the Western Mediterranean, ed. Yuen-Gen Liang, Abigail Krasner Balbale, Andrew Devereux, and Camillo Gómez-Rivas (Brill, 2013).“The Intimacy of Exception: The Diagnosis of Samuel Abenmenassé,”in Center and Periphery: Studies on Power in the Medieval World in Honor of William Chester Jordan, ed. Katherine L. Jansen, G. Geltner, and Anne E. Lester (Brill, 2013)." + }, + { + "name": "Paul Freedman", + "department": "History", + "profile_url": "https://history.yale.edu/people/paul-freedman", + "fields_of_interest": "Medieval European history", + "bio": "Professor Freedman specializes in medieval social history, the history of Catalonia, comparative studies of the peasantry, trade in luxury products, and the history of cuisine.  His latest books are TheSplendor and Opulence of the Past: Studying the Middle Ages in Enlightenment Catalonia(Cornell University Press, 2023) and (co-authored with Marc Aronson)Bite by Bite: American History through Feasts, Food, and Side Dishes(Simon & Schuster, 2024).\n\nFreedman earned his BA at the University of California at Santa Cruz and an MLS from the School of Library and Information Studies at the University of California at Berkeley. He received a Ph.D. in History at Berkeley in 1978. His doctoral work focused on medieval Catalonia and how\n\nthe bishop and canons interacted with the powerful and weak elements of lay society in Vic, north of Barcelona. This resulted in the publication ofThe Diocese of Vic: Tradition and Regeneration in Medieval Catalonia(1983).\n\nFreedman taught for eighteen years at Vanderbilt University before joining the Yale faculty in 1997. At Vanderbilt, he focused on the history of Catalan peasantry, papal correspondence with Catalonia and a comparative history of European seigneurial regimes. He was awarded Vanderbilt’s Nordhaus Teaching Prize in 1989 and was the Robert Penn Warren Humanities Center Fellow there in 1991-1992. During that time, he published his second book,Origins of Peasant Servitude in Medieval Catalonia(1991).\n\nSince coming to Yale, Professor Freedman has served as Director of Undergraduate Studies in History, Director of theMedieval Studies Program, Chair of the History Department, and Chair of the Program in the History of Science and Medicine He has offered graduate seminars on the social history of the Middle Ages, church, society and politics, and agrarian studies (as part of a team-taught course).\n\nFreedman was a visiting fellow at the Max-Planck-Institut für Geschichte in Göttingen in 2000 and Directeur d’Études Associé at the École des Hautes Études en Sciences Sociales in Paris in 1995. His third book wasImages of the Medieval Peasant(1999) and there are two collections of his essays:Church, Law and Society in Catalonia, 900-1500andAssaigs d’historia de la pagesia catalana( “Essays on the History of the Catalan Peasantry,” translated into Catalan).\n\nFreedman editedFood: The History of Taste, an illustrated collection of essays about food from prehistoric to contemporary times published by Thames & Hudson (London) and in the US by the University of California Press (2007).  His book on the demand for spices in medieval Europe was published in 2008 by Yale University Press.  It is entitledOut of the East: Spices and the Medieval Imagination.  In the field of culinary history, he publishedTen Restaurants That Changed Americain 2016 (Liveright/Norton). A book for Yale University Press entitledWhy Food Mattersappeared in 2021. This short manifesto describes why food is important, not just for biological survival, but for reasons of cultural identity, memory, and orientation in the world.  His study of Catalan attitudes toward its medieval history is the theme ofThe Splendor and Opulence of the Past(2023) which is centered on a group of clerics in the eighteenth century who wanted to rescue the memory of Catalonia’s past during the period of Spanish, Bourbon hegemony, and also advocated a program of modernization of the Catalan economy that would lead Spain into closer relations to the European culture of secular progress,Bite by Biteis a book for children ten and up, but also an introduction to American history through specific historical meals and venues such as soda fountains, Italian restaurant and Native American celebrations that show the range of creativity as well as conflict over many centuries.\n\nFreedman also co-edited three other collections: with Caroline Walker Bynum,Last Things: Death and the Apocalypse in the Middle Ages(1999)  with Monique Bourin,Forms of Servitude in Northern and Central Europe(2005), and with Ken Albala and Joyce Chaplin,Food in Time and Place(2014).\n\nA Fellow of the Medieval Academy of America, Freedman is also a corresponding fellow of the Real Academia de Buenas Letras de Barcelona and of the Institut d’Estudis Catalans.  He is a member of the American Philosophical Society and the American Academy of Arts and Sciences. His honors include the 2024 publication award from the North American Catalan Society forThe Splendor and Opulence of the Past,a 2008 cookbook award (reference and technical) from the International Association of Culinary Professionals (forFood: The History of Taste) and three awards forImages of the Medieval Peasant: the Haskins Medal of the Medieval Academy (2002), the 2001 Otto Gründler prize given by the Medieval Institute at Western Michigan University in Kalamazoo, and the Eugene Kayden Award in the Humanities given by the University of Colorado. He won the American Historical Association’s Premio del Rey Prize in 1992 (forThe Origins of Peasant Servitude in Medieval Catalonia) and shared the Medieval Academy’s Van Courtlandt Elliott prize for the best first article on a medieval topic in 1981." + }, + { + "name": "Joanne Freeman", + "department": "History", + "profile_url": "https://history.yale.edu/people/joanne-freeman", + "fields_of_interest": "Revolutionary & Early National American history with special interest in politics & culture; Early American journalism & print culture", + "bio": "Joanne B. Freeman, Professor of History, specializes in the politics and political culture of the revolutionary and early national periods of American History.  She earned her Ph.D. at the University of Virginia.  Her most recent book,Affairs of Honor: National Politics in the New Republic(Yale University Press), won the Best Book award from the Society of Historians of the Early American Republic, and her edited volume,Alexander Hamilton: Writings(Library of America) was one of theAtlantic Monthly’s“best books” of 2001.  Her current project,The Field of Blood: Congressional Violence in Antebellum America, explores physical violence in the U.S. Congress between 1830 and the Civil War, and what it suggests about the institution of Congress, the nature of American sectionalism, the challenges of a young nation’s developing democracy, and the longstanding roots of the Civil War.A fellow of the Society of American Historians, Freeman has won fellowships from, among others, the American Council of Learned Societies, the Cullman Center for Scholars and Writers, the Dirkson Congressional Research Center, the American Historical Association, and the Library of Congress.  She is a Distinguished Lecturer for the Organization of American Historians, and was rated one of the nation’s “Top Young Historians” in 2005.Freeman’s articles have appeared in a wide range of academic journals includingWilliam and Mary Quarterly,Journal of the Early Republic,Journal of Policy History, andYale Law Journal, among others.  She has written op-ed pieces for theNew York Times, and appeared in a host of documentaries on PBS and the History Channel, and in a number of radio programs for NPR and the BBC.  She has done extensive work in the realm of public history, including co-curating museum exhibitions, acting as a historical consultant for documentary filmmakers, and giving frequent public lectures at venues such as the Smithsonian Museum of American History, the National Gallery of Art, and Colonial Williamsburg, among other places. She has also worked extensively with high school history teachers and students in workshops, lectures, and symposia around the nation.  In the last two years, she has worked as a historical consultant for the National Park Service in the reconstruction of the Alexander Hamilton Grange National Memorial.Freeman teaches graduate reading and research courses in early national American history, and undergraduate seminars on early national politics and political culture, as well as lecture courses on the American Revolution and early national America." + }, + { + "name": "John Gaddis", + "department": "History", + "profile_url": "https://history.yale.edu/people/john-gaddis", + "fields_of_interest": "Cold War history; Historical methodology; Biography; Grand Strategy", + "bio": "John Lewis Gaddis is Robert A. Lovett Professor of Military and Naval History at Yale University, where he teaches courses on the Cold War, grand strategy, biography, historical methods, and time travel.His most recent books includeThe Landscape of History:  How Historians Map the Past(2002),Surprise, Security, and the American Experience(2004),The Cold War:  A New History(2005), a new edition ofStrategies of Containment:  A Critical Appraisal of Postwar American National Security Policy(2005),George F. Kennan:  An American Life(2011), andOn Grand Strategy(2018).He’s currently writing a microhistory of the small Texas town in which he grew up.Professor Gaddis has received two awards for undergraduate teaching at Yale, as well as the National Humanities Medal and the 2012 Pulitzer Prize for biography." + }, + { + "name": "Beverly Gage", + "department": "History", + "profile_url": "https://history.yale.edu/people/beverly-gage", + "fields_of_interest": "Gilded Age and 20th century; political history; government and political development; ideology and social movements (esp. conservatism and radicalism)", + "bio": "Beverly Gage is the John Lewis Gaddis Professor of History. Her courses focus on 20th-century U.S. history.Her new book,This Land is Your Land: A Road Trip through U.S. History,will be published by Simon & Schuster in April 2026. The book offers an on-the-road, behind-the-steering-wheel retelling of 250 years of U.S. history, starting at Philadelphia’s Revolution-era historic sites and ending at Disneyland in the 20th-century California dream. On the occasion of the 250th anniversary of the Declaration of Independence, it makes the case for exploring–and reckoning with–all 250 years of American national history. It also has some fun along the way.She is currently at work on a biography of Ronald Reagan, with an emphasis on the ways that debates over communism and the Cold War shaped his life and politics.Her bookG-Man: J. Edgar Hoover and the Making of the American Century, a biography of former FBI director J. Edgar Hoover, received the 2023 Pulitzer Prize for Biography, the Bancroft Prize in American History and Diplomacy, the National Book Critics Circle Award for Biography, theLos Angeles TimesBook Prize in Biography, the Barbara and David Zalaznick Book Prize in American History, and the Ellis W. Hawley Prize of the Organization of American Historians.G-Manwas named a best book of 2022 by theWashington Post,The Atlantic,Publishers Weekly,The New Yorker,The New York Times, andSmithsonian.Professor Gage is also the author ofThe Day Wall Street Exploded: A Story of America in its First Age of Terror, which examined the history of terrorism in the late 19th and early 20th centuries, focusing on the 1920 Wall Street bombing. In addition to her teaching and research, she writes for numerous journals and magazines, includingThe New Yorker,New York Times, andWashington Post.In 2009, Professor Gage received the Sarai Ribicoff Award for teaching excellence in Yale College. In 2015, she was elected to serve as the first chair of Yale’s Faculty of Arts and Sciences Senate. From 2017 to 2021, she served as director of Yale’s Brady-Johnson Program in Grand Strategy.With Professor Elizabeth Hinton, Professor Gage leads theWorkshop in Modern U.S. History, a monthly speaker series for faculty and graduate students to discuss the latest scholarship in 20th-century U.S. history.Professor Gage is a graduate of Yale University (1994, BA, American Studies) and Columbia University (2004, PhD, History)." + }, + { + "name": "Joe Glynias", + "department": "History", + "profile_url": "https://history.yale.edu/people/joe-glynias", + "fields_of_interest": "", + "bio": "Dr. Joe Glynias works and teaches at the intersection of Islamic, Byzantine, and Eastern Christian history in the late antique and medieval Mediterranean and Middle East. In particular, he focuses on the cultural transmission of texts and ideas, the agents of transmission, and the historical moments in which these actions occurred. Prior to Yale, Dr. Glynias was Junior Fellow at the Harvard Society of Fellows (2022-2025).Glynias’s first book, contracted with Princeton University Press, considers the massive translation movement undertaken in Byzantine Antioch in the 10th and 11th centuries, in which hundreds of Greek Christian texts were translated into Syriac and Arabic. He is also working on two additional monograph-length projects: the first considers the canonization of Christian Arabic canon law in the 12th century by multilingual Christians living under Muslim rule who were influenced by the developing Byzantine legal tradition. The second, longer-term project is concerned with the translation from Arabic to Greek of the Arabic philosophical and scientific traditions that had developed as a result of the Greco-Arabic translation movement in Abbasid Baghdad.Glynias’s work has been supported by a number of fellowships including a Junior Fellowship at Dumbarton Oaks and a Dodds Fellowship at Princeton. He has published on a wide range of topics including Byzantine monasticism, Greco-Arabic translation, Arabo-Greek astrology, Syriac manuscripts, Byzantine sigillography, and Islamic coinage." + }, + { + "name": "Greg Grandin", + "department": "History", + "profile_url": "https://history.yale.edu/people/greg-grandin", + "fields_of_interest": "", + "bio": "Greg Grandin, who received his doctorate at Yale University under the direction of Emilia Viotti da Costa and Gilbert Joseph, previously taught at New York University for nineteen years.  He is the author of seven books, includingThe Blood of Guatemala,which won the Latin American Studies Association’s Bryce Wood Award for best book published on Latin America in any discipline,The Last Colonial Massacre, Empire’s Workshop, Fordlandia,which was a finalist for the Pulitzer Prize, the National Book Award, and the National Book Critics Award,The Empire of Necessity,which won the Bancroft and Beveridge awards in American history,Kissinger’s Shadow,andThe End of the Myth,which won the Pulitzer Prize for general non-fiction and was a finalist in the history category.  Grandin is a member of the American Academy of Arts and Sciences and the Society of American Historians.  He has co-edited, with Gil Joseph,A Century of Revolution,and, with Deborah Levenson and Elizabeth Oglesby,The Guatemala Reader.  Grandin has published widely, inThe Nation,where he is a member of the editorial board,theLondon Review of Books,theNew Republic,NACLA’sReport on the Americas,and theNew York Times,among other venues.  He is a regular guest onDemocracy Now!A revised edition ofEmpire’s Workshopis forthcoming." + }, + { + "name": "Valerie Hansen", + "department": "History", + "profile_url": "https://history.yale.edu/people/valerie-hansen", + "fields_of_interest": "China to 1600; Chinese religious & legal history; History of the Silk Road", + "bio": "“The Kitan-Liao and Jurchen-Jin,”in Victor Cunrui Xiong and Kenneth J. Hammond, ed.,The Routledge Handbook to Imperial Chinese History. New York: Routledge, 2019, pp. 213-228." + }, + { + "name": "Robert Harms", + "department": "History", + "profile_url": "https://history.yale.edu/people/robert-harms", + "fields_of_interest": "Sub-Saharan Africa", + "bio": "Robert Harms received his Ph.D. from the University of Wisconsin-Madison in 1978.  He is the author of River of Wealth, River of Sorrow: The Central Zaire Basin in the Era of the Slave and Ivory Trade (1981), Games Against Nature: An Eco-Cultural History of the Nunu of Equatorial Africa (1988/1999), The Diligent: A Voyage through the Worlds of the Slave Trade (2002), Africa in Global History (2018), and Land of Tears: The Exploration and Exploitation of Equatorial Africa (2019).  His graduate courses include seminars on African environmental history, African agrarian history, colonialism in Africa, and decolonization.\n\nProfessor Harms’ celebrated book The Diligent: A Voyage through the Worlds of the Slave Trade, is based on the extraordinary journal of French lieutenant Robert Durand, who participated in the slave trade.  Clickhereto watch a short TV news report about Professor Harms’ research. Then look at the sample entry from Lieutenant Durand’s journal below, which is located in Yale’s Beinecke Rare Books and Manuscripts Library." + }, + { + "name": "Elizabeth Hinton", + "department": "History", + "profile_url": "https://history.yale.edu/people/elizabeth-hinton", + "fields_of_interest": "20th Century United States History; political history; urban history; African American studies; criminalization; policing; incarceration.", + "bio": "Elizabeth Hinton is Professor of History, Black Studies, and Law. Her research focuses on the persistence of poverty, racial inequality, and urban violence in the 20th century United States.Professor Hinton’s first book,From the War on Poverty to the War on Crime: The Making of Mass Incarceration in America(Harvard University Press), examines the implementation of federal law enforcement programs beginning in the mid-1960s that transformed domestic social policies, expanded policing in low-income communities, and facilitated the dramatic expansion of the U.S. prison system. From the War on Poverty to the War on Crime received numerous awards and recognition, including the Ralph Waldo Emerson Award from the Phi Beta Kappa Society. Her recent book,America on Fire: The Untold History of Police Violence and Black Rebellion Since the 1960s(Liveright 2021), won a Robert F. Kennedy book award. America on Fire provides a new framework for understanding the problem of police abuse and the broader, systemic repression of Black people and other people of color in post-civil rights America.From the War on Poverty to the War on CrimeandAmerica on Firewere both named New York Times Notable books.Professor Hinton’s articles and op-eds can be found in the pages ofScience, Nature, The American Historical Review, The Journal of American History, The Journal of Urban History, The New York Times, The Washington Post, The Atlantic, New York Magazine, The Boston Review, The Nation, andTime. With the late historian Manning Marable, she coeditedThe New Black History: Revisiting the Second Reconstruction(Palgrave Macmillan 2011). Professor Hinton served as a member of the National Academies of Sciences Committee on Reducing Racial Inequalities in the Criminal Justice System and was elected to the American Philosophical Society in 2022.With Professor Beverly Gage, Professor Hinton leads the Workshop in Modern U.S. History, a monthly speaker series for faculty and graduate students to discuss the latest scholarship in 20th-century U.S. history.Before joining the Yale faculty, Hinton was a professor in the Department of History and the Department of African and African American Studies at Harvard University, where she continues to serve as founding co-director of the Institute on Policing, Incarceration, and Public Safety at the Hutchins Center for African & African American Research. She spent two years as a Postdoctoral Scholar in the Michigan Society of Fellows and Assistant Professor in the Department of Afroamerican and African Studies at the University of Michigan. A Ford Foundation and Carnegie Corporation Fellow, Hinton completed her Ph.D. in United States History from Columbia University in 2013." + }, + { + "name": "Matthew Jacobson", + "department": "History", + "profile_url": "https://history.yale.edu/people/matthew-jacobson", + "fields_of_interest": "US cultural history; 19th & 20th century immigration, ethnicity & race; US expansionism", + "bio": "Matthew Frye Jacobson is Sterling Professor of American Studies and History. He is the author of eight books on race, politics, and culture in the United States:Dancing Down the Barricades:  Sammy Davis, Jr. and the Long Civil Rights Era(2023);Odetta’s One Grain of Sand(2019);The Historian’s Eye:  Photography, History, and the American Present(2018);What Have they Built You to Do?: The Manchurian Candidate and Cold War America, (with Gaspar Gonzalez, 2006);Roots Too: White Ethnic Revival in Post–Civil Rights America(2005);Barbarian Virtues: The United States Encounters Foreign Peoples at Home and Abroad, 1876–1917(2000);Whiteness of a Different Color: European Immigrants and the Alchemy of Race(1998); andSpecial Sorrows: The Diasporic Imagination of Irish, Polish, and Jewish Immigrants in the United States(1995).  He also served as creator, writer, and lead researcher forA Long Way from Home:  The Untold Story of Baseball’s Desegregation(Hammer & Nail Productions, 2019).  The film garnered a Golden Telly Award in the category of General Television Documentary (2019).  Ongoing projects includeDick Gregory and the Idea of Political Comedy.Along with Patty Limerick, he has also hostedHistorians Imagine,a monthly webinar devoted to creativity in the historian’s craft.His teaching and research focus on race in U.S. political culture 1790–present, including U.S. imperialism, immigration and migration, popular culture, Civil Rights, and the juridical structures of U.S. citizenship, in addition to Documentary Studies and Public Humanities." + }, + { + "name": "Destin Jenkins", + "department": "History", + "profile_url": "https://history.yale.edu/people/destin-jenkins", + "fields_of_interest": "Modern U.S.; African American Studies; Political Economy; Racial Capitalism; Urban History; Crime", + "bio": "Destin Jenkins is an associate professor of History and Black Studies at Yale University. His research focuses on the political economy of capitalism, the inequality of life chances, and the efforts of Black people to thrive and survive even when that created conflicts within “the Black community.”His first book,The Bonds of Inequality: Debt and the Making of the American City(University of Chicago Press, 2021), was widely reviewed and won the Ellis W. Hawley Prize and James A. Rawley Prize from the Organization of American Historians (2022), the 2022 Kenneth Jackson Award for Best Book in North American Urban History, and was a finalist for the Hagley Prize in Business History (2023), and the 2022 best new book in African American History and Culture from the Association for the Study of African American Life and History.He is also co-editor ofHistories of Racial Capitalism(Columbia University Press, 2021). His articles have appeared in theAmerican Historical Review, theJournal of Urban History, theWashington Post, The Nation, theNew York Times, and elsewhere.Jenkins is currently working on two books. The first excavates pivotal episodes in the politicization of debt in America from its emergence as a post-colonial nation through the concurrent end of the Cold War and war on crime. This book will appear with W.W. Norton. The second project weaves together two intersecting stories, the rise of Black political power and the political economy and emotions of crime in the wake of the civil rights revolution.Beyond these book projects, he is co-convener of the Endeavors Seminar Series (2025-26) in the Department of Black Studies. Jenkins will soon launch two major initiatives, the Debt Lab and the Research Program on Black Political Economy.Jenkins received his BA from Columbia University and his Ph.D. in Modern U.S. History from Stanford University. He has held fellowships at Harvard University, The New School and Stanford University, and his work has been generously supported by the Robert Wood Johnson Foundation.Before arriving at Yale, he was the Neubauer Family Assistant Professor of History at the University of Chicago and earned tenure at Stanford University.Professor Jenkins welcomes inquiries from prospective graduate and undergraduate students interested in the history of capitalism, racial inequality, and urban democracy.Photo credit: Jermaine Jackson, Jr." + }, + { + "name": "Paul Kennedy", + "department": "History", + "profile_url": "https://history.yale.edu/people/paul-kennedy", + "fields_of_interest": "Great power relations, 19th & 20th centuries; Military & naval history; British foreign & imperial history; Contemporary global security issues; United Nations history", + "bio": "Paul Kennedy, the J. Richardson Dilworth Professor of History, Director of International Security Studies at Yale, and Distinguished Fellow of the Brady-Johnson Program in Grand Strategy, coordinates the ISS programs funded by the Smith Richardson Foundation. He is internationally known for his writings and commentaries on global political, economic, and strategic issues.\n\nBorn in June 1945 in the northern English town of Wallsend, Northumberland, he obtained his BA at Newcastle University and his DPhil at the University of Oxford. He is a former Fellow of the Institute for Advanced Studies, Princeton University, and of the Alexander von Humboldt-Stiftung, Bonn. He holds many honorary degrees, and is a Fellow of the Royal Historical Society, the American Philosophical Society, and the American Academy of Arts and Sciences. He was made Commander of the Order of the British Empire (C.B.E.) in 2000 for services to History and elected a Fellow of the British Academy in June 2003.\n\nProf. Kennedy’s monthly column on current global issues is distributed worldwide by the Los Angeles Times Syndicate/Tribune Media Services. He is the author or editor of nineteen books, includingThe Rise of the Anglo-German Antagonism, The War Plans of the Great Powers, The Realities Behind Diplomacy,andPreparing for the Twenty-First Century. His best-known work isThe Rise and Fall of the Great Powers, which provoked an intense debate on its publication in 1988 and has been translated into over twenty languages.\n\nIn 1991, he edited a collection entitledGrand Strategies in War and Peace. He helped draft the Ford Foundation-sponsored report issued in 1995,The United Nations in Its Second Half-Century, which was prepared for the fiftieth anniversary of the UN. His 2006 bookThe Parliament of Mencontemplates the past and future of the United Nations. Prof. Kennedy’s most recent bookEngineers of Victory, history through the eyes of problem-solvers during the Second World War, was published in 2013. He is currently writing a book about seapower and global transformations during World War Two." + }, + { + "name": "Jennifer Klein", + "department": "History", + "profile_url": "https://history.yale.edu/people/jennifer-klein", + "fields_of_interest": "20th century US history; Urban history; Labor history; 20th Century political economy and policy", + "bio": "Jennifer Klein is Durfee Professor of History in the field of 20th Century US history. She earned her B.A. at Barnard College, her Ph.D. at the University of Virginia and first came to Yale as a Robert Wood Johnson Foundation fellow in Health Policy.\n\nKlein was the winner of the 2014 Hans Sigrist Prize awarded by the University of Bern (Switzerland) and the Hans Sigrist Foundation for her contribution to the field of “Women and Precarity: Historical Perspectives.”Read the full news item here.Klein has been selected as a Visiting Scholar at the Russell Sage Foundation for 2022-23.\n\nProfessor Klein’s research spans the fields of U.S. labor history, urban history, social movements and political economy.  Her publications includeCaring for America: Home Health Workers in the Shadow of the Welfare State(Oxford, 2012), co-authored with Eileen Boris, which was awarded the Sara A. Whaley book prize from the National Women’s Studies Association; andFor All These Rights: Business, Labor, and the Shaping of America’s Public-Private Welfare State(Princeton, 2003)which was awarded the Ellis W. Hawley Prize in Political History/Political Economy from the Organization of American Historians and The Hagley Prize in Business History from the Business History Conference. Writing about the intersection between labor politics and the welfare state, she has written articles on the history of health care policy, Social Security, pensions, collective bargaining and New Deal liberalism, including “The Politics of Economic Security: Employee Benefits and the Privatization of New Deal Liberalism,”published in theJournal of Policy History.\n\nKlein’s current research project is “Wastelands: The Economic Geography of Waste, Coercion, and Marginalization in Southeastern Louisiana, 1790-1990s.”\n\nA labor history of home health care workers from the 1930s to the present,Caring for America: Home Health Workers in the Shadow of the Welfare State(Oxford University Press, 2012) co-authored with Eileen Boris, explores the links between public welfare, health care, social movements and employment law.  Their articles on home care workers, long term care and labor organizing include:“Organizing Home Care: Low-Waged Workers in the Welfare State”inPolitics and Society(March 2006); “We Were the Invisible Workforce: Unionizing Home Care” inThe Sex of Class: Women Transforming American Labor, ed. Dorothy Sue Cobble (ILR/Cornell Press, 2007),“Laws of Care: The Supreme Court and Aides to Elderly People”inDissent(Fall 2007),“Organizing the Carework Economy: When the Private Becomes Public,” inRethinking U.S. Labor History: Essays in the Working-Class Experience, 1756-2009, Donna Haverty-Stacke and Daniel Walkowitz, eds. (Continuum,  2010),“Frontline Caregivers: Still Struggling”inDissent(Winter 2012) and“Home Care Workers Aren’t Just Companions,”New York Times, July 2, 2012.  Her recently published article,“Innoculations: The Social Politics of Time, Labor, and the Public Good in COVID America,”appeared in ILWCH (Spring 2021).  Klein’s article,“Between Home and State:  Careworkers and Labor Strategy for the New Open-Shop Era of Trumplandia”, is published in the book, Labor in the Era of Trump, ILR Press.\n\nShe serves on the board of the journalInternational Labor and Working Class History.She edited a special issue ofILWCH,The Class Politics of Privitization: Global Perspectives on the Privitization of Public Workers, Land, and ServicesNo. 71 (Spring 2007).\n\nIn addition to academic publications, her articles on labor, low-wage work, care, and social policy have appeared inDissent, The New York Times, The Nation.com, WashingtonPost.com, American Prospect (TAP.org), New Labor Forum, Labor Notes, CNN.comandDemocracy.\n\nKlein teaches courses in history of labor, class, and capitalism;  20th century political economy; U.S. urban history; U.S. women’s history; and contemporary America, 1940-Present. She has advised prize-winning dissertations in labor history; policy, the welfare state, and international social security politics; post-WWI political culture and social movements; and political economy and capitalism." + }, + { + "name": "Regina Kunzel", + "department": "History", + "profile_url": "https://history.yale.edu/people/regina-kunzel", + "fields_of_interest": "20th-century U.S.; histories of gender and sexuality; incarceration; psychiatry; disability", + "bio": "Regina Kunzel, Larned Professor of History and Professor of Women’s, Gender, and Sexuality Studies, is an historian of the modern United States with interests in histories of gender and sexuality, queer history, the history of psychiatry, and the history of incarceration.Kunzel’s most recent book,In the Shadow of Diagnosis: Psychiatric Power and Queer Life(University of Chicago, 2024), explores the encounter of queer and gender-variant people with psychiatry in the 20-century US.  Kunzel’s bookCriminal Intimacy: Prison and the Uneven History of Modern American Sexuality(University of Chicago Press, 2008), was awarded the American Historical Association’s John Boswell Prize, the Modern Language Association’s Alan Bray Memorial Book Award, the Lambda Literary Award, the Foundation for the Scientific Study of Sexuality’s Bonnie and Vern L. Bullough Award, and was a finalist for the American Studies Association’s John Hope Franklin Prize.  Kunzel is also the author ofFallen Women, Problem Girls: Unmarried Mothers and the Professionalization of Social Work, 1890 to 1945(Yale University Press, 1993).Kunzel received her BA from Stanford University and PhD from Yale. She previously taught at Williams College, the University of Minnesota, and Princeton University.  Kunzel has been awarded fellowships from the American Council of Learned Societies, the Radcliffe Institute for Advanced Study, and the Social Science Research Council, and is an elected member of the Society of American Historians.Recent publications:In the Shadow of Diagnosis: Psychiatric Power and Queer Life(University of Chicago Press, 2024)“Sex Panic, Psychiatry, and the Expansion of the Carceral State,” inIntimate States: Gender, Sexuality and Governance in Modern U.S. History, eds. Margot Canaday, Nancy F. Cott, and Robert O. Self (Chicago: University of Chicago Press, 2021)“The Power of Queer History,”American Historical Review123:5 (December 2018): 1560-1582“The Rise of Gay Rights and the Disavowal of Disability,” inThe Oxford Handbook of Disability History, eds. Michael A. Rembis, Catherine J. Kudlick, Kim Nielsen (New York and London: Oxford University Press, 2018): 459-476“The Uneven History of Modern American Sexuality,”Modern American History1:1 (Spring 2018): 97-100“Queer History, Mad History, and the Politics of Health,”American Quarterly69:2 (June 2017): 315-19“Lessons in Being Gay: Queer Encounters in Gay and Lesbian Prison Activism,”Queer Futures, special issue ofRadical History ReviewNo. 100 (Winter 2008): 11-37" + }, + { + "name": "Noel Lenski", + "department": "History", + "profile_url": "https://history.yale.edu/people/noel-lenski", + "fields_of_interest": "", + "bio": "Lenski focuses on Roman history and particularly the history of the later Roman Empire. He is interested in power relations as these played themselves out at all levels of society, from emperors to slaves. His research ranges broadly across Late Antiquity and includes studies in political, military, social, economic, religious, cultural and art history. His two monographs, on the emperors Valens and Constantine, explore the limits of imperial power in light of reader response theory and life-worlds theory. He has also published extensively on the history of slavery in antiquity and is currently working on monographs on slavery in Late Antiquity and another on the global history of slavery in premodernity. His study of ancient law will soon result in a co-authored translation and commentary of theLiber IudiciorumorLaws of the Visigoths,to appear with Liverpool University Press. And he is also working on a monograph on human migration in the late Roman period.Recent Articles“Germanic Law and the Practice of Slaveholding in the Post-Roman West,” in M. Schermaier, J. Winnebeck, and M. Becher, eds.Norms of Dependency in Late Antique and Early Medieval Societies(Berlin 2025), 91-127https://uplopen.com/chapters/e/10.1515/9783111661438-006“The Late Roman Colonate – A New Status between Slave and Free,” in S. Hodkinson, M. Kleijwegt, and K. Vlassopoulos (eds.)Oxford Handbook of Greek and Roman Slaveries(Oxford 2022) C24.P1–C24.S8,https://doi.org/10.1093/oxfordhb/9780199575251.013.24“Moving the Mail: The Status and Operations of Letter Carriers in the Collectio Avellana,” in R. Lizzi Testa, G. Marcone, and A. Giomma, eds.The Collectio Avellana and the Development of Notarial Practices in Late Antiquity, GIFBIB, 31 (Turnhout 2023) 507-63.“Law and Language in the Roman and Germanic Traditions: A Study of Liber Iudiciorum 6.4.3 and the Idea ofiniuriain Visigothic Law”, in Carlo Lorenzi and Marialuisa Navarro, eds.Atti dell’Accademia Romanistica Costantiniana, 25, La costruzione del testo giuridico tardoantico(2023), 355-427.“Slavery in the Roman Empire”, in Damian Pargas and Julianne Schiel, eds.The Palgrave Handbook of Global Slavery Throughout History(Palgrave 2023) 87-107 -https://link.springer.com/chapter/10.1007/978-3-031-13260-5_5“New Paths to Power: The Bipartite Division of Italy and Its Realignment of Society and Economy in Fourth-Century Italy”, in J. Wijnendaele, ed.A Companion to Late Roman Italy(Edinburgh 2023) 35-66.Books EditedFrom East to West in Late Antiquity: Studies in honor of Jan Willem Drijvers.Munera, Studi storici sulla Tarda Antichità56 (Edipugila 2024) (co-edited with Roger Rees and Onno van Nijf)The Fifth Century: Age of Transformation. Proceedings of the 12thBiennial Shifting Frontiers in Late Antiquity Conference.Munera, Studi storici sulla Tarda Antichità46 (Edipuglia 2019)The Cambridge Companion to the Age of Constantine(Cambridge University Press 2006; revised edition 2011)The Power of Religion in Late Antiquity(Ashgate Press, 2009) (with Andrew Cain)Costantino prima e dopo Costantino — Constantine before and after Constantine(Edipuglia, 2012) (with G. Bonamente and R. Lizzi Testa)What is a Slave Society? The Practice of Slavery in Global Perspective(Cambridge University Press 2018) (co-edited with Catherine M. Cameron)" + }, + { + "name": "Mary Lui", + "department": "History", + "profile_url": "https://history.yale.edu/people/mary-lui", + "fields_of_interest": "Asian American history; US urban history; Race & ethnicity; Immigration, gender and sexuality", + "bio": "Mary Lui is Professor of American Studies and History. Her primary research interests include: Asian American history, urban history, women and gender studies, and public history. She is the author ofThe Chinatown Trunk Mystery: Murder, Miscegenation, and Other Dangerous Encounters in Turn-of-the-Century New York City(Princeton University Press, 2005). The book uses a 1909 unsolved murder case to examine race, gender, and interracial sexual relations in the cultural, social and spatial formation of New York City Chinatown from 1870-1920." + }, + { + "name": "Benedito Machava", + "department": "History", + "profile_url": "https://history.yale.edu/people/benedito-machava", + "fields_of_interest": "Colonial and Post-colonial Africa, Liberation Struggles, Decolonization, African Socialism, Carcerality, Culture and Politics in Lusophone Africa", + "bio": "Benedito Machava is a historian of colonial and post-colonial Africa. Raised and educated in Mozambique, he received his PhD at Michigan University in 2018. His research focuses on liberation struggles, decolonization, nation building, socialism and socialist experiments in Africa. His current book manuscript,The Morality of Revolution:Reeducation Camps and the Carceral Regime in Socialist Mozambique, 1974-1990,examines the politics of public morality, carcerality/punishment and citizenship in post-independence Mozambique. His research has been supported by fellowships from the Social Science Research Council, the Guggenheim Foundation, among others. Before coming to Yale, Machava was a Cotsen-Link Postdoctoral Fellow in the Society of Fellows at Princeton University (2018-2020) and a History Lecturer at University Eduardo Mondlane in Maputo, Mozambique.Selected Publications:“Reeducation Camps, Austerity, and the Carceral Regime in Socialist Mozambique (1974-79),Journal of African History,60, 3 (2019): 429-455“The Dead Archive: Notes on Institutional Memories and the State in Mozambique” (with Euclides Gonçalves),Africa(under review)“Reeducation Camps and the Messianic Ethos of Mozambique’s Socialism, 1974-1988”, in Françoise Blum, ed.African Socialisms and Socialisms in Africa.Paris: Maison des Sciences de l’Homme (forthcoming)“Galo Amanheceu em Lourenço Marques: O 7 de Setembro e o Verso da Descolonização em Moçambique”,Revista Crítica de Ciências Sociais,106 (2015): 53-84“Comparative Politics of Angola, Mozambique, and Guinea-Bissau” (with M. Anne Pitcher),Oxford Bibliographies Online, 2013“State Discourse on Internal Security and the Politics of Punishment in Post-Independence Mozambique (1975-1983)”,Journal of Southern African Studies,37,3 (2011): 593-609“An Archaeological Analysis of Pottery from Massingir District, Southern Mozambique”, (with Solange Macamo)The South African Archaeological Bulletin, 66, 149 (2011): 113-120." + }, + { + "name": "Daniel Magaziner", + "department": "History", + "profile_url": "https://history.yale.edu/people/daniel-magaziner", + "fields_of_interest": "South Africa, modern Africa, religion, political thought, popular culture and the African Diaspora", + "bio": "Dan Magaziner is a historian of 20thcentury Africa. He is the author of three books:The Law and the Prophets: Black Consciousness in South Africa, 1968 – 1977(2010);The Art of Life in South Africa(2016) andAvailable Light: Omar Badsha and the Struggle to Change South Africa(2024). He received his PhD at the University of Wisconsin – Madison in 2007 and taught at Cornell University before coming to Yale in 2011. A specialist in intellectual and cultural history, he teaches 19thand 20thcentury African and South African history; the history of the African diaspora; global and comparative international history. He served as editor forJournal of African Historyand theOhio Short Histories of Africa, as well as the forthcomingOxford Handbook of South African History.Dan is working on two book projects.One, Out of Many: A History of a South African Ideaconsiders how South African and other thinkers from the Global South theorized non-racial and non-nationalist approaches to national identity.  In conversation with thinkers from sites in Southeast Asia, North America, and the Middle East, it traces genealogies of pluralism rooted in formerly colonized peoples’ experiences of racism and exclusion. Dan’s second book, tentatively entitledWorld Man from Africa: Selby Mvusi and the Futuretraces the intellectual itinerary of a South Africa painter, sculptor, theorist, and designer, and recovers histories of utopia from amidst the ruin of the 20thcentury." + }, + { + "name": "Joseph Manning", + "department": "History", + "profile_url": "https://history.yale.edu/people/joseph-manning", + "fields_of_interest": "Ancient Greek history, especially Hellenistic history; eastern Mediterranean through the Roman period; ancient law, the ancient economy; Ancient Egyptian history; Ancient North African history", + "bio": "Manning has a specialized historical focus on Hellenistic history with particular focus on the legal and economic history of Ptolemaic Egypt. His interests include governance, reforms of the state, legal institutions, formation of markets, and the impact of new economic institutions (coinage, banking) on traditional socio-economic patterns in the ancient world. He has also been deeply concerned with Papyrology, the interpretation of ancient sources, and bringing to bear the historical social sciences, particularly Economic Sociology and economic and legal theory, to ancient history. Manning’s research focus over the last ten years has concentrated on historical climate change and its impact on premodern societies more widely. He is the PI of the US National Science foundation project:“Volcanism, Hydrology and Social Conflict: Lessons from Hellenistic and Roman-Era Egypt and Mesopotamia.”\n\nHe has published four monographs: The Hauswaldt Papyri. A Family Archive from Edfu in the Ptolemaic Period.  Demotische Studien, Vol. 12. Würzburg, 1997,Land and power in Ptolemaic Egypt.The structure of land tenure 332-30 BCE. Cambridge University Press, 2003,The last pharaohs. Egypt under the Ptolemies, 305 – 30 BC.Princeton University Press, 2009,andThe Open Sea: The Economic Life of the Ancient Mediterranean World from the Iron Age to the Rise of Rome(Princeton University Press, 2018). His major new work on historic climate change and its impact since the last Ice Age will appear with Norton.\n\nHe has also edited (with Ian Morris, Stanford University) a volume on economic history:The Ancient Economy: Evidence and Models. Stanford University Press, 2005, andLaw and society in Egypt from Alexander to the Arab Conquest (330 BC-640 AD.Co-edited with J.G. Keenan & Uri Yiftach. Cambridge University Press. He is on the editorial boards of Studia Hellenistica (Leuven) and thePalgrave Studies in Ancient Economies.\n\nManning’s current research is situated at the intersection of Paleoclimatology and the economic history of the premodern world. He is particularly interested in ice core geochemistry, a very exciting and dynamic science. Manning is part of a small team that has been working on understanding the impacts of explosive volcanic eruptions on the Nile watershed.  The team has so far focused on the Ptolemaic period but plan on extending the study through Late Antiquity and examining the inter-regional impacts of climate change across the Mediterranean world, with particular focus on the Nile and Euphrates rivers.\n\nBefore coming to Yale, Manning taught for 12 years at Stanford University and two years at Princeton University. Manning is a Professor in both the Classics and the History Departments at Yale, and a Senior Research Scholar at Yale Law School. He is a collaborative member of Yale’s Program in Economic History. He received his B.A. from Ohio State, and his M.A. and Ph.D. from the University of Chicago.\n\nPhoto credit: Karissa Van Tassel Photography" + }, + { + "name": "Ivan Marcus", + "department": "History", + "profile_url": "https://history.yale.edu/people/ivan-marcus", + "fields_of_interest": "History of the Jews in medieval Europe; History of Jewish culture; Jewish-Christian relations; Jewish mysticism & pietism; The Jews & Islam", + "bio": "Ivan G. Marcus is the Frederick P. Rose Professor of Jewish History, Professor of History and of Religious Studies at Yale University. He received his BA from Yale University, magna cum laude, Phi Beta Kappa, his MA from Columbia University, and his MHL and PhD from The Jewish Theological Seminary of America.\n\nBefore joining the Yale faculty, he was Professor of Jewish History at The Jewish Theological Seminary of America, where he was Dean of the Seminary College of Jewish Studies (1976-1981) and Provost (1991-1994). He has also taught at the Hebrew University of Jerusalem as a Lady Davis Fellow and at Princeton where he served on the Advisory Council of the Department of Religion.\n\nHe has writtenPiety and Society: The Jewish Pietists of Medieval Germany(E. J. Brill, 1981), which was a finalist for a National Jewish Book Award,Rituals of Childhood: Jewish Culture and Acculturation in Medieval Europe(Yale University Press, 1996);The Jewish Life Cycle: Rites of Passage from Biblical to Modern Times(University of Washington Press, 2004) based on the 1998 Samuel and Althea Stroum Lectures. His bookSefer Hasidim and the Ashkenazic Book in Medieval Europe(University of Pennsylvania Press, 2018) is a study in the history of the book in medieval Europe. His most recent book is,How the West became Antisemitic(Princeton, 2024), and his translation and edition, A Sefer Hasidim Anthology: The World of Early Ashkenaz,is in press (Yale University Press).\n\nHe has received numerous fellowships including a translation grant and a research fellowship from the National Endowment for the Humanities and a John Simon Guggenheim Memorial Fellowship." + }, + { + "name": "Joanne Meyerowitz", + "department": "History", + "profile_url": "https://history.yale.edu/people/joanne-meyerowitz", + "fields_of_interest": "20th century; Gender & sexuality; Global poverty", + "bio": "Joanne Meyerowitz received her B.A. from the University of Chicago and her M.A. and Ph.D. from Stanford University.  She is the author ofWomen Adrift: Independent Wage Earners in Chicago, 1880-1930andHow Sex Changed: A History of Transsexuality in the United States,and the editor ofNot June Cleaver: Women and Gender in Postwar America, 1945-1960andHistory and September 11th.Her most recent book,A War on Global Poverty: The Lost Promise of Redistribution and the Rise of Microcredit(2021), is a history of U.S. involvement in campaigns to end global poverty in the 1970s and 1980s.   It shows how and why anti-poverty efforts increasingly focused on women as the deserving poor.Before joining the faculty at Yale in 2004, she taught at the University of Cincinnati and Indiana University, and for five years edited theJournal of American History, the leading scholarly journal in U.S. history.  She has won fellowships from, among others, the American Council of Learned Societies, John Simon Guggenheim Foundation, National Humanities Center, Radcliffe Institute for Advanced Study, and Social Science Research Council.  Her books have won prizes from the American Library Association, Foreword Magazine, and the Society for Historians of American Foreign Relations, and her public writing has appeared in, among others, theChicago Tribune,Los Angeles Times,Politico,Time, andWashington Post. At the University of Cincinnati, she won the Dean’s Award for Distinguished Teaching, and at Yale, she won the Graduate Mentor Award in the Humanities. She is an elected member of the Society of American Historians and past president of the Organization of American Historians.At Yale, she has served as chair of LGBT Studies, chair of American Studies, and acting chair of the Department of History.  She is currently co-director of theYale Research Initiative on the History of Sexualities.  She teaches courses on recent U.S. history, gender, and sexuality.A few articles:“How ‘Women’s Empowerment’ Lost Its Meaning,”Time Magazine, March 6, 2024“September 11thRevisited: The Troubled History of Victim Compensation,”Modern American History(July 2023)“How the War on Global Poverty Failed,”Public Seminar, August 26, 2021“180 Op-Eds: Or How to Make the Present Historical,”Journal of American History107:2 (September 2020)“The Liberal 1950s? Reinterpreting Postwar U.S. Sexual Culture,”in Karen Hagemann and Sonya Michel, eds.,Gender and the Long Postwar: Reconsiderations of the United States and the Two Germanys, 1945-1989(Johns Hopkins University Press and Woodrow Wilson Center Press, 2014), 297-319“‘How Common Culture Shapes the Separate Lives’:  Sexuality, Race, and Mid-Twentieth-Century Social Constructionist Thought,”Journal of American History96:4 (March 2010), 1057-1084“Transnational Sex and U.S. History,”American Historical Review114:5 (December 2009), 1273-1286“A History of ‘Gender,’”American Historical Review113:5 (December, 2008), 1346-1356" + }, + { + "name": "Alan Mikhail", + "department": "History", + "profile_url": "https://history.yale.edu/people/alan-mikhail", + "fields_of_interest": "Middle East, Early Modern Muslim World, Ottoman Empire, Egypt, Environmental History, Early Modern History, History of Medicine", + "bio": "Alan Mikhail is the author of five books and editor of another. His work has helped to establish the field of Middle East environmental history, positioned the Ottoman Empire at the center of global early modern history, and creatively scrutinized the place of the archive in the making of past and present. He is currently working on the intertwined histories of Islam and colonial America.\n\nHis most recent book,My Egypt Archive, received the Victor Turner Prize in Ethnographic Writing of the Society for Humanistic Anthropology\n\nHis previous bookGod’s Shadow: Sultan Selim, His Ottoman Empire, and the Making of the Modern Worldwon the Gold Medal in World History from the Independent Publisher Book Awards, was a finalist for the Connecticut Book Award, was longlisted for the Andrew Carnegie Medal for Excellence, and was named a book of the year by theTimes Literary Supplement,History Today,Publishers Weekly, andGlamour.\n\nBefore that,Under Osman’s Tree: The Ottoman Empire, Egypt, and Environmental Historyreceived the Ottoman and Turkish Studies Association Book Prize and was named aChoiceOutstanding Academic Title.Nature and Empire in Ottoman Egypt: An Environmental Historywon the Roger Owen Book Award of the Middle East Studies Association. Both it andThe Animal in Ottoman Egyptwon Yale’s Gustav Ranis International Book Prize. Mikhail’s articles in theAmerican Historical Review,Environmental History, and theInternational Journal of Middle East Studiesreceived prizes as well.\n\nHe has written for theNew York Times,Washington Post,Wall Street Journal,Los Angeles Times,Literary Hub, andTime." + }, + { + "name": "Samuel Moyn", + "department": "History", + "profile_url": "https://history.yale.edu/people/samuel-moyn", + "fields_of_interest": "Modern intellectual history, international history, and legal history", + "bio": "Samuel Moyn is the Kent Professor of Law and History at Yale University, where he also serves as head ofGrace Hopper College.\n\nHis forthcoming book isGerontocracy in America: How the Old Hoard Power and Wealth — and What to Do About It,scheduled to appear from Farrar, Straus and Giroux in June 2026.\n\nTrained in modern European intellectual history, he works on political and legal thought in modern times and on constitutional and international law in historical and current perspective. His most recent book isLiberalism against Itself: Cold War Intellectuals and the Making of Our Times(Yale University Press, 2023), based on theCarlyle Lecturesin the History of Political Thought at the University of Oxford.\n\nHe spent a decade writing some books about the history of international law and human rights,The Last Utopia: Human Rights in History(Harvard University Press, 2010);Christian Human Rights(Penn Press, 2015), based on Mellon Distinguished Lectures at the University of Pennsylvania in fall 2014;Not Enough: Human Rights in an Unequal World(Harvard, 2018); andHumane: How the United States Abandoned Peace and Reinvented War, (Farrar, Straus & Giroux, 2021), which came out in a paperback edition in 2022 withPicadorin the United States andVersoin the United Kingdom.\n\nCurrently he is working on (different) projects constitutionalism and democracy, legal theory, and the Vietnam war.\n\nMoyn is a fellow of theQuincy Institute for Responsible Statecraft, Over the years he has written in venues such as theAtlantic,Boston Review, theChronicle of HigherEducation,Commonweal,Dissent,theGuardian, theLondon Review of Books, The Nation,The NewRepublic,theNew York Times, theWall Street Journal, and theWashington Post." + }, + { + "name": "Isaac Nakhimovsky", + "department": "History", + "profile_url": "https://history.yale.edu/people/isaac-nakhimovsky", + "fields_of_interest": "Intellectual history of Europe since the 17th century; history of political thought; historiography of international law and political economy", + "bio": "Isaac Nakhimovsky is Associate Professor of History and Humanities. He is the author ofThe Holy Alliance: Liberalism and the Politics of Federation(Princeton, 2024) as well asThe Closed Commercial State: Perpetual Peace and Commercial Society from Rousseau to Fichte(Princeton, 2011). He has also collaborated on an edition of Fichte’sAddresses to the German Nation(Hackett, 2013) and two volumes of essays on eighteenth-century political thought and its post-revolutionary legacies:Commerce and Peace in the Enlightenment(Cambridge, 2017), andMarkets, Morals, Politics: Jealousy of Trade and the History of Political Thought(Harvard, 2018). In June 2022 he delivered theQuentin Skinner Lectureat the University of Cambridge.\n\n“Georg Lukács and Revolutionary Realpolitik, 1918–19: An Essay on Ethical Action, Historical Judgment, and the History of Political Thought,”Journal of the History of Ideas83, no. 1 (2022): 63-85." + }, + { + "name": "Vanessa Ogle", + "department": "History", + "profile_url": "https://history.yale.edu/people/vanessa-ogle", + "fields_of_interest": "Economic history; history of capitalism; political economy; modern European history; global and intl. history; comparative empires and decolonization", + "bio": "I am a historian of global Europe from the 18th century to the present, focusing on the history of capitalism, economic history, and empire in global and comparative perspective. While my particular interests lie in Western Europe (Britain, Germany, Switzerland, France mostly), I conceive of Europe broadly and seek to place European history in the context of its interactions with the wider world. Before coming to Yale University, I was a faculty member at the University of Pennsylvania and UC Berkeley.I am currently completing a book on the history of offshore capitalism from the late 19thcentury to the present.Offshore: A Global History of Havens(to be published withVikingin the US andAllen Lanein the UK), reopens the history of twentieth-century political economy and capitalism by excavating an economic, legal, and political regime of smaller, often enclave-like territories and spaces that thrived on the sidelines of a world otherwise increasingly dominated by nation-states. For the first time,Offshorecomprehensively tells the story of how these evasion havens were made and why, who benefitted from these enclaves, and what this tells us about global capitalism in the 20thand 21stcentury. The project is based on several years of painstaking archival research combining documents from over 30 national archives, central banks, multilateral institutions, private banks, and oral history interviews in locations such as Australia, Bahamas, Britain, Canada, Cayman Islands, France, Germany, Ireland, Jersey, Luxembourg, Switzerland, and the US.My first book,The Global Transformation of Time: 1870-1950 (Harvard University Press), explored the history of globalization, tracing changing political, economic, and legal regimes of time during an area of intensified interactions between Europe and other world regions. The book follows time in its different manifestations as social and economic clock time and calendar time from Germany, France, and Britain to British India, the colonial world broadly, the late Ottoman Levant and Egypt, and the League of Nations. TheGlobal Transformation of Timereceived three awards, including the George Louis Beer Prize from the American Historical Association.My work has been supported by fellowships from the ACLS, the Institute for Advanced Study – Princeton, the Institute for New Economic Thinking (INET), the Leverhulme Foundation (UK), a New Directions Fellowship from the Mellon Foundation, the NEH, the Shelby Cullom Davis Center (Princeton University), among others. I have held visiting professorships at King’s College London and the University of Sydney. In 2022, I was the recipient of a Max Planck – Humboldt Medal in the humanities and social sciences, given every three years to up to two researchers outside Germany whose past innovative research promises future breakthroughs.Book:The Global Transformation of Time: 1870–1950(Harvard University Press, 2015)AHA George Louis Beer PrizeBerkshire Conference Prize for best first book by a womanSocial Science History Association Award best first book manuscriptSelected Essays, Articles:“The Dirty Gold Rush,”New York Review of Books, Feb. 1, 2025 (ca. 3,600 words)“Noblesse Without Oblige,”Dissent,Winter 2025 (ca. 2,600 words)“In the Zone of the Rich,”The Nation, Nov. 26, 2024 (ca. 3,200 words)“Shipping’s Shadow World,”New York Review of Books, April 9, 2024 (ca. 3,604 words)“Governing Global Tax Dodgers: The ‘Group of Four’s Attempts to Curb Multinational Tax Avoidance 1970-1980s,”Business History Review97, no. 3 (2023): 547-574“Narratives of Development and Growth,”Journal of Modern European History21, vol. 4 (Nov. 2023).Review essayas part of H-Diplo roundtable on Jamie Martin,The Meddlers, ca. 2,700 words, June 2023“Decolonizing Britain: An Exchange,” with Erik Linstrum, Stuard Ward, Vanessa Ogle, Saima Nasar, Priyamveda Gopal,”Twentieth Century British History33 (July 2022), 274-303“Global Capitalist Infrastructure and U.S. Power,”Cambridge History of America and the World, ed. Mark Bradley, vol. 4:The Twentieth Century, eds. David Engerman, Max Paul Friedman, Melani McAlister, 31-54“‘Funk Money’: The End of Empires, the Expansion of Tax havens, and Decolonisation as an Economic and Financial Event,”Past & Present249, no. 1 (2020), 213-249“Time, Temporality and the History of Capitalism,”Past & Present243, no. 1 (2019): 312-327“Archipelago Capitalism: Tax Havens, Offshore Money, and the State, 1950s-1970s,”American Historical Review122, No. 5 (2017): 1431-1458SHAFR Bernath Prize for best article on the history of US foreign relations, 2018Berkshire Conference of Women Historians Prize for best article on any topic, 2018“State Rights against Private Capital: The “New International Economic Order” and the Struggle over Aid, Trade, and Foreign Investment, 1962-1980,”Humanity5 no. 2 (2014): 211-234“Whose Time Is It? The Pluralization of Time and the Global Condition, 1870s-1940s,”American Historical Review120, no. 5 (2013): 1376-1402Best Article Prize, Council for European Studies, 2014" + }, + { + "name": "Mark Peterson", + "department": "History", + "profile_url": "https://history.yale.edu/people/mark-peterson", + "fields_of_interest": "Early North America and the Atlantic world", + "bio": "Professor Mark Peterson, a specialist in early North America and the Atlantic world, joined the Yale History Department in July 2018.  He earned his Ph.D. in History at Harvard University, and taught previously at the University of Iowa from 1998 to 2007, and at the University of California, Berkeley, from 2007 to 2018, where he was Chair of the History Department from 2015-2018.  His most recent book isThe City-State of Boston: The Rise and Fall of an Atlantic Power, 1630-1865(Princeton University Press, 2019, paperback, 2020), and he is also the author ofThe Price of Redemption: The Spiritual Economy of Puritan New England(Stanford University Press, 1997).  At the moment, he is at work on two new books for Princeton University Press. The first,The Long Crisis of the Constitution, offers a historical account of the US Constitution as a political compromise based on 18th-century conceptions of power and property, and describes how the slow erosion of its original premises in the face of a changing US population and economy have left the nation politically unmoored.  The second,Revolution’s Ends: A History of the American Revolution for the 21stCentury, is a new narrative history of the major conflicts of late-18th-century North America, designed to offer useful frameworks for understanding the processes that generated an independent and consolidated United States, in order to better grasp the prospects for the nation and its place in the world today.  Besides these current projects, Professor Peterson is also planning a third volume of his New England trilogy, focused on the transformation of material culture, consumer demand, and public expenditure from the 16thto the 19thcentury.  He is also completing an edited volume of the writings of John Hull, a 17th-century Boston merchant, mint-master, and political leader, for publication by the Colonial Society of Massachusetts.  In addition, Professor Peterson also serves as co-editor for the book series,American Beginningspublished by the University of Chicago Press." + }, + { + "name": "Stephen Pitti", + "department": "History", + "profile_url": "https://history.yale.edu/people/stephen-pitti", + "fields_of_interest": "History of Mexican Americans; US West; Latinos; 19th & 20th century immigration; US-Mexico border; Labor history", + "bio": "Professor Pitti, who was raised in Sacramento, California, and received his PhD from Stanford University in 1998, is the author ofThe Devil in Silicon Valley: Race, Mexican Americans, and Northern California(2003) and articles on Chicano history and historiography. He is currently working on two book projects:The World of Céasar Chávez(forthcoming, Yale University Press) andLeaving California: Race from the Golden State(in process).\n\nHe teaches graduate and undergraduate courses in Latino Studies, Ethnic Studies, Western History, 20th-century immigration, civil rights, and related subjects. He currently serves as the Director of Undergraduate Studies of Yale’s American Studies Program. And he directs theLatina/o History Project, which explores ethnic Mexican, Puerto Rican, Dominican, Cuban, and other Latino histories in the United States, their links and divisions, their diversity, and their cultures and politics." + }, + { + "name": "Nana Osei Quarshie", + "department": "History", + "profile_url": "https://history.yale.edu/people/nana-osei-quarshie", + "fields_of_interest": "West Africa; Medicine; Migration and Political Expulsions; Urbanization", + "bio": "Nana Osei Quarshie is Assistant Professor in the Program in the History of Science and Medicine at Yale University, where he is also affiliated with the Department of Anthropology and the Yale School of Medicine. An anthropologist and historian by training, Quarshie examines the relationship among mental healing, political expulsions, immigration, and urban belonging in West Africa since the seventeenth century. His research has been funded by the Chateaubriand Fellowship, the Social Science Research Council’s International Dissertation Research Fellowship, the University of Michigan, and Yale University. Among other venues, Quarshie’s writing has appeared or is forthcoming inComparative Studies in Society and History, Bulletin of the History of Medicine,Politique Africaine,Psychopathologie AfricaineandSomatosphere. He is currently revising his first monograph,An African Pharmakon: Psychiatry and the Mind Politic of Modern Ghana.EducationPh.D., Anthropology & History, University of Michigan, Ann Arbor, 2020M.A., History & Literature, Columbia University/ENS – Ulm/EHESS, 2013M.Sc., Race, Ethnicity, & Postcolonial Studies, London School of Economics, 2012H.B.A., African Studies, History, & Political Science, University of Toronto, St. George, 2011PublicationsJournal Articles2024, “Cocoa and Compliance: How Exemptions Made Mass Expulsion in Ghana,”History and Anthropology.https://doi.org/10.1080/02757206.2023.22757882023, “Spiritual Pawning: “Mad Slaves” and Mental Healing in Atlantic-era West Africa,”Comparative Studies in Society and History65: 3, 475 – 499.https://doi.org/10.1017/S00104175230000512024 Jack Goody Award2024 James L. Clifford Prize (Honorable Mention)Cited in the New York Times2022, “Psychiatry on a Shoestring: West Africa and the Global Movements of Deinstitutionalization,”Bulletin of the History of Medicine96, no. 2: 237 – 265.https://doi.org/10.1353/bhm.2022.00232023 Walter D. Love Prize in British History from the North American Conference on British Studies (NACBS)2023 Forum for History of Human Science (FHHS) Article Prize2020, “Contracted Intimacies: Psychiatric Nursing Conspiracies in the Gold Coast,”Politique Africainen° 157: 91 – 110.https://doi.org/10.3917/polaf.157.00912015, “Confinement in the Lunatic Asylums of the Gold Coast from 1887-1906,”Psychopathologie Africaine(36) 2: 191 – 226.Book ChaptersForthcoming: “Archives of False Prophets: Inventing the Future in a West African Psychiatric Hospital” inPsychiatric Contours and New African Histories of Madness.Eds. Hubertus Büschel and Nancy Rose Hunt. Durham, NC: Duke University Press.https://www.dukeupress.edu/psychiatric-contours2021: “Mass Expulsion as Internal Exclusion: Police Raids and the Imprisonment of West African Immigrants in Ghana, 1969 – 1974” inConfinement, Punishment, and Prisons in Africa. Eds. Julia Hornberger, Frederic le Marcis and Marie Morelle. London, UK and New York, NY: Routledge Press, p. 40 – 54.https://doi.org/10.4324/9781003009627-5Translated and Republished as « L’expulsion en masse comme outil d’exclusion intérieure: raids de police et emprisonnement des migrants d’Afrique occidentale au Ghana, 1969–1974 » dansL’Afrique en Prisons. Édité par Frederic le Marcis et Marie Morelle. Lyon, France: ENS Editions, 2022, p. 259 – 275.https://doi.org/10.4000/books.enseditions.40895Book Reviews2020 “Katie Kilroy-Marac’sAn Impossible Inheritance: Postcolonial Psychiatry and the Work of Memory in a West African Clinic” (Review) inSomatosphere: Science, Medicine, and Anthropology.http://somatosphere.net/2020/kilroy-marac-impossible-inheritance.html/Interviews2021: “From Unconventional Archives to Troves of Hauntings” with Sarah Pickman, for The Order of Multitudes, Sawyer Seminar.https://web.archive.org/web/20221202120440/https://orderofm.com/conversation/from-unconventional-archives-to-troves-of-hauntings/" + }, + { + "name": "Bill Rankin", + "department": "History", + "profile_url": "https://history.yale.edu/people/bill-rankin", + "fields_of_interest": "Modern geographic and environmental sciences; history of technology; mapping, spatial history, and digital humanities; visual scholarship", + "bio": "Bill Rankin’s research focuses on the intersection of science, technology, and geography, from the territorial scale of states and globalization down to the scale of individual buildings. He is particularly interested in the political effects of geographic knowledge—in mapping, the environmental sciences and technology, and methodological problems of digital scholarship, spatial history, and geographic analysis (including GIS).\n\nHis first book,After the Map: Cartography, Navigation, and the Transformation of Territory in the Twentieth Century(University of Chicago Press, 2016), was a history of the mapping sciences in the twentieth century. It tracked the shift from the god’s-eye view of the paper map to the embedded experience of GPS, and it analyzed the role of mapping both in the macropolitics of US global power and in the micropolitics of everyday subjectivity and the unexpected uses of new technologies. It won book prizes in the history of technology, social-science history, and international studies; more information is available on the book’s website,www.afterthemap.info.\n\nHis forthcoming book,Radical Cartography: How Changing Our Maps Can Change Our World(Viking, November 2025), is a historical, methodological, and practical exploration of data mapping. It argues for a new ethic of data visualization centered on the idea ofvisual argument. Instead of the “extractive visualization” of most contemporary mapping, which puts visualization in a subordinate position to “raw” data, it calls for a more interventionist and constructivist approach to spatial imagination grounded in the epistemic values of subjectivity, multiplicity, and uncertainty. The book brings the last two hundred years of mapping and visualization into conversation with Rankin’s own mapping projects, which have been published and exhibited widely in the US, Europe, and Asia. Specific topics range from urban segregation and desert land use to the history of slavery and the geography of climate change; most of these maps are also available on his website,www.radicalcartography.net, maintained since 2003.\n\nGlobal Catastrophe since 1750Cartography, Territory, and IdentityCritical Data Visualization: History, Theory, and PracticeGeography and HistoryWorkshop for Article PublicationProblems in the History of Science\n\nAfter the Map: Cartography, Navigation, and the Transformation of Territory in the Twentieth Century.Chicago: University of Chicago Press, 2016.\n\nWinner of the 2017Sidney Edelstein Prizefor best book from the Society for the History of Technology, the 2017SSHA President’s Book Awardfor best first book from the Social Science History Association, andtwo Yale awards: the 2017Gaddis Smith International Book Prizefrom the Yale MacMillan Center and the 2018Samuel and Ronnie Heyman Prizein the humanities.\n\nLong-form reviews inThe American Historical Review,Diplomatic History,Reviews in History, andThe New Atlantis. Interviews with theToynbee Prize Foundation,New Books Network,Time to Eat the Dogs, andYaleNews. Also reviewed inImago Mundi, Isis, Technology and Culture, Historical Studies in the Natural Sciences, Historical Geography, American Association of Geographers Review of Books, Cartographic Perspectives, Southeastern Geographer, The Geographical Magazine(UK),The Globe Journal(Australia),Tekniikan Waheita(in Swedish),Historische Zeitschrift(in German), andH-Soz-Kult(in German).\n\n“The Accuracy Trap: The Values and Meaning of Algorithmic Mapping, from Mineral Extraction to Climate Change.”Environment and History(online before print, 2020). Winner of the 2021Joel A. Tarr Envirotech Prizefor best article on the history of technology and the environment in the last 18 months (awarded by SHOT, presented at ASEH).\n\n“Mapping Time in the Twentieth (and Twenty-First) Century.” InTime in Maps: From the Age of Discovery to Our Digital Era,edited by Kären Wigen and Caroline Winterer. Chicago: University of Chicago Press, 2020.\n\n“Walls, Borders, and Boundaries in World History.” Long-form conversation with five other scholars.American Historical Review122 (Dec 2017): 1501–1553.\n\n“Zombie Projects, Negative Networks, and Multigenerational Science: The Temporality of the International Map of the World.”Social Studies of Science(June 2017; online 2016): 353–375.\n\n“Global Positioning System.” InCartography in the Twentieth Century, edited by Mark Monmonier. Chicago: University of Chicago Press, 2015.\n\n“The Geography of Radionavigation and the Politics of Intangible Artifacts.”Technology and Culture55 (July 2014): 622–674. Winner of the 2016Maurice Daumas Prizefor the best article in “the history of technology in any period of the past or in any part of the world” and the 2015Bernard S. FinnIEEE History Prizefor the best paper on the history of electrotechnology (power, electronics, telecommunications, and computer science).\n\n“The ‘Person Skilled in the Art’ is Really Quite Conventional: U.S. Patent Drawings and the Persona of the Inventor, 1870–2005.” inMaking and Unmaking Intellectual Property: Creative Production in Legal and Cultural Perspective, edited by Mario Biagioli, Peter Jaszi, and Martha Woodmansee, 55–75. Chicago: University of Chicago Press, 2011.\n\n“Visualizing Disciplines, Transforming Boundaries.” Review ofAtlas of Scienceby Katy Börner.American Scientist99 (May 2011): 254–256.\n\n“The Epistemology of the Suburbs: Knowledge, Production, and Corporate Laboratory Design.”Critical Inquiry(Summer 2010): 771–806.\n\n“Infrastructure and the International Governance of Economic Development, 1950–1965.” InInternationalization of Infrastructures, edited by Jean-François Auger, Jan Jaap Bouma, and Rolf Künneke, 61–75. Delft University of Technology, 2009.\n\n“The Reification of Sound: Recording Technology and the Changing Ontology of Music.”Open Space8/9 (Fall 2006–Spring 2007).\n\n“Seismic Isolation Enhancements for Initial and Advanced LIGO” (coauthor).Classical and Quantum Gravity21 (Special Issue, 7 March 2004): s915–s921. (Erdős number: 6)\n\n“The Slave Insurance Market.”Foreign Policy222 (Jan/Feb 2017): 22–23.\n\nMap: “The Human Hemisphere.” InThe Best American Infographics 2016,edited by Gareth Cook with an introduction by Robert Krulwich. Boston: Houghton Mifflin Harcourt, 2016.\n\n“Redrawing the Map.”ArchitectureBoston18, no. 3 (Summer 2015): 42–45.\n\nMaps: “Actual European Discoveries,” “The Midwest,” and “French Kisses.” InThe Best American Infographics 2014,edited by Gareth Cook with an introduction by Nate Silver. Boston: Houghton Mifflin Harcourt, 2014.\n\nMaps of global agricultural land since 1700. InFood: An Atlas,edited by Darin Jensen. Oakland: Guerrilla Cartography, 2013.\n\n“Cartography and the Reality of Boundaries.”Perspecta42 (Spring 2010): 42–45.\n\n“Urban Legends.”Boston Review35 (Nov/Dec 2010): 5–6.\n\nMaps of US agriculture, demographics, suicide, and subways. InMapping America: Exploring the Continent,edited by Fritz Kessler and Frank Jacobs. London: Black Dog, 2010.\n\n“Landscapes of Specialization.” InEcological Urbanism,edited by Mohsen Mostafavi and Gareth Doherty, 502–503. Baden: Lars Müller, 2010.\n\nMaps for “Arctic Land Grab,”National GeographicVol. 215, No. 5 (May 2009): 108–124.\n\nMaps: “My Cities,” “We The People?” and “The Cargo Chain,” inExperimental Geography: Radical Approaches to Landscape, Cartography, and Urbanism, edited by Nato Thompson, 124–129. Brooklyn: Melville House, 2008.\n\nFor more, seewww.radicalcartography.net." + }, + { + "name": "Manoel Rendeiro Neto", + "department": "History", + "profile_url": "https://history.yale.edu/people/manoel-rendeiro-neto", + "fields_of_interest": "Latin America and the Caribbean, Pan-Amazonian History, Brazilian History, African Diaspora Studies, Indigenous History, Environmental Humanities, and Transimperial Histories", + "bio": "Manoel Rendeiro Neto (he/his/him) holds a B.A. and a teaching degree in History from the University of Brasília, and a M.A. and Ph.D. in Latin American History from the University of California, Davis, with a specialization in African Diaspora Studies. Currently, Rendeiro Neto is a Postdoctoral Associate and Lecturer in the Department of History and Affiliate Fellow at the Program in Agrarian Studies at Yale University. Beginning in the fall of 2026, Rendeiro Neto will assume the position of Assistant Professor of Colonial Latin American History at Yale University.Rendeiro Neto’s research focuses on the role of environmental knowledge in empire-building, ethno-racial stratification, and autonomous territorialization in the emergence of an Afro-Indigenous Amazon. Besides working on his book manuscript “Imperial Tides, Runaway Rivers: Cultivating Knowledge, Labor, and Sovereignty in the Atlantic Amazon (1750-1850),” he is developing articles related to waterscape engineering interventions and slavery in 18th century French Guiana; and Indigenous Amazonian women’s role as commercial agents on inter-village trade of domestic produce during Portuguese colonization. His research has been supported by the Conference on Latin American History, the Dumbarton Oaks in conjunction with the Mellon Foundation, the Huntington Library, the John Carter Brown Library, the Luso-American Development Foundation, University of California Humanities Research Institute, among others.Born and raised in the Brazilian Amazon, Rendeiro Neto is committed to research projects on traditional Afro-Indigenous Amazonian communities and their histories to foster the development of growing interdisciplinary studies about the largest rainforest in the world from early modern times to present day challenges.Selected Publications:Manoel Rendeiro Neto, Lana Sato, Carlos Antônio Carvalho, and Tiago Luís Gil, “Eliminating White Spots: A Disassembly of Curt Nimuendajú’s Indigenist Cartography.”História Da Historiografia: International Journal of Theory and History of Historiography14, no. 37 (2021): 17-61, DOI:https://doi.org/10.15848/hh.v14i37.1686Manoel Rendeiro Neto, João Pedro Galvão Ramalho, Vinicius Sodré Maluly, and Tiago Luís Gil, “Les Groupes Autochtones et La Morphologie de La Conquête en Amérique Portugaise.”Nuevo Mundo Mundos Nuevos, Debates (2020), DOI:https://doi.org/10.4000/nuevomundo.81011Manoel Rendeiro Neto, Tiago Luís Gil, Leonardo Barleta, and et all,Atlas Histórico da América Lusa(Ladeira Livros, 2016)." + }, + { + "name": "Carolyn Roberts", + "department": "History", + "profile_url": "https://history.yale.edu/people/carolyn-roberts", + "fields_of_interest": "Medicine and slavery in the Atlantic world; race, medicine, and science; history of medicine in Africa and the African diaspora; health and protest in African American history; non-Western medicine and global health", + "bio": "Dr. Carolyn Roberts is an historian of science and medicine at Yale University.  She holds a joint appointment in the departments of History/History of Science and Medicine, and African American Studies.  She also holds a secondary appointment at Yale School of Medicine in the Program in the History of Medicine.  Her research investigates how medicine, science, and healthcare, both historically and in the present, can best support human thriving.\n\nAs an historian, Dr. Roberts is particularly interested in mobilizing historical knowledge within strategic, targeted, multidisciplinary solutions in health care today.  With scientific rigor and compassion, Dr. Roberts has been actively creating usable history for medical and nursing students as well as other healthcare professionals.  She has also been involved with initiatives that promote scientific excellence among new generations of STEM students and faculty.\n\nTo further this work, Dr. Roberts is currently building the Tubman Lab for Health Innovation.  As an applied medical history and mixed methods research hub, the Tubman Lab seeks to design and implement pedagogical and curricular innovation in the health care education sector, cutting-edge research into harm reduction, and the development of community-driven health initiatives that create a trickle-up effect to improve quality of care at the institutions meant to serve them.\n\nDr. Roberts is currently working on several book manuscripts, includingTo Heal and to Harm: An Origin Story of Predatory Medicine in the Western World, which is under contract with Harvard University Press.  The book tells the story of the health care system created to support the early modern human trafficking industry (i.e., the slave trade) and its current legacies.  Trafficking millions of African children, women, and men across the Atlantic posed a massive health care challenge that had never existed before in the history of the world.  Predatory medicine was an innovation born out of this unique moment when biology and economics, medical exploitation and profit existed in a bold new relationship.  With a focus on the British slave trade, Dr. Roberts delves deeply into the lived experiences of British and African doctors, scientists, nurses, patients, and apothecaries, as well as early British pharmaceutical companies, to demonstrate how the transatlantic slave trade helped birth medical modernity and how predatory forms of medicine remain with us today.\n\nDr. Roberts is an award-winning educator with deep passion for her students.  She is the 2023 recipient of Yale’s oldest teaching award, the DeVane Medal for Scholarship and Teaching.  She is the 2021 recipient of Yale’s prestigious Sidonie Miskimin Clauss Prize for Teaching Excellence in the Humanities.  Professor Roberts teaches undergraduate and graduate courses in the history of science, medicine, and healthcare from the sixteenth to the twenty-first centuries. Professor Roberts’ courses draw hundreds of students, including her popular lecture course “Sickness and Health in African American History” which gained notice as the largest course enrollment at the university in Spring of 2022.  (The course is currently on hiatus).  In her classroom – whether with five students or five hundred – Professor Roberts creates learning communities that foreground care and compassion alongside scientific rigor and critical thinking as core competencies necessary to wrestle with the complex issues of our day.\n\nDr. Roberts is also a popular workshop leader and speaker who has worked with a variety of corporations, non-profit organizations, and institutions including PBS/NOVA, the Howard Hughes Medical Institute, Mt. Sinai Morningside, and many colleges and universities.  Her media appearances include the PBS/NOVA documentaryThe Violence Paradoxand CNN.\n\nDr. Roberts received an M.A. and PhD from Harvard University, an M.A. from Andover Newton Theological School, and a B.A. from Dartmouth College.\n\nTo schedule an appointment, please click here:calendly.com/carolyn-roberts" + }, + { + "name": "Laura Robson", + "department": "History", + "profile_url": "https://history.yale.edu/people/laura-robson", + "fields_of_interest": "modern Middle East, histories of internationalism, refugee studies, empire and decolonization", + "bio": "Laura Robson is a scholar of international and Middle Eastern history, with a special interest in questions of refugeedom, forced migration, and statelessness. She has published extensively on the topics of refugee and minority rights, forced migration, ethnic cleansing, and the emergence of international legal regimes around resettlement and asylum.\n\nHer most recent books are The League of Nations (with Joseph Maiolo; Cambridge, 2025), a reconsideration of the meaning and import of this first experiment in formal internationalism, andHuman Capital: A History of Putting Refugees to Work(Verso, 2023), a wide-ranging investigation of the many twentieth century schemes to deploy refugees as labor migrants across the globe. She is also the author ofThe Politics of Mass Violence in the Middle East(Oxford, 2020);States of Separation: Transfer, Partition, and the Making of the Modern Middle East(University of California, 2017); andColonialism and Christianity in Mandate Palestine(University of Texas, 2011), as well as editor ofPartitions: A Transnational History of 20th Century Territorial Separatism(with Arie Dubnov; Stanford, 2019) andMinorities and the Modern Arab World: New Perspectives(Syracuse, 2016). With Jennifer Dueck, she is the co-founder and co-editor of StatelessHistories.org, a digital humanities project exploring the varied and multifaceted experience of statelessness in the modern era.\n\nRobson’s current research includes one project documenting the active production and deliberate maintenance of different forms of statelessness across the globe during the long twentieth century, and another on Palestine’s emergence as a laboratory for the development of new and highly interventionist forms of colonial and postcolonial internationalism." + }, + { + "name": "Edward Rugemer", + "department": "History", + "profile_url": "https://history.yale.edu/people/edward-rugemer", + "fields_of_interest": "Comparative slavery & abolition; Antebellum US history", + "bio": "A historian of slavery and abolition, Ed Rugemer grew up in Baltimore, Maryland, and graduated from Fairfield University in 1993. He received his doctorate in History from Boston College in 2005 and joined the faculty at Yale in 2007. His first bookThe Problem of Emancipation: The Caribbean Roots of the American Civil War(Louisiana State University Press, 2008) explores how the abolition of slavery in the British Caribbean shaped the coming of the American Civil War. The book won the Avery Craven Award from the Organization of American Historians for the most original book on the Civil War era; the Samuel and Ronnie Heyman Prize from Yale University; and was co-winner of the Francis B. Simkins Award of the Southern Historical Association for the best first book in southern history.His second book,Slave Law and the Politics of Resistance in the Early Atlantic World(Harvard University Press, 2018),explains how organized slave resistance shaped the formation of Atlantic slavery through a comparative history of Jamaica and South Carolina from their colonial origins until the 1830s. The book won the Jerry H. Bentley Book prize of the World History Association, and the Gustav Ranis International Book Prize of the Yale MacMillan Center.Rugemer’s current projects include editing theCambridge History of the Caribbean, and a book length project on Charles Douglas, a Scottish migrant to Jamaica in the 1750s who became a resident slaveholder and superintendant of the Moore Town Maroons. Rugemer has also published articles in theWilliam and Mary Quarterly, Journal of Southern History,Slavery and Abolition,Reviews in American History, and theJournal of the Civil War Era.At Yale, Professor Rugemer teaches courses at the undergraduate and graduate levels on slavery and abolition in the Atlantic World from about 1500 to 1888. Previous to his career as a historian he served as a Jesuit volunteer, teaching at St. George’s College, a Jesuit high-school for boys in downtown Kingston, Jamaica, from 1994-1996. He continues to work with youth as a Little League baseball coach in New Haven." + }, + { + "name": "Paul Sabin", + "department": "History", + "profile_url": "https://history.yale.edu/people/paul-sabin", + "fields_of_interest": "20th century U.S. history, U.S. and global environmental history, government and political development, American West, energy and resources", + "bio": null + }, + { + "name": "Hannah Shepherd", + "department": "History", + "profile_url": "https://history.yale.edu/people/hannah-shepherd", + "fields_of_interest": "Modern Japanese History, Urban History, Modern Korean History", + "bio": "Hannah Shepherd is Assistant Professor in the Department of History. Before joining the Yale faculty, she was Junior Research Fellow in History at Trinity College, University of Cambridge. She holds degrees from Harvard University (AM, PhD), SOAS (MA), and the University of Oxford (BA Hons).\n\nShepherd’s teaching and research interests focus on modern Japan and its colonial empire, with an emphasis on the connected twentieth-century histories of imperial expansion, urban growth, and movement of peoples between Japan and Korea. Her forthcoming book,The Narrowing Sea: Fukuoka, Pusan, and the Rise and Fall of an Imperial Region(December 2025, University of California Press) focuses on two cities on either side of an imperial border. This project is based on her Ph.D. dissertation, for which she was awarded the 2019 Harold K. Gross Dissertation Prize by the Harvard Department of History. Her broader interests include urban and spatial history, Pacific history, migrants and migrations, and the histories of women in Empire.\n\nShepherd has been a Research Fellow at Waseda University (Tokyo), Yonsei University (Seoul), and Kyushu University (Fukuoka). Her research has been supported by the Japan Foundation, Korea Foundation, and Reischauer Institute of Japanese Studies.  At Yale, Shepherd teaches undergraduate and graduate courses on modern Japanese history, Korea and the Japanese Empire, and the history of colonial and imperial cities.\n\nSelected Publications" + }, + { + "name": "David Sorkin", + "department": "History", + "profile_url": "https://history.yale.edu/people/david-sorkin", + "fields_of_interest": "Modern Jewish history and especially political history", + "bio": "David Sorkin is interestedin offering alternative perspectives to the predominant post-liberal or nationalist interpretation of modern Jewish history.\n\nHe first examined the formation of Jewish culture in the German states, which he came to understand as a “subculture.”The Transformation of German Jewry, 1780-1840(1987) won the Present Tense/Joel H. Cavior Literary Award for History. In a commissioned study of Moses Mendelssohn’s Jewish thought he emphasized the neglected Hebrew works.Moses Mendelssohn and the Religious Enlightenment(1996) has been translated into French, German and Italian. In the Sherman Lectures delivered at Manchester University (UK) he used comparison to remove the “Haskalah” (Jewish Enlightenment) from its conventional parochial setting. Those lectures were published asThe Berlin Haskalah and German Religious Thought(2000).  He crossed confessional boundaries and national borders to reconceive the relationship of the Enlightenment to religion inThe Religious Enlightenment:  Protestants, Jews and Catholics from London to Vienna(2008), which was featured in a New York Times’ “Beliefs” column (October 11, 2008, A21).InJewish Emancipation:  A History Across Five Centuries(2019), he argued that the attainment of civil and political rights or equality is the principal event of modern Jewish history.His new book,The Invention of Modern Jewish Politics:  The Campaign for Citizenship, 1800-1914(2026), restores emancipation politics to a central place in the development of Jewish political history.\n\nHe is the co-editor of four volumes.Profiles in Diversity:  Jews in a Changing Europe, 1750-1870(1998) studies how individual Jews and families experienced major historical changes.New Perspectives on the Haskalah(2001) emerged from the first international conference devoted to the subject.“What History Tells”: George L. Mosse and the Culture of Modern Europe(2004) is a tribute to his undergraduate teacher and mentor.Moses Mendelssohn’s Hebrew Works(2018) (Edward Breuer translator) makes available a broad selection of the Hebrew writings in English for the first time.He also served as Associate Editor ofThe Oxford Handbook of Jewish Studies(2002), which won the National Jewish Book Award.In his capacity as Vice-President of the American Academy for Jewish research, he edited,A Commitment to Scholarship:  The Centenary of the American Academy for Jewish Research(2021).\n\nHe has received grants from the British Academy, the National Endowment for the Humanities and the John Simon Guggenheim Memorial Foundation.  He has twice been a Visiting Professor at the École des Hautes Études en Sciences Sociales (Paris) and at the Scuola Normale Superiore (Pisa).  He has also been a Visiting Fellow at the Max Planck Institut für Geschichte (Göttingen); All Souls College, Oxford; the Center for Advanced Judaic Studies at the University of Pennsylvania; and the Swedish Collegium for Advanced Study, Uppsala.\n\nHe previously taught at Brown (1983-86), Oxford (1986-92), the University of Wisconsin-Madison (1992-2011) and the City University of New York-Graduate Center (2011-14)." + }, + { + "name": "John Harley Warner", + "department": "History", + "profile_url": "https://history.yale.edu/people/john-harley-warner", + "fields_of_interest": "19th & 20th century US medicine and health; Comparative history of medicine (US, Britain, France); Cultural history of science & medicine", + "bio": null + }, + { + "name": "Arne Westad", + "department": "History", + "profile_url": "https://history.yale.edu/people/arne-westad", + "fields_of_interest": "Modern international and global history, history of eastern Asia since the 18th century", + "bio": "Odd Arne Westad is a scholar of modern international and global history, with a specialization in the history of eastern Asia since the 18th century.  He studied history, philosophy, and modern languages at the University of Oslo before doing a graduate degree in US/international history at the University of North Carolina at Chapel Hill, where he primarily worked with Michael H. Hunt.  Westad has published sixteen books, most of which deal with twentieth century Asian and global history.In the first part of his career, Westad was mainly preoccupied with the history of the Cold War, China-Russia relations, and the history of the Chinese civil war and the Chinese Communist Party.  He published two monographs, Cold War and Revolution, which deals with US and Soviet intervention in the Chinese Civil War in 1944-1946, and Decisive Encounters, which is a general history of the Chinese civil war and the Communist victory in the period from 1946 to 1950.  He also edited several books on Sino-Soviet and Cold War history topics.Since the mid-2000s, Westad has been concerned with more general aspects of post-colonial and global history, as well as the modern history of China.  The three key works from this period are The Global Cold War, which argues for ways of understanding the Soviet-American conflict in light of late- and post-colonial change in Asia, Africa, and the Caribbean; Restless Empire, which discusses broad trends in China’s international history since 1750; and The Cold War: A World History, which summarizes the origins, conduct, and results of the conflict on a global scale.Today Westad is mainly interested in researching histories of empire and imperialism, first and foremost in Asia, but also world-wide.  He is also trying to figure out how China’s late twentieth century economic reforms came into being and how their results changed the global economy.Westad joined the faculty at Yale after teaching at the London School of Economics, where he was School Professor of International History, and at Harvard University, where he was the S.T. Lee Professor of US-Asia Relations.  He is a fellow of the British Academy and of several other national academies." + }, + { + "name": "Jonathan Wyrtzen", + "department": "History", + "profile_url": "https://history.yale.edu/people/jonathan-wyrtzen", + "fields_of_interest": "Modern North Africa, Middle East, empire, colonialism, nationalism, ethnicity, state-formation", + "bio": "Books\n\nArticles\n\nChapters, Reviews, and Other\n\nGraduate\n\nAffiliations\n\nNational & International" + }, + { + "name": "Nurfadzilah Yahaya", + "department": "History", + "profile_url": "https://history.yale.edu/people/nurfadzilah-yahaya", + "fields_of_interest": "History of Southeast Asia; History of Indian Ocean; History of Islamic World; Global and International History; Colonialism and Imperialism; Environmental History; History of Infrastructure; Legal History; Islamic law", + "bio": "Nurfadzilah Yahaya traces how colonial institutional frameworks built enduring juridical, territorial, and extractive architectures that decisively transformed societies and still influence contemporary relations between communities, resource access, and state power.Her first book,Fluid Jurisdictions: Colonial Law and the Arab Diaspora in Southeast Asia(Cornell University Press, 2020), examines how Arab commercial elites maneuvering within British and Dutch legal frameworks helped define imperial sovereignty. Their strategies to safeguard international family estates through colonial judicial systems dissolved boundaries between private agreements and public law, creating jurisdictional spillover where subjects pursuing legal security unintentionally expanded imperial control.Her second book,Overflow: History of Land Reclamation in the British Empire(under review) traces how legal authority materialized in physical space. Land reclamation, which transforms seabed into sovereign territory, exemplifies infrastructure’s most audacious achievement by manufacturing geography itself. From Malaya to Palestine, Hong Kong to the Caribbean, British authorities did not just conquer existing lands but created new ones from dredged sediment and legal precedent. She is currently writing two books; the first on history of petroleum in Indonesia, and the second, a global history of the Dutch empire.She has published inJournal of Women’s History, Law and History Review,Indonesia and Malay WorldandMuslim World. She has also co-edited two journal special issues on Islam and colonialism, and the religious endowment known as ‘waqf.’Yahaya received her BA (2003) and MA (2006) from the National University of Singapore, and her PhD (2012) in History from Princeton University. From 2012 to 2015, she was the Mark Steinberg Weil Early Career Fellow in Islamic Studies at Washington University in St. Louis. Before coming to Yale, she taught at the National University of Singapore. At Yale, she offers courses on histories of Southeast Asia, Islamic world, British Empire, Dutch Empire, and the Indian Ocean.Selected publicationsBookFluid Jurisdictions: Colonial Law and Arabs in Southeast Asia,Ithaca: Cornell University Press 2020Articles“Class, White Women and Elite Asian Men in British Courts during the Late Nineteenth Century”Journal of Women’s History, 31.2 (Summer 2019): 101-123“Legal Pluralism and the East India Company in the Straits of Malacca, 1786-1821,”Law and History Review, 33.4 (November 2015): 945-964“Craving Bureaucracy: Marriage, Islamic Law, and Arab Petitioners in the Straits Settlements,”Muslim World, 105.4 (October 2015): 496-515“The Question of Animal Slaughter in the British Straits Settlements during the Early Twentieth Century”Indonesia and the Malay World43,126 (July 2015): 173-190; Winner of theIndonesia and the Malay WorldYoung Scholar Prize" + }, + { + "name": "Alden Young", + "department": "History", + "profile_url": "https://history.yale.edu/people/alden-young", + "fields_of_interest": "Modern Africa, Modern Middle East, Histories of the Red Sea, History of economic development and the social sciences, and American empire", + "bio": "Alden Young is an associate professor of History and Global Affairs at Yale University. He is a political and economic historian of Africa and the Middle East. His first book,Transforming Sudandiscusses the role of the new science of economic development in the transition of Sudan from an imperial possession to a newly independent state.  Alden is currently at work on two new books. The first is tentatively entitledThe Afrabiansand it uses the writings of the Sudanese scholar Muhammad Abu al-Qasim Hajj Hamad to tell the story of the relationship between northeast Africa and the Arab Gulf states from the 1970s until the early 2000s. Alden is also writing a book on post-partition conflicts in the Horn of Africa (e.g., Sudan-South Sudan and Ethiopia-Eritrea) with the political scientist Michael Woldemariam. Alden recently completed a project on the perceptions and impacts of climate change in the countries that form the Red Sea Basin with Nathalie Puetz of NYU Abu Dhabi and Dheaya Alrousan of the Hashemite University in Zarqa, Jordan. This collaboration with scholars in nine countries resulted in the creation ofRed Sea Net, a digital resource. To learn more about the gestation of this project please read the following article inItems.Alden comes to Yale from UCLA where he was an associate professor of African American Studies at UCLA and a standing member of the faculty in the International Institute. Before that he taught for five years in the History Department at Drexel University. He has been a fellow of the Berggruen Institute and a member of the School of Social Science at the Institute for Advanced Study in Princeton. He has published numerous academic journals and writes frequently in popular forums like Foreign Affairs, Foreign Policy, and Noema Magazine.Recent Publications:Transforming Sudan: Decolonization, Economic Development and State Formation(Cambridge 2018/2020)“How Sudan’s Wars of Succession Shape the Current Conflict,” ReportForeign Policy Research Institute(July 3, 2024).With Keren Weitzberg, “Globalizing Racism and De-provincializing Muslim Africa,”Modern Intellectual History(2022) 19:3 pp: 912-933.“The Intellectual Origins of Sudan’s ‘Decades of Solitude,’ 1989-2019,”Capitalism: A Journal of History and Economics(2021) 2:1: pp: 196-226With Michael Woldemariam,“After the Split: Partition, Successor States, and the Dynamics of War in the Horn of Africa,”Journal of Strategic Studies(2018) 41:5: pp: 684-720" + } +] \ No newline at end of file diff --git a/yale_medicine_labs.json b/yale_medicine_labs.json new file mode 100644 index 0000000..1a1dab6 --- /dev/null +++ b/yale_medicine_labs.json @@ -0,0 +1,14875 @@ +[ + { + "lab_name": "3D Tumor Lab", + "lab_url": "https://medicine.yale.edu/lab/3d-tumor-lab/", + "research_bio": "INFORMATION FOR Copy Link In 2022, we encountered a patient with Neurofibromatosis Type 2 (NF2) who presented with bi-lateral vestibular schwannomas who reported a worsening of symptoms, despite being told that their tumors had not grown over the past 6 years. It became clear that there was an issue with the current methods for measuring tumor growth with the common method being measuring linear distances on a single MRI slice. We questioned if this method was accurately detecting this specific patient's tumor growth over the years. At that time, 3D segmentation technology, which had gained popularity in orthopedics for analyzing bones in multiple planes, caught our attention. We wondered: why couldn't this technology be applied to brain tumors? Inspired by its success in other fields, we began manually segmenting MRIs of this patient's vestibular schwannomas over several years. Our analysis revealed a startling discrepancy: while the patient had been informed that their tumor had remained stable, it had actually grown to four times its original volume. This unchecked growth rendered the tumors inoperable, significantly impacting the patient's treatment options. This experience underscored the need for more accurate tumor analysis and led to the creation of the 3D Tumor Lab. We realized that this problem likely affected many other patients who had only received linear tumor assessments. Thus, our mission is to enhance the accessibility and precision of 3D tumor growth analysis. We aim to advance from manual segmentation to an automated system that generates 3D models of tumors with just the click of a button, ultimately offering patients improved chances for recovery and survival. 00:00:40 Copy Link Our lab is focused on developing software to automate the identification, measurement, and growth of central nervous system (CNS) tumors. Our goal is to generate clinical tools that are easy to use, accessible and fast so that volumetric tumor analysis can be used in clinical settings. Did you know that commonly used 2D tumor analysis methods drastically underestimate the growth rates of tumors, causing clinicians to make uninformed decisions? Our lab has demonstrated inaccuracies in the current standard of care for measuring tumor growth. Did you know that the only widely available method to measure tumor volumes involves time intensive manual segmentation that can take 3-4 hours per scan? Our AI can generate 3D tumor models for volumetric analysis within minutes and is highly accurate. We are a team made up of innovative physicians, students and engineers dedicated to using advanced technologies to deliver faster, more accurate and more accessible information to improve patient outcomes.", + "publications_page": "https://medicine.yale.edu/lab/3d-tumor-lab/publications", + "publications": [ + "Yale School of Medicine /", + "Orthopaedics & Rehabilitation /", + "Research Projects", + "Contact Us", + "People", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research Projects", + "People", + "Publications", + "News", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Desroches, S. T., Huang, A., Ghankot, R., Tommasini, S. M., Wiznia, D. H., & Buono, F. D. (2025). Clinician Perspectives of a Magnetic Resonance Imaging–Based 3D Volumetric Analysis Tool for Neurofibromatosis Type 2–Related Schwannomatosis: Qualitative Pilot Study. JMIR Hum Factors, 12, e71728. https://pubmed.ncbi.nlm.nih.gov/40737523/", + "Ghankot, R. S., Singh, M., Desroches, S. T., Jester, N., Mahajan, A., Lorr, S., . . . Tommasini, S. M. (2025). Evaluating the effect of voxel size on the accuracy of 3D volumetric analysis measurements of brain tumors. Frontiers in Radiology, Volume 5 - 2025. https://pubmed.ncbi.nlm.nih.gov/40842873/", + "Manwi Singh, Noemi Jester, Samantha Lorr, Alexis Briano, Nofrat Schwartz, Amit Mahajan, Veronica Chiang, Steven M. Tommasini, Daniel H. Wiznia, Frank D. Buono, The implementation of artificial intelligence in serial monitoring of post gamma knife vestibular schwannomas: A pilot study, Clinical Imaging, Volume 123, 2025, 110495, ISSN 0899-7071, https://doi.org/10.1016/j.clinimag.2025.110495 .", + "Jester, N., Singh, M., Lorr, S. et al. The development of an artificial intelligence auto-segmentation tool for 3D volumetric analysis of vestibular schwannomas. Sci Rep 15, 5918 (2025). https://doi.org/10.1038/s41598-025-88589-x", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Abujarad's Digital Health Lab", + "lab_url": "https://medicine.yale.edu/lab/abujarad/", + "research_bio": "INFORMATION FOR Welcome to Abujarad's Digital Health Lab! Dr. Abujarad’s primary research area is in digital health. Currently, Dr. Abujarad is utilizing Digital Health to improve patient health outcomes while decreasing costs and unnecessary hospitalizations and emergency department visits. His specific research interests focus on the area of Digital Health, Gerontechnology, Elder Mistreatment, Informed Consent, and systems that provide real-time background searches. His overarching aim is to apply his in-depth knowledge and methodological expertise to address major health disparities in the older adult population by developing technologies that optimize the human interface of complex systems. Currently, his research is focused on developing and testing elder mistreatment screening and identifications tools as well as a web-based patient-centered virtual multimedia interactive informed consent tool to enhance the quality of care and patient safety. This research was recently funded by AHRQ, CMS, and NIH. Specialized Terms: Gerontechnology, Elder Mistreatment, Digital Informed Consent, Digital Health, Digital Background Checks. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/abujarad/publication/", + "publications": [ + "Yale School of Medicine /", + "Emergency Medicine /", + "Research", + "News", + "Projects Virtual cOaching in making Informed Choices on Elder Mistreatment Self-Disclosure Health Information Technology to Prevent Abuse, Neglect, and Exploitation Virtual Multimedia Interactive Informed Consent Radiotherapy For Older Women Workforce Background Check System Area Agency on Aging Service Navigator ED Referral Program", + "Virtual cOaching in making Informed Choices on Elder Mistreatment Self-Disclosure", + "Health Information Technology to Prevent Abuse, Neglect, and Exploitation", + "Virtual Multimedia Interactive Informed Consent", + "Radiotherapy For Older Women", + "Workforce Background Check System", + "Area Agency on Aging Service Navigator ED Referral Program", + "Contact", + "Lab Members", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Projects", + "Lab Members", + "Publications", + "News", + "Contact", + "", + "", + "", + "", + "", + "", + "Stabilizing Interference-Free Slot Assignment for Wireless Mesh Networks Reviewed Book Chapters: M. Arumugam, A. Jhumka, F. Abujarad, and S. S. Kulkarni. Stabilizing Interference-Free Slot Assignment for Wireless Mesh Networks. In Guide to Wireless Mesh Networks, Springer, Editors: Sudip Misra, Subhas Chandra Misra, and Isaac Woungang, ISBN: 978-1-84800-908-0, 2009. (http://www.springer.com/computer/communications/book/978-1-84800-908-0)", + "Complexity Issues in Automated Model Revision Without Explicit Legitimate State Fuad Abujarad, and Sandeep S. Kulkarni. Complexity Issues in Automated Model Revision Without Explicit Legitimate State. International Symposium on Stabilization, Safety, and Security of Distributed Systems (SSS), LNCS 6366, pp. 206-220, September-2010.", + "Effect of Fairness in Model Checking of Self-stabilizing Programs Jingshu Chen, Fuad Abujarad, Sandeep S. Kulkarni. Effect of Fairness in Model Checking of Self-stabilizing Programs. International Conference On Principles Of Distributed Systems (OPODIS) .p.p. 135-138, December-2010.", + "Weakest Invariant Generation for Automated Addition of Fault-Tolerance Fuad Abujarad, and Sandeep S. Kulkarni. Weakest Invariant Generation for Automated Addition of Fault-Tolerance. Electronic Notes in Theoretical Computer Science (ENTCS). 5873, pp.3-15, December-2009", + "Parallelizing Deadlock Resolution in Symbolic Synthesis of Distributed Programs. Fuad Abujarad, Borzoo Bonakdarpour, and Sandeep S. Kulkarni. Parallelizing Deadlock Resolution in Symbolic Synthesis of Distributed Programs. International Workshop on Parallel and Distributed Methods in verifiCation (PDMC), pp. 92-106. November -2009.", + "Constraint Based Automated Synthesis of Nonmasking and Stabilizing Fault-Tolerance Fuad Abujarad, and Sandeep S. Kulkarni. Constraint Based Automated Synthesis of Nonmasking and Stabilizing Fault-Tolerance. 28th International Symposium on Reliable Distributed Systems (SRDS), pp. 119-128, September-2009.", + "Weakest Invariant Generation for Automated Addition of Fault-Tolerance Fuad Abujarad, and Sandeep S. Kulkarni. Weakest Invariant Generation for Automated Addition of Fault-Tolerance. Workshop on Logical Aspects of Fault Tolerance (LAFT), ENTCS 258, pp. 3-15, August-2009.", + "Multicore Constraint-Based Automated Stabilization Fuad Abujarad, and Sandeep S. Kulkarni. Multicore Constraint-Based Automated Stabilization. The 11th International Symposium on Stabilization, Safety, and Security of Distributed Systems (SSS), LNCS 5873, pp.47-61, November-2009.", + "Automated Addition of Fault-Tolerance to SCR Toolset: A case study Fuad Abujarad, and Sandeep S. Kulkarni. Automated Addition of Fault-Tolerance to SCR Toolset: A case study. The Seventh International Workshop on Assurance in Distributed Systems and Networks (ADSN), in ICDCSW '08: Proceedings of the 2008 The 28th International Conference on Distributed Computing Systems Workshops,17-20, pp.539 – 544, June-2008.", + "istributed Synthesis of Fault-Tolerant Programs in the High Atomicity Model Borzoo Bonakdarpour, Sandeep S. Kulkarni, and Fuad Abujarad. Distributed Synthesis of Fault-Tolerant Programs in the High Atomicity Model. International Symposium on Stabilization, Safety, and Security of Distributed Systems (SSS), LNCS 4838, pp.21-36,November 2007.", + "Distributed Synthesis of Fault-Tolerance Borzoo Bonakdarpour, Sandeep S. Kulkarni, and Fuad Abujarad. Distributed Synthesis of Fault-Tolerance. International Symposium on Stabilization, Safety, and Security of Distributed Systems (SSS), LNCS 4280, pp. 566-567, November 2006.", + "Automated Constraint-Based Addition of Nonmasking and Stabilizing Fault-Tolerance Abujarad F and Kulkarni SS. Automated Constraint-Based Addition of Nonmasking and Stabilizing Fault-Tolerance. Journal of Theoretical Computer Science. 2011; 412(33): 4228-4246.", + "Symbolic Synthesis of Masking Fault-tolerant Distributed Programs. Bonakdarpour B, Kulkarni SS, and Abujarad F. Symbolic Synthesis of Masking Fault-tolerant Distributed Programs. Springer Journal of Distributed Computing. 2012; 25(1): 83-108.", + "Towards scalable model checking of self-stabilizing programs. 1. Chen J, Abujarad F, Kulkarni SS. Towards scalable model checking of self-stabilizing programs. Journal of Parallel and Distributed Computing. 2013; 73(4): 400-410.", + "The complexity of automated addition of fault-tolerance without explicit legitimate states. Abujarad F, Lin Y, Bonakdarpour B, Kulkarni SS. The complexity of automated addition of fault-tolerance without explicit legitimate states. Springer journal of Distributed Computing (DC), 2014-8: 1-19", + "Back to the Bedside: Developing a Bedside Aid for Concussion and Brain Injury Decisions in the Emergency Department. 1. Melnick, E, Lopez, K, Hess, E, Abujarad, F, Brandt, C, Shiffman, R, and Post, L, Back to the Bedside: Developing a Bedside Aid for Concussion and Brain Injury Decisions in the Emergency Department. (2015) eGEMs (Generating Evidence & Methods to improve patient outcomes): Vol. 3: Iss. 2, Article 6.", + "Development and validation of the Emergency Department Geriatric Readmission Assessment at Yale (ED GRAY): Part 1 Post, L. A., Conner, T. L., Oehmke, J. F. Abujarad, F., Cooney, L. M., Brandt, C., Page, C., Swierenga, S. J., Biroscak, B. J., Esposito, C., & Dziura, J. (2016). Development and validation of the Emergency Department Geriatric Readmission Assessment at Yale (ED GRAY): Part 1, fundamental measurement. British Journal of Medicine and Medical Research, 14(1), 1-14", + "Development and validation of the Emergency Department Geriatric Readmission Assessment at Yale (ED GRAY): Part 2 1. Post, L. A., Conner, T. L., Oehmke, J. F. Abujarad, F., Cooney, L. M., Brandt, C., Page, C., Swierenga, S. J., Biroscak, B. J., Esposito, C., & Dziura, J. (2016). Development and validation of the Emergency Department Geriatric Readmission Assessment at Yale (ED GRAY): Part 2, prognostic accuracy. British Journal of Medicine and Medical Research, 14(1), 1-8.", + "Real-world user-centered design: The Michigan Workforce Background Check system. Swierenga, S J, Abujarad, F, Dennis, T A, & Post, L A. Real-world user-centered design: The Michigan Workforce Background Check system. In Salvendy, G., and Smith, M. J. (eds.): Human Interface, Part II, HCII 2011, LNCS 6772, 325-334.", + "Improving Patient Safety Through User-Centered Healthcare Background Check System Design. Swierenga, S J, Abujarad, F, Dennis, T A, & Post, L A. Improving Patient Safety Through User-Centered Healthcare Background Check System Design. Poster presentation at the Human Factors and Ergonomic Society Healthcare IT Symposium. Baltimore, MD. 2013", + "ap backs: Continuous workforce monitoring to improve patient safety in long-term care Abujarad, F, Swierenga, S J, Dennis, T A, and Post, L A. Rap backs: Continuous workforce monitoring to improve patient safety in long-term care. In Marcus, A. (ed.), Design, User Experience and Usability, HCII 2013, Part III, LNCS 8014, pp. 3-9. Springer-Verlag Berlin Heidelberg 2013.", + "Real-Time Screening to Improve Patient Safety in Long-term Care. Abujarad, F Swierenga, S J, Dennis, T A, & Post, L A. Real-Time Screening to Improve Patient Safety in Long-term Care. Poster Presentation, The International Symposium on Human Factors and Ergonomics in Health Care: Improving the Outcomes, Chicago, IL. 2014", + "Management of On-Line Registries Information for Patient Safety in Long-Term Care. Abujarad F, Swierenga S, Dennis T, Post L. Management of On-Line Registries Information for Patient Safety in Long-Term Care. Human Interface and the Management of Information. Information and Knowledge in Applications and Services. Vol 8522: Springer International Publishing; 2014:307-316.", + "mHealth as a Means to Address Health Disparities in Alcohol Use Disorders Among Spanish Speaking Latino ED Patients. Abujarad, F, Vaca, F, mHealth as a Means to Address Health Disparities in Alcohol Use Disorders Among Spanish Speaking Latino ED Patients. Poster Presentation, The New England Regional SAEM conference, Boston, MA. 2015", + "mHealth Tool for Alcohol Use Disorders Among Latinos in Emergency Department. 1. Abujarad, F, Nguyen, T, Vaca, F, mHealth Tool for Alcohol Use Disorders Among Latinos in Emergency Department. Poster Presentation, The International Symposium on Human Factors and Ergonomics in Health Care: Improving the Outcomes, Baltimore, MD. 2015", + "The Impact of Usability on Patient Safety in Long-Term Care Abujarad, F, Swierenga, S J, Dennis, T A, & Post, L A. The Impact of Usability on Patient Safety in Long-Term Care. Strategic Social Media and Usability, 2nd International Conference on HCI in Business. Springer International Publishing Switzerland, 2015. 221-231.", + "mHealth Tool for Alcohol Use Disorders Among Latinos in Emergency Department. 1. Abujarad, F, & Vaca, F. E. mHealth Tool for Alcohol Use Disorders Among Latinos in Emergency Department. Proceedings of the International Symposium on Human Factors and Ergonomics in Health Care, 2015; 4(1): 12-19. doi: 10.1177/2327857915041005", + "Seamco Building 464 Congress Avenue New Haven, CT 06510", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "ACCELERATE Advancing Clinical Care and Empowering Research through Technology Lab", + "lab_url": "https://medicine.yale.edu/lab/melnick/", + "research_bio": "INFORMATION FOR Copy Link Dr. Ted Melnick is a transformational leader in clinical informatics and emergency medicine research. As PI of ACCELERATE Advancing Clinical Care and Empowering Research through Technology Lab and Director of the Yale-VA Clinical Informatics Fellowship program, Dr. Melnick and his team's primary goal is to improve the digital health user experience for clinicians and their patients by rigorous application of systems engineering science and principles throughout the lifecycle of digital health innovations. The Lab also has a special emphasis on implementation of scientifically sound EHR use metrics and health services research to improve current delivery systems. ACCELERATE Advancing Clinical Care and Empowering Research through Technology Lab research is funded by the National Institute of Health (currently, NIDA and NIMH), the American Medical Association, and the Agency for Healthcare Research & Quality. Copy Link Weekly lab meetings are held on Tuesday mornings. At these weekly meetings, project updates are discussed in presence of a diverse group to encourage brainstorming and new perspective and inspiration for future projects. Fellows, residents, and students with relevant interest in informatics are encouraged to join these meetings to learn more about the Melnick Lab and discuss their interest. For questions, please reach out toLaurel BuchananorDr. Melnick. Copy Link A decade-long analysis of physicians reveals an acceleration in doctors permanently leaving practice, a trend likely to worsen physician shortages. Copy Link Principal Investigator", + "publications_page": "https://medicine.yale.edu/lab/melnick/publications", + "publications": [ + "Yale School of Medicine /", + "Emergency Medicine /", + "People", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "People", + "Publications", + "News", + "", + "", + "", + "", + "", + "", + "Real-World Evidence Synthesis of Digital Scribes Using Ambient Listening and Generative Artificial Intelligence for Clinician Documentation Workflows: Rapid Review. Kanaparthy NS, Villuendas-Rey Y, Bakare T, Diao Z, Iscoe M, Loza A, Wright D, Safranek C, Faustino IV, Brackett A, Melnick ER, Taylor RA. JMIR AI. 2025 Oct 10; 2025 Oct 10. PMID: 41071988.", + "Trends in and Predictors of Physician Attrition From Clinical Practice Across Specialties : A Nationwide, Longitudinal Analysis. Rotenstein LS, He Z, Dziura J, Tsugawa Y, Venkatesh AK, Melnick ER, Gettel CJ. Ann Intern Med. 2025 Oct 7; 2025 Oct 7. PMID: 41052447.", + "Disentangling informing participants from obtaining their consent. O'Rourke PP, Ali J, Carrithers J, Magnus D, Wilfond BS, Bull S, Dember LM, D'Onofrio G, Goldman J, Ho PM, Melnick ER, Staman KL, Tulsky JA, Vazquez MA, Volandes A, Wendler D. Learn Health Syst. 2025 Oct; 2025 Apr 21. PMID: 41169649.", + "Training Health Communicators - The Need for a New Approach. Panthagani K, Melnick ER, Jetelina K, Ranney ML. N Engl J Med. 2025 Aug 7; 2025 Aug 2. PMID: 40757664.", + "Clinician Perceptions of Virtual Scribe Use: A Survey Study. Prasad K, Frits M, Iannaccone C, Melnick ER, Zhang J, Mugal A, Lipsitz S, Healey M, Holland C, Snyder R, Sinsky C, Ting D, Bates DW, Rotenstein L. J Gen Intern Med. 2025 Aug 5; 2025 Aug 5. PMID: 40762875.", + "A Measurement Science Framework to Optimize CDS for Opioid Use Disorder Treatment in the ED. Iscoe MS, Hooper CD, Levy DR, Lutz J, Paek H, Rose C, Kannampallil T, Meeker D, Dziura JD, Melnick ER. Appl Clin Inform. 2025 Aug; 2025 Aug 20. PMID: 40834872.", + "The Effect of Ambient Artificial Intelligence Scribes on Trainee Documentation Burden. Wright DS, Kanaparthy NS, Melnick ER, Levy DR, Huot SJ, Hsiao A, Schwamm LH, Ong SY. Appl Clin Inform. 2025 Aug; 2025 Jul 2. PMID: 40602775.", + "Boarding in Emergency Department Hallways Circa 2025: Why Older Adult Patients Deserve Better. Pines JM, Ratwani RM, Melnick ER. J Am Geriatr Soc. 2025 Aug; 2025 Jun 24. PMID: 40553078.", + "Health Services Usage in Patients Receiving Buprenorphine for Opioid Use Disorder or Long-Term Opioid Therapy for Chronic Pain: Retrospective Cohort Study. Savitz ST, Stevens MA, Nath B, D'Onofrio G, Melnick ER, Jeffery MM. JMIR Form Res. 2025 Jun 19; 2025 Jun 19. PMID: 40537088.", + "Predicting Agitation Events in the Emergency Department Through Artificial Intelligence. Wong AH, Sapre AV, Wang K, Nath B, Shah D, Kumar A, Faustino IV, Desai R, Hu Y, Robinson L, Meng C, Tong G, Bernstein SL, Yonkers KA, Melnick ER, Dziura JD, Taylor RA. JAMA Netw Open. 2025 May 1; 2025 May 1. PMID: 40332935.", + "Monitoring in pragmatic trials lessons from the NIH pragmatic trials collaboratory. Curtis LH, Morain S, O'Rourke PP, Staman K, Jarvik JG, Cheville A, Dailey DL, Sluka KA, Heagerty P, Melnick ER, Chakraborty H, Tulsky JA, Volandes A, Simon GE. Contemp Clin Trials. 2025 May; 2025 Feb 25. PMID: 40015598.", + "Imputation of missing aggregate EHR audit log data across individual and multiple organizations. Li H, Apathy NC, Holmgren AJ, Melnick ER, McDougal RA. J Biomed Inform. 2025 Mar; 2025 Feb 18. PMID: 39978430.", + "Pre-to-post COVID-19 pandemic trends in time from emergency department arrival to inpatient floor arrival: Door to floor time. Loza AJ, Sangal RB, Gielissen KA, Melnick ER, Sankey C, Ostfeld-Johns S. Am J Emerg Med. 2025 Mar; 2024 Dec 22. PMID: 39731897.", + "Individual and System-level Factors Contributing to Guideline Nonadherent Surgical Antibiotic Prophylaxis at a Tertiary Healthcare System: A Qualitative Analysis. Bardia A, Melnick ER, McCall T, Zhao X, Lin HM, Fisher C, Burg MM, Schonberger RB. Anesthesiology. 2025 Mar 1; 2024 Nov 18. PMID: 39556527.", + "Adaptive decision support for addiction treatment to implement initiation of buprenorphine for opioid use disorder in the emergency department: protocol for the ADAPT Multiphase Optimization Strategy trial. Iscoe MS, Diniz Hooper C, Levy DR, Buchanan L, Dziura J, Meeker D, Taylor RA, D'Onofrio G, Oladele C, Sarpong DF, Paek H, Wilson FP, Heagerty PJ, Delgado MK, Hoppe J, Melnick ER. BMJ Open. 2025 Feb 20; 2025 Feb 20. PMID: 39979056.", + "Impact of electronic health record updates and changes on the delivery and monitoring of interventions in embedded pragmatic clinical trials. Marsolo KA, Cheville A, Melnick ER, Jarvik JG, Simon GE, Sluka KA, Crofford LJ, Staman KL, Richesson RL, Schlaeger JM, Curtis LH. Contemp Clin Trials. 2025 Jan; 2024 Nov 17. PMID: 39561918.", + "Interventions to Mitigate EHR and Documentation Burden in Health Professions Trainees: A Scoping Review. Levy DR, Rossetti SC, Brandt CA, Melnick ER, Hamilton A, Rinne ST, Womack D, Mohan V. Appl Clin Inform. 2025 Jan; 2024 Oct 4. PMID: 39366661.", + "Abbreviated MRI in the evaluation of dizziness: report turnaround times and impact on length of stay compared to CT, CTA, and conventional MRI. Tu LH, Tegtmeyer K, de Oliveira Santo ID, Venkatesh AK, Forman HP, Mahajan A, Melnick ER. Emerg Radiol. 2024 Oct; 2024 Jul 22. PMID: 39034381.", + "Benchmarking Emergency Physician EHR Time per Encounter Based on Patient and Clinical Factors. Iscoe MS, Venkatesh AK, Holland ML, Krumholz HM, Sheares KD, Melnick ER. JAMA Netw Open. 2024 Aug 1; 2024 Aug 1. PMID: 39136949.", + "Trends in the Prescribing of Buprenorphine for Opioid Use Disorder, 2019-2023. Savitz ST, Stevens MA, Nath B, D'Onofrio G, Melnick ER, Jeffery MM. Mayo Clin Proc Innov Qual Outcomes. 2024 Jun; 2024 May 24. PMID: 38841599.", + "Virtual Scribes and Physician Time Spent on Electronic Health Records. Rotenstein L, Melnick ER, Iannaccone C, Zhang J, Mugal A, Lipsitz SR, Healey MJ, Holland C, Snyder R, Sinsky CA, Ting D, Bates DW. JAMA Netw Open. 2024 May 1; 2024 May 1. PMID: 38787556.", + "Quantifying EHR and Policy Factors Associated with the Gender Productivity Gap in Ambulatory, General Internal Medicine. Li H, Rotenstein L, Jeffery MM, Paek H, Nath B, Williams BL, McLean RM, Goldstein R, Nuckols TK, Hoq L, Melnick ER. J Gen Intern Med. 2024 Mar; 2023 Oct 16. PMID: 37843702.", + "Formative evaluation of an emergency department clinical decision support system for agitation symptoms: a study protocol. Wong AH, Nath B, Shah D, Kumar A, Brinker M, Faustino IV, Boyce M, Dziura JD, Heckmann R, Yonkers KA, Bernstein SL, Adapa K, Taylor RA, Ovchinnikova P, McCall T, Melnick ER. BMJ Open. 2024 Feb 19; 2024 Feb 19. PMID: 38373857.", + "Why Do Physicians Depart Their Practice? A Qualitative Study of Attrition in a Multispecialty Ambulatory Practice Network. O'Connell R, Hosain F, Colucci L, Nath B, Melnick ER. J Am Board Fam Med. 2024 Jan 5; 2024 Jan 5. PMID: 37857441.", + "Structure and Funding of Clinical Informatics Fellowships: A National Survey of Program Directors. Patel TN, Chaise AJ, Hanna JJ, Patel KP, Kochendorfer KM, Medford RJ, Mize DE, Melnick ER, Hron JD, Youens K, Pandita D, Leu MG, Ator GA, Yu F, Genes N, Baker CK, Bell DS, Pevnick JM, Conrad SA, Chandawarkar AR, Rogers KM, Kaelber DC, Singh IR, Levy BP, Finnell JT, Kannry J, Pageler NM, Mohan V, Lehmann CU. Appl Clin Inform. 2024 Jan; 2024 Jan 3. PMID: 38171383.", + "Association of Primary Care Physicians' Electronic Inbox Activity Patterns with Patients' Likelihood to Recommend the Physician. Rotenstein LS, Melnick ER, Jeffery M, Zhang J, Sinsky CA, Gitomer R, Bates DW. J Gen Intern Med. 2024 Jan; 2023 Sep 20. PMID: 37731135.", + "CT With CTA Versus MRI in Patients Presenting to the Emergency Department With Dizziness: Analysis Using Propensity Score Matching. Tu LH, Navaratnam D, Melnick ER, Forman HP, Venkatesh AK, Malhotra A, Yaesoubi R, Sureshanand S, Sheth KN, Mahajan A. AJR Am J Roentgenol. 2023 Dec; 2023 Jul 5. PMID: 37404082.", + "Adoption of Emergency Department-Initiated Buprenorphine for Patients With Opioid Use Disorder: Secondary Analysis of a Cluster Randomized Trial. Gao E, Melnick ER, Paek H, Nath B, Taylor RA, Loza AJ. JAMA Netw Open. 2023 Nov 1; 2023 Nov 1. PMID: 37948075.", + "Identifying and Addressing Barriers to Implementing Core Electronic Health Record Use Metrics for Ambulatory Care: Virtual Consensus Conference Proceedings. Levy DR, Moy AJ, Apathy N, Adler-Milstein J, Rotenstein L, Nath B, Rosenbloom ST, Kannampallil T, Mishuris RG, Alexanian A, Sieja A, Hribar MR, Patel JS, Sinsky CA, Melnick ER. Appl Clin Inform. 2023 Oct; 2023 Oct 6. PMID: 37802122.", + "Clinical Decision Support: Moving Beyond Interruptive \"Pop-up\" Alerts. Sangal RB, Sharifi M, Rhodes D, Melnick ER. Mayo Clin Proc. 2023 Sep. PMID: 37661138.", + "National trends in emergency conditions through the Omicron COVID-19 wave in commercial and Medicare Advantage enrollees. Stevens MA, Melnick ER, Savitz ST, Jeffery MM, Nath B, Janke AT. J Am Coll Emerg Physicians Open. 2023 Aug; 2023 Aug 12. PMID: 37576118.", + "Humans as an Essential Source of Safety: A Frameshift for System Resilience. Farley HL, Harry EM, Sinsky CA, Boehm EW, Privitera MR, Melnick ER. Mayo Clin Proc Innov Qual Outcomes. 2023 Aug; 2023 Jun 2. PMID: 37304062.", + "Fentanyl-Associated Overdose Deaths Outside the Hospital. Jeffery MM, Stevens M, D'Onofrio G, Melnick ER. N Engl J Med. 2023 Jul 6; 2023 Jun 21. PMID: 37342960.", + "Racial and ethnic disparities in emergency department-initiated buprenorphine across five health care systems. Holland WC, Li F, Nath B, Jeffery MM, Stevens M, Melnick ER, Dziura JD, Khidir H, Skains RM, D'Onofrio G, Soares WE 3rd. Acad Emerg Med. 2023 Jul; 2023 Feb 27. PMID: 36660800.", + "Implementation strategies to address the determinants of adoption, implementation, and maintenance of a clinical decision support tool for emergency department buprenorphine initiation: a qualitative study. Simpson MJ, Ritger C, Hoppe JA, Holland WC, Morris MA, Nath B, Melnick ER, Tietbohl C. Implement Sci Commun. 2023 Apr 20; 2023 Apr 20. PMID: 37081581.", + "Funding Research on Health Workforce Well-being to Optimize the Work Environment. Melnick ER, Sinsky CA, Shanafelt T. JAMA. 2023 Apr 11. PMID: 36821127.", + "Predicting physician departure with machine learning on EHR use patterns: A longitudinal cohort from a large multi-specialty ambulatory practice. Lopez K, Li H, Paek H, Williams B, Nath B, Melnick ER, Loza AJ. PLoS One. 2023; 2023 Feb 1. PMID: 36724149.", + "Paging the Clinical Informatics Community: Respond STAT to Dobbs v. Jackson's Women's Health Organization. Arvisais-Anhalt S, Ravi A, Weia B, Aarts J, Ahmad HB, Araj E, Bauml JA, Benham-Hutchins M, Boyd AD, Brecht-Doscher A, Butler-Henderson K, Butte AJ, Cardilo AB, Chilukuri N, Cho MK, Cohen JK, Craven CK, Crusco S, Dadabhoy F, Dash D, DeBolt C, Elkin PL, Fayanju OA, Fochtmann LJ, Graham JV, Hanna JJ, Hersh W, Hofford MR, Hron JD, Huang SS, Jackson BR, Kaplan B, Kelly W, Ko K, Koppel R, Kurapati N, Labbad G, Lee JJ, Lehmann CU, Leitner S, Liao ZC, Medford RJ, Melnick ER, Muniyappa AN, Murray SG, Neinstein AB, Nichols-Johnson V, Novak LL, Ogan WS, Ozeran L, Pageler NM, Pandita D, Perumbeti A, Petersen C, Pierce L, Puttagunta R, Ramaswamy P, Rogers KM, Rosenbloom ST, Ryan A, Saleh S, Sarabu C, Schreiber R, Shaw KA, Sim I, Sirintrapun SJ, Solomonides A, Spector JD, Starren JB, Stoffel M, Subbian V, Swanson K, Tomes A, Trang K, Unertl KM, Weon JL, Whooley MA, Wiley K, Williamson DFK, Winkelstein P, Wong J, Xie J, Yarahuan JKW, Yung N, Zera C, Ratanawongsa N, Sadasivaiah S. Appl Clin Inform. 2023 Jan; 2022 Dec 19. PMID: 36535703.", + "Using event logs to observe interactions with electronic health records: an updated scoping review shows increasing use of vendor-derived measures. Rule A, Melnick ER, Apathy NC. J Am Med Inform Assoc. 2022 Dec 13. PMID: 36173361.", + "Restoring Meaningful Content to the Medical Record: Standardizing Measurement Could Improve EHR Utility While Decreasing Burden. Iscoe MS, McLean RM, Melnick ER. Mayo Clin Proc. 2022 Nov; 2022 Oct 7. PMID: 36210197.", + "Emergency physicians' EHR use across hospitals: A cross-sectional analysis. Iscoe MS, Holland ML, Paek H, Flood C, Melnick ER. Am J Emerg Med. 2022 Nov; 2022 Jul 9. PMID: 35842301.", + "Pragmatic clinical trial design in emergency medicine: Study considerations and design types. Gettel CJ, Yiadom MYAB, Bernstein SL, Grudzen CR, Nath B, Li F, Hwang U, Hess EP, Melnick ER. Acad Emerg Med. 2022 Oct; 2022 May 22. PMID: 35475533.", + "Monthly Rates of Patients Who Left Before Accessing Care in US Emergency Departments, 2017-2021. Janke AT, Melnick ER, Venkatesh AK. JAMA Netw Open. 2022 Sep 1; 2022 Sep 1. PMID: 36178693.", + "Hospital Occupancy and Emergency Department Boarding During the COVID-19 Pandemic. Janke AT, Melnick ER, Venkatesh AK. JAMA Netw Open. 2022 Sep 1; 2022 Sep 1. PMID: 36178691.", + "User centered clinical decision support to implement initiation of buprenorphine for opioid use disorder in the emergency department: EMBED pragmatic cluster randomized controlled trial. Melnick ER, Nath B, Dziura JD, Casey MF, Jeffery MM, Paek H, Soares WE 3rd, Hoppe JA, Rajeevan H, Li F, Skains RM, Walter LA, Patel MD, Chari SV, Platts-Mills TF, Hess EP, D'Onofrio G. BMJ. 2022 Jun 27; 2022 Jun 27. PMID: 35760423.", + "A Learning Health System Agenda for Organizational Approaches to Enhancing Occupational Well-being Among Clinicians. Rotenstein LS, Melnick ER, Sinsky CA. JAMA. 2022 Jun 7. PMID: 35551325.", + "Trends and Disparities in Access to Buprenorphine Treatment Following an Opioid-Related Emergency Department Visit Among an Insured Cohort, 2014-2020. Stevens MA, Tsai J, Savitz ST, Nath B, Melnick ER, D'Onofrio G, Jeffery MM. JAMA Netw Open. 2022 Jun 1; 2022 Jun 1. PMID: 35657629.", + "Clinical decision support in cardiovascular medicine. Lu Y, Melnick ER, Krumholz HM. BMJ. 2022 May 25; 2022 May 25. PMID: 35613721.", + "Gender Differences in Time Spent on Documentation and the Electronic Health Record in a Large Ambulatory Network. Rotenstein LS, Fong AS, Jeffery MM, Sinsky CA, Goldstein R, Williams B, Melnick ER. JAMA Netw Open. 2022 Mar 1; 2022 Mar 1. PMID: 35323954.", + "In reply. D'Onofrio G, Melnick ER, Hawk KF. Ann Emerg Med. 2022 Feb. PMID: 35065746.", + "Pilot MRI-based strategies to improve the detection of stroke in patients with dizziness/vertigo. Tu LH, Mahajan A, Minja FJ, Navaratnam D, Melnick ER. Clin Imaging. 2022 Feb; 2021 Dec 9. PMID: 34902799.", + "Emergency Department Visits for Nonfatal Opioid Overdose During the COVID-19 Pandemic Across Six US Health Care Systems. Soares WE 3rd, Melnick ER, Nath B, D'Onofrio G, Paek H, Skains RM, Walter LA, Casey MF, Napoli A, Hoppe JA, Jeffery MM. Ann Emerg Med. 2022 Feb; 2021 Mar 19. PMID: 34119326.", + "Trends in Electronic Health Record Inbox Messaging During the COVID-19 Pandemic in an Ambulatory Practice Network in New England. Nath B, Williams B, Jeffery MM, O'Connell R, Goldstein R, Sinsky CA, Melnick ER. JAMA Netw Open. 2021 Oct 1; 2021 Oct 1. PMID: 34636917.", + "Analysis of Electronic Health Record Use and Clinical Productivity and Their Association With Physician Turnover. Melnick ER, Fong A, Nath B, Williams B, Ratwani RM, Goldstein R, O'Connell RT, Sinsky CA, Marchalik D, Mete M. JAMA Netw Open. 2021 Oct 1; 2021 Oct 1. PMID: 34636911.", + "Improve Access to Care for Opioid Use Disorder: A Call to Eliminate the X-Waiver Requirement Now. D'Onofrio G, Melnick ER, Hawk KF. Ann Emerg Med. 2021 Aug; 2021 May 7. PMID: 33966933.", + "The association between perceived electronic health record usability and professional burnout among US nurses. Melnick ER, West CP, Nath B, Cipriano PF, Peterson C, Satele DV, Shanafelt T, Dyrbye LN. J Am Med Inform Assoc. 2021 Jul 30. PMID: 33871018.", + "Characterizing physician EHR use with vendor derived data: a feasibility study and cross-sectional analysis. Melnick ER, Ong SY, Fong A, Socrates V, Ratwani RM, Nath B, Simonov M, Salgia A, Williams B, Marchalik D, Goldstein R, Sinsky CA. J Am Med Inform Assoc. 2021 Jul 14. PMID: 33822970.", + "Accounting for quality improvement during the conduct of embedded pragmatic clinical trials within healthcare systems: NIH Collaboratory case studies. Tuzzio L, Meyers CM, Dember LM, Grudzen CR, Melnick ER, Staman KL, Huang SS, Richards J, DeBar L, Vazquez MA, Green BB, Coronado GD, Jarvik JG, Braciszewski J, Ho PM, Wells BL, James K, Toto R, D'Onofrio G, Volandes A, Kuklinski MR, Catalano RF, Sterling SA, Morse EF, Curtis L, Larson EB. Healthc (Amst). 2021 Jun; 2021 Jun 23. PMID: 34175091.", + "Implementing Measurement Science for Electronic Health Record Use. Melnick ER, Sinsky CA, Krumholz HM. JAMA. 2021 Jun 1. PMID: 33818587.", + "Advancing electronic health record vendor usability maturity: Progress and next steps. Hettinger AZ, Melnick ER, Ratwani RM. J Am Med Inform Assoc. 2021 Apr 23. PMID: 33517394.", + "Mixed-effects models for the design and analysis of stepped wedge cluster randomized trials: An overview. Li F, Hughes JP, Hemming K, Taljaard M, Melnick ER, Heagerty PJ. Stat Methods Med Res. 2021 Feb; 2020 Jul 6. PMID: 32631142.", + "Perceived Electronic Health Record Usability as a Predictor of Task Load and Burnout Among US Physicians: Mediation Analysis. Melnick ER, Harry E, Sinsky CA, Dyrbye LN, Wang H, Trockel MT, West CP, Shanafelt T. J Med Internet Res. 2020 Dec 22; 2020 Dec 22. PMID: 33289493.", + "Adapting two American Decision Aids for Mild Traumatic Brain Injury to the Canadian Context Using the Nominal Group Technique. Ghandour EK, Lelaidier Hould L, Fortier FA, Gélinas V, Melnick ER, Hess EP, Lang ES, Gravel J, Perry JJ, Le Sage N, Truchon C, LeBlanc A, Dubrovsky AS, Gagnon MP, Ouellet MC, Gagnon I, McKenna S, Légaré F, Sauvé L, van de Belt TH, Kavanagh É, Paquette L, Verrette AC, Plante P, Riopelle RJ, Archambault PM. Patient. 2020 Dec; 2020 Oct 20. PMID: 33078377.", + "Trends in Emergency Department Visits and Hospital Admissions in Health Care Systems in 5 States in the First Months of the COVID-19 Pandemic in the US. Jeffery MM, D'Onofrio G, Paek H, Platts-Mills TF, Soares WE 3rd, Hoppe JA, Genes N, Nath B, Melnick ER. JAMA Intern Med. 2020 Oct 1. PMID: 32744612.", + "Interrupted Time Series of User-centered Clinical Decision Support Implementation for Emergency Department-initiated Buprenorphine for Opioid Use Disorder. Holland WC, Nath B, Li F, Maciejewski K, Paek H, Dziura J, Rajeevan H, Lu CC, Katsovich L, D'Onofrio G, Melnick ER. Acad Emerg Med. 2020 Aug; 2020 May 19. PMID: 32352206.", + "Should governments continue lockdown to slow the spread of covid-19? Melnick ER, Ioannidis JPA. BMJ. 2020 Jun 3; 2020 Jun 3. PMID: 32493767.", + "Association of Perceived Electronic Health Record Usability With Patient Interactions and Work-Life Integration Among US Physicians. Melnick ER, Sinsky CA, Dyrbye LN, Trockel M, West CP, Nedelec L, Shanafelt T. JAMA Netw Open. 2020 Jun 1; 2020 Jun 1. PMID: 32568397.", + "Tolerance of Uncertainty and the Practice of Emergency Medicine. Platts-Mills TF, Nagurney JM, Melnick ER. Ann Emerg Med. 2020 Jun; 2019 Dec 23. PMID: 31874767.", + "Covid-19 fatality is likely overestimated. Niforatos JD, Melnick ER, Faust JS. BMJ. 2020 Mar 20; 2020 Mar 20. PMID: 32198267.", + "The Association Between Perceived Electronic Health Record Usability and Professional Burnout Among US Physicians. Melnick ER, Dyrbye LN, Sinsky CA, Trockel M, West CP, Nedelec L, Tutty MA, Shanafelt T. Mayo Clin Proc. 2020 Mar; 2019 Nov 14. PMID: 31735343.", + "Head CT overuse in children with a mild traumatic brain injury within two Canadian emergency departments. Gariepy M, Gravel J, Légaré F, Melnick ER, Hess EP, Witteman HO, Lelaidier-Hould L, Truchon C, Sauvé L, Plante P, Le Sage N, Archambault PM. Paediatr Child Health. 2020 Feb; 2019 Jan 14. PMID: 33390737.", + "Progress Report on EMBED: A Pragmatic Trial of User-Centered Clinical Decision Support to Implement EMergency Department-Initiated BuprenorphinE for Opioid Use Disorder. Melnick ER, Nath B, Ahmed OM, Brandt C, Chartash D, Dziura JD, Hess EP, Holland WC, Hoppe JA, Jeffery MM, Katsovich L, Li F, Lu CC, Maciejewski K, Maleska M, Mao JA, Martel S, Michael S, Paek H, Patel MD, Platts-Mills TF, Rajeevan H, Ray JM, Skains RM, Soares WE 3rd, Deutsch A, Solad Y, D'Onofrio G. J Psychiatr Brain Sci. 2020; 2020 Feb 21. PMID: 32309637.", + "Opportunities for addressing gaps in primary care shared decision-making with technology: a mixed-methods needs assessment. Misra AJ, Ong SY, Gokhale A, Khan S, Melnick ER. JAMIA Open. 2019 Dec; 2019 Jul 31. PMID: 32025641.", + "An integrated web application for decision support and automation of EHR workflow: a case study of current challenges to standards-based messaging and scalability from the EMBED trial. Melnick ER, Holland WC, Ahmed OM, Ma AK, Michael SS, Goldberg HS, Lagier C, D'Onofrio G, Stachowiak T, Brandt C, Solad Y. JAMIA Open. 2019 Dec; 2019 Oct 14. PMID: 32025639.", + "Six habits of highly successful health information technology: powerful strategies for design and implementation. Ray JM, Ratwani RM, Sinsky CA, Frankel RM, Friedberg MW, Powsner SM, Rosenthal DI, Wachter RM, Melnick ER. J Am Med Inform Assoc. 2019 Oct 1. PMID: 31265064.", + "A scalable, automated warm handoff from the emergency department to community sites offering continued medication for opioid use disorder: Lessons learned from the EMBED trial stakeholders. Ahmed OM, Mao JA, Holt SR, Hawk K, D'Onofrio G, Martel S, Melnick ER. J Subst Abuse Treat. 2019 Jul; 2019 May 7. PMID: 31202288.", + "Treatment-Related Complications of Systemic Therapy and Radiotherapy. Jairam V, Lee V, Park HS, Thomas CR Jr, Melnick ER, Gross CP, Presley CJ, Adelson KB, Yu JB. JAMA Oncol. 2019 Jul 1. PMID: 30946433.", + "User-centred clinical decision support to implement emergency department-initiated buprenorphine for opioid use disorder: protocol for the pragmatic group randomised EMBED trial. Melnick ER, Jeffery MM, Dziura JD, Mao JA, Hess EP, Platts-Mills TF, Solad Y, Paek H, Martel S, Patel MD, Bankowski L, Lu C, Brandt C, D'Onofrio G. BMJ Open. 2019 May 30; 2019 May 30. PMID: 31152039.", + "Computerized Clinical Decision Support System for Emergency Department-Initiated Buprenorphine for Opioid Use Disorder: User-Centered Design. Ray JM, Ahmed OM, Solad Y, Maleska M, Martel S, Jeffery MM, Platts-Mills TF, Hess EP, D'Onofrio G, Melnick ER. JMIR Hum Factors. 2019 Feb 27; 2019 Feb 27. PMID: 30810531.", + "An appraisal of emergency medicine clinical practice guidelines: Do we agree? Zupon A, Rothenberg C, Couturier K, Tan TX, Siddiqui G, James M, Savage D, Melnick ER, Venkatesh AK. Int J Clin Pract. 2019 Feb; 2018 Nov 14. PMID: 30372798.", + "Applicability of the Canadian CT Head Rule in Minimal Head Injury. Tran KA, Melnick ER, Raja AS, Sharp AL, Trottier MÈ, Archambault PM. Ann Emerg Med. 2019 Jan. PMID: 30577964.", + "Efficacy and unintended consequences of hard-stop alerts in electronic health record systems: a systematic review. Powers EM, Shiffman RN, Melnick ER, Hickner A, Sharifi M. J Am Med Inform Assoc. 2018 Nov 1. PMID: 30239810.", + "Cross-sectional study of the association between healthcare professionals' empathy and burnout and the number of annual primary care visits per patient under their care in Spain. Yuguero O, Melnick ER, Marsal JR, Esquerda M, Soler-Gonzalez J. BMJ Open. 2018 Jul 30; 2018 Jul 30. PMID: 30061437.", + "Optimizing recruitment and retention of adolescents in ED research: Findings from concussion biomarker pilot study. Mbachu SN, Pieribone VA, Bechtel KA, McCarthy ML, Melnick ER. Am J Emerg Med. 2018 May; 2017 Sep 14. PMID: 28918968.", + "Implementation of the Canadian CT Head Rule and Its Association With Use of Computed Tomography Among Patients With Head Injury. Sharp AL, Huang BZ, Tang T, Shen E, Melnick ER, Venkatesh AK, Kanter MH, Gould MK. Ann Emerg Med. 2018 Jan; 2017 Jul 21. PMID: 28739290.", + "Shared Decisionmaking in the Emergency Department: A Guiding Framework for Clinicians. Probst MA, Kanzaria HK, Schoenfeld EM, Menchine MD, Breslin M, Walsh C, Melnick ER, Hess EP. Ann Emerg Med. 2017 Nov; 2017 May 27. PMID: 28559034.", + "In Reply-Defining Physician Burnout, and Differentiating Between Burnout and Depression. Melnick ER, Powsner SM, Shanafelt TD. Mayo Clin Proc. 2017 Sep. PMID: 28870365.", + "Patient-Centered Decision Support: Formative Usability Evaluation of Integrated Clinical Decision Support With a Patient Decision Aid for Minor Head Injury in the Emergency Department. Melnick ER, Hess EP, Guo G, Breslin M, Lopez K, Pavlo AJ, Abujarad F, Powsner SM, Post LA. J Med Internet Res. 2017 May 19; 2017 May 19. PMID: 28526667.", + "Big Versus Small Data and the Generalizability of the Rate of Computed Tomography Overuse in Minor Head Injury. Melnick ER. Acad Emerg Med. 2017 Mar. PMID: 27617902.", + "Empathy in the Time of Burnout. Melnick ER, Powsner SM. Mayo Clin Proc. 2016 Dec; 2016 Nov 8. PMID: 27836111.", + "Development and Testing of Shared Decision Making Interventions for Use in Emergency Care: A Research Agenda. Melnick ER, Probst MA, Schoenfeld E, Collins SP, Breslin M, Walsh C, Kuppermann N, Dunn P, Abella BS, Boatright D, Hess EP. Acad Emerg Med. 2016 Dec. PMID: 27457137.", + "The Association Between Physician Empathy and Variation in Imaging Use. Melnick ER, O'Brien EG, Kovalerchik O, Fleischman W, Venkatesh AK, Taylor RA. Acad Emerg Med. 2016 Aug; 2016 Aug 1. PMID: 27343485.", + "Financial Ties Between Emergency Physicians and Industry: Insights From Open Payments Data. Fleischman W, Ross JS, Melnick ER, Newman DH, Venkatesh AK. Ann Emerg Med. 2016 Aug; 2016 Mar 10. PMID: 26973175.", + "Prediction of In-hospital Mortality in Emergency Department Patients With Sepsis: A Local Big Data-Driven, Machine Learning Approach. Taylor RA, Pare JR, Venkatesh AK, Mowafi H, Melnick ER, Fleischman W, Hall MK. Acad Emerg Med. 2016 Mar; 2016 Feb 13. PMID: 26679719.", + "Comparative Effectiveness Research: Alternatives to \"Traditional\" Computed Tomography Use in the Acute Care Setting. Moore CL, Broder J, Gunn ML, Bhargavan-Chatfield M, Cody D, Cullison K, Daniels B, Gans B, Kennedy Hall M, Gaines BA, Goldman S, Heil J, Liu R, Marin JR, Melnick ER, Novelline RA, Pare J, Repplinger MD, Taylor RA, Sodickson AD. Acad Emerg Med. 2015 Dec; 2015 Nov 17. PMID: 26576033.", + "Understanding Overuse of Computed Tomography for Minor Head Injury in the Emergency Department: A Triangulated Qualitative Study. Melnick ER, Shafer K, Rodulfo N, Shi J, Hess EP, Wears RL, Qureshi RA, Post LA. Acad Emerg Med. 2015 Dec; 2015 Nov 14. PMID: 26568523.", + "Improving emergency physician performance using audit and feedback: a systematic review. Le Grand Rogers R, Narvaez Y, Venkatesh AK, Fleischman W, Hall MK, Taylor RA, Hersey D, Sette L, Melnick ER. Am J Emerg Med. 2015 Oct; 2015 Jul 23. PMID: 26296903.", + "Redefining Overuse to Include Costs: A Decision Analysis for Computed Tomography in Minor Head Injury. Melnick ER, Keegan J, Taylor RA. Jt Comm J Qual Patient Saf. 2015 Jul. PMID: 26108124.", + "Back to the Bedside: Developing a Bedside Aid for Concussion and Brain Injury Decisions in the Emergency Department. Melnick ER, Lopez K, Hess EP, Abujarad F, Brandt CA, Shiffman RN, Post LA. EGEMS (Wash DC). 2015; 2015 Jun 29. PMID: 26290885.", + "CT overuse for mild traumatic brain injury. Melnick ER, Szlezak CM, Bentley SK, Dziura JD, Kotlyar S, Post LA. Jt Comm J Qual Patient Saf. 2012 Nov. PMID: 23173394.", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Addy Lab", + "lab_url": "https://medicine.yale.edu/lab/addy/", + "research_bio": "INFORMATION FOR Our research examines the neurobiological mechanisms of reinforcement learning and motivational control and seeks to identify how these mechanisms are altered in psychiatric illnesses, such as substance abuse. In this work, we use an integrative methodological approach that incorporates in vivo electrochemistry (fast scan cyclic voltammetry), in vivo optogenetics and preclinical behavioral analyses. We are currently investigating the neurobiological processes that underlie the ability of reward-associated cues to modulate ongoing behavior. Our recent findings show that midbrain cholinergic mechanisms powerfully regulate cue-induced cocaine-seeking behavior and suggest that cholinergic receptor modulation of phasic dopamine signaling may be critical for this behavior. Through ongoing projects, we are continuing to examine the role of cholinergic and dopaminergic mechanisms in cue-induced drug-seeking. In other work, we are investigating phasic dopamine mechanisms in nicotine addiction and the potential ability of tobacco product additives to enhance nicotine reinforcement through the regulation of dopamine signaling. In addition to our drug addiction research, we are also determining the role of cholinergic and dopaminergic mechanisms in other psychiatric illnesses, such as major depressive disorder (MDD). The goals of our research are to provide new insight into the mechanistic basis of these complex behaviors and to identify novel therapeutic targets to treat psychiatric disorders. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/addy/publications/", + "publications": [ + "Yale School of Medicine /", + "Psychiatry /", + "People", + "The Addy Hour", + "Publications", + "Links", + "News", + "Video", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "People", + "Publications", + "News", + "Video", + "The Addy Hour", + "Links", + "", + "", + "", + "", + "", + "", + "L-type calcium channel blockade attenuates cue-induced cocaine-seeking in female rats. Kimble VM, Nunes EJ, Rajadhyaksha AM, Addy NA. Behav Brain Res. 2025 Jul 26; 2025 May 3. PMID: 40324598.", + "Preclinical Evidence of the Effects of Sweet Flavors: Sweetness Increases Nicotine Intake and Seeking. Bagdas D, Addy NA. Nicotine Tob Res. 2025 Mar 24. PMID: 39413033.", + "Effects of Sweeteners and Cinnamon Flavor on Oral Nicotine Choice Behaviors. Bagdas D, Sedaille J, Khan M, Okpala N, Addy NA. Nicotine Tob Res. 2025 Mar 18; 2025 Mar 18. PMID: 40097606.", + "L-type calcium channel blockade attenuates the anxiogenic-like effects of cocaine abstinence in female and male rats. Nunes EJ, Kimble V, Rajadhyaksha AM, Addy NA. Neuroscience. 2025 Mar 5; 2025 Jan 4. PMID: 39761823.", + "Workplace bullying among medical laboratory professionals in Ghana: insights from self-reported experiences, challenges to mitigation structures, and coping strategies. Duah E, Ephraim RKD, Kotam GP, Kumordzi SM, Amoah S, Addy NA, Kwashie SDY, Rahamani AA. BMC Health Serv Res. 2025 Feb 25; 2025 Feb 25. PMID: 40001166.", + "Impact of vanilla flavor on nicotine taste, choice, intake, and seeking behaviors. Bagdas D, Zepei AM, Harris L, Minanov K, Jimenez JL, Addy NA. Psychopharmacology (Berl). 2024 Nov; 2024 Jun 6. PMID: 38839631.", + "L-type calcium channel regulation of depression, anxiety and anhedonia-related behavioral phenotypes following chronic stress exposure. Nunes EJ, Kebede N, Rajadhyaksha AM, Addy NA. Neuropharmacology. 2024 Oct 1; 2024 Jun 12. PMID: 38871116.", + "Targeting the Actions of Muscarinic Receptors on Dopamine Systems: New Strategies for Treating Neuropsychiatric Disorders. Nunes EJ, Addy NA, Conn PJ, Foster DJ. Annu Rev Pharmacol Toxicol. 2024 Jan 23; 2023 Aug 9. PMID: 37552895.", + "The impact of racism on Black American mental health. Cogburn CD, Roberts SK, Ransome Y, Addy N, Hansen H, Jordan A. Lancet Psychiatry. 2024 Jan. PMID: 38101873.", + "The Biological Psychiatry Cover Art Initiative: Addressing the Underrepresentation of Black People on the Journal Cover Through a Series of Commissioned Artworks. Krystal JH, Imeh IN, Garces RP, Addy NA. Biol Psychiatry. 2024 Jan 1. PMID: 38030306.", + "Self-reported continuing professional development needs of medical laboratory professionals in Ghana. Essuman MA, Addy NA, Essien-Baidoo S, Donkoh IE, Botchway FA, Afrifa J, Agyeman P, Amaama LA, Amoah S, Sorvor FBK, Ephraim RKD. Hum Resour Health. 2023 Sep 12; 2023 Sep 12. PMID: 37700340.", + "Ventral Tegmental Area M5 Muscarinic Receptors Mediate Effort-Choice Responding and Nucleus Accumbens Dopamine in a Sex-Specific Manner . Nunes EJ, Kebede N, Haight JL, Foster DJ, Lindsley CW, Conn PJ, Addy NA. J Pharmacol Exp Ther. 2023 May; 2023 Feb 24. PMID: 36828630.", + "L-type calcium channel regulation of dopamine activity in the ventral tegmental area to nucleus accumbens pathway: Implications for substance use, mood disorders and co-morbidities. Nunes EJ, Addy NA. Neuropharmacology. 2023 Feb 15; 2022 Nov 19. PMID: 36414149.", + "Chronic oral nicotine exposure decreases aversive taste of nicotine, increases nicotine withdrawal and reinstatement, but cherry flavor does not alter nicotine's effects in adolescent rats. Bagdas D, Harris L, Addy NA. Neurosci Lett. 2023 Jan 10; 2022 Dec 5. PMID: 36476758.", + "Cholinergic and dopaminergic-mediated motivated behavior in healthy states and in substance use and mood disorders. Nunes EJ, Kebede N, Bagdas D, Addy NA. J Exp Anal Behav. 2022 May; 2022 Mar 14. PMID: 35286712.", + "Evaluation of Flavor Effects on Oral Nicotine Liking and/or Disliking Using the Taste Reactivity Test in Rats. Bagdas D, Rupprecht LE, Nunes EJ, Schillinger E, Immanuel JJ, Addy NA. Nicotine Tob Res. 2022 Mar 26. PMID: 34918123.", + "Animal Models to Investigate the Impact of Flavors on Nicotine Addiction and Dependence. Bagdas D, Kebede N, Zepei AM, Harris L, Minanov K, Picciotto MR, Addy NA. Curr Neuropharmacol. 2022. PMID: 35611777.", + "An ongoing saga of nicotine complexity and dopamine heterogeneity: Nicotine activation and inhibition mediating reward and anxiety. Addy NA. Neuron. 2021 Aug 18. PMID: 34411537.", + "Examining the role of muscarinic M5 receptors in VTA cholinergic modulation of depressive-like and anxiety-related behaviors in rats. Nunes EJ, Rupprecht LE, Foster DJ, Lindsley CW, Conn PJ, Addy NA. Neuropharmacology. 2020 Jul; 2020 Apr 5. PMID: 32268153.", + "Combined Infusion and Stimulation with Fast-Scan Cyclic Voltammetry (CIS-FSCV) to Assess Ventral Tegmental Area Receptor Regulation of Phasic Dopamine. Wickham RJ, Lehr M, Mitchell L, Addy NA. J Vis Exp. 2020 Apr 23; 2020 Apr 23. PMID: 32420985.", + "Cholinergic Receptor Blockade in the VTA Attenuates Cue-Induced Cocaine-Seeking and Reverses the Anxiogenic Effects of Forced Abstinence. Nunes EJ, Bitner L, Hughley SM, Small KM, Walton SN, Rupprecht LE, Addy NA. Neuroscience. 2019 Aug 10; 2019 Jul 2. PMID: 31271832.", + "Neurobiological and Neurophysiological Mechanisms Underlying Nicotine Seeking and Smoking Relapse. Schmidt HD, Rupprecht LE, Addy NA. Mol Neuropsychiatry. 2019 Feb; 2018 Nov 19. PMID: 30815453.", + "The L-type calcium channel blocker, isradipine, attenuates cue-induced cocaine-seeking by enhancing dopaminergic activity in the ventral tegmental area to nucleus accumbens pathway. Addy NA, Nunes EJ, Hughley SM, Small KM, Baracz SJ, Haight JL, Rajadhyaksha AM. Neuropsychopharmacology. 2018 Nov; 2018 May 3. PMID: 29773910.", + "Evaluating oral flavorant effects on nicotine self-administration behavior and phasic dopamine signaling. Wickham RJ, Nunes EJ, Hughley S, Silva P, Walton SN, Park J, Addy NA. Neuropharmacology. 2018 Jan; 2017 Sep 21. PMID: 28943284.", + "Enhancing VTA Ca(v)1.3 L-type Ca(2+) channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens. Martínez-Rivera A, Hao J, Tropea TF, Giordano TP, Kosovsky M, Rice RC, Lee A, Huganir RL, Striessnig J, Addy NA, Han S, Rajadhyaksha AM. Mol Psychiatry. 2017 Dec; 2017 Feb 14. PMID: 28194001.", + "Vitamin D3: A Role in Dopamine Circuit Regulation, Diet-Induced Obesity, and Drug Consumption. Trinko JR, Land BB, Solecki WB, Wickham RJ, Tellez LA, Maldonado-Aviles J, de Araujo IE, Addy NA, DiLeone RJ. eNeuro. 2016 Mar-Apr; 2016 May 19. PMID: 27257625.", + "Ventral tegmental area muscarinic receptors modulate depression and anxiety-related behaviors in rats. Small KM, Nunes E, Hughley S, Addy NA. Neurosci Lett. 2016 Mar 11; 2016 Jan 29. PMID: 26828299.", + "Muscarinic, but not nicotinic, acetylcholine receptor blockade in the ventral tegmental area attenuates cue-induced sucrose-seeking. Addy NA, Nunes EJ, Wickham RJ. Behav Brain Res. 2015 Sep 15; 2015 May 28. PMID: 26026787.", + "Distinct effects of ventral tegmental area NMDA and acetylcholine receptor blockade on conditioned reinforcement produced by food-associated cues. Wickham RJ, Solecki WB, Nunes EJ, Addy NA. Neuroscience. 2015 Aug 20; 2015 Jun 17. PMID: 26093048.", + "Examination of Rapid Dopamine Dynamics with Fast Scan Cyclic Voltammetry During Intra-oral Tastant Administration in Awake Rats. Wickham RJ, Park J, Nunes EJ, Addy NA. J Vis Exp. 2015 Aug 12; 2015 Aug 12. PMID: 26325447.", + "Ventral tegmental area cholinergic mechanisms mediate behavioral responses in the forced swim test. Addy NA, Nunes EJ, Wickham RJ. Behav Brain Res. 2015 Jul 15; 2015 Apr 9. PMID: 25865152.", + "Repeated nicotine exposure during adolescence alters reward-related learning in male and female rats. Quick SL, Olausson P, Addy NA, Taylor JR. Behav Brain Res. 2014 Mar 15; 2013 Dec 12. PMID: 24333376.", + "Differential role of ventral tegmental area acetylcholine and N-methyl-D-aspartate receptors in cocaine-seeking. Solecki W, Wickham RJ, Behrens S, Wang J, Zwerling B, Mason GF, Addy NA. Neuropharmacology. 2013 Dec; 2013 Jul 11. PMID: 23850572.", + "Ventral tegmental area α6β2 nicotinic acetylcholine receptors modulate phasic dopamine release in the nucleus accumbens core. Wickham R, Solecki W, Rathbun L, McIntosh JM, Addy NA. Psychopharmacology (Berl). 2013 Sep; 2013 Apr 30. PMID: 23624852.", + "Advances in studying phasic dopamine signaling in brain reward mechanisms. Wickham RJ, Solecki W, Rathbun LR, Neugebauer NM, Wightman RM, Addy NA. Front Biosci (Elite Ed). 2013 Jun 1; 2013 Jun 1. PMID: 23747914.", + "Nicotine, striatum, and reward. Addy NA, Picciotto MR. Biol Psychiatry. 2013 Feb 1. PMID: 23337022.", + "Sensitization of rapid dopamine signaling in the nucleus accumbens core and shell after repeated cocaine in rats. Addy NA, Daberkow DP, Ford JN, Garris PA, Wightman RM. J Neurophysiol. 2010 Aug; 2010 Jun 16. PMID: 20554845.", + "Administration of the calcineurin inhibitor cyclosporine modulates cocaine-induced locomotor activity in rats. Addy NA, Bahi A, Taylor JR, Picciotto MR. Psychopharmacology (Berl). 2008 Sep; 2008 Jun 28. PMID: 18587562.", + "It is not \"either/or\": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood. Picciotto MR, Addy NA, Mineur YS, Brunzell DH. Prog Neurobiol. 2008 Apr; 2007 Dec 27. PMID: 18242816.", + "Role of calcineurin in nicotine-mediated locomotor sensitization. Addy NA, Fornasiero EF, Stevens TR, Taylor JR, Picciotto MR. J Neurosci. 2007 Aug 8. PMID: 17687035.", + "Reversal of clozapine effects on working memory in rats with fimbria-fornix lesions. Addy NA, Pocivavsek A, Levin ED. Neuropsychopharmacology. 2005 Jun. PMID: 15688087.", + "Impaired synaptic plasticity and learning in mice lacking beta-adducin, an actin-regulating protein. Rabenstein RL, Addy NA, Caldarone BJ, Asaka Y, Gruenbaum LM, Peters LL, Gilligan DM, Fitzsimonds RM, Picciotto MR. J Neurosci. 2005 Feb 23. PMID: 15728854.", + "Ventral hippocampal NMDA blockade and nicotinic effects on memory function. Levin ED, Sledge D, Baruah A, Addy NA. Brain Res Bull. 2003 Sep 30. PMID: 13679247.", + "Nicotinic mechanisms of memory: effects of acute local DHbetaE and MLA infusions in the basolateral amygdala. Addy NA, Nakijama A, Levin ED. Brain Res Cogn Brain Res. 2003 Mar. PMID: 12589888.", + "Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations. Levin ED, Addy N, Baruah A, Elias A, Christopher NC, Seidler FJ, Slotkin TA. Neurotoxicol Teratol. 2002 Nov-Dec. PMID: 12460655.", + "Nicotine interactions with haloperidol, clozapine and risperidone and working memory function in rats. Addy N, Levin ED. Neuropsychopharmacology. 2002 Oct. PMID: 12377390.", + "Hippocampal alpha 7 and alpha 4 beta 2 nicotinic receptors and working memory. Levin ED, Bradley A, Addy N, Sigurani N. Neuroscience. 2002. PMID: 11927157.", + "Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. Levin ED, Addy N, Nakajima A, Christopher NC, Seidler FJ, Slotkin TA. Brain Res Dev Brain Res. 2001 Sep 23. PMID: 11557096.", + "300 George Street New Haven, CT 06511", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Adversity, Brain, Novel Therapeutics (ABN) Lab", + "lab_url": "https://medicine.yale.edu/lab/abn/", + "research_bio": "INFORMATION FOR At Yale’s Dr. Anahita Bassir Nia Laboratory (ABN Lab), our research aims to find novel treatments for stress-related disorders such as post-traumatic stress disorder (PTSD) and substance use disorders. We are interested in translational research to use evidence from preclinical studies and understand the underlying neurobiology of PTSD and addiction. We conduct various studies, including human laboratory experiments, brain imaging, and clinical trials.Questions We Seek to Answer: Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/abn/publications", + "publications": [ + "Yale School of Medicine /", + "Psychiatry /", + "Research/Projects", + "People", + "Publications", + "Clinical Trials", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research/Projects", + "People", + "Publications", + "Clinical Trials", + "", + "", + "", + "", + "", + "", + "Cannabinoid 1 receptor availability in posttraumatic stress disorder: A positron emission tomography study Korem N , Bassir Nia A , Hillmer A , D’Souza D , Nabulsi N , Ropchan J , Huang Y , Cosgrove K , Levy I , Pietrzak R , Harpaz-Rotem I . Cannabinoid 1 receptor availability in posttraumatic stress disorder: A positron emission tomography study . Translational Psychiatry 2025, 15: 310. PMID: 40846835 , PMCID: PMC12373994 , DOI: 10.1038/s41398-025-03519-9 . Books Altmetric Concepts Pathophysiology of posttraumatic stress disorder Emotional numbing symptoms CB1R availability Posttraumatic stress disorder Endocannabinoid system Stress disorder Positron emission tomography Trauma-exposed participants Endocannabinoid system's role Positron emission tomography studies Cannabinoid receptor 1 Emission tomography studies Multi-faceted disorder Fear learning CB1R Symptom expression Healthy controls Cannabinoid Disorders Tomography studies Emission tomography Preclinical studies Symptoms Higher levels Receptor 1", + "The Potential Use of Cannabidiol in the Treatment of Opioid Use Disorder: A Systematic Review Shafie M, Ing K, Rostam‐Abadi Y , Weleff J , Griffin M, Ranganathan M , Aghaei A, Pratt N, Funaro M , Nia A . The Potential Use of Cannabidiol in the Treatment of Opioid Use Disorder: A Systematic Review . Addiction Biology 2025, 30: e70047. PMID: 40415392 , PMCID: PMC12104536 , DOI: 10.1111/adb.70047 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Cannabidiol Craving Humans Opioid-Related Disorders Substance Withdrawal Syndrome Concepts Opioid use disorder OUD outcomes Use disorder Conditioned place preference paradigm Place preference paradigm Reducing withdrawal symptoms Potential of cannabidiol Substance use disorders Efficacy of cannabidiol Treatment of opioid use disorder Preclinical studies Clinical studies Opioid use disorder treatment Preference paradigm Anxiety symptoms Withdrawal symptoms Psychiatric disorders Effective treatment approach Treatment options Human studies Cannabidiol Animal studies Systematic review Short-term follow-up Craving", + "611. Cannabinoid 1 Receptor Availability in Men With Opioid Use Disorder: A Positron Emission Tomography Study Nia A , Hillmer A , Aghaei A, Pittman B , Huang H, Nabulsi N , D'Souza D . 611. Cannabinoid 1 Receptor Availability in Men With Opioid Use Disorder: A Positron Emission Tomography Study . Biological Psychiatry 2025, 97: s350. DOI: 10.1016/j.biopsych.2025.02.850 . Peer-Reviewed Original Research Concepts Positron emission tomography studies Emission tomography studies Opioid use disorder Use disorder Tomography studies Cannabinoid Disorders Opioid Positron Men", + "The therapeutic effects of psychedelics for opioid use disorder: A systematic review of clinical studies Weleff J , Pulido-Saavedra A, Aghaei A, Ing K, Arakelian M, Fontenele R, Nero N, Barnett B, Anand A, Bassir Nia A , Angarita G. The therapeutic effects of psychedelics for opioid use disorder: A systematic review of clinical studies . Psychiatry Research 2025, 348: 116446. PMID: 40147088 , PMCID: PMC12306858 , DOI: 10.1016/j.psychres.2025.116446 . Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements Altmetric Concepts Opioid use disorder Studies of psychedelics Systematic review of clinical studies Use disorder Review of clinical studies Therapeutic effects of psychedelics Effects of psychedelics Opioid receptor system Applications of psychedelics Clinical studies Mu-opioid receptors Naturalistic study Serotonergic psychedelics Opioid withdrawal Placebo-controlled trial Psychedelics Substance use United States Food and Drug Administration States Food and Drug Administration Mu-opioid Food and Drug Administration Systematic review Receptor system Clinical study design Double-blind", + "The Contribution of Psychotherapy in Potential Therapeutic Effects of Psychedelics for Treatment of Opioid Use Disorder Bassir Nia A , Farahmand Y, Griffith G, Ardavan M, Angarita G, Anand A, Pittenger C . The Contribution of Psychotherapy in Potential Therapeutic Effects of Psychedelics for Treatment of Opioid Use Disorder . Current Addiction Reports 2025, 12: 20. DOI: 10.1007/s40429-025-00638-7 . Peer-Reviewed Original Research Altmetric Concepts Effects of psychedelics Opioid use disorder Concurrent psychotherapy Use disorder Therapeutic effects of psychedelics Contribution of psychotherapy Impact of psychedelics Substance use disorders Opioid withdrawal symptoms Treatment of opioid use disorder FDA-approved medications Opioid use disorder treatment Psychotherapy modalities Psychedelic treatment Psychotherapy component Withdrawal symptoms Psychotherapy Psychedelic trials Therapy model Psychedelics Acute effects Disorders Associated with higher rates Treatment discontinuation Potential therapeutic effects", + "Effects of psychedelics on opioid use disorder: a scoping review of preclinical studies Pulido-Saavedra A, Oliva H, Prudente T , Kitaneh R, Nunes E , Fogg C, Funaro M , Weleff J , Nia A , Angarita G. Effects of psychedelics on opioid use disorder: a scoping review of preclinical studies . Cellular And Molecular Life Sciences 2025, 82: 49. PMID: 39833376 , PMCID: PMC11747050 , DOI: 10.1007/s00018-024-05519-2 . Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements Citations MeSH Keywords and Concepts MeSH Keywords Analgesics, Opioid Animals Drug Evaluation, Preclinical Hallucinogens Humans Opioid-Related Disorders Concepts Opioid use disorder Use disorder Preclinical studies Clinical studies Review of preclinical studies Conditioned place preference Opioid Self-Administration Effects of psychedelics Preclinical in vivo studies Opioid use disorder treatment Frequency of administration Place preference Potential therapeutic effects Self-Administration Withdrawal symptoms Preclinical findings Mechanism of action Safety profile Pain studies Psychedelics Methodological quality assessment Clinical evidence Cardiovascular risk Opioid Web of Science", + "Endocannabinoid Signaling and Food Addiction Bassir Nia A , D’souza D. Endocannabinoid Signaling and Food Addiction . 2024, 146-156. DOI: 10.1093/oso/9780190671051.003.0017 . Peer-Reviewed Original Research Concepts ECB system Food addiction Food reward processing Reward processing Abstract Cannabis Endogenous cannabinoids Increased food consumption Hedonic aspects High-fat foods Cannabis Addiction Stimulate appetite Stimulating effect Food intake ECB Anecdotal reports Clinical studies Psychopathology Appetite Cannabinoid Exocannabinoids Munchy Evidence Food consumption Hunger", + "Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals Korem N , Hillmer A , D’Souza D , Nia A , Levy I , Pietrzak R , Harpaz-Rotem I . Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals . JAMA Network Open 2024, 7: e2432387. PMID: 39250156 , PMCID: PMC11385051 , DOI: 10.1001/jamanetworkopen.2024.32387 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Adult Amygdala Emotions Female Humans Magnetic Resonance Imaging Male Pain Receptor, Cannabinoid, CB1 Stress Disorders, Post-Traumatic Young Adult Concepts Trauma-exposed individuals Posttraumatic stress disorder Cannabinoid 1 receptor Symptoms of veterans Emotional numbing Stress disorder Case-control study Pain response Pain Amygdala Veterans Disorders", + "Sex differences in the acute effects of oral THC: a randomized, placebo-controlled, crossover human laboratory study Mohammad Aghaei A, Urban Spillane L, Pittman B , Flynn L, De Aquino J , Bassir Nia A , Ranganathan M . Sex differences in the acute effects of oral THC: a randomized, placebo-controlled, crossover human laboratory study . Psychopharmacology 2024, 241: 2145-2155. PMID: 38832949 , DOI: 10.1007/s00213-024-06625-6 . Peer-Reviewed Original Research Citations Altmetric Concepts Rey Auditory Verbal Learning Test Cannabis use disorder Human laboratory studies Oral tetrahydrocannabinol Psychoactive effects Sex differences Auditory Verbal Learning Test Dissociative Symptoms Scale Psychotomimetic States Inventory Exposure to cannabis Verbal Learning Test Placebo-Controlled Increased cannabis use Investigate sex differences Clinician-Administered Verbal learning Psychotomimetic effects Cannabinoid effects Learning Test Cannabis use Tetrahydrocannabinol doses Effects of sex Use disorder Dose-related effects Individual vulnerability", + "Psychotherapeutic Interventions in Clinical Trials of Psychedelics for the Treatment of Alcohol Use Disorder Mohammad Aghaei A, Weleff J , Martins B, Ing K, Fontenele R, Barnett B, Anand A, Bassir Nia A . Psychotherapeutic Interventions in Clinical Trials of Psychedelics for the Treatment of Alcohol Use Disorder . Current Addiction Reports 2024, 11: 685-712. DOI: 10.1007/s40429-024-00574-y . Peer-Reviewed Original Research Citations Altmetric Concepts Treatment of AUD Use disorder Treatment of alcohol use disorders Modalities of psychotherapy Alcohol use disorder Psychedelic treatment Psychotherapeutic interventions Treat AUD Psychedelic compounds Psychedelic trials Psychotherapy Small numbers of participants Psychedelics Magnitude of improvement Methodological shortcomings AUD Numbers of participants Clinical trials Disorders Reviewed trials Short follow-up period Follow-up period Therapy methods Empirical evidence No significant difference", + "Dysregulation of the endogenous cannabinoid system following opioid exposure Mohammad Aghaei A, Saali A, Canas M, Weleff J , D'Souza D , Angarita G, Bassir Nia A . Dysregulation of the endogenous cannabinoid system following opioid exposure . Psychiatry Research 2023, 330: 115586. PMID: 37931479 , PMCID: PMC10842415 , DOI: 10.1016/j.psychres.2023.115586 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Analgesics, Opioid Brain Cannabinoids Endocannabinoids Humans Receptors, Cannabinoid Concepts Endocannabinoid system ECS components Brain regions Novel neurobiological targets Treatment of OUD Endogenous opioid system Opioid-related deaths Endogenous cannabinoid system Specific brain regions ECS dysregulation Opioid exposure OUD treatment Opioid system Cannabinoid system Neurobiological targets New medications Preclinical literature Cannabinoid receptors Endogenous ligand Therapeutic potential Study type Present potential targets Exposure protocol Opioids Preclinical research", + "Editorial: Psychedelics as treatments for substance use disorders: exploring therapeutic potential, risks, underlying mechanisms of action, and implementation challenges Barnett B, Nia A , Sackett N, Weleff J . Editorial: Psychedelics as treatments for substance use disorders: exploring therapeutic potential, risks, underlying mechanisms of action, and implementation challenges . Frontiers In Psychiatry 2023, 14: 1305478. PMID: 37928914 , PMCID: PMC10622752 , DOI: 10.3389/fpsyt.2023.1305478 . Peer-Reviewed Original Research Altmetric Concepts Substance use disorders Mechanism of action Psychedelics Therapeutic potential", + "155. Cannabis Use is Associated With Low Plasma Endocannabinoid Anandamide in Individuals With Psychosis Nia A , Gibson C , Spriggs S, Jankowskib S, DeFrancisco D, Swift A, Perkel C, Galynker I, Honrao C, Makriyannis A, Hurd Y. 155. Cannabis Use is Associated With Low Plasma Endocannabinoid Anandamide in Individuals With Psychosis . Biological Psychiatry 2023, 93: s156-s157. DOI: 10.1016/j.biopsych.2023.02.395 . Peer-Reviewed Original Research", + "Regular cannabis use is associated with history of childhood and lifetime trauma in a non-clinical community sample Bassir Nia A , Weleff J , Fogelman N , Nourbakhsh S, Sinha R . Regular cannabis use is associated with history of childhood and lifetime trauma in a non-clinical community sample . Journal Of Psychiatric Research 2023, 159: 159-164. PMID: 36736285 , PMCID: PMC10024801 , DOI: 10.1016/j.jpsychires.2023.01.036 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Cannabis Cocaine Cross-Sectional Studies Female Humans Substance-Related Disorders Surveys and Questionnaires Concepts Major life events Childhood trauma Life events Childhood Trauma Questionnaire Lifetime trauma Cannabis use Non-clinical community sample Chronic stress Neurobiology of stress Regular cannabis use Gender differences Regular use Self-report questionnaires Recent life events Potential gender differences Cross-sectional study Urine drug testing Life trauma Logistic regression analysis Adversity index Community sample Cannabis users Trauma Questionnaire High rate Substance use", + "Cannabis use is associated with low plasma endocannabinoid Anandamide in individuals with psychosis Nia A , Gibson C , Spriggs S, Jankowski S, DeFrancisco D, Swift A, Perkel C, Galynker I, Honrao C, Makriyannis A, Hurd Y. Cannabis use is associated with low plasma endocannabinoid Anandamide in individuals with psychosis . Journal Of Psychopharmacology 2023, 37: 484-489. PMID: 36633290 , DOI: 10.1177/02698811221148604 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Cannabinoid Receptor Agonists Cannabis Endocannabinoids Hallucinogens Humans Polyunsaturated Alkamides Psychotic Disorders Concepts Endocannabinoid system Cannabis use Plasma levels Healthy individuals Low plasma levels Plasma AEA levels Inpatient psychiatric unit Negative Syndrome Scale Race/ethnicity Urine toxicology AEA levels Psychotic presentations Endocannabinoid anandamide Clinical significance Self-report questionnaires Psychiatric unit Negative group Positive group Psychotic symptoms Main endocannabinoids Suppressive effect Syndrome Scale N-oleoylethanolamine Psychosis Further studies", + "Illness Phase as a Key Assessment and Intervention Window for Psychosis Kohler C, Wolf D, Abi-Dargham A, Anticevic A , Cho Y , Fonteneau C , Gil R , Girgis R, Gray D, Grinband J, Javitch J, Kantrowitz J, Krystal J , Lieberman J, Murray J , Ranganathan M , Santamauro N , Van Snellenberg J, Tamayo Z , Group T, D'Souza D , Srihari V , Gueorguieva R , Patel P, Forselius-Bielen K, Lu J, Butler A, Fram G , Afriyie-Agyemang Y, Selloni A, Cadavid L, Gomez-Luna S, Gupta A, Radhakrishnan R , Rashid A, Aker R, Abrahim P, Nia A , Surti T , Kegeles L, Carlson M, Goldberg T, Gangwisch J, Benedict E, Govil P, Brazis S, Mayer M, de la Garrigue N, Fallon N, Baumvoll T, Abeykoon S, Perlman G, Bobchin K, Elliott M, Schmidt L, Rush S, Port A, Heffernan Z, Laney N, Kantor J, Hohing T, Gur R, Gur R, Calkins M. Illness Phase as a Key Assessment and Intervention Window for Psychosis . Biological Psychiatry Global Open Science 2022, 3: 340-350. PMID: 37519466 , PMCID: PMC10382701 , DOI: 10.1016/j.bpsgos.2022.05.009 . Peer-Reviewed Original Research Citations Concepts Illness phase Potential critical windows Phase-specific biomarkers Dopaminergic abnormalities Functional outcome Specialty care Symptom assessment Illness stage Chronic illness Clinical assessment Illness trajectory Neurophysiological biomarkers Functional abnormalities Clinical care Early psychosis Memory dysfunction Psychotic disorders Treatment targets Allostatic adaptation Intervention window Clinical programs Brain development Critical window Dysfunction Illness", + "Sex Differences in the Acute Effects of Intravenous (IV) Delta-9 Tetrahydrocannabinol (THC) Nia A , Orejarena M, D’Souza D , Skosnik P , Pittman B , Ranganathan M . Sex Differences in the Acute Effects of Intravenous (IV) Delta-9 Tetrahydrocannabinol (THC) . Biological Psychiatry 2022, 91: s69. DOI: 10.1016/j.biopsych.2022.02.191 . Peer-Reviewed Original Research Altmetric", + "Sex differences in the acute effects of intravenous (IV) delta-9 tetrahydrocannabinol (THC) Bassir Nia A , Orejarena MJ, Flynn L, Luddy C , D’Souza D , Skosnik PD , Pittman B , Ranganathan M . Sex differences in the acute effects of intravenous (IV) delta-9 tetrahydrocannabinol (THC) . Psychopharmacology 2022, 239: 1621-1628. PMID: 35438304 , PMCID: PMC11215802 , DOI: 10.1007/s00213-022-06135-3 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Cannabinoid Receptor Agonists Cannabis Double-Blind Method Dronabinol Female Hallucinogens Humans Male Sex Characteristics Concepts Rey Auditory Verbal Learning Task Psychotomimetic States Inventory Cognitive effects Auditory Verbal Learning Task Subjective effects Delta-9-Tetrahydrocannabinol Sex differences Verbal learning task Dissociative Symptoms Scale Female participants Main psychoactive constituent Significant main effect Perceptual alterations Learning task States Inventory Psychoactive constituent Significant sex differences Main effect Male participants Visual analog scale Symptom Scale Test day Effects of cannabinoids Participants Psychotomimetic effects", + "Dopamine D1R Receptor Stimulation as a Mechanistic Pro-cognitive Target for Schizophrenia Abi-Dargham A, Javitch JA, Slifstein M, Anticevic A , Calkins ME, Cho YT , Fonteneau C , Gil R, Girgis R, Gur RE, Gur RC, Grinband J, Kantrowitz J, Kohler C, Krystal J , Murray J , Ranganathan M, Santamauro N , Van Snellenberg J, Tamayo Z , Wolf D, D’Souza D , Srihari V , Gueorguieva R , Patel P, Forselius-Bielen K, Lu J, Butler A, Fram G , Afriyie-Agyemang Y, Selloni A, Cadavid L, Gomez-Luna S, Gupta A, Radhakrishnan R , Rashid A, Aker R, Abrahim P, Nia A , Surti T , Kegeles L, Carlson M, Goldberg T, Gangwisch J, Benedict E, Govil P, Brazis S, Mayer M, de la Garrigue N, Fallon N, Baumvoll T, Abeykoon S, Perlman G, Bobchin K, Elliott M, Schmidt L, Rush S, Port A, Heffernan Z, Laney N, Kantor J, Hohing T, Gray D, Lieberman J. Dopamine D1R Receptor Stimulation as a Mechanistic Pro-cognitive Target for Schizophrenia . Schizophrenia Bulletin 2021, 48: 199-210. PMID: 34423843 , PMCID: PMC8781338 , DOI: 10.1093/schbul/sbab095 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Adult Cognitive Dysfunction Dopamine Agonists Drug Development Humans Receptors, Dopamine D1 Receptors, Dopamine D5 Schizophrenia Concepts Cortical dopamine neurotransmission Positive allosteric modulation Important therapeutic target PF-06412562 Dopaminergic receptors D1R stimulation DA levels Tolerable doses Level of stimulation Dopamine neurotransmission Receptor stimulation Therapeutic target Partial agonist Cognitive deficits Biased agonism Full agonism Target engagement Allosteric modulation New drugs Stimulation Poor bioavailability Schizophrenia Optimal stimulation Drugs Expression levels", + "Differential Effects of Childhood Vs. Adulthood Trauma in Cannabinoid Receptor Type 1 (CB1R) Availability in Post-Traumatic Stress Disorder (PTSD): A Review of Literature and Pilot Positron Emission Tomography (PET) Study Nia A , D'Souza C , Cosgrove K , Pietrzak R , Harpaz-Rotem I . Differential Effects of Childhood Vs. Adulthood Trauma in Cannabinoid Receptor Type 1 (CB1R) Availability in Post-Traumatic Stress Disorder (PTSD): A Review of Literature and Pilot Positron Emission Tomography (PET) Study . Biological Psychiatry 2021, 89: s328-s329. DOI: 10.1016/j.biopsych.2021.02.820 . Peer-Reviewed Original Research Citations Concepts Post-traumatic stress disorder Positron emission tomography study Emission tomography studies Review of literature Adulthood trauma Stress disorder Tomography study Differential effects Trauma", + "Multimodal Computational Modeling of Visual Object Recognition Deficits but Intact Repetition Priming in Schizophrenia Sehatpour P, Nia A , Adair D, Wang Z, DeBaun H, Silipo G, Martinez A, Javitt D. Multimodal Computational Modeling of Visual Object Recognition Deficits but Intact Repetition Priming in Schizophrenia . Frontiers In Psychiatry 2020, 11: 547189. PMID: 33329086 , PMCID: PMC7719812 , DOI: 10.3389/fpsyt.2020.547189 . Peer-Reviewed Original Research Citations Altmetric Concepts Functional magnetic resonance imaging Lateral occipital complex Prefrontal cortex Dorsal visual stream Perceptual closure Visual stream Hippocampal formation Network of cortical regions Object recognition deficits Line drawings Ventral visual stream Network-level interactions Adverse viewing conditions Repetition priming Recognition deficits Closure task Neural processes Occipital complex Cortical regions Schizophrenia Sensory information Magnetic resonance imaging Electrophysiological recordings Priming Cortex", + "Cannabinoid use in psychotic patients impacts inflammatory levels and their association with psychosis severity Gibson CL , Bassir Nia A , Spriggs SA, DeFrancisco D, Swift A, Perkel C, Zhong X, Mazumdar M, Fernandez N, Patel M, Kim-Schulze S, Hurd YL. Cannabinoid use in psychotic patients impacts inflammatory levels and their association with psychosis severity . Psychiatry Research 2020, 293: 113380. PMID: 32818918 , PMCID: PMC8292796 , DOI: 10.1016/j.psychres.2020.113380 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Adult Biomarkers Cannabinoids Female Humans Inflammation Mediators Male Marijuana Use Middle Aged Psychotic Disorders Severity of Illness Index Young Adult Concepts Interleukin-6 Psychosis severity Cannabinoid use Cannabis use IL-6 levels Common underlying pathology PANSS total score Chronic psychotic disorders Risk of psychosis Psychiatric emergency room Negative Syndrome Scale Psychotic symptom severity Inflammatory alterations Inflammatory markers Inflammatory disturbances Acute psychosis Inflammatory abnormalities Nata medication Underlying pathology Emergency room Inflammatory levels PANSS scores Psychiatric unit Unadjusted models Psychotic disorders", + "Differential Effects of Childhood Vs. Adulthood Trauma in Cannabinoid Receptor Type 1 (CB1R) Availability in Post-Traumatic Stress Disorder (PTSD): A Review of Literature and Pilot Positron Emission Tomography (PET) Study Nia A , D'Souza C , Cosgrove K , Pietrzak R , Harpaz-Rotem I . Differential Effects of Childhood Vs. Adulthood Trauma in Cannabinoid Receptor Type 1 (CB1R) Availability in Post-Traumatic Stress Disorder (PTSD): A Review of Literature and Pilot Positron Emission Tomography (PET) Study . Biological Psychiatry 2020, 87: s381. DOI: 10.1016/j.biopsych.2020.02.976 . Peer-Reviewed Original Research Concepts Post-traumatic stress disorder Positron emission tomography study Emission tomography studies Review of literature Adulthood trauma Stress disorder Tomography study Differential effects Trauma", + "The Relevance of Sex in the Association of Synthetic Cannabinoid Use With Psychosis and Agitation in an Inpatient Population. Bassir Nia A , Mann CL, Spriggs S, DeFrancisco DR, Carbonaro S, Parvez L, Galynker II, Perkel CA, Hurd YL. The Relevance of Sex in the Association of Synthetic Cannabinoid Use With Psychosis and Agitation in an Inpatient Population. The Journal Of Clinical Psychiatry 2019, 80 PMID: 31265768 , PMCID: PMC8445109 , DOI: 10.4088/jcp.18m12539 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Adult Cannabinoids Dronabinol Female Humans Inpatients Male Psychomotor Agitation Psychoses, Substance-Induced Psychotropic Drugs Risk Factors Sex Factors Substance Abuse Detection United States Concepts Toxicology screen Relevance of sex Synthetic cannabinoid use SC use Positive urine toxicology screen Cannabinoid use Urine toxicology screen Retrospective chart review Positive toxicology screen Effects of cannabinoids SC users Rates of psychosis Chart review Pharmacologic treatment Clinical symptoms Inpatient population Inpatient setting Psychotic presentations Use of substances Study group High risk Psychiatric unit Current evidence Control group Psychosis", + "Endocannabinoid System Alterations in Posttraumatic Stress Disorder: A Review of Developmental and Accumulative Effects of Trauma Nia A , Bender R, Harpaz-Rotem I . Endocannabinoid System Alterations in Posttraumatic Stress Disorder: A Review of Developmental and Accumulative Effects of Trauma . Chronic Stress 2019, 3: 2470547019864096. PMID: 31660473 , PMCID: PMC6816276 , DOI: 10.1177/2470547019864096 . Peer-Reviewed Original Research Citations Altmetric Concepts Endocannabinoid system alterations Endocannabinoid system System alterations Endocannabinoid ligands Prolonged stress Posttraumatic stress disorder Important sex differences Clinical studies Psychiatric symptoms Cannabinoid receptors Human studies Chronic stress Stress disorder Trauma Decreased levels Developmental age Sex differences Current literature Receptors Alterations Accumulative effect Review Symptoms Levels", + "", + "Calendar", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Aksoy Lab", + "lab_url": "https://medicine.yale.edu/lab/aksoy/", + "research_bio": "INFORMATION FOR Our lab studies multiple aspects of tsetse flies, the vectors of African trypanosomes. Trypanosomes are the causative agents of the devastating Sleeping Sickness disease in Sub-Saharan Africa. The lab’s work spans a range of projects including tsetse immunity, reproduction and symbiosis, tsetse-symbiont and trypanosome interactions, tsetse genomics and population genetics, and trypanosome developmental processes in tsetse. The ultimate goal of our work is to improve current control methods and/or develop novel strategies to reduce or eliminate the transmission of Sleeping Sickness in Sub-Saharan Africa. Copy Link Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/aksoy/publications", + "publications": [ + "Yale School of Public Health /", + "News", + "People", + "Research and Training Tsetse Genomics and Bioinformatics Tsetse Reproductive Biology Tsetse Population Genetics-Genomics Trypanosome Biology in Tsetse Biology of Tsetse Symbionts Paratransgenesis GID Training program NAIAD RO1 NIH ICIDR Project", + "Tsetse Genomics and Bioinformatics", + "Tsetse Reproductive Biology", + "Tsetse Population Genetics-Genomics", + "Trypanosome Biology in Tsetse", + "Biology of Tsetse Symbionts", + "Paratransgenesis", + "GID Training program", + "NAIAD RO1", + "NIH ICIDR Project", + "Publications Genomics, Transcriptomics and Proteomics Vector Parasite/Symbiont Interactions Reproduction Salivary Gland Biology Population Genetics and Ecology", + "Genomics, Transcriptomics and Proteomics", + "Vector Parasite/Symbiont Interactions", + "Reproduction", + "Salivary Gland Biology", + "Population Genetics and Ecology", + "Prospective Students", + "Alumni", + "Donors", + "Employers", + "Academic Calendar", + "myYSPH Members", + "Support YSPH", + "Home", + "Publications", + "Genomics, Transcriptomics and Proteomics", + "Vector Parasite/Symbiont Interactions", + "Reproduction", + "Salivary Gland Biology", + "Population Genetics and Ecology", + "", + "", + "", + "", + "", + "", + "Genomics, Transcriptomics and Proteomics", + "Population Genetics and Ecology Publications", + "Reproduction Publications", + "Salivary Biology Publications", + "Vector Parasite/Symbiont Interactions Publications", + "Calendar", + "PO Box 208034 New Haven, CT 06520-8034", + "Contact Us", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Alagpulinsa Laboratory", + "lab_url": "https://medicine.yale.edu/lab/alagpulinsa/", + "research_bio": "INFORMATION FOR The AlagsLab is an interdisciplinary research group dedicated to uncovering how the hematopoietic system connects human complex traits and diseases through shared genetic and molecular mechanisms. Our work centers on autoimmune diseases—particularly type 1 diabetes—and their relationship with cardiovascular disease and neurocognitive outcomes. We use these conditions as entry points to understand how genetic alterations in hematopoietic function shape multi-trait risk, resilience, and comorbidity. We integrate molecular and statistical genetics, single-cell and multi-omics, immunobiology, pharmacology, bioengineering, and computational biology to dissect how hematopoietic mechanisms mediate disease intersection or antagonism. Our overarching goal is to translate genetic and regulatory discoveries into actionable biomarkers and therapeutic targets that advance precision medicine and inspire new avenues for drug discovery. Equally central to our mission is training the next generation of scientists. We foster a rigorous, collaborative, and inclusive environment where curiosity and cross-disciplinary thinking thrive—turning fundamental insights into preclinical and translational advances that lay the groundwork for future therapies. We come to the lab each morning not for routine, but for renewal — driven by curiosity, discipline, and empathy, we serve humanity through science, uncovering the principles that govern human biology and transforming them into knowledge that heals. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/alagpulinsa/publications/", + "publications": [ + "Yale School of Medicine /", + "Comparative Medicine /", + "About the AlagsLab", + "News", + "Research", + "Opportunities", + "Publications", + "Diversity", + "Lab Members", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "About the AlagsLab", + "Research", + "Publications", + "Lab Members", + "News", + "Opportunities", + "Diversity", + "", + "", + "", + "", + "", + "", + "Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits Saarah P, Syeda ZA, Xu Z, Dong Y, Jiang A, Shanguhyia M, Roy S, Zhu B, Zhang L, Dewan AT, Asgari S, Alagpulinsa DA*. Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits. medRxiv. 2025. Doi: https://doi.org/10.1101/2025.09.14.25335719 Peer-Reviewed Original Research", + "Genetic relations between type 1 diabetes, coronary artery disease and leukocyte counts. Adebekun J, Nadig A, Saarah P, Asgari S, Kachuri L, Alagpulinsa DA. Genetic relations between type 1 diabetes, coronary artery disease and leukocyte counts. Diabetologia 2024 PMID: 39141130 , DOI: 10.1007/s00125-024-06247-9. Peer-Reviewed Original Research", + "Association of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV Schnittman S, Talathi R, Wilks M , Hedgire S, Lu M, Fourman L, Alagpulinsa D, Stockman S, White K, Wallis Z, Autissier P, Stanley T, Lee H, Honigberg M, El-Fakhri G , Williams K, Zanni M, Grinspoon S, Toribio M. Association of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV . AIDS 2024, 38: 1940-1946. PMID: 38905489 , PMCID: PMC11701974 , DOI: 10.1097/qad.0000000000003967 . Peer-Reviewed Original Research Altmetric Concepts Arterial infiltration Cardiovascular disease Increased risk of cardiovascular disease Human immunodeficiency virus T cell subtypes T lymphocyte subpopulations Risk of cardiovascular disease Systemic monocyte activation Cardiovascular disease risk Immunodeficiency virus Monocyte activation HIV status Increased risk Relevant to atherogenesis HIV Infiltration General population PWH Evidence of interaction Subtypes Disease Subpopulations Atherogenesis", + "Genetic relations between leukocyte counts, type 1 diabetes, and coronary artery disease Adebekun J, Nadig A, Saarah P, Asgari S, Kachuri L, and Alagpulinsa DA*. Genetic relations between leukocyte counts, type 1 diabetes, and coronary artery disease. medRxiv, 2024: p. 2024.04.01.24305155. Peer-Reviewed Original Research", + "Short-term function and immune-protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non-human primates without systemic immune suppression: A pilot study. Sremac M, Luo H, Deng H, Parr MFE, Hutcheson J, Verde PS, Alagpulinsa DA, Kitzmann JM, Papas KK, Brauns T, Markmann JF, Lei J, Poznansky MC. Short-term function and immune-protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non-human primates without systemic immune suppression: A pilot study. Xenotransplantation 2023, e12826. PMID: 37712342 , DOI: 10.1111/xen.12826. Peer-Reviewed Original Research", + "Plasma osteopontin relates to myocardial fibrosis and steatosis and to immune activation among women with HIV. Robinson JA, Toribio M, Quinaglia T, Awadalla M, Talathi R, Durbin CG, Alhallak I, Alagpulinsa DA, Fourman LT, Suero-Abreu GA, Nelson MD, Stanley TL, Longenecker CT, Szczepaniak LS, Jerosch-Herold M, Neilan TG, Zanni MV, Burdo TH. Plasma osteopontin relates to myocardial fibrosis and steatosis and to immune activation among women with HIV. AIDS 2023, 37: 305-310. PMID: 36541642 , DOI: 10.1097/QAD.0000000000003417. Peer-Reviewed Original Research", + "Cardiac strain is lower among women with HIV in relation to monocyte activation. Toribio M, Awadalla M, Drobni ZD, Quinaglia T, Wang M, Durbin CG, Alagpulinsa DA, Fourman LT, Suero-Abreu GA, Nelson MD, Stanley TL, Longenecker CT, Burdo TH, Neilan TG, Zanni MV. Cardiac strain is lower among women with HIV in relation to monocyte activation. PLoS One 2022, 17: e0279913. PMID: 36584183 , DOI: 10.1371/journal.pone.0279913. Peer-Reviewed Original Research", + "Advances in understanding the molecular basis of clonal hematopoiesis. Alagpulinsa DA, Toribio MP, Alhallak I, Shmookler Reis RJ. Advances in understanding the molecular basis of clonal hematopoiesis. Trends Mol Med 2022, 28: 360-377. PMID: 35341686 , DOI: 10.1016/j.molmed.2022.03.002. Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements", + "Metabolomic and transcriptomic analyses of the anti-rheumatoid arthritis potential of xylopic acid in a bioinspired lipoprotein nanoformulation. Alolga RN, Opoku-Damoah Y, Alagpulinsa DA, Huang FQ, Ma G, Chavez Leon MASC, Kudzai C, Yin X, Ding Y. Metabolomic and transcriptomic analyses of the anti-rheumatoid arthritis potential of xylopic acid in a bioinspired lipoprotein nanoformulation. Biomaterials 2021, 268: 120482. PMID: 33307367 , DOI: 10.1016/j.biomaterials.2020.120482. Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements", + "Genomic Instability in Multiple Myeloma. Alagpulinsa DA, Szalat RE, Poznansky MC, Shmookler Reis RJ. Genomic Instability in Multiple Myeloma. Trends Cancer 2020, 6: 858-873. PMID: 32487486 , DOI: 10.1016/j.trecan.2020.05.006. Peer-Reviewed Original Research", + "Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma. Alagpulinsa D, Kumar S, Talluri S, Nanjappa P, Buon L, Chakraborty C, Samur M, Szalat R, Shammas M, Munshi N. Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma. Blood Advances 2019, 3: 3968-3972. PMID: 31805191 , PMCID: PMC6963244 , DOI: 10.1182/bloodadvances.2019000181 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Homologous Recombination Humans Multiple Myeloma Ubiquitin Ubiquitin-Conjugating Enzymes Concepts Multiple myeloma cells Myeloma cells UBE2T Potential therapeutic target Multiple myeloma Therapeutic target Cells Myeloma Chemosensitivity Homologous recombination activity", + "Alginate-microencapsulation of human stem cell-derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression. Alagpulinsa DA, Cao JJL, Driscoll RK, Sîrbulescu RF, Penson MFE, Sremac M, Engquist EN, Brauns TA, Markmann JF, Melton DA, Poznansky MC. Alginate-microencapsulation of human stem cell-derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression. Am J Transplant 2019, 19: 1930-1940. PMID: 30748094 , DOI: 10.1111/ajt.15308. Peer-Reviewed Original Research", + "Harnessing CXCL12 signaling to protect and preserve functional β-cell mass and for cell replacement in type 1 diabetes. Alagpulinsa DA, Cao JJL, Sobell D, Poznansky MC. Harnessing CXCL12 signaling to protect and preserve functional β-cell mass and for cell replacement in type 1 diabetes. Pharmacol Ther 2019, 193: 63-74. PMID: 30149101 , DOI: 10.1016/j.pharmthera.2018.08.011. Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements", + "A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition. Alagpulinsa DA, Ayyadevara S, Yaccoby S, Shmookler Reis RJ. A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition. Mol Cancer Ther 2016, 15: 241-50. PMID: 26719576 , DOI: 10.1158/1535-7163.MCT-15-0660. Peer-Reviewed Original Research", + "A peptide nucleic acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan treatment. Alagpulinsa DA, Yaccoby S, Ayyadevara S, Shmookler Reis RJ. A peptide nucleic acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan treatment. Cancer Biol Ther 2015, 16: 976-86. PMID: 25996477 , DOI: 10.1080/15384047.2015.1040951. Peer-Reviewed Original Research", + "A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin. Alagpulinsa DA, Ayyadevara S, Shmookler Reis RJ. A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin. Front Oncol 2014, 4: 289. PMID: 25401086 , DOI: 10.3389/fonc.2014.00289. Peer-Reviewed Original Research", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Ameen Lab", + "lab_url": "https://medicine.yale.edu/lab/ameen/", + "research_bio": "INFORMATION FOR The central focus of our laboratory is aimed at understanding the mechanisms regulating traffic of ion transporters into and out of the intestinal brush border membrane and how dysregulation of traffic leads to intestinal diseases (either constipation or diarrhea). While our main focus is the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), we investigate all ion transporters in the enterocyte plasma membrane. To this end, we were the first to demonstrate a physiologic role for regulated traffic of CFTR in the pathogenesis of infectious ( Cholera and E.Coli) secretory diarrhea, and extended those studies to other ion transporters. We identified a unique enterocyte (CFTR High Expresser cell, CHE) expressing unusually high levels of CFTR in the human and rodent intestine that possess a strong secretory phenotype on the absorptive villus epithelium of the proximal small intestine. CHE cells likely play an important role in diarrheal diseases and Cystic Fibrosis, but much more needs to be done to understand the role of these cells. We were also the first to propose an apical trafficking defect in the inherited childhood diarrheal disease, Microvillus Inclusion Disease (MVID). Ongoing work in our lab seeks to understand the underlying pathogenesis of the diarrhea in MVID that leads to early death in newborns. We work in collaboration with colleagues in medical centers in the Netherlands, Yale and other institutions, and partner with pharmaceutical companies to help elucidate mechanisms of action of drugs that signal CFTR. Our studies are supported by the NIH and Industry. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/ameen/publications/", + "publications": [ + "Yale School of Medicine /", + "Cellular & Molecular Physiology /", + "About Us", + "Projects", + "Lab Members", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "About Us", + "Projects", + "Lab Members", + "Publications", + "", + "", + "", + "", + "", + "", + "CFTR High Expresser BEST4(+) cells are pH-sensing neuropod cells: new implications for intestinal physiology and cystic fibrosis disease. Dos Reis DC, Jin J, Santos A, Dastoor P, Muiler C, Zagoren E, Donnelley M, Parsons D, Cmielewski P, Reyne N, McCarron A, Smith Z, Sumigray K, Ameen NA. Am J Physiol Cell Physiol. 2025 Nov 1; 2025 Sep 26. PMID: 41005986.", + "Building capacity for HIV and implementation science among students in the United States: the stimulating training and access to HIV research experiences (STAR) program. Nwaozuru U, Tucker JD, Thurston IB, Airhihenbuwa CO, BeLue R, Tang W, Obiezu-Umeh C, Anikamadu O, Ameen K, Herrara C, Engelhart A, Patrick T, Onyeama U, Oladele D, Takenaka BP, Olusanya OA, Ojo T, Iwelunmor J. Front Public Health. 2025; 2025 Oct 14. PMID: 41164842.", + "Clinical outcomes of transcatheter aortic valve replacement in patients with radiation-induced aortic stenosis: a systematic review and meta-analysis. Ameen D, Thakker N, Contreras R, Hashemi SM, Nasrollahizadeh A, Saberian P, Kuriyakose D, Amini-Salehi E, Keetha NR, Nayak SS. Front Cardiovasc Med. 2025; 2025 Aug 12. PMID: 40873615.", + "The impact of weight loss interventions on thyroid function: a systematic review and meta-analysis. Nayak SS, Hashemi SM, Patel M, Shafi N, Biswas P, Javankiani S, Jaladi P, Patil SB, Rashid R, Amini-Salehi E, Ameen D, Viresh Janani K, Jonnalagadda AK, Agyeman KB. Ann Med Surg (Lond). 2025 Jul; 2025 May 26. PMID: 40852024.", + "Evidence of secondary Notch signaling within the rat small intestine. Zagoren E, Dias N, Santos AK, Smith ZD, Ameen NA, Sumigray K. Development. 2025 Jun 1; 2025 Jun 3. PMID: 40371707.", + "Clinical outcomes of transcatheter edge-to-edge repair in patients with acute mitral regurgitation complicated by cardiogenic shock: a systematic review and meta-analysis. Ahmed A, Contreras R, Gurram A, Saberian P, Kaddoura R, Boyea K, Issaka Y, Hashemi SM, Ameen D, Nobakht S, Amini-Salehi E, Nayak SS. BMC Cardiovasc Disord. 2025 May 19; 2025 May 19. PMID: 40389818.", + "Research trends in CAR-T cell therapy: A comprehensive bibliometric analysis highlighting cardiovascular toxicity and clinical implications. Ameen D, Amini-Salehi E, Nayak SS, Ahmed A, Pudimat A, Nasrollahizadeh A, Hosseini K, Hosseini Jebelli SF, Alizadeh Asl A, Nguyen AL. Medicine (Baltimore). 2025 May 16. PMID: 40388795.", + "The predictive value of endocan as a novel biomarker: an umbrella study on meta-analyses. Nayak SS, Ameen D, Nobakht S, Nayak R, Prabhu SV, Keivanlou MH, Hassanipour S, Amini-Salehi E, Thakker N. Syst Rev. 2025 May 1; 2025 May 1. PMID: 40312748.", + "Bibliometric analysis of artificial intelligence applications in cardiovascular imaging: trends, impact, and emerging research areas. Alotaibi A, Contreras R, Thakker N, Mahapatro A, Adla Jala SR, Mohanty E, Devulapally P, Mirchandani M, Marsool Marsool MD, Jain SM, Joukar F, Alizadehasl A, Hosseini Jebelli SF, Amini-Salehi E, Ameen D. Ann Med Surg (Lond). 2025 Apr; 2025 Feb 28. PMID: 40212204.", + "Artificial intelligence in cardiovascular procedures: a bibliometric and visual analysis study. Gadhachanda KR, Marsool Marsool MD, Bozorgi A, Ameen D, Nayak SS, Nasrollahizadeh A, Alotaibi A, Farzaei A, Keivanlou MH, Hassanipour S, Amini-Salehi E, Jonnalagadda AK. Ann Med Surg (Lond). 2025 Apr; 2025 Feb 28. PMID: 40212154.", + "Clinical Outcomes and Prognostic Implications of TAVR in Patients With Active Cancer: A Meta-Analysis. Saberian P, Contreras R, Gurram A, Nasrollahizadeh A, Keetha NR, Nguyen AL, Nayak SS, Keivanlou MH, Hashemi M, Amini-Salehi E, Ameen D. Clin Cardiol. 2025 Mar. PMID: 40123522.", + "Acute coronary syndrome in patients with autosomal dominant polycystic kidney disease: a systematic review and meta-analysis. Ahmed A, Nayak S, Hoteit M, Ameen D, Bauer D, Elshenawy S, Stolear A, Kaddoura R, Buller G. Intern Med J. 2025 Mar; 2025 Mar 8. PMID: 40055956.", + "CFTR High Expresser BEST4+ cells are pH-sensing neuropod cells: new implications for intestinal physiology and Cystic Fibrosis disease. Dos Reis DC, Jin J, Santos A, Muiler C, Zagoren E, Donnelley M, Parsons D, Cmielewski P, Reyne N, McCarron A, Smith Z, Sumigray K, Ameen NA. bioRxiv. 2025 Jan 27; 2025 Jan 27. PMID: 39974899.", + "Measurement of breast artery calcification using an artificial intelligence detection model and its association with major adverse cardiovascular events. Rose SJ, Hartnett J, Estep ZJ, Ameen D, Karki S, Schuster E, Newman RB, Hsi DH. PLOS Digit Health. 2024 Dec; 2024 Dec 23. PMID: 39715147.", + "Cardiovascular and all-cause mortality outcomes of adrenalectomy versus medical treatment in primary aldosteronism: an umbrella review. Nayak SS, Amini-Salehi E, Joukar F, Biswas P, Nobakht S, Letafatkar N, Porteghali P, Mohammadi-Vajari E, Mansour-Ghanaei F, Javid M, Mirdamadi A, Ameen D, Motamed B, Hassanipour S, Keivanlou MH. Int J Surg. 2024 Nov 1; 2024 Nov 1. PMID: 39248318.", + "Localization and function of humanized F508del-CFTR in mouse intestine following activation of serum glucocorticoid kinase 1 and Trikafta. Dastoor P, Muiler C, Garrison A, Egan M, Carlos Dos Reis D, Santos A, Ameen NA. Eur J Pharmacol. 2024 Sep 5; 2024 Jun 24. PMID: 38925289.", + "Diagnostic and prognostic value of triglyceride glucose index: a comprehensive evaluation of meta-analysis. Nayak SS, Kuriyakose D, Polisetty LD, Patil AA, Ameen D, Bonu R, Shetty SP, Biswas P, Ulrich MT, Letafatkar N, Habibi A, Keivanlou MH, Nobakht S, Alotaibi A, Hassanipour S, Amini-Salehi E. Cardiovasc Diabetol. 2024 Aug 23; 2024 Aug 23. PMID: 39180024.", + "Unraveling the Enigma of Gossypiboma: A Series of 14 Cases Highlighting the Prevalence, Root Causes, and Outcomes in Resource-Limited Settings. Al-Wageeh S, AlShoaibi IA, Abdo B, Ahmed F, Ghabisha SA, Badheeb M, Ameen M. Cureus. 2024 Jul; 2024 Jul 4. PMID: 39100026.", + "Combination of Measurements of the Top Quark Mass from Data Collected by the ATLAS and CMS Experiments at sqrt[s]=7 and 8 TeV. Hayrapetyan A, Tumasyan A, Adam W, Andrejkovic JW, Bergauer T, Chatterjee S, Damanakis K, Dragicevic M, Hussain PS, Jeitler M, Krammer N, Li A, Liko D, Mikulec I, Schieck J, Schöfbeck R, Schwarz D, Sonawane M, Templ S, Waltenberger W, Wulz CE, Darwish MR, Janssen T, Van Mechelen P, Bols ES, D'Hondt J, Dansana S, De Moor A, Delcourt M, El Faham H, Lowette S, Makarenko I, Müller D, Sahasransu AR, Tavernier S, Tytgat M, Van Putte S, Vannerom D, Clerbaux B, De Lentdecker G, Favart L, Hohov D, Jaramillo J, Khalilzadeh A, Lee K, Mahdavikhorrami M, Malara A, Paredes S, Pétré L, Postiau N, Thomas L, Vanden Bemden M, Vander Velde C, Vanlaer P, De Coen M, Dobur D, Hong Y, Knolle J, Lambrecht L, Mestdach G, Rendón C, Samalan A, Skovpen K, Van Den Bossche N, van der Linden J, Wezenbeek L, Benecke A, Bruno G, Caputo C, Delaere C, Donertas IS, Giammanco A, Jaffel K, Jain S, Lemaitre V, Lidrych J, Mastrapasqua P, Mondal K, Tran TT, Wertz S, Alves GA, Coelho E, Hensel C, Menezes De Oliveira T, Moraes A, Rebello Teles P, Soeiro M, Aldá Júnior WL, Alves Gallo Pereira M, Barroso Ferreira Filho M, Brandao Malbouisson H, Carvalho W, Chinellato J, Da Costa EM, Da Silveira GG, De Jesus Damiao D, Fonseca De Souza S, Gomes De Souza R, Martins J, Mora Herrera C, Mota Amarilo K, Mundim L, Nogima H, Santoro A, Sznajder A, Thiel M, Vilela Pereira A, Bernardes CA, Calligaris L, Tomei TRFP, Gregores EM, Mercadante PG, Novaes SF, Orzari B, Padula SS, Aleksandrov A, Antchev G, Hadjiiska R, Iaydjiev P, Misheva M, Shopova M, Sultanov G, Dimitrov A, Litov L, Pavlov B, Petkov P, Petrov A, Shumka E, Keshri S, Thakur S, Cheng T, Guo Q, Javaid T, Yuan L, Hu Z, Liu J, Yi K, Chen GM, Chen HS, Chen M, Iemmi F, Jiang CH, Kapoor A, Liao H, Liu ZA, Sharma R, Song JN, Tao J, Wang C, Wang J, Wang Z, Zhang H, Agapitos A, Ban Y, Levin A, Li C, Li Q, Mao Y, Qian SJ, Sun X, Wang D, Yang H, Zhang L, Zhou C, You Z, Lu N, Bauer G, Gao X, Leggat D, Okawa H, Zhang Y, Lin Z, Lu C, Xiao M, Avila C, Barbosa Trujillo DA, Cabrera A, Florez C, Fraga J, Reyes Vega JA, Mejia Guisao J, Ramirez F, Rodriguez M, Ruiz Alvarez JD, Giljanovic D, Godinovic N, Lelas D, Sculac A, Kovac M, Sculac T, Bargassa P, Brigljevic V, Chitroda BK, Ferencek D, Mishra S, Starodumov A, Susa T, Attikis A, Christoforou K, Konstantinou S, Mousa J, Nicolaou C, Ptochos F, Razis PA, Rykaczewski H, Saka H, Stepennov A, Finger M, Finger M, Kveton A, Ayala E, Carrera Jarrin E, Abdalla H, Assran Y, Mahmoud MA, Mohammed Y, Dewanjee RK, Ehataht K, Kadastik M, Lange T, Nandan S, Nielsen C, Pata J, Raidal M, Tani L, Veelken C, Kirschenmann H, Osterberg K, Voutilainen M, Bharthuar S, Brücken E, Garcia F, Havukainen J, Kallonen KTS, Kinnunen R, Lampén T, Lassila-Perini K, Lehti S, Lindén T, Lotti M, Martikainen L, Myllymäki M, Rantanen MM, Siikonen H, Tuominen E, Tuominiemi J, Luukka P, Petrow H, Tuuva T, Besancon M, Couderc F, Dejardin M, Denegri D, Faure JL, Ferri F, Ganjour S, Gras P, Hamel de Monchenault G, Lohezic V, Malcles J, Rander J, Rosowsky A, Sahin MÖ, Savoy-Navarro A, Simkina P, Titov M, Tornago M, Baldenegro Barrera C, Beaudette F, Buchot Perraguin A, Busson P, Cappati A, Charlot C, Damas F, Davignon O, De Wit A, Falmagne G, Fontana Santos Alves BA, Ghosh S, Gilbert A, Granier de Cassagnac R, Hakimi A, Harikrishnan B, Kalipoliti L, Liu G, Motta J, Nguyen M, Ochando C, Portales L, Salerno R, Sauvan JB, Sirois Y, Tarabini A, Vernazza E, Zabi A, Zghiche A, Agram JL, Andrea J, Apparu D, Bloch D, Brom JM, Chabert EC, Collard C, Falke S, Goerlach U, Grimault C, Haeberle R, Le Bihan AC, Meena M, Saha G, Sessini MA, Van Hove P, Beauceron S, Blancon B, Boudoul G, Chanon N, Choi J, Contardo D, Depasse P, Dozen C, El Mamouni H, Fay J, Gascon S, Gouzevitch M, Greenberg C, Grenier G, Ille B, Laktineh IB, Lethuillier M, Mirabito L, Perries S, Purohit A, Vander Donckt M, Verdier P, Xiao J, Lomidze D, Lomidze I, Tsamalaidze Z, Botta V, Feld L, Klein K, Lipinski M, Meuser D, Pauls A, Röwert N, Teroerde M, Diekmann S, Dodonova A, Eich N, Eliseev D, Engelke F, Erdmann M, Fackeldey P, Fischer B, Hebbeker T, Hoepfner K, Ivone F, Jung A, Lee MY, Mastrolorenzo L, Mausolf F, Merschmeyer M, Meyer A, Mukherjee S, Noll D, Novak A, Nowotny F, Pozdnyakov A, Rath Y, Redjeb W, Rehm F, Reithler H, Sarkar U, Sarkisovi V, Schmidt A, Sharma A, Spah JL, Stein A, Torres Da Silva De Araujo F, Vigilante L, Wiedenbeck S, Zaleski S, Dziwok C, Flügge G, Haj Ahmad W, Kress T, Nowack A, Pooth O, Stahl A, Ziemons T, Zotz A, Aarup Petersen H, Aldaya Martin M, Alimena J, Amoroso S, An Y, Baxter S, Bayatmakou M, Becerril Gonzalez H, Behnke O, Belvedere A, Bhattacharya S, Blekman F, Borras K, Brunner D, Campbell A, Cardini A, Cheng C, Colombina F, Consuegra Rodríguez S, Correia Silva G, De Silva M, Eckerlin G, Eckstein D, Estevez Banos LI, Filatov O, Gallo E, Geiser A, Giraldi A, Greau G, Guglielmi V, Guthoff M, Hinzmann A, Jafari A, Jeppe L, Jomhari NZ, Kaech B, Kasemann M, Kaveh H, Kleinwort C, Kogler R, Komm M, Krücker D, Lange W, Leyva Pernia D, Lipka K, Lohmann W, Mankel R, Melzer-Pellmann IA, Mendizabal Morentin M, Metwally J, Meyer AB, Milella G, Mussgiller A, Nair LP, Nürnberg A, Otarid Y, Park J, Pérez Adán D, Ranken E, Raspereza A, Ribeiro Lopes B, Rübenach J, Saggio A, Scham M, Schnake S, Schütze P, Schwanenberger C, Selivanova D, Shchedrolosiev M, Sosa Ricardo RE, Stafford D, Vazzoler F, Ventura Barroso A, Walsh R, Wang Q, Wen Y, Wichmann K, Wiens L, Wissing C, Yang Y, Zimermmane Castro Santos A, Albrecht A, Albrecht S, Antonello M, Bein S, Benato L, Bonanomi M, Connor P, Eich M, El Morabit K, Fischer Y, Fröhlich A, Garbers C, Garutti E, Grohsjean A, Hajheidari M, Haller J, Jabusch HR, Kasieczka G, Keicher P, Klanner R, Korcari W, Kramer T, Kutzner V, Labe F, Lange J, Lobanov A, Matthies C, Mehta A, Moureaux L, Mrowietz M, Nigamova A, Nissan Y, Paasch A, Pena Rodriguez KJ, Quadfasel T, Raciti B, Rieger M, Savoiu D, Schindler J, Schleper P, Schröder M, Schwandt J, Sommerhalder M, Stadie H, Steinbrück G, Tews A, Wolf M, Brommer S, Burkart M, Butz E, Chwalek T, Dierlamm A, Droll A, Faltermann N, Giffels M, Gottmann A, Hartmann F, Hofsaess R, Horzela M, Husemann U, Kieseler J, Klute M, Koppenhöfer R, Lawhorn JM, Link M, Lintuluoto A, Maier S, Mitra S, Mormile M, Müller T, Neukum M, Oh M, Presilla M, Quast G, Rabbertz K, Regnery B, Shadskiy N, Shvetsov I, Simonis HJ, Toms M, Trevisani N, Ulrich R, Von Cube RF, Wassmer M, Wieland S, Wittig F, Wolf R, Wunsch S, Zuo X, Anagnostou G, Daskalakis G, Kyriakis A, Papadopoulos A, Stakia A, Kontaxakis P, Melachroinos G, Panagiotou A, Papavergou I, Paraskevas I, Saoulidou N, Theofilatos K, Tziaferi E, Vellidis K, Zisopoulos I, Bakas G, Chatzistavrou T, Karapostoli G, Kousouris K, Papakrivopoulos I, Siamarkou E, Tsipolitis G, Zacharopoulou A, Adamidis K, Bestintzanos I, Evangelou I, Foudas C, Gianneios P, Kamtsikis C, Katsoulis P, Kokkas P, Kosmoglou Kioseoglou PG, Manthos N, Papadopoulos I, Strologas J, Bartók M, Hajdu C, Horvath D, Sikler F, Veszpremi V, Csanád M, Farkas K, Gadallah MMA, Kadlecsik Á, Major P, Mandal K, Pásztor G, Rádl AJ, Veres GI, Raics P, Ujvari B, Zilizi G, Bencze G, Czellar S, Karancsi J, Molnar J, Szillasi Z, Csorgo T, Nemes F, Novak T, Babbar J, Bansal S, Beri SB, Bhatnagar V, Chaudhary G, Chauhan S, Dhingra N, Kaur A, Kaur A, Kaur H, Kaur M, Kumar S, Sandeep K, Sheokand T, Singh JB, Singla A, Ahmed A, Bhardwaj A, Chhetri A, Choudhary BC, Kumar A, Kumar A, Naimuddin M, Ranjan K, Saumya S, Baradia S, Barman S, Bhattacharya S, Dutta S, Dutta S, Palit P, Sarkar S, Ameen MM, Behera PK, Behera SC, Chatterjee S, Jana P, Kalbhor P, Komaragiri JR, Kumar D, Panwar L, Pujahari PR, Saha NR, Sharma A, Sikdar AK, Verma S, Dugad S, Kumar M, Mohanty GB, Suryadevara P, Bala A, Banerjee S, Chatterjee RM, Guchait M, Jain S, Karmakar S, Kumar S, Majumder G, Mazumdar K, Parolia S, Thachayath A, Bahinipati S, Das AK, Kar C, Maity D, Mal P, Mishra T, Muraleedharan Nair Bindhu VK, Naskar K, Nayak A, Sadangi P, Saha P, Swain SK, Varghese S, Vats D, Acharya S, Alpana A, Dube S, Gomber B, Kansal B, Laha A, Sahu B, Sharma S, Bakhshiansohi H, Khazaie E, Zeinali M, Chenarani S, Etesami SM, Khakzad M, Mohammadi Najafabadi M, Grunewald M, Abbrescia M, Aly R, Colaleo A, Creanza D, D'Anzi B, De Filippis N, De Palma M, Di Florio A, Elmetenawee W, Fiore L, Iaselli G, Louka M, Maggi G, Maggi M, Margjeka I, Mastrapasqua V, My S, Nuzzo S, Pellecchia A, Pompili A, Pugliese G, Radogna R, Ramirez-Sanchez G, Ramos D, Ranieri A, Silvestris L, Simone FM, Sözbilir Ü, Stamerra A, Venditti R, Verwilligen P, Zaza A, Abbiendi G, Battilana C, Bonacorsi D, Borgonovi L, Campanini R, Capiluppi P, Castro A, Cavallo FR, Dallavalle GM, Diotalevi T, Fabbri F, Fanfani A, Fasanella D, Giacomelli P, Giommi L, Grandi C, Guiducci L, Lo Meo S, Lunerti L, Marcellini S, Masetti G, Navarria FL, Perrotta A, Primavera F, Rossi AM, Rovelli T, Siroli GP, Costa S, Di Mattia A, Potenza R, Tricomi A, Tuve C, Assiouras P, Barbagli G, Bardelli G, Camaiani B, Cassese A, Ceccarelli R, Ciulli V, Civinini C, D'Alessandro R, Focardi E, Kello T, Latino G, Lenzi P, Lizzo M, Meschini M, Paoletti S, Papanastassiou A, Sguazzoni G, Viliani L, Benussi L, Bianco S, Meola S, Piccolo D, Chatagnon P, Ferro F, Robutti E, Tosi S, Benaglia A, Boldrini G, Brivio F, Cetorelli F, De Guio F, Dinardo ME, Dini P, Gennai S, Gerosa R, Ghezzi A, Govoni P, Guzzi L, Lucchini MT, Malberti M, Malvezzi S, Massironi A, Menasce D, Moroni L, Paganoni M, Pedrini D, Pinolini BS, Ragazzi S, Tabarelli de Fatis T, Zuolo D, Buontempo S, Cagnotta A, Carnevali F, Cavallo N, De Iorio A, Fabozzi F, Iorio AOM, Lista L, Paolucci P, Rossi B, Sciacca C, Ardino R, Azzi P, Bacchetta N, Bisello D, Bortignon P, Bragagnolo A, Carlin R, Checchia P, Dorigo T, Gasparini F, Gasparini U, Gozzelino A, Gulmini M, Lusiani E, Margoni M, Meneguzzo AT, Migliorini M, Pazzini J, Ronchese P, Rossin R, Simonetto F, Strong G, Tosi M, Triossi A, Ventura S, Yarar H, Zotto P, Zucchetta A, Abu Zeid S, Aimè C, Braghieri A, Calzaferri S, Fiorina D, Montagna P, Re V, Riccardi C, Salvini P, Vai I, Vitulo P, Ajmal S, Asenov P, Bilei GM, Ciangottini D, Fanò L, Magherini M, Mantovani G, Mariani V, Menichelli M, Moscatelli F, Rossi A, Santocchia A, Spiga D, Tedeschi T, Azzurri P, Bagliesi G, Bhattacharya R, Bianchini L, Boccali T, Bossini E, Bruschini D, Castaldi R, Ciocci MA, Cipriani M, D'Amante V, Dell'Orso R, Donato S, Giassi A, Ligabue F, Matos Figueiredo D, Messineo A, Musich M, Palla F, Rizzi A, Rolandi G, Roy Chowdhury S, Sarkar T, Scribano A, Spagnolo P, Tenchini R, Tonelli G, Turini N, Venturi A, Verdini PG, Barria P, Campana M, Cavallari F, Cunqueiro Mendez L, Del Re D, Di Marco E, Diemoz M, Errico F, Longo E, Meridiani P, Mijuskovic J, Organtini G, Pandolfi F, Paramatti R, Quaranta C, Rahatlou S, Rovelli C, Santanastasio F, Soffi L, Amapane N, Arcidiacono R, Argiro S, Arneodo M, Bartosik N, Bellan R, Bellora A, Biino C, Cartiglia N, Costa M, Covarelli R, Demaria N, Finco L, 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Phys Rev Lett. 2024 Jan 12. PMID: 38277607.", + "Identification of constrained sequence elements across 239 primate genomes. Kuderna LFK, Ulirsch JC, Rashid S, Ameen M, Sundaram L, Hickey G, Cox AJ, Gao H, Kumar A, Aguet F, Christmas MJ, Clawson H, Haeussler M, Janiak MC, Kuhlwilm M, Orkin JD, Bataillon T, Manu S, Valenzuela A, Bergman J, Rouselle M, Silva FE, Agueda L, Blanc J, Gut M, de Vries D, Goodhead I, Harris RA, Raveendran M, Jensen A, Chuma IS, Horvath JE, Hvilsom C, Juan D, Frandsen P, Schraiber JG, de Melo FR, Bertuol F, Byrne H, Sampaio I, Farias I, Valsecchi J, Messias M, da Silva MNF, Trivedi M, Rossi R, Hrbek T, Andriaholinirina N, Rabarivola CJ, Zaramody A, Jolly CJ, Phillips-Conroy J, Wilkerson G, Abee C, Simmons JH, Fernandez-Duque E, Kanthaswamy S, Shiferaw F, Wu D, Zhou L, Shao Y, Zhang G, Keyyu JD, Knauf S, Le MD, Lizano E, Merker S, Navarro A, Nadler T, Khor CC, Lee J, Tan P, Lim WK, Kitchener AC, Zinner D, Gut I, Melin AD, Guschanski K, Schierup MH, Beck RMD, Karakikes I, Wang KC, Umapathy G, Roos C, Boubli JP, Siepel A, Kundaje A, Paten B, Lindblad-Toh K, Rogers J, Marques Bonet T, Farh KK. Nature. 2024 Jan; 2023 Nov 29. PMID: 38030727.", + "Generation and Manipulation of Rat Intestinal Organoids. Zagoren E, Santos AK, Ameen NA, Sumigray K. J Vis Exp. 2023 Jun 23; 2023 Jun 23. PMID: 37427951.", + "CFTR High Expresser Cells in cystic fibrosis and intestinal diseases. Carlos Dos Reis D, Dastoor P, Santos AK, Sumigray K, Ameen NA. Heliyon. 2023 Mar; 2023 Mar 14. PMID: 36967909.", + "Loss of Serum Glucocorticoid-Inducible Kinase 1 SGK1 Worsens Malabsorption and Diarrhea in Microvillus Inclusion Disease (MVID). Ahsan MK, Dos Reis DC, Barbieri A, Sumigray KD, Nottoli T, Salas PJ, Ameen NA. J Clin Med. 2022 Jul 19; 2022 Jul 19. PMID: 35887942.", + "Intestinal TMEM16A control luminal chloride secretion in a NHERF1 dependent manner. Saha T, Aoun J, Hayashi M, Ali SI, Sarkar P, Bag PK, Leblanc N, Ameen N, Woodward OM, Hoque KM. Biochem Biophys Rep. 2021 Mar; 2021 Jan 22. PMID: 33537462.", + "Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea. Ahsan MK, Figueroa-Hall L, Baratta V, Garcia-Milian R, Lam TT, Hoque K, Salas PJ, Ameen NA. Am J Physiol Gastrointest Liver Physiol. 2020 Aug 1; 2020 Jun 22. PMID: 32567324.", + "Glucocorticoids and myosin5b loss of function induce heightened PKA signaling in addition to membrane traffic defects. Forteza R, Ahsan MK, Cartón-García F, Arango D, Ameen NA, Salas PJ. Mol Biol Cell. 2019 Dec 15; 2019 Oct 30. PMID: 31664880.", + "Zinc ameliorates intestinal barrier dysfunctions in shigellosis by reinstating claudin-2 and -4 on the membranes. Sarkar P, Saha T, Sheikh IA, Chakraborty S, Aoun J, Chakrabarti MK, Rajendran VM, Ameen NA, Dutta S, Hoque KM. Am J Physiol Gastrointest Liver Physiol. 2019 Feb 1; 2018 Nov 8. PMID: 30406698.", + "Loss of MYO5B Leads to Reductions in Na(+) Absorption With Maintenance of CFTR-Dependent Cl(-) Secretion in Enterocytes. Engevik AC, Kaji I, Engevik MA, Meyer AR, Weis VG, Goldstein A, Hess MW, Müller T, Koepsell H, Dudeja PK, Tyska M, Huber LA, Shub MD, Ameen N, Goldenring JR. Gastroenterology. 2018 Dec; 2018 Aug 23. PMID: 30144427.", + "Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine. Ahsan MK, Tchernychev B, Kessler MM, Solinga RM, Arthur D, Linde CI, Silos-Santiago I, Hannig G, Ameen NA. Physiol Rep. 2017 Jun. PMID: 28592587.", + "AP2 α modulates cystic fibrosis transmembrane conductance regulator function in the human intestine. Kumari V, Desai S, Ameen NA. J Cyst Fibros. 2017 May; 2017 Apr 21. PMID: 28438500.", + "Identification of intestinal ion transport defects in microvillus inclusion disease. Kravtsov DV, Ahsan MK, Kumari V, van Ijzendoorn SC, Reyes-Mugica M, Kumar A, Gujral T, Dudeja PK, Ameen NA. Am J Physiol Gastrointest Liver Physiol. 2016 Jul 1; 2016 May 26. PMID: 27229121.", + "Restoration of cytoskeletal and membrane tethering defects but not defects in membrane trafficking in the intestinal brush border of mice lacking both myosin Ia and myosin VI. Hegan PS, Kravtsov DV, Caputo C, Egan ME, Ameen NA, Mooseker MS. Cytoskeleton (Hoboken). 2015 Sep; 2015 Sep 16. PMID: 26286357.", + "Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment. Kravtsov D, Mashukova A, Forteza R, Rodriguez MM, Ameen NA, Salas PJ. Am J Physiol Gastrointest Liver Physiol. 2014 Nov 15; 2014 Sep 25. PMID: 25258405.", + "Functional vacuolar ATPase (V-ATPase) proton pumps traffic to the enterocyte brush border membrane and require CFTR. Collaco AM, Geibel P, Lee BS, Geibel JP, Ameen NA. Am J Physiol Cell Physiol. 2013 Nov 1; 2013 Aug 28. PMID: 23986201.", + "Characterization of CFTR High Expresser cells in the intestine. Jakab RL, Collaco AM, Ameen NA. Am J Physiol Gastrointest Liver Physiol. 2013 Sep 15; 2013 Jul 18. PMID: 23868408.", + "Regulated traffic of anion transporters in mammalian Brunner's glands: a role for water and fluid transport. Collaco AM, Jakab RL, Hoekstra NE, Mitchell KA, Brooks A, Ameen NA. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 1; 2013 Jun 6. PMID: 23744739.", + "Molecular motors and apical CFTR traffic in epithelia. Kravtsov DV, Ameen NA. Int J Mol Sci. 2013 May 3; 2013 May 3. PMID: 23644890.", + "Lubiprostone targets prostanoid signaling and promotes ion transporter trafficking, mucus exocytosis, and contractility. Jakab RL, Collaco AM, Ameen NA. Dig Dis Sci. 2012 Nov; 2012 Aug 25. PMID: 22923315.", + "Myosin Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine. Kravtsov DV, Caputo C, Collaco A, Hoekstra N, Egan ME, Mooseker MS, Ameen NA. Traffic. 2012 Aug; 2012 May 8. PMID: 22510086.", + "Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine. Jakab RL, Collaco AM, Ameen NA. Am J Physiol Gastrointest Liver Physiol. 2011 Jan; 2010 Oct 28. PMID: 21030607.", + "A unique subset of rat and human intestinal villus cells express the cystic fibrosis transmembrane conductance regulator. Ameen NA, Ardito T, Kashgarian M, Marino CR. Gastroenterology. 1995 Apr. PMID: 7535272.", + "The Anlyan Center for Medical Research & Education 300 Cedar Street New Haven, CT 06510", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Arnsten Lab", + "lab_url": "https://medicine.yale.edu/lab/arnsten/", + "research_bio": "INFORMATION FOR The Arnsten Lab studies molecular influences on the higher cognitive circuits of the prefrontal cortex (PFC), with the overarching goal of developing rational treatments for cognitive disorders in aging and mental illness. The lab uses a multi-disciplinary approach to understand mechanisms influencing working memory at the cellular and behavioral levels. Research has focused on how neuromodulators such as norepinephrine (NE), dopamine (DA) and acetycholine (Ach), dynamically modulate PFC network strength through intracellular signaling mechanisms that open or close potassium channels near glutamate NMDA receptor synapses on dendritic spines. We have termed this rapid form of neuroplasticity Dynamic Network Connectivity (DNC). Our data explains how exposure to stress causes the rapid loss of PFC cognitive abilities, and how genetic mutations in molecules that regulate these pathways can lead to symptoms of mental illness. Dysregulation of these pathways with advancing age also contributes to loss of PFC neuronal firing, cognitive deficits and vulnerability for degeneration in Alzheimer’s Disease. Understanding these mechanisms has already led to successful new treatments, including the use of guanfacine (Intuniv™) for a variety of PFC disorders. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/arnsten/publications/", + "publications": [ + "Yale School of Medicine /", + "Neuroscience /", + "Research Prefrontal Networks Dynamic Network Connectivity Molecular Mechanisms The Inverted U Uncontrollable Stress Mental Illness Age-related Cognitive Decline Molecular Mechanisms Guanfacine", + "Prefrontal Networks", + "Dynamic Network Connectivity Molecular Mechanisms", + "Molecular Mechanisms", + "The Inverted U", + "Uncontrollable Stress", + "Mental Illness", + "Age-related Cognitive Decline Molecular Mechanisms", + "Molecular Mechanisms", + "Guanfacine", + "People", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "", + "", + "", + "", + "", + "", + "Ryanodine receptor 2-mediated calcium leak is associated with increased glyoxalase I in the aging brain. Woo E, Datta D, Bathla S, Beatty HE, Caglayan PB, Albizu AK, Lam TT, Kanyo J, Joyce MKP, Leslie SN, Uchendu S, DeLong JH, Guan QS, Li J, Abramson E, Herman AL, Cooper DC, Licznerski P, Horvath TL, Jonas EA, Nairn AC, Arnsten AF, Sansing LH. JCI Insight. 2025 Oct 16; 2025 Oct 16. PMID: 41100182.", + "Kynurenic acid inflammatory signaling expands in primates and impairs prefrontal cortical cognition. Yang S, Datta D, Krienen FM, Ling E, Woo E, May A, Anderson GM, Galvin VC, Gonzalez-Burgos G, Lewis DA, McCarroll SA, Arnsten AF, Wang M. bioRxiv. 2024 Jun 13; 2024 Jun 13. PMID: 38915595.", + "Comparison of [(11)C]UCB-J and [(18)F]FDG PET in Alzheimer's disease: A tracer kinetic modeling study. Chen MK, Mecca AP, Naganawa M, Gallezot JD, Toyonaga T, Mondal J, Finnema SJ, Lin SF, O'Dell RS, McDonald JW, Michalak HR, Vander Wyk B, Nabulsi NB, Huang Y, Arnsten AF, van Dyck CH, Carson RE. J Cereb Blood Flow Metab. 2021 Sep; 2021 Mar 24. PMID: 33757318.", + "M1 receptors interacting with NMDAR enhance delay-related neuronal firing and improve working memory performance. Galvin VC, Yang S, Lowet AS, Datta D, Duque A, Arnsten AF, Wang M. Curr Res Neurobiol. 2021; 2021 Jul 12. PMID: 35098156.", + "Nicotinic α4β2 Cholinergic Receptor Influences on Dorsolateral Prefrontal Cortical Neuronal Firing during a Working Memory Task. Sun Y, Yang Y, Galvin VC, Yang S, Arnsten AF, Wang M. J Neurosci. 2017 May 24; 2017 Apr 27. PMID: 28450546.", + "Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia. Arnsten AF, Girgis RR, Gray DL, Mailman RB. Biol Psychiatry. 2017 Jan 1; 2016 Jan 18. PMID: 26946382.", + "Ketamine's Antidepressant Actions: Potential Mechanisms in the Primate Medial Prefrontal Circuits That Represent Aversive Experience. Arnsten AF, Murray JD, Seo H, Lee D. Biol Psychiatry. 2016 May 1. PMID: 27079495.", + "Ameliorating treatment-refractory depression with intranasal ketamine: potential NMDA receptor actions in the pain circuitry representing mental anguish. Opler LA, Opler MG, Arnsten AF. CNS Spectr. 2016 Feb; 2015 Jan 26. PMID: 25619798.", + "Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology. Abdallah CG, Averill LA, Krystal JH, Southwick SM, Arnsten AF. Behav Brain Sci. 2016 Jan. PMID: 28347382.", + "Targeting Prefrontal Cortical Systems for Drug Development: Potential Therapies for Cognitive Disorders. Arnsten AF, Wang M. Annu Rev Pharmacol Toxicol. 2016. PMID: 26738476.", + "Stress Impairs Prefrontal Cortical Function via D1 Dopamine Receptor Interactions With Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels. Gamo NJ, Lur G, Higley MJ, Wang M, Paspalas CD, Vijayraghavan S, Yang Y, Ramos BP, Peng K, Kata A, Boven L, Lin F, Roman L, Lee D, Arnsten AF. Biol Psychiatry. 2015 Dec 15; 2015 Feb 4. PMID: 25731884.", + "Physiological approaches to understanding molecular actions on dorsolateral prefrontal cortical neurons underlying higher cognitive processing. Wang M, Arnsten AF. Dongwuxue Yanjiu. 2015 Nov 18. PMID: 26646567.", + "Stress weakens prefrontal networks: molecular insults to higher cognition. Arnsten AF. Nat Neurosci. 2015 Oct; 2015 Sep 25. PMID: 26404712.", + "Dopamine's Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders. Arnsten AF, Wang M, Paspalas CD. Pharmacol Rev. 2015 Jul. PMID: 26106146.", + "An Update on Posttraumatic Stress Disorder in Children and Adolescents. Connor DF, Ford JD, Arnsten AF, Greene CA. Clin Pediatr (Phila). 2015 Jun; 2014 Jul 2. PMID: 24990362.", + "Contribution of NMDA receptors to dorsolateral prefrontal cortical networks in primates. Wang M, Arnsten AF. Neurosci Bull. 2015 Apr; 2015 Mar 9. PMID: 25754145.", + "A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation. McKee SA, Potenza MN, Kober H, Sofuoglu M, Arnsten AF, Picciotto MR, Weinberger AH, Ashare R, Sinha R. J Psychopharmacol. 2015 Mar; 2014 Dec 16. PMID: 25516371.", + "Chronic Stimulation of Alpha-2A-Adrenoceptors With Guanfacine Protects Rodent Prefrontal Cortex Dendritic Spines and Cognition From the Effects of Chronic Stress. Hains AB, Yabe Y, Arnsten AF. Neurobiol Stress. 2015. PMID: 25664335.", + "The Effects of Stress Exposure on Prefrontal Cortex: Translating Basic Research into Successful Treatments for Post-Traumatic Stress Disorder. Arnsten AF, Raskind MA, Taylor FB, Connor DF. Neurobiol Stress. 2015 Jan 1. PMID: 25436222.", + "Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels. El-Hassar L, Simen AA, Duque A, Patel KD, Kaczmarek LK, Arnsten AF, Yeckel MF. Biol Psychiatry. 2014 Sep 15; 2014 Jan 20. PMID: 24560582.", + "Guanfacine extended release for the treatment of attention-deficit/hyperactivity disorder in children and adolescents. Connor DF, Arnsten AF, Pearson GS, Greco GF. Expert Opin Pharmacother. 2014 Aug; 2014 Jul 3. PMID: 24992513.", + "cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex. Carlyle BC, Nairn AC, Wang M, Yang Y, Jin LE, Simen AA, Ramos BP, Bordner KA, Craft GE, Davies P, Pletikos M, Šestan N, Arnsten AF, Paspalas CD. Proc Natl Acad Sci U S A. 2014 Apr 1; 2014 Mar 18. PMID: 24707050.", + "Molecular influences on working memory circuits in dorsolateral prefrontal cortex. Arnsten AF, Jin LE. Prog Mol Biol Transl Sci. 2014. PMID: 24484703.", + "Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction. Gamo NJ, Duque A, Paspalas CD, Kata A, Fine R, Boven L, Bryan C, Lo T, Anighoro K, Bermudez L, Peng K, Annor A, Raja A, Mansson E, Taylor SR, Patel K, Simen AA, Arnsten AF. Transl Psychiatry. 2013 Dec 3; 2013 Dec 3. PMID: 24301646.", + "Psychostimulants and motivated behavior: arousal and cognition. Berridge CW, Arnsten AF. Neurosci Biobehav Rev. 2013 Nov; 2012 Nov 16. PMID: 23164814.", + "The neurobiology of thought: the groundbreaking discoveries of Patricia Goldman-Rakic 1937-2003. Arnsten AF. Cereb Cortex. 2013 Oct; 2013 Aug 7. PMID: 23926115.", + "Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex. Yang Y, Paspalas CD, Jin LE, Picciotto MR, Arnsten AF, Wang M. Proc Natl Acad Sci U S A. 2013 Jul 16; 2013 Jul 1. PMID: 23818597.", + "Constellation of HCN channels and cAMP regulating proteins in dendritic spines of the primate prefrontal cortex: potential substrate for working memory deficits in schizophrenia. Paspalas CD, Wang M, Arnsten AF. Cereb Cortex. 2013 Jul; 2012 Jun 12. PMID: 22693343.", + "NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex. Wang M, Yang Y, Wang CJ, Gamo NJ, Jin LE, Mazer JA, Morrison JH, Wang XJ, Arnsten AF. Neuron. 2013 Feb 20. PMID: 23439125.", + "Noradrenergic control of error perseveration in medial prefrontal cortex. Caetano MS, Jin LE, Harenberg L, Stachenfeld KL, Arnsten AF, Laubach M. Front Integr Neurosci. 2012; 2013 Jan 2. PMID: 23293590.", + "Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses. Arnsten AF, Wang MJ, Paspalas CD. Neuron. 2012 Oct 4. PMID: 23040817.", + "Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: disruptions in neurodevelopmental psychiatric disorders. Arnsten AF, Rubia K. J Am Acad Child Adolesc Psychiatry. 2012 Apr; 2012 Mar 3. PMID: 22449642.", + "Lost in transition: aging-related changes in executive control by the medial prefrontal cortex. Caetano MS, Horst NK, Harenberg L, Liu B, Arnsten AF, Laubach M. J Neurosci. 2012 Mar 14. PMID: 22423097.", + "Guanfacine for the treatment of cognitive disorders: a century of discoveries at Yale. Arnsten AF, Jin LE. Yale J Biol Med. 2012 Mar; 2012 Mar 29. PMID: 22461743.", + "Effects of α-2A adrenergic receptor agonist on time and risk preference in primates. Kim S, Bobeica I, Gamo NJ, Arnsten AF, Lee D. Psychopharmacology (Berl). 2012 Jan; 2011 Oct 7. PMID: 21979441.", + "Catecholamine influences on prefrontal cortical function: relevance to treatment of attention deficit/hyperactivity disorder and related disorders. Arnsten AF, Pliszka SR. Pharmacol Biochem Behav. 2011 Aug; 2011 Feb 2. PMID: 21295057.", + "Neuronal basis of age-related working memory decline. Wang M, Gamo NJ, Yang Y, Jin LE, Wang XJ, Laubach M, Mazer JA, Lee D, Arnsten AF. Nature. 2011 Jul 27; 2011 Jul 27. PMID: 21796118.", + "Prefrontal cortical organization and function: implications for externalizing disorders. Arnsten AF, Casey BJ. Biol Psychiatry. 2011 Jun 15. PMID: 21640860.", + "Catecholamine influences on dorsolateral prefrontal cortical networks. Arnsten AF. Biol Psychiatry. 2011 Jun 15; 2011 Apr 13. PMID: 21489408.", + "Molecular modulation of prefrontal cortex: rational development of treatments for psychiatric disorders. Gamo NJ, Arnsten AF. Behav Neurosci. 2011 Jun. PMID: 21480691.", + "Prefrontal cortical network connections: key site of vulnerability in stress and schizophrenia. Arnsten AF. Int J Dev Neurosci. 2011 May; 2011 Feb 21. PMID: 21345366.", + "The use of α-2A adrenergic agonists for the treatment of attention-deficit/hyperactivity disorder. Arnsten AF. Expert Rev Neurother. 2010 Oct. PMID: 20925474.", + "Methylphenidate and atomoxetine enhance prefrontal function through α2-adrenergic and dopamine D1 receptors. Gamo NJ, Wang M, Arnsten AF. J Am Acad Child Adolesc Psychiatry. 2010 Oct; 2010 Sep 1. PMID: 20855046.", + "Dynamic Network Connectivity: A new form of neuroplasticity. Arnsten AF, Paspalas CD, Gamo NJ, Yang Y, Wang M. Trends Cogn Sci. 2010 Aug; 2010 Jun 16. PMID: 20554470.", + "Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress. Hains AB, Vu MA, Maciejewski PK, van Dyck CH, Gottron M, Arnsten AF. Proc Natl Acad Sci U S A. 2009 Oct 20; 2009 Sep 11. PMID: 19805148.", + "Mapping the regulator of G protein signaling 4 (RGS4): presynaptic and postsynaptic substrates for neuroregulation in prefrontal cortex. Paspalas CD, Selemon LD, Arnsten AF. Cereb Cortex. 2009 Sep; 2009 Jan 19. PMID: 19153107.", + "Estrogen prevents norepinephrine alpha-2a receptor reversal of stress-induced working memory impairment. Shansky RM, Bender G, Arnsten AF. Stress. 2009 Sep. PMID: 19005873.", + "Stress signalling pathways that impair prefrontal cortex structure and function. Arnsten AF. Nat Rev Neurosci. 2009 Jun. PMID: 19455173.", + "The Emerging Neurobiology of Attention Deficit Hyperactivity Disorder: The Key Role of the Prefrontal Association Cortex. Arnsten AF. J Pediatr. 2009 May 1. PMID: 20596295.", + "Protein kinase C activity is associated with prefrontal cortical decline in aging. Brennan AR, Yuan P, Dickstein DL, Rocher AB, Hof PR, Manji H, Arnsten AF. Neurobiol Aging. 2009 May; 2007 Oct 4. PMID: 17919783.", + "Primate models of schizophrenia: future possibilities. Simen AA, DiLeone R, Arnsten AF. Prog Brain Res. 2009; 2009 Nov 20. PMID: 20302824.", + "Toward a new understanding of attention-deficit hyperactivity disorder pathophysiology: an important role for prefrontal cortex dysfunction. Arnsten AF. CNS Drugs. 2009. PMID: 19621976.", + "The neuropsychopharmacology of fronto-executive function: monoaminergic modulation. Robbins TW, Arnsten AF. Annu Rev Neurosci. 2009. PMID: 19555290.", + "Ameliorating prefrontal cortical dysfunction in mental illness: inhibition of phosphotidyl inositol-protein kinase C signaling. Arnsten AF. Psychopharmacology (Berl). 2009 Jan; 2008 Aug 22. PMID: 18719894.", + "Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. Budel S, Padukkavidana T, Liu BP, Feng Z, Hu F, Johnson S, Lauren J, Park JH, McGee AW, Liao J, Stillman A, Kim JE, Yang BZ, Sodi S, Gelernter J, Zhao H, Hisama F, Arnsten AF, Strittmatter SM. J Neurosci. 2008 Dec 3. PMID: 19052207.", + "Molecular mechanisms of stress-induced prefrontal cortical impairment: implications for mental illness. Hains AB, Arnsten AF. Learn Mem. 2008 Aug; 2008 Aug 6. PMID: 18685145.", + "Striatal dopamine transporters correlate with simple reaction time in elderly subjects. van Dyck CH, Avery RA, MacAvoy MG, Marek KL, Quinlan DM, Baldwin RM, Seibyl JP, Innis RB, Arnsten AF. Neurobiol Aging. 2008 Aug; 2007 Mar 23. PMID: 17363113.", + "Beta2 adrenergic agonist, clenbuterol, enhances working memory performance in aging animals. Ramos BP, Colgan LA, Nou E, Arnsten AF. Neurobiol Aging. 2008 Jul; 2007 Mar 23. PMID: 17363115.", + "Blockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory. Brennan AR, Dolinsky B, Vu MA, Stanley M, Yeckel MF, Arnsten AF. Learn Mem. 2008 Mar; 2008 Feb 19. PMID: 18285467.", + "Neuronal mechanisms underlying attention deficit hyperactivity disorder: the influence of arousal on prefrontal cortical function. Brennan AR, Arnsten AF. Ann N Y Acad Sci. 2008. PMID: 18591484.", + "Catecholamine and second messenger influences on prefrontal cortical networks of \"representational knowledge\": a rational bridge between genetics and the symptoms of mental illness. Arnsten AF. Cereb Cortex. 2007 Sep; 2007 Apr 13. PMID: 17434919.", + "alpha2-Adrenergic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: emerging concepts from new data. Arnsten AF, Scahill L, Findling RL. J Child Adolesc Psychopharmacol. 2007 Aug. PMID: 17822336.", + "Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Wang M, Ramos BP, Paspalas CD, Shu Y, Simen A, Duque A, Vijayraghavan S, Brennan A, Dudley A, Nou E, Mazer JA, McCormick DA, Arnsten AF. Cell. 2007 Apr 20. PMID: 17448997.", + "Adrenergic pharmacology and cognition: focus on the prefrontal cortex. Ramos BP, Arnsten AF. Pharmacol Ther. 2007 Mar; 2006 Dec 28. PMID: 17303246.", + "Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Vijayraghavan S, Wang M, Birnbaum SG, Williams GV, Arnsten AF. Nat Neurosci. 2007 Mar; 2007 Feb 4. PMID: 17277774.", + "Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function. Berridge CW, Devilbiss DM, Andrzejewski ME, Arnsten AF, Kelley AE, Schmeichel B, Hamilton C, Spencer RC. Biol Psychiatry. 2006 Nov 15; 2006 Jun 23. PMID: 16806100.", + "Alpha2A-adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of cAMP signaling in aging animals. Ramos BP, Stark D, Verduzco L, van Dyck CH, Arnsten AF. Learn Mem. 2006 Nov-Dec; 2006 Nov 13. PMID: 17101879.", + "Stimulants: Therapeutic actions in ADHD. Arnsten AF. Neuropsychopharmacology. 2006 Nov; 2006 Jul 19. PMID: 16855530.", + "Staying in touch with methylphenidate: AHDH and sensory processing. Focus on \"methylphenidate enhances noradrenergic transmission and suppresses mid- and long-latency sensory responses in the primary somatosensory cortex of awake rats\". Arnsten AF, Vijayraghavan S. J Neurophysiol. 2006 Aug. PMID: 16835361.", + "The effects of sex and hormonal status on restraint-stress-induced working memory impairment. Shansky RM, Rubinow K, Brennan A, Arnsten AF. Behav Brain Funct. 2006 Mar 7; 2006 Mar 7. PMID: 16522198.", + "Fundamentals of attention-deficit/hyperactivity disorder: circuits and pathways. Arnsten AF. J Clin Psychiatry. 2006. PMID: 16961424.", + "New developments in the treatment of ADHD. Biederman J, Arnsten AF, Faraone SV, Doyle AE, Spencer TJ, Wilens TE, Weiss MD, Safren SA, Culpepper L. J Clin Psychiatry. 2006 Jan. PMID: 16426101.", + "The beta-1 adrenergic antagonist, betaxolol, improves working memory performance in rats and monkeys. Ramos BP, Colgan L, Nou E, Ovadia S, Wilson SR, Arnsten AF. Biol Psychiatry. 2005 Dec 1; 2005 Jul 25. PMID: 16043136.", + "Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions. Arnsten AF, Li BM. Biol Psychiatry. 2005 Jun 1. PMID: 15950011.", + "Methylphenidate improves prefrontal cortical cognitive function through alpha2 adrenoceptor and dopamine D1 receptor actions: Relevance to therapeutic effects in Attention Deficit Hyperactivity Disorder. Arnsten AF, Dudley AG. Behav Brain Funct. 2005 Apr 22; 2005 Apr 22. PMID: 15916700.", + "Protein kinase A as a therapeutic target for memory disorders: rationale and challenges. Arnsten AF, Ramos BP, Birnbaum SG, Taylor JR. Trends Mol Med. 2005 Mar. PMID: 15760770.", + "Locomotor hyperactivity induced by blockade of prefrontal cortical alpha2-adrenoceptors in monkeys. Ma CL, Arnsten AF, Li BM. Biol Psychiatry. 2005 Jan 15. PMID: 15652880.", + "Protein kinase C overactivity impairs prefrontal cortical regulation of working memory. Birnbaum SG, Yuan PX, Wang M, Vijayraghavan S, Bloom AK, Davis DJ, Gobeske KT, Sweatt JD, Manji HK, Arnsten AF. Science. 2004 Oct 29. PMID: 15514161.", + "Adolescence: vulnerable period for stress-induced prefrontal cortical function? Introduction to part IV. Arnsten AF, Shansky RM. Ann N Y Acad Sci. 2004 Jun. PMID: 15251883.", + "Adrenergic targets for the treatment of cognitive deficits in schizophrenia. Arnsten AF. Psychopharmacology (Berl). 2004 Jun; 2003 Dec 19. PMID: 15205875.", + "Estrogen mediates sex differences in stress-induced prefrontal cortex dysfunction. Shansky RM, Glavis-Bloom C, Lerman D, McRae P, Benson C, Miller K, Cosand L, Horvath TL, Arnsten AF. Mol Psychiatry. 2004 May. PMID: 14569273.", + "Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline. Ramos BP, Birnbaum SG, Lindenmayer I, Newton SS, Duman RS, Arnsten AF. Neuron. 2003 Nov 13. PMID: 14622586.", + "D1 dopamine receptors in the mouse prefrontal cortex: Immunocytochemical and cognitive neuropharmacological analyses. Lidow MS, Koh PO, Arnsten AF. Synapse. 2003 Feb. PMID: 12454947.", + "Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine. Franowicz JS, Kessler LE, Borja CM, Kobilka BK, Limbird LE, Arnsten AF. J Neurosci. 2002 Oct 1. PMID: 12351753.", + "Actions of alpha-2 noradrenergic agonists on spatial working memory and blood pressure in rhesus monkeys appear to be mediated by the same receptor subtype. Franowicz JS, Arnsten AF. Psychopharmacology (Berl). 2002 Jul; 2002 Jun 13. PMID: 12122489.", + "A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. Scahill L, Chappell PB, Kim YS, Schultz RT, Katsovich L, Shepherd E, Arnsten AF, Cohen DJ, Leckman JF. Am J Psychiatry. 2001 Jul. PMID: 11431228.", + "Modulation of prefrontal cortical-striatal circuits: relevance to therapeutic treatments for Tourette syndrome and attention-deficit hyperactivity disorder. Arnsten AF. Adv Neurol. 2001. PMID: 11530441.", + "Noradrenergic alpha-2 receptor agonists reverse working memory deficits induced by the anxiogenic drug, FG7142, in rats. Birnbaum SG, Podell DM, Arnsten AF. Pharmacol Biochem Behav. 2000 Nov. PMID: 11164065.", + "The selective dopamine D4 receptor antagonist, PNU-101387G, prevents stress-induced cognitive deficits in monkeys. Arnsten AF, Murphy B, Merchant K. Neuropsychopharmacology. 2000 Oct. PMID: 10989267.", + "Genetics of childhood disorders: XVIII. ADHD, Part. 2: Norepinephrine has a critical modulatory influence on prefrontal cortical function. Arnsten AF. J Am Acad Child Adolesc Psychiatry. 2000 Sep. PMID: 10986819.", + "The alpha-2A-adrenoceptor agonist, guanfacine, increases regional cerebral blood flow in dorsolateral prefrontal cortex of monkeys performing a spatial working memory task. Avery RA, Franowicz JS, Studholme C, van Dyck CH, Arnsten AF. Neuropsychopharmacology. 2000 Sep. PMID: 10942848.", + "Use of guanfacine to control self-injurious behavior in two rhesus macaques (Macaca mulatta) and one baboon (Papio anubis). Macy JD Jr, Beattie TA, Morgenstern SE, Arnsten AF. Comp Med. 2000 Aug. PMID: 11020162.", + "Stress impairs prefrontal cortical function in rats and monkeys: role of dopamine D1 and norepinephrine alpha-1 receptor mechanisms. Arnsten AF. Prog Brain Res. 2000. PMID: 11105647.", + "Through the looking glass: differential noradenergic modulation of prefrontal cortical function. Arnsten AF. Neural Plast. 2000. PMID: 10709220.", + "A role for norepinephrine in stress-induced cognitive deficits: alpha-1-adrenoceptor mediation in the prefrontal cortex. Birnbaum S, Gobeske KT, Auerbach J, Taylor JR, Arnsten AF. Biol Psychiatry. 1999 Nov 1. PMID: 10560032.", + "Local infusion of an alpha-1 adrenergic agonist into the prefrontal cortex impairs spatial working memory performance in monkeys. Mao ZM, Arnsten AF, Li BM. Biol Psychiatry. 1999 Nov 1. PMID: 10560031.", + "Treatment with the noradrenergic alpha-2 agonist clonidine, but not diazepam, improves spatial working memory in normal young rhesus monkeys. Franowicz JS, Arnsten AF. Neuropsychopharmacology. 1999 Nov. PMID: 10516957.", + "Activation of cAMP-dependent protein kinase A in prefrontal cortex impairs working memory performance. Taylor JR, Birnbaum S, Ubriani R, Arnsten AF. J Neurosci. 1999 Sep 15. PMID: 10479716.", + "Development of the cerebral cortex: XIV. Stress impairs prefrontal cortical function. Arnsten AF. J Am Acad Child Adolesc Psychiatry. 1999 Feb. PMID: 9951224.", + "[Roles of alpha-2 adrenoceptor in prefrontal cortical cognitive functions]. Mao ZM, Li BM, Arnsten AF. Sheng Li Ke Xue Jin Zhan. 1999 Jan. PMID: 12532843.", + "", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Bahtiyar Lab", + "lab_url": "https://medicine.yale.edu/lab/bahtiyar/", + "research_bio": "INFORMATION FOR Copy Link Yale University School of MedicineHigh-Risk Pregnancy Clinic: Yale Maternal-Fetal Medicine (High Risk Pregnancy) service practice is a group consisting of 14 experts and seven chief resident physician. All births are carried out in theYale-New Haven Hospital. In addition, four consultation services in Connecticut state borders are provided in separate hospitals. For more information, accesshttps://medicine.yale.edu/obgyn/. Copy Link Yale Üniversitesi Tip FakültesiYüksek Riskli Gebelik Klinigi: Yale Üniversitesi Maternal-Fetal Medicine (Yüksek Riskli Gebelik) servisi 14 uzman hekim ve 7 bas asistandan olusan bir group practice’dir. Tüm dogumlar grup tarafindanYale-New Haven Hastanesi’nde yapilmaktadir. Buna ek olarak, Connecticut eyaleti sinirlarinda dört ayri hastanede konsültasyon hizmeti verilmektedir. Daha detayli bilgi içinhttps://medicine.yale.edu/obgyn/adresinden faydalanabilirsiniz. HASTA BILGI FORMUHasta bilgi formunun tümünü görmek için lutfen burayatiklayin. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/bahtiyar/publications", + "publications": [ + "Yale School of Medicine /", + "Obstetrics, Gynecology & Reproductive Sciences /", + "Publications", + "Podcast", + "Contact Us", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Publications", + "Podcast", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Campbell KH, Copel JA, Bahtiyar MO . Congenital heart defects in twin gestations. Miverva Ginecol 2009;61(3):239-44.", + "Bahtiyar MO , Copel JA. Cardiac Changes in the Intrauterine Growth-Restricted Fetus, Semin Perinatol 2008;32:190-193.", + "Bahtiyar MO , Dulay AT, Weeks BP, Friedman AH, Copel JA. Prenatal course of isolated muscular ventricular septal defects diagnosed only by color Doppler sonography: Single-institution experience. J Ultrasound Med 2008;27:715-720.", + "Bahtiyar MO , Dulay AT, Weeks BP, Friedman AH, Copel JA. Prevalence of congenital heart defects in monochorionic/diamniotic twin gestations. A systematic literature review. J Ultrasound Med 2007;26:1491-1498.", + "Bahtiyar MO , Buhimschi C, Ravishankar V, Copel JA, Norwitz ER, Julien S, Guller S, Buhimschi IA. Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction. Am J Obstet Gynecol 2007;196:72.e1-72.e6.", + "Bahtiyar MO , Julien S, Robinson JN, Lumey L, Zybert P, Copel JA, Lockwood CJ, Norwitz ER. Prior cesarean delivery is not associated with an increased risk of stillbirth in a subsequent pregnancy: Analysis of U.S. perinatal mortality data, 1995-1997. Am J Obstet Gynecol. 2006;195:1373-1378.", + "Office 203.737.1982", + "Fax 203.785.6885", + "Appt 877.925.3637", + "Clinic Fax 203.688.2806", + "Yale New Haven Hospital 20 York Street New Haven, CT 06520-8023", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Bamford Lab", + "lab_url": "https://medicine.yale.edu/lab/bamford/", + "research_bio": "INFORMATION FOR The neocortex and basal ganglia operate together through cortico-basal ganglia-thalamocortical circuits to execute movements and goal directed behaviors. The neocortex communicates with the basal ganglia through parallel sets of glutamatergic corticostriatal projections that synapse on striatal medium-sized spiny neurons. These excitatory signals are modified at the medium spiny neuron by dopamine, released from midbrain projections and by acetylcholine released from striatal interneurons. Combined, these neurotransmitters provoke state changes in medium spiny neurons and determine whether signalling proceeds through direct or indirect striatal pathways that ultimately determine basal ganglia output. Neurodevelopmental and neurodegenerative disorders that affect motor function are associated with abnormal activation of the corticostriatal pathway. The abnormal release of dopamine, acetylcholine and glutamate have been implicated in numerous childhood diseases including juvenile Parkinson's disease, L- dopa-responsive dystonia, drug dependence, Huntington's disease, Tourette syndrome and obsessive compulsive disorder . Our laboratory has examined how alterations in dopamine, acetylcholine and glutamate might produce bradykinesia in parkinsonism, hyperkinesias in drug dependence and progressive motor degeneration in Huntington's disease. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/bamford/publications", + "publications": [ + "Yale School of Medicine /", + "Neurology /", + "Research", + "Staff Previous Lab Trainees", + "Previous Lab Trainees", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Staff", + "Publications", + "", + "", + "", + "", + "", + "", + "Levodopa for Dystonia in Children: A Case Series and Review of the Literature. DeArias AL, Bamford NS. Pediatr Neurol. 2024 Mar; 2023 Dec 19. PMID: 38176223.", + "Neonatal Human Parechovirus Encephalitis: A Case of Rapid and Fatal Gliosis. DeArias AL, McAllister L, Bamford NS. Pediatr Neurol. 2023 Mar; 2022 Dec 5. PMID: 36577180.", + "A 1-Tesla MRI system for dedicated brain imaging in the neonatal intensive care unit. Berson ER, Mozayan A, Peterec S, Taylor SN, Bamford NS, Ment LR, Rowe E, Lisse S, Ehrlich L, Silva CT, Goodman TR, Payabvash S. Front Neurosci. 2023; 2023 Feb 10. PMID: 36845429.", + "Age-dependent white matter microstructural disintegrity in autism spectrum disorder. Weber CF, Lake EMR, Haider SP, Mozayan A, Mukherjee P, Scheinost D, Bamford NS, Ment L, Constable T, Payabvash S. Front Neurosci. 2022; 2022 Sep 7. PMID: 36161157.", + "Control of exploration, motor coordination and amphetamine sensitization by cannabinoid CB(1) receptors expressed in medium spiny neurons. Bonm AV, Elezgarai I, Gremel CM, Viray K, Bamford NS, Palmiter RD, Grandes P, Lovinger DM, Stella N. Eur J Neurosci. 2021 Aug; 2021 Jul 13. PMID: 34216157.", + "Propranolol Relieves L-Dopa-Induced Dyskinesia in Parkinsonian Mice. Shi Z, Bamford IJ, McKinley JW, Devi SPS, Vahedipour A, Bamford NS. Brain Sci. 2020 Nov 24; 2020 Nov 24. PMID: 33255421.", + "Localising movement disorders in childhood. Bamford NS, McVicar K. Lancet Child Adolesc Health. 2019 Dec; 2019 Oct 22. PMID: 31653548.", + "Corticostriatal plasticity in the nucleus accumbens core. Bamford NS, Wang W. J Neurosci Res. 2019 Dec; 2019 Jul 12. PMID: 31298422.", + "Role of KCNQ potassium channels in stress-induced deficit of working memory. Arnsten AFT, Jin LE, Gamo NJ, Ramos B, Paspalas CD, Morozov YM, Kata A, Bamford NS, Yeckel MF, Kaczmarek LK, El-Hassar L. Neurobiol Stress. 2019 Nov; 2019 Jul 26. PMID: 31832507.", + "The Striatum's Role in Executing Rational and Irrational Economic Behaviors. Bamford IJ, Bamford NS. Neuroscientist. 2019 Oct; 2019 Jan 24. PMID: 30678530.", + "Dopamine Deficiency Reduces Striatal Cholinergic Interneuron Function in Models of Parkinson's Disease. McKinley JW, Shi Z, Kawikova I, Hur M, Bamford IJ, Sudarsana Devi SP, Vahedipour A, Darvas M, Bamford NS. Neuron. 2019 Sep 25; 2019 Jul 16. PMID: 31324539.", + "Correspondence Reply to Kitaoka et al. Bamford NS. Pediatr Neurol. 2019 Sep; 2019 Apr 24. PMID: 31113714.", + "Chondrodysplasia Punctata: A Clue to the Zellweger Spectrum Disorders. Bamford NS. Pediatr Neurol. 2019 Jun; 2019 Feb 2. PMID: 30898411.", + "Loss of glutamate signaling from the thalamus to dorsal striatum impairs motor function and slows the execution of learned behaviors. Melief EJ, McKinley JW, Lam JY, Whiteley NM, Gibson AW, Neumaier JF, Henschen CW, Palmiter RD, Bamford NS, Darvas M. NPJ Parkinsons Dis. 2018; 2018 Aug 2. PMID: 30083593.", + "Pearls & Oy-sters: Alternating hemiplegia of childhood mimics focal epilepsy and paroxysmal dyskinesia in infancy. Dhakar MB, Bamford NS. Neurology. 2018 Jul 3. PMID: 29967203.", + "Dopamine's Effects on Corticostriatal Synapses during Reward-Based Behaviors. Bamford NS, Wightman RM, Sulzer D. Neuron. 2018 Feb 7. PMID: 29420932.", + "Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice(1,2,3). Storey GP, Gonzalez-Fernandez G, Bamford IJ, Hur M, McKinley JW, Heimbigner L, Minasyan A, Walwyn WM, Bamford NS. eNeuro. 2016 Jan-Feb; 2016 Feb 2. PMID: 26866057.", + "Dopamine-dependent corticostriatal synaptic filtering regulates sensorimotor behavior. Wong MY, Borgkvist A, Choi SJ, Mosharov EV, Bamford NS, Sulzer D. Neuroscience. 2015 Apr 2; 2015 Jan 28. PMID: 25637802.", + "Acetylcholine encodes long-lasting presynaptic plasticity at glutamatergic synapses in the dorsal striatum after repeated amphetamine exposure. Wang W, Darvas M, Storey GP, Bamford IJ, Gibbs JT, Palmiter RD, Bamford NS. J Neurosci. 2013 Jun 19. PMID: 23785153.", + "Overinhibition of corticostriatal activity following prenatal cocaine exposure. Wang W, Nitulescu I, Lewis JS, Lemos JC, Bamford IJ, Posielski NM, Storey GP, Phillips PE, Bamford NS. Ann Neurol. 2013 Mar; 2012 Dec 7. PMID: 23225132.", + "Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors. Quintana A, Sanz E, Wang W, Storey GP, Güler AD, Wanat MJ, Roller BA, La Torre A, Amieux PS, McKnight GS, Bamford NS, Palmiter RD. Nat Neurosci. 2012 Nov; 2012 Oct 14. PMID: 23064379.", + "Regulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core. Wang W, Dever D, Lowe J, Storey GP, Bhansali A, Eck EK, Nitulescu I, Weimer J, Bamford NS. J Physiol. 2012 Aug 15; 2012 May 14. PMID: 22586226.", + "Prospective trial of a pediatric ventricular assist device. Fraser CD Jr, Jaquiss RD, Rosenthal DN, Humpl T, Canter CE, Blackstone EH, Naftel DC, Ichord RN, Bomgaars L, Tweddell JS, Massicotte MP, Turrentine MW, Cohen GA, Devaney EJ, Pearce FB, Carberry KE, Kroslowitz R, Almond CS. N Engl J Med. 2012 Aug 9. PMID: 22873533.", + "Attenuating GABA(A) receptor signaling in dopamine neurons selectively enhances reward learning and alters risk preference in mice. Parker JG, Wanat MJ, Soden ME, Ahmad K, Zweifel LS, Bamford NS, Palmiter RD. J Neurosci. 2011 Nov 23. PMID: 22114279.", + "Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization. Beutler LR, Wanat MJ, Quintana A, Sanz E, Bamford NS, Zweifel LS, Palmiter RD. Proc Natl Acad Sci U S A. 2011 Mar 8; 2011 Feb 22. PMID: 21368124.", + "Imaging presynaptic exocytosis in corticostriatal slices. Wong MY, Sulzer D, Bamford NS. Methods Mol Biol. 2011. PMID: 21913113.", + "Neuromuscular hip dysplasia in Charcot-Marie-Tooth disease type 1A. Bamford NS, White KK, Robinett SA, Otto RK, Gospe SM Jr. Dev Med Child Neurol. 2009 May. PMID: 19388151.", + "Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease. Joshi PR, Wu NP, André VM, Cummings DM, Cepeda C, Joyce JA, Carroll JB, Leavitt BR, Hayden MR, Levine MS, Bamford NS. J Neurosci. 2009 Feb 25. PMID: 19244517.", + "Repeated exposure to methamphetamine causes long-lasting presynaptic corticostriatal depression that is renormalized with drug readministration. Bamford NS, Zhang H, Joyce JA, Scarlis CA, Hanan W, Wu NP, André VM, Cohen R, Cepeda C, Levine MS, Harleton E, Sulzer D. Neuron. 2008 Apr 10. PMID: 18400166.", + "Dopamine modulates release from corticostriatal terminals. Bamford NS, Robinson S, Palmiter RD, Joyce JA, Moore C, Meshul CK. J Neurosci. 2004 Oct 27. PMID: 15509741.", + "Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals. Bamford NS, Zhang H, Schmitz Y, Wu NP, Cepeda C, Levine MS, Schmauss C, Zakharenko SS, Zablow L, Sulzer D. Neuron. 2004 May 27. PMID: 15157425.", + "Congenital Guillain-Barré syndrome associated with maternal inflammatory bowel disease is responsive to intravenous immunoglobulin. Bamford NS, Trojaborg W, Sherbany AA, De Vivo DC. Eur J Paediatr Neurol. 2002. PMID: 11995958.", + "Varicella-zoster virus retrobulbar optic neuritis in a patient with human immunodeficiency virus. Shayegani A, Odel JG, Kazim M, Hall LS, Bamford N, Schubert H. Am J Ophthalmol. 1996 Oct. PMID: 8862063.", + "Laboratory for Medicine & Pediatrics 15 York Street New Haven, CT 06520 Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Belfort De Aguiar Lab", + "lab_url": "https://medicine.yale.edu/lab/belfort/", + "research_bio": "INFORMATION FOR Our mission: To investigate whether lactation improves insulin sensitivity and increases lipolysis in women. To achieve our mission, we conduct rigorous high-quality clinic and lab to study the mechanisms of insulin resistance and insulin secretion. Copy Link Aim 1:Does lactation improve insulin sensitivity and increase lipolysis in women? In this Aim, we will assess whether lactation amongst women with a history of GDM will improve whole body insulin sensitivity as well as increase whole body lipid turnover by using hyperinsulinemic-euglycemic clamps combined with [6,6-2H]-glucose and [2H5]-glycerol infusions. These stable, non-radiating isotopes have been used extensively and safely to study the mechanisms of insulin resistance amongst non-pregnant as well as pregnant humans; however, these techniques have not previously been applied to the study of insulin sensitivity during lactation. Our goals will be two-fold: Aim 2:Retrospective chart review of women with a history of GDM who had an OGTT 6-8 weeks post-partum as part of standard of care at Yale Medicine’s Maternal-Fetal Medicine Clinic. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/belfort/pubs/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Endocrinology /", + "Lab Members", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Lab Members", + "Publications", + "", + "", + "", + "", + "", + "", + "Measurement of brain glucose metabolism in obesity and diabetes. Hwang JJ, Bini J, Belfort-DeAguiar R. Diabetologia. 2025 Sep; 2025 Jul 25. PMID: 40711543.", + "Pharmacotherapies for Binge Eating Disorder: Systematic Review and Network Meta-Analysis. Costa GPA, Assunção BR, Belfort-DeAguiar R, Nunes JC. Obes Rev. 2025 Sep; 2025 May 8. PMID: 40344489.", + "Low-calorie diet-induced weight loss is associated with altered brain connectivity and food desire in obesity. Hoang H, Lacadie C, Hwang J, Lam K, Elshafie A, Rosenberg SB, Watt C, Sinha R, Constable RT, Savoye M, Seo D, Belfort-DeAguiar R. Obesity (Silver Spring). 2024 Jul; 2024 Jun 3. PMID: 38831482.", + "A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, Romero D, Abdelmalek MF, Anstee QM, Arab JP, Arrese M, Bataller R, Beuers U, Boursier J, Bugianesi E, Byrne CD, Castro Narro GE, Chowdhury A, Cortez-Pinto H, Cryer DR, Cusi K, El-Kassas M, Klein S, Eskridge W, Fan J, Gawrieh S, Guy CD, Harrison SA, Kim SU, Koot BG, Korenjak M, Kowdley KV, Lacaille F, Loomba R, Mitchell-Thain R, Morgan TR, Powell EE, Roden M, Romero-Gómez M, Silva M, Singh SP, Sookoian SC, Spearman CW, Tiniakos D, Valenti L, Vos MB, Wong VW, Xanthakos S, Yilmaz Y, Younossi Z, Hobbs A, Villota-Rivas M, Newsome PN. Hepatology. 2023 Dec 1; 2023 Jun 24. PMID: 37363821.", + "A global research priority agenda to advance public health responses to fatty liver disease. Lazarus JV, Mark HE, Allen AM, Arab JP, Carrieri P, Noureddin M, Alazawi W, Alkhouri N, Alqahtani SA, Arrese M, Bataller R, Berg T, Brennan PN, Burra P, Castro-Narro GE, Cortez-Pinto H, Cusi K, Dedes N, Duseja A, Francque SM, Hagström H, Huang TT, Wajcman DI, Kautz A, Kopka CJ, Krag A, Miller V, Newsome PN, Rinella ME, Romero D, Sarin SK, Silva M, Spearman CW, Tsochatzis EA, Valenti L, Villota-Rivas M, Zelber-Sagi S, Schattenberg JM, Wong VW, Younossi ZM. J Hepatol. 2023 Sep; 2023 Jun 20. PMID: 37353401.", + "Approach to the Patient With Nonalcoholic Fatty Liver Disease. Belfort-DeAguiar R, Lomonaco R, Cusi K. J Clin Endocrinol Metab. 2023 Jan 17. PMID: 36305273.", + "PPAR-γ-induced changes in visceral fat and adiponectin levels are associated with improvement of steatohepatitis in patients with NASH. Gastaldelli A, Sabatini S, Carli F, Gaggini M, Bril F, Belfort-DeAguiar R, Positano V, Barb D, Kadiyala S, Harrison S, Cusi K. Liver Int. 2021 Nov; 2021 Jul 21. PMID: 34219361.", + "Implementing a pharmacist-led transition of care model for posttransplant hyperglycemia. Do V, Haakinson D, Belfort-DeAguiar R, Cohen E. Am J Health Syst Pharm. 2021 Jun 23. PMID: 33821878.", + "Norepinephrine transporter availability in brown fat is reduced in obesity: a human PET study with [(11)C] MRB. Sanchez-Rangel E, Gallezot JD, Yeckel CW, Lam W, Belfort-DeAguiar R, Chen MK, Carson RE, Sherwin R, Hwang JJ. Int J Obes (Lond). 2020 Apr; 2019 Oct 21. PMID: 31636373.", + "Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes. Parikh L, Seo D, Lacadie C, Belfort-Deaguiar R, Groskreutz D, Hamza M, Dai F, Scheinost D, Sinha R, Todd Constable R, Sherwin R, Hwang JJ. J Clin Endocrinol Metab. 2020 Jan 1. PMID: 31511876.", + "In a Free-Living Setting, Obesity Is Associated With Greater Food Intake in Response to a Similar Premeal Glucose Nadir. Kim J, Lam W, Wang Q, Parikh L, Elshafie A, Sanchez-Rangel E, Schmidt C, Li F, Hwang J, Belfort-DeAguiar R. J Clin Endocrinol Metab. 2019 Sep 1. PMID: 31087061.", + "CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation. Esteghamat F, Broughton JS, Smith E, Cardone R, Tyagi T, Guerra M, Szabó A, Ugwu N, Mani MV, Azari B, Kayingo G, Chung S, Fathzadeh M, Weiss E, Bender J, Mane S, Lifton RP, Adeniran A, Nathanson MH, Gorelick FS, Hwa J, Sahin-Tóth M, Belfort-DeAguiar R, Kibbey RG, Mani A. Nat Genet. 2019 Aug; 2019 Jul 29. PMID: 31358993.", + "Food Cues and Obesity: Overpowering Hormones and Energy Balance Regulation. Belfort-DeAguiar R, Seo D. Curr Obes Rep. 2018 Jun. PMID: 29619632.", + "Noradrenergic Activity in the Human Brain: A Mechanism Supporting the Defense Against Hypoglycemia. Belfort-DeAguiar R, Gallezot JD, Hwang JJ, Elshafie A, Yeckel CW, Chan O, Carson RE, Ding YS, Sherwin RS. J Clin Endocrinol Metab. 2018 Jun 1. PMID: 29590401.", + "Humans with obesity have disordered brain responses to food images during physiological hyperglycemia. Belfort-DeAguiar R, Seo D, Lacadie C, Naik S, Schmidt C, Lam W, Hwang J, Constable T, Sinha R, Sherwin RS. Am J Physiol Endocrinol Metab. 2018 May 1; 2018 Jan 30. PMID: 29381374.", + "Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia. Hwang JJ, Parikh L, Lacadie C, Seo D, Lam W, Hamza M, Schmidt C, Dai F, Sejling AS, Belfort-DeAguiar R, Constable RT, Sinha R, Sherwin R. J Clin Invest. 2018 Apr 2; 2018 Mar 5. PMID: 29381484.", + "Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM. Hwang JJ, Jiang L, Hamza M, Sanchez Rangel E, Dai F, Belfort-DeAguiar R, Parikh L, Koo BB, Rothman DL, Mason G, Sherwin RS. JCI Insight. 2017 Oct 19; 2017 Oct 19. PMID: 29046482.", + "Evaluation of the counter-regulatory responses to hypoglycaemia in patients with type 1 diabetes during opiate receptor blockade with naltrexone. Naik S, Belfort-DeAguiar R, Sejling AS, Szepietowska B, Sherwin RS. Diabetes Obes Metab. 2017 May; 2017 Feb 17. PMID: 27987236.", + "The human brain produces fructose from glucose. Hwang JJ, Jiang L, Hamza M, Dai F, Belfort-DeAguiar R, Cline G, Rothman DL, Mason G, Sherwin RS. JCI Insight. 2017 Feb 23; 2017 Feb 23. PMID: 28239653.", + "Food image-induced brain activation is not diminished by insulin infusion. Belfort-DeAguiar R, Seo D, Naik S, Hwang J, Lacadie C, Schmidt C, Constable RT, Sinha R, Sherwin R. Int J Obes (Lond). 2016 Nov; 2016 Aug 29. PMID: 27569684.", + "Inhaled Formoterol Diminishes Insulin-Induced Hypoglycemia in Type 1 Diabetes. Belfort-DeAguiar RD, Naik S, Hwang J, Szepietowska B, Sherwin RS. Diabetes Care. 2015 Sep; 2015 Jul 7. PMID: 26153273.", + "Fructose levels are markedly elevated in cerebrospinal fluid compared to plasma in pregnant women. Hwang JJ, Johnson A, Cline G, Belfort-DeAguiar R, Snegovskikh D, Khokhar B, Han CS, Sherwin RS. PLoS One. 2015; 2015 Jun 2. PMID: 26035307.", + "Functional MRI signal fluctuations: a preclinical biomarker for cognitive impairment in type 2 diabetes? Belfort-Deaguiar R, Constable RT, Sherwin RS. Diabetes. 2014 Feb. PMID: 24464717.", + "Increased brain transport and metabolism of acetate in hypoglycemia unawareness. Gulanski BI, De Feyter HM, Page KA, Belfort-DeAguiar R, Mason GF, Rothman DL, Sherwin RS. J Clin Endocrinol Metab. 2013 Sep; 2013 Jun 24. PMID: 23796565.", + "Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways. Page KA, Chan O, Arora J, Belfort-Deaguiar R, Dzuira J, Roehmholdt B, Cline GW, Naik S, Sinha R, Constable RT, Sherwin RS. JAMA. 2013 Jan 2. PMID: 23280226.", + "Circulating glucose levels modulate neural control of desire for high-calorie foods in humans. Page KA, Seo D, Belfort-DeAguiar R, Lacadie C, Dzuira J, Naik S, Amarnath S, Constable RT, Sherwin RS, Sinha R. J Clin Invest. 2011 Oct; 2011 Sep 19. PMID: 21926468.", + "Fenofibrate reduces systemic inflammation markers independent of its effects on lipid and glucose metabolism in patients with the metabolic syndrome. Belfort R, Berria R, Cornell J, Cusi K. J Clin Endocrinol Metab. 2010 Feb; 2010 Jan 8. PMID: 20061429.", + "Chronic low-dose lipid infusion in healthy patients induces markers of endothelial activation independent of its metabolic effects. Kashyap SR, Belfort R, Cersosimo E, Lee S, Cusi K. J Cardiometab Syndr. 2008 Summer. PMID: 18983329.", + "Pioglitazone treatment increases whole body fat but not total body water in patients with non-alcoholic steatohepatitis. Balas B, Belfort R, Harrison SA, Darland C, Finch J, Schenker S, Gastaldelli A, Cusi K. J Hepatol. 2007 Oct; 2007 May 24. PMID: 17560678.", + "A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, Balas B, Gastaldelli A, Tio F, Pulcini J, Berria R, Ma JZ, Dwivedi S, Havranek R, Fincke C, DeFronzo R, Bannayan GA, Schenker S, Cusi K. N Engl J Med. 2006 Nov 30. PMID: 17135584.", + "Reduction in hematocrit level after pioglitazone treatment is correlated with decreased plasma free testosterone level, not hemodilution, in women with polycystic ovary syndrome. Berria R, Gastaldelli A, Lucidi S, Belfort R, De Filippis E, Easton C, Brytzki R, Cusi K, Jovanovic L, DeFronzo R. Clin Pharmacol Ther. 2006 Aug; 2006 Jun 30. PMID: 16890572.", + "Increased collagen content in insulin-resistant skeletal muscle. Berria R, Wang L, Richardson DK, Finlayson J, Belfort R, Pratipanawatr T, De Filippis EA, Kashyap S, Mandarino LJ. Am J Physiol Endocrinol Metab. 2006 Mar; 2005 Oct 25. PMID: 16249255.", + "Dose-response effect of elevated plasma free fatty acid on insulin signaling. Belfort R, Mandarino L, Kashyap S, Wirfel K, Pratipanawatr T, Berria R, Defronzo RA, Cusi K. Diabetes. 2005 Jun. PMID: 15919784.", + "Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects. Kashyap SR, Roman LJ, Lamont J, Masters BS, Bajaj M, Suraamornkul S, Belfort R, Berria R, Kellogg DL Jr, Liu Y, DeFronzo RA. J Clin Endocrinol Metab. 2005 Feb; 2004 Nov 23. PMID: 15562034.", + "Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects. Christ-Roberts CY, Pratipanawatr T, Pratipanawatr W, Berria R, Belfort R, Kashyap S, Mandarino LJ. Metabolism. 2004 Sep. PMID: 15334390.", + "Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes. Kashyap SR, Belfort R, Berria R, Suraamornkul S, Pratipranawatr T, Finlayson J, Barrentine A, Bajaj M, Mandarino L, DeFronzo R, Cusi K. Am J Physiol Endocrinol Metab. 2004 Sep; 2004 May 4. PMID: 15126243.", + "Increased insulin receptor signaling and glycogen synthase activity contribute to the synergistic effect of exercise on insulin action. Christ-Roberts CY, Pratipanawatr T, Pratipanawatr W, Berria R, Belfort R, Mandarino LJ. J Appl Physiol (1985). 2003 Dec; 2003 Aug 8. PMID: 12909611.", + "A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. Kashyap S, Belfort R, Gastaldelli A, Pratipanawatr T, Berria R, Pratipanawatr W, Bajaj M, Mandarino L, DeFronzo R, Cusi K. Diabetes. 2003 Oct. PMID: 14514628.", + "Free fatty acid-induced peripheral insulin resistance augments splanchnic glucose uptake in healthy humans. Bajaj M, Berria R, Pratipanawatr T, Kashyap S, Pratipanawatr W, Belfort R, Cusi K, Mandarino L, DeFronzo RA. Am J Physiol Endocrinol Metab. 2002 Aug. PMID: 12110541.", + "Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects. Pratipanawatr T, Pratipanawatr W, Rosen C, Berria R, Bajaj M, Cusi K, Mandarino L, Kashyap S, Belfort R, DeFronzo RA. Am J Physiol Endocrinol Metab. 2002 Jun. PMID: 12006367.", + "Maps & Directions", + "1 Event you could attend in November 2025 Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Bennett Laboratory", + "lab_url": "https://medicine.yale.edu/lab/bennett/", + "research_bio": "INFORMATION FOR The focus of the research in this laboratory is to understand how protein tyrosine phosphatases function in the control of normal cellular physiology. The ultimate goal of our research on protein tyrosine phosphatases is to establish whether these enzymes participate in disease processes such as cancer, diabetes and muscular dystrophy. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/bennett/publications/", + "publications": [ + "Yale School of Medicine /", + "Pharmacology /", + "Current Research", + "Publications", + "People", + "Contact", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Current Research", + "Publications", + "People", + "Contact", + "", + "", + "", + "", + "", + "", + "SHP2 genetic variants in NSML-associated RASopathies disrupt the PZR-IRX transcription factor signaling axis. Perla S, Stiegler AL, Yi JS, Enyenihi L, Zhang L, Riaz M, An E, Qyang Y, Boggon TJ, Bennett AM. Proc Natl Acad Sci U S A. 2025 Sep 2; 2025 Aug 25. PMID: 40854126.", + "Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase. Skeens E, Maschietto F, Manjula R, Shillingford S, Murphy J, Lolis EJ, Batista VS, Bennett AM, Lisi GP. Nat Commun. 2025 Jul 31; 2025 Jul 31. PMID: 40745179.", + "MAP kinase phosphatases in metabolic diseases. Hota A, Bennett AM. Trends Endocrinol Metab. 2025 Jun 23; 2025 Jun 23. PMID: 40555575.", + "MAP Kinase Phosphatase-5 Deficiency Improves Endurance Exercise Capacity. Perales JA, Lawan A, Bajpeyi S, Han SM, Bennett AM, Min K. Cells. 2025 Mar 11; 2025 Mar 11. PMID: 40136658.", + "Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT. Ong Q, Lim LTR, Goh C, Liao Y, Chan SE, Lim CJY, Kam V, Yap J, Tseng T, Desrouleaux R, Wang LC, Ler SG, Lim SL, Kim SY, Sobota RM, Bennett AM, Han W, Yang X. Nat Chem Biol. 2025 Feb; 2024 Nov 14. PMID: 39543398.", + "Protein Tyrosine Phosphatases in Metabolism: A New Frontier for Therapeutics. Bennett AM, Tiganis T. Annu Rev Physiol. 2025 Feb; 2025 Feb 3. PMID: 39531392.", + "Mitogen-Activated Protein Kinase Phosphatase-5 is Required for TGF-β Signaling Through a JNK-Dependent Pathway. Dorry S, Perla S, Bennett AM. Mol Cell Biol. 2025 Jan; 2024 Nov 28. PMID: 39607740.", + "Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase. Skeens E, Maschietto F, Manjula R, Shillingford S, Lolis EJ, Batista VS, Bennett AM, Lisi GP. bioRxiv. 2024 Sep 5; 2024 Sep 5. PMID: 39282375.", + "miR-33 deletion in hepatocytes attenuates MASLD-MASH-HCC progression. Fernández-Tussy P, Cardelo MP, Zhang H, Sun J, Price NL, Boutagy NE, Goedeke L, Cadena-Sandoval M, Xirouchaki CE, Brown W, Yang X, Pastor-Rojo O, Haeusler RA, Bennett AM, Tiganis T, Suárez Y, Fernández-Hernando C. JCI Insight. 2024 Aug 27; 2024 Aug 27. PMID: 39190492.", + "MAPK Phosphatase-5 is required for TGF-β signaling through a JNK-dependent pathway. Dorry S, Perla S, Bennett AM. bioRxiv. 2024 Jun 27; 2024 Jun 27. PMID: 38979264.", + "Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α. Liu B, Xie D, Huang X, Jin S, Dai Y, Sun X, Li D, Bennett AM, Diano S, Huang Y. Diabetologia. 2024 Apr; 2024 Jan 13. PMID: 38216792.", + "The 8th International RASopathies Symposium: Expanding research and care practice through global collaboration and advocacy. Pierpont EI, Bennett AM, Schoyer L, Stronach B, Anschutz A, Borrie SC, Briggs B, Burkitt-Wright E, Castel P, Cirstea IC, Draaisma F, Ellis M, Fear VS, Frone MN, Flex E, Gelb BD, Green T, Gripp KW, Khoshkhoo S, Kieran MW, Kleemann K, Klein-Tasman BP, Kontaridis MI, Kruszka P, Leoni C, Liu CZ, Merchant N, Magoulas PL, Moertel C, Prada CE, Rauen KA, Roelofs R, Rossignol R, Sevilla C, Sevilla G, Sheedy R, Stieglitz E, Sun D, Tiemens D, White F, Wingbermühle E, Wolf C, Zenker M, Andelfinger G. Am J Med Genet A. 2024 Apr; 2023 Nov 15. PMID: 37969032.", + "MAPK phosphatase 1 inhibition of p38α within lung myofibroblasts is essential for spontaneous fibrosis resolution. Fortier SM, Walker NM, Penke LR, Baas JD, Shen Q, Speth JM, Huang SK, Zemans RL, Bennett AM, Peters-Golden M. J Clin Invest. 2024 Mar 21; 2024 Mar 21. PMID: 38512415.", + "Identification of Protein Tyrosine Phosphatase (PTP) Substrates. Perla S, Qiu B, Dorry S, Yi JS, Bennett AM. Methods Mol Biol. 2024. PMID: 38147212.", + "An Assessment of the Therapeutic Landscape for the Treatment of Heart Disease in the RASopathies. Yi JS, Perla S, Bennett AM. Cardiovasc Drugs Ther. 2023 Dec; 2022 Feb 14. PMID: 35156148.", + "MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention. Qiu B, Lawan A, Xirouchaki CE, Yi JS, Robert M, Zhang L, Brown W, Fernández-Hernando C, Yang X, Tiganis T, Bennett AM. Nat Commun. 2023 Sep 5; 2023 Sep 5. PMID: 37669951.", + "MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention. Qiu B, Lawan A, Xirouchaki CE, Yi JS, Robert M, Zhang L, Brown W, Fernández-Hernando C, Yang X, Tiganis T, Bennett AM. bioRxiv. 2023 Jul 11; 2023 Jul 11. PMID: 37502892.", + "Teaching an old dog new tricks: A new tool for protein tyrosine phosphatase substrate discovery. Bennett AM. J Biol Chem. 2023 May; 2023 Apr 18. PMID: 37080392.", + "SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung Fibroblasts. Karampitsakos T, Galaris A, Barbayianni I, DeIuliis G, Ahangari F, Sampsonas F, Sotiropoulou V, Aidinis V, Bennett AM, Herazo-Maya JD, Xylourgidis N, Bakakos P, Bouros D, Kaminski N, Tzouvelekis A. Diagnostics (Basel). 2023 Mar 18; 2023 Mar 18. PMID: 36980473.", + "Hepatocyte-specific miR-33 deletion attenuates NAFLD-NASH-HCC progression. Fernández-Tussy P, Sun J, Cardelo MP, Price NL, Goedeke L, Xirouchaki CE, Yang X, Pastor-Rojo O, Bennett AM, Tiganis T, Suárez Y, Fernández-Hernando C. bioRxiv. 2023 Jan 20; 2023 Jan 20. PMID: 36711578.", + "Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable? Shillingford SR, Bennett AM. Annu Rev Pharmacol Toxicol. 2023 Jan 20. PMID: 36662585.", + "Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors. Gannam ZTK, Jamali H, Kweon OS, Herrington J, Shillingford SR, Papini C, Gentzel E, Lolis E, Bennett AM, Ellman JA, Anderson KS. Eur J Med Chem. 2022 Dec 5; 2022 Sep 2. PMID: 36116232.", + "A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding. Shillingford S, Zhang L, Surovtseva Y, Dorry S, Lolis E, Bennett AM. J Biol Chem. 2022 Dec; 2022 Oct 19. PMID: 36272649.", + "Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines. Yi JS, Perla S, Huang Y, Mizuno K, Giordano FJ, Vinks AA, Bennett AM. Cardiovasc Drugs Ther. 2022 Aug; 2021 Mar 10. PMID: 33689087.", + "The seventh international RASopathies symposium: Pathways to a cure-expanding knowledge, enhancing research, and therapeutic discovery. Kontaridis MI, Roberts AE, Schill L, Schoyer L, Stronach B, Andelfinger G, Aoki Y, Axelrad ME, Bakker A, Bennett AM, Broniscer A, Castel P, Chang CA, Cyganek L, Das TK, den Hertog J, Galperin E, Garg S, Gelb BD, Gordon K, Green T, Gripp KW, Itkin M, Kiuru M, Korf BR, Livingstone JR, López-Juárez A, Magoulas PL, Mansour S, Milner T, Parker E, Pierpont EI, Plouffe K, Rauen KA, Shankar SP, Smith SB, Stevenson DA, Tartaglia M, Van R, Wagner ME, Ware SM, Zenker M. Am J Med Genet A. 2022 Jun; 2022 Mar 9. PMID: 35266292.", + "MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis. Zhong C, Min K, Zhao Z, Zhang C, Gao E, Huang Y, Zhang X, Baldini M, Roy R, Yang X, Koch WJ, Bennett AM, Yu J. Front Immunol. 2021; 2021 Dec 21. PMID: 34992607.", + "An allosteric site on MKP5 reveals a strategy for small-molecule inhibition. Gannam ZTK, Min K, Shillingford SR, Zhang L, Herrington J, Abriola L, Gareiss PC, Pantouris G, Tzouvelekis A, Kaminski N, Zhang X, Yu J, Jamali H, Ellman JA, Lolis E, Anderson KS, Bennett AM. Sci Signal. 2020 Aug 25; 2020 Aug 25. PMID: 32843541.", + "Tyrosyl phosphorylation of PZR promotes hypertrophic cardiomyopathy in PTPN11-associated Noonan syndrome with multiple lentigines. Yi JS, Perla S, Enyenihi L, Bennett AM. JCI Insight. 2020 Aug 6; 2020 Aug 6. PMID: 32584792.", + "The sixth international RASopathies symposium: Precision medicine-From promise to practice. Gripp KW, Schill L, Schoyer L, Stronach B, Bennett AM, Blaser S, Brown A, Burdine R, Burkitt-Wright E, Castel P, Darilek S, Dias A, Dyer T, Ellis M, Erickson G, Gelb BD, Green T, Gross A, Ho A, Holder JL Jr, Inoue SI, Jelin AC, Kennedy A, Klein R, Kontaridis MI, Magoulas P, McConnell DB, McCormick F, Neel BG, Prada CE, Rauen KA, Roberts A, Rodriguez-Viciana P, Rosen N, Rumbaugh G, Sablina A, Solman M, Tartaglia M, Thomas A, Timmer WC, Venkatachalam K, Walsh KS, Wolters PL, Yi JS, Zenker M, Ratner N. Am J Med Genet A. 2020 Mar; 2019 Dec 11. PMID: 31825160.", + "Improving Obesity and Insulin Resistance by Targeting Skeletal Muscle MKP-1. Bennett AM, Lawan A. J Cell Signal. 2020. PMID: 33179019.", + "O-GlcNAc transferase suppresses necroptosis and liver fibrosis. Zhang B, Li MD, Yin R, Liu Y, Yang Y, Mitchell-Richards KA, Nam JH, Li R, Wang L, Iwakiri Y, Chung D, Robert ME, Ehrlich BE, Bennett AM, Yu J, Nathanson MH, Yang X. JCI Insight. 2019 Nov 1; 2019 Nov 1. PMID: 31672932.", + "Role of dual-specificity protein phosphatase DUSP10/MKP-5 in pulmonary fibrosis. Xylourgidis N, Min K, Ahangari F, Yu G, Herazo-Maya JD, Karampitsakos T, Aidinis V, Binzenhöfer L, Bouros D, Bennett AM, Kaminski N, Tzouvelekis A. Am J Physiol Lung Cell Mol Physiol. 2019 Nov 1; 2019 Sep 4. PMID: 31483681.", + "Noonan Syndrome-Associated SHP2 Dephosphorylates GluN2B to Regulate NMDA Receptor Function. Levy AD, Xiao X, Shaw JE, Sudarsana Devi SP, Katrancha SM, Bennett AM, Greer CA, Howe JR, Machida K, Koleske AJ. Cell Rep. 2018 Aug 7. PMID: 30089263.", + "DUSPs, twists and turns in the Journey to Vascular Inflammation. Bennett AM. FEBS J. 2018 May; 2018 Apr 22. PMID: 29682902.", + "Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance. Lawan A, Min K, Zhang L, Canfran-Duque A, Jurczak MJ, Camporez JPG, Nie Y, Gavin TP, Shulman GI, Fernandez-Hernando C, Bennett AM. Diabetes. 2018 Apr; 2018 Jan 9. PMID: 29317435.", + "Mitogen-Activated Protein Kinase Regulation in Hepatic Metabolism. Lawan A, Bennett AM. Trends Endocrinol Metab. 2017 Dec; 2017 Nov 8. PMID: 29128158.", + "Loss of MKP-5 promotes myofiber survival by activating STAT3/Bcl-2 signaling during regenerative myogenesis. Min K, Lawan A, Bennett AM. Skelet Muscle. 2017 Oct 18; 2017 Oct 18. PMID: 29047406.", + "Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation. Ruan HB, Ma Y, Torres S, Zhang B, Feriod C, Heck RM, Qian K, Fu M, Li X, Nathanson MH, Bennett AM, Nie Y, Ehrlich BE, Yang X. Genes Dev. 2017 Aug 15; 2017 Sep 13. PMID: 28903979.", + "A Phosphoproteomic Screen Identifies a Guanine Nucleotide Exchange Factor for Rab3A Protein as a Mitogen-activated Protein (MAP) Kinase Phosphatase-5-regulated MAP Kinase Target in Interleukin 6 (IL-6) Secretion and Myogenesis. Lee H, Min K, Yi JS, Shi H, Chang W, Jackson L, Bennett AM. J Biol Chem. 2017 Mar 3; 2017 Jan 17. PMID: 28096466.", + "SH2 Domain-Containing Phosphatase-2 Is a Novel Antifibrotic Regulator in Pulmonary Fibrosis. Tzouvelekis A, Yu G, Lino Cardenas CL, Herazo-Maya JD, Wang R, Woolard T, Zhang Y, Sakamoto K, Lee H, Yi JS, DeIuliis G, Xylourgidis N, Ahangari F, Lee PJ, Aidinis V, Herzog EL, Homer R, Bennett AM, Kaminski N. Am J Respir Crit Care Med. 2017 Feb 15. PMID: 27736153.", + "Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver. Feriod CN, Oliveira AG, Guerra MT, Nguyen L, Richards KM, Jurczak MJ, Ruan HB, Camporez JP, Yang X, Shulman GI, Bennett AM, Nathanson MH, Ehrlich BE. Hepatol Commun. 2017 Feb; 2016 Nov 11. PMID: 28966992.", + "Low-dose dasatinib rescues cardiac function in Noonan syndrome. Yi JS, Huang Y, Kwaczala AT, Kuo IY, Ehrlich BE, Campbell SG, Giordano FJ, Bennett AM. JCI Insight. 2016 Dec 8; 2016 Dec 8. PMID: 27942593.", + "Mice lacking MKP-1 and MKP-5 Reveal Hierarchical Regulation of Regenerative Myogenesis. Shi H, Gatzke F, Molle JM, Lee HB, Helm ET, Oldham JJ, Zhang L, Gerrard DE, Bennett AM. J Stem Cell Regen Biol. 2015 Nov 12. PMID: 27064463.", + "Identification of receptor protein tyrosine phosphatases (RPTPs) as regulators of receptor tyrosine kinases (RTKs) using an RPTP siRNA-RTK substrate screen. Lee H, Bennett AM. Methods Mol Biol. 2015. PMID: 25319894.", + "Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis. Lawan A, Zhang L, Gatzke F, Min K, Jurczak MJ, Al-Mutairi M, Richter P, Camporez JP, Couvillon A, Pesta D, Roth Flach RJ, Shulman GI, Bennett AM. Mol Cell Biol. 2015 Jan; 2014 Oct 13. PMID: 25312648.", + "Mining the function of protein tyrosine phosphatases in health and disease. Lee H, Yi JS, Lawan A, Min K, Bennett AM. Semin Cell Dev Biol. 2015 Jan; 2014 Sep 26. PMID: 25263013.", + "Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II. Feriod CN, Nguyen L, Jurczak MJ, Kruglov EA, Nathanson MH, Shulman GI, Bennett AM, Ehrlich BE. Am J Physiol Endocrinol Metab. 2014 Dec 1; 2014 Oct 14. PMID: 25315698.", + "PZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice. Paardekooper Overman J, Yi JS, Bonetti M, Soulsby M, Preisinger C, Stokes MP, Hui L, Silva JC, Overvoorde J, Giansanti P, Heck AJ, Kontaridis MI, den Hertog J, Bennett AM. Mol Cell Biol. 2014 Aug; 2014 May 27. PMID: 24865967.", + "The imprinted H19 lncRNA antagonizes let-7 microRNAs. Kallen AN, Zhou XB, Xu J, Qiao C, Ma J, Yan L, Lu L, Liu C, Yi JS, Zhang H, Min W, Bennett AM, Gregory RI, Ding Y, Huang Y. Mol Cell. 2013 Oct 10; 2013 Sep 19. PMID: 24055342.", + "Improved regenerative myogenesis and muscular dystrophy in mice lacking Mkp5. Shi H, Verma M, Zhang L, Dong C, Flavell RA, Bennett AM. J Clin Invest. 2013 May; 2013 Apr 1. PMID: 23543058.", + "Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration. Lee H, Bennett AM. Mol Cell Biol. 2013 Apr; 2013 Jan 28. PMID: 23358419.", + "Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling. Mercan F, Lee H, Kolli S, Bennett AM. Mol Cell Biol. 2013 Jan; 2012 Nov 5. PMID: 23129808.", + "Diversity and specificity of the mitogen-activated protein kinase phosphatase-1 functions. Lawan A, Shi H, Gatzke F, Bennett AM. Cell Mol Life Sci. 2013 Jan; 2012 Jun 14. PMID: 22695679.", + "The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation. Timmerman I, Hoogenboezem M, Bennett AM, Geerts D, Hordijk PL, van Buul JD. Mol Biol Cell. 2012 Nov; 2012 Sep 5. PMID: 22956765.", + "O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability. Ruan HB, Han X, Li MD, Singh JP, Qian K, Azarhoush S, Zhao L, Bennett AM, Samuel VT, Wu J, Yates JR 3rd, Yang X. Cell Metab. 2012 Aug 8. PMID: 22883232.", + "Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Diano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser JL, Belsham DD, Sarruf DA, Schwartz MW, Bennett AM, Shanabrough M, Mobbs CV, Yang X, Gao XB, Horvath TL. Nat Med. 2011 Aug 28; 2011 Aug 28. PMID: 21873987.", + "Loss of mitogen-activated protein kinase phosphatase-1 protects from hepatic steatosis by repression of cell death-inducing DNA fragmentation factor A (DFFA)-like effector C (CIDEC)/fat-specific protein 27. Flach RJ, Qin H, Zhang L, Bennett AM. J Biol Chem. 2011 Jun 24; 2011 Apr 26. PMID: 21521693.", + "Mitogen-activated protein kinase phosphatase-1 - a potential therapeutic target in metabolic disease. Roth Flach RJ, Bennett AM. Expert Opin Ther Targets. 2010 Dec. PMID: 21058921.", + "The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching. Jeanneteau F, Deinhardt K, Miyoshi G, Bennett AM, Chao MV. Nat Neurosci. 2010 Nov; 2010 Oct 10. PMID: 20935641.", + "MAP kinase phosphatase-1 deficiency impairs skeletal muscle regeneration and exacerbates muscular dystrophy. Shi H, Boadu E, Mercan F, Le AM, Flach RJ, Zhang L, Tyner KJ, Olwin BB, Bennett AM. FASEB J. 2010 Aug; 2010 Apr 6. PMID: 20371627.", + "Analysis of protein tyrosine phosphatases and substrates. Mercan F, Bennett AM. Curr Protoc Mol Biol. 2010 Jul. PMID: 20583096.", + "MAP kinase phosphatase-1--a new player at the nexus between sarcopenia and metabolic disease. Flach RJ, Bennett AM. Aging (Albany NY). 2010 Apr 6; 2010 Apr 6. PMID: 20375469.", + "MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice. Roth RJ, Le AM, Zhang L, Kahn M, Samuel VT, Shulman GI, Bennett AM. J Clin Invest. 2009 Dec; 2009 Nov 16. PMID: 19920356.", + "Physiological signaling specificity by protein tyrosine phosphatases. Soulsby M, Bennett AM. Physiology (Bethesda). 2009 Oct. PMID: 19815854.", + "Role of MKP-1 in osteoclasts and bone homeostasis. Carlson J, Cui W, Zhang Q, Xu X, Mercan F, Bennett AM, Vignery A. Am J Pathol. 2009 Oct; 2009 Sep 17. PMID: 19762714.", + "JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1. Yu L, Min W, He Y, Qin L, Zhang H, Bennett AM, Chen H. J Biol Chem. 2009 May 15; 2009 Mar 13. PMID: 19287004.", + "Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPalpha and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation. Eminaga S, Bennett AM. J Biol Chem. 2008 May 30; 2008 Mar 31. PMID: 18378677.", + "A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factor. Ha CH, Bennett AM, Jin ZG. J Biol Chem. 2008 Mar 14; 2008 Jan 7. PMID: 18180305.", + "c-Met must translocate to the nucleus to initiate calcium signals. Gomes DA, Rodrigues MA, Leite MF, Gomez MV, Varnai P, Balla T, Bennett AM, Nathanson MH. J Biol Chem. 2008 Feb 15; 2007 Dec 11. PMID: 18073207.", + "Nucleoplasmic calcium is required for cell proliferation. Rodrigues MA, Gomes DA, Leite MF, Grant W, Zhang L, Lam W, Cheng YC, Bennett AM, Nathanson MH. J Biol Chem. 2007 Jun 8; 2007 Apr 9. PMID: 17420246.", + "SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway. Zito CI, Qin H, Blenis J, Bennett AM. J Biol Chem. 2007 Mar 9; 2007 Jan 17. PMID: 17229738.", + "Protein tyrosine phosphatase function: the substrate perspective. Tiganis T, Bennett AM. Biochem J. 2007 Feb 15. PMID: 17238862.", + "SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth. Fornaro M, Burch PM, Yang W, Zhang L, Hamilton CE, Kim JH, Neel BG, Bennett AM. J Cell Biol. 2006 Oct 9; 2006 Oct 2. PMID: 17015617.", + "Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity. Wu JJ, Roth RJ, Anderson EJ, Hong EG, Lee MK, Choi CS, Neufer PD, Shulman GI, Kim JK, Bennett AM. Cell Metab. 2006 Jul. PMID: 16814733.", + "Calcium signaling in the nucleus. Gomes DA, Leite MF, Bennett AM, Nathanson MH. Can J Physiol Pharmacol. 2006 Mar-Apr. PMID: 16902580.", + "Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Chi H, Barry SP, Roth RJ, Wu JJ, Jones EA, Bennett AM, Flavell RA. Proc Natl Acad Sci U S A. 2006 Feb 14; 2006 Feb 6. PMID: 16461893.", + "Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling. Uhlén P, Burch PM, Zito CI, Estrada M, Ehrlich BE, Bennett AM. Proc Natl Acad Sci U S A. 2006 Feb 14; 2006 Feb 3. PMID: 16461457.", + "Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver. Park SY, Cho YR, Finck BN, Kim HJ, Higashimori T, Hong EG, Lee MK, Danton C, Deshmukh S, Cline GW, Wu JJ, Bennett AM, Rothermel B, Kalinowski A, Russell KS, Kim YB, Kelly DP, Kim JK. Diabetes. 2005 Sep. PMID: 16123338.", + "The noncatalytic amino terminus of mitogen-activated protein kinase phosphatase 1 directs nuclear targeting and serum response element transcriptional regulation. Wu JJ, Zhang L, Bennett AM. Mol Cell Biol. 2005 Jun. PMID: 15899879.", + "Essential role for mitogen-activated protein (MAP) kinase phosphatase-1 in stress-responsive MAP kinase and cell survival signaling. Wu JJ, Bennett AM. J Biol Chem. 2005 Apr 22; 2005 Feb 17. PMID: 15722358.", + "Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. Chauvet V, Tian X, Husson H, Grimm DH, Wang T, Hiesberger T, Igarashi P, Bennett AM, Ibraghimov-Beskrovnaya O, Somlo S, Caplan MJ. J Clin Invest. 2004 Nov. PMID: 15545994.", + "The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. Kolli S, Zito CI, Mossink MH, Wiemer EA, Bennett AM. J Biol Chem. 2004 Jul 9; 2004 May 7. PMID: 15133037.", + "SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway. Kontaridis MI, Eminaga S, Fornaro M, Zito CI, Sordella R, Settleman J, Bennett AM. Mol Cell Biol. 2004 Jun. PMID: 15169898.", + "SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis. Ivins Zito C, Kontaridis MI, Fornaro M, Feng GS, Bennett AM. J Cell Physiol. 2004 May. PMID: 15040005.", + "Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium. Pusl T, Wu JJ, Zimmerman TL, Zhang L, Ehrlich BE, Berchtold MW, Hoek JB, Karpen SJ, Nathanson MH, Bennett AM. J Biol Chem. 2002 Jul 26; 2002 Apr 23. PMID: 11971908.", + "Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts. Kontaridis MI, Liu X, Zhang L, Bennett AM. Mol Cell Biol. 2002 Jun. PMID: 11997521.", + "Sterling Hall of Medicine 333 Cedar Street New Haven, CT 06520-8066", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Bergwitz Lab", + "lab_url": "https://medicine.yale.edu/lab/bergwitz/", + "research_bio": "INFORMATION FOR Our research focuses on inborn errors of phosphate metabolism and the endocrine regulation of phosphate homeostasis with emphasis on the metabolic and homeostatic effects of phosphate. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/bergwitz/publications/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Endocrinology /", + "Projects", + "Activities Conferences", + "Conferences", + "Lab Members Alumni", + "Alumni", + "Publications", + "Opportunities", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Projects", + "Lab Members", + "Publications", + "Opportunities", + "Activities", + "", + "", + "", + "", + "", + "", + "Treatment of Extraosseous Giant Cell Tumor of Bone and Calcitriol-Mediated Hypercalcemia With Denosumab in Paget Disease. Magvanjav O, Bergwitz C. JCEM Case Rep. 2025 Apr; 2025 Mar 19. PMID: 40110572.", + "Phenotypic variability in phosphate transport disorders highlights need for individualized treatment strategies. Zhu Z, Bergwitz C. Kidney Int. 2025 Jan. PMID: 39746740.", + "Both enantiomers of β-aminoisobutyric acid BAIBA regulate Fgf23 via MRGPRD receptor by activating distinct signaling pathways in osteocytes. Sakamoto E, Kitase Y, Fitt AJ, Zhu Z, Awad K, Brotto M, White KE, Welc SS, Bergwitz C, Bonewald LF. Cell Rep. 2024 Jul 23; 2024 Jun 25. PMID: 38935499.", + "Erratum to \"An update on clinical presentation and responses to therapy of patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH).\" Kidney International 2023;105:1058-1076. Zhu Z, Bo-Ran Ho B, Chen A, Amrhein J, Apetrei A, Carpenter TO, Lazaretti-Castro M, Colazo JM, McCrystal Dahir K, Geßner M, Gurevich E, Heier CA, Simmons JH, Hunley TE, Hoppe B, Jacobsen C, Kouri A, Ma N, Majumdar S, Molin A, Nokoff N, Ott SM, Peña HG, Santos F, Tebben P, Topor LS, Deng Y, Bergwitz C. Kidney Int. 2024 Jul. PMID: 38906648.", + "An update on clinical presentation and responses to therapy of patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH). Zhu Z, Bo-Ran Ho B, Chen A, Amrhein J, Apetrei A, Carpenter TO, Lazaretti-Castro M, Colazo JM, McCrystal Dahir K, Geßner M, Gurevich E, Heier CA, Simmons JH, Hunley TE, Hoppe B, Jacobsen C, Kouri A, Ma N, Majumdar S, Molin A, Nokoff N, Ott SM, Peña HG, Santos F, Tebben P, Topor LS, Deng Y, Bergwitz C. Kidney Int. 2024 May; 2024 Feb 15. PMID: 38364990.", + "Hereditary Hypophosphatemic Rickets with Hypercalciuria Presenting with Enthesopathy, Renal Cysts, and High Serum c-Terminal FGF23: Single-Center Experience and Systematic Review. Dodamani MH, Memon SS, Karlekar M, Lila AR, Khan M, Sarathi V, Arya S, Jamale T, Thakare S, Patil VA, Shah NS, Bergwitz C, Bandgar TR. Calcif Tissue Int. 2024 Feb; 2023 Nov 19. PMID: 37981601.", + "Multifocal heterotopic ossification in a man with germline variants of LIM Mineralization Protein-1 (LMP-1). Sangadala S, Shore EM, Xu M, Bergwitz C, Lozano-Calderon SA, Lin AE, Boden SD, Kaplan FS. Am J Med Genet A. 2023 Aug; 2023 May 23. PMID: 37218523.", + "Phosphorus bioaccessibility measured in four amino acid-based formulas using in-vitro batch digestion translates well into phosphorus bioavailability in mice. Chande S, Dijk F, Fetene J, Yannicelli S, Carpenter TO, van Helvoort A, Bergwitz C. Nutrition. 2021 Sep; 2021 Apr 28. PMID: 34111672.", + "FGF23 signalling and physiology. Ho BB, Bergwitz C. J Mol Endocrinol. 2021 Feb. PMID: 33338030.", + "Different elemental infant formulas show equivalent phosphorus and calcium bioavailability in healthy volunteers. Bergwitz C, Eussen SRBM, Janssens PLHR, Visser M, Carpenter TO, van Helvoort A. Nutr Res. 2021 Jan; 2020 Nov 18. PMID: 33450668.", + "Targeted FGFR Blockade for the Treatment of Tumor-Induced Osteomalacia. Hartley IR, Miller CB, Papadakis GZ, Bergwitz C, Del Rivero J, Blau JE, Florenzano P, Berglund JA, Tassone J, Roszko KL, Moran S, Gafni RI, Isaacs R, Collins MT. N Engl J Med. 2020 Oct 1; 2020 Sep 9. PMID: 32905668.", + "Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging. Serna J, Bergwitz C. Nutrients. 2020 Sep 30; 2020 Sep 30. PMID: 33007883.", + "Description of a novel SLC34A3.c.671delT mutation causing hereditary hypophosphatemic rickets with hypercalciuria in two adolescent boys and response to recombinant human growth hormone. Dreimane D, Chen A, Bergwitz C. Ther Adv Musculoskelet Dis. 2020; 2020 Sep 12. PMID: 32963591.", + "Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival. Chande S, Caballero D, Ho BB, Fetene J, Serna J, Pesta D, Nasiri A, Jurczak M, Chavkin NW, Hernando N, Giachelli CM, Wagner CA, Zeiss C, Shulman GI, Bergwitz C. Sci Rep. 2020 Feb 20; 2020 Feb 20. PMID: 32080237.", + "Transgenic mouse model for conditional expression of influenza hemagglutinin-tagged human SLC20A1/PIT1. Chande S, Ho B, Fetene J, Bergwitz C. PLoS One. 2019; 2019 Oct 15. PMID: 31613887.", + "Description of 5 Novel SLC34A3/NPT2c Mutations Causing Hereditary Hypophosphatemic Rickets With Hypercalciuria. Chen A, Ro H, Mundra VRR, Joseph K, Brenner D, Carpenter TO, Rizk DV, Bergwitz C. Kidney Int Rep. 2019 Aug; 2019 May 17. PMID: 31440709.", + "Endocrine regulation of MFS2 by branchless controls phosphate excretion and stone formation in Drosophila renal tubules. Rose E, Lee D, Xiao E, Zhao W, Wee M, Cohen J, Bergwitz C. Sci Rep. 2019 Jun 19; 2019 Jun 19. PMID: 31217461.", + "Hereditary hypophosphatemic rickets with hypercalciuria: pathophysiology, clinical presentation, diagnosis and therapy. Bergwitz C, Miyamoto KI. Pflugers Arch. 2019 Jan; 2018 Aug 14. PMID: 30109410.", + "Role of phosphate sensing in bone and mineral metabolism. Chande S, Bergwitz C. Nat Rev Endocrinol. 2018 Nov. PMID: 30218014.", + "Intraperitoneal pyrophosphate treatment reduces renal calcifications in Npt2a null mice. Caballero D, Li Y, Fetene J, Ponsetto J, Chen A, Zhu C, Braddock DT, Bergwitz C. PLoS One. 2017; 2017 Jul 13. PMID: 28704395.", + "Response of Npt2a knockout mice to dietary calcium and phosphorus. Li Y, Caballero D, Ponsetto J, Chen A, Zhu C, Guo J, Demay M, Jüppner H, Bergwitz C. PLoS One. 2017; 2017 Apr 27. PMID: 28448530.", + "Impaired urinary osteopontin excretion in Npt2a-/- mice. Caballero D, Li Y, Ponsetto J, Zhu C, Bergwitz C. Am J Physiol Renal Physiol. 2017 Jan 1; 2016 Oct 26. PMID: 27784695.", + "Hypophosphatemia promotes lower rates of muscle ATP synthesis. Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI. FASEB J. 2016 Oct; 2016 Jun 23. PMID: 27338702.", + "Mutations in SLC34A3/NPT2c are associated with kidney stones and nephrocalcinosis. Dasgupta D, Wee MJ, Reyes M, Li Y, Simm PJ, Sharma A, Schlingmann KP, Janner M, Biggin A, Lazier J, Gessner M, Chrysis D, Tuchman S, Baluarte HJ, Levine MA, Tiosano D, Insogna K, Hanley DA, Carpenter TO, Ichikawa S, Hoppe B, Konrad M, Sävendahl L, Munns CF, Lee H, Jüppner H, Bergwitz C. J Am Soc Nephrol. 2014 Oct; 2014 Apr 3. PMID: 24700880.", + "Genetic determinants of phosphate response in Drosophila. Bergwitz C, Wee MJ, Sinha S, Huang J, DeRobertis C, Mensah LB, Cohen J, Friedman A, Kulkarni M, Hu Y, Vinayagam A, Schnall-Levin M, Berger B, Perkins LA, Mohr SE, Perrimon N. PLoS One. 2013; 2013 Mar 8. PMID: 23520455.", + "Fanconi-Bickel syndrome and autosomal recessive proximal tubulopathy with hypercalciuria (ARPTH) are allelic variants caused by GLUT2 mutations. Mannstadt M, Magen D, Segawa H, Stanley T, Sharma A, Sasaki S, Bergwitz C, Mounien L, Boepple P, Thorens B, Zelikovic I, Jüppner H. J Clin Endocrinol Metab. 2012 Oct; 2012 Aug 3. PMID: 22865906.", + "Dietary phosphate modifies lifespan in Drosophila. Bergwitz C. Nephrol Dial Transplant. 2012 Sep. PMID: 22942172.", + "Novel NaPi-IIc mutations causing HHRH and idiopathic hypercalciuria in several unrelated families: long-term follow-up in one kindred. Yu Y, Sanderson SR, Reyes M, Sharma A, Dunbar N, Srivastava T, Jüppner H, Bergwitz C. Bone. 2012 May; 2012 Feb 24. PMID: 22387237.", + "FGF23 and syndromes of abnormal renal phosphate handling. Bergwitz C, Jüppner H. Adv Exp Med Biol. 2012. PMID: 22396161.", + "Roles of major facilitator superfamily transporters in phosphate response in Drosophila. Bergwitz C, Rasmussen MD, DeRobertis C, Wee MJ, Sinha S, Chen HH, Huang J, Perrimon N. PLoS One. 2012; 2012 Feb 16. PMID: 22359624.", + "Case records of the Massachusetts General Hospital. Case 33-2011. A 56-year-old man with hypophosphatemia. Bergwitz C, Collins MT, Kamath RS, Rosenberg AE. N Engl J Med. 2011 Oct 27. PMID: 22029985.", + "An integrative approach to ortholog prediction for disease-focused and other functional studies. Hu Y, Flockhart I, Vinayagam A, Bergwitz C, Berger B, Perrimon N, Mohr SE. BMC Bioinformatics. 2011 Aug 31; 2011 Aug 31. PMID: 21880147.", + "Phosphate sensing. Bergwitz C, Jüppner H. Adv Chronic Kidney Dis. 2011 Mar. PMID: 21406298.", + "Hereditary hypophosphatemic rickets with hypercalciuria and nephrolithiasis-identification of a novel SLC34A3/NaPi-IIc mutation. Phulwani P, Bergwitz C, Jaureguiberry G, Rasoulpour M, Estrada E. Am J Med Genet A. 2011 Mar; 2011 Feb 22. PMID: 21344632.", + "Autoimmune hypocalciuric hypercalcemia unresponsive to glucocorticoid therapy in a patient with blocking autoantibodies against the calcium-sensing receptor. Pallais JC, Kemp EH, Bergwitz C, Kantham L, Slovik DM, Weetman AP, Brown EM. J Clin Endocrinol Metab. 2011 Mar; 2010 Dec 15. PMID: 21159843.", + "Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid hormone analogs. Nagai S, Okazaki M, Segawa H, Bergwitz C, Dean T, Potts JT Jr, Mahon MJ, Gardella TJ, Jüppner H. J Biol Chem. 2011 Jan 14; 2010 Nov 3. PMID: 21047792.", + "Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23. Bergwitz C, Jüppner H. Annu Rev Med. 2010. PMID: 20059333.", + "Defective O-glycosylation due to a novel homozygous S129P mutation is associated with lack of fibroblast growth factor 23 secretion and tumoral calcinosis. Bergwitz C, Banerjee S, Abu-Zahra H, Kaji H, Miyauchi A, Sugimoto T, Jüppner H. J Clin Endocrinol Metab. 2009 Nov; 2009 Oct 16. PMID: 19837926.", + "Hypophosphatemic rickets with hypercalciuria due to mutation in SLC34A3/NaPi-IIc can be masked by vitamin D deficiency and can be associated with renal calcifications. Kremke B, Bergwitz C, Ahrens W, Schütt S, Schumacher M, Wagner V, Holterhus PM, Jüppner H, Hiort O. Exp Clin Endocrinol Diabetes. 2009 Feb; 2008 Jun 3. PMID: 18523928.", + "Disorders of phosphate homeostasis and tissue mineralisation. Bergwitz C, Jüppner H. Endocr Dev. 2009; 2009 Jun 3. PMID: 19494665.", + "NHERF1 mutations and responsiveness of renal parathyroid hormone. Bergwitz C, Bastepe M. N Engl J Med. 2008 Dec 11. PMID: 19073985.", + "Cellular mechanism of decreased bone in Brtl mouse model of OI: imbalance of decreased osteoblast function and increased osteoclasts and their precursors. Uveges TE, Collin-Osdoby P, Cabral WA, Ledgard F, Goldberg L, Bergwitz C, Forlino A, Osdoby P, Gronowicz GA, Marini JC. J Bone Miner Res. 2008 Dec. PMID: 18684089.", + "A patient with hypophosphatemia, a femoral fracture, and recurrent kidney stones: report of a novel mutation in SLC34A3. Page K, Bergwitz C, Jaureguiberry G, Harinarayan CV, Insogna K. Endocr Pract. 2008 Oct. PMID: 18996815.", + "Genetic evidence of serum phosphate-independent functions of FGF-23 on bone. Sitara D, Kim S, Razzaque MS, Bergwitz C, Taguchi T, Schüler C, Erben RG, Lanske B. PLoS Genet. 2008 Aug 8; 2008 Aug 8. PMID: 18688277.", + "A novel missense mutation in SLC34A3 that causes hereditary hypophosphatemic rickets with hypercalciuria in humans identifies threonine 137 as an important determinant of sodium-phosphate cotransport in NaPi-IIc. Jaureguiberry G, Carpenter TO, Forman S, Jüppner H, Bergwitz C. Am J Physiol Renal Physiol. 2008 Aug; 2008 May 14. PMID: 18480181.", + "SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis. Bergwitz C, Roslin NM, Tieder M, Loredo-Osti JC, Bastepe M, Abu-Zahra H, Frappier D, Burkett K, Carpenter TO, Anderson D, Garabedian M, Sermet I, Fujiwara TM, Morgan K, Tenenhouse HS, Juppner H. Am J Hum Genet. 2006 Feb; 2005 Dec 9. PMID: 16358214.", + "Brittle IV mouse model for osteogenesis imperfecta IV demonstrates postpubertal adaptations to improve whole bone strength. Kozloff KM, Carden A, Bergwitz C, Forlino A, Uveges TE, Morris MD, Marini JC, Goldstein SA. J Bone Miner Res. 2004 Apr; 2004 Jan 12. PMID: 15005849.", + "A patient with autoimmune hepatitis type I, Addison's disease, atrophic thyroiditis, atrophic gastritis, exocrine pancreatic insufficiency, and heterozygous alpha1-antitrypsin deficiency. Bergwitz C, Brabant G, Trautwein C, Manns MP. Am J Gastroenterol. 2002 Apr. PMID: 12003388.", + "Cyclic-adenosine 3',5'-monophosphate-stimulated c-fos gene transcription involves distinct calcium pathways in single beta-cells. Schöfl C, Waring M, Bergwitz C, Arseniev L, von zur Muhlen A, Brabant G. Mol Cell Endocrinol. 2002 Jan 15. PMID: 11850128.", + "Identification of novel CBFA1/RUNX2 mutations causing cleidocranial dysplasia. Bergwitz C, Prochnau A, Mayr B, Kramer FJ, Rittierodt M, Berten HL, Hausamen JE, Brabant G. J Inherit Metab Dis. 2001 Nov. PMID: 11768584.", + "Familial isolated parathyroid adenoma in a consanguineous family. Bergwitz C, Bremer B, Soudah B, Mayr B, Brabant G. J Endocrinol Invest. 2001 May. PMID: 11407655.", + "Wnts differentially regulate colony growth and differentiation of chondrogenic rat calvaria cells. Bergwitz C, Wendlandt T, Kispert A, Brabant G. Biochim Biophys Acta. 2001 Apr 23. PMID: 11336784.", + "A versatile chondrogenic rat calvaria cell line R-tTA-24 that permits tetracycline-regulated gene expression. Bergwitz C, Wendlandt T, Pötter E, Glomb I, Gras K, von zur Mühlen A, Brabant G. Histochem Cell Biol. 2000 Feb. PMID: 10766267.", + "A G protein-coupled receptor from zebrafish is activated by human parathyroid hormone and not by human or teleost parathyroid hormone-related peptide. Implications for the evolutionary conservation of calcium-regulating peptide hormones. Rubin DA, Hellman P, Zon LI, Lobb CJ, Bergwitz C, Jüppner H. J Biol Chem. 1999 Aug 13. PMID: 10438471.", + "The cadherin-catenin system: implications for growth and differentiation of endocrine tissues. Pötter E, Bergwitz C, Brabant G. Endocr Rev. 1999 Apr. PMID: 10204118.", + "Identification, functional characterization, and developmental expression of two nonallelic parathyroid hormone (PTH)/PTH-related peptide receptor isoforms in Xenopus laevis (Daudin). Bergwitz C, Klein P, Kohno H, Forman SA, Lee K, Rubin D, Jüppner H. Endocrinology. 1998 Feb. PMID: 9449646.", + "Residues in the membrane-spanning and extracellular loop regions of the parathyroid hormone (PTH)-2 receptor determine signaling selectivity for PTH and PTH-related peptide. Bergwitz C, Jusseaume SA, Luck MD, Jüppner H, Gardella TJ. J Biol Chem. 1997 Nov 14. PMID: 9360953.", + "Cloning and characterization of the vitamin D receptor from Xenopus laevis. Li YC, Bergwitz C, Jüppner H, Demay MB. Endocrinology. 1997 Jun. PMID: 9165021.", + "Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin. Evidence for a common pattern of ligand-receptor interaction. Bergwitz C, Gardella TJ, Flannery MR, Potts JT Jr, Kronenberg HM, Goldring SR, Jüppner H. J Biol Chem. 1996 Oct 25. PMID: 8900113.", + "Pseudohypoparathyroidism type Ib is not caused by mutations in the coding exons of the human parathyroid hormone (PTH)/PTH-related peptide receptor gene. Schipani E, Weinstein LS, Bergwitz C, Iida-Klein A, Kong XF, Stuhrmann M, Kruse K, Whyte MP, Murray T, Schmidtke J. J Clin Endocrinol Metab. 1995 May. PMID: 7745008.", + "Rapid desensitization of parathyroid hormone dependent adenylate cyclase in perifused human osteosarcoma cells (SaOS-2). Bergwitz C, Abou-Samra AB, Hesch RD, Jüppner H. Biochim Biophys Acta. 1994 Jul 21. PMID: 8038214.", + "Polymorphism in exon M7 of the PTHR gene. Schipani E, Hustmyer FG, Bergwitz C, Jüppner H. Hum Mol Genet. 1994 Jul. PMID: 7981709.", + "Specific, high-affinity binding sites for angiotensin II on Mycoplasma hyorhinis. Bergwitz C, Madoff S, Abou-Samra AB, Jüppner H. Biochem Biophys Res Commun. 1991 Sep 30. PMID: 1718269.", + "", + "1 Event you could attend in November 2025 Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Blumenfeld Lab", + "lab_url": "https://medicine.yale.edu/lab/blumenfeld/", + "research_bio": "INFORMATION FOR Copy Link Consciousness is central to human life, allowing people to experience and respond to the world. Our laboratory investigates brain mechanisms of normal consciousness and when consciousness is impaired by epileptic seizures. We use powerful brain imaging techniques, electrical measurements and testing of behavior. By understanding the mechanisms of consciousness, we hope to restore normal consciousness to patients with epilepsy and other brain disorders. Our work investigates brain networks including the cerebral cortex interacting with deeper structures such as the thalamus and brainstem. We use single cell and larger-scale electrical recordings, multi-modal neuroimaging with functional magnetic resonance imaging (fMRI), neurotransmitter measurements and other techniques. Our goal is to rapidly translate findings from the research lab to practical applications—greatly improving quality of life. Copy Link Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/blumenfeld/publications/", + "publications": [ + "Yale School of Medicine /", + "Neurology /", + "Research", + "Publications", + "Lab Members", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Publications", + "Lab Members", + "", + "", + "", + "", + "", + "", + "Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures. McCafferty C, Gruenbaum BF, Tung R, Li JJ, Zheng X, Salvino P, Vincent P, Kratochvil Z, Ryu JH, Khalaf A, Swift K, Akbari R, Islam W, Antwi P, Johnson EA, Vitkovskiy P, Sampognaro J, Freedman IG, Kundishora A, Depaulis A, David F, Crunelli V, Sanganahalli BG, Herman P, Hyder F, Blumenfeld H. Nat Commun. 2023 Jan 10; 2023 Jan 10. PMID: 36627270.", + "Human visual consciousness involves large scale cortical and subcortical networks independent of task report and eye movement activity. Kronemer SI, Aksen M, Ding JZ, Ryu JH, Xin Q, Ding Z, Prince JS, Kwon H, Khalaf A, Forman S, Jin DS, Wang K, Chen K, Hu C, Agarwal A, Saberski E, Wafa SMA, Morgan OP, Wu J, Christison-Lagay KL, Hasulak N, Morrell M, Urban A, Todd Constable R, Pitts M, Mark Richardson R, Crowley MJ, Blumenfeld H. Nat Commun. 2022 Nov 29; 2022 Nov 29. PMID: 36446792.", + "Early cortical signals in visual stimulus detection. Kwon H, Kronemer SI, Christison-Lagay KL, Khalaf A, Li J, Ding JZ, Freedman NC, Blumenfeld H. Neuroimage. 2021 Dec 1; 2021 Sep 21. PMID: 34560270.", + "The pulse: transient fMRI signal increases in subcortical arousal systems during transitions in attention. Li R, Ryu JH, Vincent P, Springer M, Kluger D, Levinsohn EA, Chen Y, Chen H, Blumenfeld H. Neuroimage. 2021 May 15; 2021 Feb 27. PMID: 33647499.", + "A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception. Herman WX, Smith RE, Kronemer SI, Watsky RE, Chen WC, Gober LM, Touloumes GJ, Khosla M, Raja A, Horien CL, Morse EC, Botta KL, Hirsch LJ, Alkawadri R, Gerrard JL, Spencer DD, Blumenfeld H. Cereb Cortex. 2019 Feb 1. PMID: 29194517.", + "Restoring Conscious Arousal During Focal Limbic Seizures with Deep Brain Stimulation. Kundishora AJ, Gummadavelli A, Ma C, Liu M, McCafferty C, Schiff ND, Willie JT, Gross RE, Gerrard J, Blumenfeld H. Cereb Cortex. 2017 Mar 1. PMID: 26941379.", + "Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study. Guo JN, Kim R, Chen Y, Negishi M, Jhun S, Weiss S, Ryu JH, Bai X, Xiao W, Feeney E, Rodriguez-Fernandez J, Mistry H, Crunelli V, Crowley MJ, Mayes LC, Constable RT, Blumenfeld H. Lancet Neurol. 2016 Dec. PMID: 27839650.", + "Decreased subcortical cholinergic arousal in focal seizures. Motelow JE, Li W, Zhan Q, Mishra AM, Sachdev RN, Liu G, Gummadavelli A, Zayyad Z, Lee HS, Chu V, Andrews JP, Englot DJ, Herman P, Sanganahalli BG, Hyder F, Blumenfeld H. Neuron. 2015 Feb 4. PMID: 25654258.", + "Where fMRI and electrophysiology agree to disagree: corticothalamic and striatal activity patterns in the WAG/Rij rat. Mishra AM, Ellens DJ, Schridde U, Motelow JE, Purcaro MJ, DeSalvo MN, Enev M, Sanganahalli BG, Hyder F, Blumenfeld H. J Neurosci. 2011 Oct 19. PMID: 22016539.", + "Cortical and subcortical networks in human secondarily generalized tonic-clonic seizures. Blumenfeld H, Varghese GI, Purcaro MJ, Motelow JE, Enev M, McNally KA, Levin AR, Hirsch LJ, Tikofsky R, Zubal IG, Paige AL, Spencer SS. Brain. 2009 Apr; 2009 Apr 1. PMID: 19339252.", + "Early treatment suppresses the development of spike-wave epilepsy in a rat model. Blumenfeld H, Klein JP, Schridde U, Vestal M, Rice T, Khera DS, Bashyal C, Giblin K, Paul-Laughinghouse C, Wang F, Phadke A, Mission J, Agarwal RK, Englot DJ, Motelow J, Nersesyan H, Waxman SG, Levin AR. Epilepsia. 2008 Mar; 2007 Dec 6. PMID: 18070091.", + "Auditory sensory processing induces cortical and thalamic event-related desynchronization in the mouse. McGill SH, Xin Q, Yadav T, Zhao CW, Paszkowski P, Darby F, Guha M, Nguyen T, Jin DS, Nir Y, Liu J, Sieu LA, Blumenfeld H. PLoS One. 2025; 2025 Oct 27. PMID: 41144455.", + "A practical guide to the updated seizure classification 2025. Beniczky S, Trinka E, Wirrell E, Singh MB, Blumenfeld H, Bogacz Fressola A, Cendes F, Craiu D, Frauscher B, Jansen FE, Kahane P, Kander V, Kishk N, Khoo CS, Lizcano A, De Palma L, Ryvlin P, Specchio N, Sperling MR, Tatum W, Yacubian EM, Wilmshurst J, Cross JH. Epileptic Disord. 2025 Oct 13; 2025 Oct 13. PMID: 41081650.", + "Digital Response Test in Epilepsy assesses interictal epileptiform discharge effects in real time. von Allmen A, Lu D, Jagella C, Abukhadra Y, Markhus R, Triesch J, Gopaul M, Hirsch LJ, Rosenow F, Blumenfeld H, Krestel H. Epilepsia. 2025 Oct 3; 2025 Oct 3. PMID: 41042536.", + "Dual-outcome Prediction of Post-Ischemic Stroke Epilepsy and Mortality Using Multimodal Quantitative Biomarkers. Chen Y, Soto AL, Sudhakar TD, Zubair A, Sun H, Jing J, Ge W, Loman L, Sivaraju A, Petersen N, Hirsch LJ, Blumenfeld H, Zafar SF, Struck AF, Sheth KN, Gilmore EJ, Westover MB, Kim JA. medRxiv. 2025 Sep 27; 2025 Sep 27. PMID: 41040677.", + "Relationship Between Brain Activity and Impaired Consciousness in Frontal Lobe Seizures. Salardini E, Vaddiparti A, Kumar A, Qu J, Martin RA, Gebre RZ, Arencibia CA, Dhakar MB, Grover EH, Quraishi IH, Sternberg EJ, George I, Sivaraju A, Bonito J, Zaveri HP, Gober LM, Ahammad S, Ghoshal S, Wu K, Farooque P, Hirsch LJ, Damisah E, Gerrard JL, Spencer DD, Yoo JY, Young JJ, Friedman D, Shum J, Blumenfeld H. Neurology. 2025 Sep 23; 2025 Sep 2. PMID: 40893057.", + "Lateral septal inhibition of nucleus basalis through direct and indirect pathways in focal limbic seizures. Liu J, Sieu LA, Shi I, Doan V, Liu S, Sun C, Brodovskaya A, Kapur J, Cardin JA, Blumenfeld H. bioRxiv. 2025 Sep 17; 2025 Sep 17. PMID: 41000632.", + "Decreased cholinergic neuronal firing in a mouse model of temporal lobe seizures with impaired consciousness. Liu S, Paszkowski P, Qu J, Sieu LA, Liu J, Valcarce-Aspegren M, Khan W, McGill S, Lee D, Duque A, Blumenfeld H. Epilepsia. 2025 Sep 16; 2025 Sep 16. PMID: 40956639.", + "Effects of Centromedian Nucleus Stimulation on Interictal Scalp EEG Burden in Lennox-Gastaut Syndrome. Sivaraju A, Poe J, Blumenfeld H, Cukiert A. Stereotact Funct Neurosurg. 2025 Sep 1; 2025 Sep 1. PMID: 40889229.", + "Distinct spike-and-wave EEG profiles reveal susceptibility to fleeting/almost loss of consciousness (so-called blips) in generalized epilepsy. Matringe E, Khalaf A, Granchamp R, Vidal JR, Perrone-Bertolotti M, Blumenfeld H, Vercueil L. Epilepsia. 2025 Jul 30; 2025 Jul 30. PMID: 40736396.", + "Mapping of neurovascular and neurometabolic couplings by multimodal optical imaging. Herman P, Sanggaard S, James SD, Akif A, Mishra SK, Sanganahalli BG, Verhagen JV, Blumenfeld H, Hyder F. Cereb Cortex. 2025 Jul 1. PMID: 40624899.", + "Decreased locus coeruleus multiunit activity in a mouse model of temporal lobe seizures with impaired consciousness. Valcarce-Aspegren M, Paszkowski P, Liu S, Wu Q, McGill S, Sieu LA, Blumenfeld H. Exp Neurol. 2025 Jul; 2025 Apr 4. PMID: 40189126.", + "Adversarial testing of global neuronal workspace and integrated information theories of consciousness. Ferrante O, Gorska-Klimowska U, Henin S, Hirschhorn R, Khalaf A, Lepauvre A, Liu L, Richter D, Vidal Y, Bonacchi N, Brown T, Sripad P, Armendariz M, Bendtz K, Ghafari T, Hetenyi D, Jeschke J, Kozma C, Mazumder DR, Montenegro S, Seedat A, Sharafeldin A, Yang S, Baillet S, Chalmers DJ, Cichy RM, Fallon F, Panagiotaropoulos TI, Blumenfeld H, de Lange FP, Devore S, Jensen O, Kreiman G, Luo H, Boly M, Dehaene S, Koch C, Tononi G, Pitts M, Mudrik L, Melloni L. Nature. 2025 Jun; 2025 Apr 30. PMID: 40307561.", + "Updated classification of epileptic seizures: Position paper of the International League Against Epilepsy. Beniczky S, Trinka E, Wirrell E, Abdulla F, Al Baradie R, Alonso Vanegas M, Auvin S, Singh MB, Blumenfeld H, Bogacz Fressola A, Caraballo R, Carreno M, Cendes F, Charway A, Cook M, Craiu D, Ezeala-Adikaibe B, Frauscher B, French J, Gule MV, Higurashi N, Ikeda A, Jansen FE, Jobst B, Kahane P, Kishk N, Khoo CS, Vinayan KP, Lagae L, Lim KS, Lizcano A, McGonigal A, Perez-Gosiengfiao KT, Ryvlin P, Specchio N, Sperling MR, Stefan H, Tatum W, Tripathi M, Yacubian EM, Wiebe S, Wilmshurst J, Zhou D, Cross JH. Epilepsia. 2025 Jun; 2025 Apr 23. PMID: 40264351.", + "Shared subcortical arousal systems across sensory modalities during transient modulation of attention. Khalaf A, Lopez E, Li J, Horn A, Edlow BL, Blumenfeld H. Neuroimage. 2025 May 15; 2025 Apr 16. PMID: 40250641.", + "The neural activity of auditory conscious perception. Christison-Lagay KL, Khalaf A, Freedman NC, Micek C, Kronemer SI, Gusso MM, Kim L, Forman S, Ding J, Aksen M, Abdel-Aty A, Kwon H, Markowitz N, Yeagle E, Espinal E, Herrero J, Bickel S, Young J, Mehta A, Wu K, Gerrard J, Damisah E, Spencer D, Blumenfeld H. Neuroimage. 2025 Mar; 2025 Jan 19. PMID: 39832539.", + "Automatic responsiveness testing in epilepsy with wearable technology: The ARTiE Watch. Wheeler L, Kremen V, Mersereau C, Ornelas G, Yadav T, Cormier D, Derry A, Duque Lopez A, McQuown K, Sladky V, Benjamin C, Giacino J, Worrell G, Blumenfeld H. Epilepsia. 2025 Jan; 2024 Nov 19. PMID: 39559901.", + "Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness. Sieu LA, Singla S, Liu J, Zheng X, Sharafeldin A, Chandrasekaran G, Valcarce-Aspegren M, Niknahad A, Fu I, Doilicho N, Gummadavelli A, McCafferty C, Crouse RB, Perrenoud Q, Picciotto MR, Cardin JA, Blumenfeld H. Cell Rep. 2024 Dec 24; 2024 Dec 5. PMID: 39643969.", + "Neuronal rhythmicity and cortical arousal in a mouse model of absence epilepsy. Khan W, Chopra S, Zheng X, Liu S, Paszkowski P, Valcarce-Aspegren M, Sieu LA, Mcgill S, Mccafferty C, Blumenfeld H. Exp Neurol. 2024 Nov; 2024 Aug 14. PMID: 39151596.", + "Shared subcortical arousal systems across sensory modalities during transient modulation of attention. Khalaf A, Lopez E, Li J, Horn A, Edlow BL, Blumenfeld H. bioRxiv. 2024 Oct 1; 2024 Oct 1. PMID: 39345640.", + "Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb. James S, Sanggaard S, Akif A, Mishra SK, Sanganahalli BG, Blumenfeld H, Verhagen JV, Hyder F, Herman P. J Cereb Blood Flow Metab. 2023 Nov; 2023 Jun 21. PMID: 37340791.", + "Mapping Lesion-Related Epilepsy to a Human Brain Network. Schaper FLWVJ, Nordberg J, Cohen AL, Lin C, Hsu J, Horn A, Ferguson MA, Siddiqi SH, Drew W, Soussand L, Winkler AM, Simó M, Bruna J, Rheims S, Guenot M, Bucci M, Nummenmaa L, Staals J, Colon AJ, Ackermans L, Bubrick EJ, Peters JM, Wu O, Rost NS, Grafman J, Blumenfeld H, Temel Y, Rouhl RPW, Joutsa J, Fox MD. JAMA Neurol. 2023 Sep 1. PMID: 37399040.", + "Predictive Power of Interictal Epileptiform Discharges in Fitness-to-Drive Evaluation. Krestel H, Schreier DR, Sakiri E, von Allmen A, Abukhadra Y, Nirkko A, Steinlin M, Rosenow F, Markhus R, Schneider G, Jagella C, Mathis J, Blumenfeld H. Neurology. 2023 Aug 29; 2023 Jul 6. PMID: 37414567.", + "Quantitative epileptiform burden and electroencephalography background features predict post-traumatic epilepsy. Chen Y, Li S, Ge W, Jing J, Chen HY, Doherty D, Herman A, Kaleem S, Ding K, Osman G, Swisher CB, Smith C, Maciel CB, Alkhachroum A, Lee JW, Dhakar MB, Gilmore EJ, Sivaraju A, Hirsch LJ, Omay SB, Blumenfeld H, Sheth KN, Struck AF, Edlow BL, Westover MB, Kim JA. J Neurol Neurosurg Psychiatry. 2023 Mar; 2022 Oct 14. PMID: 36241423.", + "An adversarial collaboration protocol for testing contrasting predictions of global neuronal workspace and integrated information theory. Melloni L, Mudrik L, Pitts M, Bendtz K, Ferrante O, Gorska U, Hirschhorn R, Khalaf A, Kozma C, Lepauvre A, Liu L, Mazumder D, Richter D, Zhou H, Blumenfeld H, Boly M, Chalmers DJ, Devore S, Fallon F, de Lange FP, Jensen O, Kreiman G, Luo H, Panagiotaropoulos TI, Dehaene S, Koch C, Tononi G. PLoS One. 2023; 2023 Feb 10. PMID: 36763595.", + "Early neural activity changes associated with stimulus detection during visual conscious perception. Khalaf A, Kronemer SI, Christison-Lagay K, Kwon H, Li J, Wu K, Blumenfeld H. Cereb Cortex. 2023 Feb 7. PMID: 35446937.", + "Brain Mechanisms of Conscious Awareness: Detect, Pulse, Switch, and Wave. Blumenfeld H. Neuroscientist. 2023 Feb; 2021 Oct 11. PMID: 34632846.", + "Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures. McCafferty C, Gruenbaum BF, Tung R, Li JJ, Zheng X, Salvino P, Vincent P, Kratochvil Z, Ryu JH, Khalaf A, Swift K, Akbari R, Islam W, Antwi P, Johnson EA, Vitkovskiy P, Sampognaro J, Freedman IG, Kundishora A, Depaulis A, David F, Crunelli V, Sanganahalli BG, Herman P, Hyder F, Blumenfeld H. Nat Commun. 2023 Jan 10; 2023 Jan 10. PMID: 36627270.", + "Distinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures. Juan E, Górska U, Kozma C, Papantonatos C, Bugnon T, Denis C, Kremen V, Worrell G, Struck AF, Bateman LM, Merricks EM, Blumenfeld H, Tononi G, Schevon C, Boly M. Brain. 2023 Jan 5. PMID: 36383415.", + "Human visual consciousness involves large scale cortical and subcortical networks independent of task report and eye movement activity. Kronemer SI, Aksen M, Ding JZ, Ryu JH, Xin Q, Ding Z, Prince JS, Kwon H, Khalaf A, Forman S, Jin DS, Wang K, Chen K, Hu C, Agarwal A, Saberski E, Wafa SMA, Morgan OP, Wu J, Christison-Lagay KL, Hasulak N, Morrell M, Urban A, Todd Constable R, Pitts M, Mark Richardson R, Crowley MJ, Blumenfeld H. Nat Commun. 2022 Nov 29; 2022 Nov 29. PMID: 36446792.", + "More than a feeling: Scalp EEG and eye signals in conscious tactile perception. Gusso MM, Christison-Lagay KL, Zuckerman D, Chandrasekaran G, Kronemer SI, Ding JZ, Freedman NC, Nohama P, Blumenfeld H. Conscious Cogn. 2022 Oct; 2022 Sep 22. PMID: 36156359.", + "A machine-learning approach for predicting impaired consciousness in absence epilepsy. Springer M, Khalaf A, Vincent P, Ryu JH, Abukhadra Y, Beniczky S, Glauser T, Krestel H, Blumenfeld H. Ann Clin Transl Neurol. 2022 Oct; 2022 Sep 16. PMID: 36114696.", + "Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testing. Contreras Ramirez V, Patedakis Litvinov B, Gunawardane NA, Zhao CW, Yotter C, Quraishi IH, Blumenfeld H. Epileptic Disord. 2022 Oct 1. PMID: 35904040.", + "Subcortical Cognition: The Fruit Below the Rind. Janacsek K, Evans TM, Kiss M, Shah L, Blumenfeld H, Ullman MT. Annu Rev Neurosci. 2022 Jul 8; 2022 Apr 6. PMID: 35385670.", + "Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy. Sivaraju A, Hirsch L, Gaspard N, Farooque P, Gerrard J, Xu Y, Deng Y, Damisah E, Blumenfeld H, Spencer DD. Neurology. 2022 Jul 5; 2022 May 4. PMID: 35508395.", + "Seizure semiology: ILAE glossary of terms and their significance. Beniczky S, Tatum WO, Blumenfeld H, Stefan H, Mani J, Maillard L, Fahoum F, Vinayan KP, Mayor LC, Vlachou M, Seeck M, Ryvlin P, Kahane P. Epileptic Disord. 2022 Jun 1. PMID: 35770761.", + "Thalamic activations in rat brain by fMRI during tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimulations. Sanganahalli BG, Thompson GJ, Parent M, Verhagen JV, Blumenfeld H, Herman P, Hyder F. PLoS One. 2022; 2022 May 6. PMID: 35522646.", + "Testing awareness in focal seizures: Clinical practice and interpretation of current guidelines. Contreras Ramirez V, Vaddiparti A, Blumenfeld H. Ann Clin Transl Neurol. 2022 May; 2022 Apr 29. PMID: 35485201.", + "Reliability of patient self-report of cognition, awareness, and consciousness during seizures. Zhao CW, Gebre R, Baykara Y, Chen W, Vitkovskiy P, Li N, Johnson M, Chen EY, Kluger D, Blumenfeld H. Ann Clin Transl Neurol. 2022 Jan; 2022 Jan 11. PMID: 35014222.", + "Simulated driving in the epilepsy monitoring unit: Effects of seizure type, consciousness, and motor impairment. Kumar A, Martin R, Chen W, Bauerschmidt A, Youngblood MW, Cunningham C, Si Y, Ezeani C, Kratochvil Z, Bronen J, Thomson J, Riordan K, Yoo JY, Shirka R, Manganas L, Krestel H, Hirsch LJ, Blumenfeld H. Epilepsia. 2022 Jan; 2021 Nov 24. PMID: 34816425.", + "Early cortical signals in visual stimulus detection. Kwon H, Kronemer SI, Christison-Lagay KL, Khalaf A, Li J, Ding JZ, Freedman NC, Blumenfeld H. Neuroimage. 2021 Dec 1; 2021 Sep 21. PMID: 34560270.", + "Short-term changes in cortical physiological arousal measured by electroencephalography during thalamic centromedian deep brain stimulation. Martin RA, Cukiert A, Blumenfeld H. Epilepsia. 2021 Nov; 2021 Aug 18. PMID: 34405892.", + "Arousal and Consciousness in Focal Seizures. Blumenfeld H. Epilepsy Curr. 2021 Oct; 2021 Oct 24. PMID: 34924835.", + "Cortical low-frequency power correlates with behavioral impairment in animal model of focal limbic seizures. Gummadavelli A, Martin R, Goshay D, Sieu LA, Xu J, Gruenbaum BF, McCafferty C, Gerrard JL, Blumenfeld H. Epilepsia. 2021 Aug; 2021 Jul 9. PMID: 34240747.", + "The pulse: transient fMRI signal increases in subcortical arousal systems during transitions in attention. Li R, Ryu JH, Vincent P, Springer M, Kluger D, Levinsohn EA, Chen Y, Chen H, Blumenfeld H. Neuroimage. 2021 May 15; 2021 Feb 27. PMID: 33647499.", + "Absence seizures and their relationship to depression and anxiety: Evidence for bidirectionality. Gruenbaum BF, Sandhu MRS, Bertasi RAO, Bertasi TGO, Schonwald A, Kurup A, Gruenbaum SE, Freedman IG, Funaro MC, Blumenfeld H, Sanacora G. Epilepsia. 2021 May; 2021 Mar 10. PMID: 33751566.", + "Parallel pathways to decreased subcortical arousal in focal limbic seizures. Zhao CW, Feng L, Sieu LA, Pok B, Gummadavelli A, Blumenfeld H. Epilepsia. 2020 Dec; 2020 Nov 9. PMID: 33165921.", + "ILAE Neuroimaging Task Force highlight: Review MRI scans with semiology in mind. Federico P, Ng DW, Bernasconi A, Bernhardt B, Blumenfeld H, Cendes F, Chinvarun Y, Jackson GD, Morgan V, Rampp S, Vaudano AE, Wang I. Epileptic Disord. 2020 Oct 1. PMID: 33063671.", + "The connectivity index: an effective metric for grading epileptogenicity. Yan Q, Gaspard N, Zaveri HP, Blumenfeld H, Hirsch LJ, Spencer DD, Alkawadri R. J Neurosurg. 2020 Oct 1; 2019 Sep 27. PMID: 31561212.", + "Thalamic Stimulation Improves Postictal Cortical Arousal and Behavior. Xu J, Galardi MM, Pok B, Patel KK, Zhao CW, Andrews JP, Singla S, McCafferty CP, Feng L, Musonza ET, Kundishora AJ, Gummadavelli A, Gerrard JL, Laubach M, Schiff ND, Blumenfeld H. J Neurosci. 2020 Sep 16; 2020 Aug 21. PMID: 32826310.", + "MRI essentials in epileptology: a review from the ILAE Imaging Taskforce. Wang I, Bernasconi A, Bernhardt B, Blumenfeld H, Cendes F, Chinvarun Y, Jackson G, Morgan V, Rampp S, Vaudano AE, Federico P. Epileptic Disord. 2020 Aug 1. PMID: 32763869.", + "Detecting Seizures and Epileptiform Abnormalities in Acute Brain Injury. Singla S, Garcia GE, Rovenolt GE, Soto AL, Gilmore EJ, Hirsch LJ, Blumenfeld H, Sheth KN, Omay SB, Struck AF, Westover MB, Kim JA. Curr Neurol Neurosci Rep. 2020 Jul 27; 2020 Jul 27. PMID: 32715371.", + "Up and Down States of Cortical Neurons in Focal Limbic Seizures. Yue Z, Freedman IG, Vincent P, Andrews JP, Micek C, Aksen M, Martin R, Zuckerman D, Perrenoud Q, Neske GT, Sieu LA, Bo X, Cardin JA, Blumenfeld H. Cereb Cortex. 2020 May 14. PMID: 31800015.", + "Motivational Interviewing Techniques to Improve Psychotherapy Adherence and Outcomes for Patients With Psychogenic Nonepileptic Seizures. Tolchin B, Baslet G, Martino S, Suzuki J, Blumenfeld H, Hirsch LJ, Altalib H, Dworetzky BA. J Neuropsychiatry Clin Neurosci. 2020 Spring; 2019 Aug 30. PMID: 31466516.", + "Realistic driving simulation during generalized epileptiform discharges to identify electroencephalographic features related to motor vehicle safety: Feasibility and pilot study. Cohen E, Antwi P, Banz BC, Vincent P, Saha R, Arencibia CA, Ryu JH, Atac E, Saleem N, Tomatsu S, Swift K, Hu C, Krestel H, Farooque P, Levy S, Wu J, Crowley M, Vaca FE, Blumenfeld H. Epilepsia. 2020 Jan; 2019 Oct 24. PMID: 31646628.", + "Contralateral ictal ptosis: Is it a reliable lateralizing sign in epilepsy? Sheikh Z, Blumenfeld H, Hirsch LJ. Neurol Clin Pract. 2019 Dec. PMID: 32042495.", + "Investigation of patient and observer agreement on description of seizures at initial clinical visit. Saleem MN, Arencibia CA, McKenna K, Cristofaro S, Detyniecki K, Friedman D, French J, Blumenfeld H. Ann Clin Transl Neurol. 2019 Dec; 2019 Dec 5. PMID: 31808615.", + "Author response: Adherence with psychotherapy and treatment outcomes for psychogenic nonepileptic seizures. Tolchin B, Dworetzky BA, Martino S, Blumenfeld H, Hirsch LJ, Baslet G. Neurology. 2019 Nov 26. PMID: 31767663.", + "Default mode and visual network activity in an attention task: Direct measurement with intracranial EEG. Li J, Kronemer SI, Herman WX, Kwon H, Ryu JH, Micek C, Wu Y, Gerrard J, Spencer DD, Blumenfeld H. Neuroimage. 2019 Nov 1; 2019 Jul 8. PMID: 31295566.", + "WONOEP appraisal: Network concept from an imaging perspective. Wykes RC, Khoo HM, Caciagli L, Blumenfeld H, Golshani P, Kapur J, Stern JM, Bernasconi A, Dedeurwaerdere S, Bernasconi N. Epilepsia. 2019 Jul; 2019 Jun 9. PMID: 31179547.", + "Randomized controlled trial of motivational interviewing for psychogenic nonepileptic seizures. Tolchin B, Baslet G, Suzuki J, Martino S, Blumenfeld H, Hirsch LJ, Altalib H, Dworetzky BA. Epilepsia. 2019 May; 2019 Apr 13. PMID: 30980679.", + "Historical trend toward improved long-term outcome in childhood absence epilepsy. Morse E, Giblin K, Chung MH, Dohle C, Berg AT, Blumenfeld H. Epilepsy Res. 2019 May; 2019 Feb 25. PMID: 30856420.", + "Slowing less than 1 Hz is decreased near the seizure onset zone. Lundstrom BN, Boly M, Duckrow R, Zaveri HP, Blumenfeld H. Sci Rep. 2019 Apr 17; 2019 Apr 17. PMID: 30996228.", + "Mechanisms of decreased cholinergic arousal in focal seizures: In vivo whole-cell recordings from the pedunculopontine tegmental nucleus. Andrews JP, Yue Z, Ryu JH, Neske G, McCormick DA, Blumenfeld H. Exp Neurol. 2019 Apr; 2018 Dec 10. PMID: 30543800.", + "Association of Seizure Spread With Surgical Failure in Epilepsy. Andrews JP, Gummadavelli A, Farooque P, Bonito J, Arencibia C, Blumenfeld H, Spencer DD. JAMA Neurol. 2019 Apr 1. PMID: 30508033.", + "Driving status of patients with generalized spike-wave on EEG but no clinical seizures. Antwi P, Atac E, Ryu JH, Arencibia CA, Tomatsu S, Saleem N, Wu J, Crowley MJ, Banz B, Vaca FE, Krestel H, Blumenfeld H. Epilepsy Behav. 2019 Mar; 2018 Dec 21. PMID: 30580109.", + "Optimization of Parameters for Quantitative Analysis of (123)I-Ioflupane SPECT Images for Monitoring Progression of Parkinson Disease. Kuo PH, Eshghi N, Tinaz S, Blumenfeld H, Louis ED, Zubal G. J Nucl Med Technol. 2019 Mar; 2018 Aug 23. PMID: 30139881.", + "Adherence with psychotherapy and treatment outcomes for psychogenic nonepileptic seizures. Tolchin B, Dworetzky BA, Martino S, Blumenfeld H, Hirsch LJ, Baslet G. Neurology. 2019 Feb 12; 2019 Jan 4. PMID: 30610097.", + "Opportunities and challenges for a maturing science of consciousness. Michel M, Beck D, Block N, Blumenfeld H, Brown R, Carmel D, Carrasco M, Chirimuuta M, Chun M, Cleeremans A, Dehaene S, Fleming SM, Frith C, Haggard P, He BJ, Heyes C, Goodale MA, Irvine L, Kawato M, Kentridge R, King JR, Knight RT, Kouider S, Lamme V, Lamy D, Lau H, Laureys S, LeDoux J, Lin YT, Liu K, Macknik SL, Martinez-Conde S, Mashour GA, Melloni L, Miracchi L, Mylopoulos M, Naccache L, Owen AM, Passingham RE, Pessoa L, Peters MAK, Rahnev D, Ro T, Rosenthal D, Sasaki Y, Sergent C, Solovey G, Schiff ND, Seth A, Tallon-Baudry C, Tamietto M, Tong F, van Gaal S, Vlassova A, Watanabe T, Weisberg J, Yan K, Yoshida M. Nat Hum Behav. 2019 Feb. PMID: 30944453.", + "A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception. Herman WX, Smith RE, Kronemer SI, Watsky RE, Chen WC, Gober LM, Touloumes GJ, Khosla M, Raja A, Horien CL, Morse EC, Botta KL, Hirsch LJ, Alkawadri R, Gerrard JL, Spencer DD, Blumenfeld H. Cereb Cortex. 2019 Feb 1. PMID: 29194517.", + "Presurgical language fMRI: Technical practices in epilepsy surgical planning. Benjamin CFA, Dhingra I, Li AX, Blumenfeld H, Alkawadri R, Bickel S, Helmstaedter C, Meletti S, Bronen RA, Warfield SK, Peters JM, Reutens D, Połczyńska MM, Hirsch LJ, Spencer DD. Hum Brain Mapp. 2018 Oct; 2018 Jul 1. PMID: 29962111.", + "Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning. Benjamin CFA, Li AX, Blumenfeld H, Constable RT, Alkawadri R, Bickel S, Helmstaedter C, Meletti S, Bronen R, Warfield SK, Peters JM, Reutens D, Połczyńska M, Spencer DD, Hirsch LJ. Hum Brain Mapp. 2018 Jul; 2018 Mar 12. PMID: 29528160.", + "Semiquantitative Analysis of Dopamine Transporter Scans in Patients With Parkinson Disease. Tinaz S, Chow C, Kuo PH, Krupinski EA, Blumenfeld H, Louis ED, Zubal G. Clin Nucl Med. 2018 Jan. PMID: 29112012.", + "Seizures and Sleep in the Thalamus: Focal Limbic Seizures Show Divergent Activity Patterns in Different Thalamic Nuclei. Feng L, Motelow JE, Ma C, Biche W, McCafferty C, Smith N, Liu M, Zhan Q, Jia R, Xiao B, Duque A, Blumenfeld H. J Neurosci. 2017 Nov 22; 2017 Oct 24. PMID: 29066556.", + "Impairment of consciousness induced by bilateral electrical stimulation of the frontal convexity. Quraishi IH, Benjamin CF, Spencer DD, Blumenfeld H, Alkawadri R. Epilepsy Behav Case Rep. 2017; 2017 Sep 29. PMID: 29204347.", + "Restoring Conscious Arousal During Focal Limbic Seizures with Deep Brain Stimulation. Kundishora AJ, Gummadavelli A, Ma C, Liu M, McCafferty C, Schiff ND, Willie JT, Gross RE, Gerrard J, Blumenfeld H. Cereb Cortex. 2017 Mar 1. PMID: 26941379.", + "Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study. Guo JN, Kim R, Chen Y, Negishi M, Jhun S, Weiss S, Ryu JH, Bai X, Xiao W, Feeney E, Rodriguez-Fernandez J, Mistry H, Crunelli V, Crowley MJ, Mayes LC, Constable RT, Blumenfeld H. Lancet Neurol. 2016 Dec. PMID: 27839650.", + "Metabolic demands of neural-hemodynamic associated and disassociated areas in brain. Sanganahalli BG, Herman P, Rothman DL, Blumenfeld H, Hyder F. J Cereb Blood Flow Metab. 2016 Oct; 2016 Aug 25. PMID: 27562867.", + "Impaired Serotonergic Brainstem Function during and after Seizures. Zhan Q, Buchanan GF, Motelow JE, Andrews J, Vitkovskiy P, Chen WC, Serout F, Gummadavelli A, Kundishora A, Furman M, Li W, Bo X, Richerson GB, Blumenfeld H. J Neurosci. 2016 Mar 2. PMID: 26937010.", + "Human bedside evaluation versus automatic responsiveness testing in epilepsy (ARTiE). Touloumes G, Morse E, Chen WC, Gober L, Dente J, Lilenbaum R, Katzenstein E, Pacelli A, Johnson E, Si Y, Sivaraju A, Grover E, Khozein R, Cunningham C, Hirsch LJ, Blumenfeld H. Epilepsia. 2016 Jan; 2015 Dec 10. PMID: 26663137.", + "Optogenetic stimulation of cholinergic brainstem neurons during focal limbic seizures: Effects on cortical physiology. Furman M, Zhan Q, McCafferty C, Lerner BA, Motelow JE, Meng J, Ma C, Buchanan GF, Witten IB, Deisseroth K, Cardin JA, Blumenfeld H. Epilepsia. 2015 Dec; 2015 Nov 4. PMID: 26530287.", + "Epileptic auras and their role in driving safety in people with epilepsy. Punia V, Farooque P, Chen W, Hirsch LJ, Berg AT, Blumenfeld H. Epilepsia. 2015 Nov; 2015 Sep 22. PMID: 26391317.", + "Targeting Neuronal Networks with Combined Drug and Stimulation Paradigms Guided by Neuroimaging to Treat Brain Disorders. Faingold CL, Blumenfeld H. Neuroscientist. 2015 Oct; 2015 Jul 6. PMID: 26150315.", + "Neurostimulation to improve level of consciousness in patients with epilepsy. Gummadavelli A, Kundishora AJ, Willie JT, Andrews JP, Gerrard JL, Spencer DD, Blumenfeld H. Neurosurg Focus. 2015 Jun. PMID: 26030698.", + "Seizures and brain regulatory systems: consciousness, sleep, and autonomic systems. Sedigh-Sarvestani M, Blumenfeld H, Loddenkemper T, Bateman LM. J Clin Neurophysiol. 2015 Jun. PMID: 25233249.", + "Rhythmic 3-4Hz discharge is insufficient to produce cortical BOLD fMRI decreases in generalized seizures. Youngblood MW, Chen WC, Mishra AM, Enamandram S, Sanganahalli BG, Motelow JE, Bai HX, Frohlich F, Gribizis A, Lighten A, Hyder F, Blumenfeld H. Neuroimage. 2015 Apr 1; 2015 Jan 3. PMID: 25562830.", + "Commentary: The return of consciousness to epilepsy seizure classification. Blumenfeld H, Meador K, Jackson GD. Epilepsia. 2015 Mar; 2015 Mar 5. PMID: 25740196.", + "Decreased subcortical cholinergic arousal in focal seizures. Motelow JE, Li W, Zhan Q, Mishra AM, Sachdev RN, Liu G, Gummadavelli A, Zayyad Z, Lee HS, Chu V, Andrews JP, Englot DJ, Herman P, Sanganahalli BG, Hyder F, Blumenfeld H. Neuron. 2015 Feb 4. PMID: 25654258.", + "Thalamic stimulation to improve level of consciousness after seizures: evaluation of electrophysiology and behavior. Gummadavelli A, Motelow JE, Smith N, Zhan Q, Schiff ND, Blumenfeld H. Epilepsia. 2015 Jan; 2014 Dec 2. PMID: 25442843.", + "Cortical network switching: possible role of the lateral septum and cholinergic arousal. Li W, Motelow JE, Zhan Q, Hu YC, Kim R, Chen WC, Blumenfeld H. Brain Stimul. 2015 Jan-Feb; 2014 Sep 16. PMID: 25440289.", + "Altered functional connectivity in seizure onset zones revealed by fMRI intrinsic connectivity. Lee HW, Arora J, Papademetris X, Tokoglu F, Negishi M, Scheinost D, Farooque P, Blumenfeld H, Spencer DD, Constable RT. Neurology. 2014 Dec 9; 2014 Nov 12. PMID: 25391304.", + "The spatial and signal characteristics of physiologic high frequency oscillations. Alkawadri R, Gaspard N, Goncharova II, Spencer DD, Gerrard JL, Zaveri H, Duckrow RB, Blumenfeld H, Hirsch LJ. Epilepsia. 2014 Dec; 2014 Dec 3. PMID: 25470216.", + "A master switch for consciousness? Blumenfeld H. Epilepsy Behav. 2014 Aug; 2014 Aug 2. PMID: 25090656.", + "Consciousness as a useful concept in epilepsy classification. Blumenfeld H, Meador KJ. Epilepsia. 2014 Aug; 2014 Jun 30. PMID: 24981294.", + "Impaired consciousness in partial seizures is bimodally distributed. Cunningham C, Chen WC, Shorten A, McClurkin M, Choezom T, Schmidt CP, Chu V, Bozik A, Best C, Chapman M, Furman M, Detyniecki K, Giacino JT, Blumenfeld H. Neurology. 2014 May 13; 2014 Apr 11. PMID: 24727311.", + "Decreased resting functional connectivity after traumatic brain injury in the rat. Mishra AM, Bai X, Sanganahalli BG, Waxman SG, Shatillo O, Grohn O, Hyder F, Pitkänen A, Blumenfeld H. PLoS One. 2014; 2014 Apr 18. PMID: 24748279.", + "Long-term seizure remission in childhood absence epilepsy: might initial treatment matter? Berg AT, Levy SR, Testa FM, Blumenfeld H. Epilepsia. 2014 Apr; 2014 Feb 11. PMID: 24512528.", + "Ictal spread of medial temporal lobe seizures with and without secondary generalization: an intracranial electroencephalography analysis. Yoo JY, Farooque P, Chen WC, Youngblood MW, Zaveri HP, Gerrard JL, Spencer DD, Hirsch LJ, Blumenfeld H. Epilepsia. 2014 Feb; 2014 Jan 13. PMID: 24417694.", + "What is a seizure network? Long-range network consequences of focal seizures. Blumenfeld H. Adv Exp Med Biol. 2014. PMID: 25012367.", + "Epilepsy and driving: potential impact of transient impaired consciousness. Chen WC, Chen EY, Gebre RZ, Johnson MR, Li N, Vitkovskiy P, Blumenfeld H. Epilepsy Behav. 2014 Jan. PMID: 24436967.", + "Consciousness of seizures and consciousness during seizures: are they related? Detyniecki K, Blumenfeld H. Epilepsy Behav. 2014 Jan; 2013 Oct 12. PMID: 24126026.", + "", + "Calendar", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Bonde Artificial Heart Lab", + "lab_url": "https://medicine.yale.edu/lab/bonde/", + "research_bio": "INFORMATION FOR We believe a creative and imaginative environment is essential to innovation. This has been the cornerstone of our approach to solving complex problems in cardiac surgery. Major research groups: 1. Artificial heart development research group. 2. Heart Transplantation research group. 3. Outcomes based research group. Copy Link Copy Link Stretch R, Sauer CM, Yuh DD, Bonde P. National trends in the utilization of short-term mechanical circulatory support: Incidence, outcomes, and cost analysis. J Am Coll Cardiol. 2014;64(14):1407-1415 Sauer CM, Yuh DD, Bonde P. Extracorporeal membrane oxygenation (ECMO) use has increased by 433% in adults in the united states from 2006 to 2011. ASAIO J. 2014 Bellumkonda L, Subrahmanyan L, Jacoby D, Bonde P. Left ventricular assist device pump thrombosis: Is there a role for glycoprotein IIb/IIIa inhibitors? ASAIO J. 2014;60(1):134-136.Letzen BS, Matouk CC, Bonde P. Particle embolization for the treatment of life-threatening epistaxis in a left ventricular assist device patient. ASAIO J. 2014.Stretch R, Bonde P. Successful use of extracorporeal membrane oxygenation for respiratory failure in pulmonary chronic graft-versus-host disease. ASAIO J. 2014;60(1):122-123.Wang JX, Smith JR, Bonde P. Energy transmission and power sources for mechanical circulatory support devices to achieve total implantability. Ann Thorac Surg. 2014;97(4):1467-1474.Waters BH, Smith JR, Bonde P. Innovative free-range resonant electrical energy delivery system (FREE-D system) for a ventricular assist device using wireless power. ASAIO J. 2014;60(1):31-37. Jawitz OK, G Jawitz N, Yuh DD, Bonde P. Impact of ABO compatibility on outcomes after heart transplantation in a national cohort during the past decade. J Thorac Cardiovasc Surg. 2013;146(5):1239-45; discussion 1245-6. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/bonde/pubs/", + "publications": [ + "Yale School of Medicine /", + "Surgery /", + "Research Bonde I Artificial Heart Bonde II Temporary LVAD and RVAD System Bonde Portable ECMO System FREE-D Wireless Energy Transfer System", + "Bonde I Artificial Heart", + "Bonde II Temporary LVAD and RVAD System", + "Bonde Portable ECMO System", + "FREE-D Wireless Energy Transfer System", + "Opportunities", + "Multimedia FREE-D Wireless Simulation in Surgical Education", + "FREE-D Wireless", + "Simulation in Surgical Education", + "News", + "People", + "Support", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Multimedia", + "People", + "Publications", + "Opportunities", + "News", + "Support", + "", + "", + "", + "", + "", + "", + "Clinical application and management of temporary mechanical circulatory support: A clinical consensus. Dong N, Chen L, Chen X, Wang H, Xiao Y, Wang X, Huang J, Yan Y, Bonde P, Sodha N, Atluri P, Maureira JP, Vincentelli A, Yanase M, Wang Y, Zhang H, Hou X, Takami Y, Leprince P, Folliguet T, Sellke FW. Chin Med J (Engl). 2024 May 20; 2023 Dec 26. PMID: 38155554.", + "Futuristic perspectives: novel MCS devices. Bonde R, Bonde P. Indian J Thorac Cardiovasc Surg. 2023 Jul; 2023 May 8. PMID: 37525706.", + "Resonantly Coupled High-Efficiency Sensors for Assessment of Ventricular Chamber Size for Autonomous Control of Left Ventricular Assist Device. Palagani Y, Sorkin E, Bonde R, Bahel P, Bonde P. ASAIO J. 2023 Jan 1; 2022 Nov 7. PMID: 36346948.", + "First Transfemoral Implantation of a Novel Transcatheter Valve in an LVAD Patient With Aortic Insufficiency. Ranard LS, Kaple R, Khalique OK, Agarwal V, Bellumkonda L, Bonde P, George I, Uriel N, Leon MB, Vahl TP. JACC Case Rep. 2021 Dec 1; 2021 Dec 1. PMID: 34917959.", + "Impact of Preoperative Lymphopenia on Survival Following Left Ventricular Assist Device Placement. Stawiarski K, Agboola O, Park J, Geirsson A, Jacoby D, Bellumkonda L, Ahmad T, Chou J, Lee F, Mangi A, Bonde P. ASAIO J. 2021 Jun 1. PMID: 33074860.", + "Biologically Inspired, Open, Helicoid Impeller Design for Mechanical Circulatory Assist. Park J, Oki K, Hesselmann F, Geirsson A, Kaufmann T, Bonde P. ASAIO J. 2020 Aug. PMID: 32740350.", + "Association of Clinical Outcomes With Left Ventricular Assist Device Use by Bridge to Transplant or Destination Therapy Intent: The Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy With HeartMate 3 (MOMENTUM 3) Randomized Clinical Trial. Goldstein DJ, Naka Y, Horstmanshof D, Ravichandran AK, Schroder J, Ransom J, Itoh A, Uriel N, Cleveland JC Jr, Raval NY, Cogswell R, Suarez EE, Lowes BD, Kim G, Bonde P, Sheikh FH, Sood P, Farrar DJ, Mehra MR. JAMA Cardiol. 2020 Apr 1. PMID: 31939996.", + "Improving Outcomes in INTERMACS Category 1 Patients with Pre-LVAD, Awake Venous-Arterial Extracorporeal Membrane Oxygenation Support. Mori M, McCloskey G, Geirsson A, Mangi AA, Yun JJ, Jacoby D, Ahmad T, Bellumkonda L, Lee F, Chen ME, Bonde P. ASAIO J. 2019 Nov/Dec. PMID: 30664019.", + "Wave Intensity Analysis of Right Ventricular Function during Pulsed Operation of Rotary Left Ventricular Assist Devices. Bouwmeester JC, Park J, Valdovinos J, Bonde P. ASAIO J. 2019 Jul. PMID: 29863635.", + "Quantification of Pulsed Operation of Rotary Left Ventricular Assist Devices with Wave Intensity Analysis. Bouwmeester JC, Park J, Geirsson A, Valdovinos J, Bonde P. ASAIO J. 2019 May/Jun. PMID: 29863632.", + "Electrical power to run ventricular assist devices using the Free-range Resonant Electrical Energy Delivery system. Waters BH, Park J, Bouwmeester JC, Valdovinos J, Geirsson A, Sample AP, Smith JR, Bonde P. J Heart Lung Transplant. 2018 Dec; 2018 Aug 11. PMID: 30228086.", + "Design and Development of a Miniaturized Percutaneously Deployable Wireless Left Ventricular Assist Device: Early Prototypes and Feasibility Testing. Letzen B, Park J, Tuzun Z, Bonde P. ASAIO J. 2018 Mar/Apr. PMID: 28938307.", + "Plasma Levels of MicroRNA-155 Are Upregulated with Long-Term Left Ventricular Assist Device Support. Wang T, O'Brien EC, Rogers JG, Jacoby DL, Chen ME, Testani JM, Bowles DE, Milano CA, Felker GM, Patel CB, Bonde PN, Ahmad T. ASAIO J. 2017 Sep/Oct. PMID: 28319523.", + "Options for temporary mechanical circulatory support. Saffarzadeh A, Bonde P. J Thorac Dis. 2015 Dec. PMID: 26793330.", + "Particle embolization for the treatment of life-threatening epistaxis in a left ventricular assist device patient. Letzen BS, Matouk CC, Bonde P. ASAIO J. 2015 Jan-Feb. PMID: 25248039.", + "National trends in the utilization of short-term mechanical circulatory support: incidence, outcomes, and cost analysis. Stretch R, Sauer CM, Yuh DD, Bonde P. J Am Coll Cardiol. 2014 Oct 7. PMID: 25277608.", + "Energy transmission and power sources for mechanical circulatory support devices to achieve total implantability. Wang JX, Smith JR, Bonde P. Ann Thorac Surg. 2014 Apr; 2014 Feb 12. PMID: 24530103.", + "Left ventricular assist device pump thrombosis: is there a role for glycoprotein IIb/IIIa inhibitors? Bellumkonda L, Subrahmanyan L, Jacoby D, Bonde P. ASAIO J. 2014 Jan-Feb. PMID: 24335386.", + "Innovative Free-range Resonant Electrical Energy Delivery system (FREE-D System) for a ventricular assist device using wireless power. Waters BH, Smith JR, Bonde P. ASAIO J. 2014 Jan-Feb. PMID: 24299972.", + "Implantable physiologic controller for left ventricular assist devices with telemetry capability. Asgari SS, Bonde P. J Thorac Cardiovasc Surg. 2014 Jan; 2013 Oct 29. PMID: 24176267.", + "Ventricular assist device therapy for heart failure--past, present, and future. Bellumkonda L, Bonde P. Int Anesthesiol Clin. 2012 Summer. PMID: 22735723.", + "Model for end-stage liver disease score predicts adverse events related to ventricular assist device therapy. Bonde P, Ku NC, Genovese EA, Bermudez CA, Bhama JK, Ciarleglio MM, Cong X, Teuteberg JJ, Kormos RL. Ann Thorac Surg. 2012 May; 2012 Apr 4. PMID: 22480391.", + "Prognosis of right ventricular failure in patients with left ventricular assist device based on decision tree with SMOTE. Wang Y, Simon M, Bonde P, Harris BU, Teuteberg JJ, Kormos RL, Antaki JF. IEEE Trans Inf Technol Biomed. 2012 May; 2012 Feb 10. PMID: 22334033.", + "Ventricular assist device therapy in post-cardiotomy cardiogenic shock: historical outcomes and current trends. Nasir A, Bonde P, Graham AN. Interact Cardiovasc Thorac Surg. 2012 May; 2012 Feb 7. PMID: 22314011.", + "Decision tree for adjuvant right ventricular support in patients receiving a left ventricular assist device. Wang Y, Simon MA, Bonde P, Harris BU, Teuteberg JJ, Kormos RL, Antaki JF. J Heart Lung Transplant. 2012 Feb; 2011 Dec 14. PMID: 22168963.", + "Toward total implantability using free-range resonant electrical energy delivery system: achieving untethered ventricular assist device operation over large distances. Waters B, Sample A, Smith J, Bonde P. Cardiol Clin. 2011 Nov; 2011 Oct 2. PMID: 22062212.", + "Combining tricuspid valve repair with double lung transplantation in patients with severe pulmonary hypertension, tricuspid regurgitation, and right ventricular dysfunction. Shigemura N, Sareyyupoglu B, Bhama J, Bonde P, Thacker J, Bermudez C, Gries C, Crespo M, Johnson B, Pilewski J, Toyoda Y. Chest. 2011 Oct; 2011 Jun 23. PMID: 21700686.", + "A novel strategy for prevention of post-operative atrial arrhythmias in patients undergoing lung transplantation. Bazaz R, Salizzoni S, Bonde P, Espinoza A, Toyoda Y. J Heart Lung Transplant. 2010 Jun; 2010 Mar 29. PMID: 20347340.", + "Complete mechanical circulatory support using ventricular assist devices for post-cardiotomy biventricular failure. Nwaejike N, Bonde P, Campalani G. Ulster Med J. 2008 Jan. PMID: 18269116.", + "Impact of donor lung organisms on post-lung transplant pneumonia. Bonde PN, Patel ND, Borja MC, Allan SH, Barreiro CJ, Williams JA, Thakur NA, Orens JB, Conte JV. J Heart Lung Transplant. 2006 Jan; 2005 Nov 2. PMID: 16399537.", + "Surgical ventricular remodeling for patients with clinically advanced congestive heart failure and severe left ventricular dysfunction. Patel ND, Barreiro CJ, Williams JA, Bonde PN, Waldron M, Natori S, Bluemke DA, Conte JV. J Heart Lung Transplant. 2005 Dec; 2005 Sep 15. PMID: 16364872.", + "Surgical ventricular remodeling for multiterritory myocardial infarction: defining a new patient population. Patel ND, Williams JA, Barreiro CJ, Bonde PN, Waldron MM, Chang DC, Bluemke DA, Conte JV. J Thorac Cardiovasc Surg. 2005 Dec; 2005 Oct 26. PMID: 16308018.", + "Sputum retention after lung operation: prospective, randomized trial shows superiority of prophylactic minitracheostomy in high-risk patients. Bonde P, Papachristos I, McCraith A, Kelly B, Wilson C, McGuigan JA, McManus K. Ann Thorac Surg. 2002 Jul. PMID: 12118758.", + "Lung surgery: identifying the subgroup at risk for sputum retention. Bonde P, McManus K, McAnespie M, McGuigan J. Eur J Cardiothorac Surg. 2002 Jul. PMID: 12103367.", + "Brady Memorial Laboratory 310 Cedar Street New Haven, CT 06520-8023", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Bordey Lab", + "lab_url": "https://medicine.yale.edu/lab/bordey/", + "research_bio": "INFORMATION FOR The brain is a wonderful and mysterious machine, which makes us who we are. The activity of billions of neurons and glia orchestrate our thoughts and daily life. However, alterations in the number of neurons, their misplacement, or changes in the way they receive, handle, or send information can negatively impact our brain function and our lives. A mutation in a single gene can lead to such alterations resulting in a specific pathology and disorder. Our Mission is to understand how a mutated, dysfunctional protein will lead to abnormal brain formation and function. Our attention has been focused on the mammalian Target of Rapamycin, mTOR. mTOR is a converging point in cell signaling, or in other terms an intracellular hub, that receives signals from diverse intracellular routes and extracellular ligands. Importantly, mTOR is dysregulated in many neurological disorders. These disorders referred to as mTORopathies include (but are not limited to) Tuberous Sclerosis Complex (TSC), autism, Alzheimer's disease, and Schizophrenia. We have focused on TSC. TSC is the prototypical mTORopathy in whichTsc1orTsc2mutations lead to mTOR hyperactivity. In TSC, epilepsy due to the presence of cortical malformations is observed in 75-85% of the patients where seizures often begin during the first year of life as infantile spasms. More than 50% of affected children exhibit mental retardation and cognitive delay, with many exhibiting autistic traits and more than 60% have neuropsychiatric problems. These neurological symptoms are thought to be independent of the lesions but rather result from subtle developmental abnormalities and synaptic dysfunction. Our work has the following three lines of research related to the following keywords: mTOR, Neural stem cell, Neurogenesis, Cognitive functions, mTORopathies", + "publications_page": "https://medicine.yale.edu/lab/bordey/publications/", + "publications": [ + "Yale School of Medicine /", + "Neurosurgery /", + "Research", + "News", + "People Past Members", + "Past Members", + "Contact", + "Publications", + "Donate", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "Donate", + "News", + "Contact", + "", + "", + "", + "", + "", + "", + "Aberrant HCN4 channel expression: Impacts on neuronal excitability and implications for epilepsy pathogenesis. Spyrou J, Escobar I, Bordey A, Reid CA. Br J Pharmacol. 2025 Dec; 2025 Oct 13. PMID: 41084323.", + "A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia. Elliott SD, Ready PJ, Wrinn CM, Ma Q, Edward M, Niescier RF, Escobar I, Sun J, Ganga AK, McAtee CK, Atiş İS, Koleske AJ, Bordey A, Breslow DK. Sci Adv. 2025 Oct 31; 2025 Oct 29. PMID: 41160700.", + "Relative roles of HCN4 and synaptic excitation in pyramidal neuron firing rates in a hyperactive Rheb-mTOR condition. Chatzikalymniou AP, Getz SA, Xu Y, Patel DR, Soltesz I, Bordey A. Epilepsia. 2025 Sep; 2025 Jun 13. PMID: 40512428.", + "TSC-mTORC1 Pathway in Postnatal V-SVZ Neurodevelopment. Feliciano DM, Bordey A. Biomolecules. 2025 Apr 12; 2025 Apr 12. PMID: 40305300.", + "Reducing Filamin A Restores Cortical Synaptic Connectivity and Early Social Communication Following Cellular Mosaicism in Autism Spectrum Disorder Pathways. Binder MS, Escobar I, Xu Y, Sokolov AM, Zhang L, Bordey A. J Neurosci. 2024 Sep 25; 2024 Sep 25. PMID: 39164108.", + "The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function. Nguyen LH, Xu Y, Nair M, Bordey A. Elife. 2024 Feb 27; 2024 Feb 27. PMID: 38411613.", + "The mTOR pathway genes mTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function. Nguyen LH, Xu Y, Nair M, Bordey A. bioRxiv. 2024 Jan 6; 2024 Jan 6. PMID: 37609221.", + "mTOR in Acquired and Genetic Models of Epilepsy. Wong M, Bordey A, Danzer SC. 2024. PMID: 39637117.", + "Semi-natural housing rescues social behavior and reduces repetitive exploratory behavior of BTBR autistic-like mice. Binder MS, Bordey A. Sci Rep. 2023 Sep 27; 2023 Sep 27. PMID: 37758896.", + "Advances in glioma models using in vivo electroporation to highjack neurodevelopmental processes. Zhang L, Bordey A. Biochim Biophys Acta Rev Cancer. 2023 Sep; 2023 Jul 9. PMID: 37433417.", + "The Novel Somatosensory Nose-Poke Adapted Paradigm (SNAP) Is an Effective Tool to Assess Differences in Tactile Sensory Preferences in Autistic-Like Mice. Binder MS, Bordey A. eNeuro. 2023 Aug; 2023 Aug 30. PMID: 37596047.", + "In Utero Electroporated Neurons for Medium-Throughput Screening of Compounds Regulating Neuron Morphology. Sokolov AM, Aurich M, Bordey A. eNeuro. 2023 Aug; 2023 Aug 28. PMID: 37620147.", + "4E-BP1 expression in embryonic postmitotic neurons mitigates mTORC1-induced cortical malformations and behavioral seizure severity but does not prevent epilepsy in mice. Nguyen LH, Sharma M, Bordey A. Front Neurosci. 2023; 2023 Aug 23. PMID: 37680968.", + "KIF4 Gene Variant's Disruption of PARP1 Signaling Increases Anxiety and Seizure Susceptibility. Bordey A. Epilepsy Curr. 2023 Jul-Aug; 2023 May 22. PMID: 37662464.", + "Cannabinoid regulation of neurons in the dentate gyrus during epileptogenesis: Role of CB1R-associated proteins and downstream pathways. Lafourcade CA, Sparks FT, Bordey A, Wyneken U, Mohammadi MH. Epilepsia. 2023 Jun; 2023 Mar 20. PMID: 36869624.", + "Loss of PTEN phosphorylation via single point mutation alters cortical connectivity and behaviour. Binder M, Bordey A. Brain. 2022 Oct 21. PMID: 36148582.", + "Current Review in Basic Science: Animal Models of Focal Cortical Dysplasia and Epilepsy. Nguyen LH, Bordey A. Epilepsy Curr. 2022 Jul-Aug; 2022 Apr 22. PMID: 36187145.", + "Expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy. Nguyen LH, Xu Y, Mahadeo T, Zhang L, Lin TV, Born HA, Anderson AE, Bordey A. Brain. 2022 May 24. PMID: 34849602.", + "Neuro2D Lies at the Nexus of Autism, Epilepsy, and Intellectual Disabilities. Bordey A. Epilepsy Curr. 2022 Mar-Apr; 2022 Apr 4. PMID: 35444512.", + "Inhibition of MEK-ERK signaling reduces seizures in two mouse models of tuberous sclerosis complex. Nguyen LH, Leiser SC, Song D, Brunner D, Roberds SL, Wong M, Bordey A. Epilepsy Res. 2022 Mar; 2022 Feb 18. PMID: 35219048.", + "Dual in Utero Electroporation in Mice to Manipulate Two Specific Neuronal Populations in the Developing Cortex. Zhang L, Getz SA, Bordey A. Front Bioeng Biotechnol. 2021; 2022 Jan 12. PMID: 35096799.", + "Preimplantation factor modulates oligodendrocytes by H19-induced demethylation of NCOR2. Spinelli M, Boucard C, Ornaghi S, Schoeberlein A, Irene K, Coman D, Hyder F, Zhang L, Haesler V, Bordey A, Barnea E, Paidas M, Surbek D, Mueller M. JCI Insight. 2021 Oct 22; 2021 Oct 22. PMID: 34676826.", + "CD-1 Outbred Mice Produce Less Variable Ultrasonic Vocalizations Than FVB Inbred Mice, While Displaying a Similar Developmental Trajectory. Binder MS, Shi HD, Bordey A. Front Psychiatry. 2021; 2021 Aug 13. PMID: 34475829.", + "Corrigendum: Convergent and Divergent Mechanisms of Epileptogenesis in mTORopathies. Nguyen LH, Bordey A. Front Neuroanat. 2021; 2021 Jul 6. PMID: 34295225.", + "Treating Post-Traumatic Seizures to Limit Tau Accumulation in Larval Zebrafish. Bordey A. Epilepsy Curr. 2021 Jul-Aug; 2021 Apr 29. PMID: 34690568.", + "Treating Seizures With Low-Frequency Electrical Stimulation. Bordey A. Epilepsy Curr. 2021 May-Jun; 2021 Mar 25. PMID: 34867103.", + "Small Extracellular Vesicles Control Dendritic Spine Development through Regulation of HDAC2 Signaling. Zhang L, Lin TV, Yuan Q, Sadoul R, Lam TT, Bordey A. J Neurosci. 2021 Apr 28; 2021 Mar 19. PMID: 33741723.", + "Convergent and Divergent Mechanisms of Epileptogenesis in mTORopathies. Nguyen LH, Bordey A. Front Neuroanat. 2021; 2021 Apr 9. PMID: 33897381.", + "Rab27a-Dependent Paracrine Communication Controls Dendritic Spine Formation and Sensory Responses in the Barrel Cortex. Zhang L, Zhang X, Hsieh LS, Lin TV, Bordey A. Cells. 2021 Mar 11; 2021 Mar 11. PMID: 33799820.", + "Imaging and optogenetic modulation of vascular mural cells in the live brain. Tong L, Hill RA, Damisah EC, Murray KN, Yuan P, Bordey A, Grutzendler J. Nat Protoc. 2021 Jan; 2020 Dec 9. PMID: 33299155.", + "Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice. Hsieh LS, Wen JH, Nguyen LH, Zhang L, Getz SA, Torres-Reveron J, Wang Y, Spencer DD, Bordey A. Sci Transl Med. 2020 Nov 18. PMID: 33208499.", + "Filamin A inhibition reduces seizure activity in a mouse model of focal cortical malformations. Zhang L, Huang T, Teaw S, Nguyen LH, Hsieh LS, Gong X, Burns LH, Bordey A. Sci Transl Med. 2020 Feb 19. PMID: 32075941.", + "GATORopathies: The role of amino acid regulatory gene mutations in epilepsy and cortical malformations. Iffland PH 2nd, Carson V, Bordey A, Crino PB. Epilepsia. 2019 Nov; 2019 Oct 17. PMID: 31625153.", + "Hypervascularization in mTOR-dependent focal and global cortical malformations displays differential rapamycin sensitivity. Zhang L, Huang T, Teaw S, Bordey A. Epilepsia. 2019 Jun; 2019 May 24. PMID: 31125447.", + "In utero electroporation-based translating ribosome affinity purification identifies age-dependent mRNA expression in cortical pyramidal neurons. Huang T, Nguyen LH, Lin TV, Gong X, Zhang L, Kim GB, Sarkisian MR, Breunig JJ, Bordey A. Neurosci Res. 2019 Jun; 2018 May 29. PMID: 29857015.", + "mTOR Hyperactivity Levels Influence the Severity of Epilepsy and Associated Neuropathology in an Experimental Model of Tuberous Sclerosis Complex and Focal Cortical Dysplasia. Nguyen LH, Mahadeo T, Bordey A. J Neurosci. 2019 Apr 3; 2019 Jan 30. PMID: 30700531.", + "Valnoctamide Inhibits Cytomegalovirus Infection in Developing Brain and Attenuates Neurobehavioral Dysfunctions and Brain Abnormalities. Ornaghi S, Hsieh LS, Bordey A, Vergani P, Paidas MJ, van den Pol AN. J Neurosci. 2017 Jul 19; 2017 Jun 19. PMID: 28630251.", + "Outbred CD1 mice are as suitable as inbred C57BL/6J mice in performing social tasks. Hsieh LS, Wen JH, Miyares L, Lombroso PJ, Bordey A. Neurosci Lett. 2017 Jan 10; 2016 Nov 18. PMID: 27871995.", + "Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP. Bartley CM, O'Keefe RA, Blice-Baum A, Mihailescu MR, Gong X, Miyares L, Karaca E, Bordey A. eNeuro. 2016 Nov-Dec; 2016 Nov 21. PMID: 27957526.", + "Normalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration. Lin TV, Hsieh L, Kimura T, Malone TJ, Bordey A. Proc Natl Acad Sci U S A. 2016 Oct 4; 2016 Sep 19. PMID: 27647922.", + "Tsc1 haploinsufficiency is sufficient to increase dendritic patterning and Filamin A levels. Zhang L, Huang T, Bordey A. Neurosci Lett. 2016 Aug 26; 2016 Jun 21. PMID: 27345385.", + "An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior. Jung Y, Hsieh LS, Lee AM, Zhou Z, Coman D, Heath CJ, Hyder F, Mineur YS, Yuan Q, Goldman D, Bordey A, Picciotto MR. Nat Neurosci. 2016 Jul; 2016 May 30. PMID: 27239938.", + "Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement. Hsieh LS, Wen JH, Claycomb K, Huang Y, Harrsch FA, Naegele JR, Hyder F, Buchanan GF, Bordey A. Nat Commun. 2016 Jun 1; 2016 Jun 1. PMID: 27249187.", + "The multifaceted subventricular zone astrocyte: From a metabolic and pro-neurogenic role to acting as a neural stem cell. Platel JC, Bordey A. Neuroscience. 2016 May 26; 2015 Nov 3. PMID: 26546469.", + "Switching on mTORC1 induces neurogenesis but not proliferation in neural stem cells of young mice. Mahoney C, Feliciano DM, Bordey A, Hartman NW. Neurosci Lett. 2016 Feb 12; 2016 Jan 23. PMID: 26812181.", + "Hypoxia-inducible factor-1a contributes to dendritic overgrowth in tuberous sclerosis. Zhang L, Feliciano DM, Huang T, Zhang S, Bordey A. Neurosci Lett. 2016 Jan 26; 2015 Dec 2. PMID: 26655465.", + "PreImplantation Factor bolsters neuroprotection via modulating Protein Kinase A and Protein Kinase C signaling. Mueller M, Schoeberlein A, Zhou J, Joerger-Messerli M, Oppliger B, Reinhart U, Bordey A, Surbek D, Barnea ER, Huang Y, Paidas M. Cell Death Differ. 2015 Dec; 2015 May 15. PMID: 25976303.", + "Activating the translational repressor 4E-BP or reducing S6K-GSK3β activity prevents accelerated axon growth induced by hyperactive mTOR in vivo. Gong X, Zhang L, Huang T, Lin TV, Miyares L, Wen J, Hsieh L, Bordey A. Hum Mol Genet. 2015 Oct 15; 2015 Jul 28. PMID: 26220974.", + "Noncanonical Sites of Adult Neurogenesis in the Mammalian Brain. Feliciano DM, Bordey A, Bonfanti L. Cold Spring Harb Perspect Biol. 2015 Sep 18; 2015 Sep 18. PMID: 26384869.", + "Voltage-dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells. Rela L, Piantanida AP, Bordey A, Greer CA. Glia. 2015 Sep; 2015 Apr 9. PMID: 25856239.", + "MEK-ERK1/2-dependent FLNA overexpression promotes abnormal dendritic patterning in tuberous sclerosis independent of mTOR. Zhang L, Bartley CM, Gong X, Hsieh LS, Lin TV, Feliciano DM, Bordey A. Neuron. 2014 Oct 1. PMID: 25277454.", + "Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model. Lozovaya N, Gataullina S, Tsintsadze T, Tsintsadze V, Pallesi-Pocachard E, Minlebaev M, Goriounova NA, Buhler E, Watrin F, Shityakov S, Becker AJ, Bordey A, Milh M, Scavarda D, Bulteau C, Dorfmuller G, Delalande O, Represa A, Cardoso C, Dulac O, Ben-Ari Y, Burnashev N. Nat Commun. 2014 Aug 1; 2014 Aug 1. PMID: 25081057.", + "FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity. Bartley CM, O'Keefe RA, Bordey A. PLoS One. 2014; 2014 May 7. PMID: 24806451.", + "Endogenous stem cells for enhancing cognition in the diseased brain. Bordey A. Front Neurosci. 2014; 2014 May 6. PMID: 24834025.", + "Elimination of gaseous microemboli from cardiopulmonary bypass using hypobaric oxygenation. Gipson KE, Rosinski DJ, Schonberger RB, Kubera C, Mathew ES, Nichols F, Dyckman W, Courtin F, Sherburne B, Bordey AF, Gross JB. Ann Thorac Surg. 2014 Mar; 2013 Nov 6. PMID: 24206970.", + "Embryonic cerebrospinal fluid nanovesicles carry evolutionarily conserved molecules and promote neural stem cell amplification. Feliciano DM, Zhang S, Nasrallah CM, Lisgo SN, Bordey A. PLoS One. 2014; 2014 Feb 12. PMID: 24533152.", + "GABAergic striatal neurons project dendrites and axons into the postnatal subventricular zone leading to calcium activity. Young SZ, Lafourcade CA, Platel JC, Lin TV, Bordey A. Front Cell Neurosci. 2014; 2014 Jan 28. PMID: 24478632.", + "BDNF promotes axon branching of retinal ganglion cells via miRNA-132 and p250GAP. Marler KJ, Suetterlin P, Dopplapudi A, Rubikaite A, Adnan J, Maiorano NA, Lowe AS, Thompson ID, Pathania M, Bordey A, Fulga T, Van Vactor DL, Hindges R, Drescher U. J Neurosci. 2014 Jan 15. PMID: 24431455.", + "A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits. Feliciano DM, Lin TV, Hartman NW, Bartley CM, Kubera C, Hsieh L, Lafourcade C, O'Keefe RA, Bordey A. Int J Dev Neurosci. 2013 Nov; 2013 Feb 26. PMID: 23485365.", + "mTORC1 targets the translational repressor 4E-BP2, but not S6 kinase 1/2, to regulate neural stem cell self-renewal in vivo. Hartman NW, Lin TV, Zhang L, Paquelet GE, Feliciano DM, Bordey A. Cell Rep. 2013 Oct 31; 2013 Oct 17. PMID: 24139800.", + "Hypoxia-inducible factor 1a is a Tsc1-regulated survival factor in newborn neurons in tuberous sclerosis complex. Feliciano DM, Zhang S, Quon JL, Bordey A. Hum Mol Genet. 2013 May 1; 2013 Jan 24. PMID: 23349360.", + "Neonatal subventricular zone electroporation. Feliciano DM, Lafourcade CA, Bordey A. J Vis Exp. 2013 Feb 11; 2013 Feb 11. PMID: 23426329.", + "Rheb activation in subventricular zone progenitors leads to heterotopia, ectopic neuronal differentiation, and rapamycin-sensitive olfactory micronodules and dendrite hypertrophy of newborn neurons. Lafourcade CA, Lin TV, Feliciano DM, Zhang L, Hsieh LS, Bordey A. J Neurosci. 2013 Feb 6. PMID: 23392671.", + "Newborn cortical neurons: only for neonates? Feliciano DM, Bordey A. Trends Neurosci. 2013 Jan; 2012 Oct 11. PMID: 23062965.", + "Neural progenitor cells regulate capillary blood flow in the postnatal subventricular zone. Lacar B, Herman P, Platel JC, Kubera C, Hyder F, Bordey A. J Neurosci. 2012 Nov 14. PMID: 23152626.", + "NKCC1 knockdown decreases neuron production through GABA(A)-regulated neural progenitor proliferation and delays dendrite development. Young SZ, Taylor MM, Wu S, Ikeda-Matsuo Y, Kubera C, Bordey A. J Neurosci. 2012 Sep 26. PMID: 23015452.", + "Preparation of acute subventricular zone slices for calcium imaging. Lacar B, Young SZ, Platel JC, Bordey A. J Vis Exp. 2012 Sep 19; 2012 Sep 19. PMID: 23023088.", + "Transient mGlu5R inhibition enhances the survival of granule cell precursors in the neonatal cerebellum. Kubera C, Hernandez AL, Heng V, Bordey A. Neuroscience. 2012 Sep 6; 2012 Jun 4. PMID: 22677205.", + "Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever! Ben-Ari Y, Woodin MA, Sernagor E, Cancedda L, Vinay L, Rivera C, Legendre P, Luhmann HJ, Bordey A, Wenner P, Fukuda A, van den Pol AN, Gaiarsa JL, Cherubini E. Front Cell Neurosci. 2012; 2012 Aug 28. PMID: 22973192.", + "Postnatal neurogenesis generates heterotopias, olfactory micronodules and cortical infiltration following single-cell Tsc1 deletion. Feliciano DM, Quon JL, Su T, Taylor MM, Bordey A. Hum Mol Genet. 2012 Feb 15; 2011 Nov 7. PMID: 22068588.", + "miR-132 enhances dendritic morphogenesis, spine density, synaptic integration, and survival of newborn olfactory bulb neurons. Pathania M, Torres-Reveron J, Yan L, Kimura T, Lin TV, Gordon V, Teng ZQ, Zhao X, Fulga TA, Van Vactor D, Bordey A. PLoS One. 2012; 2012 May 31. PMID: 22693596.", + "S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone. Lacar B, Herman P, Hartman NW, Hyder F, Bordey A. PLoS One. 2012; 2012 Feb 16. PMID: 22359646.", + "Gap junction-mediated calcium waves define communication networks among murine postnatal neural progenitor cells. Lacar B, Young SZ, Platel JC, Bordey A. Eur J Neurosci. 2011 Dec; 2011 Nov 18. PMID: 22098557.", + "Adult-born neuron development is controlled by GABAA receptor subtypes (Commentary on Duveau et al.). Bordey A. Eur J Neurosci. 2011 Aug. PMID: 21801241.", + "Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice. Feliciano DM, Su T, Lopez J, Platel JC, Bordey A. J Clin Invest. 2011 Apr; 2011 Mar 14. PMID: 21403402.", + "[Mouse model of tuberous sclerosis complex]. Feliciano D, Bordey A. Med Sci (Paris). 2011 Mar; 2011 Mar 30. PMID: 21447310.", + "Neurotransmitters couple brain activity to subventricular zone neurogenesis. Young SZ, Taylor MM, Bordey A. Eur J Neurosci. 2011 Mar. PMID: 21395856.", + "More neurons for respiratory adaptation: is neurogenesis at work? Bordey A. Respir Physiol Neurobiol. 2010 Sep 30; 2010 Aug 12. PMID: 20708724.", + "Prostaglandin E2 induces glutamate release from subventricular zone astrocytes. Dave KA, Platel JC, Huang F, Tian D, Stamboulian-Platel S, Bordey A. Neuron Glia Biol. 2010 Aug; 2011 Jan 7. PMID: 21211110.", + "[Function of NMDA receptors activated by astrocytic glutamate on postnatal neurogenesis]. Platel JC, Bordey A. Med Sci (Paris). 2010 Aug-Sep. PMID: 20819695.", + "Astroglial cells in the external granular layer are precursors of cerebellar granule neurons in neonates. Silbereis J, Heintz T, Taylor MM, Ganat Y, Ment LR, Bordey A, Vaccarino F. Mol Cell Neurosci. 2010 Aug; 2010 May 12. PMID: 20470892.", + "Imaging and recording subventricular zone progenitor cells in live tissue of postnatal mice. Lacar B, Young SZ, Platel JC, Bordey A. Front Neurosci. 2010; 2010 Jul 19. PMID: 20700392.", + "MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1. Smrt RD, Szulwach KE, Pfeiffer RL, Li X, Guo W, Pathania M, Teng ZQ, Luo Y, Peng J, Bordey A, Jin P, Zhao X. Stem Cells. 2010 Jun. PMID: 20506192.", + "Neurotransmitter signaling in postnatal neurogenesis: The first leg. Platel JC, Stamboulian S, Nguyen I, Bordey A. Brain Res Rev. 2010 May; 2010 Feb 24. PMID: 20188124.", + "The stem cell journey: from paradise to purgatory. Bordey A. Neuropharmacology. 2010 May; 2010 Feb 8. PMID: 20146927.", + "A symphony of signals conducts early and late stages of adult neurogenesis. Pathania M, Yan LD, Bordey A. Neuropharmacology. 2010 May; 2010 Jan 25. PMID: 20097213.", + "Olfactory ensheathing cell membrane properties are shaped by connectivity. Rela L, Bordey A, Greer CA. Glia. 2010 Apr 15. PMID: 19998494.", + "GABA(A) Increases Calcium in Subventricular Zone Astrocyte-Like Cells Through L- and T-Type Voltage-Gated Calcium Channels. Young SZ, Platel JC, Nielsen JV, Jensen NA, Bordey A. Front Cell Neurosci. 2010; 2010 Apr 8. PMID: 20422045.", + "NMDA receptors activated by subventricular zone astrocytic glutamate are critical for neuroblast survival prior to entering a synaptic network. Platel JC, Dave KA, Gordon V, Lacar B, Rubio ME, Bordey A. Neuron. 2010 Mar 25. PMID: 20346761.", + "Activation of adenosine A2B receptors enhances ciliary beat frequency in mouse lateral ventricle ependymal cells. Genzen JR, Yang D, Ravid K, Bordey A. Cerebrospinal Fluid Res. 2009 Nov 18; 2009 Nov 18. PMID: 19922651.", + "Ependymal cells along the lateral ventricle express functional P2X(7) receptors. Genzen JR, Platel JC, Rubio ME, Bordey A. Purinergic Signal. 2009 Sep; 2009 Mar 10. PMID: 19274488.", + "GABA's control of stem and cancer cell proliferation in adult neural and peripheral niches. Young SZ, Bordey A. Physiology (Bethesda). 2009 Jun. PMID: 19509127.", + "GABA increases Ca2+ in cerebellar granule cell precursors via depolarization: implications for proliferation. Dave KA, Bordey A. IUBMB Life. 2009 May. PMID: 19391160.", + "GFAP-GFP neural progenitors are antigenically homogeneous and anchored in their enclosed mosaic niche. Platel JC, Gordon V, Heintz T, Bordey A. Glia. 2009 Jan 1. PMID: 18661547.", + "The astrocyte odyssey. Wang DD, Bordey A. Prog Neurobiol. 2008 Dec 11; 2008 Oct 1. PMID: 18948166.", + "Tonic activation of GLUK5 kainate receptors decreases neuroblast migration in whole-mounts of the subventricular zone. Platel JC, Heintz T, Young S, Gordon V, Bordey A. J Physiol. 2008 Aug 15; 2008 Jun 19. PMID: 18565997.", + "Control of neuroblast production and migration by converging GABA and glutamate signals in the postnatal forebrain. Platel JC, Dave KA, Bordey A. J Physiol. 2008 Aug 15; 2008 May 8. PMID: 18467361.", + "GABAA receptors, anesthetics and anticonvulsants in brain development. Henschel O, Gipson KE, Bordey A. CNS Neurol Disord Drug Targets. 2008 Apr. PMID: 18537647.", + "GABA and glutamate signaling: homeostatic control of adult forebrain neurogenesis. Platel JC, Lacar B, Bordey A. J Mol Histol. 2007 Dec. PMID: 18309566.", + "GABA and glutamate signaling: homeostatic control of adult forebrain neurogenesis. Platel JC, Lacar B, Bordey A. J Mol Histol. 2007 Aug; 2007 Jun 7. PMID: 17554632.", + "", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Braddock Lab", + "lab_url": "https://medicine.yale.edu/lab/braddock/", + "research_bio": "INFORMATION FOR The Braddock lab studies diseases associated with enzyme deficiencies, focusing on severe unmet medical illness in the pediatric population. We employ murine models, protein engineering and design, and an array of biochemical, molecular biologic, and biophysical methods to define disease pathogenesis and develop novel therapeutics. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/braddock/publications", + "publications": [ + "Yale School of Medicine /", + "Pathology /", + "Research", + "Intellectual Property", + "People", + "Connect with Us", + "Publications", + "News", + "Clinical Trials", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "Clinical Trials", + "Intellectual Property", + "Connect with Us", + "News", + "", + "", + "", + "", + "", + "", + "The prevalence of ENPP1 deficiency in humans with OPLL and the preclinical efficacy of ENPP1 enzyme therapy in OPLL mice. Srivastava S, Kato H, von Kroge S, Weise K, Stabach P, Lopez SG, O'Brien K, Lester ER, Kim H, Ishaq T, Dammen-Brower K, Schinke T, Kimura S, Miyahara J, Doi T, Oshima Y, Yarema KJ, Carpenter TO, Sabbagh Y, Tommasini SM, Ito N, Oheim R, Braddock DT. J Bone Miner Res. 2025 Nov 18; 2025 Nov 18. PMID: 41251406.", + "Kinetic mechanism of ENPP1 ATPase: Implications for aberrant calcification disorders and enzyme replacement therapy. Michalchik MM, Potchernikov T, Lester ER, Braddock DT, Cao W, De La Cruz EM. J Biol Chem. 2025 Sep; 2025 Aug 5. PMID: 40769408.", + "Improvements in hearing loss with bone-targeted enzyme replacement therapy are associated with corrected hypomineralization and osteocyte properties of auditory ossicles in Enpp1-deficient mice. Ocokoljic A, Srivastava S, von Kroge S, Stabach PR, Busse B, Weise K, Oheim R, Rolvien T, Braddock DT. J Bone Miner Res. 2025 Aug 24. PMID: 40495691.", + "Novel treatment for PXE: Recombinant ENPP1 enzyme therapy. Jacobs IJ, Obiri-Yeboah D, Stabach PR, Braddock DT, Li Q. Mol Ther. 2024 Nov 6; 2024 Sep 27. PMID: 39342427.", + "Effect of Mutation Type on Ectopic Ossification Among Adult Patients With X-Linked Hypophosphatemia. Kato H, Ishihara Y, Ohata Y, Irie K, Watanabe S, Kimura S, Hoshino Y, Hidaka N, Kinoshita Y, Taniguchi Y, Kobayashi H, Braddock DT, Kubota T, Ozono K, Nangaku M, Makita N, Ito N. J Endocr Soc. 2024 Oct 29; 2024 Oct 22. PMID: 39498416.", + "Quantitative correlation of ENPP1 pathogenic variants with disease phenotype. Ansh AJ, Stabach PR, Ciccone C, Cao W, De La Cruz EM, Sabbagh Y, Carpenter TO, Ferreira CR, Braddock DT. Bone. 2024 Sep; 2024 May 26. PMID: 38806089.", + "A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models. Stabach PR, Sims D, Gomez-Bañuelos E, Zehentmeier S, Dammen-Brower K, Bernhisel A, Kujawski S, Lopez SG, Petri M, Goldman DW, Lester ER, Le Q, Ishaq T, Kim H, Srivastava S, Kumar D, Pereira JP, Yarema KJ, Koumpouras F, Andrade F, Braddock DT. JCI Insight. 2024 Jun 18; 2024 Jun 18. PMID: 38888971.", + "ENPP1 in Blood and Bone: Skeletal and Soft Tissue Diseases Induced by ENPP1 Deficiency. Ferreira CR, Carpenter TO, Braddock DT. Annu Rev Pathol. 2024 Jan 24; 2023 Oct 23. PMID: 37871131.", + "Genetics of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of the Spinal Ligaments. Kato H, Braddock DT, Ito N. Curr Osteoporos Rep. 2023 Oct; 2023 Aug 2. PMID: 37530996.", + "Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome. Murtada SI, Mikush N, Wang M, Ren P, Kawamura Y, Ramachandra AB, Li DS, Braddock DT, Tellides G, Gordon LB, Humphrey JD. Elife. 2023 Mar 17; 2023 Mar 17. PMID: 36930696.", + "Catalysis-Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass. Zimmerman K, Liu X, von Kroge S, Stabach P, Lester ER, Chu EY, Srivastava S, Somerman MJ, Tommasini SM, Busse B, Schinke T, Carpenter TO, Oheim R, Braddock DT. J Bone Miner Res. 2022 Sep; 2022 Jul 29. PMID: 35773783.", + "Characterization of hearing-impairment in Generalized Arterial Calcification of Infancy (GACI). Theng EH, Brewer CC, Oheim R, Zalewski CK, King KA, Delsmann MM, Rolvien T, Gafni RI, Braddock DT, Jeffrey Kim H, Ferreira CR. Orphanet J Rare Dis. 2022 Jul 19; 2022 Jul 19. PMID: 35854274.", + "Identification of ENPP1 Haploinsufficiency in Patients With Diffuse Idiopathic Skeletal Hyperostosis and Early-Onset Osteoporosis. Kato H, Ansh AJ, Lester ER, Kinoshita Y, Hidaka N, Hoshino Y, Koga M, Taniguchi Y, Uchida T, Yamaguchi H, Niida Y, Nakazato M, Nangaku M, Makita N, Takamura T, Saito T, Braddock DT, Ito N. J Bone Miner Res. 2022 Jun; 2022 Apr 11. PMID: 35340077.", + "Strategies for Glycoengineering Therapeutic Proteins. Dammen-Brower K, Epler P, Zhu S, Bernstein ZJ, Stabach PR, Braddock DT, Spangler JB, Yarema KJ. Front Chem. 2022; 2022 Apr 13. PMID: 35494652.", + "Musculoskeletal Comorbidities and Quality of Life in ENPP1-Deficient Adults and the Response of Enthesopathy to Enzyme Replacement Therapy in Murine Models. Ferreira CR, Ansh AJ, Nester C, O'Brien C, Stabach PR, Murtada SI, Lester ER, Khursigara G, Molloy L, Carpenter TO, Braddock DT. J Bone Miner Res. 2022 Mar; 2021 Dec 26. PMID: 34882836.", + "Direct targeting of amplified gene loci for proapoptotic anticancer therapy. Kaushik Tiwari M, Colon-Rios DA, Tumu HCR, Liu Y, Quijano E, Krysztofiak A, Chan C, Song E, Braddock DT, Suh HW, Saltzman WM, Rogers FA. Nat Biotechnol. 2022 Mar; 2021 Oct 28. PMID: 34711990.", + "Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair. Li S, Yokota T, Wang P, Ten Hoeve J, Ma F, Le TM, Abt ER, Zhou Y, Wu R, Nanthavongdouangsy M, Rodriguez A, Wang Y, Lin YJ, Muranaka H, Sharpley M, Braddock DT, MacRae VE, Banerjee U, Chiou PY, Seldin M, Huang D, Teitell M, Gertsman I, Jung M, Bensinger SJ, Damoiseaux R, Faull K, Pellegrini M, Lusis AJ, Graeber TG, Radu CG, Deb A. J Clin Invest. 2022 Jan 18. PMID: 34813507.", + "Response of the ENPP1-Deficient Skeletal Phenotype to Oral Phosphate Supplementation and/or Enzyme Replacement Therapy: Comparative Studies in Humans and Mice. Ferreira CR, Kavanagh D, Oheim R, Zimmerman K, Stürznickel J, Li X, Stabach P, Rettig RL, Calderone L, MacKichan C, Wang A, Hutchinson HA, Nelson T, Tommasini SM, von Kroge S, Fiedler IA, Lester ER, Moeckel GW, Busse B, Schinke T, Carpenter TO, Levine MA, Horowitz MC, Braddock DT. J Bone Miner Res. 2021 May; 2021 Feb 18. PMID: 33465815.", + "Improving the Pharmacodynamics and In Vivo Activity of ENPP1-Fc Through Protein and Glycosylation Engineering. Stabach PR, Zimmerman K, Adame A, Kavanagh D, Saeui CT, Agatemor C, Gray S, Cao W, De La Cruz EM, Yarema KJ, Braddock DT. Clin Transl Sci. 2021 Jan; 2020 Oct 20. PMID: 33064927.", + "Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization. Maulding ND, Kavanagh D, Zimmerman K, Coppola G, Carpenter TO, Jue NK, Braddock DT. Bone. 2021 Jan; 2020 Sep 24. PMID: 32980560.", + "Phylogeny and chemistry of biological mineral transport. Schlesinger PH, Braddock DT, Larrouture QC, Ray EC, Riazanski V, Nelson DJ, Tourkova IL, Blair HC. Bone. 2020 Dec; 2020 Aug 26. PMID: 32858255.", + "Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Hsiao HT, Crichlow GV, Murphy JW, Folta-Stogniew EJ, Lolis EJ, Braddock DT. PLoS One. 2020; 2020 Nov 30. PMID: 33253191.", + "Next generation miRNA inhibition using short anti-seed PNAs encapsulated in PLGA nanoparticles. Malik S, Lim J, Slack FJ, Braddock DT, Bahal R. J Control Release. 2020 Nov 10; 2020 Aug 21. PMID: 32835710.", + "Genetic and pharmacologic modulation of cementogenesis via pyrophosphate regulators. Chu EY, Vo TD, Chavez MB, Nagasaki A, Mertz EL, Nociti FH, Aitken SF, Kavanagh D, Zimmerman K, Li X, Stabach PR, Braddock DT, Millán JL, Foster BL, Somerman MJ. Bone. 2020 Jul; 2020 Mar 26. PMID: 32224162.", + "Paradoxical aortic stiffening and subsequent cardiac dysfunction in Hutchinson-Gilford progeria syndrome. Murtada SI, Kawamura Y, Caulk AW, Ahmadzadeh H, Mikush N, Zimmerman K, Kavanagh D, Weiss D, Latorre M, Zhuang ZW, Shadel GS, Braddock DT, Humphrey JD. J R Soc Interface. 2020 May; 2020 May 27. PMID: 32453981.", + "Clinical and Biochemical Phenotypes in a Family With ENPP1 Mutations. Kotwal A, Ferrer A, Kumar R, Singh RJ, Murthy V, Schultz-Rogers L, Zimmermann M, Lanpher B, Zimmerman K, Stabach PR, Klee E, Braddock DT, Wermers RA. J Bone Miner Res. 2020 Apr; 2020 Jan 16. PMID: 31826312.", + "Human Heterozygous ENPP1 Deficiency Is Associated With Early Onset Osteoporosis, a Phenotype Recapitulated in a Mouse Model of Enpp1 Deficiency. Oheim R, Zimmerman K, Maulding ND, Stürznickel J, von Kroge S, Kavanagh D, Stabach PR, Kornak U, Tommasini SM, Horowitz MC, Amling M, Thompson D, Schinke T, Busse B, Carpenter TO, Braddock DT. J Bone Miner Res. 2020 Mar; 2019 Dec 5. PMID: 31805212.", + "Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome. Gordon CM, Cleveland RH, Baltrusaitis K, Massaro J, D'Agostino RB Sr, Liang MG, Snyder B, Walters M, Li X, Braddock DT, Kleinman ME, Kieran MW, Gordon LB. Bone. 2019 Aug; 2019 May 8. PMID: 31077852.", + "Intraperitoneal pyrophosphate treatment reduces renal calcifications in Npt2a null mice. Caballero D, Li Y, Fetene J, Ponsetto J, Chen A, Zhu C, Braddock DT, Bergwitz C. PLoS One. 2017; 2017 Jul 13. PMID: 28704395.", + "In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery. Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, López-Giráldez F, Ricciardi A, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Mark Saltzman W, Ly DH, Glazer PM. Nat Commun. 2016 Oct 26; 2016 Oct 26. PMID: 27782131.", + "ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy. Albright RA, Stabach P, Cao W, Kavanagh D, Mullen I, Braddock AA, Covo MS, Tehan M, Yang G, Cheng Z, Bouchard K, Yu ZX, Thorn S, Wang X, Folta-Stogniew EJ, Negrete A, Sinusas AJ, Shiloach J, Zubal G, Madri JA, De La Cruz EM, Braddock DT. Nat Commun. 2015 Dec 1; 2015 Dec 1. PMID: 26624227.", + "MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, Slack FJ. Nature. 2015 Feb 5; 2014 Nov 17. PMID: 25409146.", + "Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Madiraju AK, Erion DM, Rahimi Y, Zhang XM, Braddock DT, Albright RA, Prigaro BJ, Wood JL, Bhanot S, MacDonald MJ, Jurczak MJ, Camporez JP, Lee HY, Cline GW, Samuel VT, Kibbey RG, Shulman GI. Nature. 2014 Jun 26; 2014 May 21. PMID: 24847880.", + "Molecular basis of purinergic signal metabolism by ectonucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke. Albright RA, Ornstein DL, Cao W, Chang WC, Robert D, Tehan M, Hoyer D, Liu L, Stabach P, Yang G, De La Cruz EM, Braddock DT. J Biol Chem. 2014 Feb 7; 2013 Dec 12. PMID: 24338010.", + "Desmoplastic melanoma: a 12-year experience with sentinel lymph node biopsy. Broer PN, Walker ME, Goldberg C, Buonocore S, Braddock DT, Lazova R, Narayan D, Ariyan S. Eur J Surg Oncol. 2013 Jul; 2013 Mar 22. PMID: 23522951.", + "NPP4 is a procoagulant enzyme on the surface of vascular endothelium. Albright RA, Chang WC, Robert D, Ornstein DL, Cao W, Liu L, Redick ME, Young JI, De La Cruz EM, Braddock DT. Blood. 2012 Nov 22; 2012 Sep 20. PMID: 22995898.", + "Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution. Saunders LP, Cao W, Chang WC, Albright RA, Braddock DT, De La Cruz EM. J Biol Chem. 2011 Aug 26; 2011 Jun 30. PMID: 21719699.", + "Quantitative characterization of the interactions among c-myc transcriptional regulators FUSE, FBP, and FIR. Hsiao HH, Nath A, Lin CY, Folta-Stogniew EJ, Rhoades E, Braddock DT. Biochemistry. 2010 Jun 8. PMID: 20420426.", + "Autotaxin and lipid signaling pathways as anticancer targets. Braddock DT. Curr Opin Investig Drugs. 2010 Jun. PMID: 20496257.", + "Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion. Saunders LP, Ouellette A, Bandle R, Chang WC, Zhou H, Misra RN, De La Cruz EM, Braddock DT. Mol Cancer Ther. 2008 Oct. PMID: 18852138.", + "Histopathologic and molecular aspects of CD56+ natural killer/ T-cell lymphoma of the testis. Ornstein DL, Bifulco CB, Braddock DT, Howe JG. Int J Surg Pathol. 2008 Jul. PMID: 18573785.", + "NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter. Huth JR, Yu L, Collins I, Mack J, Mendoza R, Isaac B, Braddock DT, Muchmore SW, Comess KM, Fesik SW, Clore GM, Levens D, Hajduk PJ. J Med Chem. 2004 Sep 23. PMID: 15369388.", + "Molecular basis of sequence-specific single-stranded DNA recognition by KH domains: solution structure of a complex between hnRNP K KH3 and single-stranded DNA. Braddock DT, Baber JL, Levens D, Clore GM. EMBO J. 2002 Jul 1. PMID: 12093748.", + "Structure and dynamics of KH domains from FBP bound to single-stranded DNA. Braddock DT, Louis JM, Baber JL, Levens D, Clore GM. Nature. 2002 Feb 28. PMID: 11875576.", + "Rapid identification of medium- to large-scale interdomain motion in modular proteins using dipolar couplings. Braddock DT, Cai M, Baber JL, Huang Y, Clore GM. J Am Chem Soc. 2001 Sep 5. PMID: 11525687.", + "Biophysical characterization of gp41 aggregates suggests a model for the molecular mechanism of HIV-associated neurological damage and dementia. Caffrey M, Braddock DT, Louis JM, Abu-Asab MA, Kingma D, Liotta L, Tsokos M, Tresser N, Pannell LK, Watts N, Steven AC, Simon MN, Stahl SJ, Wingfield PT, Clore GM. J Biol Chem. 2000 Jun 30. PMID: 10747981.", + "Treatment of autoimmune premature ovarian failure. Kalantaridou SN, Braddock DT, Patronas NJ, Nelson LM. Hum Reprod. 1999 Jul. PMID: 10402388.", + "Structure-function relationships in side chain lactam cross-linked peptide models of a conserved N-terminal domain of apolipoprotein E. Benzinger TL, Braddock DT, Dominguez SR, Burkoth TS, Miller-Auer H, Subramanian RM, Fless GM, Jones DN, Lynn DG, Meredith SC. Biochemistry. 1998 Sep 22. PMID: 9748329.", + "Conformationally specific enhancement of receptor-mediated LDL binding and internalization by peptide models of a conserved anionic N-terminal domain of human apolipoprotein E. Braddock DT, Mercurius KO, Subramanian RM, Dominguez SR, Davies PF, Meredith SC. Biochemistry. 1996 Nov 5. PMID: 8909295.", + "Structural and thermodynamic characterization of a bioactive peptide model of apolipoprotein E: side-chain lactam bridges to constrain the conformation. Luo P, Braddock DT, Subramanian RM, Meredith SC, Lynn DG. Biochemistry. 1994 Oct 18. PMID: 7918459.", + "Braddock Lab 310 Cedar Street PO Box 208023 New Haven, CT 06520-8023", + "1 Event you could attend in November 2025 Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Brain Energy Atlas Project", + "lab_url": "https://medicine.yale.edu/lab/brain-energy-atlas/", + "research_bio": "INFORMATION FOR The goal of this project, a collaboration between Yale University and Fudan University, is to create the next generation of neuroscientific tools for highly detailed human brain spatial reference systems of energy metabolism - derived purely on basis of neuropil density throughout health and disease. A 3D energy map, derived in silico, represents an important step to fundamentally advance the field of functional neuroimaging by facilitating the understanding and quantification of microscopic anatomy underlying macroscopic measures of brain function. This project is a collaboration between Yale University and Fudan University.It has been supported by National Institute of Health of USA (R01 NS-100106) and Natural Science Foundation of China (81761128011).", + "publications_page": "https://medicine.yale.edu/lab/brain-energy-atlas/publications", + "publications": [ + "Yale School of Medicine /", + "Radiology & Biomedical Imaging /", + "About", + "Contact", + "Maps Agreement License", + "Agreement", + "License", + "Tools Software Agreement Policy Software License", + "Software Agreement Policy", + "Software License", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "About", + "Maps", + "Tools", + "Publications", + "Contact", + "", + "", + "", + "", + "", + "", + "Hyder F et al (2013) PNAS USA", + "Yu Y et al (2018) J Cereb Blood Flow Metab", + "Mortensen KN et al (2018) Neural Plasticity", + "Yu Y et al (2022) Cerebral Cortex", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Breast Medical Oncology Group", + "lab_url": "https://medicine.yale.edu/lab/pusztai/", + "research_bio": "INFORMATION FOR The Breast Medical Oncology group is a multidisciplinary team including clinicians, laboratory scientists, bioinformaticians and students. We provide state-of the art clinical care and conduct research including therapeutic clinical trials, genomic analysis of cancer and new drug development in the laboratory. Our Bioinformatics team is developing new tools for clinical outcome prediction and genome analysis. Tel 203-737-8309, Fax: 203-785-5792. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/pusztai/publications/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Medical Oncology and Hematology /", + "People", + "Events", + "Contact", + "Clinical Trials Archive ER/PR(+) HER2 TNBC DCIS Molecular Profiling", + "Archive ER/PR(+) HER2 TNBC DCIS Molecular Profiling", + "ER/PR(+)", + "HER2", + "TNBC", + "DCIS", + "Molecular Profiling", + "Intranet", + "Publications", + "TICER User Guide Theoretical Basis", + "User Guide", + "Theoretical Basis", + "News Media", + "Media", + "Resources", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "People", + "Clinical Trials", + "Publications", + "News", + "Events", + "Intranet", + "TICER", + "Resources", + "Contact", + "", + "", + "", + "", + "", + "", + "Integrating large-scale in vitro functional genomic screen and multi-omics data to identify novel breast cancer targets. Lin HK, Dai J, Pusztai L. Breast Cancer Res Treat. 2025 Dec; 2025 Sep 1. PMID: 40888991.", + "Mixed Molecular Subtypes Coexist in Estrogen Receptor Heterogeneous Primary Breast Cancers. Foldi J, Xiong K, Liu M, Robbins CJ, Chen F, Zhan H, Burela S, Dai J, Karn PL, Dugo M, Bianchini G, Lee AV, Oesterreich S, Rimm DL, Pusztai L. JCO Precis Oncol. 2025 Nov; 2025 Nov 14. PMID: 41237360.", + "Neoadjuvant trastuzumab deruxtecan alone or followed by paclitaxel, trastuzumab, and pertuzumab for high-risk HER2-positive early breast cancer (DESTINY-Breast11): a randomised, open-label, multicentre, phase 3 trial. Harbeck N, Modi S, Pusztai L, Ohno S, Wu J, Kim SB, Yoshida A, Fabi A, Cao X, Joseph R, Li R, Żurawski B, Escrivá-de-Romaní S, Meneguetti R, Supavavej A, Chen SC, Liu Z, Kelly C, Curigliano G, Symmans WF, Gufran M, Ke J, Konpa A, Herbolsheimer P, Boileau JF. Ann Oncol. 2025 Oct 18; 2025 Oct 18. PMID: 41130363.", + "Plain language summary of publication: Comparing nivolumab and neoadjuvant chemotherapy with placebo and neoadjuvant chemotherapy in participants with newly diagnosed estrogen receptor-positive breast cancer in the CheckMate 7FL clinical trial. Loi S, Salgado R, Curigliano G, Iván Romero Díaz R, Delaloge S, Rojas García CI, Kok M, Saura C, Harbeck N, Mittendorf EA, Yardley DA, Suárez Zaizar A, Caminos FR, Ungureanu A, Reinoso-Toledo JG, Guarneri V, Egle D, Ades F, Pacius M, Chhibber A, Chandra R, Nathani R, Spires T, Qun Wu J, Pusztai L, McArthur H. Future Oncol. 2025 Oct; 2025 Oct 7. PMID: 41058157.", + "Tumor-specific major histocompatibility-II expression predicts pathological complete response to atezolizumab combined to chemotherapy in triple-negative breast cancer. Balko JM, Licata L, Wang XQ, Dugo M, Huang CS, Egle D, Bermejo B, Zamagni C, Thill M, Anton A, Russo S, Sevillano E, Ciruelos EM, Greil R, Semiglazov V, Colleoni M, Kelly CM, Mariani G, Del Mastro L, Zambelli S, Viale G, Callari M, Viale G, Pusztai L, Gianni L, Ali HR, Bianchini G. NPJ Breast Cancer. 2025 Sep 29; 2025 Sep 29. PMID: 41022779.", + "Correction: Associations amongst genes, molecules, cells, and organs in breast cancer metastasis. Nathanson SD, Dieterich LC, Zhang XH, Chitale DA, Pusztai L, Reynaud E, Wu YH, Ríos-Hoyo A. Clin Exp Metastasis. 2025 Sep 19; 2025 Sep 19. PMID: 40970985.", + "Timing of Recurrence after Neoadjuvant Chemo-Immunotherapy in Patients with Early-Stage Triple-Negative Breast Cancer. Licata L, Mariani M, Viale G, Dent R, Tolaney SM, Schmid P, Hamilton E, Sotiriou C, Pusztai L, Bianchini G. Clin Cancer Res. 2025 Sep 15. PMID: 40689866.", + "Inhibition of MCL-1 and MEK Overcomes MEK Inhibitor Resistance in Triple-Negative and Inflammatory Breast Cancers. Mughees M, Tacam M, Tan AW, Pitner MK, Iles LR, Hu X, Villodre ES, Debeb BG, Kogawa T, Lim B, Layman RM, Woodward WA, Ueno NT, Tripathy D, Krishnamurthy S, Qi Y, Pusztai L, Wang J, Gandhi V, Bartholomeusz G, Bartholomeusz C. Mol Cancer Ther. 2025 Sep 2. PMID: 40358476.", + "Integration of Gene Expression and Digital Histology to Predict Treatment-Specific Responses in Breast Cancer. Howard FM, Dolezal J, Hieromnimon H, Venters S, Kochanny S, Li A, Borowsky A, Symmans WF, Wolf D, Brown-Swigart L, Sun A, Basu A, Hirst G, Nguyen LC, Asare A, Kanaparthi S, Khramtsova G, Blenman K, Shan NL, Fan C, Tolaney SM, Somlo G, Hudis CA, Sikov W, McCart L, Watson M, Carey L, Stover DG, Veer LV, Esserman LJ, Perou CM, Pusztai L, Olopade OI, Huo D, Nanda R, Pearson AT. medRxiv. 2025 Aug 27; 2025 Aug 27. PMID: 40909848.", + "Erratum: De Novo Oligometastatic Breast Cancer. Pusztai L, Rozenblit M, Dubsky P, Bachelot T, Kirby AM, Linderholm BK, White JR, Chmura SJ, Carey LA, Chua BH, Miller KD. J Clin Oncol. 2025 Aug 20; 2025 Jul 21. PMID: 40690726.", + "Immune Subtyping Identifies Patients With Hormone Receptor-Positive Early-Stage Breast Cancer Who Respond to Neoadjuvant Immunotherapy (IO): Results From Five IO Arms of the I-SPY2 Trial. Wolf DM, Yau C, Campbell M, Glas A, Barcaru A, Mittempergher L, Kuilman M, Brown-Swigart L, Hirst G, Basu A, Magbanua M, Sayaman R, Huppert L, Delson A, Symmans WF, Borowsky A, Pohlmann P, Rugo H, Clark A, Yee D, DeMichele A, Perlmutter J, Petricoin EF, Chien J, Stringer-Reasor E, Shatsky R, Liu M, Han H, Soliman H, Isaacs C, Nanda R, Hylton N, Pusztai L, Esserman L, van 't Veer L. JCO Precis Oncol. 2025 Jun; 2025 Jun 17. PMID: 40526879.", + "Clinical factors influencing retreatment with anti-PD-(L)1 therapies after treatment in early-stage cancers: a modified Delphi consensus study. Pusztai L, Sondak VK, Aguiar-Ibáñez R, Cappuzzo F, Chouaid C, Elder C, Hirasawa Y, Ishida M, Jones R, Lee SH, Mizuno R, Nagata M, Okonji D, Parente P, Shah B, Sun A, Ferreira D, Spiteri C, Lauer A, Kaliasethi A, Kao C, Kothari S, McKendrick J. J Immunother Cancer. 2025 May 26; 2025 May 26. PMID: 40425232.", + "Dynamic clustering of genomics cohorts beyond race, ethnicity-and ancestry. Mohsen H, Blenman K, Emani PS, Morris Q, Carrot-Zhang J, Pusztai L. BMC Med Genomics. 2025 May 15; 2025 May 15. PMID: 40375077.", + "A comprehensive evaluation of diversity measures for TCR repertoire profiling. Mika J, Polanska A, Blenman KR, Pusztai L, Polanska J, Candéias S, Marczyk M. BMC Biol. 2025 May 14; 2025 May 14. PMID: 40369611.", + "Genomic landscape and homologous recombination repair deficiency signature in stage I-III and de novo stage IV primary breast cancers. Jeon JE, Chen KT, Madison R, Schrock AB, Sokol E, Levy MA, Rozenblit M, Huang RSP, Pusztai L. Oncologist. 2025 May 8. PMID: 40421962.", + "Breastfeeding attributable fraction of triple negative breast cancer in the US. Chehayeb RJ, Odzer N, Albany RA, Ferrucci L, Sarpong D, Perez-Escamilla R, Lewis JB, Phipps AI, Meisner A, Pusztai L. NPJ Breast Cancer. 2025 May 7; 2025 May 7. PMID: 40328734.", + "Race and clinical outcomes in hormone receptor-positive, HER2-negative, node-positive breast cancer in the randomized RxPONDER trial. Abdou Y, Barlow WE, Gralow JR, Meric-Bernstam F, Albain KS, Hayes DF, Lin NU, Perez EA, Goldstein LJ, Chia SKL, Dhesy-Thind S, Rastogi P, Alba E, Delaloge S, Schott AF, Shak S, Sharma P, Lew DL, Miao J, Unger JM, Tripathy D, Hortobagyi GN, Pusztai L, Kalinsky K. J Natl Cancer Inst. 2025 May 1. PMID: 39656951.", + "Clinical Management of Ovarian Function Suppression in Premenopausal Women With Breast Cancer: A Survey of Members of ASCO. Kelly CM, Bennett KE, Cahir C, Eisen A, Pusztai L. JCO Oncol Pract. 2025 May; 2024 Nov 12. PMID: 39531598.", + "Genomic alterations in normal breast tissues preceding breast cancer diagnosis. Dai J, Rozenblit M, Li X, Shan NL, Wang Y, Mane S, Marczyk M, Pusztai L. Breast Cancer Res. 2025 Apr 22; 2025 Apr 22. PMID: 40264151.", + "Development and Validation of the RSClinN+ Tool to Predict Prognosis and Chemotherapy Benefit for Hormone Receptor-Positive, Node-Positive Breast Cancer. Pusztai L, Hoag JR, Albain KS, Barlow WE, Stemmer SM, Meisner A, Hortobagyi GN, Shak S, Rae JM, Baehner R, Sharma P, Kalinsky KM. J Clin Oncol. 2025 Mar 10; 2024 Dec 2. PMID: 39621968.", + "Determinants of response and molecular dynamics in HER2+ER+ breast cancers from the NA-PHER2 trial receiving HER2-targeted and endocrine therapies. Callari M, Dugo M, Barreca M, Győrffy B, Galbardi B, Vigano L, Locatelli A, Dall'Ara C, Ferrarini M, Bisagni G, Colleoni M, Mansutti M, Zamagni C, Del Mastro L, Zambelli S, Frassoldati A, Biasi O, Pusztai L, Valagussa P, Viale G, Gianni L, Bianchini G. Nat Commun. 2025 Mar 4; 2025 Mar 4. PMID: 40038334.", + "Comparative analysis of Ficoll-Hypaque and CytoLyt techniques for blood removal in breast cancer malignant effusions: effects on RNA quality and sequencing outcomes. Sura GH, Tran K, Trevarton AJ, Marczyk M, Fu C, Du L, Qu J, Lau R, Tasto A, Gould RE, Tinnirello A, Sinn BV, Pusztai L, Hatzis C, Symmans WF. J Am Soc Cytopathol. 2025 Mar-Apr; 2024 Nov 15. PMID: 39668068.", + "A pooled analysis evaluating prognostic significance of Residual Cancer Burden in invasive lobular breast cancer. Mukhtar RA, Gottipati S, Yau C, López-Tarruella S, Earl H, Hayward L, Hiller L, Osdoit M, van der Noordaa M, de Croze D, Hamy AS, Laé M, Reyal F, Sonke GS, Steenbruggen TG, van Seijen M, Wesseling J, Martín M, Del Monte-Millán M, Boughey JC, Goetz MP, Hoskin T, Valero V, Edge SB, Abraham JE, Bartlett JMS, Caldas C, Dunn J, Provenzano E, Sammut SJ, Thomas JS, Graham A, Hall P, Mackintosh L, Fan F, Godwin AK, Schwensen K, Sharma P, DeMichele AM, Cole K, Pusztai L, Kim MO, J van 't Veer L, Cameron D, Esserman LJ, Fraser Symmans W. NPJ Breast Cancer. 2025 Feb 13; 2025 Feb 13. PMID: 39948079.", + "Neoadjuvant nivolumab and chemotherapy in early estrogen receptor-positive breast cancer: a randomized phase 3 trial. Loi S, Salgado R, Curigliano G, Romero Díaz RI, Delaloge S, Rojas García CI, Kok M, Saura C, Harbeck N, Mittendorf EA, Yardley DA, Suárez Zaizar A, Caminos FR, Ungureanu A, Reinoso-Toledo JG, Guarneri V, Egle D, Ades F, Pacius M, Chhibber A, Chandra R, Nathani R, Spires T, Wu JQ, Pusztai L, McArthur H. Nat Med. 2025 Feb; 2025 Jan 21. PMID: 39838118.", + "Trends in breast cancer-specific death by clinical stage at diagnoses between 2000 and 2017. Marczyk M, Kahn A, Silber A, Rosenblit M, Digiovanna MP, Lustberg M, Pusztai L. J Natl Cancer Inst. 2025 Feb 1. PMID: 39348186.", + "Hormone Receptor-Positive HER2-Negative/MammaPrint High-2 Breast Cancers Closely Resemble Triple-Negative Breast Cancers. Rios-Hoyo A, Xiong K, Dai J, Yau C, Marczyk M, Garcia-Milian R, Wolf DM, Huppert LA, Nanda R, Hirst GL, Cobain EF, van 't Veer LJ, Esserman LJ, Pusztai L. Clin Cancer Res. 2025 Jan 17. PMID: 39561272.", + "GABA(A) receptor π forms channels that stimulate ERK through a G-protein-dependent pathway. Wang Y, Zhang Y, Li W, Salovska B, Zhang J, Li T, Li H, Liu Y, Kaczmarek LK, Pusztai L, Klein DE. Mol Cell. 2025 Jan 2; 2024 Dec 5. PMID: 39642883.", + "Clinical Implications of Breast Cancer Intrinsic Subtypes. Rios-Hoyo A, Shan NL, Karn PL, Pusztai L. Adv Exp Med Biol. 2025. PMID: 39821037.", + "Rare germline variants in cancer-relevant genes are associated with breast cancer risk in young women with high-risk family history. Rozenblit M, Qing T, Ye Y, Zhao H, Hofstatter E, Singh V, Reisenbichler E, Murray M, Pusztai L. Breast Cancer Res Treat. 2025 Jan; 2024 Nov 27. PMID: 39602012.", + "Molecular characteristics of advanced colorectal cancer and multi-hit PIK3CA mutations. Yasin F, Sokol E, Vasan N, Pavlick DC, Huang RSP, Pelletier M, Levy MA, Pusztai L, Lacy J, Zhang JY, Ross JS, Cecchini M. Oncologist. 2024 Dec 6. PMID: 39401325.", + "Circulating tumor DNA fraction predicts residual cancer burden post-neoadjuvant chemotherapy in triple negative breast cancer. Shan NL, Gould B, Wang X, Bonora G, Blenman K, Foldi J, Campos GE, Walsh M, Du P, Pusztai L. J Liq Biopsy. 2024 Dec; 2024 Sep 27. PMID: 40027305.", + "Datopotamab-deruxtecan in early-stage breast cancer: the sequential multiple assignment randomized I-SPY2.2 phase 2 trial. Khoury K, Meisel JL, Yau C, Rugo HS, Nanda R, Davidian M, Tsiatis B, Chien AJ, Wallace AM, Arora M, Rozenblit M, Hershman DL, Zimmer A, Clark AS, Beckwith H, Elias AD, Stringer-Reasor E, Boughey JC, Nangia C, Vaklavas C, Omene C, Albain KS, Kalinsky KM, Isaacs C, Tseng J, Roussos Torres ET, Thomas B, Thomas A, Sanford A, Balassanian R, Ewing C, Yeung K, Sauder C, Sanft T, Pusztai L, Trivedi MS, Outhaythip A, Li W, Onishi N, Asare AL, Beineke P, Norwood P, Brown-Swigart L, Hirst GL, Matthews JB, Moore B, Fraser Symmans W, Price E, Beedle C, Perlmutter J, Pohlmann P, Shatsky RA, DeMichele A, Yee D, van 't Veer LJ, Hylton NM, Esserman LJ. Nat Med. 2024 Dec; 2024 Sep 14. PMID: 39277671.", + "Phosphoenolpyruvate carboxykinase-2 (PCK2) is a therapeutic target in triple-negative breast cancer. Gunasekharan V, Lin HK, Marczyk M, Rios-Hoyo A, Campos GE, Shan NL, Ahmed M, Umlauf S, Gareiss P, Raaisa R, Williams R, Cardone R, Siebel S, Kibbey R, Surovtseva YV, Pusztai L. Breast Cancer Res Treat. 2024 Dec; 2024 Aug 23. PMID: 39177932.", + "Identification of HER2-positive breast cancer molecular subtypes with potential clinical implications in the ALTTO clinical trial. Rediti M, Venet D, Joaquin Garcia A, Maetens M, Vincent D, Majjaj S, El-Abed S, Di Cosimo S, Ueno T, Izquierdo M, Piccart M, Pusztai L, Loi S, Salgado R, Viale G, Rothé F, Sotiriou C. Nat Commun. 2024 Nov 29; 2024 Nov 29. PMID: 39613746.", + "Overall Survival with Pembrolizumab in Early-Stage Triple-Negative Breast Cancer. Schmid P, Cortes J, Dent R, McArthur H, Pusztai L, Kümmel S, Denkert C, Park YH, Hui R, Harbeck N, Takahashi M, Im SA, Untch M, Fasching PA, Mouret-Reynier MA, Foukakis T, Ferreira M, Cardoso F, Zhou X, Karantza V, Tryfonidis K, Aktan G, O'Shaughnessy J. N Engl J Med. 2024 Nov 28; 2024 Sep 15. PMID: 39282906.", + "Molecular adaptation to neoadjuvant immunotherapy in triple-negative breast cancer. Denkert C, Schneeweiss A, Rey J, Karn T, Hattesohl A, Weber KE, Rachakonda S, Braun M, Huober J, Jank P, Sinn HP, Zahm DM, Felder B, Hanusch C, Teply-Szymanski J, Marmé F, Fehm T, Thomalla J, Sinn BV, Stiewe T, Marczyk M, Blohmer JU, van Mackelenbergh M, Schem C, Staib P, Link T, Müller V, Stickeler E, Stover DG, Solbach C, Metzger-Filho O, Jackisch C, Geyer CE Jr, Fasching PA, Pusztai L, Nekljudova V, Untch M, Loibl S. Cell Rep Med. 2024 Nov 19. PMID: 39566464.", + "Multi-platform biomarkers of response to an immune checkpoint inhibitor in the neoadjuvant I-SPY 2 trial for early-stage breast cancer. Campbell MJ, Wolf DM, Yau C, Brown-Swigart L, Wulfkuhle J, Gallagher IR, Zhu Z, Bolen J, Vandenberg S, Hoyt C, Mori H, Borowsky A, Sit L, Perlmutter J, Asare SM, Nanda R, Liu MC, Yee D, DeMichele AM, Hylton NM, Pusztai L, Berry DA, Hirst GL, Petricoin EF, Veer LV, Esserman L. Cell Rep Med. 2024 Nov 19; 2024 Nov 6. PMID: 39510069.", + "The Immune-Related 27-Gene Signature DetermaIO Predicts Response to Neoadjuvant Atezolizumab plus Chemotherapy in Triple-Negative Breast Cancer. Dugo M, Huang CS, Egle D, Bermejo B, Zamagni C, Seitz RS, Nielsen TJ, Thill M, Antón-Torres A, Russo S, Ciruelos EM, Schweitzer BL, Ross DT, Galbardi B, Greil R, Semiglazov V, Gyorffy B, Colleoni M, Kelly CM, Mariani G, Del Mastro L, Blasi O, Callari M, Pusztai L, Valagussa P, Viale G, Gianni L, Bianchini G. Clin Cancer Res. 2024 Nov 1. PMID: 39308141.", + "Peripheral blood immune parameters, response, and adverse events after neoadjuvant chemotherapy plus durvalumab in early-stage triple-negative breast cancer. Foldi J, Blenman KRM, Marczyk M, Gunasekharan V, Polanska A, Gee R, Davis M, Kahn AM, Silber A, Pusztai L. Breast Cancer Res Treat. 2024 Nov; 2024 Jul 13. PMID: 39002068.", + "Academic Uphill Battle to Personalize Treatment for Patients With Stage II/III Triple-Negative Breast Cancer. Kok M, Gielen RJ, Adams S, Lennerz JK, Sharma P, Loibl S, Reardon E, Sonke G, Linn S, Delaloge S, Lacombe D, Robinson T, Badve S, Martin M, Balko JM, Ignatiadis M, Curigliano G, Wolff AC, Mittendorf EA, Loi S, Pusztai L, Tolaney SM, Salgado R. J Clin Oncol. 2024 Oct 20; 2024 Jul 22. PMID: 39038259.", + "Neoadjuvant pembrolizumab plus chemotherapy/adjuvant pembrolizumab for early-stage triple-negative breast cancer: quality-of-life results from the randomized KEYNOTE-522 study. Dent R, Cortés J, Pusztai L, McArthur H, Kümmel S, Bergh J, Denkert C, Park YH, Hui R, Harbeck N, Takahashi M, Untch M, Fasching PA, Cardoso F, Haiderali A, Jia L, Nguyen AM, Pan W, O'Shaughnessy J, Schmid P. J Natl Cancer Inst. 2024 Oct 1. PMID: 38913881.", + "Phase III Randomized, Placebo-Controlled Trial of Endocrine Therapy ± 1 Year of Everolimus in Patients With High-Risk, Hormone Receptor-Positive, Early-Stage Breast Cancer. Chavez-MacGregor M, Miao J, Pusztai L, Goetz MP, Rastogi P, Ganz PA, Mamounas EP, Paik S, Bandos H, Razaq W, O'Dea A, Kaklamani V, Silber ALM, Flaum LE, Andreopoulou E, Wendt AG, Carney JF, Sharma P, Gralow JR, Lew DL, Barlow WE, Hortobagyi GN. J Clin Oncol. 2024 Sep 1; 2024 Jun 4. PMID: 38833643.", + "Pre-treatment amino acids and risk of paclitaxel-induced peripheral neuropathy in SWOG S0221. Chen CS, Zirpoli G, Budd GT, Barlow WE, Pusztai L, Hortobagyi GN, Albain KS, Godwin AK, Thompson A, Henry NL, Ambrosone CB, Stringer KA, Hertz DL. Cancer Chemother Pharmacol. 2024 Aug; 2024 May 30. PMID: 38814343.", + "Neoadjuvant Chemotherapy and Immunotherapy for Estrogen Receptor-Positive Human Epidermal Growth Factor 2-Negative Breast Cancer. Ríos-Hoyo A, Cobain E, Huppert LA, Beitsch PD, Buchholz TA, Esserman L, van 't Veer LJ, Rugo HS, Pusztai L. J Clin Oncol. 2024 Aug 1; 2024 Apr 9. PMID: 38593393.", + "Associations amongst genes, molecules, cells, and organs in breast cancer metastasis. Nathanson SD, Dieterich LC, Zhang XH, Chitale DA, Pusztai L, Reynaud E, Wu YH, Ríos-Hoyo A. Clin Exp Metastasis. 2024 Aug; 2023 Sep 9. PMID: 37688650.", + "Completion Rate and Positive Results Reporting Among Immunotherapy Trials in Breast Cancer, 2004-2023. Mariani M, Viale G, Galbardi B, Licata L, Bosi C, Dugo M, Notini G, Naldini MM, Callari M, Criscitiello C, Pusztai L, Bianchini G. JAMA Netw Open. 2024 Jul 1; 2024 Jul 1. PMID: 39028669.", + "Navigating practical challenges in immunotherapy for metastatic triple negative breast cancer. Licata L, Dieci MV, De Angelis C, Marchiò C, Miglietta F, Cortesi L, Fabi A, Schmid P, Cortes J, Pusztai L, Bianchini G, Curigliano G. Cancer Treat Rev. 2024 Jul; 2024 May 16. PMID: 38776613.", + "Evaluation of large language models as a diagnostic aid for complex medical cases. Ríos-Hoyo A, Shan NL, Li A, Pearson AT, Pusztai L, Howard FM. Front Med (Lausanne). 2024; 2024 Jun 20. PMID: 38966538.", + "TROPION-Breast03: a randomized phase III global trial of datopotamab deruxtecan ± durvalumab in patients with triple-negative breast cancer and residual invasive disease at surgical resection after neoadjuvant therapy. Bardia A, Pusztai L, Albain K, Ciruelos EM, Im SA, Hershman D, Kalinsky K, Isaacs C, Loirat D, Testa L, Tokunaga E, Wu J, Dry H, Barlow W, Kozarski R, Maxwell M, Harbeck N, Sharma P. Ther Adv Med Oncol. 2024; 2024 Apr 29. PMID: 38686016.", + "Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer. Jahangir CA, Page DB, Broeckx G, Gonzalez CA, Burke C, Murphy C, Reis-Filho JS, Ly A, Harms PW, Gupta RR, Vieth M, Hida AI, Kahila M, Kos Z, van Diest PJ, Verbandt S, Thagaard J, Khiroya R, Abduljabbar K, Acosta Haab G, Acs B, Adams S, Almeida JS, Alvarado-Cabrero I, Azmoudeh-Ardalan F, Badve S, Baharun NB, Bellolio ER, Bheemaraju V, Blenman KR, Botinelly Mendonça Fujimoto L, Burgues O, Chardas A, Cheang MCU, Ciompi F, Cooper LA, Coosemans A, Corredor G, Dantas Portela FL, Deman F, Demaria S, Dudgeon SN, Elghazawy M, Fernandez-Martín C, Fineberg S, Fox SB, Giltnane JM, Gnjatic S, Gonzalez-Ericsson PI, Grigoriadis A, Halama N, Hanna MG, Harbhajanka A, Hart SN, Hartman J, Hewitt S, Horlings HM, Husain Z, Irshad S, Janssen EA, Kataoka TR, Kawaguchi K, Khramtsov AI, Kiraz U, Kirtani P, Kodach LL, Korski K, Akturk G, Scott E, Kovács A, Laenkholm AV, Lang-Schwarz C, Larsimont D, Lennerz JK, Lerousseau M, Li X, Madabhushi A, Maley SK, Manur Narasimhamurthy V, Marks DK, McDonald ES, Mehrotra R, Michiels S, Kharidehal D, Minhas FUAA, Mittal S, Moore DA, Mushtaq S, Nighat H, Papathomas T, Penault-Llorca F, Perera RD, Pinard CJ, Pinto-Cardenas JC, Pruneri G, Pusztai L, Rajpoot NM, Rapoport BL, Rau TT, Ribeiro JM, Rimm D, Vincent-Salomon A, Saltz J, Sayed S, Hytopoulos E, Mahon S, Siziopikou KP, Sotiriou C, Stenzinger A, Sughayer MA, Sur D, Symmans F, Tanaka S, Taxter T, Tejpar S, Teuwen J, Thompson EA, Tramm T, Tran WT, van der Laak J, Verghese GE, Viale G, Wahab N, Walter T, Waumans Y, Wen HY, Yang W, Yuan Y, Bartlett J, Loibl S, Denkert C, Savas P, Loi S, Specht Stovgaard E, Salgado R, Gallagher WM, Rahman A. J Pathol. 2024 Mar; 2024 Jan 17. PMID: 38230434.", + "Neoadjuvant Trebananib plus Paclitaxel-based Chemotherapy for Stage II/III Breast Cancer in the Adaptively Randomized I-SPY2 Trial-Efficacy and Biomarker Discovery. Albain KS, Yau C, Petricoin EF, Wolf DM, Lang JE, Chien AJ, Haddad T, Forero-Torres A, Wallace AM, Kaplan H, Pusztai L, Euhus D, Nanda R, Elias AD, Clark AS, Godellas C, Boughey JC, Isaacs C, Tripathy D, Lu J, Yung RL, Gallagher RI, Wulfkuhle JD, Brown-Swigart L, Krings G, Chen YY, Potter DA, Stringer-Reasor E, Blair S, Asare SM, Wilson A, Hirst GL, Singhrao R, Buxton M, Clennell JL, Sanil A, Berry S, Asare AL, Matthews JB, DeMichele AM, Hylton NM, Melisko M, Perlmutter J, Rugo HS, Symmans WF, Van't Veer LJ, Yee D, Berry DA, Esserman LJ. Clin Cancer Res. 2024 Feb 16. PMID: 38109213.", + "Core Needle Biopsies as an Alternative Source for Ex Vivo Expanded TIL for Adoptive Cell Therapy in Triple-Negative Breast Cancer. Coman MM, Pusztai L, Hooley R, Andreveja L, Kim L, Joshi N, Bersenev A, Krause D, Park TS. J Immunother. 2024 Feb-Mar 01; 2023 Nov 22. PMID: 37991241.", + "Race, Gene Expression Signatures, and Clinical Outcomes of Patients With High-Risk Early Breast Cancer. Kyalwazi B, Yau C, Campbell MJ, Yoshimatsu TF, Chien AJ, Wallace AM, Forero-Torres A, Pusztai L, Ellis ED, Albain KS, Blaes AH, Haley BB, Boughey JC, Elias AD, Clark AS, Isaacs CJ, Nanda R, Han HS, Yung RL, Tripathy D, Edmiston KK, Viscusi RK, Northfelt DW, Khan QJ, Asare SM, Wilson A, Hirst GL, Lu R, Symmans WF, Yee D, DeMichele AM, van 't Veer LJ, Esserman LJ, Olopade OI. JAMA Netw Open. 2023 Dec 1; 2023 Dec 1. PMID: 38153734.", + "Breast cancers with high proliferation and low ER-related signalling have poor prognosis and unique molecular features with implications for therapy. Licata L, Barreca M, Galbardi B, Dugo M, Viale G, Győrffy B, Karn T, Pusztai L, Gianni L, Callari M, Bianchini G. Br J Cancer. 2023 Dec; 2023 Nov 7. PMID: 37935787.", + "Pan-cancer analysis of antibody-drug conjugate targets and putative predictors of treatment response. Bosi C, Bartha Á, Galbardi B, Notini G, Naldini MM, Licata L, Viale G, Mariani M, Pistilli B, Ali HR, André F, Piras M, Callari M, Barreca M, Locatelli A, Viganò L, Criscitiello C, Pusztai L, Curigliano G, Győrffy B, Dugo M, Bianchini G. Eur J Cancer. 2023 Dec; 2023 Oct 11. PMID: 37913680.", + "De Novo Oligometastatic Breast Cancer. Pusztai L, Rozenblit M, Dubsky P, Bachelot T, Kirby AM, Linderholm BK, White JR, Chmura SJ, Carey LA, Chua BH, Miller KD. J Clin Oncol. 2023 Dec 1; 2023 Aug 22. PMID: 37607325.", + "Immunological and clinicopathological features predict HER2-positive breast cancer prognosis in the neoadjuvant NeoALTTO and CALGB 40601 randomized trials. Rediti M, Fernandez-Martinez A, Venet D, Rothé F, Hoadley KA, Parker JS, Singh B, Campbell JD, Ballman KV, Hillman DW, Winer EP, El-Abed S, Piccart M, Di Cosimo S, Symmans WF, Krop IE, Salgado R, Loi S, Pusztai L, Perou CM, Carey LA, Sotiriou C. Nat Commun. 2023 Nov 3; 2023 Nov 3. PMID: 37923752.", + "Pembrolizumab Plus Chemotherapy Followed by Pembrolizumab in Patients With Early Triple-Negative Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial. Takahashi M, Cortés J, Dent R, Pusztai L, McArthur H, Kümmel S, Denkert C, Park YH, Im SA, Ahn JH, Mukai H, Huang CS, Chen SC, Kim MH, Jia L, Li XT, Tryfonidis K, Karantza V, Iwata H, Schmid P. JAMA Netw Open. 2023 Nov 1; 2023 Nov 1. PMID: 37966841.", + "Vitamin D Insufficiency as a Risk Factor for Paclitaxel-Induced Peripheral Neuropathy in SWOG S0221. Chen CS, Zirpoli G, Barlow WE, Budd GT, McKiver B, Pusztai L, Hortobagyi GN, Albain KS, Damaj MI, Godwin AK, Thompson A, Henry NL, Ambrosone CB, Stringer KA, Hertz DL. J Natl Compr Canc Netw. 2023 Nov. PMID: 37935109.", + "Molecular Characterization of HER2-Low Invasive Breast Carcinoma by Quantitative RT-PCR Using Oncotype DX Assay. Lin HK, Can T, Kahn A, Flannery CA, Hoag J, Akkunuri A, Bailey H, Baehner R, Pusztai L, Rozenblit M. Oncologist. 2023 Oct 3. PMID: 37656608.", + "Neoadjuvant Immunotherapy in Early, Triple-Negative Breast Cancers: Catching Up with the Rest. Kim L, Coman M, Pusztai L, Park TS. Ann Surg Oncol. 2023 Oct; 2023 Jun 22. PMID: 37349612.", + "Evaluation of zero counts to better understand the discrepancies between bulk and single-cell RNA-Seq platforms. Zyla J, Papiez A, Zhao J, Qu R, Li X, Kluger Y, Polanska J, Hatzis C, Pusztai L, Marczyk M. Comput Struct Biotechnol J. 2023; 2023 Sep 29. PMID: 37841335.", + "Standardized Definitions for Efficacy End Points in Neoadjuvant Breast Cancer Clinical Trials: NeoSTEEP. Litton JK, Regan MM, Pusztai L, Rugo HS, Tolaney SM, Garrett-Mayer E, Amiri-Kordestani L, Basho RK, Best AF, Boileau JF, Denkert C, Foster JC, Harbeck N, Jacene HA, King TA, Mason G, O'Sullivan CC, Prowell TM, Richardson AL, Sepulveda KA, Smith ML, Tjoe JA, Turashvili G, Woodward WA, Butler LP, Schwartz EI, Korde LA. J Clin Oncol. 2023 Sep 20; 2023 Jul 11. PMID: 37433103.", + "Dual Prognostic Classification of Triple-Negative Breast Cancer by DNA Damage Immune Response and Homologous Recombination Deficiency. Stecklein SR, Barlow W, Pusztai L, Timms K, Kennedy R, Logan GE, Seitz R, Badve S, Gökmen-Polar Y, Porter P, Linden H, Tripathy D, Hortobagyi GN, Godwin AK, Thompson A, Hayes DF, Sharma P. JCO Precis Oncol. 2023 Sep. PMID: 37972336.", + "Treatment efficacy score: a better surrogate for arm-level survival differences in neoadjuvant breast cancer trials? Chehayeb RJ, Kahn A, Pusztai L. Future Oncol. 2023 Sep; 2023 Sep 28. PMID: 37767612.", + "Pre-treatment Amino Acids and Risk of Paclitaxel-induced Peripheral Neuropathy in SWOG S0221. Chen CS, Zirpoli G, Thomas Budd G, Barlow WE, Pusztai L, Hortobagyi GN, Albain KS, Godwin AK, Thompson A, Lynn Henry N, Ambrosone CB, Stringer KA, Hertz DL. Res Sq. 2023 Sep 1; 2023 Sep 1. PMID: 37693586.", + "Intratumor spatial heterogeneity in programmed death-ligand 1 (PD-L1) protein expression in early-stage breast cancer. Kahn AM, Golestani R, Harigopal M, Pusztai L. Breast Cancer Res Treat. 2023 Sep; 2023 Jun 28. PMID: 37378695.", + "Systemic Staging of Locally Advanced Breast Cancer: How Hard to Look? Pusztai L. J Clin Oncol. 2023 Aug 10; 2023 Jun 22. PMID: 37348030.", + "Effects of CYP3A4 and CYP2C9 genotype on systemic anastrozole and fulvestrant concentrations in SWOG S0226. Rutherford DV, Medley S, Henderson NC, Gersch CL, Vandenberg TA, Albain KS, Dakhil SR, Tirumali NR, Gralow JR, Hortobagyi GN, Pusztai L, Mehta RS, Hayes DF, Kidwell KM, Henry NL, Barlow WE, Rae JM, Hertz DL. Pharmacogenomics. 2023 Aug; 2023 Aug 24. PMID: 37615099.", + "Pitfalls in machine learning-based assessment of tumor-infiltrating lymphocytes in breast cancer: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. Thagaard J, Broeckx G, Page DB, Jahangir CA, Verbandt S, Kos Z, Gupta R, Khiroya R, Abduljabbar K, Acosta Haab G, Acs B, Akturk G, Almeida JS, Alvarado-Cabrero I, Amgad M, Azmoudeh-Ardalan F, Badve S, Baharun NB, Balslev E, Bellolio ER, Bheemaraju V, Blenman KR, Botinelly Mendonça Fujimoto L, Bouchmaa N, Burgues O, Chardas A, Chon U Cheang M, Ciompi F, Cooper LA, Coosemans A, Corredor G, Dahl AB, Dantas Portela FL, Deman F, Demaria S, Doré Hansen J, Dudgeon SN, Ebstrup T, Elghazawy M, Fernandez-Martín C, Fox SB, Gallagher WM, Giltnane JM, Gnjatic S, Gonzalez-Ericsson PI, Grigoriadis A, Halama N, Hanna MG, Harbhajanka A, Hart SN, Hartman J, Hauberg S, Hewitt S, Hida AI, Horlings HM, Husain Z, Hytopoulos E, Irshad S, Janssen EA, Kahila M, Kataoka TR, Kawaguchi K, Kharidehal D, Khramtsov AI, Kiraz U, Kirtani P, Kodach LL, Korski K, Kovács A, Laenkholm AV, Lang-Schwarz C, Larsimont D, Lennerz JK, Lerousseau M, Li X, Ly A, Madabhushi A, Maley SK, Manur Narasimhamurthy V, Marks DK, McDonald ES, Mehrotra R, Michiels S, Minhas FUAA, Mittal S, Moore DA, Mushtaq S, Nighat H, Papathomas T, Penault-Llorca F, Perera RD, Pinard CJ, Pinto-Cardenas JC, Pruneri G, Pusztai L, Rahman A, Rajpoot NM, Rapoport BL, Rau TT, Reis-Filho JS, Ribeiro JM, Rimm D, Roslind A, Vincent-Salomon A, Salto-Tellez M, Saltz J, Sayed S, Scott E, Siziopikou KP, Sotiriou C, Stenzinger A, Sughayer MA, Sur D, Fineberg S, Symmans F, Tanaka S, Taxter T, Tejpar S, Teuwen J, Thompson EA, Tramm T, Tran WT, van der Laak J, van Diest PJ, Verghese GE, Viale G, Vieth M, Wahab N, Walter T, Waumans Y, Wen HY, Yang W, Yuan Y, Zin RM, Adams S, Bartlett J, Loibl S, Denkert C, Savas P, Loi S, Salgado R, Specht Stovgaard E. J Pathol. 2023 Aug; 2023 Aug 23. PMID: 37608772.", + "Spatial analyses of immune cell infiltration in cancer: current methods and future directions: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. Page DB, Broeckx G, Jahangir CA, Verbandt S, Gupta RR, Thagaard J, Khiroya R, Kos Z, Abduljabbar K, Acosta Haab G, Acs B, Akturk G, Almeida JS, Alvarado-Cabrero I, Azmoudeh-Ardalan F, Badve S, Baharun NB, Bellolio ER, Bheemaraju V, Blenman KR, Botinelly Mendonça Fujimoto L, Bouchmaa N, Burgues O, Cheang MCU, Ciompi F, Cooper LA, Coosemans A, Corredor G, Dantas Portela FL, Deman F, Demaria S, Dudgeon SN, Elghazawy M, Ely S, Fernandez-Martín C, Fineberg S, Fox SB, Gallagher WM, Giltnane JM, Gnjatic S, Gonzalez-Ericsson PI, Grigoriadis A, Halama N, Hanna MG, Harbhajanka A, Hardas A, Hart SN, Hartman J, Hewitt S, Hida AI, Horlings HM, Husain Z, Hytopoulos E, Irshad S, Janssen EA, Kahila M, Kataoka TR, Kawaguchi K, Kharidehal D, Khramtsov AI, Kiraz U, Kirtani P, Kodach LL, Korski K, Kovács A, Laenkholm AV, Lang-Schwarz C, Larsimont D, Lennerz JK, Lerousseau M, Li X, Ly A, Madabhushi A, Maley SK, Manur Narasimhamurthy V, Marks DK, McDonald ES, Mehrotra R, Michiels S, Minhas FUAA, Mittal S, Moore DA, Mushtaq S, Nighat H, Papathomas T, Penault-Llorca F, Perera RD, Pinard CJ, Pinto-Cardenas JC, Pruneri G, Pusztai L, Rahman A, Rajpoot NM, Rapoport BL, Rau TT, Reis-Filho JS, Ribeiro JM, Rimm D, Vincent-Salomon A, Salto-Tellez M, Saltz J, Sayed S, Siziopikou KP, Sotiriou C, Stenzinger A, Sughayer MA, Sur D, Symmans F, Tanaka S, Taxter T, Tejpar S, Teuwen J, Thompson EA, Tramm T, Tran WT, van der Laak J, van Diest PJ, Verghese GE, Viale G, Vieth M, Wahab N, Walter T, Waumans Y, Wen HY, Yang W, Yuan Y, Adams S, Bartlett JMS, Loibl S, Denkert C, Savas P, Loi S, Salgado R, Specht Stovgaard E. J Pathol. 2023 Aug; 2023 Aug 23. PMID: 37608771.", + "Radiotherapy Use and Incidence of Locoregional Recurrence in Patients With Favorable-Risk, Node-Positive Breast Cancer Enrolled in the SWOG S1007 Trial. Jagsi R, Barlow WE, Woodward WA, Connolly E, Mahtani R, Shumway D, Speers C, Stecklein SR, Zeidan Y, Zhang H, Sharma P, Pusztai L, Hortobagyi GN, Kalinsky K. JAMA Oncol. 2023 Aug 1. PMID: 37410451.", + "More than bad luck: Cancer and aging are linked to replication-driven changes to the epigenome. Minteer CJ, Thrush K, Gonzalez J, Niimi P, Rozenblit M, Rozowsky J, Liu J, Frank M, McCabe T, Higgins-Chen AT, Hofstatter E, Pusztai L, Beckman K, Gerstein M, Levine ME. Sci Adv. 2023 Jul 21; 2023 Jul 19. PMID: 37467337.", + "Persistence to extended adjuvant endocrine therapy following Breast Cancer Index (BCI) testing in women with early-stage hormone receptor-positive (HR +) breast cancer. Foldi J, Tsagianni A, Salganik M, Schnabel CA, Brufsky A, van Londen GJ, Pusztai L, Sanft T. BMC Cancer. 2023 Jun 30; 2023 Jun 30. PMID: 37391697.", + "Incorporating clinicopathological and molecular risk prediction tools to improve outcomes in early HR+/HER2- breast cancer. Curigliano G, Dent R, Llombart-Cussac A, Pegram M, Pusztai L, Turner N, Viale G. NPJ Breast Cancer. 2023 Jun 28; 2023 Jun 28. PMID: 37380659.", + "Oncotype DX results increase concordance in adjuvant chemotherapy recommendations for early-stage breast cancer. Licata L, Viale G, Giuliano M, Curigliano G, Chavez-MacGregor M, Foldi J, Oke O, Collins J, Del Mastro L, Puglisi F, Montemurro F, Vernieri C, Gerratana L, Giordano S, Rognone A, Sica L, Gentilini OD, Cascinu S, Pusztai L, Giordano A, Criscitiello C, Bianchini G. NPJ Breast Cancer. 2023 Jun 8; 2023 Jun 8. PMID: 37291235.", + "Image analysis-based tumor infiltrating lymphocytes measurement predicts breast cancer pathologic complete response in SWOG S0800 neoadjuvant chemotherapy trial. Fanucci KA, Bai Y, Pelekanou V, Nahleh ZA, Shafi S, Burela S, Barlow WE, Sharma P, Thompson AM, Godwin AK, Rimm DL, Hortobagyi GN, Liu Y, Wang L, Wei W, Pusztai L, Blenman KRM. NPJ Breast Cancer. 2023 May 13; 2023 May 13. PMID: 37179362.", + "Assessment of stained direct cytology smears of breast cancer for whole transcriptome and targeted messenger RNA sequencing. Marczyk M, Fu C, Lau R, Du L, Trevarton AJ, Sinn BV, Gould RE, Pusztai L, Hatzis C, Symmans WF. Cancer Cytopathol. 2023 May; 2023 Jan 17. PMID: 36650408.", + "Thymidine kinase activity levels in serum can identify HR+ metastatic breast cancer patients with a low risk of early progression (SWOG S0226). Bergqvist M, Nordmark A, Williams A, Paoletti C, Barlow W, Cobain EF, Mehta RS, Gralow JR, Hortobagyi GN, Albain KS, Pusztai L, Sharma P, Godwin AK, Thompson AM, Hayes DF, Rae JM. Biomarkers. 2023 May; 2023 Jan 29. PMID: 36647745.", + "Variable Landscape of PD-L1 Expression in Breast Carcinoma as Detected by the DAKO 22C3 Immunohistochemistry Assay. Danziger N, Sokol ES, Graf RP, Hiemenz MC, Maule J, Parimi V, Palmieri C, Pusztai L, Ross JS, Huang RSP. Oncologist. 2023 Apr 6. PMID: 36866462.", + "Evaluation of the Sensitivity to Endocrine Therapy Index and 21-Gene Breast Recurrence Score in the SWOG S8814 Trial. Speers CW, Symmans WF, Barlow WE, Trevarton A, The S, Du L, Rae JM, Shak S, Baehner R, Sharma P, Pusztai L, Hortobagyi GN, Hayes DF, Albain KS, Godwin A, Thompson A. J Clin Oncol. 2023 Apr 1; 2023 Jan 17. PMID: 36649570.", + "In silico designed mRNA vaccines targeting CA-125 neoantigen in breast and ovarian cancer. Lu L, Ma W, Johnson CH, Khan SA, Irwin ML, Pusztai L. Vaccine. 2023 Mar 17; 2023 Feb 20. PMID: 36813666.", + "AKT/mTOR signaling modulates resistance to endocrine therapy and CDK4/6 inhibition in metastatic breast cancers. Abu-Khalaf MM, Alex Hodge K, Hatzis C, Baldelli E, El Gazzah E, Valdes F, Sikov WM, Mita MM, Denduluri N, Murphy R, Zelterman D, Liotta L, Dunetz B, Dunetz R, Petricoin EF, Pierobon M. NPJ Precis Oncol. 2023 Feb 16; 2023 Feb 16. PMID: 36797347.", + "Cisplatin with veliparib or placebo in metastatic triple-negative breast cancer and BRCA mutation-associated breast cancer (S1416): a randomised, double-blind, placebo-controlled, phase 2 trial. Rodler E, Sharma P, Barlow WE, Gralow JR, Puhalla SL, Anders CK, Goldstein L, Tripathy D, Brown-Glaberman UA, Huynh TT, Szyarto CS, Godwin AK, Pathak HB, Swisher EM, Radke MR, Timms KM, Lew DL, Miao J, Pusztai L, Hayes DF, Hortobagyi GN. Lancet Oncol. 2023 Feb; 2023 Jan 6. PMID: 36623515.", + "Intratumour heterogeneity, from hypothesis to the clinic. Shan NL, Kahn A, Pusztai L. Br J Cancer. 2023 Feb; 2022 Oct 10. PMID: 36216884.", + "Impact of Anti-HER2 Therapy Alone and With Weekly Paclitaxel on the Ovarian Reserve of Young Women With HER2-Positive Breast Cancer. Lambertini M, Ceppi M, Anderson RA, Cameron DA, Bruzzone M, Franzoi MA, Massarotti C, El-Abed S, Wang Y, Lecocq C, Nuciforo P, Rolyance R, Pusztai L, Sohn J, Latocca MM, Arecco L, Pistilli B, Ruddy KJ, Ballestrero A, Del Mastro L, Peccatori FA, Partridge AH, Saura C, Untch M, Piccart M, Di Cosimo S, de Azambuja E, Demeestere I. J Natl Compr Canc Netw. 2023 Jan. PMID: 36634607.", + "Tumor-Derived Extracellular Vesicles as Complementary Prognostic Factors to Circulating Tumor Cells in Metastatic Breast Cancer. Nanou A, Miao J, Coumans FAW, Dolce EM, Darga E, Barlow W, Smerage JB, Paoletti C, Godwin AK, Pusztai L, Sharma P, Thompson A, Hortobagyi GN, Terstappen LWMM, Hayes DF. JCO Precis Oncol. 2023 Jan. PMID: 36634296.", + "Molecular differences between younger versus older ER-positive and HER2-negative breast cancers. Qing T, Karn T, Rozenblit M, Foldi J, Marczyk M, Shan NL, Blenman K, Holtrich U, Kalinsky K, Meric-Bernstam F, Pusztai L. NPJ Breast Cancer. 2022 Nov 7; 2022 Nov 7. PMID: 36344517.", + "Treatment Sequencing Patterns and Associated Direct Medical Costs of Metastatic Breast Cancer Care in the United States, 2011 to 2021. Jaber Chehayeb R, Hood A, Wang X, Miksad R, Schellhorn Mougalian S, Lustberg MB, Wang SY, Greenup RA, Pusztai L, Kunst N. JAMA Netw Open. 2022 Nov 1; 2022 Nov 1. PMID: 36445704.", + "PD-L1 protein expression in relation to recurrence score values in early-stage ER + breast cancer. Rozenblit M, Blenman K, Harigopal M, Reisenbichler E, Singh K, Qing T, Ibrahim E, Ramkissoon S, Asmelash S, Lin HK, Roberts M, Ross J, Huang RSP, Pusztai L. Breast Cancer Res Treat. 2022 Nov; 2022 Aug 26. PMID: 36028784.", + "A preliminary, prospective study of peripheral neuropathy and cognitive function in patients with breast cancer during taxane therapy. Ibrahim EY, Munshani S, Domenicano I, Rodwin R, Nowak RJ, Pusztai L, Lustberg M, Ehrlich BE. PLoS One. 2022; 2022 Oct 7. PMID: 36206298.", + "The effectiveness of immune checkpoint inhibitors in the neoadjuvant and post-neoadjuvant breast cancer settings. Pusztai L. Clin Adv Hematol Oncol. 2022 Sep. PMID: 36125946.", + "Clinical Outcomes and Immune Markers by Race in a Phase I/II Clinical Trial of Durvalumab Concomitant with Neoadjuvant Chemotherapy in Early-Stage TNBC. Foldi J, Kahn A, Silber A, Qing T, Reisenbichler E, Fischbach N, Persico J, Adelson K, Katoch A, Chagpar A, Park T, Blanchard A, Blenman K, Rimm DL, Pusztai L. Clin Cancer Res. 2022 Sep 1. PMID: 35903931.", + "Tumor immune microenvironment of self-identified African American and non-African American triple negative breast cancer. Marczyk M, Qing T, O'Meara T, Yagahoobi V, Pelekanou V, Bai Y, Reisenbichler E, Cole KS, Li X, Gunasekharan V, Ibrahim E, Fanucci K, Wei W, Rimm DL, Pusztai L, Blenman KRM. NPJ Breast Cancer. 2022 Jul 22; 2022 Jul 22. PMID: 35869114.", + "Cancer Relevance of Human Genes. Qing T, Mohsen H, Cannataro VL, Marczyk M, Rozenblit M, Foldi J, Murray M, Townsend JP, Kluger Y, Gerstein M, Pusztai L. J Natl Cancer Inst. 2022 Jul 11. PMID: 35417011.", + "Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies. Wolf DM, Yau C, Wulfkuhle J, Brown-Swigart L, Gallagher RI, Lee PRE, Zhu Z, Magbanua MJ, Sayaman R, O'Grady N, Basu A, Delson A, Coppé JP, Lu R, Braun J, Asare SM, Sit L, Matthews JB, Perlmutter J, Hylton N, Liu MC, Pohlmann P, Symmans WF, Rugo HS, Isaacs C, DeMichele AM, Yee D, Berry DA, Pusztai L, Petricoin EF, Hirst GL, Esserman LJ, van 't Veer LJ. Cancer Cell. 2022 Jun 13; 2022 May 26. PMID: 35623341.", + "Predictive Markers of Response to Neoadjuvant Durvalumab with Nab-Paclitaxel and Dose-Dense Doxorubicin/Cyclophosphamide in Basal-Like Triple-Negative Breast Cancer. Blenman KRM, Marczyk M, Karn T, Qing T, Li X, Gunasekharan V, Yaghoobi V, Bai Y, Ibrahim EY, Park T, Silber A, Wolf DM, Reisenbichler E, Denkert C, Sinn BV, Rozenblit M, Foldi J, Rimm DL, Loibl S, Pusztai L. Clin Cancer Res. 2022 Jun 13. PMID: 35377948.", + "Biomarkers for Adjuvant Endocrine and Chemotherapy in Early-Stage Breast Cancer: ASCO Guideline Update. Andre F, Ismaila N, Allison KH, Barlow WE, Collyar DE, Damodaran S, Henry NL, Jhaveri K, Kalinsky K, Kuderer NM, Litvak A, Mayer EL, Pusztai L, Raab R, Wolff AC, Stearns V. J Clin Oncol. 2022 Jun 1; 2022 Apr 19. PMID: 35439025.", + "Comprehensive Analysis of Metabolic Isozyme Targets in Cancer. Marczyk M, Gunasekharan V, Casadevall D, Qing T, Foldi J, Sehgal R, Shan NL, Blenman KRM, O'Meara TA, Umlauf S, Surovtseva YV, Muthusamy V, Rinehart J, Perry RJ, Kibbey R, Hatzis C, Pusztai L. Cancer Res. 2022 May 3. PMID: 35247885.", + "Examination of Low ERBB2 Protein Expression in Breast Cancer Tissue. Fernandez AI, Liu M, Bellizzi A, Brock J, Fadare O, Hanley K, Harigopal M, Jorns JM, Kuba MG, Ly A, Podoll M, Rabe K, Sanders MA, Singh K, Snir OL, Soong TR, Wei S, Wen H, Wong S, Yoon E, Pusztai L, Reisenbichler E, Rimm DL. JAMA Oncol. 2022 Apr 1. PMID: 35113160.", + "300 George Street New Haven, CT 06520-8028", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Brian Hafler Lab", + "lab_url": "https://medicine.yale.edu/lab/b-hafler/", + "research_bio": "INFORMATION FOR Copy Link A) A sketch of the human retina. The retina is a thin tissue that lies on the inner part of the eyeball that processes light into neural signals that are transmitted through the optic nerve to the brain. B) Age-related macular degeneration has an early dry stage where there is accumulation of drusen debris beneath the retina. Drusen lead to activation of the innate immune response and neuroinflammation. During the late advanced stage of age-related macular degeneration, pathological new blood vessel formation occurs that can lead to permanent vision loss through the death of photoreceptors. Accumulation of extracellular plaques and intracellular neurofibrillary tangles in Alzheimer's disease and myelin damage in progressive multiple sclerosis are similarly accompanied by microglia (blue) and astrocyte (orange) activation. C) In collaboration with Smita Krishnaswamy’s lab in the Department of Genetics and Computer Science, an algorithm diffusion condensation was developed and applied to new age-related macular degeneration single-cell data. This panels shows a visual description of the cellular condensation process undertaken by diffusion condensation across four granularities. Points are moved to and merged with their nearest neighbors as determined by a weighted random walk over the data graph. Over many successive iterations, cells collapse, denoting cluster identity at various iterations. D) The process described in (C) creates hundreds of granularities of clusters whic Our data (Menon et al., 2019 Nature Comm, Mathys et al. 2019 Nature, Kuchroo et al., 2021, bioRxiv) based on single cell analysis of healthy retinas and diseased retinas with macular degeneration and glaucoma indicate that the key inflammatory pathways reside in specialized glial cells known as astrocytes, Muller glia, and microglia. Our novel machine learning pipeline identified neuroinflammatory cytokines that promote disease progression, cause vision loss, and provide a genetic context to target these cell types and signaling pathways as a novel disease therapeutic to prevent vision loss in people suffering from these diseases. Most of our research is performed using human tissue, mouse, and glial cell cultures.", + "publications_page": "https://medicine.yale.edu/lab/b-hafler/publications", + "publications": [ + "Yale School of Medicine /", + "Ophthalmology /", + "People", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "People", + "Publications", + "News", + "", + "", + "", + "", + "", + "", + "SARS-CoV-2 induces Alzheimer's disease-related amyloid-β pathology in ex vivo human retinal explants and retinal organoids. Miller SJ, Dhodapkar RM, Sutova HE, Xue Y, Lee S, Logan R, Ran C, Bhatta S, Gomm A, Ju IG, Heyang M, Darji RY, DiStasio M, Tanzi RE, Zhang C, Zhou ZJ, Hafler BP. Sci Adv. 2025 Jul 4; 2025 Jul 4. PMID: 40614201.", + "Single-cell analysis reveals inflammatory interactions driving macular degeneration. Kuchroo M, DiStasio M, Song E, Calapkulu E, Zhang L, Ige M, Sheth AH, Majdoubi A, Menon M, Tong A, Godavarthi A, Xing Y, Gigante S, Steach H, Huang J, Huguet G, Narain J, You K, Mourgkos G, Dhodapkar RM, Hirn MJ, Rieck B, Wolf G, Krishnaswamy S, Hafler BP. Nat Commun. 2023 May 5; 2023 May 5. PMID: 37147305.", + "Innate immune biology in age-related macular degeneration. Ascunce K, Dhodapkar RM, Huang D, Hafler BP. Front Cell Dev Biol. 2023; 2023 Feb 28. PMID: 36926522.", + "Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa. Mercau ME, Akalu YT, Mazzoni F, Gyimesi G, Alberto EJ, Kong Y, Hafler BP, Finnemann SC, Rothlin CV, Ghosh S. Sci Adv. 2023 Jan 20; 2023 Jan 20. PMID: 36662852.", + "Glial-mediated neuroinflammatory mechanisms in age-related macular degeneration. Dhodapkar RM, Martell D, Hafler BP. Semin Immunopathol. 2022 Sep; 2022 May 5. PMID: 35513496.", + "Utilization of Crowdfunding for Cataract and LASIK Procedures. Patil SA, Luu A, Vail DG, Watane A, Levine R, Hafler B, Parikh R. Semin Ophthalmol. 2022 Jul 4; 2022 Mar 30. PMID: 35353643.", + "Altered photoreceptor metabolism in mouse causes late stage age-related macular degeneration-like pathologies. Cheng SY, Cipi J, Ma S, Hafler BP, Kanadia RN, Brush RS, Agbaga MP, Punzo C. Proc Natl Acad Sci U S A. 2020 Jun 9; 2020 May 20. PMID: 32434914.", + "Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration. Menon M, Mohammadi S, Davila-Velderrain J, Goods BA, Cadwell TD, Xing Y, Stemmer-Rachamimov A, Shalek AK, Love JC, Kellis M, Hafler BP. Nat Commun. 2019 Oct 25; 2019 Oct 25. PMID: 31653841.", + "Author Correction: Single-cell transcriptomic analysis of Alzheimer's disease. Mathys H, Davila-Velderrain J, Peng Z, Gao F, Mohammadi S, Young JZ, Menon M, He L, Abdurrob F, Jiang X, Martorell AJ, Ransohoff RM, Hafler BP, Bennett DA, Kellis M, Tsai LH. Nature. 2019 Jul. PMID: 31209304.", + "Single-cell transcriptomic analysis of Alzheimer's disease. Mathys H, Davila-Velderrain J, Peng Z, Gao F, Mohammadi S, Young JZ, Menon M, He L, Abdurrob F, Jiang X, Martorell AJ, Ransohoff RM, Hafler BP, Bennett DA, Kellis M, Tsai LH. Nature. 2019 Jun; 2019 May 1. PMID: 31042697.", + "CLINICAL PROGRESS IN INHERITED RETINAL DEGENERATIONS: GENE THERAPY CLINICAL TRIALS AND ADVANCES IN GENETIC SEQUENCING. Hafler BP. Retina. 2017 Mar. PMID: 27753762.", + "Course of Ocular Function in PRPF31 Retinitis Pigmentosa. Hafler BP, Comander J, Weigel DiFranco C, Place EM, Pierce EA. Semin Ophthalmol. 2016. PMID: 26959129.", + "Progressive retinal degeneration and accumulation of autofluorescent lipopigments in Progranulin deficient mice. Hafler BP, Klein ZA, Jimmy Zhou Z, Strittmatter SM. Brain Res. 2014 Nov 7; 2014 Sep 16. PMID: 25234724.", + "Angiophagy prevents early embolus washout but recanalizes microvessels through embolus extravasation. Grutzendler J, Murikinati S, Hiner B, Ji L, Lam CK, Yoo T, Gupta S, Hafler BP, Adelman RA, Yuan P, Rodriguez G. Sci Transl Med. 2014 Mar 5. PMID: 24598589.", + "Transcription factor Olig2 defines subpopulations of retinal progenitor cells biased toward specific cell fates. Hafler BP, Surzenko N, Beier KT, Punzo C, Trimarchi JM, Kong JH, Cepko CL. Proc Natl Acad Sci U S A. 2012 May 15; 2012 Apr 27. PMID: 22543161.", + "Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity. Benchabane H, Xin N, Tian A, Hafler BP, Nguyen K, Ahmed A, Ahmed Y. EMBO J. 2011 Apr 20; 2011 Mar 11. PMID: 21399610.", + "Expression and function of Nkx6.3 in vertebrate hindbrain. Hafler BP, Choi MY, Shivdasani RA, Rowitch DH. Brain Res. 2008 Jul 30; 2008 May 6. PMID: 18586225.", + "Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube. Sun T, Hafler BP, Kaing S, Kitada M, Ligon KL, Widlund HR, Yuk DI, Stiles CD, Rowitch DH. Dev Biol. 2006 Apr 1; 2006 Feb 8. PMID: 16469306.", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Bruce Lab", + "lab_url": "https://medicine.yale.edu/lab/bruce/", + "research_bio": "INFORMATION FOR Copy Link Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/bruce/publications", + "publications": [ + "Yale School of Medicine /", + "Neuroscience /", + "People", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "People", + "Publications", + "", + "", + "", + "", + "", + "", + "Sterling Hall of Medicine 333 Cedar Street PO Box 208001 New Haven, CT 06520-8001", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Brueckner Lab", + "lab_url": "https://medicine.yale.edu/lab/brueckner/", + "research_bio": "INFORMATION FOR We study the development of left right asymmetry, and the role of cilia in left-right and heart development utilizing mouse models, Xenopus tropicalis and human genetics. Vertebrate left-right asymmetry is essential for development of normal heart structure, and abnormal LR development manifests as severe congenital heart disease in humans. The major foci of the lab are to identify the genetic program underlying vertebrate left-right development through genomic analysis of patients with disorders of left-right development, to study how the ciliated organizer of asymmetry breaks bilateral symmetry and to analyze the mechanism of cardiac cilia in the direct control of heart morphogenesis. Our Laboratory Research includes studies regardingCilia in Left-Right Development,Cilia in Cardiac Development, andGenetic Control in Human Heterotoxy. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/brueckner/publications/", + "publications": [ + "Yale School of Medicine /", + "Pediatrics /", + "Research", + "Contact", + "Lab Members", + "Protocols", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Lab Members", + "Protocols", + "Publications", + "Contact", + "", + "", + "", + "", + "", + "", + "Endocardial primary cilia and blood flow regulate EndoMT during endocardial cushion development. Berg K, Gorham J, Lundt F, Seidman J, Brueckner M. Nat Cardiovasc Res. 2025 Sep; 2025 Aug 26. PMID: 40858839.", + "Enrichment of tandem repeat element variants near CHD genes identified by short- and long-read genome sequencing. Suresh A, Morton SU, Quiat D, DePalma SR, Gorham JM, Brueckner M, Tristani-Firouzi M, Gelb BD, Seidman JG, Seidman CE. BMC Med Genomics. 2025 Jul 25; 2025 Jul 25. PMID: 40713712.", + "Genome sequencing is critical for forecasting outcomes following congenital cardiac surgery. Watkins WS, Hernandez EJ, Miller TA, Blue NR, Zimmerman RM, Griffiths ER, Frise E, Bernstein D, Boskovski MT, Brueckner M, Chung WK, Gaynor JW, Gelb BD, Goldmuntz E, Gruber PJ, Newburger JW, Roberts AE, Morton SU, Mayer JE Jr, Seidman CE, Seidman JG, Shen Y, Wagner M, Yost HJ, Yandell M, Tristani-Firouzi M. Nat Commun. 2025 Jul 10; 2025 Jul 10. PMID: 40640177.", + "Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes. Sierant MC, Jin SC, Bilguvar K, Morton SU, Dong W, Jiang W, Lu Z, Li B, López-Giráldez F, Tikhonova I, Zeng X, Lu Q, Choi J, Zhang J, Nelson-Williams C, Knight JR, Zhao H, Cao J, Mane S, Sedore SC, Gruber PJ, Lek M, Goldmuntz E, Deanfield J, Giardini A, Mital S, Russell M, Gaynor JW, King E, Wagner M, Srivastava D, Shen Y, Bernstein D, Porter GA Jr, Newburger JW, Seidman JG, Roberts AE, Yandell M, Yost HJ, Tristani-Firouzi M, Kim R, Chung WK, Gelb BD, Seidman CE, Brueckner M, Lifton RP. Proc Natl Acad Sci U S A. 2025 Apr; 2025 Mar 24. PMID: 40127276.", + "Recessive genetic contribution to congenital heart disease in 5,424 probands. Dong W, Jin SC, Sierant MC, Lu Z, Li B, Lu Q, Morton SU, Zhang J, López-Giráldez F, Nelson-Williams C, Knight JR, Zhao H, Cao J, Mane S, Gruber PJ, Lek M, Goldmuntz E, Deanfield J, Giardini A, Mital S, Russell M, Gaynor JW, Cnota JF, Wagner M, Srivastava D, Bernstein D, Porter GA Jr, Newburger J, Roberts AE, Yandell M, Yost HJ, Tristani-Firouzi M, Kim R, Seidman J, Chung WK, Gelb BD, Seidman CE, Lifton RP, Brueckner M. Proc Natl Acad Sci U S A. 2025 Mar 11; 2025 Mar 3. PMID: 40030011.", + "Modeling SMAD2 Mutations in Induced Pluripotent Stem Cells Provides Insights Into Cardiovascular Disease Pathogenesis. Ward T, Morton SU, Venturini G, Tai W, Jang MY, Gorham J, Delaughter D, Wasson LK, Khazal Z, Homsy J, Gelb BD, Chung WK, Bruneau BG, Brueckner M, Tristani-Firouzi M, DePalma SR, Seidman C, Seidman JG. J Am Heart Assoc. 2025 Mar 4; 2025 Mar 3. PMID: 40028843.", + "Noncoding variants and sulcal patterns in congenital heart disease: Machine learning to predict functional impact. Mondragon-Estrada E, Newburger JW, DePalma SR, Brueckner M, Cleveland J, Chung WK, Gelb BD, Goldmuntz E, Hagler DJ Jr, Huang H, McQuillen P, Miller TA, Panigrahy A, Porter GA Jr, Roberts AE, Rollins CK, Russell MW, Tristani-Firouzi M, Grant PE, Im K, Morton SU. iScience. 2025 Feb 21; 2024 Dec 28. PMID: 39877905.", + "De novo variants in FRYL are associated with developmental delay, intellectual disability, and dysmorphic features. Pan X, Tao AM, Lu S, Ma M, Hannan SB, Slaugh R, Drewes Williams S, O'Grady L, Kanca O, Person R, Carter MT, Platzer K, Schnabel F, Abou Jamra R, Roberts AE, Newburger JW, Revah-Politi A, Granadillo JL, Stegmann APA, Sinnema M, Accogli A, Salpietro V, Capra V, Ghaloul-Gonzalez L, Brueckner M, Simon MEH, Sweetser DA, Glinton KE, Kirk SE, Wangler MF, Yamamoto S, Chung WK, Bellen HJ. Am J Hum Genet. 2024 Apr 4; 2024 Mar 12. PMID: 38479391.", + "Reply to Pisan et al.: Pathogenicity of inherited TRAF7 mutations in congenital heart disease. Mishra-Gorur K, Barak T, Kaulen LD, Henegariu O, Jin SC, Aguilera SM, Yalbir E, Goles G, Nishimura S, Miyagishima D, Djenoune L, Altinok S, Rai DK, Viviano S, Prendergast A, Zerillo C, Ozcan K, Baran B, Sencar L, Goc N, Yarman Y, Ercan-Encicek AG, Bilguvar K, Lifton RP, Moliterno J, Louvi A, Yuan S, Deniz E, Brueckner M, Gunel M. Proc Natl Acad Sci U S A. 2024 Mar 19; 2024 Mar 11. PMID: 38466853.", + "Association of genetic and sulcal traits with executive function in congenital heart disease. Maleyeff L, Newburger JW, Wypij D, Thomas NH, Anagnoustou E, Brueckner M, Chung WK, Cleveland J, Cunningham S, Gelb BD, Goldmuntz E, Hagler DJ Jr, Huang H, King E, McQuillen P, Miller TA, Norris-Brilliant A, Porter GA Jr, Roberts AE, Grant PE, Im K, Morton SU. Ann Clin Transl Neurol. 2024 Feb; 2023 Nov 27. PMID: 38009418.", + "SMC5 Plays Independent Roles in Congenital Heart Disease and Neurodevelopmental Disability. O'Brien MP, Pryzhkova MV, Lake EMR, Mandino F, Shen X, Karnik R, Atkins A, Xu MJ, Ji W, Konstantino M, Brueckner M, Ment LR, Khokha MK, Jordan PW. Int J Mol Sci. 2023 Dec 28; 2023 Dec 28. PMID: 38203602.", + "The H2Bub1-deposition complex is required for human and mouse cardiogenesis. Barish S, Berg K, Drozd J, Berglund-Brown I, Khizir L, Wasson LK, Seidman CE, Seidman JG, Chen S, Brueckner M. Development. 2023 Dec 1; 2023 Dec 1. PMID: 38038666.", + "Single-cell reconstruction and mutation enrichment analysis identifies dysregulated cardiomyocyte and endothelial cells in congenital heart disease. Tambi R, Zehra B, Nandkishore S, Sharafat S, Kader F, Nassir N, Mohamed N, Ahmed A, Abdel Hameid R, Alasrawi S, Brueckner M, Kuebler WM, Chung WK, Alsheikh-Ali A, Di Donato RM, Uddin M, Berdiev BK. Physiol Genomics. 2023 Dec 1; 2023 Oct 9. PMID: 37811720.", + "Contribution of Previously Unrecognized RNA Splice-Altering Variants to Congenital Heart Disease. Jang MY, Patel PN, Pereira AC, Willcox JAL, Haghighi A, Tai AC, Ito K, Morton SU, Gorham JM, McKean DM, DePalma SR, Bernstein D, Brueckner M, Chung WK, Giardini A, Goldmuntz E, Kaltman JR, Kim R, Newburger JW, Shen Y, Srivastava D, Tristani-Firouzi M, Gelb BD, Porter GA Jr, Seidman CE, Seidman JG. Circ Genom Precis Med. 2023 Jun; 2023 May 11. PMID: 37165897.", + "Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease. Mishra-Gorur K, Barak T, Kaulen LD, Henegariu O, Jin SC, Aguilera SM, Yalbir E, Goles G, Nishimura S, Miyagishima D, Djenoune L, Altinok S, Rai DK, Viviano S, Prendergast A, Zerillo C, Ozcan K, Baran B, Sencar L, Goc N, Yarman Y, Ercan-Sencicek AG, Bilguvar K, Lifton RP, Moliterno J, Louvi A, Yuan S, Deniz E, Brueckner M, Gunel M. Proc Natl Acad Sci U S A. 2023 Apr 18; 2023 Apr 12. PMID: 37043537.", + "Association of Predicted Damaging De Novo Variants on Ventricular Function in Individuals With Congenital Heart Disease. Lewis MJ, Hsieh A, Qiao L, Tan R, Kazzi B, Channing A, Griffin EL, Jobanputra V, Su J, Shahryar C, Kochilas L, Gaynor JW, Lee T, Goldmuntz E, Russell M, Mital S, Tristani M, Brueckner M, Newburger J, Shen Y, Chung WK. Circ Genom Precis Med. 2023 Apr; 2023 Mar 3. PMID: 36866680.", + "Evidence-Based Assessment of Congenital Heart Disease Genes to Enable Returning Results in a Genomic Study. Griffin EL, Nees SN, Morton SU, Wynn J, Patel N, Jobanputra V, Robinson S, Kochav SM, Tao A, Andrews C, Cross N, Geva J, Lanzilotta K, Ritter A, Taillie E, Thompson A, Meyer C, Akers R, King EC, Cnota JF, Kim RW, Porter GA Jr, Brueckner M, Seidman CE, Shen Y, Gelb BD, Goldmuntz E, Newburger JW, Roberts AE, Chung WK. Circ Genom Precis Med. 2023 Apr; 2023 Feb 21. PMID: 36803080.", + "Inactivation of Invs/Nphp2 in renal epithelial cells drives infantile nephronophthisis like phenotypes in mouse. Li Y, Xu W, Makova S, Brueckner M, Sun Z. Elife. 2023 Mar 15; 2023 Mar 15. PMID: 36920028.", + "Cilia function as calcium-mediated mechanosensors that instruct left-right asymmetry. Djenoune L, Mahamdeh M, Truong TV, Nguyen CT, Fraser SE, Brueckner M, Howard J, Yuan S. Science. 2023 Jan 6; 2023 Jan 5. PMID: 36603098.", + "Association of Potentially Damaging De Novo Gene Variants With Neurologic Outcomes in Congenital Heart Disease. Morton SU, Norris-Brilliant A, Cunningham S, King E, Goldmuntz E, Brueckner M, Miller TA, Thomas NH, Liu C, Adams HR, Bellinger DC, Cleveland J, Cnota JF, Dale AM, Frommelt M, Gelb BD, Grant PE, Goldberg CS, Huang H, Kuperman JM, Li JS, McQuillen PS, Panigrahy A, Porter GA Jr, Roberts AE, Russell MW, Seidman CE, Tivarus ME, Anagnoustou E, Hagler DJ Jr, Chung WK, Newburger JW. JAMA Netw Open. 2023 Jan 3; 2023 Jan 3. PMID: 36701153.", + "Network assisted analysis of de novo variants using protein-protein interaction information identified 46 candidate genes for congenital heart disease. Xie Y, Jiang W, Dong W, Li H, Jin SC, Brueckner M, Zhao H. PLoS Genet. 2022 Jun; 2022 Jun 7. PMID: 35671298.", + "Quantifying concordant genetic effects of de novo mutations on multiple disorders. Guo H, Hou L, Shi Y, Jin SC, Zeng X, Li B, Lifton RP, Brueckner M, Zhao H, Lu Q. Elife. 2022 Jun 6; 2022 Jun 6. PMID: 35666111.", + "Mutation spectrum of congenital heart disease in a consanguineous Turkish population. Dong W, Kaymakcalan H, Jin SC, Diab NS, Tanıdır C, Yalcin ASY, Ercan-Sencicek AG, Mane S, Gunel M, Lifton RP, Bilguvar K, Brueckner M. Mol Genet Genomic Med. 2022 Jun; 2022 Apr 28. PMID: 35481623.", + "Neither cardiac mitochondrial DNA variation nor copy number contribute to congenital heart disease risk. Willcox JAL, Geiger JT, Morton SU, McKean D, Quiat D, Gorham JM, Tai AC, DePalma S, Bernstein D, Brueckner M, Chung WK, Giardini A, Goldmuntz E, Kaltman JR, Kim R, Newburger JW, Shen Y, Srivastava D, Tristani-Firouzi M, Gelb B, Porter GA Jr, Seidman JG, Seidman CE. Am J Hum Genet. 2022 May 5; 2022 Apr 8. PMID: 35397206.", + "Genome-Wide De Novo Variants in Congenital Heart Disease Are Not Associated With Maternal Diabetes or Obesity. Morton SU, Pereira AC, Quiat D, Richter F, Kitaygorodsky A, Hagen J, Bernstein D, Brueckner M, Goldmuntz E, Kim RW, Lifton RP, Porter GA Jr, Tristani-Firouzi M, Chung WK, Roberts A, Gelb BD, Shen Y, Newburger JW, Seidman JG, Seidman CE. Circ Genom Precis Med. 2022 Apr; 2022 Feb 7. PMID: 35130025.", + "A change of heart: new roles for cilia in cardiac development and disease. Djenoune L, Berg K, Brueckner M, Yuan S. Nat Rev Cardiol. 2022 Apr; 2021 Dec 3. PMID: 34862511.", + "Molecular Genetics and Complex Inheritance of Congenital Heart Disease. Diab NS, Barish S, Dong W, Zhao S, Allington G, Yu X, Kahle KT, Brueckner M, Jin SC. Genes (Basel). 2021 Jun 30; 2021 Jun 30. PMID: 34209044.", + "Integrative modeling of transmitted and de novo variants identifies novel risk genes for congenital heart disease. Li M, Zeng X, Jin C, Jin SC, Dong W, Brueckner M, Lifton R, Lu Q, Zhao H. Quant Biol. 2021 Jun. PMID: 35414959.", + "Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency. Ward T, Tai W, Morton S, Impens F, Van Damme P, Van Haver D, Timmerman E, Venturini G, Zhang K, Jang MY, Willcox JAL, Haghighi A, Gelb BD, Chung WK, Goldmuntz E, Porter GA Jr, Lifton RP, Brueckner M, Yost HJ, Bruneau BG, Gorham J, Kim Y, Pereira A, Homsy J, Benson CC, DePalma SR, Varland S, Chen CS, Arnesen T, Gevaert K, Seidman C, Seidman JG. Circ Res. 2021 Apr 16; 2021 Feb 9. PMID: 33557580.", + "Association of Damaging Variants in Genes With Increased Cancer Risk Among Patients With Congenital Heart Disease. Morton SU, Shimamura A, Newburger PE, Opotowsky AR, Quiat D, Pereira AC, Jin SC, Gurvitz M, Brueckner M, Chung WK, Shen Y, Bernstein D, Gelb BD, Giardini A, Goldmuntz E, Kim RW, Lifton RP, Porter GA Jr, Srivastava D, Tristani-Firouzi M, Newburger JW, Seidman JG, Seidman CE. JAMA Cardiol. 2021 Apr 1. PMID: 33084842.", + "De Novo Damaging Variants, Clinical Phenotypes, and Post-Operative Outcomes in Congenital Heart Disease. Boskovski MT, Homsy J, Nathan M, Sleeper LA, Morton S, Manheimer KB, Tai A, Gorham J, Lewis M, Swartz M, Alfieris GM, Bacha EA, Karimi M, Meyer D, Nguyen K, Bernstein D, Romano-Adesman A, Porter GA Jr, Goldmuntz E, Chung WK, Srivastava D, Kaltman JR, Tristani-Firouzi M, Lifton R, Roberts AE, Gaynor JW, Gelb BD, Kim R, Seidman JG, Brueckner M, Mayer JE Jr, Newburger JW, Seidman CE. Circ Genom Precis Med. 2020 Aug; 2020 Jun 30. PMID: 32812804.", + "Genomic analyses implicate noncoding de novo variants in congenital heart disease. Richter F, Morton SU, Kim SW, Kitaygorodsky A, Wasson LK, Chen KM, Zhou J, Qi H, Patel N, DePalma SR, Parfenov M, Homsy J, Gorham JM, Manheimer KB, Velinder M, Farrell A, Marth G, Schadt EE, Kaltman JR, Newburger JW, Giardini A, Goldmuntz E, Brueckner M, Kim R, Porter GA Jr, Bernstein D, Chung WK, Srivastava D, Tristani-Firouzi M, Troyanskaya OG, Dickel DE, Shen Y, Seidman JG, Seidman CE, Gelb BD. Nat Genet. 2020 Aug; 2020 Jun 29. PMID: 32601476.", + "EM-mosaic detects mosaic point mutations that contribute to congenital heart disease. Hsieh A, Morton SU, Willcox JAL, Gorham JM, Tai AC, Qi H, DePalma S, McKean D, Griffin E, Manheimer KB, Bernstein D, Kim RW, Newburger JW, Porter GA Jr, Srivastava D, Tristani-Firouzi M, Brueckner M, Lifton RP, Goldmuntz E, Gelb BD, Chung WK, Seidman CE, Seidman JG, Shen Y. Genome Med. 2020 Apr 29; 2020 Apr 29. PMID: 32349777.", + "De novo damaging variants associated with congenital heart diseases contribute to the connectome. Ji W, Ferdman D, Copel J, Scheinost D, Shabanova V, Brueckner M, Khokha MK, Ment LR. Sci Rep. 2020 Apr 27; 2020 Apr 27. PMID: 32341405.", + "Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. Edwards JJ, Rouillard AD, Fernandez NF, Wang Z, Lachmann A, Shankaran SS, Bisgrove BW, Demarest B, Turan N, Srivastava D, Bernstein D, Deanfield J, Giardini A, Porter G, Kim R, Roberts AE, Newburger JW, Goldmuntz E, Brueckner M, Lifton RP, Seidman CE, Chung WK, Tristani-Firouzi M, Yost HJ, Ma'ayan A, Gelb BD. JACC Basic Transl Sci. 2020 Apr; 2020 Apr 8. PMID: 32368696.", + "De novo and recessive forms of congenital heart disease have distinct genetic and phenotypic landscapes. Watkins WS, Hernandez EJ, Wesolowski S, Bisgrove BW, Sunderland RT, Lin E, Lemmon G, Demarest BL, Miller TA, Bernstein D, Brueckner M, Chung WK, Gelb BD, Goldmuntz E, Newburger JW, Seidman CE, Shen Y, Yost HJ, Yandell M, Tristani-Firouzi M. Nat Commun. 2019 Oct 17; 2019 Oct 17. PMID: 31624253.", + "Histone H2B monoubiquitination regulates heart development via epigenetic control of cilia motility. Robson A, Makova SZ, Barish S, Zaidi S, Mehta S, Drozd J, Jin SC, Gelb BD, Seidman CE, Chung WK, Lifton RP, Khokha MK, Brueckner M. Proc Natl Acad Sci U S A. 2019 Jul 9; 2019 Jun 24. PMID: 31235600.", + "Robust identification of deletions in exome and genome sequence data based on clustering of Mendelian errors. Manheimer KB, Patel N, Richter F, Gorham J, Tai AC, Homsy J, Boskovski MT, Parfenov M, Goldmuntz E, Chung WK, Brueckner M, Tristani-Firouzi M, Srivastava D, Seidman JG, Seidman CE, Gelb BD, Sharp AJ. Hum Mutat. 2018 Jun; 2018 Mar 22. PMID: 29527824.", + "NUP98 Sets the Size-Exclusion Diffusion Limit through the Ciliary Base. Endicott SJ, Brueckner M. Curr Biol. 2018 May 21; 2018 May 3. PMID: 29731308.", + "Left-Right Asymmetry: Myosin 1D at the Center. Yuan S, Brueckner M. Curr Biol. 2018 May 7. PMID: 29738734.", + "Robust identification of mosaic variants in congenital heart disease. Manheimer KB, Richter F, Edelmann LJ, D'Souza SL, Shi L, Shen Y, Homsy J, Boskovski MT, Tai AC, Gorham J, Yasso C, Goldmuntz E, Brueckner M, Lifton RP, Chung WK, Seidman CE, Seidman JG, Gelb BD. Hum Genet. 2018 Feb; 2018 Feb 7. PMID: 29417219.", + "The Congenital Heart Disease Genetic Network Study: Cohort description. Hoang TT, Goldmuntz E, Roberts AE, Chung WK, Kline JK, Deanfield JE, Giardini A, Aleman A, Gelb BD, Mac Neal M, Porter GA Jr, Kim R, Brueckner M, Lifton RP, Edman S, Woyciechowski S, Mitchell LE, Agopian AJ. PLoS One. 2018; 2018 Jan 19. PMID: 29351346.", + "Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands. Jin SC, Homsy J, Zaidi S, Lu Q, Morton S, DePalma SR, Zeng X, Qi H, Chang W, Sierant MC, Hung WC, Haider S, Zhang J, Knight J, Bjornson RD, Castaldi C, Tikhonoa IR, Bilguvar K, Mane SM, Sanders SJ, Mital S, Russell MW, Gaynor JW, Deanfield J, Giardini A, Porter GA Jr, Srivastava D, Lo CW, Shen Y, Watkins WS, Yandell M, Yost HJ, Tristani-Firouzi M, Newburger JW, Roberts AE, Kim R, Zhao H, Kaltman JR, Goldmuntz E, Chung WK, Seidman JG, Gelb BD, Seidman CE, Lifton RP, Brueckner M. Nat Genet. 2017 Nov; 2017 Oct 9. PMID: 28991257.", + "The genetics of congenital heart disease… understanding and improving long-term outcomes in congenital heart disease: a review for the general cardiologist and primary care physician. Simmons MA, Brueckner M. Curr Opin Pediatr. 2017 Oct. PMID: 28872494.", + "Genetics and Genomics of Congenital Heart Disease. Zaidi S, Brueckner M. Circ Res. 2017 Mar 17. PMID: 28302740.", + "Loss of RNA expression and allele-specific expression associated with congenital heart disease. McKean DM, Homsy J, Wakimoto H, Patel N, Gorham J, DePalma SR, Ware JS, Zaidi S, Ma W, Patel N, Lifton RP, Chung WK, Kim R, Shen Y, Brueckner M, Goldmuntz E, Sharp AJ, Seidman CE, Gelb BD, Seidman JG. Nat Commun. 2016 Sep 27; 2016 Sep 27. PMID: 27670201.", + "DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes. Dougherty GW, Loges NT, Klinkenbusch JA, Olbrich H, Pennekamp P, Menchen T, Raidt J, Wallmeier J, Werner C, Westermann C, Ruckert C, Mirra V, Hjeij R, Memari Y, Durbin R, Kolb-Kokocinski A, Praveen K, Kashef MA, Kashef S, Eghtedari F, Häffner K, Valmari P, Baktai G, Aviram M, Bentur L, Amirav I, Davis EE, Katsanis N, Brueckner M, Shaposhnykov A, Pigino G, Dworniczak B, Omran H. Am J Respir Cell Mol Biol. 2016 Aug. PMID: 26909801.", + "Visualization and Manipulation of Cilia and Intraciliary Calcium in the Zebrafish Left-Right Organizer. Yuan S, Brueckner M. Methods Mol Biol. 2016. PMID: 27514920.", + "De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies. Homsy J, Zaidi S, Shen Y, Ware JS, Samocha KE, Karczewski KJ, DePalma SR, McKean D, Wakimoto H, Gorham J, Jin SC, Deanfield J, Giardini A, Porter GA Jr, Kim R, Bilguvar K, López-Giráldez F, Tikhonova I, Mane S, Romano-Adesman A, Qi H, Vardarajan B, Ma L, Daly M, Roberts AE, Russell MW, Mital S, Newburger JW, Gaynor JW, Breitbart RE, Iossifov I, Ronemus M, Sanders SJ, Kaltman JR, Seidman JG, Brueckner M, Gelb BD, Goldmuntz E, Lifton RP, Seidman CE, Chung WK. Science. 2015 Dec 4. PMID: 26785492.", + "The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry. Endicott SJ, Basu B, Khokha M, Brueckner M. Development. 2015 Dec 1; 2015 Oct 22. PMID: 26493400.", + "Intraciliary calcium oscillations initiate vertebrate left-right asymmetry. Yuan S, Zhao L, Brueckner M, Sun Z. Curr Biol. 2015 Mar 2; 2015 Feb 5. PMID: 25660539.", + "Increased frequency of de novo copy number variants in congenital heart disease by integrative analysis of single nucleotide polymorphism array and exome sequence data. Glessner JT, Bick AG, Ito K, Homsy J, Rodriguez-Murillo L, Fromer M, Mazaika E, Vardarajan B, Italia M, Leipzig J, DePalma SR, Golhar R, Sanders SJ, Yamrom B, Ronemus M, Iossifov I, Willsey AJ, State MW, Kaltman JR, White PS, Shen Y, Warburton D, Brueckner M, Seidman C, Goldmuntz E, Gelb BD, Lifton R, Seidman J, Hakonarson H, Chung WK. Circ Res. 2014 Oct 24; 2014 Sep 9. PMID: 25205790.", + "CANOES: detecting rare copy number variants from whole exome sequencing data. Backenroth D, Homsy J, Murillo LR, Glessner J, Lin E, Brueckner M, Lifton R, Goldmuntz E, Chung WK, Shen Y. Nucleic Acids Res. 2014 Jul; 2014 Apr 25. PMID: 24771342.", + "The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality. Boskovski MT, Yuan S, Pedersen NB, Goth CK, Makova S, Clausen H, Brueckner M, Khokha MK. Nature. 2013 Dec 19; 2013 Nov 13. PMID: 24226769.", + "De novo mutations in histone-modifying genes in congenital heart disease. Zaidi S, Choi M, Wakimoto H, Ma L, Jiang J, Overton JD, Romano-Adesman A, Bjornson RD, Breitbart RE, Brown KK, Carriero NJ, Cheung YH, Deanfield J, DePalma S, Fakhro KA, Glessner J, Hakonarson H, Italia MJ, Kaltman JR, Kaski J, Kim R, Kline JK, Lee T, Leipzig J, Lopez A, Mane SM, Mitchell LE, Newburger JW, Parfenov M, Pe'er I, Porter G, Roberts AE, Sachidanandam R, Sanders SJ, Seiden HS, State MW, Subramanian S, Tikhonova IR, Wang W, Warburton D, White PS, Williams IA, Zhao H, Seidman JG, Brueckner M, Chung WK, Gelb BD, Goldmuntz E, Seidman CE, Lifton RP. Nature. 2013 Jun 13; 2013 May 12. PMID: 23665959.", + "Congenital heart disease: emerging themes linking genetics and development. Yuan S, Zaidi S, Brueckner M. Curr Opin Genet Dev. 2013 Jun; 2013 Jun 20. PMID: 23790954.", + "Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning. Fakhro KA, Choi M, Ware SM, Belmont JW, Towbin JA, Lifton RP, Khokha MK, Brueckner M. Proc Natl Acad Sci U S A. 2011 Feb 15; 2011 Jan 31. PMID: 21282601.", + "Fibroblast \"cilia growth\" factor in the development of left-right asymmetry. Basu B, Brueckner M. Dev Cell. 2009 Apr. PMID: 19386257.", + "Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis. Slough J, Cooney L, Brueckner M. Dev Dyn. 2008 Sep. PMID: 18729223.", + "Microvillus inclusion disease associated with coarctation of the aorta and bicuspid aortic valve. Gathungu GN, Pashankar DS, Sarita-Reyes CD, Zambrano E, Reyes-Mugica M, Brueckner M, Mistry PK, Husain SZ. J Clin Gastroenterol. 2008 Apr. PMID: 18277898.", + "Cilia multifunctional organelles at the center of vertebrate left-right asymmetry. Basu B, Brueckner M. Curr Top Dev Biol. 2008. PMID: 19147005.", + "Outcomes after a Ladd procedure for intestinal malrotation with heterotaxia. Tashjian DB, Weeks B, Brueckner M, Touloukian RJ. J Pediatr Surg. 2007 Mar. PMID: 17336193.", + "Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. Cooper AF, Yu KP, Brueckner M, Brailey LL, Johnson L, McGrath JM, Bale AE. Development. 2005 Oct. PMID: 16155214.", + "A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels. Hallaq H, Pinter E, Enciso J, McGrath J, Zeiss C, Brueckner M, Madri J, Jacobs HC, Wilson CM, Vasavada H, Jiang X, Bogue CW. Development. 2004 Oct. PMID: 15459110.", + "What comes first: the structure or the egg? Ross Granville Harrison on the origin of embryonic polarity. Brueckner M. J Exp Zool A Comp Exp Biol. 2004 Jul 1. PMID: 15229864.", + "Cilia are at the heart of vertebrate left-right asymmetry. McGrath J, Brueckner M. Curr Opin Genet Dev. 2003 Aug. PMID: 12888012.", + "Two populations of node monocilia initiate left-right asymmetry in the mouse. McGrath J, Somlo S, Makova S, Tian X, Brueckner M. Cell. 2003 Jul 11. PMID: 12859898.", + "Cilia propel the embryo in the right direction. Brueckner M. Am J Med Genet. 2001 Jul 15. PMID: 11471157.", + "Of mice and men: dissecting the genetic pathway that controls left-right asymmetry in mice and humans. Schneider H, Brueckner M. Am J Med Genet. 2000 Winter. PMID: 11376437.", + "GATA4 haploinsufficiency in patients with interstitial deletion of chromosome region 8p23.1 and congenital heart disease. Pehlivan T, Pober BR, Brueckner M, Garrett S, Slaugh R, Van Rheeden R, Wilson DB, Watson MS, Hing AV. Am J Med Genet. 1999 Mar 19. PMID: 10096597.", + "The genetics of left-right development and heterotaxia. Bowers PN, Brueckner M, Yost HJ. Semin Perinatol. 1996 Dec. PMID: 9090782.", + "Isolation of murine telomere-proximal sequences by affinity capture and PCR. Rounds D, Brueckner M, Ward DC. Genomics. 1995 Oct 10. PMID: 8575753.", + "Intestinal rotation and fixation abnormalities in heterotaxia: early detection and management. Chang J, Brueckner M, Touloukian RJ. J Pediatr Surg. 1993 Oct. PMID: 8263687.", + "Genetic aspects of heart disease in the newborn. Bulbul ZR, Rosenthal D, Brueckner M. Semin Perinatol. 1993 Apr. PMID: 8327904.", + "Neonatal correction of transposition of the great arteries: the Connecticut experience. Dewar ML, Kleinman C, Hellenbrand W, Fahey J, Talner N, Brueckner M, Kopf GS. Conn Med. 1992 Dec. PMID: 1288934.", + "Duplication/deficiency mapping of situs inversus viscerum (iv), a gene that determines left-right asymmetry in the mouse. McGrath J, Horwich AL, Brueckner M. Genomics. 1992 Nov. PMID: 1427890.", + "Establishment of left-right asymmetry in vertebrates: genetically distinct steps are involved. Brueckner M, McGrath J, D'Eustachio P, Horwich AL. Ciba Found Symp. 1991. PMID: 1802643.", + "Linkage mapping of a mouse gene, iv, that controls left-right asymmetry of the heart and viscera. Brueckner M, D'Eustachio P, Horwich AL. Proc Natl Acad Sci U S A. 1989 Jul. PMID: 2740340.", + "Fitkin Memorial Pavilion 789 Howard Avenue New Haven, CT 06510", + "1 Event you could attend in November 2025 Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Bruscia Lab", + "lab_url": "https://medicine.yale.edu/lab/bruscia/", + "research_bio": "INFORMATION FOR My lab has a longstanding interest in cystic fibrosis (CF), a recessive genetic multiorgan disease that affects the lung, gut, pancreas, liver, and reproductive tissues. We investigate how a specific group of immune cells, the monocytes and the macrophages, contributes to the overwhelming inflammation, the inefficient host defense against bacteria and the altered lung tissue repair processes that characterize CF lung disease. Ultimately, we aim to identify potential mechanism-based therapeutic targets that, in conjunction with the current CFTR modulator therapies, will help prevent progressive lung tissue deterioration in CF patients. In our preclinical investigations we use CF patients’ biological specimens, CF mouse models, and CF primary and immortalized cells. We closely collaborate with the CF Center at Yale New Haven Hospital, and with multiples investigators at Yale and around the country. We use intradisciplinary methodologies that bridge the lung immunology and hematopoietic stem cell fields to address unexplored questions related to the contribution of altered immunity to the progression of lung disease in CF. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/bruscia/publications/", + "publications": [ + "Yale School of Medicine /", + "Pediatrics /", + "Research", + "Lab Members", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Lab Members", + "Publications", + "News", + "", + "", + "", + "", + "", + "", + "Prevalence and phenotype of food allergy in children with cystic fibrosis. Nguyen HP, Shabanova V, McCollum S, Polk B, Lee T, Whittington K, Cunha P, Bruscia EM, Egan ME, Emmenegger M, Leeds S. Ann Allergy Asthma Immunol. 2025 Oct; 2025 Jun 21. PMID: 40550267.", + "ENaC contributes to macrophage dysfunction in cystic fibrosis. Moran J, Pugh C, Brown N, Thomas A, Zhang S, McCauley E, Cephas A, Shrestha CL, Partida-Sanchez S, Bai S, Bruscia E, Kopp BT. Am J Physiol Lung Cell Mol Physiol. 2025 Jul 1; 2025 Jun 2. PMID: 40454714.", + "CCR2+ monocytes are dispensable to resolve acute pulmonary Pseudomonas aeruginosa infections in WT and cystic fibrosis mice. Öz HH, Braga CL, Gudneppanavar R, Di Pietro C, Huang PH, Zhang PX, Krause DS, Egan ME, Murray TS, Bruscia EM. J Leukoc Biol. 2025 Mar 14. PMID: 39365279.", + "CFTR dictates monocyte adhesion by facilitating integrin clustering but not activation. Younis DA, Marosvari M, Liu W, Pulikkot S, Cao Z, Zhou B, Vella AT, McArdle S, Hu L, Chen Y, Gan W, Yu J, Bruscia EM, Fan Z. Proc Natl Acad Sci U S A. 2025 Jan 21; 2025 Jan 15. PMID: 39813254.", + "Ezrin drives adaptation of monocytes to the inflamed lung microenvironment. Gudneppanavar R, Di Pietro C, H Öz H, Zhang PX, Cheng EC, Huang PH, Tebaldi T, Biancon G, Halene S, Hoppe AD, Kim C, Gonzalez AL, Krause DS, Egan ME, Gupta N, Murray TS, Bruscia EM. Cell Death Dis. 2024 Nov 29; 2024 Nov 29. PMID: 39613751.", + "ENaC contributes to macrophage dysfunction in cystic fibrosis. Moran J, Pugh C, Brown N, Thomas A, Zhang S, McCauley E, Cephas A, Shrestha CL, Partida-Sanchez S, Bai S, Bruscia E, Kopp BT. bioRxiv. 2024 Nov 8; 2024 Nov 8. PMID: 39574739.", + "Prior Influenza Infection Mitigates SARS-CoV-2 Disease in Syrian Hamsters. Di Pietro C, Haberman AM, Lindenbach BD, Smith PC, Bruscia EM, Allore HG, Vander Wyk B, Tyagi A, Zeiss CJ. Viruses. 2024 Feb 3; 2024 Feb 3. PMID: 38400021.", + "The effects of elexafactor/tezafactor/ivacaftor beyond the epithelium: spurring macrophages to fight infections. Bruscia EM. Eur Respir J. 2023 Apr; 2023 Apr 1. PMID: 37003613.", + "Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis. Öz HH, Cheng EC, Di Pietro C, Tebaldi T, Biancon G, Zeiss C, Zhang PX, Huang PH, Esquibies SS, Britto CJ, Schupp JC, Murray TS, Halene S, Krause DS, Egan ME, Bruscia EM. Cell Rep. 2022 Dec 13. PMID: 36516754.", + "Update on Innate and Adaptive Immunity in Cystic Fibrosis. Bruscia EM, Bonfield TL. Clin Chest Med. 2022 Dec. PMID: 36344069.", + "Human neutrophil development and functionality are enabled in a humanized mouse model. Zheng Y, Sefik E, Astle J, Karatepe K, Öz HH, Solis AG, Jackson R, Luo HR, Bruscia EM, Halene S, Shan L, Flavell RA. Proc Natl Acad Sci U S A. 2022 Oct 25; 2022 Oct 21. PMID: 36269862.", + "Emerging Concepts in Defective Macrophage Phagocytosis in Cystic Fibrosis. Jaganathan D, Bruscia EM, Kopp BT. Int J Mol Sci. 2022 Jul 13; 2022 Jul 13. PMID: 35887098.", + "Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosis. Di Pietro C, Öz HH, Zhang PX, Cheng EC, Martis V, Bonfield TL, Kelley TJ, Jubin R, Abuchowski A, Krause DS, Egan ME, Murray TS, Bruscia EM. Exp Mol Med. 2022 May; 2022 May 17. PMID: 35581352.", + "Combined liver-cytokine humanization comes to the rescue of circulating human red blood cells. Song Y, Shan L, Gbyli R, Liu W, Strowig T, Patel A, Fu X, Wang X, Xu ML, Gao Y, Qin A, Bruscia EM, Tebaldi T, Biancon G, Mamillapalli P, Urbonas D, Eynon E, Gonzalez DG, Chen J, Krause DS, Alderman J, Halene S, Flavell RA. Science. 2021 Mar 5. PMID: 33674488.", + "Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis. Schupp JC, Khanal S, Gomez JL, Sauler M, Adams TS, Chupp GL, Yan X, Poli S, Zhao Y, Montgomery RR, Rosas IO, Dela Cruz CS, Bruscia EM, Egan ME, Kaminski N, Britto CJ. Am J Respir Crit Care Med. 2020 Nov 15. PMID: 32603604.", + "Targeting the Heme Oxygenase 1/Carbon Monoxide Pathway to Resolve Lung Hyper-Inflammation and Restore a Regulated Immune Response in Cystic Fibrosis. Di Pietro C, Öz HH, Murray TS, Bruscia EM. Front Pharmacol. 2020; 2020 Jul 14. PMID: 32760278.", + "A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies. Song Y, Rongvaux A, Taylor A, Jiang T, Tebaldi T, Balasubramanian K, Bagale A, Terzi YK, Gbyli R, Wang X, Fu X, Gao Y, Zhao J, Podoltsev N, Xu M, Neparidze N, Wong E, Torres R, Bruscia EM, Kluger Y, Manz MG, Flavell RA, Halene S. Nat Commun. 2019 Jan 21; 2019 Jan 21. PMID: 30664659.", + "Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair. Jin H, Ciechanowicz AK, Kaplan AR, Wang L, Zhang PX, Lu YC, Tobin RE, Tobin BA, Cohn L, Zeiss CJ, Lee PJ, Bruscia EM, Krause DS. Am J Physiol Lung Cell Mol Physiol. 2018 May 1; 2018 Jan 18. PMID: 29345196.", + "Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages. Di Pietro C, Zhang PX, O'Rourke TK, Murray TS, Wang L, Britto CJ, Koff JL, Krause DS, Egan ME, Bruscia EM. Sci Rep. 2017 Sep 7; 2017 Sep 7. PMID: 28883468.", + "Cellular Innate Immunity: An Old Game with New Players. Gasteiger G, D'Osualdo A, Schubert DA, Weber A, Bruscia EM, Hartl D. J Innate Immun. 2017; 2016 Dec 23. PMID: 28006777.", + "Increased susceptibility of Cftr-/- mice to LPS-induced lung remodeling. Bruscia EM, Zhang PX, Barone C, Scholte BJ, Homer R, Krause DS, Egan ME. Am J Physiol Lung Cell Mol Physiol. 2016 Apr 15; 2016 Feb 5. PMID: 26851259.", + "Innate and Adaptive Immunity in Cystic Fibrosis. Bruscia EM, Bonfield TL. Clin Chest Med. 2016 Mar; 2015 Dec 28. PMID: 26857765.", + "Cystic Fibrosis Lung Immunity: The Role of the Macrophage. Bruscia EM, Bonfield TL. J Innate Immun. 2016; 2016 Jun 24. PMID: 27336915.", + "Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation. Zhang PX, Cheng J, Zou S, D'Souza AD, Koff JL, Lu J, Lee PJ, Krause DS, Egan ME, Bruscia EM. Nat Commun. 2015 Feb 10; 2015 Feb 10. PMID: 25665524.", + "SRF is required for neutrophil migration in response to inflammation. Taylor A, Tang W, Bruscia EM, Zhang PX, Lin A, Gaines P, Wu D, Halene S. Blood. 2014 May 8; 2014 Feb 26. PMID: 24574460.", + "Very small embryonic-like stem cells from the murine bone marrow differentiate into epithelial cells of the lung. Kassmer SH, Jin H, Zhang PX, Bruscia EM, Heydari K, Lee JH, Kim CF, Kassmer SH, Krause DS. Stem Cells. 2013 Dec. PMID: 23681901.", + "Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator. Villella VR, Esposito S, Bruscia EM, Vicinanza M, Cenci S, Guido S, Pettoello-Mantovani M, Carnuccio R, De Matteis MA, Luini A, Maiuri MC, Raia V, Kroemer G, Maiuri L. Cell Death Differ. 2013 Aug; 2013 May 17. PMID: 23686137.", + "Nebulized hyaluronan ameliorates lung inflammation in cystic fibrosis mice. Gavina M, Luciani A, Villella VR, Esposito S, Ferrari E, Bressani I, Casale A, Bruscia EM, Maiuri L, Raia V. Pediatr Pulmonol. 2013 Aug; 2012 Jul 23. PMID: 22825912.", + "Reduced caveolin-1 promotes hyperinflammation due to abnormal heme oxygenase-1 localization in lipopolysaccharide-challenged macrophages with dysfunctional cystic fibrosis transmembrane conductance regulator. Zhang PX, Murray TS, Villella VR, Ferrari E, Esposito S, D'Souza A, Raia V, Maiuri L, Krause DS, Egan ME, Bruscia EM. J Immunol. 2013 May 15; 2013 Apr 19. PMID: 23606537.", + "Targeting the Intracellular Environment in Cystic Fibrosis: Restoring Autophagy as a Novel Strategy to Circumvent the CFTR Defect. Villella VR, Esposito S, Bruscia EM, Maiuri MC, Raia V, Kroemer G, Maiuri L. Front Pharmacol. 2013; 2013 Jan 21. PMID: 23346057.", + "Nonhematopoietic cells are the primary source of bone marrow-derived lung epithelial cells. Kassmer SH, Bruscia EM, Zhang PX, Krause DS. Stem Cells. 2012 Mar. PMID: 22162244.", + "The carbon monoxide releasing molecule CORM-2 attenuates Pseudomonas aeruginosa biofilm formation. Murray TS, Okegbe C, Gao Y, Kazmierczak BI, Motterlini R, Dietrich LE, Bruscia EM. PLoS One. 2012; 2012 Apr 26. PMID: 22563385.", + "Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. Bruscia EM, Zhang PX, Satoh A, Caputo C, Medzhitov R, Shenoy A, Egan ME, Krause DS. J Immunol. 2011 Jun 15; 2011 May 18. PMID: 21593379.", + "Role for MKL1 in megakaryocytic maturation. Cheng EC, Luo Q, Bruscia EM, Renda MJ, Troy JA, Massaro SA, Tuck D, Schulz V, Mane SM, Berliner N, Sun Y, Morris SW, Qiu C, Krause DS. Blood. 2009 Mar 19; 2009 Jan 9. PMID: 19136660.", + "Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice. Bruscia EM, Zhang PX, Ferreira E, Caputo C, Emerson JW, Tuck D, Krause DS, Egan ME. Am J Respir Cell Mol Biol. 2009 Mar; 2008 Sep 5. PMID: 18776130.", + "Rectal potential difference and the functional expression of CFTR in the gastrointestinal epithelia in cystic fibrosis mouse models. Weiner SA, Caputo C, Bruscia E, Ferreira EC, Price JE, Krause DS, Egan ME. Pediatr Res. 2008 Jan. PMID: 18043508.", + "Cftr gene targeting in mouse embryonic stem cells mediated by Small Fragment Homologous Replacement (SFHR). Sangiuolo F, Scaldaferri ML, Filareto A, Spitalieri P, Guerra L, Favia M, Caroppo R, Mango R, Bruscia E, Gruenert DC, Casavola V, De Felici M, Novelli G. Front Biosci. 2008 Jan 1; 2008 Jan 1. PMID: 17981772.", + "Engraftment of donor-derived epithelial cells in multiple organs following bone marrow transplantation into newborn mice. Bruscia EM, Ziegler EC, Price JE, Weiner S, Egan ME, Krause DS. Stem Cells. 2006 Oct; 2006 Jun 22. PMID: 16794262.", + "Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation. Bruscia EM, Price JE, Cheng EC, Weiner S, Caputo C, Ferreira EC, Egan ME, Krause DS. Proc Natl Acad Sci U S A. 2006 Feb 21; 2006 Feb 15. PMID: 16481627.", + "In vitro restoration of functional SMN protein in human trophoblast cells affected by spinal muscular atrophy by small fragment homologous replacement. Sangiuolo F, Filareto A, Spitalieri P, Scaldaferri ML, Mango R, Bruscia E, Citro G, Brunetti E, De Felici M, Novelli G. Hum Gene Ther. 2005 Jul. PMID: 16000068.", + "Engraftment of bone marrow-derived epithelial cells. Van Arnam JS, Herzog E, Grove J, Bruscia E, Ziegler E, Swenson S, Krause DS. Stem Cell Rev. 2005. PMID: 17132871.", + "Lack of a fusion requirement for development of bone marrow-derived epithelia. Harris RG, Herzog EL, Bruscia EM, Grove JE, Van Arnam JS, Krause DS. Science. 2004 Jul 2. PMID: 15232107.", + "Oligonucleotide-based gene targeting approaches. Gruenert DC, Kunzelmann K, Novelli G, Colosimo A, Kapsa R, Bruscia E. Oligonucleotides. 2004. PMID: 15294078.", + "Plasticity of bone marrow-derived stem cells. Grove JE, Bruscia E, Krause DS. Stem Cells. 2004. PMID: 15277695.", + "Sequence-specific modification of genomic DNA by small DNA fragments. Gruenert DC, Bruscia E, Novelli G, Colosimo A, Dallapiccola B, Sangiuolo F, Goncz KK. J Clin Invest. 2003 Sep. PMID: 12952908.", + "In vitro correction of cystic fibrosis epithelial cell lines by small fragment homologous replacement (SFHR) technique. Sangiuolo F, Bruscia E, Serafino A, Nardone AM, Bonifazi E, Lais M, Gruenert DC, Novelli G. BMC Med Genet. 2002 Sep 23; 2002 Sep 23. PMID: 12243649.", + "Towards the pharmacogenomics of cystic fibrosis. Sangiuolo F, D'Apice MR, Bruscia E, Lucidi V, Novelli G. Pharmacogenomics. 2002 Jan. PMID: 11966405.", + "Hartl D, Gaggar A, Bruscia E , Hector A, Marcos V, Jung A, Greene C, McElvaney G, Mall M, Döring G. Innate immunity in cystic fibrosis lung disease. J Cyst Fibros. 2012 Aug 20. PMID: 22917571 (review)", + "Gavina M, Luciani A, Villella VR, Esposito S, Ferrari E, Bressani I, Casale A, Bruscia EM , Maiuri L and Raia V. Nebulized Hyaluronan Ameliorates Lung Inflammation in Cystic Fibrosis Mice. Pediatric Pulmonology. 2012 Jul 23. doi: 10.1002/ppul.22637.", + "Bruscia EM , Sangiuolo F, Sinibaldi P, Goncz KK, Novelli G, Gruenert DC. Isolation of CF cell lines corrected at DeltaF508-CFTR locus by SFHR-mediated targeting. Gene Ther. 2002 Jun;9(11):683-5.", + "Sangiuolo F, Bruscia EM , Capon F, Servidei S, Dallapiccola B, Novelli G. Fine mapping of a distinctive autosomal dominant vacuolar neuromyopathy using 11 novel microsatellite markers from chromosome band 19p13.3. Eur J Hum Genet. 2000 Oct;8(10):809-12.", + "Colosimo A, Serafino A, Sangiuolo F, Di Sario S, Bruscia EM , Amicucci P, Novelli G, Dallapiccola B, Mossa G. Gene transfection efficiency of tracheal epithelial cells by DC-chol-DOPE/DNA complexes. Biochim Biophys Acta. 1999 Jul 15;1419(2):186-94.", + "Semprini S, Capon F, Bovolenta S, Bruscia EM , Pizzuti A, Fabrizi G, Schietroma C, Zambruno G, Dallapiccola B, Novelli G. Genomic structure, promoter characterization and mutational analysis of the S100A7 gene: exclusion of a candidate for familial psoriasis susceptibility. Hum Genet. 1999 Feb;104:130-4.", + "Maps & Directions", + "1 Event you could attend in November 2025 Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Bunick Lab", + "lab_url": "https://medicine.yale.edu/lab/bunick/", + "research_bio": "INFORMATION FOR Copy Link Copy Link Associate Professor of Dermatology Associate Research Scientist Research Associate 2, MS - Bunick Lab Research Scientist in Dermatology; Affiliated Faculty, Yale Institute for Global Health Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/bunick/publications", + "publications": [ + "Yale School of Medicine /", + "Dermatology /", + "Research", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Publications", + "", + "", + "", + "", + "", + "", + "Safety of upadacitinib in atopic dermatitis in randomized clinical trials across 6 years. Bunick CG, Irvine AD, Silverberg JI, Guttman-Yassky E, Shahriari M, Gao X, Weidinger S, Katoh N, Vigna N, Dilley DM, D'Andrea E, Teixeira HD, Platt AM, Levy GF. J Eur Acad Dermatol Venereol. 2025 Nov 15; 2025 Nov 15. PMID: 41239921.", + "Pustular psoriasis following treatment with biologics among patients with plaque psoriasis: a nationwide cohort study. Loft N, Zachariae C, Kaur-Knudsen D, Bunick CG, Gilliet M, Skov L. Br J Dermatol. 2025 Nov 8; 2025 Nov 8. PMID: 41206720.", + "Author Correction: Enhancing randomized clinical trials with digital twins. Akbarialiabad H, Pasdar A, Murrell DF, Mostafavi M, Shakil F, Safaee E, Leachman SA, Haghighi A, Tarbox M, Bunick CG, Grada A. NPJ Syst Biol Appl. 2025 Nov 6; 2025 Nov 6. PMID: 41198687.", + "Correction to: Summary of Research: Efficacy and Safety of Delgocitinib Cream in Adults with Moderate to Severe Chronic Hand Eczema (DELTA 1 and DELTA 2): Results from Multicentre, Randomised, Controlled, Double‑Blind, Phase 3 Trials. Bissonnette R, Albreiki F, Ehst BD, Al Hammadi A, Schliemann S, Yang B, Zhang J, Bunick CG. Am J Clin Dermatol. 2025 Nov 1; 2025 Nov 1. PMID: 41175337.", + "Response to Veenstra et al's \"Benzoyl peroxide acne treatment shows no significant association with benzene-related cancers: A multicenter retrospective analysis\" on statistical design. Bunick CG, Yang K, Jafarian F, Barbieri JS. J Am Acad Dermatol. 2025 Oct 13; 2025 Oct 13. PMID: 41093062.", + "Risk of Nonmelanoma Skin Cancer in Patients with Moderate-to-Severe Atopic Dermatitis: A United States Population-Based Study. Lebwohl M, Yue E, Krueger WS, Berman B, Bunick CG, Schlesinger T, Grada A. Dermatol Ther (Heidelb). 2025 Oct 13; 2025 Oct 13. PMID: 41082088.", + "Enhancing randomized clinical trials with digital twins. Akbarialiabad H, Pasdar A, Murrell DF, Mostafavi M, Shakil F, Safaee E, Leachman SA, Haghighi A, Tarbox M, Bunick CG, Grada A. NPJ Syst Biol Appl. 2025 Oct 3; 2025 Oct 3. PMID: 41044102.", + "INDIVIDUAL ARTICLE: The Utility of Delgocitinib in Chronic Hand Eczema. Issa NT, Yu J, Bunick CG, Kircik L. J Drugs Dermatol. 2025 Oct 1. PMID: 41037535.", + "When topicals fall short, oral Janus kinase inhibitors offer a needed solution in chronic hand eczema. Bunick CG. JAAD Int. 2025 Oct; 2025 Jul 17. PMID: 40831621.", + "Summary of Research: Efficacy and Safety of Delgocitinib Cream in Adults with Moderate to Severe Chronic Hand Eczema (DELTA 1 and DELTA 2): Results from Multicentre, Randomised, Controlled, Double-Blind, Phase 3 Trials. Bissonnette R, Albreiki F, Ehst BD, Al Hammadi A, Schliemann S, Yang B, Zhang J, Bunick CG. Am J Clin Dermatol. 2025 Sep 26; 2025 Sep 26. PMID: 41006920.", + "Systemic Corticosteroid Use in Atopic Dermatitis: A Position Paper to Inform Safer Clinical Practice and Policy. Burshtein J, Bunick CG, Vleugels RA, Armstrong AW, Golant AK, Schlesinger T, Strober BE, Song EJ, Gold LS, Lebwohl M. J Invest Dermatol. 2025 Sep 6; 2025 Sep 6. PMID: 40914897.", + "Space Oncology: A Comprehensive Scoping Review. Niknam N, Akbarialiabad H, Farjoud Kouhanjani M, Kolaparambil Varghese LJ, Berrington de González A, Melin MM, Shafie'ei M, Mousavi SM, Hosseini SA, Taha SR, Russomano T, Murrell DF, Grada A, Leachman SA, Akbari Z, Derisi AJ, Jurga M, Kumar A, Das S, D'Urbano J, Hakim G, Sadeghian N, Paydar S, Tarbox M, West C, Ghorashi SM, Hosseini SH, Squire T, Bunick CG, Christiansen R. Wilderness Environ Med. 2025 Sep; 2025 Jul 13. PMID: 40653854.", + "A Disproportionality Analysis on Benzoyl Peroxide and Its Risk of Malignancy Using the FDA Adverse Event Reporting System. Yang K, Czyz S, Zuberi R, Kreutz J, Bunick CG, Jafarian F. J Invest Dermatol. 2025 Sep; 2025 Mar 7. PMID: 40058570.", + "Structural Basis for Differential Jak2 and Jak3 Kinase Selectivity of Ruxolitinib and Delgocitinib. Wang J, Bunick CG. J Invest Dermatol. 2025 Aug 16; 2025 Aug 16. PMID: 40825469.", + "Biologic Therapies Targeting Type 2 Signaling in Atopic Dermatitis: A Comparative Review of Structural and Thermodynamic Differences in Mechanism of Action. Bunick CG. J Invest Dermatol. 2025 Aug 6; 2025 Aug 6. PMID: 40767793.", + "Impact of Achieving Optimal Treatment Targets and Minimal Disease Activity on Health-Related Quality of Life and Satisfaction in Patients with Atopic Dermatitis. Silverberg JI, Gooderham M, Wollenberg A, Pink AE, Ruiz Dasilva D, Kwatra SG, Binamer Y, Katoh N, Aoki V, Moreira A, Grada A, Li C, Calimlim B, Lee WJ, Bunick CG. Dermatol Ther (Heidelb). 2025 Aug; 2025 Jun 26. PMID: 40569545.", + "Benzoyl Peroxide-Containing Products and Benzene: Where Are We Now After Recalls, and How Should We Move Forward? Barbieri JS, Bunick CG. JAMA Dermatol. 2025 Aug 1. PMID: 40531498.", + "Revisiting RORγt Inhibition in Plaque Psoriasis: Lessons Learned from BI 730357. Akbarialiabad H, Bunick CG. J Invest Dermatol. 2025 Aug; 2025 May 27. PMID: 40423599.", + "Response to Barbieri et al. Kucera K, Bunick CG, Light DY. J Invest Dermatol. 2025 Aug; 2025 Feb 19. PMID: 39983978.", + "The skin microbiome in dermatologic disease. MacGibeny MA, Adjei S, Pyle H, Bunick CG, Ghannoum M, Grada A, Harris-Tryon T, Tyring SK, Kong HH. J Am Acad Dermatol. 2025 Aug; 2024 Aug 20. PMID: 39173885.", + "The human skin microbiome in health. MacGibeny MA, Adjei S, Pyle H, Bunick CG, Ghannoum M, Grada A, Harris-Tryon T, Tyring SK, Kong HH. J Am Acad Dermatol. 2025 Aug; 2024 Aug 19. PMID: 39168311.", + "A Justification to Using the FDA Adverse Event Reporting System for Hypothesis Generation Regarding Benzoyl Peroxide. Yang K, Bunick CG, Jafarian F. J Invest Dermatol. 2025 Jul 7; 2025 Jul 7. PMID: 40633753.", + "Structural Insights: What Makes Some PDE4 Inhibitors More Effective in Inflammatory Dermatoses. Issa NT, Wang J, Hanly A, Ho M, Obagi S, Damiani G, Del Rosso JQ, Kang Y, Bunick CG. J Clin Aesthet Dermatol. 2025 Jul 1. PMID: 40778010.", + "Treating Chronic Hand Eczema with Upadacitinib: Insights from Clinical Trials and Real-World Experience. Alani O, Shqair L, Liszewski WJ, Yu H, Draw I, Wahood S, Galimberti F, Sweney B, Obagi S, Mastro A, Dasilva D, Bunick CG. J Drugs Dermatol. 2025 Jul 1. PMID: 40627583.", + "Surface keratin 1, a tumor-selective peptide target in human triple-negative breast cancer. Yao SJ, Amirrad F, Ziaei E, Saghaeidehkordi A, Roosan MR, Shamloo K, Sharma A, Sumbria RK, Nauli SM, Bunick CG, Kaur K. Sci Rep. 2025 Jul 1; 2025 Jul 1. PMID: 40595898.", + "Correction to: Real-World Evidence of Tralokinumab Effectiveness and Safety: A Systematic Review and Meta-analysis. Rønnstad ATM, Bunick CG, Chovatiya R, Kamata M, Nielsen ML, Isufi D, Thomsen SF, Vestergaard C, Wollenberg A, Egeberg A, Thyssen JP, Loft N. Am J Clin Dermatol. 2025 Jul. PMID: 40272773.", + "The Epidemiology of Atopic Dermatitis among Adults and Adolescents with Alopecia Areata in the United States. Bunick CG, Armstrong AW, Grada A, Soliman AM, Li C, Bristow CC, Khan IA, Lipiszko D, Silverberg JI, Issa NT, Mostaghimi A. J Invest Dermatol. 2025 Jun 26; 2025 Jun 26. PMID: 40581103.", + "PDE4 Inhibitors: Bridging Molecular Insights With Clinical Impact. Issa NT, Obagi S, Damiani G, Wang J, Bunick CG. J Drugs Dermatol. 2025 Jun 1. PMID: 40465498.", + "Chemical, Biochemical, and Structural Similarities and Differences of Dermatological cAMP Phosphodiesterase-IV Inhibitors. Wang J, Ho M, Bunick CG. J Invest Dermatol. 2025 Jun; 2024 Nov 27. PMID: 39608668.", + "Pharmacological Characterization of Zasocitinib (TAK-279): An Oral, Highly Selective, and Potent Allosteric TYK2 Inhibitor. Mehrotra S, Sano Y, Halkowycz P, Wilson E, Durairaj C, Kong KF, Xia G, Dunbar F, Spector T, Heap GA, Bunick CG, McInnes IB. J Invest Dermatol. 2025 May 27; 2025 May 27. PMID: 40441292.", + "Fluoroquinolones for Dermatologists: A Practical Guide to Clinical Use and Risk Management. Wahood S, Alani O, Draw I, Shqair L, Wang D, Bunick CG, Damiani G, Ho JD, Obagi S, Akbarialiabad H, Galimberti F, Ghannoum M, Grada A. Pharmaceuticals (Basel). 2025 May 26; 2025 May 26. PMID: 40573197.", + "A Triple-Action Inhibitory Mechanism of Allosteric TYK2-Specific Inhibitors. Wang J, Lomakin IB, Batista VS, Bunick CG. J Invest Dermatol. 2025 May 14; 2025 May 14. PMID: 40378946.", + "Tralokinumab as a Therapeutic Alternative for Dupilumab-associated Arthralgia in Atopic Dermatitis: A Multi-center Case Series. Greenberg ABW, Shahriari M, Cameron MC, Payette M, Dasilva DR, Damiani G, Herman EI, Eminger LA, Issa NT, Rodriguez A, Del Rosso JQ, Kang Y, Cohen JM, Bunick CG. J Clin Aesthet Dermatol. 2025 May 1. PMID: 40538523.", + "Is Upadacitinib Cardioprotective in Chronic Inflammatory Diseases? A Review of Major Adverse Cardiovascular Events and Venous Thromboembolism in Atopic Dermatitis. Alani O, Wang D, Wahood S, Obagi S, Dasilva D, Zirwas MJ, Galimberti F, Bunick CG. J Drugs Dermatol. 2025 May 1. PMID: 40327575.", + "Leveraging space innovations for cancer breakthroughs on Earth. Akbarialiabad H, Jamshidi P, Aminzade Z, Azizi N, Taha SR, Sadeghian N, Varghese LJK, Kouhanjani MF, Niknam N, Babocs D, El-Assaad F, Russomano T, Murrell DF, Paydar S, Bunick CG, Christiansen R, Mark Melin M. Trends Cancer. 2025 May; 2025 Mar 12. PMID: 40082142.", + "Real-World Evidence of Tralokinumab Effectiveness and Safety: A Systematic Review and Meta-analysis. Rønnstad ATM, Bunick CG, Chovatiya R, Kamata M, Nielsen ML, Isufi D, Thomsen SF, Vestergaard C, Wollenberg A, Egeberg A, Thyssen JP, Loft N. Am J Clin Dermatol. 2025 May; 2025 Mar 5. PMID: 40045152.", + "Evaluation of Benzene Presence and Formation in Benzoyl Peroxide Drug Products. Kucera K, Zenzola N, Hudspeth A, Dubnicka M, Hinz W, Bunick CG, Girardi M, Dabestani A, Light DY. J Invest Dermatol. 2025 May; 2024 Oct 7. PMID: 39384016.", + "Autosomal dominant SLURP1 variants cause palmoplantar keratoderma and progressive symmetric erythrokeratoderma. Jiang X, Mortlock RD, Lomakin IB, Zhou J, Hu R, Cossio ML, Bunick CG, Choate KA. Br J Dermatol. 2025 Apr 28. PMID: 39913669.", + "Psoriasis: Perspectives from Irwin M. Braverman, MD. Cohen JM, Bunick CG. Clin Dermatol. 2025 Mar-Apr; 2024 Dec 21. PMID: 39716549.", + "INDIVIDUAL ARTICLE: Appraisal of Ruxolitinib 1.5% Cream as a First-Line Topical Therapeutic Agent for Adolescents and Adults With Mild-to-Moderate Atopic Dermatitis. Issa NT, Kwong P, Bunick CG, Kircik L. J Drugs Dermatol. 2025 Feb 1. PMID: 39913233.", + "INDIVIDUAL ARTICLE: Ruxolitinib 1.5% Cream and the \"Boxed Warning Paradox\": Reappraisal of Safety Through the Lens of Pharmacokinetics. Issa NT, Kwong P, Bunick CG, Kircik L. J Drugs Dermatol. 2025 Feb 1. PMID: 39913232.", + "Practical Guide for Implementing Cryogenic Electron Microscopy Structure Determination in Dermatology Research. Lomakin IB, Devarkar SC, Freniere C, Bunick CG. J Invest Dermatol. 2025 Jan; 2024 Nov 26. PMID: 39601740.", + "Efficacy and safety of upadacitinib versus dupilumab in adults and adolescents with moderate-to-severe atopic dermatitis: week 16 results of an open-label randomized efficacy assessor-blinded head-to-head phase IIIb/IV study (Level Up). Silverberg JI, Bunick CG, Hong HC, Mendes-Bastos P, Stein Gold L, Costanzo A, Ibrahim N, Sancho C, Wu X, Han Y, Levy G, Altman K, Calimlim B, Eyerich K. Br J Dermatol. 2024 Dec 23. PMID: 39438067.", + "Real-world evidence on the benefits of optimal itch relief and skin clearance in atopic dermatitis management: a study from the TARGET-DERM AD registry. Silverberg JI, Calimlim BM, Grada A, Bunick CG, Gooderham MJ, Shi VY, Obi C, Knapp KD, Munoz B, Crawford JM, Paller AS. J Dermatolog Treat. 2024 Dec; 2024 Dec 11. PMID: 39662888.", + "Mechanistic Basis for the Translation Inhibition of Cutibacterium acnes by Clindamycin. Lomakin IB, Devarkar SC, Grada A, Bunick CG. J Invest Dermatol. 2024 Nov; 2024 Aug 8. PMID: 39122144.", + "Crystal Structure of Bimekizumab Fab Fragment in Complex with IL-17F Provides Molecular Basis for Dual IL-17A and IL-17F Inhibition. Adams R, Bunick CG, Lawson ADG, Gomez B, Shaw S. J Invest Dermatol. 2024 Nov; 2024 Apr 16. PMID: 38631666.", + "Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel for Male and Female Acne: Phase 3 Analysis. Lain ET, Bhatia N, Kircik L, Gold LS, Harper JC, Bunick CG, Guenin E, Baldwin H, Feldman SR, Rosso JQD. J Drugs Dermatol. 2024 Oct 1. PMID: 39361705.", + "Structural Insights: What Makes Some IL-23 Biologics More Effective in Psoriasis. Daniele SG, Galimberti F, Bunick CG. J Drugs Dermatol. 2024 Oct 1. PMID: 39361690.", + "In response to Reynolds et al's \"guidelines of care for the management of acne vulgaris\". Issa NT, Bunick CG. J Am Acad Dermatol. 2024 Oct; 2024 Jun 21. PMID: 38909659.", + "Clindamycin: A Comprehensive Status Report with Emphasis on Use in Dermatology. Del Rosso JQ, Armillei MK, Lomakin IB, Grada A, Bunick CG. J Clin Aesthet Dermatol. 2024 Aug. PMID: 39148960.", + "Rapid Remission of Plaque Psoriasis With Bimekizumab Treatment. Abdin R, Gharib R, Bunick CG, Issa NT. J Drugs Dermatol. 2024 Aug 1. PMID: 39093648.", + "Topical Clindamycin in the Management of Acne Vulgaris: Current Perspectives and Recent Therapeutic Advances. Del Rosso JQ, Bunick CG, Kircik L, Bhatia N. J Drugs Dermatol. 2024 Jun 1. PMID: 38834223.", + "Unveiling the secrets of vimentin filament architecture relevant to human disease. Lomakin IB, Ho M, Bunick CG. Nat Struct Mol Biol. 2024 Jun. PMID: 38684931.", + "Triple Combination Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% for Acne: Efficacy and Safety from a Pooled Phase 3 Analysis. Kircik LH, Stein Gold L, Gold M, Weiss JS, Harper JC, Del Rosso JQ, Bunick CG, Bhatia N, Tanghetti EA, Eichenfield LF, Baldwin H, Draelos ZD, Callender VD, Han G, Gooderham MJ, Sadick N, Lupo MP, Lain ET, Werschler WP. Dermatol Ther (Heidelb). 2024 May; 2024 May 9. PMID: 38724841.", + "Early and Sustained Improvements in Symptoms and Quality of Life with Upadacitinib in Adults and Adolescents with Moderate-to-Severe Atopic Dermatitis: 52-Week Results from Two Phase III Randomized Clinical Trials (Measure Up 1 and Measure Up 2). Silverberg JI, Gooderham MJ, Paller AS, Deleuran M, Bunick CG, Gold LFS, Hijnen D, Calimlim BM, Lee WJ, Teixeira HD, Hu X, Zhang S, Yang Y, Grada A, Platt AM, Thaçi D. Am J Clin Dermatol. 2024 May; 2024 Mar 25. PMID: 38528257.", + "Altered skin microbiome, inflammation, and JAK/STAT signaling in Southeast Asian ichthyosis patients. Ho M, Nguyen HN, Van Hoang M, Bui TTT, Vu BQ, Dinh THT, Vo HTM, Blaydon DC, Eldirany SA, Bunick CG, Bui CB. Hum Genomics. 2024 Apr 16; 2024 Apr 16. PMID: 38627868.", + "Scientific Rationale and Clinical Basis for Clindamycin Use in the Treatment of Dermatologic Disease. Armillei MK, Lomakin IB, Del Rosso JQ, Grada A, Bunick CG. Antibiotics (Basel). 2024 Mar 17; 2024 Mar 17. PMID: 38534705.", + "Rethinking Hidradenitis Suppurativa Management: Insights into Bacterial Interactions and Treatment Evolution. Huynh FD, Damiani G, Bunick CG. Antibiotics (Basel). 2024 Mar 17; 2024 Mar 17. PMID: 38534703.", + "Benzoyl Peroxide Drug Products Form Benzene. Kucera K, Zenzola N, Hudspeth A, Dubnicka M, Hinz W, Bunick CG, Dabestani A, Light DY. Environ Health Perspect. 2024 Mar; 2024 Mar 14. PMID: 38483533.", + "Structural Basis for p19 Targeting by Anti-IL-23 Biologics: Correlations with Short- and Long-Term Efficacy in Psoriasis. Daniele SG, Eldirany SA, Damiani G, Ho M, Bunick CG. JID Innov. 2024 Mar; 2024 Jan 20. PMID: 38445231.", + "Triple-action inhibitory mechanism of allosteric TYK2-specific inhibitors. Wang J, Batista VS, Bunick CG. bioRxiv. 2023 Oct 9; 2023 Oct 9. PMID: 37873392.", + "Ensuring Dermatologists Practice Enhanced Antibiotic Stewardship With Sarecycline Mnemonic. Borash J, Bunick CG, Graber E. J Drugs Dermatol. 2023 Oct 1. PMID: 37801533.", + "Circadian Oscillations of Minimal Erythema Dose (MED) are Also Influenced by Diet in Patients with Psoriasis: A Chronomedical Study. Damiani G, Pacifico A, Scoditti E, di Gregorio S, Del Fabbro M, Cozzolino C, Buja A, Mercuri SR, Bianchi VG, Grada A, Garbarino S, Bunick CG. Dermatol Ther (Heidelb). 2023 Oct; 2023 Aug 12. PMID: 37573289.", + "Acne accounts for an almost 2.5-fold higher proportion of dermatology visits among adult females compared to adult males in the United States: A study of the national ambulatory medical care survey from 2002-2016. Chang J, Nock MR, Cohen JM, Bunick CG. PLoS One. 2023; 2023 Sep 21. PMID: 37733776.", + "Antimicrobial Wound Dressings: A Concise Review for Clinicians. Yousefian F, Hesari R, Jensen T, Obagi S, Rgeai A, Damiani G, Bunick CG, Grada A. Antibiotics (Basel). 2023 Sep 11; 2023 Sep 11. PMID: 37760730.", + "Congenital Ichthyosis: A Practical Clinical Guide on Current Treatments and Future Perspectives. Lilly E, Bunick CG. Clin Cosmet Investig Dermatol. 2023; 2023 Sep 11. PMID: 37719935.", + "Demystifying Hand Eczema. Grada A, Bunick CG. J Invest Dermatol. 2023 Aug; 2023 Apr 27. PMID: 37115112.", + "Characteristics and outcomes for participants with congenital ichthyosis who responded to treatment with the topical isotretinoin formulation TMB-001: results from the Phase IIb CONTROL study. Bunick CG, Teng JMC, Guenthner S, Marathe K, Kempers S, Eads K, Castelo-Soccio L, Mendelsohn AM, Raiz J, Murrell DF. Clin Exp Dermatol. 2023 Jul 7. PMID: 36928932.", + "Phase IIb randomized CONTROL study demonstrates a novel topical isotretinoin formulation, TMB-001, is safe and effective in participants with either recessive X-linked or autosomal recessive lamellar congenital ichthyosis. Murrell DF, Teng JMC, Guenthner S, Marathe K, Kempers S, Eads K, Castelo-Soccio L, Mendelsohn AM, Raiz J, Bunick CG. Clin Exp Dermatol. 2023 Jun 5. PMID: 36794376.", + "Topical Isotretinoin (TMB-001) Treatment for 12 Weeks Did Not Result in Clinically Relevant Laboratory Abnormalities in Participants with Congenital Ichthyosis in the Phase 2b CONTROL Study. Marathe K, Teng JMC, Guenthner S, Bunick CG, Kempers S, Eads K, Castelo-Soccio L, Mendelsohn AM, Raiz J, Murrell DF. Dermatol Ther (Heidelb). 2023 Jun; 2023 May 11. PMID: 37170057.", + "Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism. Lomakin IB, Devarkar SC, Patel S, Grada A, Bunick CG. Nucleic Acids Res. 2023 Apr 11. PMID: 36864821.", + "Inguinal patch in mpox (monkeypox) virus infection and eccrine syringometaplasia: report of two cases with in situ hybridization and electron microscopy findings. Roy SF, Sarhan J, Liu X, Murphy MJ, Bunick CG, Choate KA, Damsky WB, McNiff JM. Br J Dermatol. 2023 Mar 30. PMID: 36763786.", + "Structural basis for differential p19 targeting by IL-23 biologics. Daniele SG, Eldirany SA, Ho M, Bunick CG. bioRxiv. 2023 Mar 9; 2023 Mar 9. PMID: 36945513.", + "Trends in Oral Antibiotic Use for Acne Treatment: A Retrospective, Population-Based Study in the United States, 2014 to 2016. Grada A, Armstrong A, Bunick C, Salem R, Feldman S. J Drugs Dermatol. 2023 Mar 1. PMID: 36877883.", + "Truncal Acne and Scarring: A Comprehensive Review of Current Medical and Cosmetic Approaches to Treatment and Patient Management. Daniele SG, Kim SR, Grada A, Moore AY, Suozzi KC, Bunick CG. Am J Clin Dermatol. 2023 Mar; 2022 Dec 20. PMID: 36539678.", + "Reduced blood-brain barrier penetration of acne vulgaris antibiotic sarecycline compared to minocycline corresponds with lower lipophilicity. Grada A, Del Rosso JQ, Moore AY, Stein Gold L, Harper J, Damiani G, Shaw K, Obagi S, Salem RJ, Tanaka SK, Bunick CG. Front Med (Lausanne). 2022; 2022 Dec 8. PMID: 36569144.", + "JAK Inhibitor Safety Compared to Traditional Systemic Immunosuppressive Therapies. Daniele S, Bunick C. J Drugs Dermatol. 2022 Dec 1. PMID: 36468956.", + "The CONTROL study: A randomized, double-blind vehicle-controlled phase 2b study of novel topical isotretinoin formulation demonstrates improvement in recessive X-linked and autosomal recessive lamellar congenital ichthyosis. Teng JMC, Bunick CG, Guenthner S, Murrell DF, Marathe K, Kempers S, Eads K, Mendelsohn AM, Raiz J, Tavakkol A, Castelo-Soccio L. J Am Acad Dermatol. 2022 Dec; 2022 Jul 21. PMID: 35872261.", + "Safety, tolerability, and efficacy of a novel topical isotretinoin formulation for the treatment of X-linked or lamellar congenital ichthyosis: Results from a phase 2a proof-of-concept study. Paller AS, Browning J, Parish LC, Bunick CG, Rome Z, Bhatia N. J Am Acad Dermatol. 2022 Nov; 2022 Mar 7. PMID: 35271936.", + "Stenotrophomonas maltophilia, a Pathogen of Increasing Relevance to Dermatologists: A Case Report and Review of the Literature. Belzer A, Weiss E, Etaee F, Bunick CG, Damsky W, Nelson CA. Antibiotics (Basel). 2022 Oct 12; 2022 Oct 12. PMID: 36290055.", + "Antibiotic Resistance Risk with Oral Tetracycline Treatment of Acne Vulgaris. Swallow MA, Fan R, Cohen JM, Bunick CG. Antibiotics (Basel). 2022 Jul 30; 2022 Jul 30. PMID: 36009899.", + "Sarecycline Demonstrates Clinical Effectiveness against Staphylococcal Infections and Inflammatory Dermatoses: Evidence for Improving Antibiotic Stewardship in Dermatology. Grada A, Ghannoum MA, Bunick CG. Antibiotics (Basel). 2022 May 27; 2022 May 27. PMID: 35740129.", + "Sarecycline treatment for acne vulgaris: Rationale for weight-based dosing and limited impact of food intake on clinical efficacy. Grada A, Del Rosso JQ, Graber E, Bunick CG, Stein Gold L, Moore AY, Baldwin H, Obagi Z, Damiani G, Carrothers T, McNamee B, Hanze E. Dermatol Ther. 2022 Mar; 2021 Dec 30. PMID: 34923732.", + "Sarecycline Demonstrated Reduced Activity Compared to Minocycline against Microbial Species Representing Human Gastrointestinal Microbiota. Ghannoum MA, Long L, Bunick CG, Del Rosso JQ, Gamal A, Tyring SK, McCormick TS, Grada A. Antibiotics (Basel). 2022 Feb 28; 2022 Feb 28. PMID: 35326788.", + "Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders. Ho M, Thompson B, Fisk JN, Nebert DW, Bruford EA, Vasiliou V, Bunick CG. Hum Genomics. 2022 Jan 6; 2022 Jan 6. PMID: 34991727.", + "Keratin 1 as a cell-surface receptor in cancer. Ogunnigbagbe O, Bunick CG, Kaur K. Biochim Biophys Acta Rev Cancer. 2022 Jan; 2021 Dec 7. PMID: 34890750.", + "Genotype‒Structurotype‒Phenotype Correlations in Patients with Pachyonychia Congenita. Wu TT, Eldirany SA, Bunick CG, Teng JMC. J Invest Dermatol. 2021 Dec; 2021 Jun 8. PMID: 34116063.", + "Dermatomyositis associated with an adrenal adenoma. Eldirany SA, Ring N, Laskin W, Bunick CG. JAAD Case Rep. 2021 Jun; 2021 Apr 28. PMID: 34041336.", + "Antibacterial Mechanisms and Efficacy of Sarecycline in Animal Models of Infection and Inflammation. Bunick CG, Keri J, Tanaka SK, Furey N, Damiani G, Johnson JL, Grada A. Antibiotics (Basel). 2021 Apr 15; 2021 Apr 15. PMID: 33920812.", + "Spectrum of Antibiotic Activity and Its Relevance to the Microbiome. Grada A, Bunick CG. JAMA Netw Open. 2021 Apr 1; 2021 Apr 1. PMID: 33914053.", + "Recent insight into intermediate filament structure. Eldirany SA, Lomakin IB, Ho M, Bunick CG. Curr Opin Cell Biol. 2021 Feb; 2020 Nov 12. PMID: 33190098.", + "Patient and physician perspectives on teledermatology at an academic dermatology department amid the COVID-19 pandemic. Asabor EN, Bunick CG, Cohen JM, Perkins SH. J Am Acad Dermatol. 2021 Jan; 2020 Sep 15. PMID: 32946971.", + "The new normal: An approach to optimizing and combining in-person and telemedicine visits to maximize patient care. Cohen JM, Bunick CG, Perkins SH. J Am Acad Dermatol. 2020 Nov; 2020 Jun 25. PMID: 32593636.", + "Structural properties of target binding by profilaggrin A and B domains and other S100 fused-type calcium-binding proteins. Hinbest AJ, Kim SR, Eldirany SA, Lomakin IB, Watson J, Ho M, Bunick CG. J Dermatol Sci. 2020 Oct; 2020 Aug 21. PMID: 32893105.", + "Molecular Modeling of Pathogenic Mutations in the Keratin 1B Domain. Hinbest AJ, Eldirany SA, Ho M, Bunick CG. Int J Mol Sci. 2020 Sep 10; 2020 Sep 10. PMID: 32927888.", + "Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Batool Z, Lomakin IB, Polikanov YS, Bunick CG. Proc Natl Acad Sci U S A. 2020 Aug 25; 2020 Aug 12. PMID: 32817463.", + "Teledermatology in the era of COVID-19: Experience of an academic department of dermatology. Perkins S, Cohen JM, Nelson CA, Bunick CG. J Am Acad Dermatol. 2020 Jul; 2020 Apr 17. PMID: 32305442.", + "CD8(+) mycosis fungoides palmaris et plantaris with peripheral blood involvement. Yumeen S, Mirza FN, Lewis JM, Carlson KR, King B, Cowper S, Bunick CG, McNiff J, Girardi M. JAAD Case Rep. 2020 May; 2020 Apr 30. PMID: 32382639.", + "Structural Basis for How Biologic Medicines Bind their Targets in Psoriasis Therapy. Eldirany SA, Ho M, Bunick CG. Yale J Biol Med. 2020 Mar; 2020 Mar 27. PMID: 32226331.", + "Crystal Structure of Keratin 1/10(C401A) 2B Heterodimer Demonstrates a Proclivity for the C-Terminus of Helix 2B to Form Higher Order Molecular Contacts. Lomakin IB, Hinbest AJ, Ho M, Eldirany SA, Bunick CG. Yale J Biol Med. 2020 Mar; 2020 Mar 27. PMID: 32226330.", + "Sterling Hall of Medicine 333 Cedar Street New Haven, CT 06520-8023 Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "C. Shan Xu Lab", + "lab_url": "https://medicine.yale.edu/lab/shan-xu/", + "research_bio": "INFORMATION FOR Our primary research interest is transformative instrumentation development. At the forefront ofvolume Electron Microscopy(vEM), we aim to develop next generation technologies to enable discoveries from engineering to life science to clinical applications. Copy Link We have demonstrated the first complete pipeline from high-resolution large volume imaging to subsequent analyses to biological/medical discoveries, representing the beginning of a new field of high-resolution large volume electron microscopy to reveal the structure-function relationships in biology. ThisDrosophila“hemi-brain” connectome consisting of ~11x106µm3tissue volume and 13 “hotknife” tabs was imaged with 8-nm voxels using two enhanced FIB-SEM systems in parallel for two years at the Janelia Research Campus of HHMI. (Scheffer et al.,eLife2020). View video details Higher resolution further improves the interpretation of otherwise ambiguous details. We further advanced the enhanced FIB-SEM technology and created the first open-access 3D atlas of whole cells and tissues (OpenOrganelle) at the finest isotropic resolution of 4-nm voxels (Xu et al.,Nature2021). View video details Through our 3D FIB-SEM imaging of large intact liver tissues under different nutritional states, Hotamisligil Lab at Harvard was the first to link liver subcellular architecture to metabolic function, and showed that recovery of structural organization was correlated with restored function (Parlakgül et al.,Nature2022). View video details In collaboration with the Mellman Lab at Genentech Inc., we reported the first comprehensive 3D FIB-SEM datasets of a T cell attacking a cancer cell, providing a unique and complete map of the complex membrane topology at the interface between the T cell and target (Ritter et al.,Science2022, Cover). View video details Combined with cryogenic super-resolution fluorescence microscopy, we established the first whole cell cryo-correlative imaging pipeline that enabled multicolor three-dimensional nanoscale visualization of proteins in the context of global ultrastructure (Hoffman et al.,Science2020, cover). View video details", + "publications_page": "https://medicine.yale.edu/lab/shan-xu/publications", + "publications": [ + "Yale School of Medicine /", + "Research", + "News", + "People", + "Publications", + "Discoveries", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "Discoveries", + "News", + "", + "", + "", + "", + "", + "", + "BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM. Hanna MG, Rodriguez Cruz HO, Fujise K, Wu Y, Xu CS, Pang S, Li Z, Monetti M, De Camilli P. EMBO J. 2025 Nov; 2025 Sep 11. PMID: 40935891.", + "Illuminating Mouse Renal Proximal Tubule Architecture through High-Resolution Volume EM and Machine Learning Analysis. Pandya RD, Lackner EM, Xu CS, Zugates C, Burdyniuk M, Reyna-Neyra A, Pandya VD, Li WP, Pang S, Weisz OA, Caplan MJ. J Am Soc Nephrol. 2025 Oct 6; 2025 Oct 6. PMID: 41051879.", + "Functional evidence for early origin of tactile acuity in the vertebrate somatosensory system. Tan K, Hillgen-Santa LF, Graham M, Li Y, Liu X, Pang S, Gracheva EO, Bagriantsev SN. Curr Biol. 2025 Oct 6; 2025 Sep 12. PMID: 40945511.", + "The first complete 3D reconstruction and morphofunctional mapping of an insect eye. Makarova AA, Chua NJ, Diakova AV, Desyatirkina IA, Gunn P, Pang S, Xu CS, Hess HF, Chklovskii DB, Polilov AA. Elife. 2025 May 1; 2025 May 1. PMID: 40310676.", + "Connectome-driven neural inventory of a complete visual system. Nern A, Loesche F, Takemura SY, Burnett LE, Dreher M, Gruntman E, Hoeller J, Huang GB, Januszewski M, Klapoetke NC, Koskela S, Longden KD, Lu Z, Preibisch S, Qiu W, Rogers EM, Seenivasan P, Zhao A, Bogovic J, Canino BS, Clements J, Cook M, Finley-May S, Flynn MA, Hameed I, Fragniere AMC, Hayworth KJ, Hopkins GP, Hubbard PM, Katz WT, Kovalyak J, Lauchie SA, Leonard M, Lohff A, Maldonado CA, Mooney C, Okeoma N, Olbris DJ, Ordish C, Paterson T, Phillips EM, Pietzsch T, Salinas JR, Rivlin PK, Schlegel P, Scott AL, Scuderi LA, Takemura S, Talebi I, Thomson A, Trautman ET, Umayam L, Walsh C, Walsh JJ, Xu CS, Yakal EA, Yang T, Zhao T, Funke J, George R, Hess HF, Jefferis GSXE, Knecht C, Korff W, Plaza SM, Romani S, Saalfeld S, Scheffer LK, Berg S, Rubin GM, Reiser MB. Nature. 2025 May; 2025 Mar 26. PMID: 40140576.", + "Vimentin filament transport and organization revealed by single-particle tracking and 3D FIB-SEM. Renganathan B, Moore AS, Yeo WH, Petruncio A, Ackerman D, Weigel AV, Team TC, Pasolli HA, Xu CS, Shtengel G, Hess HF, Serpinskaya AS, Zhang HF, Lippincott-Schwartz J, Gelfand VI. J Cell Biol. 2025 Apr 7; 2025 Mar 10. PMID: 40062969.", + "BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM. Hanna MG, Rodriguez Cruz HO, Fujise K, Wu Y, Xu CS, Pang S, Li Z, Monetti M, De Camilli P. bioRxiv. 2025 Apr 3; 2025 Apr 3. PMID: 39386594.", + "Multicilia dynamically transduce Sonic Hedgehog signaling to regulate choroid plexus functions. Mao S, Song R, Jin S, Pang S, Jovanovic A, Zimmerman A, Li P, Wu X, Wendland MF, Lin K, Chen WC, Choksi SP, Chen G, Holtzman MJ, Reiter JF, Wan Y, Xuan Z, Xiang YK, Xu CS, Upadhyayula S, Hess HF, He L. Cell Rep. 2025 Mar 25; 2025 Mar 8. PMID: 40057957.", + "The inner core enables transient touch detection in the Pacinian corpuscle. Ziolkowski LH, Nikolaev YA, Chikamoto A, Oda M, Feketa VV, Monedero-Alonso D, Ardasheva SA, Bae SS, Xu CS, Pang S, Gracheva EO, Bagriantsev SN. Sci Adv. 2025 Feb 28; 2025 Feb 26. PMID: 40009676.", + "Periodic ER-plasma membrane junctions support long-range Ca(2+) signal integration in dendrites. Benedetti L, Fan R, Weigel AV, Moore AS, Houlihan PR, Kittisopikul M, Park G, Petruncio A, Hubbard PM, Pang S, Xu CS, Hess HF, Saalfeld S, Rangaraju V, Clapham DE, De Camilli P, Ryan TA, Lippincott-Schwartz J. Cell. 2025 Jan 23; 2024 Dec 20. PMID: 39708809.", + "Structure, interaction and nervous connectivity of beta cell primary cilia. Müller A, Klena N, Pang S, Garcia LEG, Topcheva O, Aurrecoechea Duran S, Sulaymankhil D, Seliskar M, Mziaut H, Schöniger E, Friedland D, Kipke N, Kretschmar S, Münster C, Weitz J, Distler M, Kurth T, Schmidt D, Hess HF, Xu CS, Pigino G, Solimena M. Nat Commun. 2024 Oct 24; 2024 Oct 24. PMID: 39448638.", + "Structural and functional dissection of the Pacinian corpuscle reveals an active role of the inner core in touch detection. Ziolkowski LH, Nikolaev YA, Chikamoto A, Oda M, Feketa VV, Monedero-Alonso D, Ardasheva SA, Bae SS, Xu CS, Pang S, Gracheva EO, Bagriantsev SN. bioRxiv. 2024 Aug 26; 2024 Aug 26. PMID: 39253434.", + "Transport and Organization of Individual Vimentin Filaments Within Dense Networks Revealed by Single Particle Tracking and 3D FIB-SEM. Renganathan B, Moore A, Yeo WH, Petruncio A, Ackerman D, Wiegel A, Pasolli HA, Xu CS, Shtengel G, Hess HF, Serpinskaya AS, Zhang HF, Lippincott-Schwartz J, Gelfand VI. bioRxiv. 2024 Jun 10; 2024 Jun 10. PMID: 38915582.", + "The physical and cellular mechanism of structural color change in zebrafish. Gur D, Moore AS, Deis R, Pang S, Wu X, Pinkas I, Deo C, Iyer N, Hess HF, Hammer JA, Lippincott-Schwartz J. Proc Natl Acad Sci U S A. 2024 Jun 4; 2024 May 28. PMID: 38805288.", + "COPII with ALG2 and ESCRTs control lysosome-dependent microautophagy of ER exit sites. Liao YC, Pang S, Li WP, Shtengel G, Choi H, Schaefer K, Xu CS, Lippincott-Schwartz J. Dev Cell. 2024 Jun 3; 2024 Apr 8. PMID: 38593803.", + "Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity. Parlakgül G, Pang S, Artico LL, Min N, Cagampan E, Villa R, Goncalves RLS, Lee GY, Xu CS, Hotamışlıgil GS, Arruda AP. Nat Commun. 2024 May 10; 2024 May 10. PMID: 38729945.", + "Motion of VAPB molecules reveals ER-mitochondria contact site subdomains. Obara CJ, Nixon-Abell J, Moore AS, Riccio F, Hoffman DP, Shtengel G, Xu CS, Schaefer K, Pasolli HA, Masson JB, Hess HF, Calderon CP, Blackstone C, Lippincott-Schwartz J. Nature. 2024 Feb; 2024 Jan 24. PMID: 38267577.", + "A complete reconstruction of the early visual system of an adult insect. Chua NJ, Makarova AA, Gunn P, Villani S, Cohen B, Thasin M, Wu J, Shefter D, Pang S, Xu CS, Hess HF, Polilov AA, Chklovskii DB. Curr Biol. 2023 Nov 6; 2023 Sep 28. PMID: 37774707.", + "Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch. Handler A, Zhang Q, Pang S, Nguyen TM, Iskols M, Nolan-Tamariz M, Cattel S, Plumb R, Sanchez B, Ashjian K, Shotland A, Brown B, Kabeer M, Turecek J, DeLisle MM, Rankin G, Xiang W, Pavarino EC, Africawala N, Santiago C, Lee WA, Xu CS, Ginty DD. Neuron. 2023 Oct 18; 2023 Sep 18. PMID: 37725982.", + "3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle. Nikolaev YA, Ziolkowski LH, Pang S, Li WP, Feketa VV, Xu CS, Gracheva EO, Bagriantsev SN. Sci Adv. 2023 Sep 15; 2023 Sep 13. PMID: 37703368.", + "Multiscale head anatomy of Megaphragma (Hymenoptera: Trichogrammatidae). Desyatirkina IA, Makarova AA, Pang S, Xu CS, Hess H, Polilov AA. Arthropod Struct Dev. 2023 Sep; 2023 Sep 2. PMID: 37666087.", + "Comparative connectomics and escape behavior in larvae of closely related Drosophila species. Zhu J, Boivin JC, Pang S, Xu CS, Lu Z, Saalfeld S, Hess HF, Ohyama T. Curr Biol. 2023 Jun 19; 2023 Jun 6. PMID: 37285846.", + "Methods of enhanced FIB-SEM sample preparation and image acquisition. Pang S, Xu CS. Methods Cell Biol. 2023; 2023 Apr 6. PMID: 37451770.", + "En bloc preparation of Drosophila brains enables high-throughput FIB-SEM connectomics. Lu Z, Xu CS, Hayworth KJ, Pang S, Shinomiya K, Plaza SM, Scheffer LK, Rubin GM, Hess HF, Rivlin PK, Meinertzhagen IA. Front Neural Circuits. 2022; 2022 Dec 16. PMID: 36589862.", + "The 3D ultrastructure of the chordotonal organs in the antenna of a microwasp remains complex although simplified. Diakova AV, Makarova AA, Pang S, Xu CS, Hess H, Polilov AA. Sci Rep. 2022 Nov 23; 2022 Nov 23. PMID: 36424494.", + "A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility. Sheu SH, Upadhyayula S, Dupuy V, Pang S, Deng F, Wan J, Walpita D, Pasolli HA, Houser J, Sanchez-Martinez S, Brauchi SE, Banala S, Freeman M, Xu CS, Kirchhausen T, Hess HF, Lavis L, Li Y, Chaumont-Dubel S, Clapham DE. Cell. 2022 Sep 1. PMID: 36055200.", + "Transverse endoplasmic reticulum expansion in hereditary spastic paraplegia corticospinal axons. Zhu PP, Hung HF, Batchenkova N, Nixon-Abell J, Henderson J, Zheng P, Renvoisé B, Pang S, Xu CS, Saalfeld S, Funke J, Xie Y, Svara F, Hess HF, Blackstone C. Hum Mol Genet. 2022 Aug 23. PMID: 35348668.", + "ESCRT-mediated membrane repair protects tumor-derived cells against T cell attack. Ritter AT, Shtengel G, Xu CS, Weigel A, Hoffman DP, Freeman M, Iyer N, Alivodej N, Ackerman D, Voskoboinik I, Trapani J, Hess HF, Mellman I. Science. 2022 Apr 22; 2022 Apr 21. PMID: 35446649.", + "Regulation of liver subcellular architecture controls metabolic homeostasis. Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamışlıgil GS. Nature. 2022 Mar; 2022 Mar 9. PMID: 35264794.", + "Publisher Correction: An open-access volume electron microscopy atlas of whole cells and tissues. Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV Jr, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF. Nature. 2021 Nov. PMID: 34732896.", + "An open-access volume electron microscopy atlas of whole cells and tissues. Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV Jr, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF. Nature. 2021 Nov; 2021 Oct 6. PMID: 34616045.", + "Whole-cell organelle segmentation in volume electron microscopy. Heinrich L, Bennett D, Ackerman D, Park W, Bogovic J, Eckstein N, Petruncio A, Clements J, Pang S, Xu CS, Funke J, Korff W, Hess HF, Lippincott-Schwartz J, Saalfeld S, Weigel AV. Nature. 2021 Nov; 2021 Oct 6. PMID: 34616042.", + "ER-to-Golgi protein delivery through an interwoven, tubular network extending from ER. Weigel AV, Chang CL, Shtengel G, Xu CS, Hoffman DP, Freeman M, Iyer N, Aaron J, Khuon S, Bogovic J, Qiu W, Hess HF, Lippincott-Schwartz J. Cell. 2021 Apr 29; 2021 Apr 13. PMID: 33852913.", + "Protocol for preparation of heterogeneous biological samples for 3D electron microscopy: a case study for insects. Polilov AA, Makarova AA, Pang S, Shan Xu C, Hess H. Sci Rep. 2021 Feb 25; 2021 Feb 25. PMID: 33633143.", + "3D FIB-SEM reconstruction of microtubule-organelle interaction in whole primary mouse β cells. Müller A, Schmidt D, Xu CS, Pang S, D'Costa JV, Kretschmar S, Münster C, Kurth T, Jug F, Weigert M, Hess HF, Solimena M. J Cell Biol. 2021 Feb 1. PMID: 33326005.", + "Chromatin arranges in chains of mesoscale domains with nanoscale functional topography independent of cohesin. Miron E, Oldenkamp R, Brown JM, Pinto DMS, Xu CS, Faria AR, Shaban HA, Rhodes JDP, Innocent C, de Ornellas S, Hess HF, Buckle V, Schermelleh L. Sci Adv. 2020 Sep; 2020 Sep 23. PMID: 32967822.", + "A connectome and analysis of the adult Drosophila central brain. Scheffer LK, Xu CS, Januszewski M, Lu Z, Takemura SY, Hayworth KJ, Huang GB, Shinomiya K, Maitlin-Shepard J, Berg S, Clements J, Hubbard PM, Katz WT, Umayam L, Zhao T, Ackerman D, Blakely T, Bogovic J, Dolafi T, Kainmueller D, Kawase T, Khairy KA, Leavitt L, Li PH, Lindsey L, Neubarth N, Olbris DJ, Otsuna H, Trautman ET, Ito M, Bates AS, Goldammer J, Wolff T, Svirskas R, Schlegel P, Neace E, Knecht CJ, Alvarado CX, Bailey DA, Ballinger S, Borycz JA, Canino BS, Cheatham N, Cook M, Dreher M, Duclos O, Eubanks B, Fairbanks K, Finley S, Forknall N, Francis A, Hopkins GP, Joyce EM, Kim S, Kirk NA, Kovalyak J, Lauchie SA, Lohff A, Maldonado C, Manley EA, McLin S, Mooney C, Ndama M, Ogundeyi O, Okeoma N, Ordish C, Padilla N, Patrick CM, Paterson T, Phillips EE, Phillips EM, Rampally N, Ribeiro C, Robertson MK, Rymer JT, Ryan SM, Sammons M, Scott AK, Scott AL, Shinomiya A, Smith C, Smith K, Smith NL, Sobeski MA, Suleiman A, Swift J, Takemura S, Talebi I, Tarnogorska D, Tenshaw E, Tokhi T, Walsh JJ, Yang T, Horne JA, Li F, Parekh R, Rivlin PK, Jayaraman V, Costa M, Jefferis GS, Ito K, Saalfeld S, George R, Meinertzhagen IA, Rubin GM, Hess HF, Jain V, Plaza SM. Elife. 2020 Sep 7; 2020 Sep 7. PMID: 32880371.", + "Chloroplast Sec14-like 1 (CPSFL1) is essential for normal chloroplast development and affects carotenoid accumulation in Chlamydomonas. García-Cerdán JG, Schmid EM, Takeuchi T, McRae I, McDonald KL, Yordduangjun N, Hassan AM, Grob P, Xu CS, Hess HF, Fletcher DA, Nogales E, Niyogi KK. Proc Natl Acad Sci U S A. 2020 Jun 2; 2020 May 13. PMID: 32404426.", + "Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells. Hoffman DP, Shtengel G, Xu CS, Campbell KR, Freeman M, Wang L, Milkie DE, Pasolli HA, Iyer N, Bogovic JA, Stabley DR, Shirinifard A, Pang S, Peale D, Schaefer K, Pomp W, Chang CL, Lippincott-Schwartz J, Kirchhausen T, Solecki DJ, Betzig E, Hess HF. Science. 2020 Jan 17. PMID: 31949053.", + "Publisher Correction: Gas cluster ion beam SEM for imaging of large tissue samples with 10 nm isotropic resolution. Hayworth KJ, Peale D, Januszewski M, Knott GW, Lu Z, Xu CS, Hess HF. Nat Methods. 2020 Jan. PMID: 31802009.", + "Gas cluster ion beam SEM for imaging of large tissue samples with 10 nm isotropic resolution. Hayworth KJ, Peale D, Januszewski M, Knott GW, Lu Z, Xu CS, Hess HF. Nat Methods. 2020 Jan; 2019 Nov 18. PMID: 31740820.", + "Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III. Chang CL, Weigel AV, Ioannou MS, Pasolli HA, Xu CS, Peale DR, Shtengel G, Freeman M, Hess HF, Blackstone C, Lippincott-Schwartz J. J Cell Biol. 2019 Aug 5; 2019 Jun 21. PMID: 31227594.", + "Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity. Ioannou MS, Jackson J, Sheu SH, Chang CL, Weigel AV, Liu H, Pasolli HA, Xu CS, Pang S, Matthies D, Hess HF, Lippincott-Schwartz J, Liu Z. Cell. 2019 May 30; 2019 May 23. PMID: 31130380.", + "Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution. Gao R, Asano SM, Upadhyayula S, Pisarev I, Milkie DE, Liu TL, Singh V, Graves A, Huynh GH, Zhao Y, Bogovic J, Colonell J, Ott CM, Zugates C, Tappan S, Rodriguez A, Mosaliganti KR, Sheu SH, Pasolli HA, Pang S, Xu CS, Megason SG, Hess H, Lippincott-Schwartz J, Hantman A, Rubin GM, Kirchhausen T, Saalfeld S, Aso Y, Boyden ES, Betzig E. Science. 2019 Jan 18. PMID: 30655415.", + "Comparisons between the ON- and OFF-edge motion pathways in the Drosophila brain. Shinomiya K, Huang G, Lu Z, Parag T, Xu CS, Aniceto R, Ansari N, Cheatham N, Lauchie S, Neace E, Ogundeyi O, Ordish C, Peel D, Shinomiya A, Smith C, Takemura S, Talebi I, Rivlin PK, Nern A, Scheffer LK, Plaza SM, Meinertzhagen IA. Elife. 2019 Jan 9; 2019 Jan 9. PMID: 30624205.", + "A resource for the Drosophila antennal lobe provided by the connectome of glomerulus VA1v. Horne JA, Langille C, McLin S, Wiederman M, Lu Z, Xu CS, Plaza SM, Scheffer LK, Hess HF, Meinertzhagen IA. Elife. 2018 Nov 1; 2018 Nov 1. PMID: 30382940.", + "The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles. Coulter ME, Dorobantu CM, Lodewijk GA, Delalande F, Cianferani S, Ganesh VS, Smith RS, Lim ET, Xu CS, Pang S, Wong ET, Lidov HGW, Calicchio ML, Yang E, Gonzalez DM, Schlaeger TM, Mochida GH, Hess H, Lee WA, Lehtinen MK, Kirchhausen T, Haussler D, Jacobs FMJ, Gaudin R, Walsh CA. Cell Rep. 2018 Jul 24. PMID: 30044992.", + "A novel sheet-like virus particle array is a hallmark of Zika virus infection. Liu J, Kline BA, Kenny TA, Smith DR, Soloveva V, Beitzel B, Pang S, Lockett S, Hess HF, Palacios G, Kuhn JH, Sun MG, Zeng X. Emerg Microbes Infect. 2018 Apr 25; 2018 Apr 25. PMID: 29691373.", + "A connectome of a learning and memory center in the adult Drosophila brain. Takemura SY, Aso Y, Hige T, Wong A, Lu Z, Xu CS, Rivlin PK, Hess H, Zhao T, Parag T, Berg S, Huang G, Katz W, Olbris DJ, Plaza S, Umayam L, Aniceto R, Chang LA, Lauchie S, Ogundeyi O, Ordish C, Shinomiya A, Sigmund C, Takemura S, Tran J, Turner GC, Rubin GM, Scheffer LK. Elife. 2017 Jul 18; 2017 Jul 18. PMID: 28718765.", + "Contacts between the endoplasmic reticulum and other membranes in neurons. Wu Y, Whiteus C, Xu CS, Hayworth KJ, Weinberg RJ, Hess HF, De Camilli P. Proc Natl Acad Sci U S A. 2017 Jun 13; 2017 May 30. PMID: 28559323.", + "Enhanced FIB-SEM systems for large-volume 3D imaging. Xu CS, Hayworth KJ, Lu Z, Grob P, Hassan AM, García-Cerdán JG, Niyogi KK, Nogales E, Weinberg RJ, Hess HF. Elife. 2017 May 13; 2017 May 13. PMID: 28500755.", + "Diverse protocols for correlative super-resolution fluorescence imaging and electron microscopy of chemically fixed samples. Kopek BG, Paez-Segala MG, Shtengel G, Sochacki KA, Sun MG, Wang Y, Xu CS, van Engelenburg SB, Taraska JW, Looger LL, Hess HF. Nat Protoc. 2017 May; 2017 Apr 6. PMID: 28384138.", + "Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER. Nixon-Abell J, Obara CJ, Weigel AV, Li D, Legant WR, Xu CS, Pasolli HA, Harvey K, Hess HF, Betzig E, Blackstone C, Lippincott-Schwartz J. Science. 2016 Oct 28; 2016 Oct 27. PMID: 27789813.", + "Synaptic circuits and their variations within different columns in the visual system of Drosophila. Takemura SY, Xu CS, Lu Z, Rivlin PK, Parag T, Olbris DJ, Plaza S, Zhao T, Katz WT, Umayam L, Weaver C, Hess HF, Horne JA, Nunez-Iglesias J, Aniceto R, Chang LA, Lauchie S, Nasca A, Ogundeyi O, Sigmund C, Takemura S, Tran J, Langille C, Le Lacheur K, McLin S, Shinomiya A, Chklovskii DB, Meinertzhagen IA, Scheffer LK. Proc Natl Acad Sci U S A. 2015 Nov 3; 2015 Oct 19. PMID: 26483464.", + "Ultrastructurally smooth thick partitioning and volume stitching for large-scale connectomics. Hayworth KJ, Xu CS, Lu Z, Knott GW, Fetter RD, Tapia JC, Lichtman JW, Hess HF. Nat Methods. 2015 Apr; 2015 Feb 16. PMID: 25686390.", + "Rab3A mediates vesicle delivery at photoreceptor ribbon synapses. Tian M, Xu CS, Montpetit R, Kramer RH. J Neurosci. 2012 May 16. PMID: 22593061.", + "Correlative 3D superresolution fluorescence and electron microscopy reveal the relationship of mitochondrial nucleoids to membranes. Kopek BG, Shtengel G, Xu CS, Clayton DA, Hess HF. Proc Natl Acad Sci U S A. 2012 Apr 17; 2012 Apr 2. PMID: 22474357.", + "Observation of spectral anisotropy of gold nanoparticles. Cang H, Montiel D, Xu CS, Yang H. J Chem Phys. 2008 Jul 28. PMID: 18681656.", + "Joint statistical analysis of multichannel time series from single quantum dot-(Cy5)n constructs. Xu CS, Kim H, Hayden CC, Yang H. J Phys Chem B. 2008 May 15; 2007 Dec 21. PMID: 18095665.", + "Guiding a confocal microscope by single fluorescent nanoparticles. Cang H, Xu CS, Montiel D, Yang H. Opt Lett. 2007 Sep 15. PMID: 17873950.", + "Multiparameter fluorescence spectroscopy of single quantum dot-dye FRET hybrids. Xu CS, Kim H, Yang H, Hayden CC. J Am Chem Soc. 2007 Sep 12; 2007 Aug 18. PMID: 17705496.", + "Hayworth KJ, Hess HF, Xu CS , Peale D. Volume scanning electron microscopy of serial thick tissue sections with gas cluster milling. US Patent No. 11,177,110, November, 2021.", + "Xu CS , Hayworth KJ, Hess HF. Enhanced FIB-SEM systems for large-volume 3D imaging. US Patent No. 10,600,615, March, 2020.", + "Yang H, Cang H, Xu CS , Wong CM. Single nanoparticle tracking spectroscopic microscope. US Patent No. 7,982,194, July, 2011.", + "de la Llera A, Pham X, Xu CS , Wei D, Luong T. Air platen for leading edge and trailing edge control. US Patent No. 7,018,276, March, 2006.", + "Yi J, Xu CS . Neural network control of chemical mechanical planarization. US Patent No. 7,001,243, February, 2006.", + "Taylor TR, Xu CS . Apparatus for edge polishing uniformity control. US Patent No. 6,991,512, January, 2006.", + "Majumder SA, Xu CS , Chen Z. Methods for reducing slurry usage in a linear chemical mechanical planarization system. US Patent No. 6,953,391, October, 2005.", + "Xu CS , Zhao EY, Dai F. Methods for making reinforced wafer polishing pads and apparatuses implementing the same. US Patent No. 6,949,020, September, 2005.", + "Yi J, Xu CS . Methods for monitoring and controlling chemical mechanical planarization. US Patent No. 6,931,330, August, 2005.", + "Yi J, Xu CS . End point detection with imaging matching in semiconductor processing. US Patent No. 6,930,782, August, 2005.", + "Xu CS , Wu P, Pham X. Molded end point detection window for chemical mechanical planarization. US Patent No. 6,806,100, October, 2004.", + "Taylor TR, Xu CS . Fluid conserving platen for optimizing edge polishing. 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Methods for making reinforced wafer polishing pads and apparatuses implementing the same. US Patent No. 6,561,889, May, 2003.", + "Xu CS , Zhao Y. Method and system for measuring threshold length. US Patent No. 6,552,812, April, 2003.", + "Pang S , Tong L, Dong Z, Lin K, Hsiang J, Data storage and retrieval apparatus with thin film read head having planarized extra gap and shield layers and method of fabrication thereof, US Patent 6,496,334, December 17, 2002.", + "Xu CS , Lombardo BS. Unsupported chemical mechanical polishing belt. US Patent No. 6,406,363, June, 2002.", + "Wang L, Shi Z, Hossain S, Pang S , Advanced pole trim writer with moment P1 and low apex angle, US Patent 6,317,290, November 13, 2001.", + "Jensen A, Xu CS . Method of optimizing chemical mechanical planarization process. US Patent No. 6,315,634, November, 2001.", + "333 Cedar Street New Haven, CT 06510 Maps & Directions", + "312 Events you could attend in November 2025 Calendar", + "Contact Us", + "", + "", + "", + "", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Calderwood Lab", + "lab_url": "https://medicine.yale.edu/lab/calderwood/", + "research_bio": "INFORMATION FOR The ability of cells to sense, adhere to and remodel the extracellular matrix that surrounds them is essential for multi-cellular life. The broad goal of research in the Calderwood lab is to understand the molecular basis of signaling to and from integrin adhesion receptors. We use a combination of structural, biochemical and cell biological approaches to investigate how integrin-associated intracellular proteins regulate integrin activation state, provide links from integrins to the actin cytoskeleton, control cell migration and morphogenesis, and assemble into signaling complexes. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/calderwood/publications/", + "publications": [ + "Yale School of Medicine /", + "Pharmacology /", + "Research", + "Event Photos", + "Publications", + "Lab Members Alumni", + "Alumni", + "Structures Videos", + "Videos", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Publications", + "Lab Members", + "Structures", + "Event Photos", + "", + "", + "", + "", + "", + "", + "Sugar unmasking for trafficking. Calderwood DA, Toomre D. Nat Cell Biol. 2025 Mar. PMID: 40038537.", + "Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma. McGeary MK, Damsky W, Daniels AJ, Lang SM, Xu Q, Song E, Huet-Calderwood C, Lou HJ, Paradkar S, Micevic G, Kaech SM, Calderwood DA, Turk BE, Yan Q, Iwasaki A, Bosenberg MW. Cancer Immunol Res. 2025 Feb 3. PMID: 39589394.", + "The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8(+) T cells. Liao X, Li W, Zhou H, Rajendran BK, Li A, Ren J, Luan Y, Calderwood DA, Turk B, Tang W, Liu Y, Wu D. Nat Commun. 2024 Jan 19; 2024 Jan 19. PMID: 38242867.", + "Intracellular tension sensor reveals mechanical anisotropy of the actin cytoskeleton. Amiri S, Muresan C, Shang X, Huet-Calderwood C, Schwartz MA, Calderwood DA, Murrell M. Nat Commun. 2023 Dec 4; 2023 Dec 4. PMID: 38049429.", + "Author Correction: Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4). Ha BH, Yigit S, Natarajan N, Morse EM, Calderwood DA, Boggon TJ. Commun Biol. 2023 Jul 31; 2023 Jul 31. PMID: 37524913.", + "Setdb1 -loss induces type-I interferons and immune clearance of melanoma. McGeary MK, Damsky W, Daniels A, Song E, Micevic G, Huet-Calderwood C, Lou HJ, Paradkar S, Kaech S, Calderwood DA, Turk BE, Iwasaki A, Bosenberg MW. bioRxiv. 2023 May 24; 2023 May 24. PMID: 37292991.", + "Fibroblasts secrete fibronectin under lamellipodia in a microtubule- and myosin II-dependent fashion. Huet-Calderwood C, Rivera-Molina FE, Toomre DK, Calderwood DA. J Cell Biol. 2023 Feb 6; 2022 Nov 23. PMID: 36416725.", + "Organization, dynamics and mechanoregulation of integrin-mediated cell-ECM adhesions. Kanchanawong P, Calderwood DA. Nat Rev Mol Cell Biol. 2023 Feb; 2022 Sep 27. PMID: 36168065.", + "Use of Ecto-Tagged Integrins to Monitor Integrin Exocytosis and Endocytosis. Huet-Calderwood C, Rivera-Molina F, Toomre D, Calderwood DA. Methods Mol Biol. 2023. PMID: 36653699.", + "Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4). Ha BH, Yigit S, Natarajan N, Morse EM, Calderwood DA, Boggon TJ. Commun Biol. 2022 Nov 17; 2022 Nov 17. PMID: 36385162.", + "Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry. Simon B, Lou HJ, Huet-Calderwood C, Shi G, Boggon TJ, Turk BE, Calderwood DA. Nat Commun. 2022 Feb 8; 2022 Feb 8. PMID: 35136069.", + "A Small-Scale shRNA Screen in Primary Mouse Macrophages Identifies a Role for the Rab GTPase Rab1b in Controlling Salmonella Typhi Growth. Solano-Collado V, Colamarino RA, Calderwood DA, Baldassarre M, Spanò S. Front Cell Infect Microbiol. 2021; 2021 Apr 7. PMID: 33898333.", + "PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK. Cho E, Lou HJ, Kuruvilla L, Calderwood DA, Turk BE. Cell Rep. 2021 Mar 30. PMID: 33789117.", + "Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association. Zhou M, Kuruvilla L, Shi X, Viviano S, Ahearn IM, Amendola CR, Su W, Badri S, Mahaffey J, Fehrenbacher N, Skok J, Schlessinger J, Turk BE, Calderwood DA, Philips MR. Proc Natl Acad Sci U S A. 2020 Dec 15; 2020 Nov 30. PMID: 33257571.", + "Signalling through cerebral cavernous malformation protein networks. Su VL, Calderwood DA. Open Biol. 2020 Nov; 2020 Nov 25. PMID: 33234067.", + "Differences in self-association between kindlin-2 and kindlin-3 are associated with differential integrin binding. Kadry YA, Maisuria EM, Huet-Calderwood C, Calderwood DA. J Biol Chem. 2020 Aug 7; 2020 Jun 16. PMID: 32546480.", + "Chapter 22: Structural and signaling functions of integrins. Kadry YA, Calderwood DA. Biochim Biophys Acta Biomembr. 2020 May 1; 2020 Jan 25. PMID: 31991120.", + "Serine phosphorylation of the small phosphoprotein ICAP1 inhibits its nuclear accumulation. Su VL, Simon B, Draheim KM, Calderwood DA. J Biol Chem. 2020 Mar 6; 2020 Jan 31. PMID: 32005669.", + "The subcellular localization of type I p21-activated kinases is controlled by the disordered variable region and polybasic sequences. Sun X, Su VL, Calderwood DA. J Biol Chem. 2019 Sep 27; 2019 Aug 7. PMID: 31391252.", + "Filamin A mediates isotropic distribution of applied force across the actin network. Kumar A, Shutova MS, Tanaka K, Iwamoto DV, Calderwood DA, Svitkina TM, Schwartz MA. J Cell Biol. 2019 Aug 5; 2019 Jul 17. PMID: 31315944.", + "Coarse-Grained Simulation of Full-Length Integrin Activation. Bidone TC, Polley A, Jin J, Driscoll T, Iwamoto DV, Calderwood DA, Schwartz MA, Voth GA. Biophys J. 2019 Mar 19; 2019 Feb 22. PMID: 30851876.", + "Kindlin-2 interacts with a highly conserved surface of ILK to regulate focal adhesion localization and cell spreading. Kadry YA, Huet-Calderwood C, Simon B, Calderwood DA. J Cell Sci. 2018 Oct 26; 2018 Oct 26. PMID: 30254023.", + "Structural basis of the filamin A actin-binding domain interaction with F-actin. Iwamoto DV, Huehn A, Simon B, Huet-Calderwood C, Baldassarre M, Sindelar CV, Calderwood DA. Nat Struct Mol Biol. 2018 Oct; 2018 Sep 17. PMID: 30224736.", + "Novel ecto-tagged integrins reveal their trafficking in live cells. Huet-Calderwood C, Rivera-Molina F, Iwamoto DV, Kromann EB, Toomre D, Calderwood DA. Nat Commun. 2017 Sep 18; 2017 Sep 18. PMID: 28924207.", + "Nuclear Localization of Integrin Cytoplasmic Domain-associated Protein-1 (ICAP1) Influences β1 Integrin Activation and Recruits Krev/Interaction Trapped-1 (KRIT1) to the Nucleus. Draheim KM, Huet-Calderwood C, Simon B, Calderwood DA. J Biol Chem. 2017 Feb 3; 2016 Dec 21. PMID: 28003363.", + "Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms. Shi X, Mihaylova VT, Kuruvilla L, Chen F, Viviano S, Baldassarre M, Sperandio D, Martinez R, Yue P, Bates JG, Breckenridge DG, Schlessinger J, Turk BE, Calderwood DA. Proc Natl Acad Sci U S A. 2016 Aug 2; 2016 Jul 18. PMID: 27432991.", + "PAK6 targets to cell-cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape. Morse EM, Sun X, Olberding JR, Ha BH, Boggon TJ, Calderwood DA. J Cell Sci. 2016 Jan 15; 2015 Nov 23. PMID: 26598554.", + "The Rap1-RIAM pathway prefers β2 integrins. Calderwood DA. Blood. 2015 Dec 17. PMID: 26679542.", + "Regulation of integrin-mediated adhesions. Iwamoto DV, Calderwood DA. Curr Opin Cell Biol. 2015 Oct; 2015 Jul 17. PMID: 26189062.", + "CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation. Draheim KM, Li X, Zhang R, Fisher OS, Villari G, Boggon TJ, Calderwood DA. J Cell Biol. 2015 Mar 30. PMID: 25825518.", + "Direct interactions with the integrin β1 cytoplasmic tail activate the Abl2/Arg kinase. Simpson MA, Bradley WD, Harburger D, Parsons M, Calderwood DA, Koleske AJ. J Biol Chem. 2015 Mar 27; 2015 Feb 18. PMID: 25694433.", + "Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function. Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood DA, Schwartz M, Simons M, Sessa WC, Kyriakides TR. J Biol Chem. 2015 Jan 2; 2014 Nov 11. PMID: 25389299.", + "The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering. Ellis SJ, Lostchuck E, Goult BT, Bouaouina M, Fairchild MJ, López-Ceballos P, Calderwood DA, Tanentzapf G. PLoS Genet. 2014 Nov; 2014 Nov 13. PMID: 25393120.", + "Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation. Huet-Calderwood C, Brahme NN, Kumar N, Stiegler AL, Raghavan S, Boggon TJ, Calderwood DA. J Cell Sci. 2014 Oct 1; 2014 Aug 1. PMID: 25086068.", + "TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly. Uchil PD, Pawliczek T, Reynolds TD, Ding S, Hinz A, Munro JB, Huang F, Floyd RW, Yang H, Hamilton WL, Bewersdorf J, Xiong Y, Calderwood DA, Mothes W. J Cell Sci. 2014 Sep 15; 2014 Jul 11. PMID: 25015296.", + "Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis. Lee MY, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano AK, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood DA, Ferguson SM, De Camilli P, Sessa WC. Development. 2014 Apr; 2014 Mar 5. PMID: 24598168.", + "Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance. Tian X, Kim JJ, Monkley SM, Gotoh N, Nandez R, Soda K, Inoue K, Balkin DM, Hassan H, Son SH, Lee Y, Moeckel G, Calderwood DA, Holzman LB, Critchley DR, Zent R, Reiser J, Ishibe S. J Clin Invest. 2014 Mar; 2014 Feb 17. PMID: 24531545.", + "Cerebral cavernous malformation proteins at a glance. Draheim KM, Fisher OS, Boggon TJ, Calderwood DA. J Cell Sci. 2014 Feb 15; 2014 Jan 30. PMID: 24481819.", + "Integrin cytoplasmic tail interactions. Morse EM, Brahme NN, Calderwood DA. Biochemistry. 2014 Feb 11; 2014 Jan 27. PMID: 24467163.", + "Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics. Brahme NN, Harburger DS, Kemp-O'Brien K, Stewart R, Raghavan S, Parsons M, Calderwood DA. J Biol Chem. 2013 Dec 6; 2013 Oct 28. PMID: 24165133.", + "ASB2α, an E3 ubiquitin ligase specificity subunit, regulates cell spreading and triggers proteasomal degradation of filamins by targeting the filamin calponin homology 1 domain. Razinia Z, Baldassarre M, Cantelli G, Calderwood DA. J Biol Chem. 2013 Nov 1; 2013 Sep 19. PMID: 24052262.", + "Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6. Gao J, Ha BH, Lou HJ, Morse EM, Zhang R, Calderwood DA, Turk BE, Boggon TJ. PLoS One. 2013; 2013 Oct 28. PMID: 24204982.", + "Talins and kindlins: partners in integrin-mediated adhesion. Calderwood DA, Campbell ID, Critchley DR. Nat Rev Mol Cell Biol. 2013 Aug; 2013 Jul 17. PMID: 23860236.", + "Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation. Liu W, Draheim KM, Zhang R, Calderwood DA, Boggon TJ. Mol Cell. 2013 Feb 21; 2013 Jan 11. PMID: 23317506.", + "Purification and SAXS analysis of the integrin linked kinase, PINCH, parvin (IPP) heterotrimeric complex. Stiegler AL, Grant TD, Luft JR, Calderwood DA, Snell EH, Boggon TJ. PLoS One. 2013; 2013 Jan 31. PMID: 23383235.", + "Structural and functional characterization of the kindlin-1 pleckstrin homology domain. Yates LA, Lumb CN, Brahme NN, Zalyte R, Bird LE, De Colibus L, Owens RJ, Calderwood DA, Sansom MS, Gilbert RJ. J Biol Chem. 2012 Dec 21; 2012 Nov 6. PMID: 23132860.", + "Zasp regulates integrin activation. Bouaouina M, Jani K, Long JY, Czerniecki S, Morse EM, Ellis SJ, Tanentzapf G, Schöck F, Calderwood DA. J Cell Sci. 2012 Dec 1; 2012 Sep 19. PMID: 22992465.", + "Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension. Coyer SR, Singh A, Dumbauld DW, Calderwood DA, Craig SW, Delamarche E, García AJ. J Cell Sci. 2012 Nov 1; 2012 Aug 16. PMID: 22899715.", + "Structural basis for paxillin binding and focal adhesion targeting of β-parvin. Stiegler AL, Draheim KM, Li X, Chayen NE, Calderwood DA, Boggon TJ. J Biol Chem. 2012 Sep 21; 2012 Aug 6. PMID: 22869380.", + "Cell adhesion: a FERM grasp of the tail sorts out integrins. Brahme NN, Calderwood DA. Curr Biol. 2012 Sep 11. PMID: 22974999.", + "Filamin A controls matrix metalloproteinase activity and regulates cell invasion in human fibrosarcoma cells. Baldassarre M, Razinia Z, Brahme NN, Buccione R, Calderwood DA. J Cell Sci. 2012 Aug 15; 2012 May 17. PMID: 22595522.", + "Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1). Li X, Zhang R, Draheim KM, Liu W, Calderwood DA, Boggon TJ. J Biol Chem. 2012 Jun 22; 2012 May 10. PMID: 22577140.", + "Functional differences between kindlin-1 and kindlin-2 in keratinocytes. Bandyopadhyay A, Rothschild G, Kim S, Calderwood DA, Raghavan S. J Cell Sci. 2012 May 1; 2012 Feb 10. PMID: 22328497.", + "Macrophage mesenchymal migration requires podosome stabilization by filamin A. Guiet R, Vérollet C, Lamsoul I, Cougoule C, Poincloux R, Labrousse A, Calderwood DA, Glogauer M, Lutz PG, Maridonneau-Parini I. J Biol Chem. 2012 Apr 13; 2012 Feb 9. PMID: 22334688.", + "A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation. Bouaouina M, Goult BT, Huet-Calderwood C, Bate N, Brahme NN, Barsukov IL, Critchley DR, Calderwood DA. J Biol Chem. 2012 Mar 2; 2012 Jan 10. PMID: 22235127.", + "FAK promotes recruitment of talin to nascent adhesions to control cell motility. Lawson C, Lim ST, Uryu S, Chen XL, Calderwood DA, Schlaepfer DD. J Cell Biol. 2012 Jan 23. PMID: 22270917.", + "Filamins in mechanosensing and signaling. Razinia Z, Mäkelä T, Ylänne J, Calderwood DA. Annu Rev Biophys. 2012; 2012 Feb 23. PMID: 22404683.", + "Talin and signaling through integrins. Bouaouina M, Harburger DS, Calderwood DA. Methods Mol Biol. 2012. PMID: 21909921.", + "Functional and structural insights into ASB2alpha, a novel regulator of integrin-dependent adhesion of hematopoietic cells. Lamsoul I, Burande CF, Razinia Z, Houles TC, Menoret D, Baldassarre M, Erard M, Moog-Lutz C, Calderwood DA, Lutz PG. J Biol Chem. 2011 Sep 2; 2011 Jul 7. PMID: 21737450.", + "The E3 ubiquitin ligase specificity subunit ASB2α targets filamins for proteasomal degradation by interacting with the filamin actin-binding domain. Razinia Z, Baldassarre M, Bouaouina M, Lamsoul I, Lutz PG, Calderwood DA. J Cell Sci. 2011 Aug 1; 2011 Jul 12. PMID: 21750192.", + "Kindlins. Bouaouina M, Calderwood DA. Curr Biol. 2011 Feb 8. PMID: 21300280.", + "Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase. Chiswell BP, Stiegler AL, Razinia Z, Nalibotski E, Boggon TJ, Calderwood DA. J Struct Biol. 2010 Apr; 2009 Dec 4. PMID: 19963065.", + "Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation. Goult BT, Bouaouina M, Elliott PR, Bate N, Patel B, Gingras AR, Grossmann JG, Roberts GC, Calderwood DA, Critchley DR, Barsukov IL. EMBO J. 2010 Mar 17; 2010 Feb 11. PMID: 20150896.", + "The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation. Goult BT, Bouaouina M, Harburger DS, Bate N, Patel B, Anthis NJ, Campbell ID, Calderwood DA, Barsukov IL, Roberts GC, Critchley DR. J Mol Biol. 2009 Dec 18; 2009 Oct 3. PMID: 19804783.", + "Filamins regulate cell spreading and initiation of cell migration. Baldassarre M, Razinia Z, Burande CF, Lamsoul I, Lutz PG, Calderwood DA. PLoS One. 2009 Nov 13; 2009 Nov 13. PMID: 19915675.", + "Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension. Gehler S, Baldassarre M, Lad Y, Leight JL, Wozniak MA, Riching KM, Eliceiri KW, Weaver VM, Calderwood DA, Keely PJ. Mol Biol Cell. 2009 Jul; 2009 May 20. PMID: 19458194.", + "The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation. Bello NF, Lamsoul I, Heuzé ML, Métais A, Moreaux G, Calderwood DA, Duprez D, Moog-Lutz C, Lutz PG. Cell Death Differ. 2009 Jun; 2009 Mar 20. PMID: 19300455.", + "Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects. Harburger DS, Bouaouina M, Calderwood DA. J Biol Chem. 2009 Apr 24; 2009 Feb 23. PMID: 19240021.", + "The role of FilGAP-filamin A interactions in mechanoprotection. Shifrin Y, Arora PD, Ohta Y, Calderwood DA, McCulloch CA. Mol Biol Cell. 2009 Mar; 2009 Jan 14. PMID: 19144823.", + "Integrin signalling at a glance. Harburger DS, Calderwood DA. J Cell Sci. 2009 Jan 15. PMID: 19118207.", + "The structural basis of integrin-linked kinase-PINCH interactions. Chiswell BP, Zhang R, Murphy JW, Boggon TJ, Calderwood DA. Proc Natl Acad Sci U S A. 2008 Dec 30; 2008 Dec 12. PMID: 19074270.", + "JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation. Luissint AC, Lutz PG, Calderwood DA, Couraud PO, Bourdoulous S. J Cell Biol. 2008 Dec 15; 2008 Dec 8. PMID: 19064666.", + "ASB2 targets filamins A and B to proteasomal degradation. Heuzé ML, Lamsoul I, Baldassarre M, Lad Y, Lévêque S, Razinia Z, Moog-Lutz C, Calderwood DA, Lutz PG. Blood. 2008 Dec 15; 2008 Sep 17. PMID: 18799729.", + "Structural basis of the migfilin-filamin interaction and competition with integrin beta tails. Lad Y, Jiang P, Ruskamo S, Harburger DS, Ylänne J, Campbell ID, Calderwood DA. J Biol Chem. 2008 Dec 12; 2008 Sep 30. PMID: 18829455.", + "The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate beta1 and beta3 integrins. Bouaouina M, Lad Y, Calderwood DA. J Biol Chem. 2008 Mar 7; 2007 Dec 28. PMID: 18165225.", + "Structure of three tandem filamin domains reveals auto-inhibition of ligand binding. Lad Y, Kiema T, Jiang P, Pentikäinen OT, Coles CH, Campbell ID, Calderwood DA, Ylänne J. EMBO J. 2007 Sep 5; 2007 Aug 9. PMID: 17690686.", + "Forces and bond dynamics in cell adhesion. Evans EA, Calderwood DA. Science. 2007 May 25. PMID: 17525329.", + "Integrin cytoskeletal interactions. Lad Y, Harburger DS, Calderwood DA. Methods Enzymol. 2007. PMID: 17697880.", + "Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Han J, Lim CJ, Watanabe N, Soriani A, Ratnikov B, Calderwood DA, Puzon-McLaughlin W, Lafuente EM, Boussiotis VA, Shattil SJ, Ginsberg MH. Curr Biol. 2006 Sep 19. PMID: 16979556.", + "Integrins in the ovary. Monniaux D, Huet-Calderwood C, Le Bellego F, Fabre S, Monget P, Calderwood DA. Semin Reprod Med. 2006 Sep. PMID: 16944422.", + "The molecular basis of filamin binding to integrins and competition with talin. Kiema T, Lad Y, Jiang P, Oxley CL, Baldassarre M, Wegener KL, Campbell ID, Ylänne J, Calderwood DA. Mol Cell. 2006 Feb 3. PMID: 16455489.", + "Competition for talin results in trans-dominant inhibition of integrin activation. Calderwood DA, Tai V, Di Paolo G, De Camilli P, Ginsberg MH. J Biol Chem. 2004 Jul 9; 2004 May 13. PMID: 15143061.", + "Talin controls integrin activation. Calderwood DA. Biochem Soc Trans. 2004 Jun. PMID: 15157154.", + "The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. Kloeker S, Major MB, Calderwood DA, Ginsberg MH, Jones DA, Beckerle MC. J Biol Chem. 2004 Feb 20; 2003 Nov 21. PMID: 14634021.", + "Integrin activation. Calderwood DA. J Cell Sci. 2004 Feb 15. PMID: 14754902.", + "Talin binding to integrin beta tails: a final common step in integrin activation. Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, de Pereda JM, Ginsberg MH, Calderwood DA. Science. 2003 Oct 3. PMID: 14526080.", + "Talin forges the links between integrins and actin. Calderwood DA, Ginsberg MH. Nat Cell Biol. 2003 Aug. PMID: 12894175.", + "Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit. Ulmer TS, Calderwood DA, Ginsberg MH, Campbell ID. Biochemistry. 2003 Jul 15. PMID: 12846579.", + "Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Calderwood DA, Fujioka Y, de Pereda JM, García-Alvarez B, Nakamoto T, Margolis B, McGlade CJ, Liddington RC, Ginsberg MH. Proc Natl Acad Sci U S A. 2003 Mar 4; 2003 Feb 26. PMID: 12606711.", + "Structural determinants of integrin recognition by talin. García-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC. Mol Cell. 2003 Jan. PMID: 12535520.", + "The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains. Woodside DG, Obergfell A, Talapatra A, Calderwood DA, Shattil SJ, Ginsberg MH. J Biol Chem. 2002 Oct 18; 2002 Aug 8. PMID: 12171941.", + "The phosphotyrosine binding-like domain of talin activates integrins. Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, Liddington RC, Ginsberg MH. J Biol Chem. 2002 Jun 14; 2002 Apr 3. PMID: 11932255.", + "Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration. Calderwood DA, Huttenlocher A, Kiosses WB, Rose DM, Woodside DG, Schwartz MA, Ginsberg MH. Nat Cell Biol. 2001 Dec. PMID: 11781567.", + "PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase. Formstecher E, Ramos JW, Fauquet M, Calderwood DA, Hsieh JC, Canton B, Nguyen XT, Barnier JV, Camonis J, Ginsberg MH, Chneiweiss H. Dev Cell. 2001 Aug. PMID: 11702783.", + "Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain. Yan B, Calderwood DA, Yaspan B, Ginsberg MH. J Biol Chem. 2001 Jul 27; 2001 May 29. PMID: 11382782.", + "Distinct domains of CD98hc regulate integrins and amino acid transport. Fenczik CA, Zent R, Dellos M, Calderwood DA, Satriano J, Kelly C, Ginsberg MH. J Biol Chem. 2001 Mar 23; 2000 Dec 19. PMID: 11121428.", + "Integrin cytoplasmic domain-binding proteins. Liu S, Calderwood DA, Ginsberg MH. J Cell Sci. 2000 Oct. PMID: 11017872.", + "Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling. Calderwood DA, Shattil SJ, Ginsberg MH. J Biol Chem. 2000 Jul 28. PMID: 10801899.", + "Class- and splice variant-specific association of CD98 with integrin beta cytoplasmic domains. Zent R, Fenczik CA, Calderwood DA, Liu S, Dellos M, Ginsberg MH. J Biol Chem. 2000 Feb 18. PMID: 10671548.", + "The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. Calderwood DA, Zent R, Grant R, Rees DJ, Hynes RO, Ginsberg MH. J Biol Chem. 1999 Oct 1. PMID: 10497155.", + "Sterling Hall of Medicine 333 Cedar Street PO Box 208066 New Haven, CT 06520-8066", + "Calendar", + "Contact Us", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "CAMS Lab", + "lab_url": "https://medicine.yale.edu/lab/goldfarb/", + "research_bio": "INFORMATION FOR We study why we remember certain parts of our experiences, how stress and affect change different memories, and how what we remember guides our behavior. The lab is led by Dr. Elizabeth Goldfarb. We are based in the Department of Psychiatry at theYale Stress Centerand conduct research at theYale Magnetic Resonance Research Center. We are committed to creating an inclusive, thoughtful, rewarding, and intellectually stimulating environment to conduct our research. We are actively recruiting participants for behavioral and brain imaging experiments in the laboratory. If you are interested in participating, please send an email or complete the form. Copy Link We have openings for undergraduate, graduate, and postdoctoral researchers! Please emailDr. Goldfarbwith your CV and interests for more information. Please note that we primarily accept graduate students through Yale’sInterdepartmental Neuroscience Program. In joining the lab, all members agree to promote and uphold the following values: Equal Opportunity and Nondiscrimination at Yale", + "publications_page": "https://medicine.yale.edu/lab/goldfarb/publications/", + "publications": [ + "Yale School of Medicine /", + "Psychiatry /", + "People", + "News", + "Research", + "Participate", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "People", + "Research", + "Participate", + "Publications", + "News", + "", + "", + "", + "", + "", + "", + "Trauma-predictive brain network connectivity adaptively responds to mild acute stress. Hardi FA, Ye J, Zhou I, Bai Z, Nguyen DT, Loetscher KB, Pratt JG, Harris BB, Gee DG, Goldfarb EV. Proc Natl Acad Sci U S A. 2025 Aug 5; 2025 Jul 30. PMID: 40737323.", + "Network state dynamics underpin basal craving in a transdiagnostic population. Ye J, Garrison KA, Lacadie C, Potenza MN, Sinha R, Goldfarb EV, Scheinost D. Mol Psychiatry. 2025 Feb; 2024 Aug 25. PMID: 39183336.", + "Positive affect amplifies integration within episodic memories in the laboratory and the real world. Pratt JG, Wemm SE, Harris BB, Huang Y, Sinha R, Goldfarb EV. Learn Mem. 2025 Jan; 2025 Jan 27. PMID: 39870487.", + "Drawbacks to Strengthening Neural Salience Encoding: A Link Between Cortisol and Risky Drinking. Harris BB, Sinha R, Goldfarb EV. J Neurosci. 2024 Oct 2; 2024 Oct 2. PMID: 39147591.", + "Acute Stress Effects on Statistical Learning and Episodic Memory. Sherman BE, Huang I, Wijaya EG, Turk-Browne NB, Goldfarb EV. J Cogn Neurosci. 2024 Jul 1. PMID: 38713878.", + "Integrating and fragmenting memories under stress and alcohol. Loetscher KB, Goldfarb EV. Neurobiol Stress. 2024 May; 2024 Feb 8. PMID: 38375503.", + "Acute Stress Enhances Memory and Preference for Smoking-Related Associations in Smokers. Lee JH, Kang S, Maier SU, Lee SA, Goldfarb EV, Ahn WY. Nicotine Tob Res. 2024 Feb 22. PMID: 37589502.", + "Multiple Memory Subsystems: Reconsidering Memory in the Mind and Brain. Sherman BE, Turk-Browne NB, Goldfarb EV. Perspect Psychol Sci. 2024 Jan; 2023 Jun 30. PMID: 37390333.", + "Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements. Sherman BE, Harris BB, Turk-Browne NB, Sinha R, Goldfarb EV. J Neurosci. 2023 Oct 25; 2023 Oct 9. PMID: 37813570.", + "Network state dynamics underpin craving in a transdiagnostic population. Ye J, Garrison KA, Lacadie C, Potenza MN, Sinha R, Goldfarb EV, Scheinost D. medRxiv. 2023 Oct 3; 2023 Oct 3. PMID: 37873309.", + "Perceptual Generalization of Alcohol-Related Value Characterizes Risky Drinkers. Kang S, Larrabee G, Nair S, Goldfarb EV. Psychol Sci. 2023 Oct; 2023 Sep 8. PMID: 37682597.", + "Binge drinking is associated with higher cortisol and lower hippocampal and prefrontal gray matter volume: Prospective association with future alcohol intake. Fan S, Goldfarb EV, Lacadie C, Fogelman N, Seo D, Sinha R. Neurobiol Stress. 2023 Jul; 2023 May 30. PMID: 37323647.", + "Understanding Posttraumatic Stress Disorder With Clues From the Dynamic Brain. Goldfarb EV. Biol Psychiatry Cogn Neurosci Neuroimaging. 2023 Apr. PMID: 37028902.", + "Hippocampal mechanisms support cortisol-induced memory enhancements. Sherman BE, Harris BB, Turk-Browne NB, Sinha R, Goldfarb EV. bioRxiv. 2023 Feb 9; 2023 Feb 9. PMID: 36798309.", + "High-Risk Drinkers Engage Distinct Stress-Predictive Brain Networks. Goldfarb EV, Scheinost D, Fogelman N, Seo D, Sinha R. Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Aug; 2022 Mar 7. PMID: 35272096.", + "Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events. Wendt FR, Warrier V, Pathak GA, Koenen KC, Stein MB, Krystal JH, Pietrzak RH, Gelernter J, Goldfarb EV, Baron-Cohen S, Polimanti R. Neurobiol Stress. 2022 Mar; 2022 Feb 21. PMID: 35242894.", + "Elemental and configural threat learning bias extinction generalization. Goldfarb EV, Blow T, Dunsmoor JE, Phelps EA. Neurobiol Learn Mem. 2021 Apr; 2021 Feb 18. PMID: 33609739.", + "Participant stress in the COVID-19 era and beyond. Goldfarb EV. Nat Rev Neurosci. 2020 Dec. PMID: 32978609.", + "Memory biases in alcohol use disorder: enhanced memory for contexts associated with alcohol prospectively predicts alcohol use outcomes. Goldfarb EV, Fogelman N, Sinha R. Neuropsychopharmacology. 2020 Jul; 2020 Mar 3. PMID: 32126569.", + "Hippocampal seed connectome-based modeling predicts the feeling of stress. Goldfarb EV, Rosenberg MD, Seo D, Constable RT, Sinha R. Nat Commun. 2020 May 27; 2020 May 27. PMID: 32461583.", + "Fighting the Return of Fear: Roles of Mindfulness-Based Stress Reduction and the Hippocampus. Goldfarb EV, Sinha R. Biol Psychiatry. 2019 Nov 1. PMID: 31601362.", + "Sex differences in neural stress responses and correlation with subjective stress and stress regulation. Goldfarb EV, Seo D, Sinha R. Neurobiol Stress. 2019 Nov; 2019 May 25. PMID: 31304198.", + "Enhancing memory with stress: Progress, challenges, and opportunities. Goldfarb EV. Brain Cogn. 2019 Jul; 2018 Dec 12. PMID: 30553573.", + "Acute stress throughout the memory cycle: Diverging effects on associative and item memory. Goldfarb EV, Tompary A, Davachi L, Phelps EA. J Exp Psychol Gen. 2019 Jan; 2018 Sep 17. PMID: 30221962.", + "Drug-Induced Glucocorticoids and Memory for Substance Use. Goldfarb EV, Sinha R. Trends Neurosci. 2018 Nov; 2018 Aug 28. PMID: 30170822.", + "Acute Stress Time-dependently Modulates Multiple Memory Systems. Goldfarb EV, Mendelevich Y, Phelps EA. J Cogn Neurosci. 2017 Nov; 2017 Jul 12. PMID: 28699809.", + "Low lifetime stress exposure is associated with reduced stimulus-response memory. Goldfarb EV, Shields GS, Daw ND, Slavich GM, Phelps EA. Learn Mem. 2017 Apr; 2017 Mar 15. PMID: 28298555.", + "Stress and Cognitive Flexibility: Cortisol Increases Are Associated with Enhanced Updating but Impaired Switching. Goldfarb EV, Froböse MI, Cools R, Phelps EA. J Cogn Neurosci. 2017 Jan; 2016 Aug 30. PMID: 27576026.", + "Classifying emotion regulation strategies. Raio CM, Goldfarb EV, Lempert KM, Sokol-Hessner P. Nat Rev Neurosci. 2016 Aug; 2016 Jun 9. PMID: 27277870.", + "Memory-Guided Attention: Independent Contributions of the Hippocampus and Striatum. Goldfarb EV, Chun MM, Phelps EA. Neuron. 2016 Jan 20. PMID: 26777274.", + "Gaps in preparedness of clergy and healthcare providers to address mental health needs of returning service members. Chevalier L, Goldfarb E, Miller J, Hoeppner B, Gorrindo T, Birnbaum RJ. J Relig Health. 2015 Feb. PMID: 25112409.", + "Autonomic arousal and learning in Web-based simulation: a feasibility study. Gorrindo T, Chevalier L, Goldfarb E, Hoeppner BB, Birnbaum RJ. J Contin Educ Health Prof. 2014 Spring. PMID: 24935879.", + "Interprofessional differences in disposition decisions: results from a standardized web-based patient assessment. Gorrindo T, Goldfarb E, Chevalier L, Hoeppner BB, Birnbaum RJ, Meller B, Alpert JE, Herman J, Weiss AP. Psychiatr Serv. 2013 Aug 1. PMID: 23903607.", + "Simulation-based ongoing professional practice evaluation in psychiatry: a novel tool for performance assessment. Gorrindo T, Goldfarb E, Birnbaum RJ, Chevalier L, Meller B, Alpert J, Herman J, Weiss A. Jt Comm J Qual Patient Saf. 2013 Jul. PMID: 23888642.", + "Enhancing informed consent best practices: gaining patient, family and provider perspectives using reverse simulation. Goldfarb E, Fromson JA, Gorrindo T, Birnbaum RJ. J Med Ethics. 2012 Sep; 2012 Apr 21. PMID: 22522147.", + "Attendees' perceptions of commercial influence in noncommercially funded CME programs. Goldfarb E, Baer L, Fromson JA, Gorrindo T, Iodice KE, Birnbaum RJ. J Contin Educ Health Prof. 2012 Summer. PMID: 23008083.", + "Implementation of a screen and treat program for child posttraumatic stress disorder in a school setting after a school suicide. Charuvastra A, Goldfarb E, Petkova E, Cloitre M. J Trauma Stress. 2010 Aug. PMID: 20690193.", + "2 Church Street South New Haven, CT 06519 Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Cardiovascular Data Science (CarDS) Lab", + "lab_url": "https://medicine.yale.edu/lab/cards/", + "research_bio": "INFORMATION FOR Copy Link In large national registries and datasets, we have defined both methodologic best practices for rigorous investigation and identified adherence to evidenced-based cardiovascular care A series of ongoing investigations focus on multimodality digital health data to evaluate the phenotypic variability of patients with cardiovascular disease and the quality of care they receive Our work focuses on a rigorous evaluation of health policies and their association with cardiovascular health and outcomes We have evaluated both the effectiveness and risk-stratification tools used to define the need for therapy in different populations Copy Link", + "publications_page": "https://medicine.yale.edu/lab/cards/publications/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Cardiovascular Medicine /", + "Lab Members", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Lab Members", + "Publications", + "News", + "", + "", + "", + "", + "", + "", + "AI, Health, and Health Care Today and Tomorrow: The JAMA Summit Report on Artificial Intelligence. Angus DC, Khera R, Lieu T, Liu V, Ahmad FS, Anderson B, Bhavani SV, Bindman A, Brennan T, Celi LA, Chen F, Cohen IG, Denniston A, Desai S, Embí P, Faisal A, Ferryman K, Gerhart J, Gross M, Hernandez-Boussard T, Howell M, Johnson K, Lee K, Liu X, Lomis K, London AJ, Longhurst CA, Mandl KD, McGlynn E, Mello MM, Munoz F, Ohno-Machado L, Ouyang D, Perlis R, Phillips A, Rhew D, Ross JS, Saria S, Schwamm L, Seymour CW, Shah NH, Shah R, Singh K, Solomon M, Spates K, Spector-Bagdady K, Wang T, Gichoya JW, Weinstein J, Wiens J, Bibbins-Domingo K. JAMA. 2025 Nov 11. PMID: 41082366.", + "Artificial Intelligence Across the JAMA Network: A Call for Submissions. Liu TYA, Hswen Y, Bonow RO, Carroll AE, Gross CP, Guterman EL, Khera R, Kibbe MR, Öngür D, Pirracchio R, Rotemberg V, Shew M, Shyr Y, Stuart EA, Bibbins-Domingo K, Perlis RH. JAMA. 2025 Nov 11. PMID: 41026475.", + "Phenotypic Selectivity of Artificial Intelligence-Enhanced Electrocardiography in Cardiovascular Diagnosis and Risk Prediction. Croon PM, Dhingra LS, Biswas D, Oikonomou EK, Khera R. Circulation. 2025 Nov 4; 2025 Sep 1. PMID: 40888124.", + "AI-Enabled Echocardiography Interpretation With Multitask Deep Learning-Reply. Holste G, Oikonomou EK, Khera R. JAMA. 2025 Oct 29; 2025 Oct 29. PMID: 41160035.", + "TARGET-AI: a foundational approach for the targeted deployment of artificial intelligence electrocardiography in the electronic health record. Oikonomou EK, Batinica B, Dhingra LS, Aminorroaya A, Coppi A, Khera R. medRxiv. 2025 Oct 25; 2025 Oct 25. PMID: 40909833.", + "Distributed Precision Stroke Care: Artificial Intelligence-Driven Stroke Management Using Multimodal Sensor Data. Pedroso AF, Schwamm LH, Khera R. Stroke. 2025 Oct 22; 2025 Oct 22. PMID: 41122835.", + "AI in Adipose Imaging: Revolutionizing Visceral Adipose Tissue, Ectopic Fat, and Cardiovascular Risk Assessment. Kandi SR, Khera R, Rajagopalan S, Neeland IJ. Curr Atheroscler Rep. 2025 Oct 9; 2025 Oct 9. PMID: 41068345.", + "National Patterns of Remote Patient Monitoring Service Availability at US Hospitals. Pedroso AF, Lin Z, Ross JS, Khera R. Circ Cardiovasc Qual Outcomes. 2025 Oct; 2025 Aug 19. PMID: 40827414.", + "Scientific Writing in the Era of Large Language Models: A Computational Analysis of AI- Versus Human-Created Content. Khera R, Pedroso AF, Keloth VK, Xu H, Silva GS, Schwamm LH. Stroke. 2025 Oct; 2025 Aug 15. PMID: 40814778.", + "Artificial intelligence-enabled electrocardiography and echocardiography to track preclinical progression of transthyretin amyloid cardiomyopathy. Oikonomou EK, Sangha V, Shankar SV, Coppi A, Krumholz HM, Nasir K, Miller EJ, Gallegos Kattan C, Al-Mallah MH, Al-Kindi S, Khera R. Eur Heart J. 2025 Oct 1. PMID: 40679604.", + "Artificial Intelligence in the Management of Heart Failure. Cheema B, Hourmozdi J, Kline A, Ahmad F, Khera R. J Card Fail. 2025 Oct; 2025 May 7. PMID: 40345521.", + "Evaluation of Care Quality for Atrial Fibrillation Across Non-Interoperable Electronic Health Record Data using a Retrieval-Augmented Generation-enabled Large Language Model. Adejumo P, Thangaraj PM, Dhingra LS, Biswas D, Aminorroaya A, Shankar SV, Pedroso AF, Croon PM, Khera R. medRxiv. 2025 Sep 24; 2025 Sep 24. PMID: 39371151.", + "Access to electrophysiologic care for Medicare beneficiaries across the United States: Travel distance and time to nearest clinician, 2013-2020. Khaloo P, Wheelock KM, Hanna J, Kapadia S, Pedroso AF, Nabi W, Aminorroaya A, Freeman JV, Khera R. Heart Rhythm. 2025 Sep 9; 2025 Sep 9. PMID: 40935055.", + "Transforming Population Health Screening for Atherosclerotic Cardiovascular Disease with AI-Enhanced ECG Analytics: Opportunities and Challenges. Biswas D, Aminorroaya A, Croon PM, Batinica B, Pedroso AF, Khera R. Curr Atheroscler Rep. 2025 Sep 1; 2025 Sep 1. PMID: 40888973.", + "Update to the JACC Report Card: Excess Cardiovascular Mortality Among Black Americans, 2000-2023. Arun AS, Sawano M, Lu Y, Warner F, Caraballo C, Khera R, Echols MR, Yancy CW, Krumholz HM. J Am Coll Cardiol. 2025 Aug 26; 2025 Jun 19. PMID: 40835364.", + "International Validation of Echocardiographic Artificial Intelligence Amyloid Detection Algorithm. Duffy G, Oikonomou EK, Easton N, Usuku H, Patel J, Katsumata Y, Yamasawa D, Stern L, Goto S, Tsujita K, Cheng P, Khera R, Ahmad FS, Ouyang D. JACC Adv. 2025 Aug 25; 2025 Aug 25. PMID: 40965401.", + "Phenotypic Selectivity of Artificial Intelligence-enhanced Electrocardiography in Cardiovascular Diagnosis and Risk Prediction. Croon PM, Dhingra LS, Biswas D, Oikonomou EK, Khera R. medRxiv. 2025 Aug 12; 2025 Aug 12. PMID: 40832396.", + "Artificial intelligence-enhanced echocardiography in cardiovascular disease management. Myhre PL, Grenne B, Asch FM, Delgado V, Khera R, Lafitte S, Lang RM, Pellikka PA, Sengupta PP, Vemulapalli S, Lam CSP. Nat Rev Cardiol. 2025 Aug 5; 2025 Aug 5. PMID: 40764834.", + "Changes in Cardiovascular Risk Factors and Health Care Expenditures Among Patients Prescribed Semaglutide. Lu Y, Liu Y, Totojani T, Kim C, Khera R, Xu H, Brush JE Jr, Krumholz HM, Abaluck J. JAMA Netw Open. 2025 Aug 1; 2025 Aug 1. PMID: 40779264.", + "Artificial intelligence-guided point-of-care ultrasonography for cardiomyopathy detection - Authors' reply. Oikonomou EK, Khera R. Lancet Digit Health. 2025 Aug; 2025 Aug 6. PMID: 40769793.", + "Identification of hypertrophic cardiomyopathy on electrocardiographic images with deep learning. Sangha V, Dhingra LS, Aminorroaya A, Croon PM, Sikand NV, Sen S, Martinez MW, Maron MS, Krumholz HM, Asselbergs FW, Oikonomou EK, Khera R. Nat Cardiovasc Res. 2025 Aug; 2025 Jul 22. PMID: 40696040.", + "Risk of Thyroid Tumors With GLP-1 Receptor Agonists: A Retrospective Cohort Study. Morales DR, Bu F, Viernes B, DuVall SL, Matheny ME, Simon KR, Falconer T, Richter LR, Ostropolets A, Lau WCY, Man KKC, Chattopadhyay S, Mathioudakis N, Minty E, Nishimura A, Sun F, Yin C, Seager SL, Chai Y, Zhou JJ, Lu Y, Reyes C, Pistillo A, Duarte-Salles T, Blacketer C, Schuemie MJ, Ryan PB, Krumholz HM, Hripcsak G, Khera R, Suchard MA. Diabetes Care. 2025 Aug 1. PMID: 40465422.", + "Nirmatrelvir-ritonavir versus placebo-ritonavir in individuals with long COVID in the USA (PAX LC): a double-blind, randomised, placebo-controlled, phase 2, decentralised trial. Sawano M, Bhattacharjee B, Caraballo C, Khera R, Li SX, Herrin J, Christian D, Coppi A, Warner F, Holub J, Henriquez Y, Johnson MA, Goddard TB, Rocco E, Hummel AC, Mouslmani MA, Hooper WB, Putrino DF, Carr KD, Charnas L, De Jesus M, Nepert D, Abreu P, Ziegler FW 3rd, Spertus JA, Iwasaki A, Krumholz HM. Lancet Infect Dis. 2025 Aug; 2025 Apr 3. PMID: 40188838.", + "Complete AI-Enabled Echocardiography Interpretation With Multitask Deep Learning. Holste G, Oikonomou EK, Tokodi M, Kovács A, Wang Z, Khera R. JAMA. 2025 Jul 22. PMID: 40549400.", + "Cardiac magnetic resonance markers of pre-clinical hypertrophic and dilated cardiomyopathy in genetic variant carriers. Croon PM, van Vugt M, Allaart CP, Ruijsink B, Elliott PM, Asselbergs FW, Khera R, Bezzina CR, Winter M, Schmidt AF. BMC Med. 2025 Jul 15; 2025 Jul 15. PMID: 40660250.", + "Development and multinational validation of an ensemble deep learning algorithm for detecting and predicting structural heart disease using noisy single-lead electrocardiograms. Aminorroaya A, Dhingra LS, Pedroso AF, Shankar SV, Coppi A, Khunte A, Foppa M, Brant LCC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. Eur Heart J Digit Health. 2025 Jul; 2025 Apr 10. PMID: 40703117.", + "Automated transformation of unstructured cardiovascular diagnostic reports into structured datasets using sequentially deployed large language models. Shankar SV, Dhingra LS, Aminorroaya A, Adejumo P, Nadkarni GN, Xu H, Brandt C, Oikonomou EK, Pedroso AF, Khera R. Eur Heart J Digit Health. 2025 Jul; 2025 Apr 2. PMID: 40703108.", + "Towards a dynamic model to estimate evolving risk of major bleeding after percutaneous coronary intervention. Hurley NC, Desai N, Dhruva SS, Khera R, Schulz W, Huang C, Curtis J, Masoudi F, Rumsfeld J, Negahban S, Krumholz HM, Mortazavi BJ. PLOS Digit Health. 2025 Jun; 2025 Jun 25. PMID: 40560847.", + "Wearable-Echo-FM: An ECG-echo foundation model for single lead electrocardiography. Knight E, Oikonomou EK, Aminorroaya A, Pedroso AF, Khera R. medRxiv. 2025 Jun 12; 2025 Jun 12. PMID: 40585148.", + "The emerging role of AI in transforming cardiovascular care. Croon PM, Pedroso AF, Khera R. Future Cardiol. 2025 Jun; 2025 Apr 18. PMID: 40248957.", + "Artificial Intelligence-Enabled Prediction of Heart Failure Risk From Single-Lead Electrocardiograms. Dhingra LS, Aminorroaya A, Pedroso AF, Khunte A, Sangha V, McIntyre D, Chow CK, Asselbergs FW, Brant LCC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. JAMA Cardiol. 2025 Jun 1. PMID: 40238120.", + "Controversy in Hypertension: Pro-Side of the Argument Using Artificial Intelligence for Hypertension Diagnosis and Management. Armoundas AA, Ahmad FS, Attia ZI, Doudesis D, Khera R, Kyriakoulis KG, Stergiou GS, Tang WHW. Hypertension. 2025 Jun; 2025 Mar 17. PMID: 40091745.", + "Internal Tremors and Vibrations in Long COVID: A Cross-Sectional Study. Zhou T, Sawano M, Arun AS, Caraballo C, Michelsen T, McAlpine LS, Bhattacharjee B, Lu Y, Khera R, Huang C, Warner F, Herrin J, Iwasaki A, Krumholz HM. Am J Med. 2025 Jun; 2024 Jul 26. PMID: 39069199.", + "A Real-world Evaluation of Longitudinal Healthcare Expenses in a Health System Registry of Type-2 Diabetes Mellitus and Cardiovascular Disease Enabled by the 21st Century Cures Act. Dhingra LS, Pedroso AF, Aminorroaya A, Rajpura J, Mehanna S, Tonnu-Mihara I, Khera R. medRxiv. 2025 May 29; 2025 May 29. PMID: 40492070.", + "Identification of Hypertrophic Cardiomyopathy on Electrocardiographic Images with Deep Learning. Sangha V, Dhingra LS, Aminorroaya A, Croon PM, Sikand NV, Sen S, Martinez MW, Maron MS, Krumholz HM, Asselbergs FW, Oikonomou EK, Khera R. medRxiv. 2025 May 28; 2025 May 28. PMID: 38234746.", + "National Patterns of Remote Patient Monitoring Service Availability at US Hospitals. Pedroso AF, Lin Z, Ross JS, Khera R. medRxiv. 2025 May 27; 2025 May 27. PMID: 39484237.", + "A Novel Sentence Transformer-based Natural Language Processing Approach for Schema Mapping of Electronic Health Records to the OMOP Common Data Model. Zhou X, Dhingra LS, Aminorroaya A, Adejumo P, Khera R. AMIA Annu Symp Proc. 2024; 2025 May 22. PMID: 40417570.", + "Effects of Tirzepatide in Type 2 Diabetes: Individual Variation and Relationship to Cardiometabolic Outcomes. Aminorroaya A, Oikonomou EK, Biswas D, Jastreboff AM, Khera R. J Am Coll Cardiol. 2025 May 20; 2025 Mar 30. PMID: 40368575.", + "Comparative Safety of Second-Line Antihyperglycemic Agents in Older Adults with Type 2 Diabetes: A Multinational Real-World Evidence From LEGEND-T2DM. Kim C, Bu F, Blacketer C, Ostropolets A, Duarte-Salles T, Viernes B, Falconer T, Pistillo A, Li J, Yin C, Van Zandt M, Nagy P, Nishimura A, Minty E, You SC, Sawano M, Sawano S, Jeon JY, Aminorroaya A, Dhingra LS, Pedroso AF, Thangraraj P, Dorr DA, Pratt N, Man KKC, Lau WCY, Morales DR, Khera R, Schuemie M, Ryan PB, Hripcsak G, Krumholz HM, Suchard MA, Lu Y. medRxiv. 2025 May 9; 2025 May 9. PMID: 40385382.", + "From Pixels to Patterns: Radiomic Subphenotyping of Left Ventricular Hypertrophy on Echocardiography. Oikonomou EK, Khera R. Circ Cardiovasc Imaging. 2025 May; 2025 May 6. PMID: 40326361.", + "Computational Phenomapping of Randomized Clinical Trial Participants to Enable Assessment of Their Real-World Representativeness and Personalized Inference. Thangaraj PM, Oikonomou EK, Dhingra LS, Aminorroaya A, Jayaram RH, Suchard MA, Khera R. Circ Cardiovasc Qual Outcomes. 2025 May; 2025 Apr 22. PMID: 40261065.", + "Assessment of health conditions from patient electronic health record portals vs self-reported questionnaires: an analysis of the INSPIRE study. Khera R, Sawano M, Warner F, Coppi A, Pedroso AF, Spatz ES, Yu H, Gottlieb M, Saydah S, Stephens KA, Rising KL, Elmore JG, Hill MJ, Idris AH, Montoy JCC, O'Laughlin KN, Weinstein RA, Venkatesh A. J Am Med Inform Assoc. 2025 May 1. PMID: 40036551.", + "The PAX LC Trial: A Decentralized, Phase 2, Randomized, Double-Blind Study of Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir for Long COVID. Krumholz HM, Sawano M, Bhattacharjee B, Caraballo C, Khera R, Li SX, Herrin J, Coppi A, Holub J, Henriquez Y, Johnson MA, Goddard TB, Rocco E, Hummel AC, Al Mouslmani M, Putrino DF, Carr KD, Carvajal-Gonzalez S, Charnas L, De Jesus M, Ziegler FW 3rd, Iwasaki A. Am J Med. 2025 May; 2024 May 10. PMID: 38735354.", + "Artificial Intelligence-Based Automated Interpretation of Images of Electrocardiograms: Development and Multinational Validation of ECG-GPT. Khunte A, Sangha V, Oikonomou EK, Dhingra LS, Aminorroaya A, Coppi A, Shankar SV, Rockers E, Mortazavi BJ, Bhatt DL, Krumholz HM, Al-Kindi S, Nadkarni GN, Vaid A, Khera R. medRxiv. 2025 Apr 22; 2025 Apr 22. PMID: 38405776.", + "PanEcho: Complete AI-enabled echocardiography interpretation with multi-task deep learning. Holste G, Oikonomou EK, Tokodi M, Kovács A, Wang Z, Khera R. medRxiv. 2025 Apr 16; 2025 Apr 16. PMID: 40321248.", + "Use of Artificial Intelligence Applied to Electrocardiogram for Diagnosis of Left Ventricular Systolic Dysfunction. Santana Júnior WB, Pinto Filho MM, Barreto SM, Foppa M, Giatti L, Khera R, Ribeiro ALP. Arq Bras Cardiol. 2025 Apr. PMID: 40396866.", + "Ensemble Deep Learning Algorithm for Structural Heart Disease Screening Using Electrocardiographic Images: PRESENT SHD. Dhingra LS, Aminorroaya A, Sangha V, Pedroso AF, Shankar SV, Coppi A, Foppa M, Brant LCC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. J Am Coll Cardiol. 2025 Apr 1. PMID: 40139886.", + "Artificial Intelligence to Enhance Precision Medicine in Cardio-Oncology: A Scientific Statement From the American Heart Association. Khera R, Asnani AH, Krive J, Addison D, Zhu H, Vasbinder A, Fleming MR, Arnaout R, Razavi P, Okwuosa TM. Circ Genom Precis Med. 2025 Apr; 2025 Feb 24. PMID: 39989357.", + "Predictors of Right Ventricular Pacing in Patients Undergoing Implantable Defibrillator Placement. Hummel JP, Lan Z, Jones PW, Khera R, Stein K, Curtis JP, Akar JG. J Cardiovasc Electrophysiol. 2025 Apr; 2025 Feb 10. PMID: 39930894.", + "Artificial intelligence-enabled echocardiography as a surrogate for multi-modality aortic stenosis imaging: post-hoc analysis of a clinical trial. Oikonomou EK, Craig NJ, Holste G, Shankar SV, White A, Mahendran M, Newby DE, Dweck MR, Khera R. medRxiv. 2025 Mar 27; 2025 Mar 27. PMID: 40196287.", + "Harnessing Artificial Intelligence for Innovation in Interventional Cardiovascular Care. Aminorroaya A, Biswas D, Pedroso AF, Khera R. J Soc Cardiovasc Angiogr Interv. 2025 Mar; 2025 Mar 18. PMID: 40230673.", + "Heart failure risk stratification using artificial intelligence applied to electrocardiogram images: a multinational study. Dhingra LS, Aminorroaya A, Sangha V, Pedroso AF, Asselbergs FW, Brant LCC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. Eur Heart J. 2025 Mar 13. PMID: 39804243.", + "Expanding artificial intelligence to understudied populations: congenital heart disease as the next frontier. Oikonomou EK, Khera R. Eur Heart J. 2025 Mar 3. PMID: 39523016.", + "Significance of Coronary Artery Calcifications and Ischemic Electrocardiographic Changes Among Patients Undergoing Myocardial Perfusion Imaging. Kokkinidis DG, Kyriakoulis I, Chui PW, Agarwal R, Liu YH, Khera R, Sinusas AJ, Velazquez EJ, Miller EJ, Feher A. JACC Adv. 2025 Mar; 2025 Feb 20. PMID: 39983619.", + "Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort study. Janetzki JL, Kim JH, Minty E, Lee JA, Morales DR, Khera R, Kim C, Alshammari TM, DuVall SL, Matheny ME, Falconer T, Kim S, Phan TP, Nguyen PA, Hsu MH, Hsu JC, Park RW, Man KKC, Seager S, Van Zandt M, Gilbert JP, Ryan PB, Schuemie MJ, Suchard MA, Hripcsak G, Pratt N, Chan You S. EClinicalMedicine. 2025 Mar; 2025 Feb 1. PMID: 39975698.", + "Tracking the Preclinical Progression of Transthyretin Amyloid Cardiomyopathy Using Artificial Intelligence-Enabled Electrocardiography and Echocardiography. Oikonomou EK, Sangha V, Vasisht Shankar S, Coppi A, Krumholz HM, Nasir K, Miller EJ, Gallegos-Kattan C, Al-Mallah MH, Al-Kindi S, Khera R. medRxiv. 2025 Feb 24; 2025 Feb 24. PMID: 39252891.", + "A Multicenter Evaluation of the Impact of Therapies on Deep Learning-Based Electrocardiographic Hypertrophic Cardiomyopathy Markers. Dhingra LS, Sangha V, Aminorroaya A, Bryde R, Gaballa A, Ali AH, Mehra N, Krumholz HM, Sen S, Kramer CM, Martinez MW, Desai MY, Oikonomou EK, Khera R. Am J Cardiol. 2025 Feb 15; 2024 Nov 23. PMID: 39581517.", + "Artificial intelligence-guided detection of under-recognised cardiomyopathies on point-of-care cardiac ultrasonography: a multicentre study. Oikonomou EK, Vaid A, Holste G, Coppi A, McNamara RL, Baloescu C, Krumholz HM, Wang Z, Apakama DJ, Nadkarni GN, Khera R. Lancet Digit Health. 2025 Feb. PMID: 39890242.", + "Evaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems. Aminorroaya A, Dhingra LS, Oikonomou EK, Khera R. Circ Genom Precis Med. 2025 Feb; 2025 Jan 23. PMID: 39846171.", + "Validating International Classification of Diseases Code 10th Revision algorithms for accurate identification of pulmonary embolism. Bikdeli B, Khairani CD, Bejjani A, Lo YC, Mahajan S, Caraballo C, Jimenez JV, Krishnathasan D, Zarghami M, Rashedi S, Jimenez D, Barco S, Secemsky EA, Klok FA, Hunsaker AR, Aghayev A, Muriel A, Hussain MA, Appah-Sampong A, Lu Y, Lin Z, Mojibian H, Aneja S, Khera R, Konstantinides S, Goldhaber SZ, Wang L, Zhou L, Monreal M, Piazza G, Krumholz HM. J Thromb Haemost. 2025 Feb; 2024 Nov 4. PMID: 39505153.", + "Computational Phenomapping of Randomized Clinical Trials to Enable Assessment of their Real-world Representativeness and Personalized Inference. Thangaraj PM, Oikonomou EK, Dhingra LS, Aminorroaya A, Jayaram R, Suchard MA, Khera R. medRxiv. 2025 Jan 24; 2025 Jan 24. PMID: 38798457.", + "Leveraging AI-enhanced digital health with consumer devices for scalable cardiovascular screening, prediction, and monitoring. Pedroso AF, Khera R. NPJ Cardiovasc Health. 2025; 2025 Jul 2. PMID: 40620667.", + "Automated Identification of Heart Failure With Reduced Ejection Fraction Using Deep Learning-Based Natural Language Processing. Nargesi AA, Adejumo P, Dhingra LS, Rosand B, Hengartner A, Coppi A, Benigeri S, Sen S, Ahmad T, Nadkarni GN, Lin Z, Ahmad FS, Krumholz HM, Khera R. JACC Heart Fail. 2025 Jan; 2024 Oct 23. PMID: 39453355.", + "Artificial Intelligence-Enhanced Risk Stratification of Cancer Therapeutics-Related Cardiac Dysfunction Using Electrocardiographic Images. Oikonomou EK, Sangha V, Dhingra LS, Aminorroaya A, Coppi A, Krumholz HM, Baldassarre LA, Khera R. Circ Cardiovasc Qual Outcomes. 2025 Jan; 2024 Sep 2. PMID: 39221857.", + "Designing medical artificial intelligence systems for global use: focus on interoperability, scalability, and accessibility. Oikonomou EK, Khera R. Hellenic J Cardiol. 2025 Jan-Feb; 2024 Jul 16. PMID: 39025234.", + "Transforming Hypertension Diagnosis and Management in The Era of Artificial Intelligence: A 2023 National Heart, Lung, and Blood Institute (NHLBI) Workshop Report. Shimbo D, Shah RU, Abdalla M, Agarwal R, Ahmad FS, Anaya G, Attia ZI, Bull S, Chang AR, Commodore-Mensah Y, Ferdinand K, Kawamoto K, Khera R, Leopold J, Luo J, Makhni S, Mortazavi BJ, Oh YS, Savage LC, Spatz ES, Stergiou G, Turakhia MP, Whelton PK, Yancy CW, Iturriaga E. Hypertension. 2025 Jan; 2024 Jul 16. PMID: 39011653.", + "An Ensemble Deep Learning Algorithm for Structural Heart Disease Screening Using Electrocardiographic Images: PRESENT SHD. Dhingra LS, Aminorroaya A, Sangha V, Pedroso AF, Shankar SV, Coppi A, Foppa M, Brant LC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. medRxiv. 2024 Dec 27; 2024 Dec 27. PMID: 39417095.", + "Artificial Intelligence Enabled Prediction of Heart Failure Risk from Single-lead Electrocardiograms. Dhingra LS, Aminorroaya A, Pedroso AF, Khunte A, Sangha V, McIntyre D, Chow CK, Asselbergs FW, Brant LC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. medRxiv. 2024 Dec 21; 2024 Dec 21. PMID: 38854022.", + "International Validation of Echocardiographic AI Amyloid Detection Algorithm. Duffy G, Oikonomou E, Hourmozdi J, Usuku H, Patel J, Stern L, Goto S, Tsujita K, Khera R, Ahmad FS, Ouyang D. medRxiv. 2024 Dec 16; 2024 Dec 16. PMID: 39763545.", + "Artificial Intelligence Applications for Electrocardiography to Define New Digital Biomarkers of Cardiovascular Risk. Sangha V, Khera R. Circ Cardiovasc Qual Outcomes. 2024 Dec; 2024 Nov 14. PMID: 39540286.", + "Cardiovascular care with digital twin technology in the era of generative artificial intelligence. Thangaraj PM, Benson SH, Oikonomou EK, Asselbergs FW, Khera R. Eur Heart J. 2024 Dec 1. PMID: 39322420.", + "Cardiac magnetic resonance markers of pre-clinical hypertrophic and dilated cardiomyopathy in genetic variant carriers. Croon PM, van Vugt M, Allaart CP, Ruijsink B, Elliott PM, Asselbergs FW, Khera R, Bezzina CR, Winter M, Schmidt AF. medRxiv. 2024 Nov 18; 2024 Nov 18. PMID: 39606349.", + "Impact of the COVID-19 pandemic on hospital-based heart failure care in New South Wales, Australia: a linked data cohort study. McIntyre D, Quintans D, Kazi S, Min H, He WQ, Marschner S, Khera R, Nassar N, Chow CK. BMC Health Serv Res. 2024 Nov 8; 2024 Nov 8. PMID: 39516863.", + "Natural Language Processing of Clinical Documentation to Assess Functional Status in Patients With Heart Failure. Adejumo P, Thangaraj PM, Dhingra LS, Aminorroaya A, Zhou X, Brandt C, Xu H, Krumholz HM, Khera R. JAMA Netw Open. 2024 Nov 4; 2024 Nov 4. PMID: 39509128.", + "Development and Multinational Validation of an Ensemble Deep Learning Algorithm for Detecting and Predicting Structural Heart Disease Using Noisy Single-lead Electrocardiograms. Aminorroaya A, Dhingra LS, Pedroso Camargos A, Vasisht Shankar S, Coppi A, Khunte A, Foppa M, Brant LC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. medRxiv. 2024 Oct 8; 2024 Oct 8. PMID: 39417103.", + "Automated Transformation of Unstructured Cardiovascular Diagnostic Reports into Structured Datasets Using Sequentially Deployed Large Language Models. Shankar SV, Dhingra LS, Aminorroaya A, Adejumo P, Nadkarni GN, Xu H, Brandt C, Oikonomou EK, Pedroso AF, Khera R. medRxiv. 2024 Oct 8; 2024 Oct 8. PMID: 39417094.", + "Racial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic. Faust JS, Renton B, Bongiovanni T, Chen AJ, Sheares KD, Du C, Essien UR, Fuentes-Afflick E, Haywood T, Khera R, King T, Li SX, Lin Z, Lu Y, Marshall ADA, Ndumele CD, Opara I, Loarte-Rodriguez T, Sawano M, Taparra K, Taylor HA, Watson KE, Yancy CW, Krumholz HM. JAMA Netw Open. 2024 Oct 1; 2024 Oct 1. PMID: 39392630.", + "Reviewer Experience Detecting and Judging Human Versus Artificial Intelligence Content: The Stroke Journal Essay Contest. Silva GS, Khera R, Schwamm LH. Stroke. 2024 Oct; 2024 Sep 3. PMID: 39224979.", + "Artificial intelligence-enhanced patient evaluation: bridging art and science. Oikonomou EK, Khera R. Eur Heart J. 2024 Sep 14. PMID: 38976371.", + "A Novel Digital Twin Strategy to Examine the Implications of Randomized Clinical Trials for Real-World Populations. Thangaraj PM, Shankar SV, Huang S, Nadkarni GN, Mortazavi BJ, Oikonomou EK, Khera R. medRxiv. 2024 Sep 6; 2024 Sep 6. PMID: 38585929.", + "Cause-Specific Mortality Rates Among the US Black Population. Arun AS, Caraballo C, Sawano M, Lu Y, Khera R, Yancy CW, Krumholz HM. JAMA Netw Open. 2024 Sep 3; 2024 Sep 3. PMID: 39348122.", + "Comparative Effectiveness of Second-Line Antihyperglycemic Agents for Cardiovascular Outcomes: A Multinational, Federated Analysis of LEGEND-T2DM. Khera R, Aminorroaya A, Dhingra LS, Thangaraj PM, Pedroso Camargos A, Bu F, Ding X, Nishimura A, Anand TV, Arshad F, Blacketer C, Chai Y, Chattopadhyay S, Cook M, Dorr DA, Duarte-Salles T, DuVall SL, Falconer T, French TE, Hanchrow EE, Kaur G, Lau WCY, Li J, Li K, Liu Y, Lu Y, Man KKC, Matheny ME, Mathioudakis N, McLeggon JA, McLemore MF, Minty E, Morales DR, Nagy P, Ostropolets A, Pistillo A, Phan TP, Pratt N, Reyes C, Richter L, Ross JS, Ruan E, Seager SL, Simon KR, Viernes B, Yang J, Yin C, You SC, Zhou JJ, Ryan PB, Schuemie MJ, Krumholz HM, Hripcsak G, Suchard MA. J Am Coll Cardiol. 2024 Sep 3. PMID: 39197980.", + "Correlation between hospital rates of survival to discharge and long-term survival for in-hospital cardiac arrest: Insights from Get With The Guidelines®-Resuscitation registry. Khera R, Aminorroaya A, Kennedy KF, Chan PS. Resuscitation. 2024 Sep; 2024 Jul 18. PMID: 39029583.", + "Local large language models for privacy-preserving accelerated review of historic echocardiogram reports. Vaid A, Duong SQ, Lampert J, Kovatch P, Freeman R, Argulian E, Croft L, Lerakis S, Goldman M, Khera R, Nadkarni GN. J Am Med Inform Assoc. 2024 Sep 1. PMID: 38687616.", + "Multimodal fusion learning for long QT syndrome pathogenic genotypes in a racially diverse population. Jiang J, Thi Vy HM, Charney A, Kovatch P, Reddy V, Jayaraman P, Do R, Khera R, Chugh S, Bhatt DL, Vaid A, Lampert J, Nadkarni GN. NPJ Digit Med. 2024 Aug 24; 2024 Aug 24. PMID: 39181999.", + "AI-enabled diagnosis from an electrocardiogram image: the next frontier of innovation in a century-old technology. Khera R. Heart. 2024 Aug 14; 2024 Aug 14. PMID: 39048290.", + "Excess Cardiovascular Mortality Among Black Americans 2000-2022. Arun AS, Sawano M, Lu Y, Warner F, Caraballo C, Khera R, Echols MR, Yancy CW, Krumholz HM. J Am Coll Cardiol. 2024 Aug 6; 2024 Jun 18. PMID: 38901531.", + "Video-Based Kinematic Analysis of Movement Quality in a Phase 3 Clinical Trial of Troriluzole in Adults with Spinocerebellar Ataxia: A Post Hoc Analysis. L'Italien GJ, Oikonomou EK, Khera R, Potashman MH, Beiner MW, Maclaine GDH, Schmahmann JD, Perlman S, Coric V. Neurol Ther. 2024 Aug; 2024 May 30. PMID: 38814532.", + "Efficient deep learning-based automated diagnosis from echocardiography with contrastive self-supervised learning. Holste G, Oikonomou EK, Mortazavi BJ, Wang Z, Khera R. Commun Med (Lond). 2024 Jul 6; 2024 Jul 6. PMID: 38971887.", + "Transforming Cardiovascular Care With Artificial Intelligence: From Discovery to Practice: JACC State-of-the-Art Review. Khera R, Oikonomou EK, Nadkarni GN, Morley JR, Wiens J, Butte AJ, Topol EJ. J Am Coll Cardiol. 2024 Jul 2. PMID: 38925729.", + "ECG Abnormality Detection Using MIMIC-IV-ECG Data Via Supervised Contrastive Learning. Nowroozilarki Z, Huang S, Khera R, Mortazavi BJ. Annu Int Conf IEEE Eng Med Biol Soc. 2024 Jul. PMID: 40039094.", + "Real-World Experience and Outcomes With Percutaneous Coronary Intervention for Protected Versus Unprotected Left Main Coronary Artery Disease: Insights from the Veteran Affairs Clinical Assessment Reporting and Tracking Program. Gonzalez PE, Hebbe A, Hussain Y, Khera R, Banerjee S, Plomondon ME, Waldo SW, Pfau SE, Curtis JP, Shah SM. Am J Cardiol. 2024 Jul 1; 2024 Apr 26. PMID: 38677666.", + "Leveraging the Full Potential of Wearable Devices in Cardiomyopathies. Oikonomou EK, Khera R. J Card Fail. 2024 Jul; 2024 Mar 5. PMID: 38452997.", + "Artificial intelligence-guided detection of under-recognized cardiomyopathies on point-of-care cardiac ultrasound: a multi-center study. Oikonomou EK, Vaid A, Holste G, Coppi A, McNamara RL, Baloescu C, Krumholz HM, Wang Z, Apakama DJ, Nadkarni GN, Khera R. medRxiv. 2024 Jun 29; 2024 Jun 29. PMID: 38559021.", + "Artificial Intelligence for Cardiovascular Care-Part 1: Advances: JACC Review Topic of the Week. Elias P, Jain SS, Poterucha T, Randazzo M, Lopez Jimenez F, Khera R, Perez M, Ouyang D, Pirruccello J, Salerno M, Einstein AJ, Avram R, Tison GH, Nadkarni G, Natarajan V, Pierson E, Beecy A, Kumaraiah D, Haggerty C, Avari Silva JN, Maddox TM. J Am Coll Cardiol. 2024 Jun 18; 2024 Apr 7. PMID: 38593946.", + "Artificial Intelligence in Cardiovascular Care-Part 2: Applications: JACC Review Topic of the Week. Jain SS, Elias P, Poterucha T, Randazzo M, Lopez Jimenez F, Khera R, Perez M, Ouyang D, Pirruccello J, Salerno M, Einstein AJ, Avram R, Tison GH, Nadkarni G, Natarajan V, Pierson E, Beecy A, Kumaraiah D, Haggerty C, Avari Silva JN, Maddox TM. J Am Coll Cardiol. 2024 Jun 18; 2024 Apr 7. PMID: 38593945.", + "Characteristics of High-Performing Hospitals in Cardiogenic Shock Following Acute Myocardial Infarction. Saha A, Li S, de Lemos JA, Pandey A, Bhatt DL, Fonarow GC, Nallamothu BK, Wang TY, Navar AM, Peterson E, Matsouaka RA, Bavry AA, Das SR, Grodin JL, Khera R, Drazner MH, Kumbhani DJ. Am J Cardiol. 2024 Jun 15; 2024 Apr 5. PMID: 38583700.", + "Performance of contemporary cardiovascular risk stratification scores in Brazil: an evaluation in the ELSA-Brasil study. Pedroso Camargos A, Barreto S, Brant L, Ribeiro ALP, Dhingra LS, Aminorroaya A, Bittencourt M, Figueiredo RC, Khera R. Open Heart. 2024 Jun 11; 2024 Jun 11. PMID: 38862252.", + "Study Protocol for the Artificial Intelligence-Driven Evaluation of Structural Heart Diseases Using Wearable Electrocardiogram (ID-SHD). Aminorroaya A, Dhingra LS, Camargos AP, Shankar SV, Khunte A, Sangha V, Sen S, McNamara RL, Haynes N, Oikonomou EK, Khera R. medRxiv. 2024 Jun 3; 2024 Jun 3. PMID: 38562867.", + "Data Interoperability for Ambulatory Monitoring of Cardiovascular Disease: A Scientific Statement From the American Heart Association. Armoundas AA, Ahmad FS, Bennett DA, Chung MK, Davis LL, Dunn J, Narayan SM, Slotwiner DJ, Wiley KK Jr, Khera R. Circ Genom Precis Med. 2024 Jun; 2024 May 23. PMID: 38779844.", + "Maps & Directions", + "1 Event you could attend in November 2025 Calendar", + "Contact Us", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Caroline Johnson Lab", + "lab_url": "https://medicine.yale.edu/lab/cjohnson/", + "research_bio": "INFORMATION FOR The Johnson Laboratory aims to develop a deeper understanding of sex-specific differences in metabolism that influence colorectal cancer etiology, progression, and response to therapeutics. In addition, our research integrates metabolomics analysis with studies on environmental exposures, birth cohorts, early-onset cancers, and microbiome, to understand biological responses to exposures in various contexts. Our lab has developed several analytical and bioinformatic protocols to enable a comprehensive analysis of the metabolome using high resolution mass spectrometry. Most recently we have optimized protocols for normalization of metabolites in various matrices from clinical samples, including dried blood spots and urine. Using computational tools and orthogonal biological techniques, we also investigate and manipulate metabolic pathways to gain insight into physiological responses. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/cjohnson/publications/", + "publications": [ + "Yale School of Public Health /", + "Projects The role of metabolites in colon cancer Identifying the biological effects of exposures", + "The role of metabolites in colon cancer", + "Identifying the biological effects of exposures", + "News", + "Metabolomic Capabilities", + "Publications", + "People", + "Prospective Students", + "Alumni", + "Donors", + "Employers", + "Academic Calendar", + "myYSPH Members", + "Support YSPH", + "Projects", + "Metabolomic Capabilities", + "Publications", + "People", + "News", + "", + "", + "", + "", + "", + "", + "Distinct metabolic and genetic alterations in tumors from early-onset versus late-onset colorectal cancer. Janak A, Jain A, Garcia-Milian R, Aladelokun O, Ma X, Paty PB, Khan SA, Johnson CH. Free Radic Biol Med. 2025 Dec 1; 2025 Aug 25. PMID: 40865779.", + "Quantitative Exposomics Targeting over 200 Toxicants and Key Biomarkers at the Picomolar Level. Gu Y, Feuerstein ML, Lloyd DT, Patel CJ, Johnson CH, Warth B. Environ Sci Technol. 2025 Oct 21; 2025 Oct 10. PMID: 41071047.", + "Psychosocial Risk Factors and Perceived Well-Being in Survivors of Gastrointestinal Cancer. Butensky SD, Schultz KS, Godfrey EL, Kim J, Sanft T, Johnson CH, Leeds IL, Khan SA. Psychooncology. 2025 Oct. PMID: 41068065.", + "Colorectal cancer molecular profiling: Opportunities for early detection. Sala A, van den Driest L, Rattray NJW, Johnson CH, Cameron JM, Khan SA, Palmer DS, Baker MJ. Clin Transl Med. 2025 Oct. PMID: 41020351.", + "Discovery of a Widespread Polyamine-Low-Molecular-Weight Thiol Hybrid Pathway in Clostridioides difficile. Hunt RL, Oh J, Jain A, Kuo TH, Berardi D, Jian W, Song D, Wu Q, Goodman AL, Palm NW, Zimmermann M, Johnson CH, Crawford JM. ACS Infect Dis. 2025 Aug 8; 2025 Jul 17. PMID: 40671632.", + "Senescence Cell Induction Methods Display Diverse Metabolic Reprogramming and Reveal an Underpinning Serine/Taurine Reductive Metabolic Phenotype. Berardi D, Farrell G, AlSultan A, McCulloch A, Hall NM, Sousa RPP, Jimenez M, Selman C, Bellantuono I, Johnson CH, Rattray Z, Rattray NJW. Aging Cell. 2025 Aug; 2025 Jun 18. PMID: 40530891.", + "Patient-Reported Barriers to Healthcare Access Among Patients with Gastrointestinal Cancer: Insights from 45,000 Participants in the All of Us Research Program. Butensky SD, Schultz KS, Godfrey EL, Kim J, Johnson CH, Leeds I, Khan SA. Res Sq. 2025 Jul 29; 2025 Jul 29. PMID: 40766231.", + "Mapping pesticide-induced metabolic alterations in human gut bacteria. Chen L, Yan H, Di S, Guo C, Zhang H, Zhang S, Gold A, Wang Y, Hu M, Wu D, Johnson CH, Wang X, Zhu J. Nat Commun. 2025 May 10; 2025 May 10. PMID: 40348778.", + "Sex-specific effects of exogenous asparagine on colorectal tumor growth, 17β-estradiol levels, and aromatase. Aladelokun O, Benitez K, Wang Y, Jain A, Berardi D, Maroun G, Shen X, Roper J, Gibson J, Sumigray K, Khan SA, Johnson CH. Pharmacol Res. 2025 May; 2025 Apr 12. PMID: 40228761.", + "Quality of gastrointestinal surgical oncology care according to insurance status. Butensky SD, Kerekes D, Bakkila BF, Billingsley KG, Ahuja N, Johnson CH, Khan SA. J Gastrointest Surg. 2025 Mar; 2025 Jan 10. PMID: 39800081.", + "Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway. Dudkina N, Park HB, Song D, Jain A, Khan SA, Flavell RA, Johnson CH, Palm NW, Crawford JM. Cell Chem Biol. 2025 Jan 16; 2024 Aug 19. PMID: 39163853.", + "OncoSexome: the landscape of sex-based differences in oncologic diseases. Shen X, Zhang Y, Li J, Zhou Y, Butensky SD, Zhang Y, Cai Z, DeWan AT, Khan SA, Yan H, Johnson CH, Zhu F. Nucleic Acids Res. 2025 Jan 6. PMID: 39535034.", + "Acetaminophen Use in Pregnancy: A Comparison of Self-Reported Intake with Maternal and Newborn Biomarker Measures. Guo P, Johnson CH, Yan H, Xiao J, Dennis C, Pierce KA, DeWan AT, Liew Z. Clin Epidemiol. 2025; 2025 Jan 3. PMID: 39781206.", + "Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer. Lu L, Zhang Q, Aladelokun O, Berardi D, Shen X, Marin A, Garcia-Milian R, Roper J, Khan SA, Johnson CH. Int J Cancer. 2025 Jan 1; 2024 Jul 22. PMID: 39039782.", + "Longitudinal biomonitoring of mycotoxin exposure during pregnancy in the Yale Pregnancy Outcome Prediction Study. Krausová M, Ayeni KI, Gu Y, Borutzki Y, O'Bryan J, Perley L, Silasi M, Wisgrill L, Johnson CH, Warth B. Environ Int. 2024 Dec; 2024 Oct 19. PMID: 39615253.", + "A gap analysis of UK biobank publications reveals SNPs associated with intrinsic subtypes of breast cancer. van den Driest L, Kelly P, Marshall A, Johnson CH, Lasky-Su J, Lannigan A, Rattray Z, Rattray NJW. Comput Struct Biotechnol J. 2024 Dec; 2024 May 10. PMID: 38817965.", + "Mapping Pesticide-Induced Metabolic Alterations in Human Gut Bacteria. Chen L, Yan H, Di S, Guo C, Zhang H, Zhang S, Gold A, Wang Y, Hu M, Wu D, Johnson CH, Wang X, Zhu J. bioRxiv. 2024 Nov 16; 2024 Nov 16. PMID: 39605636.", + "Charting the metabolic biogeography of the colorectum in cancer: challenging the right sided versus left sided classification. Jain A, Morris MT, Berardi D, Arora T, Domingo-Almenara X, Paty PB, Rattray NJW, Kerekes D, Lu L, Khan SA, Johnson CH. Mol Cancer. 2024 Sep 28; 2024 Sep 28. PMID: 39342363.", + "Transacylation and hydrolysis of the acyl glucuronides of ibuprofen and its α-methyl-substituted analogues investigated by (1)H NMR spectroscopy and computational chemistry: Implications for drug design. Richards SE, Bradshaw PR, Johnson CH, Stachulski AV, Athersuch TJ, Nicholson JK, Lindon JC, Wilson ID. J Pharm Biomed Anal. 2024 Aug 15; 2024 May 20. PMID: 38805849.", + "A machine learning and drug repurposing approach to target ferroptosis in colorectal cancer stratified by sex and KRAS. Yan H, Shen X, Yao Y, Khan SA, Ma S, Johnson CH. bioRxiv. 2024 Jun 28; 2024 Jun 28. PMID: 38979294.", + "Growth characteristics of HCT116 xenografts lacking asparagine synthetase vary according to sex. Aladelokun O, Lu L, Zheng J, Yan H, Jain A, Gibson J, Khan SA, Johnson CH. Hum Genomics. 2024 Jun 17; 2024 Jun 17. PMID: 38886847.", + "Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids. Zheng J, Sun B, Berardi D, Lu L, Yan H, Zheng S, Aladelokun O, Xie Y, Cai Y, Godri Pollitt KJ, Khan SA, Johnson CH. Environ Sci Technol. 2023 Dec 19; 2023 Dec 8. PMID: 38064429.", + "Multi-omic analysis reveals metabolic pathways that characterize right-sided colon cancer liver metastasis. Morris MT, Jain A, Sun B, Kurbatov V, Muca E, Zeng Z, Jin Y, Roper J, Lu J, Paty PB, Johnson CH, Khan SA. Cancer Lett. 2023 Oct 10; 2023 Sep 14. PMID: 37716465.", + "Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study. Rosen Vollmar AK, Lin EZ, Nason SL, Santiago K, Johnson CH, Ma X, Godri Pollitt KJ, Deziel NC. J Expo Sci Environ Epidemiol. 2023 Sep; 2023 Sep 20. PMID: 37730931.", + "Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study. Rosen Vollmar AK, Rattray NJW, Cai Y, Jain A, Yan H, Deziel NC, Calafat AM, Wilcox AJ, Jukic AMZ, Johnson CH. Environ Health Perspect. 2023 Sep; 2023 Sep 13. PMID: 37702489.", + "Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations. Yan H, Talty R, Jain A, Cai Y, Zheng J, Shen X, Muca E, Paty PB, Bosenberg MW, Khan SA, Johnson CH. Redox Biol. 2023 Jun; 2023 Apr 14. PMID: 37086630.", + "Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer. Lu L, Zhang Q, Shen X, Zhen P, Marin A, Garcia-Milian R, Roper J, Khan SA, Johnson CH. bioRxiv. 2023 May 5; 2023 May 5. PMID: 37205388.", + "Hepatopancreatobiliary malignancies: time to treatment matters. Kerekes DM, Frey AE, Bakkila BF, Johnson CH, Becher RD, Billingsley KG, Khan SA. J Gastrointest Oncol. 2023 Apr 29; 2023 Apr 17. PMID: 37201090.", + "Ferroptosis in colorectal cancer: a future target? Yan H, Talty R, Aladelokun O, Bosenberg M, Johnson CH. Br J Cancer. 2023 Apr; 2023 Jan 26. PMID: 36703079.", + "In silico designed mRNA vaccines targeting CA-125 neoantigen in breast and ovarian cancer. Lu L, Ma W, Johnson CH, Khan SA, Irwin ML, Pusztai L. Vaccine. 2023 Mar 17; 2023 Feb 20. PMID: 36813666.", + "Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations. Yan H, Talty R, Jain A, Cai Y, Zheng J, Shen X, Muca E, Paty PB, Bosenberg MW, Khan SA, Johnson CH. bioRxiv. 2023 Mar 1; 2023 Mar 1. PMID: 36909561.", + "Early-Onset Colorectal Cancer Somatic Gene Mutations by Population Subgroups. Shen X, DeWan AT, Johnson CH. Cancer Discov. 2023 Mar 1. PMID: 36855917.", + "Targeting ferroptosis to treat colorectal cancer. Yan H, Talty R, Johnson CH. Trends Cell Biol. 2023 Mar; 2022 Dec 3. PMID: 36473802.", + "Prenatal Choline Supplement in a Maternal Obesity Model Modulates Offspring Hepatic Lipidomes. Korsmo HW, Kadam I, Reaz A, Bretter R, Saxena A, Johnson CH, Caviglia JM, Jiang X. Nutrients. 2023 Feb 15; 2023 Feb 15. PMID: 36839327.", + "Urinary phenol concentrations and fecundability and early pregnancy loss. Rosen Vollmar AK, Weinberg CR, Baird DD, Wilcox AJ, Calafat AM, Deziel NC, Johnson CH, Jukic AMZ. Hum Reprod. 2023 Jan 5. PMID: 36346334.", + "Hemoglobin normalization outperforms other methods for standardizing dried blood spot metabolomics: A comparative study. Jain A, Morris M, Lin EZ, Khan SA, Ma X, Deziel NC, Godri Pollitt KJ, Johnson CH. Sci Total Environ. 2023 Jan 1; 2022 Sep 13. PMID: 36113793.", + "Bile acid distributions, sex-specificity, and prognosis in colorectal cancer. Cai Y, Shen X, Lu L, Yan H, Huang H, Gaule P, Muca E, Theriot CM, Rattray Z, Rattray NJW, Lu J, Ahuja N, Zhang Y, Paty PB, Khan SA, Johnson CH. Biol Sex Differ. 2022 Oct 23; 2022 Oct 23. PMID: 36274154.", + "Asparagine, colorectal cancer, and the role of sex, genes, microbes, and diet: A narrative review. Shen X, Jain A, Aladelokun O, Yan H, Gilbride A, Ferrucci LM, Lu L, Khan SA, Johnson CH. Front Mol Biosci. 2022; 2022 Aug 25. PMID: 36090030.", + "Evaluation of the role of KPNA2 mutations in breast cancer prognosis using bioinformatics datasets. Alnoumas L, van den Driest L, Apczynski Z, Lannigan A, Johnson CH, Rattray NJW, Rattray Z. BMC Cancer. 2022 Aug 10; 2022 Aug 10. PMID: 35948941.", + "TidyMass an object-oriented reproducible analysis framework for LC-MS data. Shen X, Yan H, Wang C, Gao P, Johnson CH, Snyder MP. Nat Commun. 2022 Jul 28; 2022 Jul 28. PMID: 35902589.", + "Development of an Accessible Gene Expression Bioinformatics Pipeline to Study Driver Mutations of Colorectal Cancer. van den Driest L, Johnson CH, Rattray NJW, Rattray Z. Altern Lab Anim. 2022 Jul; 2022 Jun 28. PMID: 35765262.", + "Evaluation of Racial Disparities in Quality of Care for Patients With Gastrointestinal Tract Cancer Treated With Surgery. Bakkila BF, Kerekes D, Nunez-Smith M, Billingsley KG, Ahuja N, Wang K, Oladele C, Johnson CH, Khan SA. JAMA Netw Open. 2022 Apr 1; 2022 Apr 1. PMID: 35377425.", + "Non-targeted metabolomics and associations with per- and polyfluoroalkyl substances (PFAS) exposure in humans: A scoping review. Guo P, Furnary T, Vasiliou V, Yan Q, Nyhan K, Jones DP, Johnson CH, Liew Z. Environ Int. 2022 Apr; 2022 Feb 26. PMID: 35231839.", + "Asparagine Metabolism in Tumors Is Linked to Poor Survival in Females with Colorectal Cancer: A Cohort Study. Shen X, Cai Y, Lu L, Huang H, Yan H, Paty PB, Muca E, Ahuja N, Zhang Y, Johnson CH, Khan SA. Metabolites. 2022 Feb 9; 2022 Feb 9. PMID: 35208238.", + "Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach. Charkoftaki G, Golla JP, Santos-Neto A, Orlicky DJ, Garcia-Milian R, Chen Y, Rattray NJW, Cai Y, Wang Y, Shearn CT, Mironova V, Wang Y, Johnson CH, Thompson DC, Vasiliou V. Toxicol Sci. 2021 Sep 28. PMID: 33693819.", + "Molecular Mechanisms of Alcohol-Induced Colorectal Carcinogenesis. Johnson CH, Golla JP, Dioletis E, Singh S, Ishii M, Charkoftaki G, Thompson DC, Vasiliou V. Cancers (Basel). 2021 Aug 31; 2021 Aug 31. PMID: 34503214.", + "ENT2 facilitates brain endothelial cell penetration and blood-brain barrier transport by a tumor-targeting anti-DNA autoantibody. Rattray Z, Deng G, Zhang S, Shirali A, May CK, Chen X, Cuffari BJ, Liu J, Zou P, Rattray NJ, Johnson CH, Dubljevic V, Campbell JA, Huttner A, Baehring JM, Zhou J, Hansen JE. JCI Insight. 2021 Jul 22; 2021 Jul 22. PMID: 34128837.", + "Kynurenic acid may underlie sex-specific immune responses to COVID-19. Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Yan H, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh JE, Silva J, Wong P, Ko AI, Khan SA, Iwasaki A, Johnson CH. Sci Signal. 2021 Jul 6; 2021 Jul 6. PMID: 34230210.", + "Intratumour microbiome associated with the infiltration of cytotoxic CD8+ T cells and patient survival in cutaneous melanoma. Zhu G, Su H, Johnson CH, Khan SA, Kluger H, Lu L. Eur J Cancer. 2021 Jul; 2021 May 4. PMID: 33962358.", + "YIV-906 potentiated anti-PD1 action against hepatocellular carcinoma by enhancing adaptive and innate immunity in the tumor microenvironment. Yang X, Lam W, Jiang Z, Guan F, Han X, Hu R, Cai W, Cheng W, Liu SH, Cheng P, Cai Y, Rattray NJW, Johnson CH, Chen L, Cheng YC. Sci Rep. 2021 Jun 29; 2021 Jun 29. PMID: 34188068.", + "Use of Untargeted Metabolomics to Explore the Air Pollution-Related Disease Continuum. Jin L, Godri Pollitt KJ, Liew Z, Rosen Vollmar AK, Vasiliou V, Johnson CH, Zhang Y. Curr Environ Health Rep. 2021 Mar; 2021 Jan 9. PMID: 33420964.", + "Accounting for urinary dilution in peri-implantation samples: implications for creatinine adjustment and specimen pooling. Rosen Vollmar AK, Johnson CH, Weinberg CR, Deziel NC, Baird DD, Wilcox AJ, Jukic AMZ. J Expo Sci Environ Epidemiol. 2021 Mar; 2020 May 18. PMID: 32424331.", + "Immune landscape and prognostic immune-related genes in KRAS-mutant colorectal cancer patients. Liu J, Huang X, Liu H, Wei C, Ru H, Qin H, Lai H, Meng Y, Wu G, Xie W, Mo X, Johnson CH, Zhang Y, Tang W. J Transl Med. 2021 Jan 7; 2021 Jan 7. PMID: 33413474.", + "Gene Alterations of N6-Methyladenosine (m(6)A) Regulators in Colorectal Cancer: A TCGA Database Study. Zhang Q, Cai Y, Kurbatov V, Khan SA, Lu L, Zhang Y, Johnson CH. Biomed Res Int. 2020; 2020 Dec 19. PMID: 33415160.", + "Kynurenic acid underlies sex-specific immune responses to COVID-19. Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh J, Silva J, Wong P, Ko AI, Khan SA, Iwasaki A, Johnson CH. medRxiv. 2020 Sep 8; 2020 Sep 8. PMID: 32935119.", + "Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage. Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Muca E, Vollmar AKR, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Metabolites. 2020 Jun 19; 2020 Jun 19. PMID: 32575361.", + "Joint effect of pre-operative anemia and perioperative blood transfusion on outcomes of colon-cancer patients undergoing colectomy. Liu Z, Luo JJ, Pei KY, Khan SA, Wang XX, Zhao ZX, Yang M, Johnson CH, Wang XS, Zhang Y. Gastroenterol Rep (Oxf). 2020 Apr; 2019 Aug 9. PMID: 32280475.", + "Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype. Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Sci Rep. 2020 Mar 17; 2020 Mar 17. PMID: 32184446.", + "Analyzing Metabolomics Data for Environmental Health and Exposome Research. Cai Y, Rosen Vollmar AK, Johnson CH. Methods Mol Biol. 2020. PMID: 31953830.", + "Molecular Pathway Analysis Indicates a Distinct Metabolic Phenotype in Women With Right-Sided Colon Cancer. Sun Y, Mironova V, Chen Y, Lundh EPF, Zhang Q, Cai Y, Vasiliou V, Zhang Y, Garcia-Milian R, Khan SA, Johnson CH. Transl Oncol. 2020 Jan; 2019 Nov 21. PMID: 31760268.", + "1,4-Dioxane as an emerging water contaminant: State of the science and evaluation of research needs. Godri Pollitt KJ, Kim JH, Peccia J, Elimelech M, Zhang Y, Charkoftaki G, Hodges B, Zucker I, Huang H, Deziel NC, Murphy K, Ishii M, Johnson CH, Boissevain A, O'Keefe E, Anastas PT, Orlicky D, Thompson DC, Vasiliou V. Sci Total Environ. 2019 Nov 10; 2019 Jun 28. PMID: 31302550.", + "Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty. Rattray NJW, Trivedi DK, Xu Y, Chandola T, Johnson CH, Marshall AD, Mekli K, Rattray Z, Tampubolon G, Vanhoutte B, White IR, Wu FCW, Pendleton N, Nazroo J, Goodacre R. Nat Commun. 2019 Nov 5; 2019 Nov 5. PMID: 31690722.", + "Normalizing Untargeted Periconceptional Urinary Metabolomics Data: A Comparison of Approaches. Rosen Vollmar AK, Rattray NJW, Cai Y, Santos-Neto ÁJ, Deziel NC, Jukic AMZ, Johnson CH. Metabolites. 2019 Sep 21; 2019 Sep 21. PMID: 31546636.", + "Evaluation of potential carcinogenicity of organic chemicals in synthetic turf crumb rubber. Perkins AN, Inayat-Hussain SH, Deziel NC, Johnson CH, Ferguson SS, Garcia-Milian R, Thompson DC, Vasiliou V. Environ Res. 2019 Feb; 2018 Oct 24. PMID: 30458352.", + "Palbociclib and Fulvestrant Act in Synergy to Modulate Central Carbon Metabolism in Breast Cancer Cells. Warth B, Palermo A, Rattray NJW, Lee NV, Zhu Z, Hoang LT, Cai Y, Mazurek A, Dann S, VanArsdale T, Fantin VR, Shields D, Siuzdak G, Johnson CH. Metabolites. 2019 Jan 2; 2019 Jan 2. PMID: 30609717.", + "Defining Early-Onset Colon and Rectal Cancers. Jacobs D, Zhu R, Luo J, Grisotti G, Heller DR, Kurbatov V, Johnson CH, Zhang Y, Khan SA. Front Oncol. 2018; 2018 Nov 6. PMID: 30460196.", + "Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ. Redox Biol. 2018 Jul; 2018 Apr 13. PMID: 29747066.", + "Distinctive features of gastrointestinal stromal tumors arising from the colon and rectum. Zhu R, Liu F, Grisotti G, Pérez-Irizarry J, Cha CH, Johnson CH, Boffa DJ, Han D, Johung KL, Zhang Y, Khan SA. J Gastrointest Oncol. 2018 Apr. PMID: 29755761.", + "Metabolomics Reveals that Dietary Xenoestrogens Alter Cellular Metabolism Induced by Palbociclib/Letrozole Combination Cancer Therapy. Warth B, Raffeiner P, Granados A, Huan T, Fang M, Forsberg EM, Benton HP, Goetz L, Johnson CH, Siuzdak G. Cell Chem Biol. 2018 Mar 15; 2018 Jan 11. PMID: 29337187.", + "Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming. Wang Y, Chen Y, Guan L, Zhang H, Huang Y, Johnson CH, Wu Z, Gonzalez FJ, Yu A, Huang P, Wang Y, Yang S, Chen P, Fan X, Huang M, Bi H. Cell Death Differ. 2018 Mar; 2018 Jan 9. PMID: 29317762.", + "Yale School of Public Health Symposium on tissue imaging mass spectrometry: illuminating phenotypic heterogeneity and drug disposition at the molecular level. Charkoftaki G, Rattray NJW, Andrén PE, Caprioli RM, Castellino S, Duncan MW, Goodwin RJA, Schey KL, Shahidi-Latham SK, Veselkov KA, Johnson CH, Vasiliou V. Hum Genomics. 2018 Feb 27; 2018 Feb 27. PMID: 29482659.", + "Re-engineering and evaluation of anti-DNA autoantibody 3E10 for therapeutic applications. Rattray Z, Dubljevic V, Rattray NJW, Greenwood DL, Johnson CH, Campbell JA, Hansen JE. Biochem Biophys Res Commun. 2018 Feb 12; 2018 Jan 31. PMID: 29374508.", + "Beyond genomics: understanding exposotypes through metabolomics. Rattray NJW, Deziel NC, Wallach JD, Khan SA, Vasiliou V, Ioannidis JPA, Johnson CH. Hum Genomics. 2018 Jan 26; 2018 Jan 26. PMID: 29373992.", + "Yale school of public health symposium on lifetime exposures and human health: the exposome; summary and future reflections. Johnson CH, Athersuch TJ, Collman GW, Dhungana S, Grant DF, Jones DP, Patel CJ, Vasiliou V. Hum Genomics. 2017 Dec 8; 2017 Dec 8. PMID: 29221465.", + "Exposome-Scale Investigations Guided by Global Metabolomics, Pathway Analysis, and Cognitive Computing. Warth B, Spangler S, Fang M, Johnson CH, Forsberg EM, Granados A, Martin RL, Domingo-Almenara X, Huan T, Rinehart D, Montenegro-Burke JR, Hilmers B, Aisporna A, Hoang LT, Uritboonthai W, Benton HP, Richardson SD, Williams AJ, Siuzdak G. Anal Chem. 2017 Nov 7; 2017 Oct 9. PMID: 28945073.", + "Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids. Johnson CH, Santidrian AF, LeBoeuf SE, Kurczy ME, Rattray NJW, Rattray Z, Warth B, Ritland M, Hoang LT, Loriot C, Higa J, Hansen JE, Felding BH, Siuzdak G. Cancer Metab. 2017; 2017 Oct 31. PMID: 29093815.", + "Environmental influences in the etiology of colorectal cancer: the premise of metabolomics. Rattray NJW, Charkoftaki G, Rattray Z, Hansen JE, Vasiliou V, Johnson CH. Curr Pharmacol Rep. 2017 Jun; 2017 Apr 7. PMID: 28642837.", + "Systems biology guided by XCMS Online metabolomics. Huan T, Forsberg EM, Rinehart D, Johnson CH, Ivanisevic J, Benton HP, Fang M, Aisporna A, Hilmers B, Poole FL, Thorgersen MP, Adams MWW, Krantz G, Fields MW, Robbins PD, Niedernhofer LJ, Ideker T, Majumder EL, Wall JD, Rattray NJW, Goodacre R, Lairson LL, Siuzdak G. Nat Methods. 2017 Apr 27. PMID: 28448069.", + "PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C. Chen Y, Wang Y, Huang Y, Zeng H, Hu B, Guan L, Zhang H, Yu AM, Johnson CH, Gonzalez FJ, Huang M, Bi H. Carcinogenesis. 2017 Apr 1. PMID: 28334197.", + "Metabolite and Microbiome Interplay in Cancer Immunotherapy. Johnson CH, Spilker ME, Goetz L, Peterson SN, Siuzdak G. Cancer Res. 2016 Nov 1; 2016 Oct 11. PMID: 27729325.", + "Metabolomics: beyond biomarkers and towards mechanisms. Johnson CH, Ivanisevic J, Siuzdak G. Nat Rev Mol Cell Biol. 2016 Jul; 2016 Mar 16. PMID: 26979502.", + "Metabolomics reveals mycoplasma contamination interferes with the metabolism of PANC-1 cells. Yu T, Wang Y, Zhang H, Johnson CH, Jiang Y, Li X, Wu Z, Liu T, Krausz KW, Yu A, Gonzalez FJ, Huang M, Bi H. Anal Bioanal Chem. 2016 Jun; 2016 Apr 13. PMID: 27074779.", + "Global metabolomics reveals metabolic dysregulation in ischemic retinopathy. Paris LP, Johnson CH, Aguilar E, Usui Y, Cho K, Hoang LT, Feitelberg D, Benton HP, Westenskow PD, Kurihara T, Trombley J, Tsubota K, Ueda S, Wakabayashi Y, Patti GJ, Ivanisevic J, Siuzdak G, Friedlander M. Metabolomics. 2016; 2015 Nov 18. PMID: 26617478.", + "Determining conserved metabolic biomarkers from a million database queries. Kurczy ME, Ivanisevic J, Johnson CH, Uritboonthai W, Hoang L, Fang M, Hicks M, Aldebot A, Rinehart D, Mellander LJ, Tautenhahn R, Patti GJ, Spilker ME, Benton HP, Siuzdak G. Bioinformatics. 2015 Dec 1; 2015 Aug 13. PMID: 26275895.", + "Thermal Degradation of Small Molecules: A Global Metabolomic Investigation. Fang M, Ivanisevic J, Benton HP, Johnson CH, Patti GJ, Hoang LT, Uritboonthai W, Kurczy ME, Siuzdak G. Anal Chem. 2015 Nov 3; 2015 Oct 14. PMID: 26434689.", + "Alterations in Spinal Cord Metabolism during Treatment of Neuropathic Pain. Johnson CH, Patti GJ, Courade JP, Shriver LP, Hoang LT, Manchester M, Siuzdak G. J Neuroimmune Pharmacol. 2015 Sep; 2015 Aug 2. PMID: 26232265.", + "Arteriovenous Blood Metabolomics: A Readout of Intra-Tissue Metabostasis. Ivanisevic J, Elias D, Deguchi H, Averell PM, Kurczy M, Johnson CH, Tautenhahn R, Zhu Z, Watrous J, Jain M, Griffin J, Patti GJ, Siuzdak G. Sci Rep. 2015 Aug 5; 2015 Aug 5. PMID: 26244428.", + "Metabolism links bacterial biofilms and colon carcinogenesis. Johnson CH, Dejea CM, Edler D, Hoang LT, Santidrian AF, Felding BH, Ivanisevic J, Cho K, Wick EC, Hechenbleikner EM, Uritboonthai W, Goetz L, Casero RA Jr, Pardoll DM, White JR, Patti GJ, Sears CL, Siuzdak G. Cell Metab. 2015 Jun 2; 2015 May 7. PMID: 25959674.", + "Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids. Kurczy ME, Zhu ZJ, Ivanisevic J, Schuyler AM, Lalwani K, Santidrian AF, David JM, Giddabasappa A, Roberts AJ, Olivos HJ, O'Brien PJ, Franco L, Fields MW, Paris LP, Friedlander M, Johnson CH, Epstein AA, Gendelman HE, Wood MR, Felding BH, Patti GJ, Spilker ME, Siuzdak G. Nat Commun. 2015 Jan 20; 2015 Jan 20. PMID: 25601659.", + "Autonomous metabolomics for rapid metabolite identification in global profiling. Benton HP, Ivanisevic J, Mahieu NG, Kurczy ME, Johnson CH, Franco L, Rinehart D, Valentine E, Gowda H, Ubhi BK, Tautenhahn R, Gieschen A, Fields MW, Patti GJ, Siuzdak G. Anal Chem. 2015 Jan 20; 2014 Dec 26. PMID: 25496351.", + "Bioinformatics: the next frontier of metabolomics. Johnson CH, Ivanisevic J, Benton HP, Siuzdak G. Anal Chem. 2015 Jan 6; 2014 Nov 20. PMID: 25389922.", + "N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis. Bi HC, Pan YZ, Qiu JX, Krausz KW, Li F, Johnson CH, Jiang CT, Gonzalez FJ, Yu AM. Carcinogenesis. 2014 Oct; 2014 Aug 12. PMID: 25115443.", + "Interactive XCMS Online: simplifying advanced metabolomic data processing and subsequent statistical analyses. Gowda H, Ivanisevic J, Johnson CH, Kurczy ME, Benton HP, Rinehart D, Nguyen T, Ray J, Kuehl J, Arevalo B, Westenskow PD, Wang J, Arkin AP, Deutschbauer AM, Patti GJ, Siuzdak G. Anal Chem. 2014 Jul 15; 2014 Jun 25. PMID: 24934772.", + "Metabolomic data streaming for biology-dependent data acquisition. Rinehart D, Johnson CH, Nguyen T, Ivanisevic J, Benton HP, Lloyd J, Arkin AP, Deutschbauer AM, Patti GJ, Siuzdak G. Nat Biotechnol. 2014 Jun. PMID: 24911492.", + "Luciferase does not Alter Metabolism in Cancer Cells. Johnson CH, Fisher TS, Hoang LT, Felding BH, Siuzdak G, O'Brien PJ. Metabolomics. 2014 Jun 1. PMID: 24791164.", + "Global metabolomics reveals urinary biomarkers of breast cancer in a mcf-7 xenograft mouse model. Johnson CH, Manna SK, Krausz KW, Bonzo JA, Divelbiss RD, Hollingshead MG, Gonzalez FJ. Metabolites. 2013 Aug 7; 2013 Aug 7. PMID: 24958144.", + "Toward 'omic scale metabolite profiling: a dual separation-mass spectrometry approach for coverage of lipid and central carbon metabolism. Ivanisevic J, Zhu ZJ, Plate L, Tautenhahn R, Chen S, O'Brien PJ, Johnson CH, Marletta MA, Patti GJ, Siuzdak G. Anal Chem. 2013 Jul 16; 2013 Jul 3. PMID: 23781873.", + "Optimization of harvesting, extraction, and analytical protocols for UPLC-ESI-MS-based metabolomic analysis of adherent mammalian cancer cells. Bi H, Krausz KW, Manna SK, Li F, Johnson CH, Gonzalez FJ. Anal Bioanal Chem. 2013 Jun; 2013 Apr 19. PMID: 23604415.", + "Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database. Zhu ZJ, Schultz AW, Wang J, Johnson CH, Yannone SM, Patti GJ, Siuzdak G. Nat Protoc. 2013 Mar; 2013 Feb 7. PMID: 23391889.", + "Cytochrome P450 regulation by α-tocopherol in Pxr-null and PXR-humanized mice. Johnson CH, Bonzo JA, Cheng J, Krausz KW, Kang DW, Luecke H, Idle JR, Gonzalez FJ. Drug Metab Dispos. 2013 Feb; 2012 Nov 16. PMID: 23160821.", + "Calendar", + "PO Box 208034 New Haven, CT 06520", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Chandra Lab", + "lab_url": "https://medicine.yale.edu/lab/chandra/", + "research_bio": "INFORMATION FOR Copy Link The Chandra lab explores two related themes: synaptic biology and neurodegeneration. Synapses (connections between neurons) need to be maintained throughout the life of an organism to provide for normal brain function and behaviors. In the healthy brain, the majority of synapses are largely stable throughout life. However, in late-onset neurodegenerative disorders, synaptic dysfunction and synapse loss are early, pivotal events. In these devastating diseases, synaptic changes occur in the prodromal stage of disease, prior to neuronal cell death. Thus, elucidating the mechanisms by which synapses are maintained is of high biomedical importance. This is the focus of our research. My laboratory studies how synapses are normally maintained and how disruption in these processes results in neurodegenerative disorders. Recent work - including from my group - has shown that local synaptic protein homeostasis (proteostasis) mechanisms are essential for maintaining the structure and functionality of synapses. Emerging genetic data strongly support the tenet that synaptic proteostasis is disrupted in late-onset neurodegenerative diseases. My group currently investigates two related neurodegenerative diseases, namely Parkinson’s disease (PD) and neuronal ceroid lipofuscinosis (NCL). Our central hypothesis is that PD and NCL are diseases of the synapse, particularly diseases of presynaptic proteostasis and dysfunction. The findings that a-synuclein, a key protein in the pathophysiology of PD, oligomerizes/aggregates at the presynaptic terminal and the three known presynaptic co-chaperones, CSPa, auxilin, and RME-8 are mutated in NCL and PD, respectively, strongly support our hypothesis. Furthermore, our current progress on investigating a-synuclein, synaptic chaperones, as well as degradative pathways is in line with this hypothesis. To elucidate synapse maintenance mechanisms and understand the early, synaptic events of PD and NCL, we use mouse models and human induced pluripotent stem cell (iPSC) derived neuronal models in conjunction with proteomics, cell biology, physiology, and functional imaging. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/chandra/publications/", + "publications": [ + "Yale School of Medicine /", + "Neurology /", + "Our Research Sreeganga Chandra", + "Sreeganga Chandra", + "Photo Galleries Our Lab Through the Years Lab Cakes Around the Lab 2021 Around the Lab 2022", + "Our Lab Through the Years", + "Lab Cakes", + "Around the Lab 2021", + "Around the Lab 2022", + "People Former Lab Members", + "Former Lab Members", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Our Research", + "People", + "Publications", + "News", + "Photo Galleries", + "", + "", + "", + "", + "", + "", + "Synaptic vesicle endocytosis deficits underlie cognitive dysfunction in mouse models of GBA-linked Parkinson's disease and dementia with Lewy bodies. Vidyadhara DJ, Bäckström D, Chakraborty R, Ruan J, Park JM, Mistry PK, Chandra SS. Nat Commun. 2025 Sep 26; 2025 Sep 26. PMID: 41006254.", + "Molecular elucidation of brain lipofuscin in aging and Neuronal Ceroid Lipofuscinosis. Tieze SM, Esqueda A, McAllister R, Lagator M, Yücel B, Sun E, Lam TT, Lockyer N, Gupta K, Chandra SS. Res Sq. 2025 Mar 19; 2025 Mar 19. PMID: 40166029.", + "Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson's disease and Dementia with Lewy bodies. Vidyadhara DJ, Bäckström D, Chakraborty R, Ruan J, Park JM, Mistry PK, Chandra SS. bioRxiv. 2025 Jan 2; 2025 Jan 2. PMID: 39484386.", + "Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson's disease and Dementia with Lewy bodies. Vidyadhara DJ, Bäckström D, Chakraborty R, Ruan J, Park JM, Mistry PK, Chandra SS. Res Sq. 2024 Dec 27; 2024 Dec 27. PMID: 39764119.", + "Single-cell transcriptomic and proteomic analysis of Parkinson's disease brains. Zhu B, Park JM, Coffey SR, Russo A, Hsu IU, Wang J, Su C, Chang R, Lam TT, Gopal PP, Ginsberg SD, Zhao H, Hafler DA, Chandra SS, Zhang L. Sci Transl Med. 2024 Oct 30; 2024 Oct 30. PMID: 39475571.", + "Decoding transcriptomic signatures of cysteine string protein alpha-mediated synapse maintenance. Wang N, Zhu B, Allnutt MA, Grijalva RM, Zhao H, Chandra SS. Proc Natl Acad Sci U S A. 2024 Jun 11; 2024 Jun 4. PMID: 38833477.", + "Impaired pre-synaptic plasticity and visual responses in auxilin-knockout mice. Cheng X, Tang Y, Vidyadhara DJ, Li BZ, Zimmerman M, Pak A, Nareddula S, Edens PA, Chandra SS, Chubykin AA. iScience. 2023 Oct 20; 2023 Sep 6. PMID: 37766983.", + "Decoding transcriptomic signatures of Cysteine String Protein alpha-mediated synapse maintenance. Wang N, Zhu B, Allnutt MA, Grijalva RM, Zhao H, Chandra SS. bioRxiv. 2023 Oct 3; 2023 Oct 3. PMID: 37873460.", + "α-Synuclein colocalizes with AP180 and affects the size of clathrin lattices. Vargas KJ, Colosi PL, Girardi E, Park JM, Harmon LE, Chandra SS. J Biol Chem. 2023 Sep; 2023 Jul 28. PMID: 37516240.", + "Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson's disease. Vidyadhara DJ, Somayaji M, Wade N, Yücel B, Zhao H, Shashaank N, Ribaudo J, Gupta J, Lam TT, Sames D, Greene LE, Sulzer DL, Chandra SS. Cell Rep. 2023 Mar 28; 2023 Mar 14. PMID: 36920906.", + "α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Martin-Lopez E, Vidyadhara DJ, Liberia T, Meller SJ, Harmon LE, Hsu RM, Spence N, Brennan B, Han K, Yücel B, Chandra SS, Greer CA. J Neurosci. 2023 Feb 8; 2023 Jan 3. PMID: 36596700.", + "Pharmacological Mechanism of the Non-hallucinogenic 5-HT(2A) Agonist Ariadne and Analogs. Cunningham MJ, Bock HA, Serrano IC, Bechand B, Vidyadhara DJ, Bonniwell EM, Lankri D, Duggan P, Nazarova AL, Cao AB, Calkins MM, Khirsariya P, Hwu C, Katritch V, Chandra SS, McCorvy JD, Sames D. ACS Chem Neurosci. 2023 Jan 4; 2022 Dec 15. PMID: 36521179.", + "A Markov random field model-based approach for differentially expressed gene detection from single-cell RNA-seq data. Zhu B, Li H, Zhang L, Chandra SS, Zhao H. Brief Bioinform. 2022 Sep 20. PMID: 35514182.", + "Subcellular Fractionation for the Isolation of Synaptic Components from the Murine Brain. Massaro Tieze S, Chandra SS, Vidyadhara DJ. J Vis Exp. 2022 Sep 14; 2022 Sep 14. PMID: 36190269.", + "Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function. Gorenberg EL, Massaro Tieze S, Yücel B, Zhao HR, Chou V, Wirak GS, Tomita S, Lam TT, Chandra SS. PLoS Biol. 2022 Mar; 2022 Mar 31. PMID: 35358180.", + "Hsp110 mitigates α-synuclein pathology in vivo. Taguchi YV, Gorenberg EL, Nagy M, Thrasher D, Fenton WA, Volpicelli-Daley L, Horwich AL, Chandra SS. Proc Natl Acad Sci U S A. 2019 Nov 26; 2019 Nov 4. PMID: 31685606.", + "A Drosophila model of neuronal ceroid lipofuscinosis CLN4 reveals a hypermorphic gain of function mechanism. Imler E, Pyon JS, Kindelay S, Torvund M, Zhang YQ, Chandra SS, Zinsmaier KE. Elife. 2019 Oct 30; 2019 Oct 30. PMID: 31663851.", + "Role of the endolysosomal system in Parkinson's disease. Vidyadhara DJ, Lee JE, Chandra SS. J Neurochem. 2019 Sep; 2019 Jul 31. PMID: 31287913.", + "Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease. Taguchi YV, Liu J, Ruan J, Pacheco J, Zhang X, Abbasi J, Keutzer J, Mistry PK, Chandra SS. J Neurosci. 2017 Oct 4; 2017 Aug 28. PMID: 28847804.", + "The Role of Co-chaperones in Synaptic Proteostasis and Neurodegenerative Disease. Gorenberg EL, Chandra SS. Front Neurosci. 2017; 2017 May 19. PMID: 28579939.", + "Synucleins Have Multiple Effects on Presynaptic Architecture. Vargas KJ, Schrod N, Davis T, Fernandez-Busnadiego R, Taguchi YV, Laugks U, Lucic V, Chandra SS. Cell Rep. 2017 Jan 3. PMID: 28052246.", + "Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation. Henderson MX, Wirak GS, Zhang YQ, Dai F, Ginsberg SD, Dolzhanskaya N, Staropoli JF, Nijssen PC, Lam TT, Roth AF, Davis NG, Dawson G, Velinov M, Chandra SS. Acta Neuropathol. 2016 Apr; 2015 Dec 10. PMID: 26659577.", + "Oligomerization of Cysteine String Protein alpha mutants causing adult neuronal ceroid lipofuscinosis. Zhang YQ, Chandra SS. Biochim Biophys Acta. 2014 Nov; 2014 Jul 23. PMID: 25064588.", + "Synucleins regulate the kinetics of synaptic vesicle endocytosis. Vargas KJ, Makani S, Davis T, Westphal CH, Castillo PE, Chandra SS. J Neurosci. 2014 Jul 9. PMID: 25009269.", + "Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration. Bilguvar K, Tyagi NK, Ozkara C, Tuysuz B, Bakircioglu M, Choi M, Delil S, Caglayan AO, Baranoski JF, Erturk O, Yalcinkaya C, Karacorlu M, Dincer A, Johnson MH, Mane S, Chandra SS, Louvi A, Boggon TJ, Lifton RP, Horwich AL, Gunel M. Proc Natl Acad Sci U S A. 2013 Feb 26; 2013 Jan 28. PMID: 23359680.", + "Monomeric synucleins generate membrane curvature. Westphal CH, Chandra SS. J Biol Chem. 2013 Jan 18; 2012 Nov 26. PMID: 23184946.", + "Identification of CSPα clients reveals a role in dynamin 1 regulation. Zhang YQ, Henderson MX, Colangelo CM, Ginsberg SD, Bruce C, Wu T, Chandra SS. Neuron. 2012 Apr 12. PMID: 22500636.", + "αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction. Greten-Harrison B, Polydoro M, Morimoto-Tomita M, Diao L, Williams AM, Nie EH, Makani S, Tian N, Castillo PE, Buchman VL, Chandra SS. Proc Natl Acad Sci U S A. 2010 Nov 9; 2010 Oct 25. PMID: 20974939.", + "Imler, E., Pyon, J., Zhang, Y., Chandra, S.S ., Zinsmaier, K.E. (2019). A Drosophila model of neuronal ceroid lipofuscinosis induced by dominant mutations in human CSPa. I _n bioRxiv: https://www.biorxiv.org/content/10.1101/579771v1", + "Chandra, S. (2009) , Synucleins, In: Squire, L. (Ed.), New Encyclopedia of Neuroscience. Vol. 9, Oxford: Academic Press, pp 833-837.", + "Chandra, S., Sudhof, T.C. (2008) , Alpha-Synuclein, CSPalpha, SNAREs and neuroprotection in vivo., Parkinson's disease: Molecular and Therapeutic Insights from Model Systems, New York, Academic Press, 295-308", + "Boyer Center for Molecular Medicine 295 Congress Avenue New Haven, CT 06510", + "1 Event you could attend in November 2025 Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Chang Lab", + "lab_url": "https://medicine.yale.edu/lab/chang/", + "research_bio": "INFORMATION FOR The communication between visceral organs and the brain is essential for our daily life! In the Chang lab, we use molecular biology, optogenetics, virus-based anatomical tracing, in vivo imaging, and mouse genetics to study how our brain senses internal changes and controls body organ functions. The Chang lab is constantly seeking for motivated people to join the team! Please contact Rui atrui.chang@yale.edu. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/chang/publications/", + "publications": [ + "Yale School of Medicine /", + "Neuroscience /", + "Research", + "Gallery", + "People", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "News", + "Gallery", + "", + "", + "", + "", + "", + "", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Chawarska Lab", + "lab_url": "https://medicine.yale.edu/lab/chawarska/", + "research_bio": "INFORMATION FOR Copy Link Copy Link The Tom Ficklin Radio Show, the Yale Center for Clinical Investigation (YCCI), and their AME Zion Church Cultural Ambassadors for Research at Yale, have launched a new partnership to raise awareness in the minority community on health promotion topics and how to access cutting-edge clinical research. To kick off Autism Awareness Month on April 4, 2022, the Yale Social and Affective Neuroscience of Autism Program's principal investigator Dr. Katarzyna Chawarska along with clinical psychologists Dr. Kelly Powell and Dr. Mariana Torres-Viso joined with members of the Cultural Ambassadors to discuss the advances the team has made in autism research to aid children and families.", + "publications_page": "https://medicine.yale.edu/lab/chawarska/participate/pubs", + "publications": [ + "Yale School of Medicine /", + "Child Study Center /", + "Autism Center of Excellence Who are we? What are the studies? Prenatal Study Neonatal Study Toddler Study School-age Siblings Study Biological Markers Study Contact and Locations News", + "Who are we?", + "What are the studies? Prenatal Study Neonatal Study Toddler Study School-age Siblings Study Biological Markers Study", + "Prenatal Study", + "Neonatal Study", + "Toddler Study", + "School-age Siblings Study", + "Biological Markers Study", + "Contact and Locations", + "News", + "Jobs", + "News", + "Research Studies Newborns and Infants Young Children Publications", + "Newborns and Infants", + "Young Children", + "Publications", + "Contact Us", + "People Collaborators Alumni", + "Collaborators", + "Alumni", + "Newsletters SANA Lab Blog", + "SANA Lab Blog", + "Clinical Services", + "Video Library", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Home", + "Research Studies", + "Newborns and Infants", + "Young Children", + "Publications", + "", + "", + "", + "", + "", + "", + "Functional Connectivity in the Social Perception Pathway at Birth Is Linked to Attention to Faces at Four Months. Chawarska K, Vernetti A, Sun H, Hampson M, Li C, Macari S, Powell K, Constable RT, Chang J, Ment LR, Scheinost D. Biol Psychiatry Glob Open Sci. 2025 Nov; 2025 Aug 19. PMID: 41127567.", + "Do in-scanner tasks outperform rest for predicting autistic traits using functional connectivity data? Horien C, Mandino F, Greene AS, Shen X, Powell K, Vernetti A, O'Connor D, Adkinson BD, Tejavibulya L, McPartland JC, Volkmar FR, Chun M, Chawarska K, Lake EMR, Rosenberg MD, Satterthwaite T, Scheinost D, Finn E, Constable RT. medRxiv. 2025 Sep 16; 2025 Sep 16. PMID: 39867399.", + "Motor stereotypies in toddlers with and without autism: A transdiagnostic dimension. Chawarska K, Fernandez TV, Milgramm A, Volkmar F, Torres-Viso M, Powell K, Vernetti A, Macari S, Morgan C. J Child Psychol Psychiatry. 2025 Aug 4; 2025 Aug 4. PMID: 40757458.", + "Sex-Related Measurement Bias in Autism Spectrum Disorder Symptoms in the Baby Siblings Research Consortium. Burrows CA, Sung S, Zheng S, Young GS, Charman T, Klaiman C, Klin A, Marrus N, Ozonoff S, Piven J, Robins DL, Schmidt RJ, Schwichtenberg AJ, Webb SJ, Zwaigenbaum L, Carver LJ, Chawarska K, Curtin S, Jeste SS, Iverson JM, Landa RJ, Messinger DS, Roberts JE, Stone WL, Tager-Flusberg H, Esler AN, Miller M, Bishop SL, Elison JT. JAMA Netw Open. 2025 Aug 1; 2025 Aug 1. PMID: 40779266.", + "Understanding Motor Stereotypies as a Transdiagnostic Phenotype. Garrido-Torres N, Carney AG, Lyons M, Macari S, Morgan C, Powell K, Torres-Viso M, Vernetti A, Chawarska K, Fernandez TV. J Am Acad Child Adolesc Psychiatry. 2025 Aug; 2025 Mar 14. PMID: 40090545.", + "Enhancer-driven gene regulatory network of forebrain human development provides insights into autism. Jourdon A, Mariani J, Natu A, Wu F, Li B, Capauto D, Hagy KT, Norton S, Tomasini L, Safi A, Amiri A, Schreiner J, Nguyen CK, Nolan N, Nelson MP, Ramos DM, Ward ME, Szekely A, McPartland JC, Pelphrey K, Ventola P, Chawarska K, Gersbach CA, Crawford GE, Abyzov A, Vaccarino FM. bioRxiv. 2025 May 11; 2025 May 11. PMID: 40654911.", + "Disrupted Resting-State Functional Connectivity in the Social Visual Pathway in Children With Autism Spectrum Disorder. Li C, Park H, Awasthi J, Rolison M, Li M, Scheinost D, Chawarska K, Hampson M. Autism Res. 2025 May; 2025 Apr 4. PMID: 40183221.", + "Longitudinal relationships between social anhedonia and internalizing symptoms in autistic children: results from the Autism Biomarkers Consortium for Clinical Trials. Gerber AH, Naples A, Chawarska K, Dawson G, Kleinhans N, Jeste S, Faja S, Dziura J, Webb S, Sugar C, Shic F, Levin AR, McPartland JC. Psychol Med. 2025 Apr 2; 2025 Apr 2. PMID: 40170613.", + "Clinician-caregiver informant discrepancy is associated with sex, diagnosis age, and intervention use among autistic children. Azu MA, Han GT, Wolf JM, Naples AJ, Chawarska K, Dawson G, Bernier RA, Jeste SS, Dziura JD, Webb SJ, Sugar CA, Shic F, McPartland JC. Autism. 2025 Mar; 2024 Sep 30. PMID: 39344965.", + "Functional connectivity in the social perception pathway at birth is linked with attention to faces at 4 months. Chawarska K, Vernetti A, Sun H, Hampson M, Li C, Macari S, Powell K, Constable RT, Chang J, Ment L, Scheinost D. bioRxiv. 2025 Feb 27; 2025 Feb 27. PMID: 40060551.", + "White-matter controllability at birth predicts social engagement and language outcomes in toddlerhood. Sun H, Vernetti A, Spann M, Chawarska K, Ment L, Scheinost D. bioRxiv. 2025 Feb 19; 2025 Feb 19. PMID: 40027793.", + "Spatiotemporal Eye Movement Dynamics Reveal Altered Face Prioritization in Early Visual Processing Among Autistic Children. 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Nature. 2012 Dec 20; 2012 Nov 18. PMID: 23160490.", + "Predicting developmental status from 12 to 24 months in infants at risk for Autism Spectrum Disorder: a preliminary report. Macari SL, Campbell D, Gengoux GW, Saulnier CA, Klin AJ, Chawarska K. J Autism Dev Disord. 2012 Dec. PMID: 22484794.", + "Context modulates attention to social scenes in toddlers with autism. Chawarska K, Macari S, Shic F. J Child Psychol Psychiatry. 2012 Aug; 2012 Mar 17. PMID: 22428993.", + "Practitioner's guide to assessment of autism spectrum disorders in infants and toddlers. Steiner AM, Goldsmith TR, Snow AV, Chawarska K. J Autism Dev Disord. 2012 Jun. PMID: 22057879.", + "Early generalized overgrowth in boys with autism. Chawarska K, Campbell D, Chen L, Shic F, Klin A, Chang J. Arch Gen Psychiatry. 2011 Oct. PMID: 21969460.", + "Brief report: face-specific recognition deficits in young children with autism spectrum disorders. Bradshaw J, Shic F, Chawarska K. J Autism Dev Disord. 2011 Oct. PMID: 21373955.", + "Phonology and vocal behavior in toddlers with autism spectrum disorders. Schoen E, Paul R, Chawarska K. Autism Res. 2011 Jun; 2011 Feb 9. PMID: 21308998.", + "Limited activity monitoring in toddlers with autism spectrum disorder. Shic F, Bradshaw J, Klin A, Scassellati B, Chawarska K. Brain Res. 2011 Mar 22; 2010 Dec 1. PMID: 21129365.", + "Limited attentional bias for faces in toddlers with autism spectrum disorders. Chawarska K, Volkmar F, Klin A. Arch Gen Psychiatry. 2010 Feb. PMID: 20124117.", + "Looking but not seeing: atypical visual scanning and recognition of faces in 2 and 4-year-old children with autism spectrum disorder. Chawarska K, Shic F. J Autism Dev Disord. 2009 Dec; 2009 Jul 10. PMID: 19590943.", + "A prospective study of toddlers with ASD: short-term diagnostic and cognitive outcomes. Chawarska K, Klin A, Paul R, Macari S, Volkmar F. J Child Psychol Psychiatry. 2009 Oct; 2009 Jul 6. PMID: 19594835.", + "Screening for autism in older and younger toddlers with the Modified Checklist for Autism in Toddlers. Pandey J, Verbalis A, Robins DL, Boorstein H, Klin AM, Babitz T, Chawarska K, Volkmar F, Green J, Barton M, Fein D. Autism. 2008 Sep. PMID: 18805945.", + "The modified checklist for autism in toddlers: a follow-up study investigating the early detection of autism spectrum disorders. Kleinman JM, Robins DL, Ventola PE, Pandey J, Boorstein HC, Esser EL, Wilson LB, Rosenthal MA, Sutera S, Verbalis AD, Barton M, Hodgson S, Green J, Dumont-Mathieu T, Volkmar F, Chawarska K, Klin A, Fein D. J Autism Dev Disord. 2008 May. PMID: 17882539.", + "Language outcomes of toddlers with autism spectrum disorders: a two year follow-up. Paul R, Chawarska K, Cicchetti D, Volkmar F. Autism Res. 2008 Apr. PMID: 19360656.", + "Autism in infants: an update. Volkmar FR, Chawarska K. World Psychiatry. 2008 Feb. PMID: 18458791.", + "Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Bakkaloglu B, O'Roak BJ, Louvi A, Gupta AR, Abelson JF, Morgan TM, Chawarska K, Klin A, Ercan-Sencicek AG, Stillman AA, Tanriover G, Abrahams BS, Duvall JA, Robbins EM, Geschwind DH, Biederer T, Gunel M, Lifton RP, State MW. Am J Hum Genet. 2008 Jan. PMID: 18179895.", + "\"Listen my children and you shall hear\": auditory preferences in toddlers with autism spectrum disorders. Paul R, Chawarska K, Fowler C, Cicchetti D, Volkmar F. J Speech Lang Hear Res. 2007 Oct. PMID: 17905916.", + "Quantifying Behavioral Inhibition to Unfamiliar Social and Non-Social Stimuli in Toddlers with ASD. C. Banarjee, V. Donthireddy, E. Diamond, A. Boxberger, K. All, R. Foster, B. Gordon, E. Brennan-Wydra, A. Vernetti, S. Macari, K. Chawarska, K. (2022). Poster presented at International Society for Autism Research Annual Meeting, Austin, TX.", + "Regulatory Strategies, Emotional Expression, and Physiological Responses during a Frustration Eliciting Task in Toddlers with and without ASD. A. Boxberger, E. Diamond, C. Banarjee, R. Foster, K. All, B. Gordon, V. Donthireddy, E. Brennan-Wydra, K. K. Powell, S. Macari, A. Vernetti, K. Chawarska (2022). Poster presented at International Society for Autism Research Annual Meeting, Austin, TX.", + "Sharing Joy during Puppet Shows: Toddler with Autism Spectrum Disorder Share Positive Affect as Frequently as Typically Developing Controls. E. Diamond, K. All, B. Gordon, C. Banarjee, R. Foster, A. Boxberger, V. Donthireddy, E. Brennan-Wydra, A. Vernetti, S. Macari, K. Chawarska (2022). Poster presented at International Society for Autism Research Annual Meeting, Austin, TX.", + "Longitudinal Development of Real-World Executive Function Skills in Preschoolers with Autism Spectrum Disorder. R. Foster, K. All, C. Banarjee, E. Diamond, B. Gordon, V. Donthireddy, K. K. Powell, E. Brennan-Wydra, A. Vernetti, S. Macari, K. Chawarska (2022). Poster presented at International Society for Autism Research Annual Meeting, Austin, TX.", + "Puppets Facilitate Attention to Social Cues in Children with ASD. S. Macari, X. E. Chen, L. Brunissen, E. Yhang, E. Brennan-Wydra, A. Vernetti, F. R. Volkmar, J. Chang, K. Chawarska (2022). Poster presented at International Society for Autism Research Annual Meeting, Austin, TX.", + "Internalizing and Externalizing Symptoms Are Elevated in 3-Year-Olds with ASD and Are Predicted by Temperamental Features at Age 2. S. Macari, K. K. Powell, E. Diamond, E. Brennan-Wydra, A. Vernetti, K. Chawarska (2022). Poster presented at International Society for Autism Research Annual Meeting, Austin, TX.", + "Symptoms of Executive Dysfunction and ADHD Are Linked with Poorer Adaptive Functioning in 3-Year-Olds with ASD. K. K. Powell, S. Macari, E. Brennan-Wydra, H. Feiner, M. Butler, D. M. Goncalves Fortes, A. Boxberger, C. Morgan, M. Lyons, M. S. Torres-Viso, K. Chawarska (2022). Poster presented at International Society for Autism Research Annual Meeting, Austin, TX.", + "A Demonstration of Limited Attention to Parents' Faces during a Live Eye-Tracking Task in Toddlers with Elevated Autism Symptoms. A. Vernetti, C. Banarjee, A. Boxberger, E. Diamond, K. All, S. Macari, K. Chawarska (2022). Poster presented at International Society for Autism Research Annual Meeting, Austin, TX.", + "Functional Brain Development during Neonatal and Infancy Periods in Neurodiverse Populations. K. Chawarska (2022). Panel presented at International Society for Autism Research Annual Meeting, Austin, TX. Establishing a Platform for Early Childhood Development: MRI Studies of the Structure and Function of the Neonatal Brain (D. Fenchel, J. Ciarrusta, A. Uus, M. Deprez, R. Dimitrova, J. V. Hajnal, E. Hughes, A. Javed, C. Nosarti, D. Murphy, T. Arichi, A. D. Edwards, D. Batalle, J. O Muircheartaigh, G. M. McAlonan) Salience Network Functional Connectivity in Neonates with High Likelihood of Autism (D. Scheinost, J. Chang, C. Lacadie, E. Brennan-Wydra, R. T. Constable, L. R. Ment, K. Chawarska) Predictive Links between Salience Network Connectivity and Attention to Social Partners in Neonates with Familial History of Autism (A. Vernetti, R. Ray, D. Scheinost, L. R. Ment, S. Macari, H. Neiderman, C. Nutor, C. D. Gershman, H. Feiner, R. Foster, R. T. Constable, J. Chang, K. Chawarska) Altered Theta-Beta Ratios in Infants at Elevated Likelihood of Neurodevelopmental Disorders (J. Begum Ali, A. Goodwin, L. Mason, G. Pasco, T. Charman, M. H. Johnson, E. J. Jones)", + "Establishing a Platform for Early Childhood Development: MRI Studies of the Structure and Function of the Neonatal Brain (D. Fenchel, J. Ciarrusta, A. Uus, M. Deprez, R. Dimitrova, J. V. Hajnal, E. Hughes, A. Javed, C. Nosarti, D. Murphy, T. Arichi, A. D. Edwards, D. Batalle, J. O Muircheartaigh, G. M. McAlonan)", + "Salience Network Functional Connectivity in Neonates with High Likelihood of Autism (D. Scheinost, J. Chang, C. Lacadie, E. Brennan-Wydra, R. T. Constable, L. R. Ment, K. Chawarska)", + "Predictive Links between Salience Network Connectivity and Attention to Social Partners in Neonates with Familial History of Autism (A. Vernetti, R. Ray, D. Scheinost, L. R. Ment, S. Macari, H. Neiderman, C. Nutor, C. D. Gershman, H. Feiner, R. Foster, R. T. Constable, J. Chang, K. Chawarska)", + "Altered Theta-Beta Ratios in Infants at Elevated Likelihood of Neurodevelopmental Disorders (J. Begum Ali, A. Goodwin, L. Mason, G. Pasco, T. Charman, M. H. Johnson, E. J. Jones)", + "Impact of COVID-19 on Implementation of Live Eye-Tracking Research Procedures and Social Attention in Toddlers. M. Butler, R. Foster, C. Banarjee, H. Feiner, D. Goncalves Fortes, E. Diamond, E. Brennan-Wydra, A. Boxberger, S. Macari, A. Vernetti, K. Chawarska (2021). Poster presented at the International Society for Autism Research Annual Meeting (virtual conference).", + "Exploration of Anxiety Symptoms in Three-Year-Olds with and without ASD Reveals Distinctive Symptom Structure. D. Goncalves Fortes, C. Banarjee, H. Feiner, M. Butler, E. Diamond, R. Foster, A. Boxberger, E. Brennan-Wydra, S. Macari, K. Chawarska (2021). Poster presented at the International Society for Autism Research Annual Meeting (virtual conference).", + "Increased Attention to the Mouth at 12 Months Predicts Language Outcomes in Infants at Low-Risk but Not Elevated-Risk for ASD. H. Feiner, E. Diamond, C. Banarjee, D. Goncalves Fortes, M. Butler, R. Foster, A. Boxberger, F. Shic, E. Brennan-Wydra, A. Vernetti, S. Macari, D. Lewkowicz, K. Chawarska (2021). Talk presented at the International Society for Autism Research Annual Meeting (virtual conference).", + "Language Profiles in Toddlers with Autism Spectrum Disorders and Developmental Delay: A Function of Assessment Tools? C. D. Gershman, H. Feiner, M. Lyons, N. Powell, C. Nutor, K. Joseph, M. Butler, D. M. Goncalves Fortes, A. Vernetti, S. Macari, K. Chawarska (2020). Poster presented at the International Society for Autism Research Annual Meeting (virtual conference).", + "The Accuracy of a Digitally-Administered M-CHAT in a Diverse Community Sample: Preliminary Findings. C. Nutor, K. Joseph, N. Powell, C. D. Gershman, E. Yhang, D. M. Goncalves Fortes, M. Butler, H. Feiner, A. Vernetti, K. Chawarska, F. Shic, S. Macari (2020). Poster presented at the International Society for Autism Research Annual Meeting (virtual conference).", + "Negative Emotional Reactivity, Effortful Control, and Self-Regulatory Strategies in Toddlers with ASD. N. Powell, M. Butler, E. Yhang, C. Nutor, C. D. Gershman, K. Joseph, D. M. Goncalves Fortes, H. Feiner, K. K. Powell, S. Macari, A. Vernetti, K. Chawarska (2020). Poster presented at the International Society for Autism Research Annual Meeting (virtual conference).", + "Is Effortful Control Related to Social Competence in Toddlers with Autism Spectrum Disorder? E. Yhang, D. M. Goncalves Fortes, N. Powell, C. Nutor, C. D. Gershman, K. Joseph, M. Butler, H. Feiner, S. Macari, A. Vernetti, K. Chawarska (2020). Poster presented at the International Society for Autism Research Annual Meeting (virtual conference).", + "Associations between Fear and Later Anxiety and Internalizing Symptoms in Very Young Children with ASD . K. Joseph, C. Nutor, H. Neiderman, K. Villarreal, C. D. Gershman, N. Powell, E. Yhang, F. E. Kane-Grade, A. Vernetti, S. Fontenelle, K. K. Powell, K. Chawarska, S. Macari (2019). Poster presented at the International Society for Autism Research Annual Meeting, Montreal, Canada.", + "Links between Positive Emotionality and Later Comorbid Symptoms in Toddlers with ASD. S. Macari, K. Joseph, H. Neiderman, F. E. Kane-Grade, K. Villarreal, C. D. Gershman, C. Nutor, N. Powell, E. Yhang, S. Fontenelle, T. Tsang, K. K. Powell, A. Vernetti, K. Chawarska (2019). Poster presented at the International Society for Autism Research Annual Meeting, Montreal, Canada.", + "Attenuated Attention to People but Not Humanoid Puppet Figures in Children with Autism Spectrum Disorder. H. Neiderman, N. Powell, E. Yhang, K. Joseph, K. Villarreal, C. Nutor, C. D. Gershman, Q. Wang, K. K. Powell, S. Fontenelle, S. Macari, K. Chawarska, T. Tsang (2019). Poster presented at the International Society for Autism Research Annual Meeting, Montreal, Canada.", + "Prospective Associations between Anger and Later Internalizing Symptoms in Young Children with ASD. K. K. Powell, K. Joseph, F. E. Kane-Grade, H. Neiderman, K. Villarreal, C. D. Gershman, C. Nutor, N. Powell, E. Yhang, S. Fontenelle, T. Tsang, A. Vernetti, K. Chawarska, S. Macari (2019). Poster presented at the International Society for Autism Research Annual Meeting, Montreal, Canada.", + "Attenuated Attentional and Behavioral Vigilance Towards Nonsocial Threats in Preschoolers with Autism Spectrum Disorder. C. D. Ramsey, E. Hilton, G. Greco, C. D. Gershman, K. Joseph, H. Neiderman, C. Nutor, N. Powell, K. Villarreal, E. Yhang, S. Fontenelle, K. K. Powell, T. Tsang, S. Macari, K. Chawarska, A. Vernetti (2019). Poster presented at the International Society for Autism Research Annual Meeting, Montreal, Canada.", + "Social Monitoring of Conversation Partners in Young Children with ASD. T. Tsang, E. Yhang, C. Gershman, K. Joseph, H. Neiderman, C. Nutor, N. Powell, K. Villarreal, A. Vernetti, S. Macari, K. Chawarska (2019). Poster presented at the International Society for Autism Research Annual Meeting, Montreal, Canada.", + "Atypical Physiological Responses to Emotion-Eliciting Challenges in Preschoolers with ASD. A. Vernetti, N. Powell, C. D. Ramsey, K. Villarreal, F. E. Kane-Grade, H. Neiderman, K. Joseph, C. D. Gershman, C. Nutor, E. Yhang, S. Fontenelle, K. K. Powell, T. Tsang, F. Shic, M. S. Goodwin, S. Macari, K. Chawarska (2019). Poster presented at the International Society for Autism Research Annual Meeting, Montreal, Canada.", + "Attention to Speaker's Mouth Region in Toddlers Predict Language and Autism Severity Levels in Preschool Aged Children. K. Villarreal, C. D. Gershman, N. Powell, H. Neiderman, K. Joseph, E. Yhang, F. Shic, Q. Wang, S. Macari, M. Lyons, K. Chawarska, C. Nutor (2019). Poster presented at the International Society for Autism Research Annual Meeting, Montreal, Canada.", + "How Does It Feel? Emotional Lives of Toddlers with ASD. K. Chawarska, C. A. Mazefsky (2018). Panel presented at the International Society for Autism Research Annual Meeting, Rotterdam, Netherlands. Attenuated Fear and Accentuated Frustration Responses to Real-World Challenges Aimed at Eliciting Negative Emotions (S. Macari, F. E. Kane-Grade, E. Hilton, A. Milgramm, P. Heymann, L. DiNicola, D. Macris, K. K. Powell, S. Fontenelle, M. Lyons, A. Giguere Carney, K. Bailey, F. Shic, K. Chawarska) Do Toddlers with ASD Express Emotions That Are Incongruent with Valence of Real-World Events? (F. E. Kane-Grade, S. Macari, K. Villarreal, A. Zakin, H. Neiderman, M. Wilkinson, E. Hilton, A. Milgramm, P. Heymann, L. DiNicola, D. Macris, K. K. Powell, S. Fontenelle, M. Lyons, K. Chawarska) Decreased Fear Response in Toddlers with ASD Is Linked with Attenuated Changes in Physiological Arousal (L. Boccanfuso, F. Shic, S. Macari, L. DiNicola, A. Milgramm, E. Hilton, F. E. Kane-Grade, P. Heymann, M. S. Goodwin, A. Vernetti, K. Chawarska) Attentional Capture By Angry Faces and Angry Voices Is Associated with Intensity of Fear Induced By Real-World Challenges in Toddlers with ASD (K. Chawarska, F. Shic, Q. Wang, A. Vernetti, D. Macris, S. Macari)", + "Attenuated Fear and Accentuated Frustration Responses to Real-World Challenges Aimed at Eliciting Negative Emotions (S. Macari, F. E. Kane-Grade, E. Hilton, A. Milgramm, P. Heymann, L. DiNicola, D. Macris, K. K. Powell, S. Fontenelle, M. Lyons, A. Giguere Carney, K. Bailey, F. Shic, K. Chawarska)", + "Do Toddlers with ASD Express Emotions That Are Incongruent with Valence of Real-World Events? (F. E. Kane-Grade, S. Macari, K. Villarreal, A. Zakin, H. Neiderman, M. Wilkinson, E. Hilton, A. Milgramm, P. Heymann, L. DiNicola, D. Macris, K. K. Powell, S. Fontenelle, M. Lyons, K. Chawarska)", + "Decreased Fear Response in Toddlers with ASD Is Linked with Attenuated Changes in Physiological Arousal (L. Boccanfuso, F. Shic, S. Macari, L. DiNicola, A. Milgramm, E. Hilton, F. E. Kane-Grade, P. Heymann, M. S. Goodwin, A. Vernetti, K. Chawarska)", + "Attentional Capture By Angry Faces and Angry Voices Is Associated with Intensity of Fear Induced By Real-World Challenges in Toddlers with ASD (K. Chawarska, F. Shic, Q. Wang, A. Vernetti, D. Macris, S. Macari)", + "A Multimedia Screening System to Predict ASD Symptoms in Diverse Community Settings: Preliminary Convergent and Concurrent Validity. S. Macari, K. Chawarska, M. Wilkinson, E. Barney, J. C. Snider, E. S. Kim, Q. Wang, Q. A. Yang, C. A. Wall, B. Li, M. Mademtzi, C. Foster, D. Macris, F. E. Kane-Grade, A. Milgramm, P. Heymann, E. Hilton, A. Zakin, H. Neiderman, K. Villarreal, K. K. Powell, S. Fontenelle, M. Lyons, A. Giguere Carney, K. Bailey, M. Kim, Y. A. Ahn, M. C. Aubertine, F. Shic (2018). Talk presented at the International Society for Autism Research Annual Meeting, Rotterdam, Netherlands.", + "First Year Inventory Attention Constructs in Infants at Risk for Autism Spectrum Disorders. D. Macris, S. Macari, K. K. Powell, S. Fontenelle, M. Lyons, A. Giguere Carney, K. Bailey K. Chawarska (2018). Poster presented at the International Society for Autism Research Annual Meeting, Rotterdam, Netherlands.", + "Concurrent Associations between FYI Attentional Constructs and ADOS Scores in 12-Month High-Risk Siblings. H. Neiderman, S. Macari, A. Zakin, F. E. Kane-Grade, K. Villarreal, M. Wilkinson, D. Macris, S. Fontenelle, K. K. Powell, M. Lyons, K. Chawarska (2018). Poster presented at the International Society for Autism Research Annual Meeting, Rotterdam, Netherlands.", + "A Multimedia Screening System to Predict Later ASD Symptoms in Diverse Community Settings: A Machine-Learning Design for Infants and Toddlers. F. Shic, K. Chawarska, E. S. Kim, C. A. Wall, M. Wilkinson, E. Barney, J. C. Snider, Q. Wang, Q. A. Yang, M. Kim, B. Li, M. Mademtzi, C. Foster, D. Macris, F. E. Kane-Grade, A. Milgramm, P. Heymann, E. Hilton, A. Zakin, H. Neiderman, K. Villarreal, K. K. Powell, S. Fontenelle, M. Lyons, A. Giguere Carney, K. Bailey, Y. A. Ahn, M. C. Aubertine, S. Macari (2018). Technology demonstration at the International Society for Autism Research Annual Meeting, Rotterdam, Netherlands.", + "Consistency between Parent-Report and Direct Measure of Toddler Temperament. K. Villarreal, S. Macari, H. Neiderman, F. E. Kane-Grade, M. Wilkinson, A. Zakin, D. Macris, L. DiNicola, P. Heymann, A. Milgramm, E. Hilton, K. Chawarska (2018). Poster presented at the International Society for Autism Research Annual Meeting, Rotterdam, Netherlands.", + "Domain-Specific Impairment in Flexible Value Learning in Young Children with ASD. Q. Wang, L. DiNicola, P. Heymann, M. Hampson, K. Chawarska (2018). Talk presented at the International Society for Autism Research Annual Meeting, Rotterdam, Netherlands.", + "Modifying Social Attention with Gaze-Contingent Eye Tracking for Toddlers and Children with ASD. Q. Wang, E. Barney, C. A. Wall, S. Macari, K. Chawarska, F. Shic (2018). Poster presented at the International Society for Autism Research Annual Meeting, Rotterdam, Netherlands.", + "Tracking Toddlers' Head Movement with Facial Landmarks during the Viewing of a Social Scene. Q. Wang, A. Milgramm, S. Macari, K. Chawarska (2018). Poster presented at the International Society for Autism Research Annual Meeting, Rotterdam, Netherlands.", + "Deployment of a Multimedia Screening Tool for ASD in a Diverse Community Setting: Feasibility and Usability. M. Wilkinson, S. Macari, K. Chawarska, E. Barney, J. C. Snider, E. S. Kim, Q. Wang, Q. A. Yang, C. A. Wall, M. Kim, B. Li, M. Mademtzi, C. Foster, D. Macris, F. E. Kane-Grade, A. Milgramm, P. Heymann, E. Hilton, A. Zakin, H. Neiderman, K. Villarreal, Y. A. Ahn, M. C. Aubertine, F. Shic (2018). Poster presented at the International Society for Autism Research Annual Meeting, Rotterdam, Netherlands.", + "Emotional Response Coherence in Toddlers with ASD. A. Zakin, S. Macari, F. E. Kane-Grade, K. Villarreal, H. Neiderman, M. Wilkinson, E. Hilton, A. Milgramm, P. Heymann, L. DiNicola, D. Macris, K. K. Powell, S. Fontenelle, M. Lyons, K. Chawarska (2018). Poster presented at the International Society for Autism Research Annual Meeting, Rotterdam, Netherlands.", + "Positive Affective Response to Dynamic Smiling Faces in Young Children with Autism Spectrum Disorder . P. Heymann, S. Macari, E. Hilton, A. Milgramm, F. Kane-Grade, K. Chawarska, L. DiNicola (2017). Talk presented at the International Meeting for Autism Research, San Francisco, CA.", + "Preserved Play in Females at High Risk for ASD Across the Range of Symptom Severity. E. Hilton, P. Heymann, S. Macari, A. Milgramm, F. Kane-Grade, K. Chawarska (2017). Poster presented at the International Meeting for Autism Research, San Francisco, CA.", + "Positive Affect in Infants at High Risk for ASD: A Multimethod Longitudinal Analysis. F. Kane-Grade, S. Macari, A. Milgramm, E. Hilton, P. Heymann, K. Chawarska (2017). Poster presented at the International Meeting for Autism Research, San Francisco, CA.", + "Now You See It, Now You Don't: Context-Dependent Dyadic Vulnerabilities in Infants with ASD in the First Year of Life . S. Macari, A. Milgramm, P. Heymann, E. Hilton, K. Chawarska, F. Kane-Grade (2017). Talk presented at the International Meeting for Autism Research, San Francisco, CA.", + "Patterns of Face Gaze Among Infants at Risk for ASD. A. Milgramm, S. Macari, F. Kane-Grade, P. Heymann, E. Hilton, K. Chawarska (2017). Talk presented at the International Meeting for Autism Research, San Francisco, CA.", + "Eye Tracking As a Spectrum of Biomarkers in Children with ASD. F. Shic, Q. Wang, A. Naples, S. Macari, K. Chawarska (2017). Talk presented at the International Meeting for Autism Research, San Francisco, CA.", + "Comparison of Neural Response to Language in Infants at Elevated Risk for ASD and in Infants with Nonsyndromic Craniosynostosis. A. Sun, M. Rolison, T. Halligan, C. Chuang, J. Yang, P. Hashim, K. Chawarska, D. Steinbacher, N. Landi, L. Mayes, J. Persing, J. McPartland (2017). Poster presented at the International Meeting for Autism Research, San Francisco, CA.", + "Child-Directed Play-Based Identification of Sensory Preferences: A Report on the Sensory Toy Box Experience with ASD and TD Children . S. Valencia, M. Mademtzi, P. Ventola, K. Chawarska, F. Shic (2017). Tech Demo presented at the International Meeting for Autism Research, San Francisco, CA.", + "Attentional signatures of autism in infancy: Studies of siblings at risk for ASD . K. Chawarska. (2016). International College of Neuropsychopharmacology, World Congress, Seoul, Korea.", + "Eye tracking in between: Gaze behaviors ion structural trial component in toddlers with ASD. F. Shic, Q. Wang, C. A. Wall, A. Naples, S. Macari, and K. Chawarska. (2016). Talk presented at the International Meeting for Autism Research, Baltimore, MD.", + "Attention capture by faces within naturalistic scenes is toddlers with ASD . DiNicola, F. Shic, S. F. Fontenelle, K. Powell, S. Macari and K. Chawarska. (2016). Talk presented at the International Meeting for Autism Research, Baltimore, MD.", + "Combining multiple eye tracking measures at 6 months in infant siblings: Associations with outcomes . F. Shic, Q. Wang, S. Macari, and K. Chawarska. (2016). Talk presented at the International Meeting for Autism Research, Baltimore, MD.", + "Social scene manipulation through gaze-contingent interfaces: Towards automated gaze strategy instruction for young children with ASD. Q. Wang, E. S. Kim, C. A. Wall, E. Barney, Y. Ahn, C. Foster, M. Mademtzi, M. Perlmutter, S. Macari, K. Chawarska, & F. Shic (2016). Poster presented at the International Meeting for Autism Research, Baltimore, MD.", + "Early predictors of restricted and repetitive behaviors in toddlers at risk for ASD. S. F. Fontenelle, D. Macris, K. Powell, S. Macari, and K. Chawarska. (2016). Poster presented at the International Meeting for Autism Research, Baltimore, MD.", + "Stability of atypical developmental outcomes in young children at risk for developing ASD. K. Powell, S. Macari, E. Hilton, S. F. Fontenelle, J. Koller, & K. Chawarska. (2016). Poster presented at the International Meeting for Autism Research, Baltimore, MD.", + "Social emotion regulation strategies in toddlers with ASD. A. Milgramm, S. Macari, L. DiNicola, P. Heymann, E. Hilton, K. Powell, … and K. Chawarska. (2016). Poster presented at the International Meeting for Autism Research, Baltimore, MD.", + "Incongruous emotions during fear-eliciting tasks in children with ASD. P. Heymann, S. Macari, A. Milgramm, L. DiNicola, E. Hilton, K. Powell, … and K. Chawarska. (2016). Poster presented at the International Meeting for Autism Research, Baltimore, MD.", + "When do the developmental trajectories of siblings with ASD and BAP diverge from typically developing siblings? E. Hilton, K. Powell, S. Macari, A. Milgramm, P. Heymann, L. DiNicola, … and K. Chawarska. (2016). Poster presented at the International Meeting for Autism Research, Baltimore, MD.", + "Fear reactivity in toddlers with ASD: Diminished response and atypical associations with visual attention. S. Macari, L. DiNicola, G. Greco, F. Shic, L. Flink, S. S. Lansiquot, … and K. Chawarska. (2016). Poster presented at the International Meeting for Autism Research, Baltimore, MD.", + "Examining role of Inhibitory Control in the emotion regulation strategies employed by toddlers with and without ASD . L. DiNicola, S. Macari, L. Flink, S. F. Fontenelle, G. Greco, P. Heymann, … and K. Chawarska. (2016). Poster presented at the International Meeting for Autism Research, Baltimore, MD.", + "Development and validation of harmonized scale of autism symptom severity across ADOS Modules 1 and 2: A BSRC Study . A. Gross, L. Kalb, G. S. Young, E. Stuart, R. Landa, T. K. Charman, K. Chawarska, T. Hutman, D. S. Messinger, S. Ozonoff, W. L. Stone, H. Tager-Flusberg, and L. Zwaigenbaum.. (2016). Talk presented at the International Meeting for Autism Research, Baltimore, MD.", + "The problems with “Look, Don’t Touch”: Designing robots to maximally benefit young children with ASD. L Boccanfuso, L. Chen, C. Torres, B. Hudik, J. C. Snider, M. Sanfilippo, P. E. Ventola, K. Chawarska, J. M. O’Kane, B. Scassellati, and F. Shic. (2016). Poster presented at the International Meeting for Autism Research, Baltimore, MD.", + "Identifying attentional differences in children with and without ASD: A Human-Robot interaction study. E. C. Barney, L. Boccanfuso, C. Foster, C. A. Wall, B. Scassellati, K. Chawarska, and F. Shic (2016). Poster presented at the International Meeting for Autism Research, Baltimore, MD.", + "Human Robot Activity Classification Based on Accelerometer and Gyroscope. B. Li, L. Boccanfuso, Q. Wang, E. Barney, Y. Ahn, C. Foster, K. Chawarska, B. Scassellati, and F. Shic. (2016). Poster to be presented at the IEEE International Symposium on Robot and Human Interactive Communication (RO-MAN).", + "Why High-Risk Families Decline Early Treatment: Barriers to Treating At-Risk Siblings. K. Powell., E. Shoen Simmons, & K. Chawarska. (2015). Poster presented at the International Meeting for Autism Research, Salt Lake City, UT.", + "18-Month Predictors of Later Outcomes in Younger Siblings of Children with Autism Spectrum Disorder: A BSRC Study . K. Chawarska, F. Shic, S. Macari, D. J. Campbell, J. A. Brian, R. J. Landa, … S. E. Bryson, S. E. (2015). Poster presented at the International Meeting for Autism Research, Salt Lake City, UT.", + "A Computational Approach to Eye-Tracking Analysis Reveals Slower Orienting to Movements in Social Scenes in Toddlers with ASD. Q. Wang., S. Macari, K. Chawarska. & F. Shic (2015). Poster presented at the International Meeting for Autism Research, Salt Lake City, UT.", + "Acoustic Properties of Affective Vocalizations Produced by Six-Month-Old High- and Low-Risk Infants. L. DiNicola, E. Schoen Simmons, F. Shic, R. Paul, & K. Chawarska. (2015). Poster presented at the International Meeting for Autism Research, Salt Lake City, UT.", + "Attention and Proximity to Threat Among Toddlers with Autism Spectrum Disorders. G. Greco, S. Macari, L. DiNicola, L. Flink, S. S. Lansiquot, & K. Chawarska. (2015). Poster presented at the International Meeting for Autism Research, Salt Lake City, UT.", + "Attentional Protective Factors in Typically-Developing 6-Month-Old Girls at High-Risk for Autism. F. Shic, S. Macari, & K. Chawarska. (2015). Poster presented at the International Meeting for Autism Research, Salt Lake City, UT.", + "Developmental Plateaus in Gaze Following in 24-Month-Old Toddlers with ASD: An Eye-Tracking Study. L. DiNicola, E. S. Kim, C. A. Wall, G. Greco, S. S. Lansiquot, L., Flink, … Chawarksa, K. (2015). Poster presented at the International Meeting for Autism Research, Salt Lake City, UT.", + "Emotional Reactivity in Toddlers with ASD: Diminished Response to Threatening Stimuli During the Laboratory Temperament Assessment Battery (Lab-TAB). S. Macari, L. DiNicola, A. C. Dowd, L. Flink, E. B. Gisin, G. Greco, …K. Chawarska. (2015). Poster presented at the International Meeting for Autism Research, Salt Lake City, UT.", + "Examining the Structure of Temperament Traits in Toddlers With and Without ASD. C. A. Wall, L. Flink, S. S. Lansiquot, S. H. Kim, F. Shic, J. Koller, K. Chawarska, & S. Macari (2015). Poster presented at the International Meeting for Autism Research, Salt Lake City, UT.", + "Measuring the Importance of FYI Screener Items in Predicting ADOS-T Totals at 12 and 18 Months: A Machine Learning Approach . E. S. Kim, S. H. Kim, S. Macari, K. Chawarska, & F. Shic (2015). Poster presented at the International Meeting for Autism Research, Salt Lake City, UT.", + "Perception of Biological Motion and Integration of Audio-Visual Stimuli in Infants at Risk for Autism. H. S. Reuman, R. Tillman, T. Kim, E. J. Levy, K. Law, A. Naples, … K. Chawarska, & J. McPartland. (2015). Poster presented at the International Meeting for Autism Research, Salt Lake City, UT.", + "Sex Differences Do Not Distinguish High-Risk ASD, High-Risk No ASD, and Low-Risk Children Through Three Years: A BSRC Study . D. S. Messinger, G. S. Young, S. J. Webb, S. Ozonoff, L. Zwaigenbaum, K. Chawarska, … A. S. Carter. (2015). Poster presented at the International Meeting for Autism Research, Salt Lake City, UT.", + "Stability of Temperament in Toddlers with Autism. S. S. Lansiquot, L. Flink, C. A. Wall, S. H. Kim, F. Shic, J. Koller, K. Chawarska, & S. Macari. (2015). Poster presented at the International Meeting for Autism Research, Salt Lake City, UT.", + "Temperamental Features in Toddlers with ASD Are Independent of Symptom Severity. L. Flink, S. S. Lansiquot, C. A. Wall, S. H. Kim, F. Shic, J. Koller, K. Chawarska, & S. Macari. (2015). Poster presented at the International Meeting for Autism Research, Salt Lake City, UT.", + "Promises and Limits: Exploring Relationships Between the First Year Inventory (FYI) and Autism Diagnostic Observation Schedule (ADOS) from 12 to 18 Months of Age with Machine Learning. S. H. Kim, E. S. Kim, S. Macari, K. Chawarska, & F. Shic. (2015). Poster presented at the International Meeting for Autism Research, Salt Lake City, UT.", + "Imitation Abilities in 12-Month-Old Infants at High Risk for Autism Spectrum Disorders (ASD): Parents Provide a Vital Perspective . S. Macari, J. Rowberry, D. J. Campbell, G. Chen, J. Koller, & K. Chawarska. (2015). Poster presented at the International Meeting for Autism Research, Salt Lake City, UT.", + "Attentional Abnormalities During the Prodromal Stage of Autism Spectrum Disorder: Insights from Studies of Infants at High Risk. S. Macari (2014). Talk presented at the Non-Invasive Tools for the Early Detection of Autism Spectrum Disorder Conference, Rome, Italy.", + "Early Diagnosis of Autism Spectrum Disorders: Challenges and Opportunities. K. Chawarska (2014). Plenary address presented at the Association of Southeast Asian Nations Pediatric Federation Congress, Penang, Malaysia.", + "Atypical Social Looking in Early Development in ASD: Computational Views and the Clinical Potential. F. Shic (2014). Talk presented at National Yang-Ming University Psychology Department, Taipei, Taiwan.", + "Early Atypical Growth Patterns in ASD: Evidence from Behavioral, Neuroimaging, and Neurobiological Studies. K. Chawarska (2014). Scientific symposium presented at the International Meeting for Autism Research, Atlanta, GA.", + "Correspondence Between Parent Report and Clinician Observation at 12 Months in Infants at High Risk for ASD. S. Macari, D.J. Campbell, G. Chen, J. Koller, and K. Chawarska (2014). Talk presented at the International Meeting for Autism Research, Atlanta, GA.", + "High-Risk Siblings with Atypical Developmental Trajectories: Clinical Outcomes at Early School Age. K.D. Tsatsanis, K.K. Powell, and K. Chawarska (2014). Poster presented at the International Meeting for Autism Research, Atlanta, GA.", + "Interest in Potential Reinforcers in the Second Year of Life Predicts Outcome of Behavioral Intervention in Toddlers with ASD. L. Klintwall, S. Macari, S. Eikeseth, and K. Chawarska (2014). Poster presented at the International Meeting for Autism Research, Atlanta, GA.", + "Parsing Heterogeneity of Early ASD Phenotype: Stability and Change. S.H. Kim, S. Macari, C. Saulnier, A. Steiner, T. Goldsmith, J. Koller, K.D. Tsatsanis, and K. Chawarska (2014). Poster presented at the International Meeting for Autism Research, Atlanta, GA.", + "The Utility of the First Year Inventory in Evaluating Autism Symptoms at 12 Months in Infants at High Risk for ASD. S. Macari, J. Rowberry, D.J. Campbell, and K. Chawarska (2014). Poster presented at the International Meeting for Autism Research, Atlanta, GA.", + "The Relationship Between Autism Symptoms and Arousal Level in Toddlers with ASD, as Measured By Electrodermal Activity. E. Prince, E. Gisin, C. Wall, K. Chawarska, and F. Shic (2014). Poster presented at the International Meeting for Autism Research, Atlanta, GA.", + "Components of Limited Activity Monitoring in Toddlers and Children with ASD. F. Shic, G. Chen, M. Perlmutter, E.B. Gisin, A. Dowd, E.B. Prince, L. Flink, S. Lansiquot, C.A. Wall, E. Kim, Q. Wang, S. Macari, and K. Chawarska (2014). Poster presented at the International Meeting for Autism Research, Atlanta, GA.", + "Dimensionality of Gaze Patterns Towards Faces and Objects in Toddlers with ASD. Q. Wang, K. Chawarska, S. Zucker, B. Scassellati, and F. Shic (2014). Poster presented at the International Meeting for Autism Research, Atlanta, GA.", + "Predicting Clinical Phenotype from Activity Monitoring Gaze Patterns in Children with ASD. F. Shic, S. Macari, and K. Chawarska (2014). Poster presented at the Translation Science 2014 Annual Meeting, Washington, D.C.", + "Decreased Social Attention in 6-Month-Old Infants Later Diagnosed with ASD. K. Chawarska, S. Macari, J.D. Campbell, S.H. Kim, A. Dowd, K. O'Loughlin, J. Garzarek, G.M. Chen, E.B. Gisin, and F. Shic (2013). Talk presented at the International Meeting for Autism Research, San Sebastian, Spain.", + "Atypical Social Attention Patterns in 6-Month-Old Infants Later Diagnosed with ASD During a Face to Face Dyadic Interaction. S.H. Kim, S. Macari, F. Shic, A. Dowd, K. O'Loughlin, J. Garzarek, G.M. Chen, E.B. Gisin, and K. Chawarska (2013). Talk presented at the International Meeting for Autism Research, San Sebastian, Spain.", + "Emergence of Social Deficits During the Second Year of Life in Infants with ASD. A. Dowd, E. Prince, E.B. Gisin, S.H. Kim, S. Macari, and K. Chawarska (2013). Poster presented at the International Meeting for Autism Research, San Sebastian, Spain.", + "Association of Early Generalized Overgrowth to Clinical Outcome in ASD. D.J. Campbell, J. Chang, and K. Chawarska (2013). Poster presented at the International Meeting for Autism Research, San Sebastian, Spain.", + "Social Perception in Toddlers With Autism Spectrum Disorder. K. Chawarska (2013). Symposium presented at the Society for Research in Child Development, Seattle, WA. Limited orienting to social cues in infants and toddlers with ASD (K. Chawarska, S. Macari, J.D. Campbell, and F. Shic) Diminished social salience, not enhanced perceptual salience in toddlers with ASD (D. Campbell, F. Shic, S. Macari, J. Chang, and K. Chawarska) Subtyping gaze patterns in response to dyadic bids for attention. (S. Macari, F. Shic, D. Campbell, and K. Chawarska) Operationalizing Atypical: Attentional Cohesion by Toddlers with ASD. (F. Shic, D. Campbell, S. Macari, and K. Chawarska)", + "Limited orienting to social cues in infants and toddlers with ASD (K. Chawarska, S. Macari, J.D. Campbell, and F. Shic)", + "Diminished social salience, not enhanced perceptual salience in toddlers with ASD (D. Campbell, F. Shic, S. Macari, J. Chang, and K. Chawarska)", + "Subtyping gaze patterns in response to dyadic bids for attention. (S. Macari, F. Shic, D. Campbell, and K. Chawarska)", + "Operationalizing Atypical: Attentional Cohesion by Toddlers with ASD. (F. Shic, D. Campbell, S. Macari, and K. Chawarska)", + "Hierarchical clustering of face scanning in 6-month-old infants at high risk for ASD reveals associations with social deficits at 24 months. F. Shic, D. Campbell, S. Macari, and K. Chawarska (2013). Talk presented at the Society for Research in Child Development, Seattle, WA.", + "Profiles of Adaptive Socialization Skills in Children with ASD in the First Two Years of Life. C. Saulnier, K. Caravella, A. Klin, and K. Chawarska (2013). Poster presented at the Society for Research in Child Development, Seattle, WA.", + "Yale study: Children with autistic sibling may develop emotional difficulties . News12, April 2022.", + "Championing Autism Awareness . The Tom Ficklin Show, April 4, 2022.", + "How Puppets Can Be Used in Autism Therapeutics . Autism Advocate Parenting Magazine, April 2022", + "Researcher connections: Understanding a decade of collaborations in autism research. Spectrum, June 12, 2020", + "Infants’ attention to faces may predict autism before formal diagnosis . Spectrum, March 20, 2020.", + "In autism, the social benefits of being a girl. Yale News, 2016. February 8.", + "Girls at risk for autism more likely to respond to facial cues. Yale Daily News, 2016, February 16.", + "Sharp observation skills may guard girls against severe autism. Simons Foundation Spectrum News, 2016, February 1.", + "In autism, there are social benefits of being a girl. Science Daily. 2016, February 8.", + "Girls at risk for autism pay more attention to social cues. Neuroscience News. 2016, February 9.", + "Girls at risk for autism are more attuned to social cues than boys. Greenwich Time, 2016, February 9.", + "Autism news and updates: Girls with autism deal easier with their condition. Parent Herald. 2016, February 10.", + "Baby girls with and autistic sibling pay more attention to social cues which may protect them from the disorder. Medicine Daily, 2016 February 10.", + "In autism, the social benefits of being a girl. EurekaAlert, 2016, February 9.", + "Making ‘miniature brains’ from skin cells to better understand autism. Yale News, 2015, July 20.", + "Early diagnosis and intervention key with autism improvement. Chicago Tribune: 2015, March 20.", + "Interest level may serve as a predictor in autistic children . Yale Daily News, December 2014.", + "Certain behaviors may predict autism in high-risk children . International Center for Autism Research and Education, November 2014.", + "Behavioral patterns may predict autism in high-risk toddlers . Simons Foundation Autism Research Initiative. November, 2014.", + "Studies question link between head circumference, autism . Simons Foundation Autism Research Initiative. October, 2014.", + "Siblings of children with autism can show signs at 18 months . Medical Xpress. October, 2014.", + "Siblings of autistic children have 20% chance of developing disorder . New Haven Register. October, 2014.", + "Siblings of children with autism can show signs at 18 months . Yale News. October, 2014.", + "Autism may be predicted by overgrowth . Yale Daily News. September, 2014.", + "Zeroing in on illusions in eye-gaze research . Simons Foundation Autism Research Initiative. May, 2014.", + "Autism and infant attention explored . Yale Daily News. January, 2014.", + "A child's focus: Breakthroughs in early autism detection in infants . Yale Scientific. May, 2013.", + "Cognition and behavior: Attention early indicator of autism . Simons Foundation Autism Research Initiative. March, 2013.", + "Autism symptoms identified in 6-month-old infants . Yale Daily News. February, 2013.", + "Attention deficits discovered in babies who later develop autism . SciTechDaily. February, 2013.", + "RAS pathway, a potentially unifying theory of autism . Simons Foundation Autism Research Initiative. March, 2012.", + "Clinical research: Toddlers with autism larger than peers . Simons Foundation Autism Research Initiative. November, 2011.", + "Autism in Infancy and Early Childhood. K. Chawarska, S. Macari, F. Volkmar, S. H. Kim, & F. Shic (2014). In F. Volkmar, S. Rogers, R. Paul, & K. Pelphrey (Eds.), Handbook of Autism and Pervasive Developmental Disorders. Hoboken, NJ: John Wiley & Sons. (In Press.)", + "Avaliacao clinica de criancas com risco de autism. A. Klin, K. Chawarska, E. Rubin, & F. Volkmar (2013). In C. D. Stobäus & J. J. M. Mosquera (Eds.), Educação e Inclusão: Perspectivas desafiadoras. Porto Alegre, Brazil: EdiPUC.", + "Future Directions in ASD Research. D. Fein, K. Chawarska, & I. Rapin (2011). In D. Fein (Ed.), The Neuropsychology of Autism (pp. 511-526). New York, NY: Oxford University Press.", + "Autism Spectrum Disorders in Infants and Toddlers. K. Chawarska, A. Klin, & F. Volkmar (Eds.) (2010). New York, NY: Guilford Press. Japanese translation.", + "Autism Spectrum Disorders in Infants and Toddlers. K. Chawarska, A. Klin, & F. Volkmar (Eds.) (2008). New York, NY: Guilford Press.", + "300 George Street New Haven, CT 06520-8023 Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Chen Lab", + "lab_url": "https://medicine.yale.edu/lab/chen/", + "research_bio": "INFORMATION FOR Copy Link Principal Investigator United Technologies Corporation Professor in Cancer Research and Professor of Immunobiology, of Dermatology and of Medicine (Medical Oncology) Copy Link Copy Link Senior Research Scientist; Project and Lab Manager , Yale School of Medicine Copy Link If you are interested in a Postdoctoral position in Lieping Chen’s lab, please provide the following: Please send your inquiry to Dr. Chen atLieping.Chen@yale.eduandAla.Nassar@yale.edu. If you are interested in being part of our Immunobiology Graduate Program, please contactgraduate.admissions@yale.eduor visit theYale Immunobiology Website. Copy Link If you are interested in a Postdoctoral position in Lieping Chen’s lab, please provide the following: Please send your inquiry to Dr. Chen atLieping.Chen@yale.eduandAla.Nassar@yale.edu. If you are interested in being part of our Immunobiology Graduate Program, please contactgraduate.admissions@yale.eduor visit theYale Immunobiology Website. Copy Link Edward Quinlan, PhDSenior Research ScientistOmnicyte Inc.Wallingford, CT Miguel F. Sanmamed, MD, PhDAssistant ProfessorDepartment of Medicine -Medical OncologyUniversity of NavarraPamplona, Spain Agedi N. Boto, MD, PhDStaff PathologistFairfield County Pathology ConsultantsFairfield, CT Tae Kon Kim, MD, PhDAssistant ProfessorDepartment of Medicine -Hematology/OncologyVanderbilt University School of MedicineNashville, TN Jun Wang, PhDAssistant ProfessorDepartment of PathologyNew York University Grossman School of MedicineNew York, NY Jingwei Sun, PhDScientistIntellia Therapeutics, IncCambridge, MA Jingdong Zhang, PhDScientistTcelltech Inc.Fuzhou, China Matthew D. Vesely, MD, PhDAssistant ProfessorDepartment of DermatologyYale School of MedicineNew Haven, CT Xue Han, PhDAssistant ProfessorDepartment of Microbial Infections & ImmunityThe Ohio State University College of MedicineColumbus, OH Linghua Zheng, PhDAssistant ProfessorDepartment of Medicine (Medical Oncology)The Ohio State University College of MedicineColumbus, OH Runxia Gu, MD, PhDAssociate ProfessorInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical SciencesTianjin, China Jacky Yeung, MD, PhDAssistant ProfessorDepartment of NeurosurgeryYale School of MedicineNew Haven, CT", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Chen Liu Lab", + "lab_url": "https://medicine.yale.edu/lab/chen-liu/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/chen-liu/publications/", + "publications": [ + "Yale School of Medicine /", + "Pathology /", + "Research", + "Contact", + "People", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "News", + "Contact", + "", + "", + "", + "", + "", + "", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Child Wellbeing and Education Research", + "lab_url": "https://medicine.yale.edu/lab/strambler/", + "research_bio": "INFORMATION FOR Copy Link We conduct applied research on factors that are linked to outcomes around the academic, social, behavioral, and psychological wellbeing of children and youth. We primarily draw on theory and methods from the fields of psychology, education, and interdisciplinary areas such as human development, implementation science, translational science, and program evaluation. What we mean by applied is that our work focuses on addressing practical problems by putting existing evidence and theory into practice. We aim to understand how these applications improve conditions and outcomes for children and families. This kind of applied research differs from basic research, which focuses more on advancing scientific knowledge in areas that researchers and the public are curious about. While in theory, these types of research are distinct, in practice, they often overlap, which is the case with our work. While we have a strong leaning towards the applied end of research, we believe that basic research is also essential for addressing gaps in our knowledge and building a larger base for applied research to draw upon. In short, we aim to produce work that bridges the goals of applied and basic research that produces useable and actionable evidence. Our team's guiding principles involve conducting research that is honest, rigorous, and useful. Honest. Doing honest research means engaging in a search for answers to questions and allowing for our conclusions to be driven by evidence rather than our individual opinions, desires, and ideologies. This does not mean that we approach the work free of personal values. On the contrary, we have strong opinions and deeply care about solving social problems. However, to solve such problems, we believe that an accurate understanding of their nature and effective means of addressing them is essential, and achieving this means removing as many of our biases as possible. Sometimes we will encounter research findings that run counter to what we hypothesize or contradict our held views. We must be open to revising our thinking in light of such findings rather than seeking ways to fit the findings into our preexisting beliefs. In other words, we believe we should never set out to “prove” anything. Rather, we should aim to produce the best evidence possible for answering our questions and see where the evidence takes us. Rigorous. What we mean by being rigorous is using the best practices in research methodology to address questions given the project's feasibility constraints. These approaches can range from descriptive research to randomized controlled trials and may involve quantitative, qualitative, and/or mixed-methods techniques. Doing this requires staying on top of rapidly developing methodological and statistical techniques and consulting with others with more expertise in these areas than us. Useful. Given the applied nature of our work, we aim to make it useful and actionable for those who are most likely to benefit from it, namely practitioners, policymakers, and laypeople. To achieve this goal, research collaboration is regularly an important aspect of how we go about our work. Practitioner and policymaker partners often bring critical insights and expertise regarding the contextual factors associated with the phenomena under study and valuable information about constraints of the research setting that may limit the type of research and/or interventions that can be implemented. Because of these insights, in addition to helping make research more useable, collaboration adds to our scientific knowledge. Making research useful also means considering how it is disseminated. To make research useful, our dissemination approach involves a range of products, including peer-reviewed research, research reports, and public-facing pieces such as media editorials. Copy Link Director Associate Professor of Psychiatry; Director, Child Wellbeing and Education Research Assistant Director Assistant Director of Child Wellbeing and Education Research", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Cho Lab", + "lab_url": "https://medicine.yale.edu/lab/cho/", + "research_bio": "INFORMATION FOR The Cho Lab focuses on the development of cognitive, emotional and motivational brain circuits in adolescents with depression and adolescents with schizophrenia using fMRI. Adolescence is a time of significant physical, socio-emotional and intellectual growth. It is also a time when many psychiatric illnesses begin to emerge. We are interested in understanding the neurobiological vulnerabilities that can lead to developing depression, schizophrenia and other illnesses. The Cho Lab also uses pharmacologic neuroimaging to identify mechanisms of potential treatments. By identifying how pharmacology affects brain circuits, we can better decide whether this pharmacologic approach is well-suited or not for a particular symptom. The lab’s work is funded by the NIMH, the Brain and Behavior Research Foundation, and the Yale School of Medicine. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/cho/publications/", + "publications": [ + "Yale School of Medicine /", + "Child Study Center /", + "Research", + "Participate", + "Lab Members", + "Collaborators", + "Publications", + "Positions", + "News", + "Photo Gallery", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Lab Members", + "Publications", + "News", + "Participate", + "Collaborators", + "Positions", + "Photo Gallery", + "", + "", + "", + "", + "", + "", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Chun Lab", + "lab_url": "https://medicine.yale.edu/lab/chun/", + "research_bio": "INFORMATION FOR Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/chun/publications/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Cardiovascular Medicine /", + "Projects", + "Funding", + "Publications", + "News", + "People", + "Contact", + "Photos Hyekyung Farewell Party, July 2013 Yujung Farewell Lunch, April 2013 Jongmin Farewell Party, March 2013 Chun Lab Holiday Party, January 2013", + "Hyekyung Farewell Party, July 2013", + "Yujung Farewell Lunch, April 2013", + "Jongmin Farewell Party, March 2013", + "Chun Lab Holiday Party, January 2013", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Projects", + "Publications", + "People", + "Photos", + "Funding", + "News", + "Contact", + "", + "", + "", + "", + "", + "", + "Dual-function robotic gripper for traction and closure in gastric endoscopic submucosal dissection: an in vivo porcine model study (with video). Kim SH, Seo YC, Keum B, Jeon HJ, Lee JM, Choi HS, Kim ES, Jeen YT, Lee HS, Hwang JH, Chun HJ. Surg Endosc. 2025 Nov; 2025 Sep 18. PMID: 40968213.", + "Ergonomic impact of an automated device for endoscopic tool insertion and transfer (with video). Kim SH, Choi HS, Lee BM, Jeon HJ, Lee JM, Kim ES, Keum B, Jeen YT, Lee HS, Kim BR, Hwang JH, Chun HJ. Gastrointest Endosc. 2025 Sep; 2025 Feb 7. PMID: 39924059.", + "The Somatic Mosaicism across Human Tissues Network. Coorens THH, Oh JW, Choi YA, Lim NS, Zhao B, Voshall A, Abyzov A, Antonacci-Fulton L, Aparicio S, Ardlie KG, Bell TJ, Bennett JT, Bernstein BE, Blanchard TG, Boyle AP, Buenrostro JD, Burns KH, Chen F, Chen R, Choudhury S, Doddapaneni HV, Eichler EE, Evrony GD, Faith MA, Fazzio TG, Fulton RS, Garber M, Gehlenborg N, Germer S, Getz G, Gibbs RA, Hernandez RG, Jin F, Korbel JO, Landau DA, Lawson HA, Lennon NJ, Li H, Li Y, Loh PR, Marth G, McConnell MJ, Mills RE, Montgomery SB, Natarajan P, Park PJ, Satija R, Sedlazeck FJ, Shao DD, Shen H, Stergachis AB, Underhill HR, Urban AE, VonDran MW, Walsh CA, Wang T, Wu TP, Zong C, Lee EA, Vaccarino FM. Nature. 2025 Jul; 2025 Jul 2. PMID: 40604182.", + "Novel robotic gripper for traction and closure in colorectal endoscopic submucosal dissection. Kim SH, Choi HS, Jeon HJ, Kim ES, Keum B, Jeen YT, Ahn S, Hwang JH, Chun HJ. VideoGIE. 2025 Mar; 2024 Dec 26. PMID: 40093298.", + "A Novel Retractable Robotic Device for Colorectal Endoscopic Submucosal Dissection. Kim SH, Kim C, Keum B, Im J, Won S, Kim BG, Kim K, Kwon T, Hong D, Jeon HJ, Choi HS, Kim ES, Jeen YT, Chun HJ, Hwang JH. Gut Liver. 2024 Jul 15; 2024 May 7. PMID: 38712393.", + "Robot-assisted gastric endoscopic submucosal dissection significantly improves procedure time at challenging dissection locations. Kim SH, Kwon T, Choi HS, Kim C, Won S, Jeon HJ, Kim ES, Keum B, Jeen YT, Hwang JH, Chun HJ. Surg Endosc. 2024 Apr; 2024 Mar 11. PMID: 38467861.", + "BMPR1A promotes ID2-ZEB1 interaction to suppress excessive endothelial to mesenchymal transition. Lee HW, Adachi T, Pak B, Park S, Hu X, Choi W, Kowalski PS, Chang CH, Clapham KR, Lee A, Papangeli I, Kim J, Han O, Park J, Anderson DG, Simons M, Jin SW, Chun HJ. Cardiovasc Res. 2023 May 2. PMID: 36166408.", + "Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS-CoV-2 infection (PASC) syndrome. Singh I, Leitner BP, Wang Y, Zhang H, Joseph P, Lutchmansingh DD, Gulati M, Possick JD, Damsky W, Hwa J, Heerdt PM, Chun HJ. Pulm Circ. 2023 Apr; 2023 Apr 1. PMID: 37091121.", + "LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis. Peng T, Liu M, Hu L, Guo D, Wang D, Qi B, Ren G, Hu C, Zhang F, Chun HJ, Song L, Hu J, Li Y. Biol Direct. 2022 Nov 16; 2022 Nov 16. PMID: 36384975.", + "Endothelial β-arrestins regulate mechanotransduction by the type II bone morphogenetic protein receptor in primary cilia. Park S, Ma Z, Zarkada G, Papangeli I, Paluri S, Nazo N, Rivera-Molina F, Toomre D, Rajagopal S, Chun HJ. Pulm Circ. 2022 Oct; 2022 Oct 1. PMID: 36532314.", + "Association of renalase with clinical outcomes in hospitalized patients with COVID-19. Safdar B, Wang M, Guo X, Cha C, Chun HJ, Deng Y, Dziura J, El-Khoury JM, Gorelick F, Ko AI, Lee AI, Safirstein R, Simonov M, Zhou B, Desir GV. PLoS One. 2022; 2022 Mar 8. PMID: 35259186.", + "Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-A. Mantsounga CS, Lee C, Neverson J, Sharma S, Healy A, Berus JM, Parry C, Ceneri NM, López-Giráldez F, Chun HJ, Lu Q, Sellke F, Choudhary G, Morrison AR. Cell Rep. 2022 Feb 1. PMID: 35108537.", + "Severe breakthrough COVID-19 cases in the SARS-CoV-2 delta (B.1.617.2) variant era. Wang SY, Juthani PV, Borges KA, Shallow MK, Gupta A, Price C, Won CH, Chun HJ. Lancet Microbe. 2022 Jan; 2021 Dec 3. PMID: 34901896.", + "Hospitalisation among vaccine breakthrough COVID-19 infections. Juthani PV, Gupta A, Borges KA, Price CC, Lee AI, Won CH, Chun HJ. Lancet Infect Dis. 2021 Nov; 2021 Sep 7. PMID: 34506735.", + "Association of obesity with venous thromboembolism and myocardial injury in COVID-19. Wang SY, Singh A, Eder MD, Vadlamani L, Lee AI, Chun HJ, Desai NR. Obes Res Clin Pract. 2021 Sep-Oct; 2021 Jul 16. PMID: 34281793.", + "Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy. McConnell MJ, Kawaguchi N, Kondo R, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Lee AI, Pine AB, Chun HJ, Zhang X, Fernandez-Hernando C, Qing H, Wang A, Price C, Sun Z, Utsumi T, Hwa J, Strazzabosco M, Iwakiri Y. J Hepatol. 2021 Sep; 2021 May 13. PMID: 33991637.", + "Chronic Thromboembolic Pulmonary Hypertension: the Bedside. Matusov Y, Singh I, Yu YR, Chun HJ, Maron BA, Tapson VF, Lewis MI, Rajagopal S. Curr Cardiol Rep. 2021 Aug 19; 2021 Aug 19. PMID: 34410530.", + "Chronic Thromboembolic Pulmonary Hypertension: the Bench. Alba GA, Atri D, Darbha S, Singh I, Tapson VF, Lewis MI, Chun HJ, Yu YR, Maron BA, Rajagopal S. Curr Cardiol Rep. 2021 Aug 19; 2021 Aug 19. PMID: 34410515.", + "Challenges in interpreting cytokine data in COVID-19 affect patient care and management. Wang SY, Takahashi T, Pine AB, Damsky WE, Simonov M, Zhang Y, Kieras E, Price CC, King BA, Siegel MD, Desir GV, Lee AI, Iwasaki A, Chun HJ. PLoS Biol. 2021 Aug; 2021 Aug 6. PMID: 34358229.", + "Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection. Chun HJ, Coutavas E, Pine AB, Lee AI, Yu VL, Shallow MK, Giovacchini CX, Mathews AM, Stephenson B, Que LG, Lee PJ, Kraft BD. JCI Insight. 2021 Jul 22; 2021 Jul 22. PMID: 34111030.", + "Author Correction: Delayed production of neutralizing antibodies correlates with fatal COVID-19. Lucas C, Klein J, Sundaram ME, Liu F, Wong P, Silva J, Mao T, Oh JE, Mohanty S, Huang J, Tokuyama M, Lu P, Venkataraman A, Park A, Israelow B, Vogels CBF, Muenker MC, Chang CH, Casanovas-Massana A, Moore AJ, Zell J, Fournier JB, Wyllie AL, Campbell M, Lee AI, Chun HJ, Grubaugh ND, Schulz WL, Farhadian S, Dela Cruz C, Ring AM, Shaw AC, Wisnewski AV, Yildirim I, Ko AI, Omer SB, Iwasaki A. Nat Med. 2021 Jul. PMID: 34145437.", + "Delayed production of neutralizing antibodies correlates with fatal COVID-19. Lucas C, Klein J, Sundaram ME, Liu F, Wong P, Silva J, Mao T, Oh JE, Mohanty S, Huang J, Tokuyama M, Lu P, Venkataraman A, Park A, Israelow B, Vogels CBF, Muenker MC, Chang CH, Casanovas-Massana A, Moore AJ, Zell J, Fournier JB, Wyllie AL, Campbell M, Lee AI, Chun HJ, Grubaugh ND, Schulz WL, Farhadian S, Dela Cruz C, Ring AM, Shaw AC, Wisnewski AV, Yildirim I, Ko AI, Omer SB, Iwasaki A. Nat Med. 2021 Jul; 2021 May 5. PMID: 33953384.", + "Interleukin-1- Receptor Kinase 4 Inhibition: Achieving Immunomodulatory Synergy to Mitigate the Impact of COVID-19. Gupta A, Chun HJ. Front Immunol. 2021; 2021 Jun 23. PMID: 34248990.", + "Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection. Ma L, Sahu SK, Cano M, Kuppuswamy V, Bajwa J, McPhatter J, Pine A, Meizlish ML, Goshua G, Chang CH, Zhang H, Price C, Bahel P, Rinder H, Lei T, Day A, Reynolds D, Wu X, Schriefer R, Rauseo AM, Goss CW, O’Halloran JA, Presti RM, Kim AH, Gelman AE, Dela Cruz CS, Lee AI, Mudd PA, Chun HJ, Atkinson JP, Kulkarni HS. Sci Immunol. 2021 May 13. PMID: 34446527.", + "Immuno-fibrotic drivers of impaired lung function in post-acute sequelae of SARS-CoV-2 infection (PASC). Chun HJ, Coutavas E, Pine A, Lee AI, Yu V, Shallow M, Giovacchini CX, Mathews A, Stephenson B, Que LG, Lee PJ, Kraft BD. medRxiv. 2021 Apr 21; 2021 Apr 21. PMID: 33564789.", + "Intermediate-dose anticoagulation, aspirin, and in-hospital mortality in COVID-19: A propensity score-matched analysis. Meizlish ML, Goshua G, Liu Y, Fine R, Amin K, Chang E, DeFilippo N, Keating C, Liu Y, Mankbadi M, McManus D, Wang SY, Price C, Bona RD, Ochoa Chaar CI, Chun HJ, Pine AB, Rinder HM, Siner JM, Neuberg DS, Owusu KA, Lee AI. Am J Hematol. 2021 Apr 1; 2021 Feb 22. PMID: 33476420.", + "A neutrophil activation signature predicts critical illness and mortality in COVID-19. Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun HJ. Blood Adv. 2021 Mar 9. PMID: 33635335.", + "Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation. Gu SX, Tyagi T, Jain K, Gu VW, Lee SH, Hwa JM, Kwan JM, Krause DS, Lee AI, Halene S, Martin KA, Chun HJ, Hwa J. Nat Rev Cardiol. 2021 Mar; 2020 Nov 19. PMID: 33214651.", + "Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection. Ma L, Sahu SK, Cano M, Kuppuswamy V, Bajwa J, McPhatter J, Pine A, Meizlish M, Goshua G, Chang CH, Zhang H, Price C, Bahel P, Rinder H, Lei T, Day A, Reynolds D, Wu X, Schriefer R, Rauseo AM, Goss CW, O'Halloran JA, Presti RM, Kim AH, Gelman AE, Cruz CD, Lee AI, Mudd P, Chun HJ, Atkinson JP, Kulkarni HS. bioRxiv. 2021 Feb 23; 2021 Feb 23. PMID: 33655244.", + "Collateral Damage: Gun Violence-Induced STEMI. Shah NN, Kay B, Jiang NM, Chun HJ. JACC Case Rep. 2021 Jan; 2021 Jan 20. PMID: 34317462.", + "Intermediate-dose anticoagulation, aspirin, and in-hospital mortality in COVID-19: a propensity score-matched analysis. Meizlish ML, Goshua G, Liu Y, Fine R, Amin K, Chang E, DeFilippo N, Keating C, Liu Y, Mankbadi M, McManus D, Wang S, Price C, Bona RD, Chaar CIO, Chun HJ, Pine AB, Rinder HM, Siner J, Neuberg DS, Owusu KA, Lee AI. medRxiv. 2021 Jan 15; 2021 Jan 15. PMID: 33469595.", + "Changes in inflammatory and immune drivers in response to immunomodulatory therapies in COVID-19. Wang SY, Chang CH, Meizlish ML, Bahel P, Rinder HM, Lee AI, Chun HJ. medRxiv. 2020 Dec 25; 2020 Dec 25. PMID: 33398292.", + "Circulating markers of angiogenesis and endotheliopathy in COVID-19. Pine AB, Meizlish ML, Goshua G, Chang CH, Zhang H, Bishai J, Bahel P, Patel A, Gbyli R, Kwan JM, Won CH, Price C, Dela Cruz CS, Halene S, van Dijk D, Hwa J, Lee AI, Chun HJ. Pulm Circ. 2020 Oct-Dec; 2020 Nov 25. PMID: 33282193.", + "Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Lancet Haematol. 2020 Aug; 2020 Jun 30. PMID: 32619411.", + "Circulating Markers of Angiogenesis and Endotheliopathy in COVID-19. Meizlish ML, Pine AB, Goshua G, Chang CH, Zhang H, Bishai J, Bahel P, Patel A, Gbyli R, Kwan J, Price C, Cruz CSD, Halene S, van Dijk D, Hwa J, Lee AI, Chun HJ. medRxiv. 2020 Jul 1; 2020 Jul 1. PMID: 32637968.", + "The apelinergic system: a perspective on challenges and opportunities in cardiovascular and metabolic disorders. Marsault E, Llorens-Cortes C, Iturrioz X, Chun HJ, Lesur O, Oudit GY, Auger-Messier M. Ann N Y Acad Sci. 2019 Nov; 2019 Jun 25. PMID: 31236974.", + "MEF2 and the Right Ventricle: From Development to Disease. Clapham KR, Singh I, Capuano IS, Rajagopal S, Chun HJ. Front Cardiovasc Med. 2019; 2019 Mar 28. PMID: 30984767.", + "Therapeutic Engagement of the Histone Deacetylase IIA-Myocyte Enhancer Factor 2 Axis Improves Experimental Pulmonary Hypertension. Sofer A, Lee S, Papangeli I, Adachi T, Hwangbo C, Comhair S, DaSilva-Jardine P, Kim J, Schwarz JJ, Erzurum SC, Chun HJ. Am J Respir Crit Care Med. 2018 Nov 15. PMID: 30106596.", + "A Tale of Two Elabela Null Mice. Papangeli I, Chun HJ. Trends Endocrinol Metab. 2017 Nov; 2017 Sep 27. PMID: 28964631.", + "Reply: Transforming Growth Factor β1- and Bone Morphogenetic Protein 2/PPARγ-regulated MicroRNAs in Pulmonary Arterial Hypertension. Chun HJ, Bonnet S, Chan SY. Am J Respir Crit Care Med. 2017 Nov 1. PMID: 28653904.", + "Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects. Hwangbo C, Wu J, Papangeli I, Adachi T, Sharma B, Park S, Zhao L, Ju H, Go GW, Cui G, Inayathullah M, Job JK, Rajadas J, Kwei SL, Li MO, Morrison AR, Quertermous T, Mani A, Red-Horse K, Chun HJ. Sci Transl Med. 2017 Sep 13. PMID: 28904225.", + "Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report. Newman JH, Rich S, Abman SH, Alexander JH, Barnard J, Beck GJ, Benza RL, Bull TM, Chan SY, Chun HJ, Doogan D, Dupuis J, Erzurum SC, Frantz RP, Geraci M, Gillies H, Gladwin M, Gray MP, Hemnes AR, Herbst RS, Hernandez AF, Hill NS, Horn EM, Hunter K, Jing ZC, Johns R, Kaul S, Kawut SM, Lahm T, Leopold JA, Lewis GD, Mathai SC, McLaughlin VV, Michelakis ED, Nathan SD, Nichols W, Page G, Rabinovitch M, Rich J, Rischard F, Rounds S, Shah SJ, Tapson VF, Lowy N, Stockbridge N, Weinmann G, Xiao L. Am J Respir Crit Care Med. 2017 Jun 15. PMID: 28430547.", + "Modulation of Endothelial Bone Morphogenetic Protein Receptor Type 2 Activity by Vascular Endothelial Growth Factor Receptor 3 in Pulmonary Arterial Hypertension. Hwangbo C, Lee HW, Kang H, Ju H, Wiley DS, Papangeli I, Han J, Kim JD, Dunworth WP, Hu X, Lee S, El-Hely O, Sofer A, Pak B, Peterson L, Comhair S, Hwang EM, Park JY, Thomas JL, Bautch VL, Erzurum SC, Chun HJ, Jin SW. Circulation. 2017 Jun 6; 2017 Mar 29. PMID: 28356442.", + "A PPARγ-dependent miR-424/503-CD40 axis regulates inflammation mediated angiogenesis. Lee A, Papangeli I, Park Y, Jeong HN, Choi J, Kang H, Jo HN, Kim J, Chun HJ. Sci Rep. 2017 May 31; 2017 May 31. PMID: 28566713.", + "Relative predictive value of lung cancer screening CT versus myocardial perfusion attenuation correction CT in the evaluation of coronary calcium. Bailey G, Healy A, Young BD, Sharma E, Meadows J, Chun HJ, Wu WC, Choudhary G, Morrison AR. PLoS One. 2017; 2017 Apr 24. PMID: 28437443.", + "Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production. Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi MM, Bender JR, Morrison AR. Arterioscler Thromb Vasc Biol. 2017 Feb; 2016 Nov 10. PMID: 27834690.", + "Translational Advances in the Field of Pulmonary Hypertension. Translating MicroRNA Biology in Pulmonary Hypertension. It Will Take More Than \"miR\" Words. Chun HJ, Bonnet S, Chan SY. Am J Respir Crit Care Med. 2017 Jan 15. PMID: 27648944.", + "MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation. Papangeli I, Kim J, Maier I, Park S, Lee A, Kang Y, Tanaka K, Khan OF, Ju H, Kojima Y, Red-Horse K, Anderson DG, Siekmann AF, Chun HJ. Nat Commun. 2016 Apr 12; 2016 Apr 12. PMID: 27068353.", + "miR-182 Modulates Myocardial Hypertrophic Response Induced by Angiogenesis in Heart. Li N, Hwangbo C, Jaba IM, Zhang J, Papangeli I, Han J, Mikush N, Larrivée B, Eichmann A, Chun HJ, Young LH, Tirziu D. Sci Rep. 2016 Feb 18; 2016 Feb 18. PMID: 26888314.", + "Letter by Papangeli et al Regarding Article, \"The ERG-APLNR Axis Controls Pulmonary Venule Endothelial Proliferation in Pulmonary Veno-Occlusive Disease\". Papangeli I, Sharma B, Chun HJ. Circulation. 2015 Jul 14. PMID: 26169651.", + "Elafin in pulmonary arterial hypertension. Beyond targeting elastases. Chun HJ, Yu PB. Am J Respir Crit Care Med. 2015 Jun 1. PMID: 26029832.", + "Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension. Kim J, Hwangbo C, Hu X, Kang Y, Papangeli I, Mehrotra D, Park H, Ju H, McLean DL, Comhair SA, Erzurum SC, Chun HJ. Circulation. 2015 Jan 13; 2014 Oct 21. PMID: 25336633.", + "Endothelium as a gatekeeper of fatty acid transport. Mehrotra D, Wu J, Papangeli I, Chun HJ. Trends Endocrinol Metab. 2014 Feb; 2013 Dec 3. PMID: 24315207.", + "Essential role of Apelin signaling during lymphatic development in zebrafish. Kim JD, Kang Y, Kim J, Papangeli I, Kang H, Wu J, Park H, Nadelmann E, Rockson SG, Chun HJ, Jin SW. Arterioscler Thromb Vasc Biol. 2014 Feb; 2013 Dec 5. PMID: 24311379.", + "Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development. Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ. Circ Res. 2013 Jun 21; 2013 Apr 19. PMID: 23603510.", + "Severe obstructive sleep apnea increases mortality in patients with ischemic heart disease and myocardial injury. Won CH, Chun HJ, Chandra SM, Sarinas PS, Chitkara RK, Heidenreich PA. Sleep Breath. 2013 Mar. PMID: 22294346.", + "An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, McLean DL, Park H, Comhair SA, Greif DM, Erzurum SC, Chun HJ. Nat Med. 2013 Jan; 2012 Dec 23. PMID: 23263626.", + "Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report. McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK, Chun HJ. Arterioscler Thromb Vasc Biol. 2012 Nov; 2012 Sep 20. PMID: 22995518.", + "Mechanisms of dysfunction in senescent pulmonary endothelium. Jane-Wit D, Chun HJ. J Gerontol A Biol Sci Med Sci. 2012 Mar; 2012 Mar 5. PMID: 22396472.", + "Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension. Chandra SM, Razavi H, Kim J, Agrawal R, Kundu RK, de Jesus Perez V, Zamanian RT, Quertermous T, Chun HJ. Arterioscler Thromb Vasc Biol. 2011 Apr; 2011 Jan 13. PMID: 21233449.", + "MicroRNA-26a is a novel regulator of vascular smooth muscle cell function. Leeper NJ, Raiesdana A, Kojima Y, Chun HJ, Azuma J, Maegdefessel L, Kundu RK, Quertermous T, Tsao PS, Spin JM. J Cell Physiol. 2011 Apr. PMID: 20857419.", + "Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse. Kojima Y, Kundu RK, Cox CM, Leeper NJ, Anderson JA, Chun HJ, Ali ZA, Ashley EA, Krieg PA, Quertermous T. Cardiovasc Res. 2010 Jul 1; 2010 Feb 22. PMID: 20176814.", + "Endogenous regulation of cardiovascular function by apelin-APJ. Charo DN, Ho M, Fajardo G, Kawana M, Kundu RK, Sheikh AY, Finsterbach TP, Leeper NJ, Ernst KV, Chen MM, Ho YD, Chun HJ, Bernstein D, Ashley EA, Quertermous T. Am J Physiol Heart Circ Physiol. 2009 Nov; 2009 Sep 18. PMID: 19767528.", + "Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. Chun HJ, Ali ZA, Kojima Y, Kundu RK, Sheikh AY, Agrawal R, Zheng L, Leeper NJ, Pearl NE, Patterson AJ, Anderson JP, Tsao PS, Lenardo MJ, Ashley EA, Quertermous T. J Clin Invest. 2008 Oct. PMID: 18769630.", + "Intracellular and extracellular targets of molecular imaging in the myocardium. Chun HJ, Narula J, Hofstra L, Wu JC. Nat Clin Pract Cardiovasc Med. 2008 Aug. PMID: 18641605.", + "Pacemaker alternans terminated by telemetry wand: what is the mechanism? Chun HJ, Cook K, Wang PJ, Al-Ahmad A. Heart Rhythm. 2008 Jul; 2008 Mar 8. PMID: 18598969.", + "In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure. Sheikh AY, Chun HJ, Glassford AJ, Kundu RK, Kutschka I, Ardigo D, Hendry SL, Wagner RA, Chen MM, Ali ZA, Yue P, Huynh DT, Connolly AJ, Pelletier MP, Tsao PS, Robbins RC, Quertermous T. Am J Physiol Heart Circ Physiol. 2008 Jan; 2007 Sep 28. PMID: 17906101.", + "HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes. Glassford AJ, Yue P, Sheikh AY, Chun HJ, Zarafshar S, Chan DA, Reaven GM, Quertermous T, Tsao PS. Am J Physiol Endocrinol Metab. 2007 Dec; 2007 Sep 18. PMID: 17878221.", + "A novel platform device for rodent echocardiography. Kutschka I, Sheikh AY, Sista R, Hendry SL, Chun HJ, Hoyt G, Kutschka W, Pelletier MP, Quertermous T, Wu JC, Robbins RC. ILAR J. 2007 Jun 6; 2007 Jun 6. PMID: 18506056.", + "Integration of genomics, proteomics, and imaging for cardiac stem cell therapy. Chun HJ, Wilson KO, Huang M, Wu JC. Eur J Nucl Med Mol Imaging. 2007 Jun. PMID: 17464506.", + "Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Chun HJ, Zheng L, Ahmad M, Wang J, Speirs CK, Siegel RM, Dale JK, Puck J, Davis J, Hall CG, Skoda-Smith S, Atkinson TP, Straus SE, Lenardo MJ. Nature. 2002 Sep 26. PMID: 12353035.", + "Caspase-10 is an initiator caspase in death receptor signaling. Wang J, Chun HJ, Wong W, Spencer DM, Lenardo MJ. Proc Natl Acad Sci U S A. 2001 Nov 20. PMID: 11717445.", + "Autoimmune lymphoproliferative syndrome: types I, II and beyond. Chun HJ, Lenardo MJ. Adv Exp Med Biol. 2001. PMID: 11505974.", + "The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. Siegel RM, Chan FK, Chun HJ, Lenardo MJ. Nat Immunol. 2000 Dec. PMID: 11101867.", + "A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Chan FK, Chun HJ, Zheng L, Siegel RM, Bui KL, Lenardo MJ. Science. 2000 Jun 30. PMID: 10875917.", + "NF-AT-Driven interleukin-4 transcription potentiated by NIP45. Hodge MR, Chun HJ, Rengarajan J, Alt A, Lieberson R, Glimcher LH. Science. 1996 Dec 13. PMID: 8943202.", + "300 George Street New Haven, CT 06511", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Chupp Lab", + "lab_url": "https://medicine.yale.edu/lab/chupp/", + "research_bio": "INFORMATION FOR Copy Link Our lab focuses on the Pathogenesis of airway diseases with a focus on asthma and asthma severity, the role of chitinases in the development and severity of asthma, and expression and genotype-phenotype relationships of novel inflammatory molecules. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/chupp/publications/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Pulmonary, Critical Care & Sleep Medicine /", + "Publications", + "Members", + "Contact Us", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Publications", + "Members", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Targeting ST2L potentiates CpG-mediated therapeutic effects in a chronic fungal asthma model. Ramaprakash H, Shibata T, Duffy KE, Ismailoglu UB, Bredernitz RM, Moreira AP, Coelho AL, Das AM, Fursov N, Chupp GL, Hogaboam CM. Am J Pathol. 2011 Jul; 2011 May 14. PMID: 21640974.", + "Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema. Matsuura H, Hartl D, Kang MJ, Dela Cruz CS, Koller B, Chupp GL, Homer RJ, Zhou Y, Cho WK, Elias JA, Lee CG. Am J Respir Cell Mol Biol. 2011 Jun; 2010 Jul 23. PMID: 20656949.", + "Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC. J Exp Med. 2010 Nov 22; 2010 Oct 25. PMID: 20975041.", + "CHIT1 mutations: genetic risk factor for severe asthma with fungal sensitization? Vicencio AG, Chupp GL, Tsirilakis K, He X, Kessel A, Nandalike K, Veler H, Kipperman S, Young MC, Goldman DL. Pediatrics. 2010 Oct; 2010 Sep 6. PMID: 20819891.", + "Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF Jr, Nicolae DL, Elias JA, Chupp GL. N Engl J Med. 2008 Apr 17; 2008 Apr 9. PMID: 18403759.", + "A chitinase-like protein in the lung and circulation of patients with severe asthma. Chupp GL, Lee CG, Jarjour N, Shim YM, Holm CT, He S, Dziura JD, Reed J, Coyle AJ, Kiener P, Cullen M, Grandsaigne M, Dombret MC, Aubier M, Pretolani M, Elias JA. N Engl J Med. 2007 Nov 15. PMID: 18003958.", + "The Anlyan Center for Medical Research & Education 300 Cedar Street New Haven, CT 06510", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Climate, Health, and Environment Nexus (CHEN) Lab", + "lab_url": "https://medicine.yale.edu/lab/kaichen/", + "research_bio": "INFORMATION FOR Copy Link TheClimate,Health, andEnvironmentNexus (CHEN) Lab aims to build a vibrant research group of doctoral students, postdoctoral researchers, and visiting scholars who will apply multidisciplinary approaches – including climate and air pollution sciences, exposure assessment, mathematical and statistical modeling and environmental epidemiology – to investigate the intersection of climate change, air pollution, and human health. We aim to produce policy-relevant knowledge that can be used to advance climate change mitigation and adaptation in a manner that promotes health and protects vulnerable populations. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/kaichen/publications", + "publications": [ + "Yale School of Public Health /", + "Our Team Alumni", + "Alumni", + "News", + "Research Climate Epidemiology Air Pollution and Health Health Co-benefits COVID-19", + "Climate Epidemiology", + "Air Pollution and Health", + "Health Co-benefits", + "COVID-19", + "Opportunities", + "Publications", + "Group Activities & Photos", + "Resources Heat Vulnerability Index", + "Heat Vulnerability Index", + "Prospective Students", + "Alumni", + "Donors", + "Employers", + "Academic Calendar", + "myYSPH Members", + "Support YSPH", + "Our Team", + "Research", + "Publications", + "Resources", + "News", + "Opportunities", + "Group Activities & Photos", + "", + "", + "", + "", + "", + "", + "The role of cardiovascular disease as a mediator in mitigating the impact of ambient PM(2.5) on dementia risk. Lin C, Zhang Y, DeWan AT, Forastiere L, Chen K. Environ Epidemiol. 2025 Dec; 2025 Nov 4. PMID: 41200148.", + "The Pressure Is Rising: Emerging Environmental Determinants of Hypertension. Meng X, Rajagopalan S, Brook RD, Zhang S, Chen K. J Am Coll Cardiol. 2025 Nov 4. PMID: 41162011.", + "Heat- and Cold-Related Mortality Burden in the US From 2000 to 2020. Chu L, Dubrow R, Chen K. JAMA Netw Open. 2025 Nov 3; 2025 Nov 3. PMID: 41201802.", + "Cross-Sectional Association of Ground-Level Ozone and Nitrogen Dioxide With Cardiac Mechanics Using Speckle-Tracking Echocardiography in the Cardiovascular Health Study. Chang AY, Kaufman JD, Shah SJ, Tan AX, Patel RB, Margolis HG, Psaty BM, Gardin JM, Al-Kindi S, Austin TR, Bell ML, Chen K, Odden MC. Echocardiography. 2025 Nov. PMID: 41146536.", + "A Hypothetical PM2.5 Intervention for the Risk of Hospitalization for Cardiovascular Diseases. Lin C, Chu L, Liu R, Gasparrini A, DeWan AT, Forastiere L, Chen K. JAMA Netw Open. 2025 Oct 1; 2025 Oct 1. PMID: 41148138.", + "Mortality risk and burden associated with non-optimum temperatures in Puerto Rico. Díaz-Collado F, Chu L, Carrión D, Méndez-Lázaro PA, Chen K. Environ Res Lett. 2025 Oct 1; 2025 Sep 9. PMID: 40932903.", + "Racial and ethnic disparities in exposure to short-term NO(2) air pollution in California during 1980-2022. Liu R, Chu L, Rogne T, Ma X, Chen K. J Hazard Mater. 2025 Sep 15; 2025 Jul 19. PMID: 40695125.", + "The Lancet Countdown Report: missing links in climate action. Rogne T, Chen K, Magnus JH. Lancet. 2025 Aug 30. PMID: 40885575.", + "Metrics of Urbanicity and Rurality in US-Based Epidemiologic Studies of Ambient Temperature and Health: A Scoping Review. Johnson NP, Del Favero-Campbell A, Nori-Sarma A, Amezcua-Smith A, Lewis B, Chen C, Lin C, Foo D, Byun G, Choi HM, Kim H, Berman JD, Son JY, Warren JL, Chen K, Burrows K, Fong KC, Goldsmith L, Meadows MC, Smith M, Stewart R, Heo S, Lin S, Ning X, Choi Y, Bell ML, Deziel NC. Curr Environ Health Rep. 2025 Aug 20; 2025 Aug 20. PMID: 40830732.", + "Drought, Extreme Heat, and Intimate Partner Violence in Low- and Middle-Income Countries. Wang P, Chu L, Ban J, Asare EO, Sivakami M, Henao AR, Chimoyi L, Sullivan TP, Chen K. JAMA Netw Open. 2025 Aug 1; 2025 Aug 1. PMID: 40833696.", + "Joint Exposure to Ozone and Temperature and Acute Myocardial Infarction Among Adults Aged 18 to 64 Years in the United States. Chu L, Wang R, Gross CP, Wei J, Lu Y, Krumholz HM, Ma X, Chen K. Circulation. 2025 Jul 29; 2025 Jun 3. PMID: 40458867.", + "Fire Smoke Elevated the Carbonaceous PM(2.5) Concentration and Mortality Burden in the Contiguous U.S. and Southern Canada. Jin Z, Ferrada GA, Zhang D, Scovronick N, Fu JS, Chen K, Liu Y. Environ Sci Technol. 2025 Jun 24; 2025 Jun 12. PMID: 40504638.", + "Mental health impacts of particulate matter exposure and non-optimal temperature among rural and urban children in eastern China. Wu Y, Wei J, Cheng B, Sun H, Zhou Y, Li C, Wang P, Zhang H, Wang Y, Huang L, Chen K. Npj Ment Health Res. 2025 May 19; 2025 May 19. PMID: 40389549.", + "Population aging exacerbates heat stroke-related ambulance transportations in Japan. Guo Q, Madaniyazi L, Nomura S, Chen K, Hashizume M. Environ Int. 2025 May; 2025 Apr 30. PMID: 40319630.", + "Short-term exposure to ambient nitrogen dioxide and fine particulate matter and cause-specific mortality: A causal modeling approach in four regions. Marb A, Ma Y, Nobile F, Dubrow R, Kinney PL, Stafoggia M, Chen K, Peters A, Breitner S. Environ Pollut. 2025 May 1; 2025 Mar 13. PMID: 40089139.", + "Reply: Strengthening Temperature-Stroke Associations: Methodologic Considerations. Chu L, Ma X, Chen K. J Am Coll Cardiol. 2025 Apr 15. PMID: 40204383.", + "Estimating the Effects of Hypothetical Ambient PM2.5 Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank Cohort. Lin C, Liu R, Sutton C, DeWan AT, Forastiere L, Chen K. Environ Health Perspect. 2025 Apr; 2025 Apr 16. PMID: 40062909.", + "Floods and cause-specific mortality in the United States applying a triply robust approach. Chu L, Warren JL, Spatz ES, Lowe S, Lu Y, Ma X, Ross JS, Krumholz HM, Chen K. Nat Commun. 2025 Mar 23; 2025 Mar 23. PMID: 40122917.", + "Understanding the Cardiovascular Impacts of Heatwaves: Moving Beyond Simple Definitions. Chu L, Chen K. J Am Coll Cardiol. 2025 Mar 17; 2025 Mar 17. PMID: 40131260.", + "Short-Term Associations Between Ambient Ozone and Acute Myocardial Infarction Onset Among Younger Patients: Results From the VIRGO Study. Zhang S, Chu L, Lu Y, Wei J, Dubrow R, Chaudhry SI, Spatz E, Krumholz H, Chen K. Geohealth. 2025 Feb; 2025 Feb 18. PMID: 39968338.", + "The Pathogenetic Link Between Ozone Pollution and Cardiovascular Disease. Schneider A, Chen K, Breitner S. J Am Coll Cardiol. 2025 Feb 18; 2025 Jan 22. PMID: 39846937.", + "EnvironMental Health: A Framework for an Emerging Field at the Intersection of the Environment and Mental Health Crises. Ratjen L, Goddard E, Gilcher EB, Nguyen BK, Kelley M, Feldman HS, Akalaonu K, Nyhan K, Backhaus A, López Lascurain M, Wyrtzen NE, Smiley Smith S, Prabhu M, Lowe SR, Chen K, Zimmerman JB, Anastas PT. Geohealth. 2025 Feb; 2025 Feb 14. PMID: 39958831.", + "Long-term drought and risk of infant mortality in Africa: A cross-sectional study. Wang P, Rogne T, Warren JL, Asare EO, Akum RA, Toure NE, Ross JS, Chen K. PLoS Med. 2025 Jan; 2025 Jan 31. PMID: 39888958.", + "Hot Under the Collar: Humidity, Heat, and Heart Rhythms. Al-Kindi S, Ardakani J, Chen K. JACC Adv. 2025 Jan; 2024 Dec 13. PMID: 39759437.", + "Ambient Temperature and Stroke Risk Among Adults Aged 18-64 Years: A Case-Crossover Study. Chu L, Wang R, Gross CP, Chen K, Ma X. J Am Coll Cardiol. 2024 Dec 3; 2024 Oct 23. PMID: 39453364.", + "Fire Smoke Elevated the Carbonaceous PM(2.5) Concentration and Mortality Burden in the Contiguous U.S. and Southern Canada. Jin Z, Ferrada GA, Zhang D, Scovronick N, Fu JS, Chen K, Liu Y. Res Sq. 2024 Nov 21; 2024 Nov 21. PMID: 39606454.", + "Rainfall events and daily mortality across 645 global locations: two stage time series analysis. He C, Breitner-Busch S, Huber V, Chen K, Zhang S, Gasparrini A, Bell M, Kan H, Royé D, Armstrong B, Schwartz J, Sera F, Vicedo-Cabrera AM, Honda Y, Jaakkola JJK, Ryti N, Kyselý J, Guo Y, Tong S, de'Donato F, Michelozzi P, Coelho MSZS, Saldiva PHN, Lavigne E, Orru H, Indermitte E, Pascal M, Goodman P, Zeka A, Kim Y, Diaz MH, Arellano EEF, Overcenco A, Klompmaker J, Rao S, Palomares AD, Carrasco G, Seposo X, Pereira da Silva SDN, Madureira J, Holobaca IH, Scovronick N, Acquaotta F, Kim H, Lee W, Hashizume M, Tobias A, Íñiguez C, Forsberg B, Ragettli MS, Guo YL, Pan SC, Osorio S, Li S, Zanobetti A, Dang TN, Van Dung D, Schneider A. BMJ. 2024 Oct 9; 2024 Oct 9. PMID: 39384295.", + "Long-term exposure to wildland fire smoke PM(2.5) and mortality in the contiguous United States. Ma Y, Zang E, Liu Y, Wei J, Lu Y, Krumholz HM, Bell ML, Chen K. Proc Natl Acad Sci U S A. 2024 Oct; 2024 Sep 24. PMID: 39316057.", + "Landscape Fire Air Pollution as a Mediator in Drought and Childhood Stunting Pathway in Low- and Middle-Income Countries. Li JJ, Wang P, Sutton C, Harker R, Xue T, Chen K. Environ Sci Technol. 2024 Sep 24; 2024 Sep 11. PMID: 39259849.", + "Balancing the Climate Equation: The Unseen Cardiovascular Threat of Cold Spells in a Warming World. Chen K, Nasir K. J Am Coll Cardiol. 2024 Sep 24; 2024 Sep 1. PMID: 39230542.", + "High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study. Rogne T, Wang R, Wang P, Deziel NC, Metayer C, Wiemels JL, Chen K, Warren JL, Ma X. Lancet Planet Health. 2024 Jul. PMID: 38969477.", + "Long-term exposure to wildland fire smoke PM(2.5) and mortality in the contiguous United States. Ma Y, Zang E, Liu Y, Wei J, Lu Y, Krumholz HM, Bell ML, Chen K. medRxiv. 2024 Jun 11; 2024 Jun 11. PMID: 36778437.", + "Comprehensive evaluation framework for intervention on health effects of ambient temperature. Wang J, Wang P, Liu B, Kinney PL, Huang L, Chen K. Eco Environ Health. 2024 Jun; 2024 Jan 28. PMID: 38646097.", + "Air pollution changes due to COVID-19 lockdowns and attributable mortality changes in four countries. Ma Y, Nobile F, Marb A, Dubrow R, Kinney PL, Peters A, Stafoggia M, Breitner S, Chen K. Environ Int. 2024 May; 2024 Apr 16. PMID: 38640613.", + "A unified framework for assessing interaction effects among environmental exposures in epidemiologic studies: A case study on temperature, air pollution, and kidney-related conditions in New York state. Chu L, Chen K, Yang Z, Crowley S, Dubrow R. Environ Res. 2024 May 1; 2024 Feb 1. PMID: 38301759.", + "Short-Term Exposure to Fine Particulate Matter and Nitrogen Dioxide and Mortality in 4 Countries. Ma Y, Nobile F, Marb A, Dubrow R, Stafoggia M, Breitner S, Kinney PL, Chen K. JAMA Netw Open. 2024 Mar 4; 2024 Mar 4. PMID: 38427355.", + "Bidirectional modification effects on nonlinear associations of summer temperature and air pollution with first-ever stroke morbidity. Yang C, Lei L, Li Y, Huang C, Chen K, Bao J. Ecotoxicol Environ Saf. 2024 Mar 1; 2024 Feb 3. PMID: 38310820.", + "Impact of population aging on future temperature-related mortality at different global warming levels. Chen K, de Schrijver E, Sivaraj S, Sera F, Scovronick N, Jiang L, Roye D, Lavigne E, Kyselý J, Urban A, Schneider A, Huber V, Madureira J, Mistry MN, Cvijanovic I, Gasparrini A, Vicedo-Cabrera AM. Nat Commun. 2024 Feb 27; 2024 Feb 27. PMID: 38413648.", + "Ozone-related acute excess mortality projected to increase in the absence of climate and air quality controls consistent with the Paris Agreement. Domingo NGG, Fiore AM, Lamarque JF, Kinney PL, Jiang L, Gasparrini A, Breitner S, Lavigne E, Madureira J, Masselot P, das Neves Pereira da Silva S, Sheng Ng CF, Kyselý J, Guo Y, Tong S, Kan H, Urban A, Orru H, Maasikmets M, Pascal M, Katsouyanni K, Samoli E, Scortichini M, Stafoggia M, Hashizume M, Alahmad B, Diaz MH, la Cruz Valencia C, Scovronick N, Garland RM, Kim H, Lee W, Tobias A, Íñiguez C, Forsberg B, Åström C, Ragettli MS, Guo YL, Pan SC, Colistro V, Bell M, Zanobetti A, Schwartz J, Schneider A, Vicedo-Cabrera AM, Chen K. One Earth. 2024 Feb 16. PMID: 38420618.", + "Prioritizing the Exposome to Reduce Cardiovascular Disease Burden. Spatz ES, Chen K, Krumholz HM. JAMA Cardiol. 2024 Feb 1. PMID: 37955872.", + "Integrating Augmented In Situ Measurements and a Spatiotemporal Machine Learning Model To Back Extrapolate Historical Particulate Matter Pollution over the United Kingdom: 1980-2019. Liu R, Ma Z, Gasparrini A, de la Cruz A, Bi J, Chen K. Environ Sci Technol. 2023 Dec 26; 2023 Dec 12. PMID: 38085698.", + "Besieged on all sides: the future burden of high-temperature-related kidney disease. Chu L, Chen K. Lancet Reg Health West Pac. 2023 Dec; 2023 Oct 20. PMID: 37886030.", + "Racial/ethnic disparities in PM(2.5)-attributable cardiovascular mortality burden in the United States. Ma Y, Zang E, Opara I, Lu Y, Krumholz HM, Chen K. Nat Hum Behav. 2023 Dec; 2023 Aug 31. PMID: 37653149.", + "Floods and Diarrhea Risk in Young Children in Low- and Middle-Income Countries. Wang P, Asare EO, Pitzer VE, Dubrow R, Chen K. JAMA Pediatr. 2023 Nov 1. PMID: 37782513.", + "Canadian Wildfire Smoke and Asthma Syndrome Emergency Department Visits in New York City. Chen K, Ma Y, Bell ML, Yang W. JAMA. 2023 Oct 10. PMID: 37733685.", + "Long-Term Exposure to Fine Particulate Matter and Academic Performance Among Children in North Carolina. Lam PH, Zang E, Chen D, Liu R, Chen K. JAMA Netw Open. 2023 Oct 2; 2023 Oct 2. PMID: 37906198.", + "Future temperature-related excess mortality under climate change and population aging scenarios in Canada. Hebbern C, Gosselin P, Chen K, Chen H, Cakmak S, MacDonald M, Chagnon J, Dion P, Martel L, Lavigne E. Can J Public Health. 2023 Oct; 2023 Jun 12. PMID: 37308698.", + "Nationwide projections of heat- and cold-related mortality impacts under various climate change and population development scenarios in Switzerland. de Schrijver E, Sivaraj S, Raible CC, Franco OH, Chen K, Vicedo-Cabrera AM. Environ Res Lett. 2023 Aug 11. PMID: 38854588.", + "Associations between short-term exposure to PM(2.5), NO(2) and O(3) pollution and kidney-related conditions and the role of temperature-adjustment specification: A case-crossover study in New York state. Chu L, Chen K, Di Q, Crowley S, Dubrow R. Environ Pollut. 2023 Jul 1; 2023 Apr 11. PMID: 37054868.", + "Assessment of Regional Nursing Home Preparedness for and Regulatory Responsiveness to Wildfire Risk in the Western US. Festa N, Throgmorton KF, Davis-Plourde K, Dosa DM, Chen K, Zang E, Kelly J, Gill TM. JAMA Netw Open. 2023 Jun 1; 2023 Jun 1. PMID: 37358851.", + "High Ambient Temperature in Pregnancy and Risk of Childhood Acute Lymphoblastic Leukemia. Rogne T, Wang R, Wang P, Deziel NC, Metayer C, Wiemels JL, Chen K, Warren JL, Ma X. medRxiv. 2023 May 19; 2023 May 19. PMID: 37293058.", + "Temperature variability and birthweight: Epidemiological evidence from Africa. Wang P, O'Donnell KJ, Warren JL, Dubrow R, Chen K. Environ Int. 2023 Mar; 2023 Feb 2. PMID: 36841185.", + "Associations between short-term temperature exposure and kidney-related conditions in New York State: The influence of temperature metrics across four dimensions. Chu L, Chen K, Crowley S, Dubrow R. Environ Int. 2023 Mar; 2023 Jan 30. PMID: 36841184.", + "High-resolution spatiotemporal modeling of daily near-surface air temperature in Germany over the period 2000-2020. Nikolaou N, Dallavalle M, Stafoggia M, Bouwer LM, Peters A, Chen K, Wolf K, Schneider A. Environ Res. 2023 Feb 15; 2022 Dec 17. PMID: 36535393.", + "Residential and Race/Ethnicity Disparities in Heat Vulnerability in the United States. Manware M, Dubrow R, Carrión D, Ma Y, Chen K. Geohealth. 2022 Dec; 2022 Dec 1. PMID: 36518814.", + "Projecting future health burden associated with exposure to ambient PM(2.5) and ozone in China under different climate scenarios. Wang Y, Hu J, Huang L, Li T, Yue X, Xie X, Liao H, Chen K, Wang M. Environ Int. 2022 Nov; 2022 Sep 24. PMID: 36194980.", + "Future temperature-related mortality considering physiological and socioeconomic adaptation: a modelling framework. Rai M, Breitner S, Wolf K, Peters A, Schneider A, Chen K. Lancet Planet Health. 2022 Oct. PMID: 36208641.", + "Triggering of myocardial infarction by heat exposure is modified by medication intake. Chen K, Dubrow R, Breitner S, Wolf K, Linseisen J, Schmitz T, Heier M, von Scheidt W, Kuch B, Meisinger C, Peters A, Schneider A. Nat Cardiovasc Res. 2022 Aug; 2022 Aug 1. PMID: 39196082.", + "Associations between short-term ambient ozone exposure and cause-specific mortality in rural and urban areas of Jiangsu, China. Lin C, Ma Y, Liu R, Shao Y, Ma Z, Zhou L, Jing Y, Bell ML, Chen K. Environ Res. 2022 Aug; 2022 Mar 12. PMID: 35288156.", + "Associations between long-term drought and diarrhea among children under five in low- and middle-income countries. Wang P, Asare E, Pitzer VE, Dubrow R, Chen K. Nat Commun. 2022 Jun 30; 2022 Jun 30. PMID: 35773263.", + "Public anxiety through various stages of COVID-19 coping: Evidence from China. Wu Y, Zhang T, Ye Z, Chen K, Kuijp JV, Sun X, Han G, Zhao Y, Liu Y, Huang L. PLoS One. 2022; 2022 Jun 16. PMID: 35709292.", + "Short-term effects of cold spells on plasma viscosity: Results from the KORA cohort study in Augsburg, Germany. Ni W, Schneider A, Wolf K, Zhang S, Chen K, Koenig W, Peters A, Breitner S. Environ Pollut. 2022 Jun 1; 2022 Feb 26. PMID: 35231540.", + "Predicting spatiotemporally-resolved mean air temperature over Sweden from satellite data using an ensemble model. Jin Z, Ma Y, Chu L, Liu Y, Dubrow R, Chen K. Environ Res. 2022 Mar; 2021 Aug 28. PMID: 34464620.", + "Long-term ozone exposure and cognitive impairment among Chinese older adults: A cohort study. Gao Q, Zang E, Bi J, Dubrow R, Lowe SR, Chen H, Zeng Y, Shi L, Chen K. Environ Int. 2022 Feb; 2022 Jan 1. PMID: 34979350.", + "Short-term associations between particulate matter air pollution and hospital admissions through the emergency room for urinary system disease in Beijing, China: A time-series study. Chu L, Du H, Li T, Lu F, Guo M, Dubrow R, Chen K. Environ Pollut. 2021 Nov 15; 2021 Jul 29. PMID: 34388554.", + "Exposure and perception of PM(2.5) pollution on the mental stress of pregnant women. Li J, Huang L, Han B, van der Kuijp TJ, Xia Y, Chen K. Environ Int. 2021 Nov; 2021 Jun 15. PMID: 34139481.", + "Association between extreme temperatures and emergency room visits related to mental disorders: A multi-region time-series study in New York, USA. Yoo EH, Eum Y, Roberts JE, Gao Q, Chen K. Sci Total Environ. 2021 Oct 20; 2021 Jun 8. PMID: 34144243.", + "Projection of Temperature-Related Excess Mortality by Integrating Population Adaptability Under Changing Climate - China, 2050s and 2080s. Sun Z, Wang Q, Chen C, Yang Y, Yan M, Du H, Chen K, Ji JS, Li T. China CDC Wkly. 2021 Aug 13. PMID: 34594971.", + "Effect of extreme temperatures on daily emergency room visits for mental disorders. Yoo EH, Eum Y, Gao Q, Chen K. Environ Sci Pollut Res Int. 2021 Aug; 2021 Mar 22. PMID: 33751353.", + "Solid fuels use for cooking and sleep health in adults aged 45 years and older in China. Yu H, Luo J, Chen K, Pollitt KJG, Liew Z. Sci Rep. 2021 Jun 25; 2021 Jun 25. PMID: 34172775.", + "Role of meteorological factors in the transmission of SARS-CoV-2 in the United States. Ma Y, Pei S, Shaman J, Dubrow R, Chen K. Nat Commun. 2021 Jun 14; 2021 Jun 14. PMID: 34127665.", + "Population ageing and deaths attributable to ambient PM(2·5) pollution: a global analysis of economic cost. Yin H, Brauer M, Zhang JJ, Cai W, Navrud S, Burnett R, Howard C, Deng Z, Kammen DM, Schellnhuber HJ, Chen K, Kan H, Chen ZM, Chen B, Zhang N, Mi Z, Coffman D, Cohen AJ, Guan D, Zhang Q, Gong P, Liu Z. Lancet Planet Health. 2021 Jun. PMID: 34119010.", + "Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities. Chen K, Breitner S, Wolf K, Stafoggia M, Sera F, Vicedo-Cabrera AM, Guo Y, Tong S, Lavigne E, Matus P, Valdés N, Kan H, Jaakkola JJK, Ryti NRI, Huber V, Scortichini M, Hashizume M, Honda Y, Nunes B, Madureira J, Holobâcă IH, Fratianni S, Kim H, Lee W, Tobias A, Íñiguez C, Forsberg B, Åström C, Ragettli MS, Guo YL, Chen BY, Li S, Milojevic A, Zanobetti A, Schwartz J, Bell ML, Gasparrini A, Schneider A. Lancet Planet Health. 2021 Apr. PMID: 33838734.", + "Particulate matter pollution and risk of outpatient visits for psychological diseases in Nanjing, China. Lowe SR, Wang C, Ma Y, Chen K. Environ Res. 2021 Feb; 2020 Dec 8. PMID: 33307087.", + "Role of air temperature and humidity in the transmission of SARS-CoV-2 in the United States. Ma Y, Pei S, Shaman J, Dubrow R, Chen K. medRxiv. 2020 Nov 16; 2020 Nov 16. PMID: 33236018.", + "Burden of cause-specific mortality attributable to heat and cold: A multicity time-series study in Jiangsu Province, China. Ma Y, Zhou L, Chen K. Environ Int. 2020 Nov; 2020 Jul 31. PMID: 32745780.", + "Projections of Ambient Temperature- and Air Pollution-Related Mortality Burden Under Combined Climate Change and Population Aging Scenarios: a Review. Chen K, Vicedo-Cabrera AM, Dubrow R. Curr Environ Health Rep. 2020 Sep. PMID: 32542573.", + "Reduction in air pollution and attributable mortality due to COVID-19 lockdown - Authors' reply. Chen K, Wang M, Kinney PL, Anastas PT. Lancet Planet Health. 2020 Jul. PMID: 32681896.", + "Air pollution reduction and mortality benefit during the COVID-19 outbreak in China. Chen K, Wang M, Huang C, Kinney PL, Anastas PT. Lancet Planet Health. 2020 Jun; 2020 May 13. PMID: 32411944.", + "Particulate matter pollution and hospital outpatient visits for endocrine, digestive, urological, and dermatological diseases in Nanjing, China. Wang C, Zhu G, Zhang L, Chen K. Environ Pollut. 2020 Jun; 2020 Feb 20. PMID: 32113107.", + "Living in a highly polluted and warmer environment: Challenges for cardiovascular prevention. Vicedo-Cabrera AM, Chen K. Eur J Prev Cardiol. 2020 Mar; 2019 Aug 22. PMID: 31438724.", + "Hourly Exposure to Ultrafine Particle Metrics and the Onset of Myocardial Infarction in Augsburg, Germany. Chen K, Schneider A, Cyrys J, Wolf K, Meisinger C, Heier M, von Scheidt W, Kuch B, Pitz M, Peters A, Breitner S. Environ Health Perspect. 2020 Jan; 2020 Jan 15. PMID: 31939685.", + "Burden of myocardial infarctions attributable to heat and cold. Chen K, Peters A, Schneider A. Eur Heart J. 2019 Nov 1. PMID: 31674650.", + "Calendar", + "Maps & Directions", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Clinical and Translational Neuromuscular Research", + "lab_url": "https://medicine.yale.edu/lab/nowak/", + "research_bio": "INFORMATION FOR The Program in Clinical & Translational Neuromuscular Research (CTNR) is focused on bridging the gap between clinical care and the basic sciences and neuromuscular disorders. This translational research program was officially formed in October 2012 under the leadership of Dr. Richard Nowak. While the program is based within the Department of Neurology and rooted in the Division of Neuromuscular Medicine, we are committed to collaboration across many disciplines such as immunology, genetics, and biochemistry. Our primary research focus has been on immune-mediated neuromuscular diseases such as myasthenia gravis (MG) and inflammatory neuropathies and myopathies (e.g. Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), Inclusion Body Myositis). We believe that fostering close collaboration between clinicians and basic scientists is critical in successfully advancing our understanding of these disorders and translating these discoveries into clinical practice. Biomarker discovery and working to the end of patient-tailored treatment strategy development is our major overall objective. Our program is also a part of the Muscle Study Group (MSG), which is a consortium of scientific investigators among academic and research centers committed to the cooperative planning, implementation, analysis, and reporting of controlled clinical trials and of other research for muscle and other neuromuscular diseases. Since formation of this program, we have initiated eight studies five of which are focused on MG. Early observations made by our group and others showing the benefit of B-cell-targeted therapy (rituximab) for MG has compelled us to explore this further. The success of this program is highlighted by the fact that Dr. Nowak was awarded a 4.8 million dollar grantin 2013 to conduct the first NIH-sponsored clinical trial in MG and is the national principal investigator for the multi-center study entitled A Phase 2 Trial of Rituximab in Myasthenia Gravis. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/nowak/publications", + "publications": [ + "Yale School of Medicine /", + "Neurology /", + "Research", + "Selected Publications", + "Studies & Trials", + "Contact Us", + "Members", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Studies & Trials", + "Members", + "News", + "Selected Publications", + "Contact Us", + "", + "", + "", + "", + "", + "", + "IgA autoantibodies demonstrate a novel mechanism of MuSK myasthenia gravis pathology. Masi G, Chen K, Bayer AC, Bayarri-Olmos R, Pham MC, Wallace A, Falso S, Evoli A, Iorio R, Hoehn KB, Iwasaki A, Nowak RJ, O'Connor KC. Brain. 2025 Oct 28; 2025 Oct 28. PMID: 41147199.", + "Therapeutic IgG- and IgM-specific proteases disarm the acetylcholine receptor autoantibodies that drive myasthenia gravis pathology. Bayer AC, Sanmarco LM, Pellerin A, Masi G, Plasencia A, Anderson JM, Nowak RJ, Damato V, Massacesi L, Pham MC, Khani-Habibabadi F, Vital H, Higginson-Scott N, Otipoby KL, Xing Y, Mascanfroni ID, O'Connor KC. Proc Natl Acad Sci U S A. 2025 Oct 28; 2025 Oct 21. PMID: 41118207.", + "A Distinct Immunological Signature in Late-Onset Myasthenia Gravis: Insights from an Exploratory Proteomics Study. Roy B, Chen J, Khani-Habibabadi F, McLaren N, Soliven BC, Juel VC, O'Connor KC, Nowak RJ, Kusner LL, Kaminski HJ. Ann Neurol. 2025 Sep 6; 2025 Sep 6. PMID: 40913424.", + "AChR Autoantibody Pathogenic Properties Are Heterogeneously Distributed and Undergo Temporal Changes Among Patients With Myasthenia Gravis. Khani-Habibabadi F, Roy B, Pham MC, Obaid AH, Filipek B, Nowak RJ, O'Connor KC. Neurol Neuroimmunol Neuroinflamm. 2025 Sep; 2025 Jul 18. PMID: 40680247.", + "Understanding Racial and Ethnic Disparities in Myasthenia Gravis Outcomes: EXPLORE-MG Registry Experience. McLaren NP, Roy B, Nowak RJ. Neurol Clin Pract. 2025 Aug; 2025 Jun 18. PMID: 40584640.", + "Epidemiology and patient characteristics of the US myasthenia gravis population: real-world evidence from a large insurance claims database. Miller-Wilson LA, Arackal J, Edwards Y, Schwinn J, Rockstein KE, Venker B, Nowak RJ. BMJ Neurol Open. 2025; 2025 Jun 23. PMID: 40556711.", + "A Phase 3 Trial of Inebilizumab in Generalized Myasthenia Gravis. Nowak RJ, Benatar M, Ciafaloni E, Howard JF Jr, Leite MI, Utsugisawa K, Vissing J, Rojavin M, Li Q, Tang F, Wu Y, Rampal N, Cheng S. N Engl J Med. 2025 Jun 19; 2025 Apr 8. PMID: 40202593.", + "Risk of Exacerbation and Level of Healthcare Resource Utilization in Myasthenia Gravis Assessed by Myasthenia Gravis Activities of Daily Living Score. Ting A, Park M, Sangha O, Kumar M, Ricci JF, Lee E, Nowak RJ. Neurol Ther. 2025 Apr; 2025 Feb 17. PMID: 39961947.", + "Safety and efficacy of nipocalimab in adults with generalised myasthenia gravis (Vivacity-MG3): a phase 3, randomised, double-blind, placebo-controlled study. Antozzi C, Vu T, Ramchandren S, Nowak RJ, Farmakidis C, Bril V, De Bleecker J, Yang H, Minks E, Park JS, Grudniak M, Smilowski M, Sevilla T, Hoffmann S, Sivakumar K, Suzuki Y, Youssef E, Sanga P, Karcher K, Zhu Y, Sheehan JJ, Sun H. Lancet Neurol. 2025 Feb. PMID: 39862879.", + "CMT2 and distal hereditary motor neuropathy associated with VRK1 variants: Case series. Živković SA, Nowak RJ, DiCapua D. Neuromuscul Disord. 2025 Feb; 2024 Nov 29. PMID: 39693713.", + "Contribution of cellular immune dysregulation to myasthenia gravis pathology. Bayer AC, Nowak RJ, O'Connor KC. Int Rev Neurobiol. 2025; 2025 May 20. PMID: 40675740.", + "Antigen-specific immune therapy (CNP-106) for treatment of generalised myasthenia gravis: rationale and design of first-in-human randomised controlled trial. G Brew S, Frey M, P McCarthy D, Elhofy A, Nowak RJ. BMJ Neurol Open. 2024; 2024 Dec 18. PMID: 39720510.", + "Application of digital tools and artificial intelligence in the Myasthenia Gravis Core Examination. Garbey M, Lesport Q, Girma H, Öztosun G, Abu-Rub M, Guidon AC, Juel V, Nowak RJ, Soliven B, Aban I, Kaminski HJ. Front Neurol. 2024; 2024 Dec 4. PMID: 39697445.", + "US Clinical Practice Experience with Eculizumab in Myasthenia Gravis: Acute Clinical Events and Healthcare Resource Utilization. Nowak RJ, Habib AA, Klink AJ, Muppidi S, Parthan A, Sader SC, Balanean A, Gajra A, Howard JF Jr. Drugs Real World Outcomes. 2024 Dec; 2024 Oct 29. PMID: 39470958.", + "Fluorescence-detection size-exclusion chromatography specifically detects autoantibodies targeting the ganglionic acetylcholine receptor in patients with autoimmune autonomic ganglionopathy. Baxter L, Hopkins S, O'Connor KC, Pham MC, Nowak RJ, Monson NL, Blackburn K, Hibbs RE, Vernino S, Noviello CM. J Neuroimmunol. 2024 Nov 15; 2024 Sep 8. PMID: 39277987.", + "United States clinical practice experience with eculizumab in myasthenia gravis: symptoms, function, and immunosuppressant therapy use. Habib AA, Klink AJ, Muppidi S, Parthan A, Sader SC, Balanean A, Gajra A, Nowak RJ, Howard JF Jr. J Neurol. 2024 Sep; 2024 Jul 25. PMID: 39052039.", + "Unveiling the proteome-wide autoreactome enables enhanced evaluation of emerging CAR T cell therapies in autoimmunity. Bodansky A, Yu DJ, Rallistan A, Kalaycioglu M, Boonyaratanakornkit J, Green DJ, Gauthier J, Turtle CJ, Zorn K, O'Donovan B, Mandel-Brehm C, Asaki J, Kortbawi H, Kung AF, Rackaityte E, Wang CY, Saxena A, de Dios K, Masi G, Nowak RJ, O'Connor KC, Li H, Diaz VE, Saloner R, Casaletto KB, Gontrum EQ, Chan B, Kramer JH, Wilson MR, Utz PJ, Hill JA, Jackson SW, Anderson MS, DeRisi JL. J Clin Invest. 2024 May 16; 2024 May 16. PMID: 38753445.", + "Long-term safety and efficacy of zilucoplan in patients with generalized myasthenia gravis: interim analysis of the RAISE-XT open-label extension study. Howard JF Jr, Bresch S, Farmakidis C, Freimer M, Genge A, Hewamadduma C, Hinton J, Hussain Y, Juntas-Morales R, Kaminski HJ, Maniaol A, Mantegazza R, Masuda M, Nowak RJ, Sivakumar K, Śmiłowski M, Utsugisawa K, Vu T, Weiss MD, Zajda M, Bloemers J, Boroojerdi B, Brock M, de la Borderie G, Duda PW, Vanderkelen M, Leite MI. Ther Adv Neurol Disord. 2024; 2024 Apr 17. PMID: 38638673.", + "A Noncanonical CD56dimCD16dim/- NK Cell Subset Indicative of Prior Cytotoxic Activity Is Elevated in Patients with Autoantibody-Mediated Neurologic Diseases. Yandamuri SS, Filipek B, Lele N, Cohen I, Bennett JL, Nowak RJ, Sotirchos ES, Longbrake EE, Mace EM, O'Connor KC. J Immunol. 2024 Mar 1. PMID: 38251887.", + "Safety and Efficacy of Nipocalimab in Patients With Generalized Myasthenia Gravis: Results From the Randomized Phase 2 Vivacity-MG Study. Antozzi C, Guptill J, Bril V, Gamez J, Meuth SG, Nowak RJ, Quan D, Sevilla T, Jouvin MH, Jin J, Karcher K, Ramchandren S, Sun H, Ling L, Zhu Y, Arroyo S. Neurology. 2024 Jan 23; 2023 Dec 21. PMID: 38165333.", + "Batoclimab as induction and maintenance therapy in patients with myasthenia gravis: rationale and study design of a phase 3 clinical trial. Benatar M, Wiendl H, Nowak R, Zheng Y, Macias W. BMJ Neurol Open. 2024; 2024 Jan 10. PMID: 38268752.", + "Subcutaneous batoclimab in generalized myasthenia gravis: Results from a Phase 2a trial with an open-label extension. Nowak RJ, Breiner A, Bril V, Allen JA, Khan S, Levine T, Jacobs DH, Sahagian G, Siddiqi ZA, Xu J, Macias WL, Benatar M. Ann Clin Transl Neurol. 2024 Jan; 2023 Dec 7. PMID: 38062618.", + "Unveiling the autoreactome: Proteome-wide immunological fingerprints reveal the promise of plasma cell depleting therapy. Bodansky A, Yu DJ, Rallistan A, Kalaycioglu M, Boonyaratanakornkit J, Green DJ, Gauthier J, Turtle CJ, Zorn K, O'Donovan B, Mandel-Brehm C, Asaki J, Kortbawi H, Kung AF, Rackaityte E, Wang CY, Saxena A, de Dios K, Masi G, Nowak RJ, O'Connor KC, Li H, Diaz VE, Casaletto KB, Gontrum EQ, Chan B, Kramer JH, Wilson MR, Utz PJ, Hill JA, Jackson SW, Anderson MS, DeRisi JL. medRxiv. 2023 Dec 20; 2023 Dec 20. PMID: 38196603.", + "Remission of severe myasthenia gravis after autologous stem cell transplantation. Schlatter MI, Yandamuri SS, O'Connor KC, Nowak RJ, Pham MC, Obaid AH, Redman C, Provost M, McSweeney PA, Pearlman ML, Tees MT, Bowen JD, Nash RA, Georges GE. Ann Clin Transl Neurol. 2023 Nov; 2023 Sep 19. PMID: 37726935.", + "Addressing Outcome Measure Variability in Myasthenia Gravis Clinical Trials. Guptill JT, Benatar M, Granit V, Habib AA, Howard JF Jr, Barnett-Tapia C, Nowak RJ, Lee I, Ruzhansky K, Dimachkie MM, Cutter GR, Kaminski HJ. Neurology. 2023 Sep 5; 2023 Apr 19. PMID: 37076302.", + "Leg MRI as a Complementary Diagnostic Tool in the Assessment of Foot Drop. Torabi T, Zubair AS, Nowak RJ, Tseng B, Haims A, Roy B. J Clin Neuromuscul Dis. 2023 Sep 1. PMID: 37611274.", + "Plasmapheresis Versus Intravenous Immunoglobulin in Patients With Autoimmune Neuromuscular and Neuro-immunological Conditions. Zubair AS, Rethana M, Ma A, McAlpine LS, Abulaban A, Munro BS, Patwa HS, Nowak RJ, Roy B. J Clin Neuromuscul Dis. 2023 Sep 1. PMID: 37611265.", + "Individual myasthenia gravis autoantibody clones can efficiently mediate multiple mechanisms of pathology. Pham MC, Masi G, Patzina R, Obaid AH, Oxendine SR, Oh S, Payne AS, Nowak RJ, O'Connor KC. Acta Neuropathol. 2023 Aug; 2023 Jun 21. PMID: 37344701.", + "MOGAD patient autoantibodies induce complement, phagocytosis, and cellular cytotoxicity. Yandamuri SS, Filipek B, Obaid AH, Lele N, Thurman JM, Makhani N, Nowak RJ, Guo Y, Lucchinetti CF, Flanagan EP, Longbrake EE, O'Connor KC. JCI Insight. 2023 Jun 8; 2023 Jun 8. PMID: 37097758.", + "The Plasma Cell Infiltrate Populating the Muscle Tissue of Patients with Inclusion Body Myositis Features Distinct B Cell Receptor Repertoire Properties. Jiang R, Roy B, Wu Q, Mohanty S, Nowak RJ, Shaw AC, Kleinstein SH, O'Connor KC. Immunohorizons. 2023 May 1. PMID: 37171806.", + "Clinicoserological insights into patients with immune checkpoint inhibitor-induced myasthenia gravis. Masi G, Pham MC, Karatz T, Oh S, Payne AS, Nowak RJ, Howard JF Jr, Guptill JT, Juel VC, O'Connor KC. Ann Clin Transl Neurol. 2023 May; 2023 Mar 16. PMID: 36924454.", + "Randomized Double-Blind Placebo-Controlled Trial of the Corticosteroid-Sparing Effects of Immunoglobulin in Myasthenia Gravis. Bril V, Szczudlik A, Vaitkus A, Rozsa C, Kostera-Pruszczyk A, Hon P, Bednarik J, Tyblova M, Köhler W, Toomsoo T, Nowak RJ, Mozaffar T, Freimer ML, Nicolle MW, Magnus T, Pulley MT, Rivner M, Dimachkie MM, Distad BJ, Pascuzzi RM, Babiar D, Lin J, Querolt Coll M, Griffin R, Mondou E. Neurology. 2023 Feb 14; 2022 Oct 21. PMID: 36270895.", + "Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy. Fichtner ML, Hoehn KB, Ford EE, Mane-Damas M, Oh S, Waters P, Payne AS, Smith ML, Watson CT, Losen M, Martinez-Martinez P, Nowak RJ, Kleinstein SH, O'Connor KC. Acta Neuropathol Commun. 2022 Oct 28; 2022 Oct 28. PMID: 36307868.", + "Myasthenia Gravis in the Setting of Immune Checkpoint Inhibitor Therapy: Practical Considerations and Opinion-Based Approach to Acute Management. Zubair AS, Roy B, Baehring JM, Nowak RJ. Cureus. 2022 Oct; 2022 Oct 24. PMID: 36439604.", + "A preliminary, prospective study of peripheral neuropathy and cognitive function in patients with breast cancer during taxane therapy. Ibrahim EY, Munshani S, Domenicano I, Rodwin R, Nowak RJ, Pusztai L, Lustberg M, Ehrlich BE. PLoS One. 2022; 2022 Oct 7. PMID: 36206298.", + "Heterogeneity of Acetylcholine Receptor Autoantibody-Mediated Complement Activity in Patients With Myasthenia Gravis. Obaid AH, Zografou C, Vadysirisack DD, Munro-Sheldon B, Fichtner ML, Roy B, Philbrick WM, Bennett JL, Nowak RJ, O'Connor KC. Neurol Neuroimmunol Neuroinflamm. 2022 Jul; 2022 Apr 26. PMID: 35473886.", + "The clinical need for clustered AChR cell-based assay testing of seronegative MG. Masi G, Li Y, Karatz T, Pham MC, Oxendine SR, Nowak RJ, Guptill JT, O'Connor KC. J Neuroimmunol. 2022 Jun 15; 2022 Mar 25. PMID: 35366559.", + "Reliability of patient self-reports to clinician-assigned functional scores of inclusion body myositis. Roy B, Zubair A, Petschke K, O'Connor KC, Paltiel AD, Nowak RJ. J Neurol Sci. 2022 May 15; 2022 Mar 15. PMID: 35344793.", + "Myasthenia gravis complement activity is independent of autoantibody titer and disease severity. Fichtner ML, Hoarty MD, Vadysirisack DD, Munro-Sheldon B, Nowak RJ, O'Connor KC. PLoS One. 2022; 2022 Mar 15. PMID: 35290370.", + "Phase 2 Trial of Rituximab in Acetylcholine Receptor Antibody-Positive Generalized Myasthenia Gravis: The BeatMG Study. Nowak RJ, Coffey CS, Goldstein JM, Dimachkie MM, Benatar M, Kissel JT, Wolfe GI, Burns TM, Freimer ML, Nations S, Granit V, Smith AG, Richman DP, Ciafaloni E, Al-Lozi MT, Sams LA, Quan D, Ubogu E, Pearson B, Sharma A, Yankey JW, Uribe L, Shy M, Amato AA, Conwit R, O'Connor KC, Hafler DA, Cudkowicz ME, Barohn RJ. Neurology. 2022 Jan 25; 2022 Jan 25. PMID: 34857535.", + "Eculizumab in refractory generalized myasthenia gravis previously treated with rituximab: subgroup analysis of REGAIN and its extension study. Siddiqi ZA, Nowak RJ, Mozaffar T, O'Brien F, Yountz M, Patti F. Muscle Nerve. 2021 Dec; 2021 Oct 14. PMID: 34590717.", + "Elevated N-Linked Glycosylation of IgG V Regions in Myasthenia Gravis Disease Subtypes. Mandel-Brehm C, Fichtner ML, Jiang R, Winton VJ, Vazquez SE, Pham MC, Hoehn KB, Kelleher NL, Nowak RJ, Kleinstein SH, Wilson MR, DeRisi JL, O'Connor KC. J Immunol. 2021 Oct 15; 2021 Sep 20. PMID: 34544801.", + "Telemedicine visits in myasthenia gravis: Expert guidance and the Myasthenia Gravis Core Exam (MG-CE). Guidon AC, Muppidi S, Nowak RJ, Guptill JT, Hehir MK, Ruzhansky K, Burton LB, Post D, Cutter G, Conwit R, Mejia NI, Kaminski HJ, Howard JF Jr. Muscle Nerve. 2021 Sep; 2021 Jul 7. PMID: 33959997.", + "Influenza vaccination in autoimmune neuromuscular diseases: A survey of current practices and perceptions. Roy B, Litchman T, Torabi T, Nowak RJ. Muscle Nerve. 2021 Jun; 2021 Mar 23. PMID: 33711167.", + "Electronic health record derived-impact of COVID-19 on myasthenia gravis. Roy B, Kovvuru S, Nalleballe K, Onteddu SR, Nowak RJ. J Neurol Sci. 2021 Apr 15; 2021 Feb 20. PMID: 33639420.", + "Neurotoxicities associated with immune checkpoint inhibitor therapy. Duong SL, Barbiero FJ, Nowak RJ, Baehring JM. J Neurooncol. 2021 Apr; 2021 Jan 17. PMID: 33454891.", + "Immunosuppression in chronic autoimmune neurological disorders during the COVID-19 pandemic. Kovvuru S, Nalleballe K, Onteddu SR, Sharma R, Jasti M, Kapoor N, Veerapaneni K, Yadala S, Dandu V, Archer R, Nowak RJ, Roy B. J Neurol Sci. 2021 Jan 15; 2020 Nov 27. PMID: 33256952.", + "Affinity maturation is required for pathogenic monovalent IgG4 autoantibody development in myasthenia gravis. Fichtner ML, Vieni C, Redler RL, Kolich L, Jiang R, Takata K, Stathopoulos P, Suarez PA, Nowak RJ, Burden SJ, Ekiert DC, O'Connor KC. J Exp Med. 2020 Dec 7. PMID: 32820331.", + "COVID-19-associated risks and effects in myasthenia gravis (CARE-MG). Muppidi S, Guptill JT, Jacob S, Li Y, Farrugia ME, Guidon AC, Tavee JO, Kaminski H, Howard JF Jr, Cutter G, Wiendl H, Maas MB, Illa I, Mantegazza R, Murai H, Utsugisawa K, Nowak RJ. Lancet Neurol. 2020 Dec. PMID: 33212055.", + "Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis. Jiang R, Hoehn KB, Lee CS, Pham MC, Homer RJ, Detterbeck FC, Aban I, Jacobson L, Vincent A, Nowak RJ, Kaminski HJ, Kleinstein SH, O'Connor KC. Proc Natl Acad Sci U S A. 2020 Dec 1; 2020 Nov 16. PMID: 33199596.", + "Concomitant Immunosuppressive Therapy Use in Eculizumab-Treated Adults With Generalized Myasthenia Gravis During the REGAIN Open-Label Extension Study. Nowak RJ, Muppidi S, Beydoun SR, O'Brien FL, Yountz M, Howard JF Jr. Front Neurol. 2020; 2020 Nov 24. PMID: 33329303.", + "Eculizumab in Acute Motor Axonal Neuropathy: An Ethical Application of an Off-Label Indication. Roy B, Nowak RJ. J Clin Neuromuscul Dis. 2020 Sep. PMID: 32833730.", + "Clinical features of LRP4/agrin-antibody-positive myasthenia gravis: A multicenter study. Rivner MH, Quarles BM, Pan JX, Yu Z, Howard JF Jr, Corse A, Dimachkie MM, Jackson C, Vu T, Small G, Lisak RP, Belsh J, Lee I, Nowak RJ, Baute V, Scelsa S, Fernandes JA, Simmons Z, Swenson A, Barohn R, Sanka RB, Gooch C, Ubogu E, Caress J, Pasnoor M, Xu H, Mei L. Muscle Nerve. 2020 Sep; 2020 Jun 10. PMID: 32483837.", + "Single-cell repertoire tracing identifies rituximab-resistant B cells during myasthenia gravis relapses. Jiang R, Fichtner ML, Hoehn KB, Pham MC, Stathopoulos P, Nowak RJ, Kleinstein SH, O'Connor KC. JCI Insight. 2020 Jul 23; 2020 Jul 23. PMID: 32573488.", + "Teleneurology during the COVID-19 pandemic: A step forward in modernizing medical care. Roy B, Nowak RJ, Roda R, Khokhar B, Patwa HS, Lloyd T, Rutkove SB. J Neurol Sci. 2020 Jul 15; 2020 May 21. PMID: 32460041.", + "Exploring outcomes and characteristics of myasthenia gravis: Rationale, aims and design of registry - The EXPLORE-MG registry. Anil R, Kumar A, Alaparthi S, Sharma A, Nye JL, Roy B, O'Connor KC, Nowak RJ. J Neurol Sci. 2020 Jul 15; 2020 Apr 16. PMID: 32388060.", + "Autoimmune Pathology in Myasthenia Gravis Disease Subtypes Is Governed by Divergent Mechanisms of Immunopathology. Fichtner ML, Jiang R, Bourke A, Nowak RJ, O'Connor KC. Front Immunol. 2020; 2020 May 27. PMID: 32547535.", + "Guidance for the management of myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) during the COVID-19 pandemic. Jacob S, Muppidi S, Guidon A, Guptill J, Hehir M, Howard JF Jr, Illa I, Mantegazza R, Murai H, Utsugisawa K, Vissing J, Wiendl H, Nowak RJ. J Neurol Sci. 2020 May 15; 2020 Mar 25. PMID: 32247193.", + "Response to eculizumab in patients with myasthenia gravis recently treated with chronic IVIg: a subgroup analysis of REGAIN and its open-label extension study. Jacob S, Murai H, Utsugisawa K, Nowak RJ, Wiendl H, Fujita KP, O'Brien F, Howard JF Jr. Ther Adv Neurol Disord. 2020; 2020 May 6. PMID: 32426038.", + "Clinical Effects of the Self-administered Subcutaneous Complement Inhibitor Zilucoplan in Patients With Moderate to Severe Generalized Myasthenia Gravis: Results of a Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial. Howard JF Jr, Nowak RJ, Wolfe GI, Freimer ML, Vu TH, Hinton JL, Benatar M, Duda PW, MacDougall JE, Farzaneh-Far R, Kaminski HJ, Barohn R, Dimachkie M, Pasnoor M, Farmakidis C, Liu T, Colgan S, Benatar MG, Bertorini T, Pillai R, Henegar R, Bromberg M, Gibson S, Janecki T, Freimer M, Elsheikh B, Matisak P, Genge A, Guidon A, David W, Habib AA, Mathew V, Mozaffar T, Hinton JL, Hewitt W, Barnett D, Sullivan P, Ho D, Howard JF Jr, Traub RE, Chopra M, Kaminski HJ, Aly R, Bayat E, Abu-Rub M, Khan S, Lange D, Holzberg S, Khatri B, Lindman E, Olapo T, Sershon LM, Lisak RP, Bernitsas E, Jia K, Malik R, Lewis-Collins TD, Nicolle M, Nowak RJ, Sharma A, Roy B, Nye J, Pulley M, Berger A, Shabbir Y, Sachdev A, Patterson K, Siddiqi Z, Sivak M, Bratton J, Small G, Kohli A, Fetter M, Vu T, Lam L, Harvey B, Wolfe GI, Silvestri N, Patrick K, Zakalik K, Duda PW, MacDougall J, Farzaneh-Far R, Pontius A, Hoarty M. JAMA Neurol. 2020 May 1. PMID: 32065623.", + "Differential response to rituximab in anti-AChR and anti-MuSK positive myasthenia gravis patients: a single-center retrospective study. Litchman T, Roy B, Kumar A, Sharma A, Njike V, Nowak RJ. J Neurol Sci. 2020 Apr 15; 2020 Jan 18. PMID: 32028072.", + "Electrical impedance myography as a biomarker of inclusion body myositis: A cross-sectional study. Roy B, Rutkove SB, Nowak RJ. Clin Neurophysiol. 2020 Feb; 2019 Dec 6. PMID: 31865137.", + "Clinical Reasoning: Progressive proximal weakness in a 56-year-old man with bone pain. Torabi T, Huttner A, Nowak RJ, Roy B. Neurology. 2019 Nov 19. PMID: 31740511.", + "Neuropathy with vascular endothelial growth factor receptor tyrosine kinase inhibitors: A meta-analysis. Roy B, Das A, Ashish K, Bandyopadhyay D, Maiti A, Chakraborty S, Stone ME, Philpotts LL, Nowak RJ, Patwa HS. Neurology. 2019 Jul 9; 2019 Jun 5. PMID: 31167931.", + "Long-term safety and efficacy of eculizumab in generalized myasthenia gravis. Muppidi S, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel JT, Nowak RJ, Andersen H, Casasnovas C, de Bleecker JL, Vu TH, Mantegazza R, O'Brien FL, Wang JJ, Fujita KP, Howard JF Jr. Muscle Nerve. 2019 Jul; 2019 Mar 8. PMID: 30767274.", + "Characterization of pathogenic monoclonal autoantibodies derived from muscle-specific kinase myasthenia gravis patients. Takata K, Stathopoulos P, Cao M, Mané-Damas M, Fichtner ML, Benotti ES, Jacobson L, Waters P, Irani SR, Martinez-Martinez P, Beeson D, Losen M, Vincent A, Nowak RJ, O'Connor KC. JCI Insight. 2019 Jun 20; 2019 Jun 20. PMID: 31217355.", + "Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity. Stathopoulos P, Chastre A, Waters P, Irani S, Fichtner ML, Benotti ES, Guthridge JM, Seifert J, Nowak RJ, Buckner JH, Holers VM, James JA, Hafler DA, O'Connor KC. J Immunol. 2019 Apr 15; 2019 Mar 1. PMID: 30824481.", + "Thymectomy may not be associated with clinical improvement in MuSK myasthenia gravis. Clifford KM, Hobson-Webb LD, Benatar M, Burns TM, Barnett C, Silvestri NJ, Howard JF Jr, Visser A, Crum BA, Nowak R, Beekman R, Kumar A, Ruzhansky K, Chen IA, Pulley MT, Laboy SM, Fellman MA, Howard DB, Kolb NA, Greene SM, Pasnoor M, Dimachkie MM, Barohn RJ, Hehir MK. Muscle Nerve. 2019 Apr; 2019 Jan 14. PMID: 30575980.", + "B cells in the pathophysiology of myasthenia gravis. Yi JS, Guptill JT, Stathopoulos P, Nowak RJ, O'Connor KC. Muscle Nerve. 2018 Feb; 2017 Sep 30. PMID: 28940642.", + "Mechanisms underlying B cell immune dysregulation and autoantibody production in MuSK myasthenia gravis. Stathopoulos P, Kumar A, Heiden JAV, Pascual-Goñi E, Nowak RJ, O'Connor KC. Ann N Y Acad Sci. 2018 Jan. PMID: 29381221.", + "Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study. Howard JF Jr, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel JT, Muppidi S, Nowak RJ, O'Brien F, Wang JJ, Mantegazza R. Lancet Neurol. 2017 Dec; 2017 Oct 20. PMID: 29066163.", + "Rituximab as treatment for anti-MuSK myasthenia gravis: Multicenter blinded prospective review. Hehir MK, Hobson-Webb LD, Benatar M, Barnett C, Silvestri NJ, Howard JF Jr, Howard D, Visser A, Crum BA, Nowak R, Beekman R, Kumar A, Ruzhansky K, Chen IA, Pulley MT, LaBoy SM, Fellman MA, Greene SM, Pasnoor M, Burns TM. Neurology. 2017 Sep 5; 2017 Aug 11. PMID: 28801338.", + "Immunoglobulin therapy in the treatment of multifocal motor neuropathy. Kumar A, Patwa HS, Nowak RJ. J Neurol Sci. 2017 Apr 15; 2017 Jan 25. PMID: 28320129.", + "Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing. Vander Heiden JA, Stathopoulos P, Zhou JQ, Chen L, Gilbert TJ, Bolen CR, Barohn RJ, Dimachkie MM, Ciafaloni E, Broering TJ, Vigneault F, Nowak RJ, Kleinstein SH, O'Connor KC. J Immunol. 2017 Feb 15; 2017 Jan 13. PMID: 28087666.", + "Durability of the Rituximab Response in Acetylcholine Receptor Autoantibody-Positive Myasthenia Gravis. Robeson KR, Kumar A, Keung B, DiCapua DB, Grodinsky E, Patwa HS, Stathopoulos PA, Goldstein JM, O'Connor KC, Nowak RJ. JAMA Neurol. 2017 Jan 1. PMID: 27893014.", + "Can a Point-of-Care Troponin I Assay be as Good as a Central Laboratory Assay? A MIDAS Investigation. Peacock WF, Diercks D, Birkhahn R, Singer AJ, Hollander JE, Nowak R, Safdar B, Miller CD, Peberdy M, Counselman F, Chandra A, Kosowsky J, Neuenschwander J, Schrock J, Lee-Lewandrowski E, Arnold W, Nagurney J. Ann Lab Med. 2016 Sep. PMID: 27374704.", + "Compromised fidelity of B-cell tolerance checkpoints in AChR and MuSK myasthenia gravis. Lee JY, Stathopoulos P, Gupta S, Bannock JM, Barohn RJ, Cotzomi E, Dimachkie MM, Jacobson L, Lee CS, Morbach H, Querol L, Shan JL, Vander Heiden JA, Waters P, Vincent A, Nowak RJ, O'Connor KC. Ann Clin Transl Neurol. 2016 Jun; 2016 Apr 27. PMID: 27547772.", + "Exacerbation of myasthenia gravis in a patient with melanoma treated with pembrolizumab. Lau KH, Kumar A, Yang IH, Nowak RJ. Muscle Nerve. 2016 Jun; 2016 May 19. PMID: 27065302.", + "Autoreactive T Cells from Patients with Myasthenia Gravis Are Characterized by Elevated IL-17, IFN-γ, and GM-CSF and Diminished IL-10 Production. Cao Y, Amezquita RA, Kleinstein SH, Stathopoulos P, Nowak RJ, O'Connor KC. J Immunol. 2016 Mar 1; 2016 Jan 29. PMID: 26826242.", + "Previously undiagnosed fatal familial haemophagocytic lymphohistiocytosis in a 24-year-old woman. Barmettler S, Nowak RJ, Parker T, Price C. BMJ Case Rep. 2016 Feb 22; 2016 Feb 22. PMID: 26903364.", + "Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine. Burns TM, Smith GA, Allen JA, Amato AA, Arnold WD, Barohn R, Benatar M, Bird SJ, Bromberg M, Chahin N, Ciafaloni E, Cohen JA, Corse A, Crum BA, David WS, Dimberg E, Sousa EA, Donofrio PD, Dyck PJ, Engel AG, Ensrud ER, Ferrante M, Freimer M, Gable KL, Gibson S, Gilchrist JM, Goldstein JM, Gooch CL, Goodman BP, Gorelov D, Gospe SM Jr, Goyal NA, Guidon AC, Guptill JT, Gutmann L, Gutmann L, Gwathmey K, Harati Y, Harper CM Jr, Hehir MK, Hobson-Webb LD, Howard JF Jr, Jackson CE, Johnson N, Jones SM, Juel VC, Kaminski HJ, Karam C, Kennelly KD, Khella S, Khoury J, Kincaid JC, Kissel JT, Kolb N, Lacomis D, Ladha S, Larriviere D, Lewis RA, Li Y, Litchy WJ, Logigian E, Lou JS, MacGowen DJ, Maselli R, Massey JM, Mauermann ML, Mathews KD, Meriggioli MN, Miller RG, Moon JS, Mozaffar T, Nations SP, Nowak RJ, Ostrow LW, Pascuzzi RM, Peltier A, Ruzhansky K, Richman DP, Ross MA, Rubin DI, Russell JA, Sachs GM, Salajegheh MK, Saperstein DS, Scelsa S, Selcen D, Shaibani A, Shieh PB, Silvestri NJ, Singleton JR, Smith BE, So YT, Solorzano G, Sorenson EJ, Srinivasen J, Tavee J, Tawil R, Thaisetthawatkul P, Thornton C, Trivedi J, Vernino S, Wang AK, Webb TA, Weiss MD, Windebank AJ, Wolfe GI. Muscle Nerve. 2016 Feb; 2015 Dec 21. PMID: 26662952.", + "Current and future immunotherapy targets in autoimmune neurology. Hu MY, Stathopoulos P, O'connor KC, Pittock SJ, Nowak RJ. Handb Clin Neurol. 2016. PMID: 27112694.", + "Relationship Between Cerebrospinal Fluid Protein Levels and Electrophysiologic Abnormalities in Guillain-Barré Syndrome. DiCapua DB, Lakraj AA, Nowak RJ, Robeson K, Goldstein J, Patwa H. J Clin Neuromuscul Dis. 2015 Dec. PMID: 26583489.", + "Demographic and clinical features of inclusion body myositis in North America. Paltiel AD, Ingvarsson E, Lee DK, Leff RL, Nowak RJ, Petschke KD, Richards-Shubik S, Zhou A, Shubik M, O'Connor KC. Muscle Nerve. 2015 Oct; 2015 Feb 17. PMID: 25557419.", + "Cardioembolic stroke: practical considerations for patient risk management and secondary prevention. Amin H, Nowak RJ, Schindler JL. Postgrad Med. 2014 Jan. PMID: 24393752.", + "Long-term benefit of rituximab in MuSK autoantibody myasthenia gravis patients. Keung B, Robeson KR, DiCapua DB, Rosen JB, O'Connor KC, Goldstein JM, Nowak RJ. J Neurol Neurosurg Psychiatry. 2013 Dec; 2013 Jun 12. PMID: 23761915.", + "Clinical characteristics of refractory myasthenia gravis patients. Suh J, Goldstein JM, Nowak RJ. Yale J Biol Med. 2013 Jun; 2013 Jun 13. PMID: 23766745.", + "Novel mutations in the CLCN1 gene of myotonia congenita: 2 case reports. Lakraj AA, Miller G, Vortmeyer AO, Khokhar B, Nowak RJ, DiCapua DB. Yale J Biol Med. 2013 Mar; 2013 Mar 12. PMID: 23483815.", + "Acute central retinal artery occlusion treated with intravenous recombinant tissue plasminogen activator. Nowak RJ, Amin H, Robeson K, Schindler JL. J Stroke Cerebrovasc Dis. 2012 Nov; 2012 Feb 18. PMID: 22349707.", + "Autoantibodies produced at the site of tissue damage provide evidence of humoral autoimmunity in inclusion body myositis. Ray A, Amato AA, Bradshaw EM, Felice KJ, DiCapua DB, Goldstein JM, Lundberg IE, Nowak RJ, Ploegh HL, Spooner E, Wu Q, Willis SN, O'Connor KC. PLoS One. 2012; 2012 Oct 5. PMID: 23071619.", + "Response of patients with refractory myasthenia gravis to rituximab: a retrospective study. Nowak RJ, Dicapua DB, Zebardast N, Goldstein JM. Ther Adv Neurol Disord. 2011 Sep. PMID: 22010039.", + "", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Clinical NLP Lab", + "lab_url": "https://medicine.yale.edu/lab/clinical-nlp/", + "research_bio": "INFORMATION FOR Our lab is dedicated to advancing natural language processing (NLP) through the development of novel methods, robust software, and real-world applications across a range of biomedical texts, including clinical notes, scientific literature, and social media. These three areas are closely interconnected: innovative methods inform the creation of widely used software; that software supports clinical applications; and insights from those applications highlight new challenges, guiding the development of future methods. Together, they form a dynamic and collaborative ecosystem that drives our research in clinical NLP. Copy Link Copy Link Copy Link \"Cost Effective Agent-Driven Rare Disease Discovery within Electronic Health Record Systems\" Talk Title:RDMA: Cost Effective Agent-Driven Rare Disease Discovery within Electronic Health Record Systems Abstract:Rare diseases affect 1 in 10 Americans, yet standard ICD coding systems fail to capture these conditions in electronic health records (EHR), leaving crucial information about rare diseases, their clinical presentations, and phenotypic patterns buried in unstructured clinical notes. Current automated extraction approaches struggle with medical abbreviations, miss implicit phenotype mentions, raise privacy concerns through cloud processing, and lack the clinical reasoning abilities needed for accurate identification of rare disease presentations in human patients. We present Rare Disease Mining Agents (RDMA), a framework that mirrors how clinical experts approach rare disease identification by systematically connecting clinical observations directly to standardized ontologies like Orphanet and Human Phenotype Ontology. RDMA handles clinical abbreviations, recognizes implicit phenotype patterns, and applies contextual reasoning locally on standard hardware to extract and code rare disease information with supporting textual evidence. This approach reduces privacy risks while improving F1 performance by over 30\\% and decreasing inference costs 10-fold, achieving high precision (89\\%) in rare disease mining and coding. By enabling clinicians to access systematically coded rare disease information with explicit evidence from EHR systems without cloud-based privacy risks, RDMA supports identification and documentation of rare conditions. Available at https://github.com/jhnwu3/RDMA. John Wu is a a Ph.D student in the CS department at the University of Illinois, currently advised byProfessor Jimeng Sun. His main focus is on building agentic systems for healthcare settings, whether that be low resource (i.e rare diseases), interpretability, or clinical predictive modeling. He actively maintainsPyHealth, and leads a community of open-source researchers, trying to build more reproducible healthcare solutions. His work is currently supported by the NSF GRFP. Agentic AI for Clinical Data: Structuring, Reasoning, and Scaling Biomedical Language Models Large language models hold enormous potential for transforming healthcare, but their deployment is often bottlenecked by unstructured data, fragmented pipelines, and inconsistent model-data alignment.Nimblemind.AIaddresses these challenges with an agentic AI framework that automates the full clinical data lifecycle from ingestion and de-identification to inference and interpretability. Building on the paper, “Agentic AI Framework for End-to-End Medical Data Inference”, the talk will discuss how specialized agents collaborate to process multimodal data, link structured EHR fields with clinical narratives, and route tasks to the most appropriate foundation or domain model. This framework demonstrates how autonomous agent coordination can turn LLMs into operational tools to contextualize patient records, ensure reproducibility, and generate transparent explanations of model outputs. The talk will wrap up with a demo of Nimblemind.AI's new platform, NimbleLabs, where users can add a simple clinical description and relevant data to generate a fully operational, specialty-specific predictive model ready for real-world clinical environments. Navin Kumar, PhD is the co-founder of Nimblemind.AI, a company building agentic AI systems to make clinical data interoperable and actionable. Born and raised in Singapore, Kumar earned their PhD at Yale University underNicholas Christakis, publishing over 60 papers and securing more than $1M in research funding on AI-driven approaches to population health. Before founding Nimblemind.AI, they led data science and AI initiatives at NYC Health + Hospitals, the nation’s largest public healthcare system, and deployed predictive models that improved chronic disease screening and reduced missed appointments across over one million patients. Witnessing firsthand how data inefficiency limits equitable care, Kumar launched Nimblemind.AI to build scalable, transparent AI infrastructure that improves outcomes, especially for minority populations. \"From Compound Figures to Composite Understanding\" From Compound Figures to Composite Understanding:Developing a Multi-Modal LLM from Biomedical Literature with Medical Multiple-Image Benchmarking and Validation In healthcare, disease diagnostics and longitudinal patient monitoring require clinicians to synthesize information across multiple images from different modalities or time points, yet this multi-image reasoning remains a significant gap for most current multi-modal LLMs. This capability gap persists due to a critical bottleneck: the lack of large-scale, high-quality annotated training data for medical multi-image understanding. This study aims to address this scarcity by leveraging compound figures from biomedical literature. We devised a novel five-stage, context-aware instruction generation pipeline to create the PMC-MI-Dataset comprising over 260,000 compound images, and subsequently developed M³LLM, a medical multi-image multi-modal LLM. For a comprehensive evaluation, we also constructed the expert-validated PMC-MI-Bench. M³LLM significantly outperforms state-of-the-art general-purpose and specialized MLLMs, achieving superior performance on diverse tasks of the PMC-MI-Bench and public benchmarks like OmniMedVQA and MMMU-Med. Furthermore, clinical validation on the MIMIC longitudinal chest X-ray dataset confirms its superior performance in real-world tasks, including disease diagnosis and progression prediction. Our study establishes a scalable paradigm for this task, and the model, dataset, and benchmark will be publicly released. \"Opportunities and Pitfalls of Large Language Models in Digestive Diseases\" The evidence base for LLMs in digestive diseases shows wide performance variability, underscoring safety risks and the need for rigorous evaluation. In this talk,Mauro Giuffrè, MDwill overview his main contributions in the field: a systematic review that quantified accuracy ranges and highlighted methodological gaps; a guideline-grounded study showing that retrieval-augmented and fine-tuned GPT-4 markedly improve open-ended answer quality and treatment selection in patients with Hepatitis C Virus; an “expert-of-experts” verification framework (EVAL) that aligns automated grading with human experts and boosts correctness via rejection sampling; and a randomized simulation trial (GutGPT) revealing that better usability does not automatically translate into adoption, pointing to trust and workflow integration as key levers for impact. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Cohn Lab", + "lab_url": "https://medicine.yale.edu/lab/cohn/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/cohn/publications", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Pulmonary, Critical Care & Sleep Medicine /", + "Research", + "Contact Us", + "Publications", + "News", + "Lab Members", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Publications", + "News", + "Lab Members", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma. Gautam S, Chu JH, Cohen AJ, Kaur R, Lee S, Wilson G, Liu Q, Gomez J, Rajaveen H, Yan X, Cohn L, Clark BJ, Chupp GL. Allergy. 2023 Dec; 2023 Oct 24. PMID: 37874609.", + "Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19. Liu Y, Rajeevan H, Simonov M, Lee S, Wilson FP, Desir GV, Vinetz JM, Yan X, Wang Z, Clark BJ, Possick JD, Price C, Lutchmansingh DD, Ortega H, Zaeh S, Gomez JV, Cohn L, Gautam S, Chupp GL. J Allergy Clin Immunol Pract. 2023 Nov; 2023 Jul 14. PMID: 37454926.", + "The long-term effect of dupilumab on dyspnea, sleep, and activity in oral corticosteroid-dependent severe asthma. Sher LD, Passalacqua G, Taillé C, Cohn L, Daizadeh N, Pandit-Abid N, Soler X, Khodzhayev A, Jacob-Nara JA, Deniz Y, Rowe PJ, Nag A, Zhang Y. Ann Allergy Asthma Immunol. 2023 Mar; 2022 Dec 9. PMID: 36509407.", + "Patient Preferences for Attributes of Biologic Treatments in Moderate to Severe Asthma: A Discrete Choice Experiment Study. Yang M, Chao J, Fillbrunn M, Mallya UG, Wang MJ, Franke L, Cohn L, Kamat S. Patient Prefer Adherence. 2022; 2022 Sep 23. PMID: 36176349.", + "Can asthma biologics change the course of disease and induce drug-free remission? Cohn L. J Allergy Clin Immunol. 2022 Jul; 2022 Apr 18. PMID: 35447228.", + "SPLUNC1: a novel marker of cystic fibrosis exacerbations. Khanal S, Webster M, Niu N, Zielonka J, Nunez M, Chupp G, Slade MD, Cohn L, Sauler M, Gomez JL, Tarran R, Sharma L, Dela Cruz CS, Egan M, Laguna T, Britto CJ. Eur Respir J. 2021 Nov; 2021 Nov 11. PMID: 33958427.", + "A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY: Learning From the Past, Looking to the Future. Lutchmansingh DD, Knauert MP, Antin-Ozerkis DE, Chupp G, Cohn L, Dela Cruz CS, Ferrante LE, Herzog EL, Koff J, Rochester CL, Ryu C, Singh I, Tickoo M, Winks V, Gulati M, Possick JD. Chest. 2021 Mar; 2020 Nov 4. PMID: 33159907.", + "A Network of Sputum MicroRNAs Is Associated with Neutrophilic Airway Inflammation in Asthma. Gomez JL, Chen A, Diaz MP, Zirn N, Gupta A, Britto C, Sauler M, Yan X, Stewart E, Santerian K, Grant N, Liu Q, Fry R, Rager J, Cohn L, Alexis N, Chupp GL. Am J Respir Crit Care Med. 2020 Jul 1. PMID: 32255668.", + "An endothelial microRNA-1-regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitis. Korde A, Ahangari F, Haslip M, Zhang X, Liu Q, Cohn L, Gomez JL, Chupp G, Pober JS, Gonzalez A, Takyar SS. J Allergy Clin Immunol. 2020 Feb. PMID: 32035607.", + "BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation. Britto CJ, Niu N, Khanal S, Huleihel L, Herazo-Maya JD, Thompson A, Sauler M, Slade MD, Sharma L, Dela Cruz CS, Kaminski N, Cohn LE. Am J Physiol Lung Cell Mol Physiol. 2019 Feb 1; 2018 Nov 21. PMID: 30461288.", + "Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair. Jin H, Ciechanowicz AK, Kaplan AR, Wang L, Zhang PX, Lu YC, Tobin RE, Tobin BA, Cohn L, Zeiss CJ, Lee PJ, Bruscia EM, Krause DS. Am J Physiol Lung Cell Mol Physiol. 2018 May 1; 2018 Jan 18. PMID: 29345196.", + "Characterisation of asthma subgroups associated with circulating YKL-40 levels. Gomez JL, Yan X, Holm CT, Grant N, Liu Q, Cohn L, Nezgovorova V, Meyers DA, Bleecker ER, Crisafi GM, Jarjour NN, Rogers L, Reibman J, Chupp GL. Eur Respir J. 2017 Oct; 2017 Oct 12. PMID: 29025889.", + "Long-term outcomes of bronchial thermoplasty in subjects with severe asthma: a comparison of 3-year follow-up results from two prospective multicentre studies. Chupp G, Laviolette M, Cohn L, McEvoy C, Bansal S, Shifren A, Khatri S, Grubb GM, McMullen E, Strauven R, Kline JN. Eur Respir J. 2017 Aug; 2017 Aug 31. PMID: 28860266.", + "A novel pathway-based distance score enhances assessment of disease heterogeneity in gene expression. Yan X, Liang A, Gomez J, Cohn L, Zhao H, Chupp GL. BMC Bioinformatics. 2017 Jun 20; 2017 Jun 20. PMID: 28637421.", + "Sputum Gene Expression of IL-13 Receptor α2 Chain Correlates with Airflow Obstruction and Helper T-Cell Type 2 Inflammation in Asthma. Nezgovorova V, Liu Q, Hu B, Villalobos JL, Yan X, Niu N, Holm C, Grant NP, Marone S, Ravage-Mass L, Lee CG, Elias JA, Cohn L, Chupp GL. Ann Am Thorac Soc. 2016 Mar. PMID: 27027964.", + "Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma. Yan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL. Ann Am Thorac Soc. 2016 Mar. PMID: 27027945.", + "Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40. Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N, Cohn L, Chupp GL. J Allergy Clin Immunol. 2015 Jul; 2015 Jan 13. PMID: 25592985.", + "Bactericidal/Permeability-increasing protein fold-containing family member A1 in airway host protection and respiratory disease. Britto CJ, Cohn L. Am J Respir Cell Mol Biol. 2015 May. PMID: 25265466.", + "Update in asthma 2013. Cohn L, Woodruff PG. Am J Respir Crit Care Med. 2014 Jun 15. PMID: 24930529.", + "VEGF controls lung Th2 inflammation via the miR-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin axis. Takyar S, Vasavada H, Zhang JG, Ahangari F, Niu N, Liu Q, Lee CG, Cohn L, Elias JA. J Exp Med. 2013 Sep 23; 2013 Sep 16. PMID: 24043765.", + "Short palate, lung, and nasal epithelial clone-1 is a tightly regulated airway sensor in innate and adaptive immunity. Britto CJ, Liu Q, Curran DR, Patham B, Dela Cruz CS, Cohn L. Am J Respir Cell Mol Biol. 2013 Jun. PMID: 23470624.", + "Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells. Chatterjee B, Smed-Sörensen A, Cohn L, Chalouni C, Vandlen R, Lee BC, Widger J, Keler T, Delamarre L, Mellman I. Blood. 2012 Sep 6; 2012 Jul 12. PMID: 22791285.", + "IFN-γ acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease. Mitchell C, Provost K, Niu N, Homer R, Cohn L. J Immunol. 2011 Oct 1; 2011 Aug 26. PMID: 21873527.", + "Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC. J Exp Med. 2010 Nov 22; 2010 Oct 25. PMID: 20975041.", + "Advances in mucous cell metaplasia: a plug for mucus as a therapeutic focus in chronic airway disease. Curran DR, Cohn L. Am J Respir Cell Mol Biol. 2010 Mar; 2009 Jun 11. PMID: 19520914.", + "Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5. Wang Z, Kumamoto Y, Wang P, Gan X, Lehmann D, Smrcka AV, Cohn L, Iwasaki A, Li L, Wu D. J Biol Chem. 2009 Oct 16; 2009 Aug 27. PMID: 19713215.", + "Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation. Chapoval SP, Lee CG, Tang C, Keegan AD, Cohn L, Bottomly K, Elias JA. Clin Immunol. 2009 Sep; 2009 Jun 24. PMID: 19553159.", + "Cutting edge: Limiting MHC class II expression to dendritic cells alters the ability to develop Th2- dependent allergic airway inflammation. Niu N, Laufer T, Homer RJ, Cohn L. J Immunol. 2009 Aug 1; 2009 Jul 13. PMID: 19596982.", + "A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. Proc Natl Acad Sci U S A. 2009 Jun 2; 2009 May 19. PMID: 19458046.", + "Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. Lee CG, Hartl D, Lee GR, Koller B, Matsuura H, Da Silva CA, Sohn MH, Cohn L, Homer RJ, Kozhich AA, Humbles A, Kearley J, Coyle A, Chupp G, Reed J, Flavell RA, Elias JA. J Exp Med. 2009 May 11; 2009 May 4. PMID: 19414556.", + "TRPA1 is a major oxidant sensor in murine airway sensory neurons. Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, Jordt SE. J Clin Invest. 2008 May. PMID: 18398506.", + "A novel pathway that regulates inflammatory disease in the respiratory tract. Niu N, Le Goff MK, Li F, Rahman M, Homer RJ, Cohn L. J Immunol. 2007 Mar 15. PMID: 17339484.", + "Toll-like receptor 4 deficiency causes pulmonary emphysema. Zhang X, Shan P, Jiang G, Cohn L, Lee PJ. J Clin Invest. 2006 Nov; 2006 Oct 19. PMID: 17053835.", + "Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation. Homer RJ, Zhu Z, Cohn L, Lee CG, White WI, Chen S, Elias JA. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 2006 Mar 23. PMID: 16556727.", + "Mucus in chronic airway diseases: sorting out the sticky details. Cohn L. J Clin Invest. 2006 Feb. PMID: 16453018.", + "Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM, Elias JA. Nat Med. 2004 Oct; 2004 Sep 19. PMID: 15378055.", + "Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Zhu Z, Zheng T, Homer RJ, Kim YK, Chen NY, Cohn L, Hamid Q, Elias JA. Science. 2004 Jun 11. PMID: 15192232.", + "Asthma: mechanisms of disease persistence and progression. Cohn L, Elias JA, Chupp GL. Annu Rev Immunol. 2004. PMID: 15032597.", + "Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9. Whittaker L, Niu N, Temann UA, Stoddard A, Flavell RA, Ray A, Homer RJ, Cohn L. Am J Respir Cell Mol Biol. 2002 Nov. PMID: 12397019.", + "Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways. Lee CG, Homer RJ, Cohn L, Link H, Jung S, Craft JE, Graham BS, Johnson TR, Elias JA. J Biol Chem. 2002 Sep 20; 2002 Jul 9. PMID: 12107190.", + "Resolution of lung inflammation by CD44. Teder P, Vandivier RW, Jiang D, Liang J, Cohn L, Puré E, Henson PM, Noble PW. Science. 2002 Apr 5. PMID: 11935029.", + "Cytokine regulation of mucus production in a model of allergic asthma. Cohn L, Whittaker L, Niu N, Homer RJ. Novartis Found Symp. 2002. PMID: 12568496.", + "Food for thought: can immunological tolerance be induced to treat asthma? Cohn L. Am J Respir Cell Mol Biol. 2001 May. PMID: 11350818.", + "IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation. Cohn L, Herrick C, Niu N, Homer R, Bottomly K. J Immunol. 2001 Feb 15. PMID: 11160342.", + "A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Das J, Chen CH, Yang L, Cohn L, Ray P, Ray A. Nat Immunol. 2001 Jan. PMID: 11135577.", + "Altering the Th1/Th2 balance as a therapeutic strategy in asthmatic diseases. Ray A, Cohn L. Curr Opin Investig Drugs. 2000 Dec. PMID: 11249697.", + "T-helper type 2 cell-directed therapy for asthma. Cohn L, Ray A. Pharmacol Ther. 2000 Nov. PMID: 11150597.", + "IL-11 selectively inhibits aeroallergen-induced pulmonary eosinophilia and Th2 cytokine production. Wang J, Homer RJ, Hong L, Cohn L, Lee CG, Jung S, Elias JA. J Immunol. 2000 Aug 15. PMID: 10925310.", + "T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production. Cohn L, Homer RJ, Niu N, Bottomly K. J Exp Med. 1999 Nov 1. PMID: 10544202.", + "Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Zhang DH, Yang L, Cohn L, Parkyn L, Homer R, Ray P, Ray A. Immunity. 1999 Oct. PMID: 10549629.", + "Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation. Ray A, Cohn L. J Clin Invest. 1999 Oct. PMID: 10525032.", + "Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. Cohn L, Homer RJ, MacLeod H, Mohrs M, Brombacher F, Bottomly K. J Immunol. 1999 May 15. PMID: 10229862.", + "Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation. Yang L, Cohn L, Zhang DH, Homer R, Ray A, Ray P. J Exp Med. 1998 Nov 2. PMID: 9802985.", + "IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells. Cohn L, Tepper JS, Bottomly K. J Immunol. 1998 Oct 15. PMID: 9780144.", + "Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. Cohn L, Homer RJ, Marinov A, Rankin J, Bottomly K. J Exp Med. 1997 Nov 17. PMID: 9362533.", + "Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. Zhang DH, Cohn L, Ray P, Bottomly K, Ray A. J Biol Chem. 1997 Aug 22. PMID: 9261181.", + "", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Colón-Ramos Lab", + "lab_url": "https://medicine.yale.edu/lab/colon-ramos/", + "research_bio": "INFORMATION FOR Copy Link A fundamental question in neuroscience is how synapses are assembled in living animals to produce behaviors and store memories. Our lab is focused on this question and uses the nematodeC. elegansto examine the cell biological mechanisms by which synapses are precisely assembled during development, maintained during growth and modified during learning to store memories. A fundamental question in neuroscience is how synapses are assembled in living animals to produce behaviors and store memories. Our lab is focused on this question and uses the nematodeC. elegansto examine the cell biological mechanisms by which synapses are precisely assembled during development, maintained during growth and modified during learning to store memories. Cell biology of the synapse and behavior in C. eleganshttps://www.ibiology.org/neuroscience/neuronal-synapse/ Copy Link We can scrutinize the interplay between the cell biology of the synapse and behavior at three levels: Mechanisms of neuronal synapse assembly and functionhttps://www.ibiology.org/neuroscience/neuronal-synapse/#part-2 Actuating memory: how C. elegans remembershttps://www.ibiology.org/neuroscience/neuronal-synapse/#part-3 Copy Link", + "publications_page": "https://medicine.yale.edu/lab/colon-ramos/publications/", + "publications": null + }, + { + "lab_name": "Corlett Lab", + "lab_url": "https://medicine.yale.edu/lab/corlett/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/corlett/publications/", + "publications": null + }, + { + "lab_name": "Cosgrove Lab", + "lab_url": "https://medicine.yale.edu/lab/cosgrove/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Crair Laboratory", + "lab_url": "https://medicine.yale.edu/lab/crair/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Cytogenetics Lab", + "lab_url": "https://medicine.yale.edu/lab/cytogenetics/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Damisah Lab", + "lab_url": "https://medicine.yale.edu/lab/damisah/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Damsky Lab", + "lab_url": "https://medicine.yale.edu/lab/damsky/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Data Mining Lab", + "lab_url": "https://medicine.yale.edu/lab/fodeh/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/fodeh/publications", + "publications": null + }, + { + "lab_name": "Dawn Foster Lab", + "lab_url": "https://medicine.yale.edu/lab/dawnfoster/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "de Havenon Lab", + "lab_url": "https://medicine.yale.edu/lab/de-havenon/", + "research_bio": "INFORMATION FOR Despite being largely preventable, stroke remains one of the leading causes of death and disability worldwide. The de Havenon Lab is dedicated to addressing this global health challenge by identifying novel strategies for reducing stroke risk, preventing recurrent strokes, and improving post-stroke recovery outcomes. Our mission is to advance cerebrovascular research that bridges gaps and disparities in stroke prevention and care and to train the next generation of cerebrovascular researchers. Under the leadership of Adam de Havenon, MD, MSCI, a vascular neurologist with expertise in acute stroke treatment and outpatient care, the lab conducts clinical and epidemiological studies to advance research on vascular health. de Havenon’s research interests span intracranial atherosclerosis, blood pressure variability, vascular cognitive impairment, white matter hyperintensity, and the development of advanced neuroimaging techniques. Copy Link Associate Professor Term Clinical Research Project Manager Clinical Research Coordinator Hospital Resident Hospital Resident Gibbs Assistant Professor Assistant Professor of Neurology Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Dela Cruz Lab", + "lab_url": "https://medicine.yale.edu/lab/delacruz/", + "research_bio": "INFORMATION FOR Dr. Dela Cruz completed his research training through an MD/PhD program in the area of immunology and virology from University of Toronto and Yale. Clinically, he is trained in internal medicine, and specializes in pulmonary and critical care medicine and is currently an Assistant Professor at Yale University in the same department. His laboratory is interested in studying the pathogenesis of inflammation, injury and repair in the lung using genetically modified animals. This has allowed the lab to carefully study the molecular and cellular responses of certain novel mediators in the lung. His laboratory focuses on two main research programs. (1) Studying the effects of cigarette smoke (CS) exposure in the pathogenesis of airway and lung diseases such as chronic obstructive pulmonary disease (COPD) using preclinical genetic mouse models and human biosamples. (2) Studying novel immune regulators in the lung during respiratory infections. The goal of the lab is also to be able to confirm and translate the findings using biospecimens from the established and establishing cohort of human patients with various lung diseases Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/delacruz/publications", + "publications": null + }, + { + "lab_name": "Deniz Lab", + "lab_url": "https://medicine.yale.edu/lab/deniz/", + "research_bio": "INFORMATION FOR Many infants are born with excessive fluid in their brains, known as hydrocephalus, affecting 1/1000 live births. Our understanding of hydrocephalus is incomplete, which makes designing effective treatments much more difficult. Human genomic studies identified mutated genes in patients with congenital hydrocephalus, yet we do not know how they cause hydrocephalus. In Deniz Lab, we developed frogs as a rapid and effective model to study human congenital hydrocephalus genes. We use optical coherence tomography imaging to analyze CNS development, CNS ciliary function, and cerebrospinal fluid circulation dynamics in frogs. We can visualize CSF flow in real-time, vastly improving our candidate gene analysis derived from our patients. This model can lead to new insights into how hydrocephalus forms, providing an exciting avenue for understanding the disease process and designing new treatment options. Copy Link Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Deuterium Metabolic Imaging", + "lab_url": "https://medicine.yale.edu/lab/dmi/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Deziel Exposure Science Lab", + "lab_url": "https://medicine.yale.edu/lab/deziel/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "DIGITAL Insights Lab", + "lab_url": "https://medicine.yale.edu/lab/digital/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "DiLeone Lab", + "lab_url": "https://medicine.yale.edu/lab/dileone/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/dileone/publications/", + "publications": [ + "Yale School of Medicine /", + "Psychiatry /", + "Research", + "People", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "", + "", + "", + "", + "", + "", + "In Vivo PET Imaging of Preynaptic Density Reveals Stress-Associated Synaptic Deficits Related to Behavioral and Molecular Alterations in Rats. Asch RH, Hernandez Martin N, Garcia-Milian R, Fowles K, DiLeone RJ, Cai Z, Liston CM, Esterlis I. Biol Psychiatry Cogn Neurosci Neuroimaging. 2025 Sep 30; 2025 Sep 30. PMID: 41038318.", + "The NMDAR positive allosteric modulator NYX-783 selectively blocks opioid withdrawal conditioned place aversion in mice. Trinko JR, Foscue E, Diaz DM, Thompson SL, Malison RT, Sinha R, Taylor JR, DiLeone RJ. bioRxiv. 2025 Sep 25; 2025 Sep 25. PMID: 41040268.", + "Disruptions in Reward-Guided Decision-Making Functions Are Predictive of Greater Oral Oxycodone Self-Administration in Male and Female Rats. LaRocco K, Villiamma P, Hill J, Russell MA, DiLeone RJ, Groman SM. Biol Psychiatry Glob Open Sci. 2025 May; 2025 Jan 21. PMID: 40083740.", + "Vitamin D's Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [(11)C]-PHNO Positron Emission Tomography Study. Worhunsky PD, Mignosa MM, Gallezot JD, Pittman B, Nabulsi NB, Stryjewski A, Jalilian-Khave L, Trinko R, DiLeone RJ, Carson RE, Malison RT, Potenza MN, Angarita GA. Biol Psychiatry. 2025 Mar 15; 2024 Oct 10. PMID: 39395473.", + "Xylazine induces dopamine release and augments the effects of fentanyl. Trinko JR, Foscue E, Kong EM, Basu A, Corstens AM, Thompson SL, Kaye AP, Taylor JR, DiLeone RJ. J Clin Invest. 2024 Nov 15; 2024 Nov 15. PMID: 39545408.", + "Sex differences in oxycodone-taking behaviors are linked to disruptions in reward-guided, decision-making functions. LaRocco K, Villiamma P, Hill J, Russell MA, DiLeone RJ, Groman SM. bioRxiv. 2024 Apr 11; 2024 Apr 11. PMID: 38645212.", + "The endogenous opioid system in the medial prefrontal cortex mediates ketamine's antidepressant-like actions. Jiang C, DiLeone RJ, Pittenger C, Duman RS. Transl Psychiatry. 2024 Feb 12; 2024 Feb 12. PMID: 38346984.", + "The endogenous opioid system in the medial prefrontal cortex mediates ketamine's antidepressant-like actions. Pittenger C, Jiang C, DiLeone R, Duman R. Res Sq. 2023 Oct 3; 2023 Oct 3. PMID: 37886526.", + "Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study. van Galen KA, Schrantee A, Ter Horst KW, la Fleur SE, Booij J, Constable RT, Schwartz GJ, DiLeone RJ, Serlie MJ. Nat Metab. 2023 Jun; 2023 Jun 12. PMID: 37308722.", + "Ketogenic diet enhances the effects of oxycodone in mice. Trinko R, Diaz DM, Foscue E, Thompson SL, Taylor JR, DiLeone RJ. Sci Rep. 2023 May 9; 2023 May 9. PMID: 37160959.", + "Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [(18)F]FPEB and positron emission tomography study in rats. Asch RH, Pothula S, Toyonaga T, Fowles K, Groman SM, Garcia-Milian R, DiLeone RJ, Taylor JR, Esterlis I. Neuropsychopharmacology. 2023 Feb; 2022 Sep 13. PMID: 36100654.", + "Positive modulation of N-methyl-D-aspartate receptors in the mPFC reduces the spontaneous recovery of fear. Lee B, Pothula S, Wu M, Kang H, Girgenti MJ, Picciotto MR, DiLeone RJ, Taylor JR, Duman RS. Mol Psychiatry. 2022 May; 2022 Apr 14. PMID: 35418600.", + "Orexin 1 Receptor Antagonism in the Basolateral Amygdala Shifts the Balance From Pro- to Antistress Signaling and Behavior. Yaeger JDW, Krupp KT, Jacobs BM, Onserio BO, Meyerink BL, Cain JT, Ronan PJ, Renner KJ, DiLeone RJ, Summers CH. Biol Psychiatry. 2022 May 1; 2022 Jan 19. PMID: 35279280.", + "Cerebellar neurons that curb food consumption. Simerly R, DiLeone R. Nature. 2021 Dec. PMID: 34789886.", + "The response to prolonged fasting in hypothalamic serotonin transporter availability is blunted in obesity. van Galen KA, Booij J, Schrantee A, Adriaanse SM, Unmehopa UA, Fliers E, Schwartz GJ, DiLeone RJ, Ter Horst KW, la Fleur SE, Serlie MJ. Metabolism. 2021 Oct; 2021 Jul 29. PMID: 34331964.", + "Bringing in the ACE(i): Angiotensin-Converting Enzyme Inhibitors as Antidepressants. Hare BD, DiLeone RJ. Biol Psychiatry. 2020 Sep 1. PMID: 32792051.", + "Medial Nucleus Accumbens Projections to the Ventral Tegmental Area Control Food Consumption. Bond CW, Trinko R, Foscue E, Furman K, Groman SM, Taylor JR, DiLeone RJ. J Neurosci. 2020 Jun 10; 2020 Apr 30. PMID: 32354856.", + "Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice. Flanigan ME, Aleyasin H, Li L, Burnett CJ, Chan KL, LeClair KB, Lucas EK, Matikainen-Ankney B, Durand-de Cuttoli R, Takahashi A, Menard C, Pfau ML, Golden SA, Bouchard S, Calipari ES, Nestler EJ, DiLeone RJ, Yamanaka A, Huntley GW, Clem RL, Russo SJ. Nat Neurosci. 2020 May; 2020 Apr 13. PMID: 32284606.", + "Ketamine increases vmPFC activity: Effects of (R)- and (S)-stereoisomers and (2R,6R)-hydroxynorketamine metabolite. Hare BD, Pothula S, DiLeone RJ, Duman RS. Neuropharmacology. 2020 Apr; 2020 Jan 9. PMID: 31926944.", + "Orbitofrontal Circuits Control Multiple Reinforcement-Learning Processes. Groman SM, Keistler C, Keip AJ, Hammarlund E, DiLeone RJ, Pittenger C, Lee D, Taylor JR. Neuron. 2019 Aug 21; 2019 Jun 25. PMID: 31253468.", + "Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects. Hare BD, Shinohara R, Liu RJ, Pothula S, DiLeone RJ, Duman RS. Nat Commun. 2019 Jan 15; 2019 Jan 15. PMID: 30644390.", + "Striatal dopamine regulates systemic glucose metabolism in humans and mice. Ter Horst KW, Lammers NM, Trinko R, Opland DM, Figee M, Ackermans MT, Booij J, van den Munckhof P, Schuurman PR, Fliers E, Denys D, DiLeone RJ, la Fleur SE, Serlie MJ. Sci Transl Med. 2018 May 23. PMID: 29794060.", + "Down-regulation of miRNAs in the brain and development of diet-induced obesity. Maldonado-Avilés JG, Guarnieri DJ, Zhu X, DiLeone RJ. Int J Dev Neurosci. 2018 Feb; 2017 Jun 23. PMID: 28652200.", + "Regulation of Alcohol Extinction and Cue-Induced Reinstatement by Specific Projections among Medial Prefrontal Cortex, Nucleus Accumbens, and Basolateral Amygdala. Keistler CR, Hammarlund E, Barker JM, Bond CW, DiLeone RJ, Pittenger C, Taylor JR. J Neurosci. 2017 Apr 26; 2017 Mar 23. PMID: 28336571.", + "Lip Sync: Gamma Rhythms Orchestrate Top-Down Control of Feeding Circuits. Narayanan NS, DiLeone RJ. Cell Metab. 2017 Mar 7. PMID: 28273473.", + "Characterization of GABAergic marker expression in the chronic unpredictable stress model of depression. Banasr M, Lepack A, Fee C, Duric V, Maldonado-Aviles J, DiLeone R, Sibille E, Duman RS, Sanacora G. Chronic Stress (Thousand Oaks). 2017 Feb; 2017 Aug 3. PMID: 28835932.", + "The vitamin D metabolites 25(OH)D and 1,25(OH)(2)D are not related to either glucose metabolism or insulin action in obese women. Ter Horst KW, Versteeg RI, Gilijamse PW, Ackermans MT, Heijboer AC, Romijn JA, la Fleur SE, Trinko R, DiLeone RJ, Serlie MJ. Diabetes Metab. 2016 Dec; 2016 Jun 1. PMID: 27262368.", + "Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AFT, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA Jr, Carter CS, Cook EH Jr, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA Jr, Zubieta JK. Biol Psychiatry. 2016 Jul 15. PMID: 27346079.", + "Innate Fear-Induced Weight Regulation in the C57BL/6J Mouse. Genné-Bacon EA, Trinko JR, DiLeone RJ. Front Behav Neurosci. 2016; 2016 Jul 4. PMID: 27458352.", + "Vitamin D3: A Role in Dopamine Circuit Regulation, Diet-Induced Obesity, and Drug Consumption. Trinko JR, Land BB, Solecki WB, Wickham RJ, Tellez LA, Maldonado-Aviles J, de Araujo IE, Addy NA, DiLeone RJ. eNeuro. 2016 Mar-Apr; 2016 May 19. PMID: 27257625.", + "Activity of D1/2 Receptor Expressing Neurons in the Nucleus Accumbens Regulates Running, Locomotion, and Food Intake. Zhu X, Ottenheimer D, DiLeone RJ. Front Behav Neurosci. 2016; 2016 Apr 12. PMID: 27147989.", + "Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation. Hayes MR, Skibicka KP, Leichner TM, Guarnieri DJ, DiLeone RJ, Bence KK, Grill HJ. Cell Metab. 2016 Apr 12. PMID: 27076082.", + "Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit. D'Agostino G, Lyons DJ, Cristiano C, Burke LK, Madara JC, Campbell JN, Garcia AP, Land BB, Lowell BB, Dileone RJ, Heisler LK. Elife. 2016 Mar 14; 2016 Mar 14. PMID: 26974347.", + "Serotonin (5-HT) 5-HT2A Receptor (5-HT2AR):5-HT2CR Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity. Anastasio NC, Stutz SJ, Fink LH, Swinford-Jackson SE, Sears RM, DiLeone RJ, Rice KC, Moeller FG, Cunningham KA. ACS Chem Neurosci. 2015 Jul 15; 2015 Jul 7. PMID: 26120876.", + "Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions. Fuchikami M, Thomas A, Liu R, Wohleb ES, Land BB, DiLeone RJ, Aghajanian GK, Duman RS. Proc Natl Acad Sci U S A. 2015 Jun 30; 2015 Jun 8. PMID: 26056286.", + "Ribosomal protein S6 kinase 1 signaling in prefrontal cortex controls depressive behavior. Dwyer JM, Maldonado-Avilés JG, Lepack AE, DiLeone RJ, Duman RS. Proc Natl Acad Sci U S A. 2015 May 12; 2015 Apr 27. PMID: 25918363.", + "Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity. van den Heuvel JK, Furman K, Gumbs MC, Eggels L, Opland DM, Land BB, Kolk SM, Narayanan NS, Fliers E, Kalsbeek A, DiLeone RJ, la Fleur SE. Biol Psychiatry. 2015 Apr 1; 2014 Jun 18. PMID: 25109664.", + "Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome. Xu M, Kobets A, Du JC, Lennington J, Li L, Banasr M, Duman RS, Vaccarino FM, DiLeone RJ, Pittenger C. Proc Natl Acad Sci U S A. 2015 Jan 20; 2015 Jan 5. PMID: 25561540.", + "Leptin mediates the increase in blood pressure associated with obesity. Simonds SE, Pryor JT, Ravussin E, Greenway FL, Dileone R, Allen AM, Bassi J, Elmquist JK, Keogh JM, Henning E, Myers MG Jr, Licinio J, Brown RD, Enriori PJ, O'Rahilly S, Sternson SM, Grove KL, Spanswick DC, Farooqi IS, Cowley MA. Cell. 2014 Dec 4. PMID: 25480301.", + "Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Cansell C, Castel J, Denis RG, Rouch C, Delbes AS, Martinez S, Mestivier D, Finan B, Maldonado-Aviles JG, Rijnsburger M, Tschöp MH, DiLeone RJ, Eckel RH, la Fleur SE, Magnan C, Hnasko TS, Luquet S. Mol Psychiatry. 2014 Oct; 2014 Apr 15. PMID: 24732670.", + "GABAergic and glutamatergic efferents of the mouse ventral tegmental area. Taylor SR, Badurek S, Dileone RJ, Nashmi R, Minichiello L, Picciotto MR. J Comp Neurol. 2014 Oct 1. PMID: 24715505.", + "Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice. Kim JD, Toda C, D'Agostino G, Zeiss CJ, DiLeone RJ, Elsworth JD, Kibbey RG, Chan O, Harvey BK, Richie CT, Savolainen M, Myöhänen T, Jeong JK, Diano S. Proc Natl Acad Sci U S A. 2014 Aug 12; 2014 Jul 28. PMID: 25071172.", + "Heightened vagal activity during high-calorie food presentation in obese compared with non-obese individuals--results of a pilot study. Udo T, Weinberger AH, Grilo CM, Brownell KD, DiLeone RJ, Lampert R, Matlin SL, Yanagisawa K, McKee SA. Obes Res Clin Pract. 2014 May-Jun. PMID: 24847667.", + "REDD1 is essential for stress-induced synaptic loss and depressive behavior. Ota KT, Liu RJ, Voleti B, Maldonado-Aviles JG, Duric V, Iwata M, Dutheil S, Duman C, Boikess S, Lewis DA, Stockmeier CA, DiLeone RJ, Rex C, Aghajanian GK, Duman RS. Nat Med. 2014 May; 2014 Apr 13. PMID: 24728411.", + "Optogenetic inhibition of neurons by internal light production. Land BB, Brayton CE, Furman KE, Lapalombara Z, Dileone RJ. Front Behav Neurosci. 2014; 2014 Apr 1. PMID: 24744708.", + "Inhaling: endocannabinoids and food intake. Maldonado-Avilés JG, Dileone RJ. Nat Neurosci. 2014 Mar. PMID: 24569827.", + "Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdala. Arendt DH, Hassell J, Li H, Achua JK, Guarnieri DJ, Dileone RJ, Ronan PJ, Summers CH. Psychoneuroendocrinology. 2014 Feb; 2013 Oct 30. PMID: 24485472.", + "Medial prefrontal D1 dopamine neurons control food intake. Land BB, Narayanan NS, Liu RJ, Gianessi CA, Brayton CE, Grimaldi DM, Sarhan M, Guarnieri DJ, Deisseroth K, Aghajanian GK, DiLeone RJ. Nat Neurosci. 2014 Feb; 2014 Jan 19. PMID: 24441680.", + "Functional status of the serotonin 5-HT2C receptor (5-HT2CR) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence. Anastasio NC, Stutz SJ, Fox RG, Sears RM, Emeson RB, DiLeone RJ, O'Neil RT, Fink LH, Li D, Green TA, Moeller FG, Cunningham KA. Neuropsychopharmacology. 2014 Jan; 2013 Aug 13. PMID: 23939424.", + "The orbitofrontal cortex regulates outcome-based decision-making via the lateral striatum. Gourley SL, Olevska A, Zimmermann KS, Ressler KJ, Dileone RJ, Taylor JR. Eur J Neurosci. 2013 Aug; 2013 May 8. PMID: 23651226.", + "BDNF parabrachio-amygdaloid pathway in morphine-induced analgesia. Sarhan M, Pawlowski SA, Barthas F, Yalcin I, Kaufling J, Dardente H, Zachariou V, Dileone RJ, Barrot M, Veinante P. Int J Neuropsychopharmacol. 2013 Aug; 2013 Feb 21. PMID: 23425507.", + "Flavor-independent maintenance, extinction, and reinstatement of fat self-administration in mice. Tellez LA, Ferreira JG, Medina S, Land BB, DiLeone RJ, de Araujo IE. Biol Psychiatry. 2013 May 1. PMID: 23587200.", + "Modeling the effects of positive and negative mood on the ability to resist eating in obese and non-obese individuals. Udo T, Grilo CM, Brownell KD, Weinberger AH, Dileone RJ, McKee SA. Eat Behav. 2013 Jan; 2012 Oct 31. PMID: 23265400.", + "Transcriptional plasticity in the brain following metabolic challenge. Guarnieri DJ, DiLeone RJ. Neuropsychopharmacology. 2013 Jan. PMID: 23147479.", + "Prefrontal D1 dopamine signaling is required for temporal control. Narayanan NS, Land BB, Solder JE, Deisseroth K, DiLeone RJ. Proc Natl Acad Sci U S A. 2012 Dec 11; 2012 Nov 26. PMID: 23185016.", + "Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding. Gourley SL, Swanson AM, Jacobs AM, Howell JL, Mo M, Dileone RJ, Koleske AJ, Taylor JR. Proc Natl Acad Sci U S A. 2012 Dec 11; 2012 Nov 26. PMID: 23185000.", + "The drive to eat: comparisons and distinctions between mechanisms of food reward and drug addiction. DiLeone RJ, Taylor JR, Picciotto MR. Nat Neurosci. 2012 Oct; 2012 Sep 25. PMID: 23007187.", + "Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals. Kanoski SE, Zhao S, Guarnieri DJ, DiLeone RJ, Yan J, De Jonghe BC, Bence KK, Hayes MR, Grill HJ. Am J Physiol Endocrinol Metab. 2012 Aug 15; 2012 Jun 12. PMID: 22693203.", + "Losing the lust for life: a new role for an old feeding Peptide? Land BB, DiLeone RJ. Neuron. 2012 Aug 9. PMID: 22884320.", + "Serum and plasma brain-derived neurotrophic factor (BDNF) in abstinent alcoholics and social drinkers. D'Sa C, Dileone RJ, Anderson GM, Sinha R. Alcohol. 2012 May; 2012 Feb 22. PMID: 22364688.", + "Gene profiling reveals a role for stress hormones in the molecular and behavioral response to food restriction. Guarnieri DJ, Brayton CE, Richards SM, Maldonado-Aviles J, Trinko JR, Nelson J, Taylor JR, Gourley SL, DiLeone RJ. Biol Psychiatry. 2012 Feb 15. PMID: 21855858.", + "Increased serum brain-derived neurotrophic factor is predictive of cocaine relapse outcomes: a prospective study. D'Sa C, Fox HC, Hong AK, Dileone RJ, Sinha R. Biol Psychiatry. 2011 Oct 15; 2011 Jul 8. PMID: 21741029.", + "Can food be addictive? Public health and policy implications. Gearhardt AN, Grilo CM, DiLeone RJ, Brownell KD, Potenza MN. Addiction. 2011 Jul; 2011 Feb 14. PMID: 21635588.", + "Nicotine decreases food intake through activation of POMC neurons. Mineur YS, Abizaid A, Rao Y, Salas R, DiLeone RJ, Gündisch D, Diano S, De Biasi M, Horvath TL, Gao XB, Picciotto MR. Science. 2011 Jun 10. PMID: 21659607.", + "Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat. Mul JD, la Fleur SE, Toonen PW, Afrasiab-Middelman A, Binnekade R, Schetters D, Verheij MM, Sears RM, Homberg JR, Schoffelmeer AN, Adan RA, DiLeone RJ, De Vries TJ, Cuppen E. PLoS One. 2011 May 5; 2011 May 5. PMID: 21573180.", + "Neuroscience gets nutrition. DiLeone RJ. Nat Neurosci. 2011 Mar. PMID: 21346742.", + "Erk1/2 mediates leptin receptor signaling in the ventral tegmental area. Trinko R, Gan G, Gao XB, Sears RM, Guarnieri DJ, DiLeone RJ. PLoS One. 2011; 2011 Nov 4. PMID: 22076135.", + "The neuronal PAS domain protein 4 (Npas4) is required for new and reactivated fear memories. Ploski JE, Monsey MS, Nguyen T, DiLeone RJ, Schafe GE. PLoS One. 2011; 2011 Aug 22. PMID: 21887312.", + "Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior. Mukherjee S, Coque L, Cao JL, Kumar J, Chakravarty S, Asaithamby A, Graham A, Gordon E, Enwright JF 3rd, DiLeone RJ, Birnbaum SG, Cooper DC, McClung CA. Biol Psychiatry. 2010 Sep 15; 2010 Jun 29. PMID: 20591414.", + "Wnt2 expression and signaling is increased by different classes of antidepressant treatments. Okamoto H, Voleti B, Banasr M, Sarhan M, Duric V, Girgenti MJ, Dileone RJ, Newton SS, Duman RS. Biol Psychiatry. 2010 Sep 15; 2010 Jun 8. PMID: 20570247.", + "Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone. Sears RM, Liu RJ, Narayanan NS, Sharf R, Yeckel MF, Laubach M, Aghajanian GK, DiLeone RJ. J Neurosci. 2010 Jun 16. PMID: 20554878.", + "Orexin signaling via the orexin 1 receptor mediates operant responding for food reinforcement. Sharf R, Sarhan M, Brayton CE, Guarnieri DJ, Taylor JR, DiLeone RJ. Biol Psychiatry. 2010 Apr 15; 2010 Feb 26. PMID: 20189166.", + "Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization. Sharf R, Guarnieri DJ, Taylor JR, DiLeone RJ. Brain Res. 2010 Mar 4; 2009 Dec 23. PMID: 20034477.", + "Role of orexin/hypocretin in dependence and addiction. Sharf R, Sarhan M, Dileone RJ. Brain Res. 2010 Feb 16; 2009 Aug 20. PMID: 19699189.", + "Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation. Hayes MR, Skibicka KP, Leichner TM, Guarnieri DJ, DiLeone RJ, Bence KK, Grill HJ. Cell Metab. 2010 Jan. PMID: 20074530.", + "Metabolic hormones, dopamine circuits, and feeding. Narayanan NS, Guarnieri DJ, DiLeone RJ. Front Neuroendocrinol. 2010 Jan; 2009 Oct 28. PMID: 19836414.", + "Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction. Gourley SL, Howell JL, Rios M, DiLeone RJ, Taylor JR. Learn Mem. 2009 Dec; 2009 Nov 19. PMID: 19926781.", + "Striatal overexpression of DeltaJunD resets L-DOPA-induced dyskinesia in a primate model of Parkinson disease. Berton O, Guigoni C, Li Q, Bioulac BH, Aubert I, Gross CE, Dileone RJ, Nestler EJ, Bezard E. Biol Psychiatry. 2009 Sep 15; 2009 May 28. PMID: 19481198.", + "DeltaFosB induction in orbitofrontal cortex potentiates locomotor sensitization despite attenuating the cognitive dysfunction caused by cocaine. Winstanley CA, Green TA, Theobald DE, Renthal W, LaPlant Q, DiLeone RJ, Chakravarty S, Nestler EJ. Pharmacol Biochem Behav. 2009 Sep; 2008 Dec 16. PMID: 19135469.", + "Leptin: taking the path less traveled. DiLeone RJ. Cell Metab. 2009 Aug. PMID: 19656482.", + "The influence of leptin on the dopamine system and implications for ingestive behavior. DiLeone RJ. Int J Obes (Lond). 2009 Jun. PMID: 19528975.", + "Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Graham DL, Krishnan V, Larson EB, Graham A, Edwards S, Bachtell RK, Simmons D, Gent LM, Berton O, Bolanos CA, DiLeone RJ, Parada LF, Nestler EJ, Self DW. Biol Psychiatry. 2009 Apr 15; 2008 Nov 6. PMID: 18990365.", + "Primate models of schizophrenia: future possibilities. Simen AA, DiLeone R, Arnsten AF. Prog Brain Res. 2009; 2009 Nov 20. PMID: 20302824.", + "The influence of DeltaFosB in the nucleus accumbens on natural reward-related behavior. Wallace DL, Vialou V, Rios L, Carle-Florence TL, Chakravarty S, Kumar A, Graham DL, Green TA, Kirk A, Iñiguez SD, Perrotti LI, Barrot M, DiLeone RJ, Nestler EJ, Bolaños-Guzmán CA. J Neurosci. 2008 Oct 8. PMID: 18842886.", + "Orexin mediates the expression of precipitated morphine withdrawal and concurrent activation of the nucleus accumbens shell. Sharf R, Sarhan M, Dileone RJ. Biol Psychiatry. 2008 Aug 1; 2008 Apr 18. PMID: 18423425.", + "MicroRNAs: a new class of gene regulators. Guarnieri DJ, DiLeone RJ. Ann Med. 2008. PMID: 18382885.", + "Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability. Benavides DR, Quinn JJ, Zhong P, Hawasli AH, DiLeone RJ, Kansy JW, Olausson P, Yan Z, Taylor JR, Bibb JA. J Neurosci. 2007 Nov 21. PMID: 18032670.", + "Dynamic contribution of nestin-expressing stem cells to adult neurogenesis. Lagace DC, Whitman MC, Noonan MA, Ables JL, DeCarolis NA, Arguello AA, Donovan MH, Fischer SJ, Farnbauch LA, Beech RD, DiLeone RJ, Greer CA, Mandyam CD, Eisch AJ. J Neurosci. 2007 Nov 14. PMID: 18003841.", + "DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction. Winstanley CA, LaPlant Q, Theobald DE, Green TA, Bachtell RK, Perrotti LI, DiLeone RJ, Russo SJ, Garth WJ, Self DW, Nestler EJ. J Neurosci. 2007 Sep 26. PMID: 17898221.", + "Neural mechanisms underlying obesity and drug addiction. Trinko R, Sears RM, Guarnieri DJ, DiLeone RJ. Physiol Behav. 2007 Aug 15; 2007 Jan 16. PMID: 17292426.", + "Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Graham DL, Edwards S, Bachtell RK, DiLeone RJ, Rios M, Self DW. Nat Neurosci. 2007 Aug; 2007 Jul 8. PMID: 17618281.", + "Addiction and arousal: alternative roles of hypothalamic peptides. de Lecea L, Jones BE, Boutrel B, Borgland SL, Nishino S, Bubser M, DiLeone R. J Neurosci. 2006 Oct 11. PMID: 17035520.", + "Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Hommel JD, Trinko R, Sears RM, Georgescu D, Liu ZW, Gao XB, Thurmon JJ, Marinelli M, DiLeone RJ. Neuron. 2006 Sep 21. PMID: 16982424.", + "Induction of inducible cAMP early repressor expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli. Green TA, Alibhai IN, Hommel JD, DiLeone RJ, Kumar A, Theobald DE, Neve RL, Nestler EJ. J Neurosci. 2006 Aug 9. PMID: 16899718.", + "Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW, Nestler EJ. Science. 2006 Feb 10. PMID: 16469931.", + "An essential role for DeltaFosB in the nucleus accumbens in morphine action. Zachariou V, Bolanos CA, Selley DE, Theobald D, Cassidy MP, Kelz MB, Shaw-Lutchman T, Berton O, Sim-Selley LJ, Dileone RJ, Kumar A, Nestler EJ. Nat Neurosci. 2006 Feb; 2006 Jan 15. PMID: 16415864.", + "The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. Georgescu D, Sears RM, Hommel JD, Barrot M, Bolaños CA, Marsh DJ, Bednarek MA, Bibb JA, Maratos-Flier E, Nestler EJ, DiLeone RJ. J Neurosci. 2005 Mar 16. PMID: 15772353.", + "Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice. Holder JL Jr, Zhang L, Kublaoui BM, DiLeone RJ, Oz OK, Bair CH, Lee YH, Zinn AR. Am J Physiol Endocrinol Metab. 2004 Jul; 2004 Feb 24. PMID: 14982752.", + "Local gene knockdown in the brain using viral-mediated RNA interference. Hommel JD, Sears RM, Georgescu D, Simmons DL, DiLeone RJ. Nat Med. 2003 Dec; 2003 Nov 23. PMID: 14634645.", + "Essential role for RGS9 in opiate action. Zachariou V, Georgescu D, Sanchez N, Rahman Z, DiLeone R, Berton O, Neve RL, Sim-Selley LJ, Selley DE, Gold SJ, Nestler EJ. Proc Natl Acad Sci U S A. 2003 Nov 11; 2003 Oct 31. PMID: 14595021.", + "Connecticut Mental Health Center 34 Park Street New Haven, CT 06510", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "DiMaio Lab", + "lab_url": "https://medicine.yale.edu/lab/dimaio/", + "research_bio": "INFORMATION FOR We study tumor viruses to learn how they interact with cells and control proliferation and other aspects of cell behavior. Our research focuses on the papillomaviruses and polyomaviruses, small DNA viruses that transform cells in culture and play an important role in several forms of human cancer and other diseases. Our current studies aim to determine at the molecular level how viral oncogenes transform cells and cause cancer and how these viruses use cellular machinery to enter cells. We have discovered a unique mechanism of cell transformation and identified novel cellular proteins required for tumor virus entry. Based on our understanding of viral oncoproteins, we are developing novel approaches to build artificial transmembrane proteins that can activate or inhibit growth factor receptors, stimulate red blood cell formation, or block HIV infection. In the course of these studies, we have isolated small proteins with unprecedented chemical simplicity, which display no sequence homology to any naturally occurring proteins. Our studies are providing new insights into the mechanisms of cell growth control and protein action and are suggesting new strategies to treat or prevent human cancer. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/dimaio/publications", + "publications": null + }, + { + "lab_name": "Dixit Lab", + "lab_url": "https://medicine.yale.edu/lab/dixit/", + "research_bio": "INFORMATION FOR The Dixit Lab is focused on understanding the interactions between metabolic and immune systems with the goal of revealing molecular targets that can be harnessed to control inflammation and immune dysfunction as means to enhance the health span. Copy Link Yale Pathology 310 Cedar Street PO Box 208023 New Haven, CT 06520-8023 Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Dragoi Lab", + "lab_url": "https://medicine.yale.edu/lab/dragoi/", + "research_bio": "INFORMATION FOR Our cognitive life depends on our ability to generate internal representations of the external world. Internal representations can be driven by the external stimuli (e.g., perceptions) or can be internally-generated in their absence (e.g., imagining, memory). The dynamic interplay between externally-driven and internally-generated representations is thought to be disrupted in neuropsychiatric conditions such as schizophrenia, autism, and Alzheimer’s disease. The long-term goal of the lab is to map and dissect the neural circuits and decipher the neuronal codes underlying the formation of internal representations within hippocampal-neocortical networks that support innate and learned behavior, with implications for our understanding of neuropsychiatric diseases. Copy Link Department of Psychiatry300 George StreetSuite 9144 ANew Haven, CT 06511 T: 203.785.4515 george.dragoi@yale.edu Copy Link", + "publications_page": "https://medicine.yale.edu/lab/dragoi/publications/", + "publications": [ + "Yale School of Medicine /", + "Psychiatry /", + "Research", + "Photos", + "People", + "Join", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "News", + "Photos", + "Join", + "", + "", + "", + "", + "", + "", + "Generative emergence of non-local representations in the hippocampus. Zhou Y, Sibille J, Dragoi G. Nat Commun. 2025 Aug 27; 2025 Aug 27. PMID: 40866358.", + "Experience of Euclidean geometry sculpts the development and dynamics of rodent hippocampal sequential cell assemblies. Farooq U, Dragoi G. Nat Commun. 2024 Sep 28; 2024 Sep 28. PMID: 39341810.", + "Publisher Correction: Nested compressed co-representations of multiple sequential experiences during sleep. Liu K, Sibille J, Dragoi G. Nat Neurosci. 2024 Sep. PMID: 39147942.", + "Nested compressed co-representations of multiple sequential experiences during sleep. Liu K, Sibille J, Dragoi G. Nat Neurosci. 2024 Sep; 2024 Jul 19. PMID: 39030341.", + "The generative grammar of the brain: a critique of internally generated representations. Dragoi G. Nat Rev Neurosci. 2024 Jan; 2023 Nov 30. PMID: 38036709.", + "Geometric experience sculpts the development and dynamics of hippocampal sequential cell assemblies. Farooq U, Dragoi G. bioRxiv. 2023 Dec 6; 2023 Dec 6. PMID: 38105999.", + "Orientation selectivity enhances context generalization and generative predictive coding in the hippocampus. Liu K, Sibille J, Dragoi G. Neuron. 2021 Nov 17; 2021 Sep 9. PMID: 34506724.", + "The Ontogeny of Hippocampus-Dependent Memories. Donato F, Alberini CM, Amso D, Dragoi G, Dranovsky A, Newcombe NS. J Neurosci. 2021 Feb 3; 2020 Dec 16. PMID: 33328296.", + "Cell assemblies, sequences and temporal coding in the hippocampus. Dragoi G. Curr Opin Neurobiol. 2020 Oct; 2020 May 3. PMID: 32375084.", + "A consensus statement: defining terms for reactivation analysis. Genzel L, Dragoi G, Frank L, Ganguly K, de la Prida L, Pfeiffer B, Robertson E. Philos Trans R Soc Lond B Biol Sci. 2020 May 25; 2020 Apr 6. PMID: 32248790.", + "Strengthened Temporal Coordination within Pre-existing Sequential Cell Assemblies Supports Trajectory Replay. Farooq U, Sibille J, Liu K, Dragoi G. Neuron. 2019 Aug 21; 2019 Jun 25. PMID: 31253469.", + "Preconfigured patterns are the primary driver of offline multi-neuronal sequence replay. Liu K, Sibille J, Dragoi G. Hippocampus. 2019 Mar; 2018 Nov 22. PMID: 30260526.", + "Emergence of preconfigured and plastic time-compressed sequences in early postnatal development. Farooq U, Dragoi G. Science. 2019 Jan 11. PMID: 30630930.", + "Generative Predictive Codes by Multiplexed Hippocampal Neuronal Tuplets. Liu K, Sibille J, Dragoi G. Neuron. 2018 Sep 19; 2018 Aug 23. PMID: 30146305.", + "Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective. Krystal JH, Anticevic A, Yang GJ, Dragoi G, Driesen NR, Wang XJ, Murray JD. Biol Psychiatry. 2017 May 15; 2017 Jan 13. PMID: 28434616.", + "Selection of preconfigured cell assemblies for representation of novel spatial experiences. Dragoi G, Tonegawa S. Philos Trans R Soc Lond B Biol Sci. 2014 Feb 5; 2013 Dec 23. PMID: 24366134.", + "Development of schemas revealed by prior experience and NMDA receptor knock-out. Dragoi G, Tonegawa S. Elife. 2013 Dec 10; 2013 Dec 10. PMID: 24327561.", + "Internal operations in the hippocampus: single cell and ensemble temporal coding. Dragoi G. Front Syst Neurosci. 2013; 2013 Aug 29. PMID: 24009564.", + "Distinct preplay of multiple novel spatial experiences in the rat. Dragoi G, Tonegawa S. Proc Natl Acad Sci U S A. 2013 May 28; 2013 May 13. PMID: 23671088.", + "Preplay of future place cell sequences by hippocampal cellular assemblies. Dragoi G, Tonegawa S. Nature. 2011 Jan 20; 2010 Dec 22. PMID: 21179088.", + "Temporal encoding of place sequences by hippocampal cell assemblies. Dragoi G, Buzsáki G. Neuron. 2006 Apr 6. PMID: 16600862.", + "Place representation within hippocampal networks is modified by long-term potentiation. Dragoi G, Harris KD, Buzsáki G. Neuron. 2003 Aug 28. PMID: 12948450.", + "Organization of cell assemblies in the hippocampus. Harris KD, Csicsvari J, Hirase H, Dragoi G, Buzsáki G. Nature. 2003 Jul 31. PMID: 12891358.", + "Homeostatic maintenance of neuronal excitability by burst discharges in vivo. Buzsáki G, Csicsvari J, Dragoi G, Harris K, Henze D, Hirase H. Cereb Cortex. 2002 Sep. PMID: 12183388.", + "Spike train dynamics predicts theta-related phase precession in hippocampal pyramidal cells. Harris KD, Henze DA, Hirase H, Leinekugel X, Dragoi G, Czurkó A, Buzsáki G. Nature. 2002 Jun 13. PMID: 12066184.", + "Hippocampal pyramidal cell-interneuron spike transmission is frequency dependent and responsible for place modulation of interneuron discharge. Marshall L, Henze DA, Hirase H, Leinekugel X, Dragoi G, Buzsáki G. J Neurosci. 2002 Jan 15. PMID: 11784809.", + "Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat. Dragoi G, Carpi D, Recce M, Csicsvari J, Buzsáki G. J Neurosci. 1999 Jul 15. PMID: 10407055.", + "Department of Psychiatry 300 George Street New Haven, CT 06511", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Ehrlich Laboratory", + "lab_url": "https://medicine.yale.edu/lab/ehrlich/", + "research_bio": "INFORMATION FOR We are interested in how cells regulate the intracellular calcium concentration. Cells use changes in calcium as a trigger for many cellular events, including muscle contraction, hormone secretion, and cell growth. The change in calcium levels can be modulated by the cell to tailor its response to the prevailing conditions. We have focused on one aspect of this process, the release of calcium from intracellular stores. We use biophysical, molecular and biochemical techniques to study the classes of calcium release channels known to exist inside virtually all cells the InsP3-gated channel, the ryanodine receptor/channel, and polycystin-2. Our goal is to understand how the functions of these channels are altered by processes within the cell. The knowledge of how these channels work will form the background for studies of disease-induced changes in calcium release channel function. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/ehrlich/publications/", + "publications": [ + "Yale School of Medicine /", + "Pharmacology /", + "Projects Intracellular Channels InsP3 Receptor Ryanodine Receptor Polycystin-2 Regulation of calcium signals Regulation of calcium signals Parvalbumin", + "Intracellular Channels InsP3 Receptor Ryanodine Receptor Polycystin-2", + "InsP3 Receptor", + "Ryanodine Receptor", + "Polycystin-2", + "Regulation of calcium signals", + "Regulation of calcium signals Parvalbumin", + "Parvalbumin", + "Publications", + "Lab Members", + "Contact Us", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Projects", + "Publications", + "Lab Members", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Monomethyl auristatin E and paclitaxel use different mechanisms to alter intracellular calcium signaling. Mendes GMM, Munshani S, Wachtler N, Wopfner H, Gong X, Sun Z, Mak M, Ehrlich BE. Biochem Pharmacol. 2025 Dec; 2025 Jul 26. PMID: 40721011.", + "Pathological Calcium Signaling in Traumatic Brain Injury and Alzheimer's Disease: From Acute Neuronal Injury to Chronic Neurodegeneration. Neuschmid S, Schallerer C, Ehrlich BE, McGuone D. Int J Mol Sci. 2025 Sep 22; 2025 Sep 22. PMID: 41009808.", + "Chemotherapy-induced neuropathy in monomethyl Auristatin E treatment: prevention by lithium. Itaborahy MF, Feng IZLF, Vieira-Machado UF, da Silveira IB, Valverde TM, Costa GMJ, Guimarães JDS, Laet-Souza D, Malamut C, Martins MAF, Marques JM, Rezende-Ribeiro J, Gorshkov V, Kjeldsen F, Favalessa MES, Acipreste IF, Verano-Braga T, Carvalho HF, Oliveira AG, Dias ML, Goes AM, Ehrlich BE, Leite MF. Br J Cancer. 2025 Sep; 2025 Jul 1. PMID: 40595283.", + "Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer. Gong X, Ogino N, Leite MF, Zhang D, Chen Z, Nguyen RY, Liu R, Kruglov E, Flores K, Cabral AT, Moreira de M Mendes G, Ehrlich BE, Mak M. Cancer Res. 2025 Aug 15. PMID: 40387600.", + "Calpain in Traumatic Brain Injury: From Cinderella to Central Player. Schallerer C, Neuschmid S, Ehrlich BE, McGuone D. Cells. 2025 Aug 14; 2025 Aug 14. PMID: 40862734.", + "Exploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury. Wachtler N, O'Brien R, Ehrlich BE, McGuone D. Pharmaceuticals (Basel). 2025 Feb 6; 2025 Feb 6. PMID: 40006037.", + "Corrigendum to \"Modulating TRPV4 channels with paclitaxel and lithium\" [Cell Calcium 91 (2020) 102266]. Sánchez JC, Muñoz LV, Ehrlich BE. Cell Calcium. 2025 Jan; 2025 Jan 1. PMID: 39746287.", + "Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis. Ogino N, Leite MF, Guerra MT, Kruglov E, Asashima H, Hafler DA, Ito T, Pereira JP, Peiffer BJ, Sun Z, Ehrlich BE, Nathanson MH. J Clin Invest. 2024 Jun 25; 2024 Jun 25. PMID: 38916955.", + "NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells. Sánchez JC, Alemán A, Henao JF, Olaya JC, Ehrlich BE. J Physiol Biochem. 2024 May; 2024 Apr 2. PMID: 38564162.", + "Response to Kochan et al., 2023. Ehrlich BE, Vahdat L, DeCillis AP, Seidman A. Support Care Cancer. 2023 Jul 22; 2023 Jul 22. PMID: 37480366.", + "Calcium signaling in chemotherapy-induced neuropathy. Fonseca MC, Marazzi-Diniz PHS, Leite MF, Ehrlich BE. Cell Calcium. 2023 Jul; 2023 May 20. PMID: 37244172.", + "Location, location, and activation of a channel by calcium. Kuo IY, Ehrlich BE. Proc Natl Acad Sci U S A. 2022 Oct 25; 2022 Oct 10. PMID: 36215521.", + "A preliminary, prospective study of peripheral neuropathy and cognitive function in patients with breast cancer during taxane therapy. Ibrahim EY, Munshani S, Domenicano I, Rodwin R, Nowak RJ, Pusztai L, Lustberg M, Ehrlich BE. PLoS One. 2022; 2022 Oct 7. PMID: 36206298.", + "Boosting ER-mitochondria calcium transfer to treat Wolfram syndrome. Fischer TT, Nguyen LD, Ehrlich BE. Cell Calcium. 2022 Jun; 2022 Mar 24. PMID: 35366518.", + "Biomarkers of Chemotherapy-Induced Peripheral Neuropathy: Current Status and Future Directions. Rodwin RL, Siddiq NZ, Ehrlich BE, Lustberg MB. Front Pain Res (Lausanne). 2022; 2022 Mar 14. PMID: 35360655.", + "Cytoskeletal dynamics regulates stromal invasion behavior of distinct liver cancer subtypes. Nguyen RY, Xiao H, Gong X, Arroyo A, Cabral AT, Fischer TT, Flores KM, Zhang X, Robert ME, Ehrlich BE, Mak M. Commun Biol. 2022 Mar 3; 2022 Mar 3. PMID: 35241781.", + "The Impact of Mutations in Wolframin on Psychiatric Disorders. Munshani S, Ibrahim EY, Domenicano I, Ehrlich BE. Front Pediatr. 2021; 2021 Oct 21. PMID: 34746052.", + "Neuronal calcium sensor 1 (NCS1) dependent modulation of neuronal morphology and development. Fischer TT, Nguyen LD, Ehrlich BE. FASEB J. 2021 Oct. PMID: 34499766.", + "Functional Interaction between Transient Receptor Potential V4 Channel and Neuronal Calcium Sensor 1 and the Effects of Paclitaxel. Sánchez JC, Ehrlich BE. Mol Pharmacol. 2021 Sep; 2021 Jul 28. PMID: 34321341.", + "Pharmacological rescue of cognitive function in a mouse model of chemobrain. Nguyen LD, Fischer TT, Ehrlich BE. Mol Neurodegener. 2021 Jun 26; 2021 Jun 26. PMID: 34174909.", + "Cognitive Effects and Depression Associated With Taxane-Based Chemotherapy in Breast Cancer Survivors: A Meta-Analysis. Ibrahim EY, Domenicano I, Nyhan K, Elfil M, Mougalian SS, Cartmel B, Ehrlich BE. Front Oncol. 2021; 2021 Apr 29. PMID: 33996556.", + "BOK controls apoptosis by Ca(2+) transfer through ER-mitochondrial contact sites. Carpio MA, Means RE, Brill AL, Sainz A, Ehrlich BE, Katz SG. Cell Rep. 2021 Mar 9. PMID: 33691099.", + "Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice. Nguyen LD, Nolte LG, Tan WJT, Giuvelis D, Santos-Sacchi J, Bilsky E, Ehrlich BE. Sci Rep. 2021 Jan 27; 2021 Jan 27. PMID: 33504822.", + "Modulating TRPV4 channels with paclitaxel and lithium. Sánchez JC, Muñoz LV, Ehrlich BE. Cell Calcium. 2020 Nov; 2020 Aug 18. PMID: 32871457.", + "Wolfram Syndrome: a Monogenic Model to Study Diabetes Mellitus and Neurodegeneration. Fischer TT, Ehrlich BE. Curr Opin Physiol. 2020 Oct; 2020 Jul 15. PMID: 32864536.", + "Calpain inhibitor and ibudilast rescue β cell functions in a cellular model of Wolfram syndrome. Nguyen LD, Fischer TT, Abreu D, Arroyo A, Urano F, Ehrlich BE. Proc Natl Acad Sci U S A. 2020 Jul 21; 2020 Jul 6. PMID: 32632005.", + "Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases. Nguyen LD, Ehrlich BE. EMBO Mol Med. 2020 Jun 8; 2020 Apr 29. PMID: 32346964.", + "Contractile work directly modulates mitochondrial protein levels in human engineered heart tissues. Ng R, Sewanan LR, Brill AL, Stankey P, Li X, Qyang Y, Ehrlich BE, Campbell SG. Am J Physiol Heart Circ Physiol. 2020 Jun 1; 2020 May 8. PMID: 32383992.", + "Neuronal Calcium Sensor 1 is up-regulated in response to stress to promote cell survival and motility in cancer cells. Grosshans HK, Fischer TT, Steinle JA, Brill AL, Ehrlich BE. Mol Oncol. 2020 Jun; 2020 Apr 28. PMID: 32239615.", + "Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis. Perry RJ, Zhang D, Guerra MT, Brill AL, Goedeke L, Nasiri AR, Rabin-Court A, Wang Y, Peng L, Dufour S, Zhang Y, Zhang XM, Butrico GM, Toussaint K, Nozaki Y, Cline GW, Petersen KF, Nathanson MH, Ehrlich BE, Shulman GI. Nature. 2020 Mar; 2020 Mar 4. PMID: 32132708.", + "Polycystin 2: A calcium channel, channel partner, and regulator of calcium homeostasis in ADPKD. Brill AL, Ehrlich BE. Cell Signal. 2020 Feb; 2019 Dec 2. PMID: 31805375.", + "Polycystin 2 is increased in disease to protect against stress-induced cell death. Brill AL, Fischer TT, Walters JM, Marlier A, Sewanan LR, Wilson PC, Johnson EK, Moeckel G, Cantley LG, Campbell SG, Nerbonne JM, Chung HJ, Robert ME, Ehrlich BE. Sci Rep. 2020 Jan 15; 2020 Jan 15. PMID: 31941974.", + "Prevention of chemotherapy-induced peripheral neuropathy: A review of recent findings. Ibrahim EY, Ehrlich BE. Crit Rev Oncol Hematol. 2020 Jan; 2019 Nov 13. PMID: 31783290.", + "Characterization of NCS1-InsP3R1 interaction and its functional significance. Nguyen LD, Petri ET, Huynh LK, Ehrlich BE. J Biol Chem. 2019 Dec 6; 2019 Oct 28. PMID: 31659121.", + "O-GlcNAc transferase suppresses necroptosis and liver fibrosis. Zhang B, Li MD, Yin R, Liu Y, Yang Y, Mitchell-Richards KA, Nam JH, Li R, Wang L, Iwakiri Y, Chung D, Robert ME, Ehrlich BE, Bennett AM, Yu J, Nathanson MH, Yang X. JCI Insight. 2019 Nov 1; 2019 Nov 1. PMID: 31672932.", + "Polycystin 2 regulates mitochondrial Ca(2+) signaling, bioenergetics, and dynamics through mitofusin 2. Kuo IY, Brill AL, Lemos FO, Jiang JY, Falcone JL, Kimmerling EP, Cai Y, Dong K, Kaplan DL, Wallace DP, Hofer AM, Ehrlich BE. Sci Signal. 2019 May 7; 2019 May 7. PMID: 31064883.", + "TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells. Arhatte M, Gunaratne GS, El Boustany C, Kuo IY, Moro C, Duprat F, Plaisant M, Duval H, Li D, Picard N, Couvreux A, Duranton C, Rubera I, Pagnotta S, Lacas-Gervais S, Ehrlich BE, Marchant JS, Savage AM, van Eeden FJM, Wilkinson RN, Demolombe S, Honoré E, Patel A. Nat Commun. 2019 May 2; 2019 May 2. PMID: 31048699.", + "Neuronal calcium sensor 1 (NCS1) promotes motility and metastatic spread of breast cancer cells in vitro and in vivo. Apasu JE, Schuette D, LaRanger R, Steinle JA, Nguyen LD, Grosshans HK, Zhang M, Cai WL, Yan Q, Robert ME, Mak M, Ehrlich BE. FASEB J. 2019 Apr; 2018 Dec 28. PMID: 30592625.", + "NCS-1 is a regulator of calcium signaling in health and disease. Boeckel GR, Ehrlich BE. Biochim Biophys Acta Mol Cell Res. 2018 Nov; 2018 May 8. PMID: 29746899.", + "Hepatocellular Carcinoma Outcome Is Predicted by Expression of Neuronal Calcium Sensor 1. Schuette D, Moore LM, Robert ME, Taddei TH, Ehrlich BE. Cancer Epidemiol Biomarkers Prev. 2018 Sep; 2018 May 22. PMID: 29789326.", + "An assessment of neuronal calcium sensor-1 and response to neoadjuvant chemotherapy in breast cancer patients. Moore LM, Wilkinson R, Altan M, Toki M, Carvajal-Hausdorf DE, McGuire J, Ehrlich BE, Rimm DL. NPJ Breast Cancer. 2018; 2018 Mar 12. PMID: 29560416.", + "The prevention of chemotherapy induced peripheral neuropathy by concurrent treatment with drugs used for bipolar disease: a retrospective chart analysis in human cancer patients. Wadia RJ, Stolar M, Grens C, Ehrlich BE, Chao HH. Oncotarget. 2018 Jan 26; 2017 Dec 19. PMID: 29484113.", + "Polycystin and calcium signaling in cell death and survival. Lemos FO, Ehrlich BE. Cell Calcium. 2018 Jan; 2017 May 24. PMID: 28601384.", + "Polycystin 2-dependent cardio-protective mechanisms revealed by cardiac stress. Giehl E, Lemos FO, Huang Y, Giordano FJ, Kuo IY, Ehrlich BE. Pflugers Arch. 2017 Nov; 2017 Jul 31. PMID: 28762163.", + "Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation. Ruan HB, Ma Y, Torres S, Zhang B, Feriod C, Heck RM, Qian K, Fu M, Li X, Nathanson MH, Bennett AM, Nie Y, Ehrlich BE, Yang X. Genes Dev. 2017 Aug 15; 2017 Sep 13. PMID: 28903979.", + "Calcium Sensor, NCS-1, Promotes Tumor Aggressiveness and Predicts Patient Survival. Moore LM, England A, Ehrlich BE, Rimm DL. Mol Cancer Res. 2017 Jul; 2017 Mar 8. PMID: 28275088.", + "Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver. Feriod CN, Oliveira AG, Guerra MT, Nguyen L, Richards KM, Jurczak MJ, Ruan HB, Camporez JP, Yang X, Shulman GI, Bennett AM, Nathanson MH, Ehrlich BE. Hepatol Commun. 2017 Feb; 2016 Nov 11. PMID: 28966992.", + "The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function. Padovano V, Kuo IY, Stavola LK, Aerni HR, Flaherty BJ, Chapin HC, Ma M, Somlo S, Boletta A, Ehrlich BE, Rinehart J, Caplan MJ. Mol Biol Cell. 2017 Jan 15; 2016 Nov 23. PMID: 27881662.", + "Low-dose dasatinib rescues cardiac function in Noonan syndrome. Yi JS, Huang Y, Kwaczala AT, Kuo IY, Ehrlich BE, Campbell SG, Giordano FJ, Bennett AM. JCI Insight. 2016 Dec 8; 2016 Dec 8. PMID: 27942593.", + "Neuronal Calcium Sensor 1 Has Two Variants with Distinct Calcium Binding Characteristics. Wang B, Boeckel GR, Huynh L, Nguyen L, Cao W, De La Cruz EM, Kaftan EJ, Ehrlich BE. PLoS One. 2016; 2016 Aug 30. PMID: 27575489.", + "Structural studies of the C-terminal tail of polycystin-2 (PC2) reveal insights into the mechanisms used for the functional regulation of PC2. Yang Y, Ehrlich BE. J Physiol. 2016 Aug 1; 2016 Apr 27. PMID: 26857659.", + "Decreased Polycystin 2 Levels Result in Non-Renal Cardiac Dysfunction with Aging. Kuo IY, Duong SL, Nguyen L, Ehrlich BE. PLoS One. 2016; 2016 Apr 15. PMID: 27081851.", + "Conformational dynamics of Ca2+-dependent responses in the polycystin-2 C-terminal tail. Yang Y, Hodsdon ME, Lolis EJ, Ehrlich BE. Biochem J. 2016 Feb 1; 2015 Nov 16. PMID: 26574436.", + "Oligomerization of the polycystin-2 C-terminal tail and effects on its Ca2+-binding properties. Yang Y, Keeler C, Kuo IY, Lolis EJ, Ehrlich BE, Hodsdon ME. J Biol Chem. 2015 Apr 17; 2015 Feb 25. PMID: 25716316.", + "The effects of mycoplasma contamination upon the ability to form bioengineered 3D kidney cysts. DesRochers TM, Kuo IY, Kimmerling EP, Ehrlich BE, Kaplan DL. PLoS One. 2015; 2015 Mar 20. PMID: 25793639.", + "Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels. Kuo IY, Hu J, Ha Y, Ehrlich BE. J Biol Chem. 2015 Mar 6; 2015 Jan 21. PMID: 25609250.", + "Signaling in muscle contraction. Kuo IY, Ehrlich BE. Cold Spring Harb Perspect Biol. 2015 Feb 2; 2015 Feb 2. PMID: 25646377.", + "Muscling in on the ryanodine receptor. Kuo IY, Ehrlich BE. Nat Struct Mol Biol. 2015 Feb. PMID: 25650905.", + "Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II. Feriod CN, Nguyen L, Jurczak MJ, Kruglov EA, Nathanson MH, Shulman GI, Bennett AM, Ehrlich BE. Am J Physiol Endocrinol Metab. 2014 Dec 1; 2014 Oct 14. PMID: 25315698.", + "Decreased polycystin 2 expression alters calcium-contraction coupling and changes β-adrenergic signaling pathways. Kuo IY, Kwaczala AT, Nguyen L, Russell KS, Campbell SG, Ehrlich BE. Proc Natl Acad Sci U S A. 2014 Nov 18; 2014 Nov 3. PMID: 25368166.", + "Cyst formation following disruption of intracellular calcium signaling. Kuo IY, DesRochers TM, Kimmerling EP, Nguyen L, Ehrlich BE, Kaplan DL. Proc Natl Acad Sci U S A. 2014 Sep 30; 2014 Sep 16. PMID: 25228769.", + "The number and location of EF hand motifs dictates the calcium dependence of polycystin-2 function. Kuo IY, Keeler C, Corbin R, Ćelić A, Petri ET, Hodsdon ME, Ehrlich BE. FASEB J. 2014 May; 2014 Feb 20. PMID: 24558196.", + "An explicit formulation approach for the analysis of calcium binding to EF-hand proteins using isothermal titration calorimetry. Keeler C, Poon G, Kuo IY, Ehrlich BE, Hodsdon ME. Biophys J. 2013 Dec 17. PMID: 24359756.", + "The role of chromogranin B in an animal model of multiple sclerosis. Mo M, Hoang HT, Schmidt S, Clark RB, Ehrlich BE. Mol Cell Neurosci. 2013 Sep; 2013 Apr 24. PMID: 23624073.", + "Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy. Paavola J, Schliffke S, Rossetti S, Kuo IY, Yuan S, Sun Z, Harris PC, Torres VE, Ehrlich BE. J Mol Cell Cardiol. 2013 May; 2013 Jan 30. PMID: 23376035.", + "Ion channels in renal disease. Kuo IY, Ehrlich BE. Chem Rev. 2012 Dec 12; 2012 Jul 18. PMID: 22809040.", + "Prevention of paclitaxel-induced peripheral neuropathy by lithium pretreatment. Mo M, Erdelyi I, Szigeti-Buck K, Benbow JH, Ehrlich BE. FASEB J. 2012 Nov; 2012 Aug 13. PMID: 22889832.", + "Calcium-induced conformational changes in C-terminal tail of polycystin-2 are necessary for channel gating. Ćelić AS, Petri ET, Benbow J, Hodsdon ME, Ehrlich BE, Boggon TJ. J Biol Chem. 2012 May 18; 2012 Apr 3. PMID: 22474326.", + "Derivation of functional ventricular cardiomyocytes using endogenous promoter sequence from murine embryonic stem cells. Lee MY, Sun B, Schliffke S, Yue Z, Ye M, Paavola J, Bozkulak EC, Amos PJ, Ren Y, Ju R, Jung YW, Ge X, Yue L, Ehrlich BE, Qyang Y. Stem Cell Res. 2012 Jan; 2011 Aug 22. PMID: 22099020.", + "C-terminal domain of chromogranin B regulates intracellular calcium signaling. Schmidt S, Mo M, Heidrich FM, Ćelić A, Ehrlich BE. J Biol Chem. 2011 Dec 30; 2011 Oct 20. PMID: 22016391.", + "High density cultures of embryoid bodies enhanced cardiac differentiation of murine embryonic stem cells. Lee MY, Cagavi Bozkulak E, Schliffke S, Amos PJ, Ren Y, Ge X, Ehrlich BE, Qyang Y. Biochem Biophys Res Commun. 2011 Dec 9; 2011 Nov 6. PMID: 22079290.", + "Protection of neuronal calcium sensor 1 protein in cells treated with paclitaxel. Benbow JH, DeGray B, Ehrlich BE. J Biol Chem. 2011 Oct 7; 2011 Aug 1. PMID: 21808066.", + "Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells. Ren Y, Lee MY, Schliffke S, Paavola J, Amos PJ, Ge X, Ye M, Zhu S, Senyei G, Lum L, Ehrlich BE, Qyang Y. J Mol Cell Cardiol. 2011 Sep; 2011 May 4. PMID: 21569778.", + "Prolonged oxaliplatin exposure alters intracellular calcium signaling: a new mechanism to explain oxaliplatin-associated peripheral neuropathy. Schulze C, McGowan M, Jordt SE, Ehrlich BE. Clin Colorectal Cancer. 2011 Jun; 2011 Apr 22. PMID: 21859566.", + "Isoform-specific regulation of the inositol 1,4,5-trisphosphate receptor by O-linked glycosylation. Bimboese P, Gibson CJ, Schmidt S, Xiang W, Ehrlich BE. J Biol Chem. 2011 May 6; 2011 Mar 7. PMID: 21383013.", + "Paclitaxel accelerates spontaneous calcium oscillations in cardiomyocytes by interacting with NCS-1 and the InsP3R. Zhang K, Heidrich FM, DeGray B, Boehmerle W, Ehrlich BE. J Mol Cell Cardiol. 2010 Nov; 2010 Aug 27. PMID: 20801127.", + "Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity. Petri ET, Celic A, Kennedy SD, Ehrlich BE, Boggon TJ, Hodsdon ME. Proc Natl Acad Sci U S A. 2010 May 18; 2010 May 3. PMID: 20439752.", + "Analysis of the cytoplasmic interaction between polycystin-1 and polycystin-2. Casuscelli J, Schmidt S, DeGray B, Petri ET, Celić A, Folta-Stogniew E, Ehrlich BE, Boggon TJ. Am J Physiol Renal Physiol. 2009 Nov; 2009 Sep 2. PMID: 19726544.", + "Discrete proteolysis of neuronal calcium sensor-1 (NCS-1) by mu-calpain disrupts calcium binding. Blachford C, Celić A, Petri ET, Ehrlich BE. Cell Calcium. 2009 Oct; 2009 Sep 3. PMID: 19732951.", + "Domain mapping of the polycystin-2 C-terminal tail using de novo molecular modeling and biophysical analysis. Celić A, Petri ET, Demeler B, Ehrlich BE, Boggon TJ. J Biol Chem. 2008 Oct 17; 2008 Aug 11. PMID: 18694932.", + "Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2. Geng L, Boehmerle W, Maeda Y, Okuhara DY, Tian X, Yu Z, Choe CU, Anyatonwu GI, Ehrlich BE, Somlo S. Proc Natl Acad Sci U S A. 2008 Oct 14; 2008 Oct 3. PMID: 18836075.", + "Chromogranin B regulates calcium signaling, nuclear factor kappaB activity, and brain natriuretic peptide production in cardiomyocytes. Heidrich FM, Zhang K, Estrada M, Huang Y, Giordano FJ, Ehrlich BE. Circ Res. 2008 May 23; 2008 Apr 17. PMID: 18420944.", + "Inositol 1,4,5-trisphosphate receptor movement is restricted by addition of elevated levels of O-linked sugar. Gibson CJ, Ehrlich BE. Cell Calcium. 2008 Mar; 2007 Jul 3. PMID: 17610951.", + "Regulation of the inositol 1,4,5-trisphosphate receptor type I by O-GlcNAc glycosylation. Rengifo J, Gibson CJ, Winkler E, Collin T, Ehrlich BE. J Neurosci. 2007 Dec 12. PMID: 18077693.", + "Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile. Minagawa N, Nagata J, Shibao K, Masyuk AI, Gomes DA, Rodrigues MA, Lesage G, Akiba Y, Kaunitz JD, Ehrlich BE, Larusso NF, Nathanson MH. Gastroenterology. 2007 Nov; 2007 Aug 14. PMID: 17916355.", + "Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus. Nicolay NH, Hertle D, Boehmerle W, Heidrich FM, Yeckel M, Ehrlich BE. J Neurosci Res. 2007 Jul. PMID: 17471556.", + "Chronic exposure to paclitaxel diminishes phosphoinositide signaling by calpain-mediated neuronal calcium sensor-1 degradation. Boehmerle W, Zhang K, Sivula M, Heidrich FM, Lee Y, Jordt SE, Ehrlich BE. Proc Natl Acad Sci U S A. 2007 Jun 26; 2007 Jun 20. PMID: 17581879.", + "Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2. Anyatonwu GI, Estrada M, Tian X, Somlo S, Ehrlich BE. Proc Natl Acad Sci U S A. 2007 Apr 10; 2007 Apr 2. PMID: 17404231.", + "TRP channels in disease. Jordt SE, Ehrlich BE. Subcell Biochem. 2007. PMID: 18193640.", + "The inositol 1,4,5-trisphosphate receptor (IP3R) and its regulators: sometimes good and sometimes bad teamwork. Choe CU, Ehrlich BE. Sci STKE. 2006 Nov 28; 2006 Nov 28. PMID: 17132820.", + "Paclitaxel induces calcium oscillations via an inositol 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanism. Boehmerle W, Splittgerber U, Lazarus MB, McKenzie KM, Johnston DG, Austin DJ, Ehrlich BE. Proc Natl Acad Sci U S A. 2006 Nov 28; 2006 Nov 17. PMID: 17114292.", + "Elevated testosterone induces apoptosis in neuronal cells. Estrada M, Varshney A, Ehrlich BE. J Biol Chem. 2006 Sep 1; 2006 Jun 27. PMID: 16803879.", + "Calcium signaling in cholangiocytes. Minagawa N, Ehrlich BE, Nathanson MH. World J Gastroenterol. 2006 Jun 14. PMID: 16773703.", + "Neuronal calcium sensor-1 enhancement of InsP3 receptor activity is inhibited by therapeutic levels of lithium. Schlecker C, Boehmerle W, Jeromin A, DeGray B, Varshney A, Sharma Y, Szigeti-Buck K, Ehrlich BE. J Clin Invest. 2006 Jun; 2006 May 11. PMID: 16691292.", + "Ca2+ oscillations induced by testosterone enhance neurite outgrowth. Estrada M, Uhlen P, Ehrlich BE. J Cell Sci. 2006 Feb 15; 2006 Jan 31. PMID: 16449326.", + "Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling. Uhlén P, Burch PM, Zito CI, Estrada M, Ehrlich BE, Bennett AM. Proc Natl Acad Sci U S A. 2006 Feb 14; 2006 Feb 3. PMID: 16461457.", + "Calcium release from ryanodine receptors in the nucleoplasmic reticulum. Marius P, Guerra MT, Nathanson MH, Ehrlich BE, Leite MF. Cell Calcium. 2006 Jan; 2005 Nov 9. PMID: 16289270.", + "Organic cation permeation through the channel formed by polycystin-2. Anyatonwu GI, Ehrlich BE. J Biol Chem. 2005 Aug 19; 2005 Jun 16. PMID: 15961385.", + "Naive CD4+ T cells from lupus-prone Fas-intact MRL mice display TCR-mediated hyperproliferation due to intrinsic threshold defects in activation. Zielinski CE, Jacob SN, Bouzahzah F, Ehrlich BE, Craft J. J Immunol. 2005 Apr 15. PMID: 15814741.", + "Signaling microdomains regulate inositol 1,4,5-trisphosphate-mediated intracellular calcium transients in cultured neurons. Jacob SN, Choe CU, Uhlen P, DeGray B, Yeckel MF, Ehrlich BE. J Neurosci. 2005 Mar 16. PMID: 15772345.", + "", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Eisenstein Lab", + "lab_url": "https://medicine.yale.edu/lab/eisenstein/", + "research_bio": "INFORMATION FOR The focus of the Eisenstein Lab is on the impact of metabolic and environmental factors on the cutaneous immunobiology of the skin in homeostasis and in disequilibrium. Current projects focus on two different disease states, namely how manmade products modulate the immunologic response to allergens and how metabolic factors affect the pathogenesis of hidradenitis suppurativa, a chronic and debilitating, autoinflammatory cutaneous disease. We hope to enhance our understanding of these different pathogenic states and uncover fundamental biology to ultimately improve our treatment and management of patients with allergic and inflammatory disease. The research program in the Eisenstein Lab is focused on environmental factors that affect the pathogenesis of allergic diseases and autoinflammatory diseases. See Dr. Eisenstein's published research. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/eisenstein/publications/", + "publications": [ + "Yale School of Medicine /", + "Dermatology /", + "Research", + "Lab Members", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Lab Members", + "Publications", + "", + "", + "", + "", + "", + "", + "Supplementation with GPR120 (Ffar4) ligand omega-3 does not improve survival in murine sepsis models. Castelo Branco Ramos Nakandakari S, Elliott EI, Fudoli Lins Vieira R, da Silva Rios T, Fosam A, Betim Pavan IC, Maftoum Costa M, Salvino da Silva LG, de Oliveira Ramos C, Rios Gonçalves G, Akingbesote ND, Sidarta-Oliveira D, Moreli AP, Rosseto Braga R, Pinto AP, Eisenstein A, Velloso LA, Simabuco FM, Pauli JR, Rochete Ropelle E, Ramos da Silva AS, Wang A, Perry RJ, Cintra DE. Am J Physiol Endocrinol Metab. 2025 Nov 1; 2025 Sep 12. PMID: 40938960.", + "Food Insecurity and Its Effects on Individuals With Food Allergies and Atopic Dermatitis: A Comprehensive Review. Tripathy K, Brown-Soler I, Eisenstein A. Pediatr Dermatol. 2025 Oct 18; 2025 Oct 18. PMID: 41108626.", + "EGFR-STAT1 pathway drives fibrosis initiation in fibroinflammatory skin diseases. Odell AV, Newton NM, Eisenstein A, Micevic G, Flavell RA, Odell ID. Nat Commun. 2025 Oct 9; 2025 Oct 9. PMID: 41068129.", + "The prevalence of endometriosis in adult female patients with hidradenitis suppurativa: a cross-sectional study using the All of Us Research Program. Hodelin C, Cohen JM, Eisenstein A. Clin Exp Dermatol. 2025 Sep 3; 2025 Sep 3. PMID: 40898779.", + "The association of hidradenitis suppurativa with cigarette smoking and cannabis use: a cross-sectional study in the All of Us Research Program. Chen GF, Shipman WD, Hodelin C, Hsia HC, Cohen JM, Eisenstein A. Clin Exp Dermatol. 2025 Apr 24. PMID: 39573984.", + "Skin damage signals mediate allergic sensitization to spatially unlinked antigen. Waizman DA, Brown-Soler I, Martin AL, Ma Y, Zhou K, Israni-Winger K, Zhang C, Medzhitov R, Launay P, Michieletto MF, Henao-Mejia J, Palm NW, Craft J, Eisenstein A, Wang A. Sci Immunol. 2025 Apr 4; 2025 Apr 4. PMID: 40184440.", + "The art of dermatology: Lessons learned from master morphologist, Irwin M. Braverman, MD. Eisenstein A, Johnston M, Laird M, Perkins S, Siegel J, Watsky K. Clin Dermatol. 2025 Mar-Apr; 2025 Jan 6. PMID: 39778634.", + "Efficacy of laser hair removal in hidradenitis suppurativa: A systematic review and meta-analysis. Shipman WD 3rd, Williams MN, Suozzi KC, Eisenstein AS, Dover JS. Lasers Surg Med. 2024 Jul; 2024 May 20. PMID: 38769894.", + "Associations between hidradenitis suppurativa and asthma and allergic rhinitis: a case-control study in the All of Us research program. Chen GF, Cohen JM, Eisenstein A. Int J Dermatol. 2024 Mar; 2023 Dec 18. PMID: 38108577.", + "Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs. Eisenstein A, Hilliard BK, Pope SD, Zhang C, Taskar P, Waizman DA, Israni-Winger K, Tian H, Luan HH, Wang A. Immunity. 2022 Jun 14; 2022 May 18. PMID: 35588739.", + "Skin-limited Langerhans cell histiocytosis presenting as crusted papules in an acneiform distribution in an adolescent man. Choi R, Ko CJ, Eisenstein A. JAAD Case Rep. 2022 Feb; 2021 Dec 15. PMID: 35036502.", + "Food Allergy: Searching for the Modern Environmental Culprit. Eisenstein AS, Hilliard B, Silwal S, Wang A. Yale J Biol Med. 2020 Dec; 2020 Dec 29. PMID: 33380935.", + "Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis. Eisenstein A, Chitalia SV, Ravid K. Int J Mol Sci. 2020 Oct 10; 2020 Oct 10. PMID: 33050467.", + "Emerging Biomarkers in Cutaneous Melanoma. Eisenstein A, Gonzalez EC, Raghunathan R, Xu X, Wu M, McLean EO, McGee J, Ryu B, Alani RM. Mol Diagn Ther. 2018 Apr. PMID: 29411301.", + "Quantitative assessment of neuropilin-2 as a simple and sensitive diagnostic assay for spitzoid melanocytic lesions. Eisenstein A, Panova IP, Chung HJ, Goldberg LJ, Zhang Q, Lazova R, Bhawan J, Busam KJ, Symanowski JT, Alani RM, Ryu B. Melanoma Res. 2018 Feb. PMID: 29227334.", + "The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases. Eisenstein A, Patterson S, Ravid K. J Cell Physiol. 2015 Dec. PMID: 25975415.", + "An adenosine receptor-Krüppel-like factor 4 protein axis inhibits adipogenesis. Eisenstein A, Carroll SH, Johnston-Cox H, Farb M, Gokce N, Ravid K. J Biol Chem. 2014 Jul 25. PMID: 24928509.", + "The macrophage A2B adenosine receptor regulates tissue insulin sensitivity. Johnston-Cox H, Eisenstein AS, Koupenova M, Carroll S, Ravid K. PLoS One. 2014; 2014 Jun 3. PMID: 24892847.", + "G protein-coupled receptors and adipogenesis: a focus on adenosine receptors. Eisenstein A, Ravid K. J Cell Physiol. 2014 Apr. PMID: 24114647.", + "Integration of basic science and clinical medicine: the innovative approach of the cadaver biopsy project at the Boston University School of Medicine. Eisenstein A, Vaisman L, Johnston-Cox H, Gallan A, Shaffer K, Vaughan D, O'Hara C, Joseph L. Acad Med. 2014 Jan. PMID: 24280854.", + "A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors. Sun Y, Duan Y, Eisenstein AS, Hu W, Quintana A, Lam WK, Wang Y, Wu Z, Ravid K, Huang P. J Cell Sci. 2012 Oct 1; 2012 Jul 5. PMID: 22767505.", + "Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival. Nguyen PL, Ma J, Chavarro JE, Freedman ML, Lis R, Fedele G, Fiore C, Qiu W, Fiorentino M, Finn S, Penney KL, Eisenstein A, Schumacher FR, Mucci LA, Stampfer MJ, Giovannucci E, Loda M. J Clin Oncol. 2010 Sep 1; 2010 Aug 2. PMID: 20679621.", + "Gleason score and lethal prostate cancer: does 3 + 4 = 4 + 3? Stark JR, Perner S, Stampfer MJ, Sinnott JA, Finn S, Eisenstein AS, Ma J, Fiorentino M, Kurth T, Loda M, Giovannucci EL, Rubin MA, Mucci LA. J Clin Oncol. 2009 Jul 20; 2009 May 11. PMID: 19433685.", + "Testing a multigene signature of prostate cancer death in the Swedish Watchful Waiting Cohort. Mucci LA, Pawitan Y, Demichelis F, Fall K, Stark JR, Adami HO, Andersson SO, Andrén O, Eisenstein A, Holmberg L, Huang W, Kantoff PW, Kim R, Perner S, Stampfer MJ, Johansson JE, Rubin MA. Cancer Epidemiol Biomarkers Prev. 2008 Jul; 2008 Jun 26. PMID: 18583469.", + "Nine-gene molecular signature is not associated with prostate cancer death in a watchful waiting cohort. Mucci LA, Pawitan Y, Demichelis F, Fall K, Stark JR, Adami HO, Andersson SO, Andrén O, Eisenstein AS, Holmberg L, Huang W, Kantoff PW, Perner S, Stampfer MJ, Johansson JE, Rubin MA. Cancer Epidemiol Biomarkers Prev. 2008 Jan. PMID: 18199732.", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Electro-Biology and Arrhythmia Therapeutics Laboratory", + "lab_url": "https://medicine.yale.edu/lab/akar/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/akar/publications/", + "publications": null + }, + { + "lab_name": "Engelman Lab", + "lab_url": "https://medicine.yale.edu/lab/engelman/", + "research_bio": "INFORMATION FOR Copy Link We are interested in how the primary sequences of membrane proteins determine their three dimensional structures, and hence their functions. The folding of integral membrane proteins clearly differs from that of soluble proteins since the membrane environment imposes constraints on polypeptide secondary and tertiary structural features quite different from those imposed by an aqueous environment. A conceptual underpinning for much of the work in the group is that, for helical transmembrane proteins, the protein folding process can be considered to occur in two kinetically separated and therefore energetically distinct stages. First, transbilayer alpha-helices are formed (stage I) and second, the helices interact within the bilayer to form a specific globular tertiary structure (stage II). In the case of oligomerization events, monomeric proteins are synthesized and inserted into the membrane, and these monomers subsequently interact in a side-to-side fashion to form complexes that involve helix-helix interactions similar to those found within polytopic helical membrane proteins. Our most recent work in this area is to examine the association of transmembrane domains (TMs) involved in signaling by receptors that have a single TM, where the signaling mechanism is mediated by TM interaction. Copy Link We have previously observed the spontaneous, pH-dependent insertion of a water-soluble peptide to form a helix across lipid bilayers. We have now used a related peptide, pH (low) insertion peptide (pHLIP), to translocate cargo molecules attached to its C terminus across the plasma membranes of living cells. Translocation is selective for low pH, and various types of cargo molecules attached by disulfides can be released by reduction in the cytoplasm, including peptide nucleic acids, a cyclic peptide (phalloidin), and organic compounds. Because a high extracellular acidity is characteristic of a variety of pathological conditions (such as tumors, infarcts, stroke-afflicted tissue, atherosclerotic lesions, sites of inflammation or infection, or damaged tissue resulting from trauma), the pH (low) insertion peptide may prove a useful tool for selective delivery of agents for drug therapy, diagnostic imaging, genetic control, or cell regulation. We have recently shown that pHLIP can localize and map acidic foci in kidneys, tumors and inflammatory sites in vivo. In a mouse breast adenocarcinoma model, fluorescently labeled pHLIP finds solid acidic tumors with high accuracy and accumulates in them even at a very early stage of tumor development. The peptide has three states: soluble in water, bound to the surface of a membrane, and inserted across the membrane as an alpha-helix. At physiological pH, the equilibrium is toward water, which explains its low affinity for cells in healthy tissue; at acidic pH, titration of Asp residues shifts the equilibrium toward membrane insertion and tissue accumulation. The pHLIP technology introduces a new concept to detect, target, and possibly treat acidic diseased tissue by employing the selective insertion and folding of membrane peptides. We are continuing our work on the fundamental mechanism and capabilities of the pHLIP technology. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/engelman/pubs/", + "publications": null + }, + { + "lab_name": "Erson Lab", + "lab_url": "https://medicine.yale.edu/lab/erson/", + "research_bio": "INFORMATION FOR We are a new and growing team working on primary brain tumor genomics at Yale University Department of Neurosurgery. We work with: to better understand the interaction between the molecular background and how the tumors form, evolve, transform and respond or resist to treatment. We also work on individual cases of various types of brain tumors to guide the precision medicine efforts using cutting edge computational approaches. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Escobar-Hoyos Lab", + "lab_url": "https://medicine.yale.edu/lab/escobar-hoyos/", + "research_bio": "INFORMATION FOR Copy Link Despite recent targeted- and immune-therapies that have benefitted other cancer types, pancreatic and lung tumors develop therapy resistance. Therefore, there is an urgent clinical need to better understand the molecular biology of this disease to enable the improvement of therapeutic strategies.Activating mutations in KRAS and p53 co-occur in 40% of pancreatic and lung and other tumors. We recelty addressed the long-standing question of how these most common co-occurring mutations in human cancers cooperate to cause tumors, hoping to identify a meaningful therapeutic opportunity. We demonstrated that altered RNA splicing by mutant p53 activates and maintains oncogenic KRAS signaling. These paradigm shifting studies led to discovering that oncogenic KRAS is susceptible to inactivation, a novel finding in the field, and suggested the likelihood that inhibiting RNA splicing represents a valuable therapeutic strategy for mutant KRAS/p53 tumors (Cancer Cell 2020). Therefore, our research focuses on understanding how aberrant RNA splicing contributes to the maintenance, establishment, and impairment of anti-tumor immune response in tumors. Additionally, we aim to test our novel developed therapy, called Splicing-Hit Oligonucleotide Therapy (SHOT), which corrects the RNA splicing errors selectively killing PDAC and LUAD cells of our own genetically engineered mouse models (GEMM) to recapitulate the human PDAC background and to validate our findings. Compared to traditional targeted therapies where it takes years to generate a compound or antibody to inhibit mutant proteins, SHOT enables rapid and precise therapy development. SHOTs are adaptable and scalable, to be used against second-line therapy resistant cancers or to target more than one cancer type. Our laboratory collaborates actively with laboratories at Yale University, Stony Brook University, and Memorial Sloan Kettering Cancer Center. Our team involves experts within backgrounds spanning oncology, immunology, bioinformatics, drug delivery, and microbiology. We believe that through this collaborative environment, we will achieve our ultimate goals in hopes of developing new efficient therapies that can ultimately lead to the cure of this devastating malignancy. Copy Link ", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Ferguson Lab", + "lab_url": "https://medicine.yale.edu/lab/ferguson/", + "research_bio": "INFORMATION FOR Lysosomes have long been recognized as organelles that are responsible for macromolecule degradation and the clearance from cells of pathogens, damaged organelles and protein aggregates. Although such functions of lysosomes are important in all eukaryotic cells, long-lived cells such as neurons are especially dependent on optimal levels of lysosome function to prevent the accumulation of damaged macromolecules. Indeed, failure to clear misfolded proteins and damaged organelles is observed across multiple neurodegenerative diseases. In addition to neurons, another class of cells that are particularly dependent on robust lysosome function are professional scavengers such as macrophages and microglia that ingest huge amounts of material that must be broken down within their lysosomes. Although these critical degradative functions of lysosomes are well established, it has more recently become clear that lysosomes are also an important hub that coordinates signals that match cell growth and physiology with nutrient availability. With this growing appreciation of the roles played by lysosomes in health and disease, we ultimately seek to address the following fundamental questions: To address these questions, we combine live cell imaging to monitor the dynamic recruitment of proteins to lysosomes with proteomic approaches to define the molecular basis for this recruitment and high-throughput siRNA screening to identify new mechanisms controlling lysosomal homeostasis. We seek to place these findings in a physiological context through analysis of mouse models of neurodegenerative disease. With the advent of robust protocols for the differentiation of human induced pluripotent stem cells (iPSCs) to neurons combined with CRISPR-based tools for genome editing, we are increasingly using human neurons as a model system to investigate both the physiological functions of lysosome as well as their contributions to neurodegenerative disease. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/ferguson/pubs/", + "publications": [ + "Yale School of Medicine /", + "Cell Biology /", + "Research Projects Lysosome homeostasis Birt-Hogg-Dubé Syndrome Neuronal ceroid lipofuscinosis Frontotemporal dementia Axonal Lysosome dysfunction", + "Lysosome homeostasis", + "Birt-Hogg-Dubé Syndrome", + "Neuronal ceroid lipofuscinosis", + "Frontotemporal dementia", + "Axonal Lysosome dysfunction", + "Open Positions", + "Multimedia", + "Contact Us", + "Publications", + "Lab Members", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research Projects", + "Multimedia", + "Publications", + "Lab Members", + "Open Positions", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Derailed degradation: LRRK2-dependent exocytosis in Parkinson's disease. Ferguson SM. Proc Natl Acad Sci U S A. 2025 Aug 12; 2025 Aug 4. PMID: 40758897.", + "JIP4 deficiency causes a lysosomal storage disease arising from impaired cystine efflux. Nassar LM, Shi X, Roczniak-Ferguson A, Shen H, Ferguson SM. bioRxiv. 2025 Jun 8; 2025 Jun 8. PMID: 40661466.", + "The bridge-like lipid transport protein VPS13C/PARK23 mediates ER-lysosome contacts following lysosome damage. Wang X, Xu P, Bentley-DeSousa A, Hancock-Cerutti W, Cai S, Johnson BT, Tonelli F, Shao L, Talaia G, Alessi DR, Ferguson SM, De Camilli P. Nat Cell Biol. 2025 May; 2025 Apr 10. PMID: 40211074.", + "LRRK2, lysosome damage, and Parkinson's disease. Bentley-DeSousa A, Clegg D, Ferguson SM. Curr Opin Cell Biol. 2025 Apr; 2025 Feb 20. PMID: 39983584.", + "Same data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology. Gould E, Fraser HS, Parker TH, Nakagawa S, Griffith SC, Vesk PA, Fidler F, Hamilton DG, Abbey-Lee RN, Abbott JK, Aguirre LA, Alcaraz C, Aloni I, Altschul D, Arekar K, Atkins JW, Atkinson J, Baker CM, Barrett M, Bell K, Bello SK, Beltrán I, Berauer BJ, Bertram MG, Billman PD, Blake CK, Blake S, Bliard L, Bonisoli-Alquati A, Bonnet T, Bordes CNM, Bose APH, Botterill-James T, Boyd MA, Boyle SA, Bradfer-Lawrence T, Bradham J, Brand JA, Brengdahl MI, Bulla M, Bussière L, Camerlenghi E, Campbell SE, Campos LLF, Caravaggi A, Cardoso P, Carroll CJW, Catanach TA, Chen X, Chik HYJ, Choy ES, Christie AP, Chuang A, Chunco AJ, Clark BL, Contina A, Covernton GA, Cox MP, Cressman KA, Crotti M, Crouch CD, D'Amelio PB, de Sousa AA, Döbert TF, Dobler R, Dobson AJ, Doherty TS, Drobniak SM, Duffy AG, Duncan AB, Dunn RP, Dunning J, Dutta T, Eberhart-Hertel L, Elmore JA, Elsherif MM, English HM, Ensminger DC, Ernst UR, Ferguson SM, Fernandez-Juricic E, Ferreira-Arruda T, Fieberg J, Finch EA, Fiorenza EA, Fisher DN, Fontaine A, Forstmeier W, Fourcade Y, Frank GS, Freund CA, Fuentes-Lillo E, Gandy SL, Gannon DG, García-Cervigón AI, Garretson AC, Ge X, Geary WL, Géron C, Gilles M, Girndt A, Gliksman D, Goldspiel HB, Gomes DGE, Good MK, Goslee SC, Gosnell JS, Grames EM, Gratton P, Grebe NM, Greenler SM, Griffioen M, Griffith DM, Griffith FJ, Grossman JJ, Güncan A, Haesen S, Hagan JG, Hager HA, Harris JP, Harrison ND, Hasnain SS, Havird JC, Heaton AJ, Herrera-Chaustre ML, Howard TJ, Hsu BY, Iannarilli F, Iranzo EC, Iverson ENK, Jimoh SO, Johnson DH, Johnsson M, Jorna J, Jucker T, Jung M, Kačergytė I, Kaltz O, Ke A, Kelly CD, Keogan K, Keppeler FW, Killion AK, Kim D, Kochan DP, Korsten P, Kothari S, Kuppler J, Kusch JM, Lagisz M, Lalla KM, Larkin DJ, Larson CL, Lauck KS, Lauterbur ME, Law A, Léandri-Breton DJ, Lembrechts JJ, L'Herpiniere K, Lievens EJP, de Lima DO, Lindsay S, Luquet M, MacLeod R, Macphie KH, Magellan K, Mair MM, Malm LE, Mammola S, Mandeville CP, Manhart M, Manrique-Garzon LM, Mäntylä E, Marchand P, Marshall BM, Martin CA, Martin DA, Martin JM, Martinig AR, McCallum ES, McCauley M, McNew SM, Meiners SJ, Merkling T, Michelangeli M, Moiron M, Moreira B, Mortensen J, Mos B, Muraina TO, Murphy PW, Nelli L, Niemelä P, Nightingale J, Nilsonne G, Nolazco S, Nooten SS, Novotny JL, Olin AB, Organ CL, Ostevik KL, Palacio FX, Paquet M, Parker DJ, Pascall DJ, Pasquarella VJ, Paterson JH, Payo-Payo A, Pedersen KM, Perez G, Perry KI, Pottier P, Proulx MJ, Proulx R, Pruett JL, Ramananjato V, Randimbiarison FT, Razafindratsima OH, Rennison DJ, Riva F, Riyahi S, Roast MJ, Rocha FP, Roche DG, Román-Palacios C, Rosenberg MS, Ross J, Rowland FE, Rugemalila D, Russell AL, Ruuskanen S, Saccone P, Sadeh A, Salazar SM, Sales K, Salmón P, Sánchez-Tójar A, Santos LP, Santostefano F, Schilling HT, Schmidt M, Schmoll T, Schneider AC, Schrock AE, Schroeder J, Schtickzelle N, Schultz NL, Scott DA, Scroggie MP, Shapiro JT, Sharma N, Shearer CL, Simón D, Sitvarin MI, Skupien FL, Slinn HL, Smith GP, Smith JA, Sollmann R, Whitney KS, Still SM, Stuber EF, Sutton GF, Swallow B, Taff CC, Takola E, Tanentzap AJ, Tarjuelo R, Telford RJ, Thawley CJ, Thierry H, Thomson J, Tidau S, Tompkins EM, Tortorelli CM, Trlica A, Turnell BR, Urban L, Van de Vondel S, van der Wal JEM, Van Eeckhoven J, van Oordt F, Vanderwel KM, Vanderwel MC, Vanderwolf KJ, Vélez J, Vergara-Florez DC, Verrelli BC, Vieira MV, Villamil N, Vitali V, Vollering J, Walker J, Walker XJ, Walter JA, Waryszak P, Weaver RJ, Wedegärtner REM, Weller DL, Whelan S, White RL, Wolfson DW, Wood A, Yanco SW, Yen JDL, Youngflesh C, Zilio G, Zimmer C, Zimmerman GM, Zitomer RA. BMC Biol. 2025 Feb 6; 2025 Feb 6. PMID: 39915771.", + "A STING-CASM-GABARAP pathway activates LRRK2 at lysosomes. Bentley-DeSousa A, Roczniak-Ferguson A, Ferguson SM. J Cell Biol. 2025 Feb 3; 2025 Jan 15. PMID: 39812709.", + "Lysosomal TBK1 responds to amino acid availability to relieve Rab7-dependent mTORC1 inhibition. Talaia G, Bentley-DeSousa A, Ferguson SM. EMBO J. 2024 Sep; 2024 Aug 5. PMID: 39103493.", + "Intracellular calcium links milk stasis to lysosome-dependent cell death during early mammary gland involution. Jeong J, Lee J, Talaia G, Kim W, Song J, Hong J, Yoo K, Gonzalez DG, Athonvarangkul D, Shin J, Dann P, Haberman AM, Kim LK, Ferguson SM, Choi J, Wysolmerski J. Cell Mol Life Sci. 2024 Jan 12; 2024 Jan 12. PMID: 38212474.", + "Lysosomal TBK1 Responds to Amino Acid Availability to Relieve Rab7-Dependent mTORC1 Inhibition. Talaia G, Bentley-DeSousa A, Ferguson SM. bioRxiv. 2023 Dec 17; 2023 Dec 17. PMID: 38168426.", + "A kinesin-1 adaptor complex controls bimodal slow axonal transport of spectrin in Caenorhabditis elegans. Glomb O, Swaim G, Munoz LLancao P, Lovejoy C, Sutradhar S, Park J, Wu Y, Cason SE, Holzbaur ELF, Hammarlund M, Howard J, Ferguson SM, Gramlich MW, Yogev S. Dev Cell. 2023 Oct 9; 2023 Sep 25. PMID: 37751746.", + "LRRK2 suppresses lysosome degradative activity in macrophages and microglia through MiT-TFE transcription factor inhibition. Yadavalli N, Ferguson SM. Proc Natl Acad Sci U S A. 2023 Aug; 2023 Jul 24. PMID: 37487100.", + "Cab45 deficiency leads to the mistargeting of progranulin and prosaposin and aberrant lysosomal positioning. Tran ML, Tüshaus J, Kim Y, Ramazanov BR, Devireddy S, Lichtenthaler SF, Ferguson SM, von Blume J. Traffic. 2023 Jan. PMID: 36398980.", + "ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling. Hancock-Cerutti W, Wu Z, Xu P, Yadavalli N, Leonzino M, Tharkeshwar AK, Ferguson SM, Shadel GS, De Camilli P. J Cell Biol. 2022 Jul 4; 2022 Jun 3. PMID: 35657605.", + "Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo. Devireddy S, Ferguson SM. J Cell Biol. 2022 Feb 7; 2021 Dec 17. PMID: 34919127.", + "JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton. Rafiq NM, Lyons LL, Gowrishankar S, De Camilli P, Ferguson SM. Commun Biol. 2022 Jan 10; 2022 Jan 10. PMID: 35013510.", + "TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism. Alesi N, Akl EW, Khabibullin D, Liu HJ, Nidhiry AS, Garner ER, Filippakis H, Lam HC, Shi W, Viswanathan SR, Morroni M, Ferguson SM, Henske EP. Nat Commun. 2021 Jul 12; 2021 Jul 12. PMID: 34253722.", + "Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons. Gowrishankar S, Lyons L, Rafiq NM, Roczniak-Ferguson A, De Camilli P, Ferguson SM. Mol Biol Cell. 2021 May 15; 2021 Mar 31. PMID: 33788575.", + "PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease. Nackenoff AG, Hohman TJ, Neuner SM, Akers CS, Weitzel NC, Shostak A, Ferguson SM, Mobley B, Bennett DA, Schneider JA, Jefferson AL, Kaczorowski CC, Schrag MS. PLoS Genet. 2021 Apr; 2021 Apr 8. PMID: 33830999.", + "Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids. Talaia G, Amick J, Ferguson SM. Proc Natl Acad Sci U S A. 2021 Feb 23. PMID: 33597295.", + "Coordination of Rheb lysosomal membrane interactions with mTORC1 activation. Angarola B, Ferguson SM. F1000Res. 2020; 2020 May 27. PMID: 32518628.", + "PQLC2 recruits the C9orf72 complex to lysosomes in response to cationic amino acid starvation. Amick J, Tharkeshwar AK, Talaia G, Ferguson SM. J Cell Biol. 2020 Jan 6. PMID: 31851326.", + "Weak membrane interactions allow Rheb to activate mTORC1 signaling without major lysosome enrichment. Angarola B, Ferguson SM. Mol Biol Cell. 2019 Oct 15; 2019 Sep 18. PMID: 31532697.", + "Pleiotropic requirements for human TDP-43 in the regulation of cell and organelle homeostasis. Roczniak-Ferguson A, Ferguson SM. Life Sci Alliance. 2019 Oct; 2019 Sep 16. PMID: 31527135.", + "Neuronal lysosomes. Ferguson SM. Neurosci Lett. 2019 Apr 1; 2018 Apr 4. PMID: 29626653.", + "Lysosomes Dare Cells to be Different(iated). Roczniak-Ferguson A, Ferguson SM. Cell Stem Cell. 2019 Feb 7. PMID: 30735644.", + "WDR41 supports lysosomal response to changes in amino acid availability. Amick J, Tharkeshwar AK, Amaya C, Ferguson SM. Mol Biol Cell. 2018 Sep 1; 2018 Jul 11. PMID: 29995611.", + "GATOR1-dependent recruitment of FLCN-FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids. Meng J, Ferguson SM. J Cell Biol. 2018 Aug 6; 2018 May 30. PMID: 29848618.", + "Axonal transport and maturation of lysosomes. Ferguson SM. Curr Opin Neurobiol. 2018 Aug; 2018 Mar 9. PMID: 29529416.", + "The complex relationship between TFEB transcription factor phosphorylation and subcellular localization. Puertollano R, Ferguson SM, Brugarolas J, Ballabio A. EMBO J. 2018 Jun 1; 2018 May 15. PMID: 29764979.", + "Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay. Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, Farese RV Jr. Proc Natl Acad Sci U S A. 2018 Mar 20; 2018 Mar 6. PMID: 29511098.", + "Organelles in metabolism and stress responses. Ferguson SM, Henne WM. Mol Biol Cell. 2018 Mar 15. PMID: 29535175.", + "Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology. Gowrishankar S, Wu Y, Ferguson SM. J Cell Biol. 2017 Oct 2; 2017 Aug 7. PMID: 28784610.", + "B-cell non-Hodgkin lymphoma: Selective vulnerability to PIKFYVE inhibition. Gayle S, Landrette S, Beeharry N, Conrad C, Hernandez M, Beckett P, Ferguson SM, Xu T, Rothberg J, Lichenstein H. Autophagy. 2017 Jun 3; 2017 Mar 28. PMID: 28350209.", + "C9orf72: At the intersection of lysosome cell biology and neurodegenerative disease. Amick J, Ferguson SM. Traffic. 2017 May; 2017 Mar 23. PMID: 28266105.", + "Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma. Gayle S, Landrette S, Beeharry N, Conrad C, Hernandez M, Beckett P, Ferguson SM, Mandelkern T, Zheng M, Xu T, Rothberg J, Lichenstein H. Blood. 2017 Mar 30; 2017 Jan 19. PMID: 28104689.", + "A lentiviral system for efficient knockdown of proteins in neuronal cultures [version 1; referees: 2 approved]. Ritter B, Ferguson SM, De Camilli P, McPherson PS. MNI Open Res. 2017; 2017 Dec 5. PMID: 29355247.", + "C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling. Amick J, Roczniak-Ferguson A, Ferguson SM. Mol Biol Cell. 2016 Oct 15; 2016 Aug 24. PMID: 27559131.", + "Phagocytosis Enhances Lysosomal and Bactericidal Properties by Activating the Transcription Factor TFEB. Gray MA, Choy CH, Dayam RM, Ospina-Escobar E, Somerville A, Xiao X, Ferguson SM, Botelho RJ. Curr Biol. 2016 Aug 8; 2016 Jul 7. PMID: 27397893.", + "Lysosomes relax in the cellular suburbs. Gowrishankar S, Ferguson SM. J Cell Biol. 2016 Mar 14. PMID: 26975848.", + "MEDICINE. Membrane traffic en route to cancer. Ferguson SM. Science. 2015 Oct 9. PMID: 26450197.", + "Beyond indigestion: emerging roles for lysosome-based signaling in human disease. Ferguson SM. Curr Opin Cell Biol. 2015 Aug; 2015 May 15. PMID: 25950843.", + "Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques. Gowrishankar S, Yuan P, Wu Y, Schrag M, Paradise S, Grutzendler J, De Camilli P, Ferguson SM. Proc Natl Acad Sci U S A. 2015 Jul 14; 2015 Jun 29. PMID: 26124111.", + "Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes. Willinger T, Staron M, Ferguson SM, De Camilli P, Flavell RA. Proc Natl Acad Sci U S A. 2015 Apr 7; 2015 Mar 23. PMID: 25831514.", + "Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts. Shin NY, Choi H, Neff L, Wu Y, Saito H, Ferguson SM, De Camilli P, Baron R. J Cell Biol. 2014 Oct 13; 2014 Oct 6. PMID: 25287300.", + "A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis. Wu Y, O'Toole ET, Girard M, Ritter B, Messa M, Liu X, McPherson PS, Ferguson SM, De Camilli P. Elife. 2014 Jun 24; 2014 Jun 24. PMID: 24963135.", + "Dynamin 2-dependent endocytosis is required for sustained S1PR1 signaling. Willinger T, Ferguson SM, Pereira JP, De Camilli P, Flavell RA. J Exp Med. 2014 Apr 7; 2014 Mar 17. PMID: 24638168.", + "Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis. Lee MY, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano AK, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood DA, Ferguson SM, De Camilli P, Sessa WC. Development. 2014 Apr; 2014 Mar 5. PMID: 24598168.", + "Essential function of dynamin in the invasive properties and actin architecture of v-Src induced podosomes/invadosomes. Destaing O, Ferguson SM, Grichine A, Oddou C, De Camilli P, Albiges-Rizo C, Baron R. PLoS One. 2013; 2013 Dec 9. PMID: 24348990.", + "Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors. Park RJ, Shen H, Liu L, Liu X, Ferguson SM, De Camilli P. J Cell Sci. 2013 Nov 15; 2013 Sep 17. PMID: 24046449.", + "Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases. Petit CS, Roczniak-Ferguson A, Ferguson SM. J Cell Biol. 2013 Sep 30. PMID: 24081491.", + "Role of dynamin, synaptojanin, and endophilin in podocyte foot processes. Soda K, Balkin DM, Ferguson SM, Paradise S, Milosevic I, Giovedi S, Volpicelli-Daley L, Tian X, Wu Y, Ma H, Son SH, Zheng R, Moeckel G, Cremona O, Holzman LB, De Camilli P, Ishibe S. J Clin Invest. 2012 Dec; 2012 Nov 26. PMID: 23187129.", + "The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Roczniak-Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B, Walther TC, Ferguson SM. Sci Signal. 2012 Jun 12; 2012 Jun 12. PMID: 22692423.", + "Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane. Sousa LP, Lax I, Shen H, Ferguson SM, De Camilli P, Schlessinger J. Proc Natl Acad Sci U S A. 2012 Mar 20; 2012 Feb 27. PMID: 22371560.", + "Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses. Lou X, Fan F, Messa M, Raimondi A, Wu Y, Looger LL, Ferguson SM, De Camilli P. Proc Natl Acad Sci U S A. 2012 Feb 21; 2012 Jan 30. PMID: 22308498.", + "Dynamin, a membrane-remodelling GTPase. Ferguson SM, De Camilli P. Nat Rev Mol Cell Biol. 2012 Jan 11; 2012 Jan 11. PMID: 22233676.", + "Overlapping role of dynamin isoforms in synaptic vesicle endocytosis. Raimondi A, Ferguson SM, Lou X, Armbruster M, Paradise S, Giovedi S, Messa M, Kono N, Takasaki J, Cappello V, O'Toole E, Ryan TA, De Camilli P. Neuron. 2011 Jun 23. PMID: 21689597.", + "Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin. Shen H, Ferguson SM, Dephoure N, Park R, Yang Y, Volpicelli-Daley L, Gygi S, Schlessinger J, De Camilli P. Mol Biol Cell. 2011 Feb 15; 2010 Dec 17. PMID: 21169560.", + "Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits. Ferguson SM, Raimondi A, Paradise S, Shen H, Mesaki K, Ferguson A, Destaing O, Ko G, Takasaki J, Cremona O, O' Toole E, De Camilli P. Dev Cell. 2009 Dec. PMID: 20059951.", + "Selective saturation of slow endocytosis at a giant glutamatergic central synapse lacking dynamin 1. Lou X, Paradise S, Ferguson SM, De Camilli P. Proc Natl Acad Sci U S A. 2008 Nov 11; 2008 Nov 5. PMID: 18987309.", + "Cell- and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neurons. Hayashi M, Raimondi A, O'Toole E, Paradise S, Collesi C, Cremona O, Ferguson SM, De Camilli P. Proc Natl Acad Sci U S A. 2008 Feb 12; 2008 Feb 4. PMID: 18250322.", + "A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. Ferguson SM, Brasnjo G, Hayashi M, Wölfel M, Collesi C, Giovedi S, Raimondi A, Gong LW, Ariel P, Paradise S, O'toole E, Flavell R, Cremona O, Miesenböck G, Ryan TA, De Camilli P. Science. 2007 Apr 27. PMID: 17463283.", + "Boyer Center for Molecular Medicine 295 Congress Avenue New Haven, CT 06510", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Fernandez Lab", + "lab_url": "https://medicine.yale.edu/lab/fernandez/", + "research_bio": "INFORMATION FOR Our lab collaborates with investigators at Yale University and around the world to find genetic clues in multiple neuropsychiatric disorders, including: Ourresearch projectshelp us better understand the biology of these disorders. This knowledge is required for better diagnosis and treatment, which will improve the lives of those who suffer from these conditions. Would you like to participate in our research? Pleaselet us know about your interest. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/fernandez/publications/", + "publications": [ + "Yale School of Medicine /", + "Child Study Center /", + "Research", + "News", + "Participate", + "People", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Participate", + "People", + "Publications", + "News", + "", + "", + "", + "", + "", + "", + "Motor stereotypies in toddlers with and without autism: A transdiagnostic dimension. Chawarska K, Fernandez TV, Milgramm A, Volkmar F, Torres-Viso M, Powell K, Vernetti A, Macari S, Morgan C. J Child Psychol Psychiatry. 2025 Aug 4; 2025 Aug 4. PMID: 40757458.", + "Investigating the familiality of trichotillomania and excoriation disorder. Chen D, Farhat LC, Lebowitz ER, Silverman WK, Bloch MH, Fernandez TV, Olfson E. Psychiatry Res. 2025 Aug; 2025 May 24. PMID: 40449230.", + "Understanding Motor Stereotypies as a Transdiagnostic Phenotype. Garrido-Torres N, Carney AG, Lyons M, Macari S, Morgan C, Powell K, Torres-Viso M, Vernetti A, Chawarska K, Fernandez TV. J Am Acad Child Adolesc Psychiatry. 2025 Aug; 2025 Mar 14. PMID: 40090545.", + "Interneuron Loss and Microglia Activation by Transcriptome Analyses in the Basal Ganglia of Tourette Disorder. Wang Y, Fasching L, Wu F, Suvakov M, Huttner A, Berretta S, Roberts R, Leckman JF, Fernandez TV, Abyzov A, Vaccarino FM. Biol Psychiatry. 2025 Aug 1; 2025 Jan 30. PMID: 39892689.", + "Review: Child Psychiatry in the Era of Genomics: The Promise of Translational Genetics Research for the Clinic. Fitzpatrick SE, Antony I, Nurmi EL, Fernandez TV, Chung WK, Brownstein CA, Gonzalez-Heydrich J, Gur RE, Merner AR, Lázaro-Muñoz G, State MW, Simon KM, Hoffman EJ. JAACAP Open. 2025 Jun; 2024 Aug 9. PMID: 40520982.", + "Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. Strom NI, Gerring ZF, Galimberti M, Yu D, Halvorsen MW, Abdellaoui A, Rodriguez-Fontenla C, Sealock JM, Bigdeli T, Coleman JR, Mahjani B, Thorp JG, Bey K, Burton CL, Luykx JJ, Zai G, Alemany S, Andre C, Askland KD, Bäckman J, Banaj N, Barlassina C, Nissen JB, Bienvenu OJ, Black D, Bloch MH, Børte S, Bosch R, Breen M, Brennan BP, Brentani H, Buxbaum JD, Bybjerg-Grauholm J, Byrne EM, Cabana-Dominguez J, Camarena B, Camarena A, Cappi C, Carracedo A, Casas M, Cavallini MC, Ciullo V, Cook EH, Crosby J, Cullen BA, De Schipper EJ, Delorme R, Djurovic S, Elias JA, Estivill X, Falkenstein MJ, Fundin BT, Garner L, Gironda C, Goes FS, Grados MA, Grove J, Guo W, Haavik J, Hagen K, Harrington K, Havdahl A, Höffler KD, Hounie AG, Hucks D, Hultman C, Janecka M, Jenike E, Karlsson EK, Kelley K, Klawohn J, Krasnow JE, Krebs K, Lange C, Lanzagorta N, Levey D, Lindblad-Toh K, Macciardi F, Maher B, Mathes B, McArthur E, McGregor N, McLaughlin NC, Meier S, Miguel EC, Mulhern M, Nestadt PS, Nurmi EL, O'Connell KS, Osiecki L, Ousdal OT, Palviainen T, Pedersen NL, Piras F, Piras F, Potluri S, Rabionet R, Ramirez A, Rauch S, Reichenberg A, Riddle MA, Ripke S, Rosário MC, Sampaio AS, Schiele MA, Skogholt AH, Sloofman LG, Smit J, Artigas MS, Thomas LF, Tifft E, Vallada H, van Kirk N, Veenstra-VanderWeele J, Vulink NN, Walker CP, Wang Y, Wendland JR, Winsvold BS, Yao Y, Zhou H, Agrawal A, Alonso P, Berberich G, Bucholz KK, Bulik CM, Cath D, Denys D, Eapen V, Edenberg H, Falkai P, Fernandez TV, Fyer AJ, Gaziano JM, Geller DA, Grabe HJ, Greenberg BD, Hanna GL, Hickie IB, Hougaard DM, Kathmann N, Kennedy J, Lai D, Landén M, Hellard SL, Leboyer M, Lochner C, McCracken JT, Medland SE, Mortensen PB, Neale BM, Nicolini H, Nordentoft M, Pato M, Pato C, Pauls DL, Piacentini J, Pittenger C, Posthuma D, Ramos-Quiroga JA, Rasmussen SA, Richter MA, Rosenberg DR, Ruhrmann S, Samuels JF, Sandin S, Sandor P, Spalletta G, Stein DJ, Stewart SE, Storch EA, Stranger BE, Turiel M, Werge T, Andreassen OA, Børglum AD, Walitza S, Hveem K, Hansen BK, Rück C, Martin NG, Milani L, Mors O, Reichborn-Kjennerud T, Ribasés M, Kvale G, Mataix-Cols D, Domschke K, Grünblatt E, Wagner M, Zwart JA, Breen G, Nestadt G, Kaprio J, Arnold PD, Grice DE, Knowles JA, Ask H, Verweij KJ, Davis LK, Smit DJ, Crowley JJ, Scharf JM, Stein MB, Gelernter J, Mathews CA, Derks EM, Mattheisen M. Nat Genet. 2025 Jun; 2025 May 13. PMID: 40360802.", + "Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. Strom NI, Gerring ZF, Galimberti M, Yu D, Halvorsen MW, Abdellaoui A, Rodriguez-Fontenla C, Sealock JM, Bigdeli T, Coleman JR, Mahjani B, Thorp JG, Bey K, Burton CL, Luykx JJ, Zai G, Alemany S, Andre C, Askland KD, Bäckmann J, Banaj N, Barlassina C, Nissen JB, Bienvenu OJ, Black D, Bloch MH, Børte S, Bosch R, Breen M, Brennan BP, Brentani H, Buxbaum JD, Bybjerg-Grauholm J, Byrne EM, Cabana-Dominguez J, Camarena B, Camarena A, Cappi C, Carracedo A, Casas M, Cavallini MC, Ciullo V, Cook EH, Crosby J, Cullen BA, De Schipper EJ, Delorme R, Djurovic S, Elias JA, Estivill X, Falkenstein MJ, Fundin BT, Garner L, Gironda C, Goes FS, Grados MA, Grove J, Guo W, Haavik J, Hagen K, Harrington K, Havdahl A, Höffler KD, Hounie AG, Hucks D, Hultman C, Janecka M, Jenike E, Karlsson EK, Kelley K, Klawohn J, Krasnow JE, Krebs K, Lange C, Lanzagorta N, Levey D, Lindblad-Toh K, Macciardi F, Maher B, Mathes B, McArthur E, McGregor N, McLaughlin NC, Meier S, Miguel EC, Mulhern M, Nestadt PS, Nurmi EL, O'Connell KS, Osiecki L, Ousdal OT, Palviainen T, Pedersen NL, Piras F, Piras F, Potluri S, Rabionet R, Ramirez A, Rauch S, Reichenberg A, Riddle MA, Ripke S, Rosário MC, Sampaio AS, Schiele MA, Skogholt AH, Sloofman LG, Smit J, Soler Artigas M, Thomas LF, Tifft E, Vallada H, van Kirk N, Veenstra-VanderWeele J, Vulink NN, Walker CP, Wang Y, Wendland JR, Winsvold BS, Yao Y, Zhou H, Agrawal A, Alonso P, Berberich G, Bucholz KK, Bulik CM, Cath D, Denys D, Eapen V, Edenberg H, Falkai P, Fernandez TV, Fyer AJ, Gaziano JM, Geller DA, Grabe HJ, Greenberg BD, Hanna GL, Hickie IB, Hougaard DM, Kathmann N, Kennedy J, Lai D, Landén M, Le Hellard S, Leboyer M, Lochner C, McCracken JT, Medland SE, Mortensen PB, Neale BM, Nicolini H, Nordentoft M, Pato M, Pato C, Pauls DL, Piacentini J, Pittenger C, Posthuma D, Ramos-Quiroga JA, Rasmussen SA, Richter MA, Rosenberg DR, Ruhrmann S, Samuels JF, Sandin S, Sandor P, Spalletta G, Stein DJ, Stewart SE, Storch EA, Stranger BE, Turiel M, Werge T, Andreassen OA, Børglum AD, Walitza S, Hveem K, Hansen BK, Rück C, Martin NG, Milani L, Mors O, Reichborn-Kjennerud T, Ribasés M, Kvale G, Mataix-Cols D, Domschke K, Grünblatt E, Wagner M, Zwart JA, Breen G, Nestadt G, Kaprio J, Arnold PD, Grice DE, Knowles JA, Ask H, Verweij KJ, Davis LK, Smit DJ, Crowley JJ, Scharf JM, Stein MB, Gelernter J, Mathews CA, Derks EM, Mattheisen M. medRxiv. 2025 Apr 8; 2025 Apr 8. PMID: 38712091.", + "Characterizing Rare DNA Copy-Number Variants in Pediatric Obsessive-Compulsive Disorder. Abdallah SB, Olfson E, Cappi C, Greenspun S, Zai G, Rosário MC, Willsey AJ, Shavitt RG, Miguel EC, Kennedy JL, Richter MA, Fernandez TV. J Am Acad Child Adolesc Psychiatry. 2025 Mar 21; 2025 Mar 21. PMID: 40122455.", + "Genetics of Tourette Syndrome. Fernandez TV. Psychiatr Clin North Am. 2025 Mar; 2024 Oct 2. PMID: 39880506.", + "Rare Variant Analyses in Ancestrally Diverse Cohorts Reveal Novel ADHD Risk Genes. Jung S, Caballero M, Olfson E, Newcorn JH, Fernandez TV, Mahjani B. medRxiv. 2025 Jan 17; 2025 Jan 17. PMID: 39867378.", + "The genetics of trichotillomania and excoriation disorder: A systematic review. Reid M, Lin A, Farhat LC, Fernandez TV, Olfson E. Compr Psychiatry. 2024 Aug; 2024 May 31. PMID: 38833896.", + "Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes. Olfson E, Farhat LC, Liu W, Vitulano LA, Zai G, Lima MO, Parent J, Polanczyk GV, Cappi C, Kennedy JL, Fernandez TV. Nat Commun. 2024 Jul 12; 2024 Jul 12. PMID: 38997333.", + "Intense Imagery Movements May Lead to Maladaptive Daydreaming: A Case Series and Literature Review. Hedderly T, Eccles C, Malik O, Abdulsatar F, Mitchell C, Owen T, Soffer-Dudek N, Grose C, Fernandez TV, Robinson S, Somer E. Mov Disord Clin Pract. 2024 Jun; 2024 Mar 27. PMID: 38533626.", + "Clinical characteristics of probands with obsessive-compulsive disorder from simplex and multiplex families. Lima MO, Saraiva LC, Ramos VR, Oliveira MC, Costa DLC, Fernandez TV, Crowley JJ, Storch EA, Shavitt RG, Miguel EC, Cappi C. Psychiatry Res. 2024 Jan; 2023 Nov 30. PMID: 38113811.", + "Rare X-linked variants carry predominantly male risk in autism, Tourette syndrome, and ADHD. Wang S, Wang B, Drury V, Drake S, Sun N, Alkhairo H, Arbelaez J, Duhn C, Bal VH, Langley K, Martin J, Hoekstra PJ, Dietrich A, Xing J, Heiman GA, Tischfield JA, Fernandez TV, Owen MJ, O'Donovan MC, Thapar A, State MW, Willsey AJ. Nat Commun. 2023 Dec 6; 2023 Dec 6. PMID: 38057346.", + "Protocol description for a randomized controlled trial of fMRI neurofeedback for tics in adolescents with Tourette Syndrome. Awasthi J, Harris-Starling C, Kalvin C, Pittman B, Park H, Bloch M, Fernandez TV, Sukhodolsky DG, Hampson M. Psychiatry Res Neuroimaging. 2023 Dec; 2023 Jul 22. PMID: 37673711.", + "Primary complex motor stereotypies are associated with de novo damaging DNA coding mutations that identify KDM5B as a risk gene. Fernandez TV, Williams ZP, Kline T, Rajendran S, Augustine F, Wright N, Sullivan CAW, Olfson E, Abdallah SB, Liu W, Hoffman EJ, Gupta AR, Singer HS. PLoS One. 2023; 2023 Oct 3. PMID: 37788244.", + "Efficient reconstruction of cell lineage trees for cell ancestry and cancer. Jang Y, Fasching L, Bae T, Tomasini L, Schreiner J, Szekely A, Fernandez TV, Leckman JF, Vaccarino FM, Abyzov A. Nucleic Acids Res. 2023 Jun 9. PMID: 37026484.", + "Characteristics of trichotillomania and excoriation disorder across the lifespan. Lin A, Farhat LC, Flores JM, Levine JLS, Fernandez TV, Bloch MH, Olfson E. Psychiatry Res. 2023 Apr; 2023 Feb 21. PMID: 36842397.", + "Whole-exome DNA sequencing in childhood anxiety disorders identifies rare de novo damaging coding variants. Olfson E, Lebowitz ER, Hommel G, Pashankar N, Silverman WK, Fernandez TV. Depress Anxiety. 2022 Jun; 2022 Mar 21. PMID: 35312124.", + "Investigation of gene-environment interactions in relation to tic severity. Abdulkadir M, Yu D, Osiecki L, King RA, Fernandez TV, Brown LW, Cheon KA, Coffey BJ, Garcia-Delgar B, Gilbert DL, Grice DE, Hagstrøm J, Hedderly T, Heyman I, Hong HJ, Huyser C, Ibanez-Gomez L, Kim YK, Kim YS, Koh YJ, Kook S, Kuperman S, Leventhal B, Madruga-Garrido M, Maras A, Mir P, Morer A, Münchau A, Plessen KJ, Roessner V, Shin EY, Song DH, Song J, Visscher F, Zinner SH, Mathews CA, Scharf JM, Tischfield JA, Heiman GA, Dietrich A, Hoekstra PJ. J Neural Transm (Vienna). 2021 Nov; 2021 Aug 13. PMID: 34389898.", + "Whole-exome sequencing identifies genes associated with Tourette's disorder in multiplex families. Cao X, Zhang Y, Abdulkadir M, Deng L, Fernandez TV, Garcia-Delgar B, Hagstrøm J, Hoekstra PJ, King RA, Koesterich J, Kuperman S, Morer A, Nasello C, Plessen KJ, Thackray JK, Zhou L, Dietrich A, Tischfield JA, Heiman GA, Xing J. Mol Psychiatry. 2021 Nov; 2021 Apr 9. PMID: 33837273.", + "Leveraging aggression risk gene expression in the developing and adult human brain to guide future precision interventions. Kim A, Rader SL, Fernandez TV, Vandekar SN, Lewis AS. Mol Psychiatry. 2021 Jul; 2020 Oct 12. PMID: 33046832.", + "Early developmental asymmetries in cell lineage trees in living individuals. Fasching L, Jang Y, Tomasi S, Schreiner J, Tomasini L, Brady MV, Bae T, Sarangi V, Vasmatzis N, Wang Y, Szekely A, Fernandez TV, Leckman JF, Abyzov A, Vaccarino FM. Science. 2021 Mar 19. PMID: 33737484.", + "Synaptic processes and immune-related pathways implicated in Tourette syndrome. Tsetsos F, Yu D, Sul JH, Huang AY, Illmann C, Osiecki L, Darrow SM, Hirschtritt ME, Greenberg E, Muller-Vahl KR, Stuhrmann M, Dion Y, Rouleau GA, Aschauer H, Stamenkovic M, Schlögelhofer M, Sandor P, Barr CL, Grados MA, Singer HS, Nöthen MM, Hebebrand J, Hinney A, King RA, Fernandez TV, Barta C, Tarnok Z, Nagy P, Depienne C, Worbe Y, Hartmann A, Budman CL, Rizzo R, Lyon GJ, McMahon WM, Batterson JR, Cath DC, Malaty IA, Okun MS, Berlin C, Woods DW, Lee PC, Jankovic J, Robertson MM, Gilbert DL, Brown LW, Coffey BJ, Dietrich A, Hoekstra PJ, Kuperman S, Zinner SH, Wagner M, Knowles JA, Jeremy Willsey A, Tischfield JA, Heiman GA, Cox NJ, Freimer NB, Neale BM, Davis LK, Coppola G, Mathews CA, Scharf JM, Paschou P, Barr CL, Batterson JR, Berlin C, Budman CL, Cath DC, Coppola G, Cox NJ, Darrow S, Davis LK, Dion Y, Freimer NB, Grados MA, Greenberg E, Hirschtritt ME, Huang AY, Illmann C, King RA, Kurlan R, Leckman JF, Lyon GJ, Malaty IA, Mathews CA, McMahon WM, Neale BM, Okun MS, Osiecki L, Robertson MM, Rouleau GA, Sandor P, Scharf JM, Singer HS, Smit JH, Sul JH, Yu D, Aschauer HAH, Barta C, Budman CL, Cath DC, Depienne C, Hartmann A, Hebebrand J, Konstantinidis A, Mathews CA, Müller-Vahl K, Nagy P, Nöthen MM, Paschou P, Rizzo R, Rouleau GA, Sandor P, Scharf JM, Schlögelhofer M, Stamenkovic M, Stuhrmann M, Tsetsos F, Tarnok Z, Wolanczyk T, Worbe Y, Brown L, Cheon KA, Coffey BJ, Dietrich A, Fernandez TV, Garcia-Delgar B, Gilbert D, Grice DE, Hagstrøm J, Hedderly T, Heiman GA, Heyman I, Hoekstra PJ, Huyser C, Kim YK, Kim YS, King RA, Koh YJ, Kook S, Kuperman S, Leventhal BL, Madruga-Garrido M, Mir P, Morer A, Münchau A, Plessen KJ, Roessner V, Shin EY, Song DH, Song J, Tischfield JA, Willsey AJ, Zinner S, Aschauer H, Barr CL, Barta C, Batterson JR, Berlin C, Brown L, Budman CL, Cath DC, Coffey BJ, Coppola G, Cox NJ, Darrow S, Davis LK, Depienne C, Dietrich A, Dion Y, Fernandez T, Freimer NB, Gilbert D, Grados MA, Greenberg E, Hartmann A, Hebebrand J, Heiman G, Hirschtritt ME, Hoekstra P, Huang AY, Illmann C, Jankovic J, King RA, Kuperman S, Lee PC, Lyon GJ, Malaty IA, Mathews CA, McMahon WM, Müller-Vahl K, Nagy P, Neale BM, Nöthen MM, Okun MS, Osiecki L, Paschou P, Rizzo R, Robertson MM, Rouleau GA, Sandor P, Scharf JM, Schlögelhofer M, Singer HS, Stamenkovic M, Stuhrmann M, Sul JH, Tarnok Z, Tischfield J, Tsetsos F, Willsey AJ, Woods D, Worbe Y, Yu D, Zinner S. Transl Psychiatry. 2021 Jan 18; 2021 Jan 18. PMID: 33462189.", + "Empiric Recurrence Risk Estimates for Chronic Tic Disorders: Implications for Genetic Counseling. Heiman GA, Rispoli J, Seymour C, Leckman JF, King RA, Fernandez TV. Front Neurol. 2020; 2020 Aug 11. PMID: 32849224.", + "De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism. Cappi C, Oliphant ME, Péter Z, Zai G, Conceição do Rosário M, Sullivan CAW, Gupta AR, Hoffman EJ, Virdee M, Olfson E, Abdallah SB, Willsey AJ, Shavitt RG, Miguel EC, Kennedy JL, Richter MA, Fernandez TV. Biol Psychiatry. 2020 Jun 15; 2019 Oct 16. PMID: 31771860.", + "Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies. 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J Am Acad Child Adolesc Psychiatry. 2014 Aug; 2014 Jun 24. PMID: 25062598.", + "Rare deleterious mutations of the gene EFR3A in autism spectrum disorders. Gupta AR, Pirruccello M, Cheng F, Kang HJ, Fernandez TV, Baskin JM, Choi M, Liu L, Ercan-Sencicek AG, Murdoch JD, Klei L, Neale BM, Franjic D, Daly MJ, Lifton RP, De Camilli P, Zhao H, Sestan N, State MW. Mol Autism. 2014; 2014 Apr 29. PMID: 24860643.", + "Gene variants associated with antisocial behaviour: a latent variable approach. Bentley MJ, Lin H, Fernandez TV, Lee M, Yrigollen CM, Pakstis AJ, Katsovich L, Olds DL, Grigorenko EL, Leckman JF. J Child Psychol Psychiatry. 2013 Oct; 2013 Jul 3. PMID: 23822756.", + "Data blitz debuts at the AACAP annual meeting. Vanderwal T, Fernandez T. J Child Adolesc Psychopharmacol. 2013 Jun. PMID: 23782124.", + "Transcranial magnetic stimulation of Wernicke's and Right homologous sites to curtail \"voices\": a randomized trial. Hoffman RE, Wu K, Pittman B, Cahill JD, Hawkins KA, Fernandez T, Hannestad J. Biol Psychiatry. 2013 May 15; 2013 Feb 26. PMID: 23485015.", + "Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism. Fernandez TV, Sanders SJ, Yurkiewicz IR, Ercan-Sencicek AG, Kim YS, Fishman DO, Raubeson MJ, Song Y, Yasuno K, Ho WS, Bilguvar K, Glessner J, Chu SH, Leckman JF, King RA, Gilbert DL, Heiman GA, Tischfield JA, Hoekstra PJ, Devlin B, Hakonarson H, Mane SM, Günel M, State MW. Biol Psychiatry. 2012 Mar 1; 2011 Dec 14. PMID: 22169095.", + "Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Sanders SJ, Ercan-Sencicek AG, Hus V, Luo R, Murtha MT, Moreno-De-Luca D, Chu SH, Moreau MP, Gupta AR, Thomson SA, Mason CE, Bilguvar K, Celestino-Soper PB, Choi M, Crawford EL, Davis L, Wright NR, Dhodapkar RM, DiCola M, DiLullo NM, Fernandez TV, Fielding-Singh V, Fishman DO, Frahm S, Garagaloyan R, Goh GS, Kammela S, Klei L, Lowe JK, Lund SC, McGrew AD, Meyer KA, Moffat WJ, Murdoch JD, O'Roak BJ, Ober GT, Pottenger RS, Raubeson MJ, Song Y, Wang Q, Yaspan BL, Yu TW, Yurkiewicz IR, Beaudet AL, Cantor RM, Curland M, Grice DE, Günel M, Lifton RP, Mane SM, Martin DM, Shaw CA, Sheldon M, Tischfield JA, Walsh CA, Morrow EM, Ledbetter DH, Fombonne E, Lord C, Martin CL, Brooks AI, Sutcliffe JS, Cook EH Jr, Geschwind D, Roeder K, Devlin B, State MW. Neuron. 2011 Jun 9. PMID: 21658581.", + "Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia. Hoffman RE, Fernandez T, Pittman B, Hampson M. Biol Psychiatry. 2011 Mar 1; 2010 Dec 8. PMID: 21145042.", + "L-histidine decarboxylase and Tourette's syndrome. Ercan-Sencicek AG, Stillman AA, Ghosh AK, Bilguvar K, O'Roak BJ, Mason CE, Abbott T, Gupta A, King RA, Pauls DL, Tischfield JA, Heiman GA, Singer HS, Gilbert DL, Hoekstra PJ, Morgan TM, Loring E, Yasuno K, Fernandez T, Sanders S, Louvi A, Cho JH, Mane S, Colangelo CM, Biederer T, Lifton RP, Gunel M, State MW. N Engl J Med. 2010 May 20; 2010 May 5. PMID: 20445167.", + "Molecular characterization of a patient with 3p deletion syndrome and a review of the literature. Fernandez TV, García-González IJ, Mason CE, Hernández-Zaragoza G, Ledezma-Rodríguez VC, Anguiano-Alvarez VM, E'Vega R, Gutiérrez-Angulo M, Maya ML, García-Bejarano HE, González-Cruz M, Barrios S, Atorga R, López-Cardona MG, Armendariz-Borunda J, State MW, Dávalos NO. Am J Med Genet A. 2008 Nov 1. PMID: 18837054.", + "Disruption of Contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome. Fernandez T, Morgan T, Davis N, Klin A, Morris A, Farhi A, Lifton RP, State MW. Am J Hum Genet. 2008 Jun. PMID: 18551756.", + "Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome. Fernandez T, Morgan T, Davis N, Klin A, Morris A, Farhi A, Lifton RP, State MW. Am J Hum Genet. 2004 Jun; 2004 Apr 21. PMID: 15106122.", + "Premorbid speech and language impairments in childhood-onset schizophrenia: association with risk factors. Nicolson R, Lenane M, Singaracharlu S, Malaspina D, Giedd JN, Hamburger SD, Gochman P, Bedwell J, Thaker GK, Fernandez T, Wudarsky M, Hommer DW, Rapoport JL. Am J Psychiatry. 2000 May. PMID: 10784474.", + "Lessons from childhood-onset schizophrenia. Nicolson R, Lenane M, Hamburger SD, Fernandez T, Bedwell J, Rapoport JL. Brain Res Brain Res Rev. 2000 Mar. PMID: 10719143.", + "Obstetrical complications and childhood-onset schizophrenia. Nicolson R, Malaspina D, Giedd JN, Hamburger S, Lenane M, Bedwell J, Fernandez T, Berman A, Susser E, Rapoport JL. Am J Psychiatry. 1999 Oct. PMID: 10518182.", + "Clinical and neurobiological correlates of cytogenetic abnormalities in childhood-onset schizophrenia. Nicolson R, Giedd JN, Lenane M, Hamburger S, Singaracharlu S, Bedwell J, Fernandez T, Thaker GK, Malaspina D, Rapoport JL. Am J Psychiatry. 1999 Oct. PMID: 10518169.", + "Childhood-onset schizophrenia: progressive brain changes during adolescence. Giedd JN, Jeffries NO, Blumenthal J, Castellanos FX, Vaituzis AC, Fernandez T, Hamburger SD, Liu H, Nelson J, Bedwell J, Tran L, Lenane M, Nicolson R, Rapoport JL. Biol Psychiatry. 1999 Oct 1. PMID: 10509172.", + "Progressive cortical change during adolescence in childhood-onset schizophrenia. A longitudinal magnetic resonance imaging study. Rapoport JL, Giedd JN, Blumenthal J, Hamburger S, Jeffries N, Fernandez T, Nicolson R, Bedwell J, Lenane M, Zijdenbos A, Paus T, Evans A. Arch Gen Psychiatry. 1999 Jul. PMID: 10401513.", + "Apolipoprotein E alleles in childhood-onset schizophrenia. Fernandez T, Yan WL, Hamburger S, Rapoport JL, Saunders AM, Schapiro M, Ginns EI, Sidransky E. Am J Med Genet. 1999 Apr 16. PMID: 10206244.", + "Functional differentiation along the anterior-posterior axis of the hippocampus in monkeys. Colombo M, Fernandez T, Nakamura K, Gross CG. J Neurophysiol. 1998 Aug. PMID: 9705488.", + "Brief report: association of sex chromosome anomalies with childhood-onset psychotic disorders. Kumra S, Wiggs E, Krasnewich D, Meck J, Smith AC, Bedwell J, Fernandez T, Jacobsen LK, Lenane M, Rapoport JL. J Am Acad Child Adolesc Psychiatry. 1998 Mar. PMID: 9519634.", + "Sterling Hall of Medicine 333 Cedar Street New Haven, CT 06520-8023 Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Fikrig Lab", + "lab_url": "https://medicine.yale.edu/lab/fikrig/", + "research_bio": "INFORMATION FOR The Fikrig laboratory focuses on arthropod-borne infectious diseases. We examine the relationships between pathogens, the vectors that carry them, and the hosts they infect. This information is used to (a) develop new ways to disrupt these interactions, (b) interfere with pathogen transmission and (c) generate new types of vaccines. Borrelia, Anaplasma, Flaviviruses and Plasmodium are the microbes that we study, and ticks and mosquitoes are the main arthropods that we target. Our laboratory is interested in how pathogens use arthropod products to facilitate infection of the mammalian host. For example, as Borrelia burgdorferi, the Lyme disease agent, migrate from ticks to humans, the spirochetes influence the expression of tick salivary gland genes. B. burgdorferi then uses some of these tick proteins, directly or indirectly, to evade the mammalian host responses. These discoveries help support the paradigm that microbes use arthropod molecules to successfully infect the vertebrate host: a triangular interaction at the ephemeral pathogen-vector-host interface that occurs while an arthropod is taking a blood meal. We are expanding this concept to other tick-borne infectious agents, including Anaplasma phagocytophilum (the agent of human granulocytic anaplasmosis) and Powassan virus (a flavivirus), and mosquito-borne pathogens such as West Nile, Zika and Dengue viruses (all flaviviruses) and Plasmodium falciparum (which causes malaria). We are developing techniques to identify the entire panel of vector genes that are induced or repressed by pathogens, and assays to delineate the complete profile of arthropod proteins that microbes adhere to, or otherwise interact with. We are also assessing the immune response to these pathogens at the bite site, and examining how the vectors and pathogens influence the immune response. Understanding these interactions may lead to new ways to interrupt the life cycle of arthropod-borne pathogens and new vaccine strategies against these diseases. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Finberg Lab", + "lab_url": "https://medicine.yale.edu/lab/finberg/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Flavell Lab", + "lab_url": "https://medicine.yale.edu/lab/flavell/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Foxman Lab", + "lab_url": "https://medicine.yale.edu/lab/foxman/", + "research_bio": "INFORMATION FOR Copy Link The Foxman lab investigates the natural defense mechanisms that protect the respiratory tract from infection and injury. This includes studying immune responses of tissues that are not traditionally considered part of the immune system, such as the cells that form the lining of the nasal passages and lung airways. Our goal is to identify fundamental mechanisms of innate immunity and to use these discoveries to find new ways to detect, prevent, and treat viral infections and chronic lung diseases. Copy Link Children had less severe illness from COVID-19 than expected, and initial research on this phenomenon showed that children have heightened non-specific (“innate”) nasal immune responses compared to adults. While standard diagnostic tests for viruses (e.g. PCR) are virus-specific, but the body's innate immune sensors can diagnose broad categories of infection with no prior knowledge of the pathogen. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "FRESH Collaborative – Family-centered Research in Equity, Safety and Healing", + "lab_url": "https://medicine.yale.edu/lab/fresh/", + "research_bio": "INFORMATION FOR We are a collaborative from the Yale School of Medicine’s Child Abuse Programs, Section of Pediatric Emergency Medicine, and local domestic violence organizations dedicated to advocating for the safety of children and their families. Our goals are to improve the recognition and reporting of child abuse and neglect in acute care settings and develop family-centered interventions for household violence. We work closely with services throughout the greater New Haven community, including the Connecticut Coalition Against Domestic Violence (CCADV), The Umbrella Center for Domestic Violence Services, Connecticut Department of Children and Families, and community representatives. Copy Link Since 1967, the Child Abuse Programs at Yale New Haven Children’s Hospital have provided care to injured children in the hospital. In collaboration with the Department of Pediatrics at Yale School of Medicine and the Department of Social Work at Yale New Haven Hospital, our services have expanded over the years to include the care of sexually abused children, state-wide consultation services, a treatment program, educational programs for new parents, and home visiting. Copy Link Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/fresh/publications/", + "publications": [ + "Yale School of Medicine /", + "Pediatrics /", + "Pediatric Emergency Medicine /", + "Research", + "Publications", + "Lab Members", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Publications", + "Lab Members", + "", + "", + "", + "", + "", + "", + "An Electronic Health Record-Integrated Clinical Pathway Improves Care of Sexual Assault Survivors. Yang DH, Sherak R, Chin M, Pagano E, Tyrrell JD, Sullivan T, Henderson R, Jubanyik K, Dodington J, Rhodes D, Gawel M, Sangal RB. Acad Emerg Med. 2025 Oct 28; 2025 Oct 28. PMID: 41147845.", + "Safer Child Protective Services Reporting-The BEST Timeout Model. Metz JB, Roy AD, Asnes AG. JAMA Pediatr. 2025 Oct 1. PMID: 40853555.", + "A Multiphase Quality Improvement Project to Increase Relative Value Unit Generation Through Documentation Practices in a Pediatric Emergency Department. Fairchild VC, Powers E, Siew L, Mistry R, Tiyyagura G, Goldman MP. Pediatr Emerg Care. 2025 Oct 1; 2025 Jul 15. PMID: 40660611.", + "\"Just Take the Two Minutes\". Shum M. Pediatr Crit Care Med. 2025 Jul 1; 2025 May 14. PMID: 40366213.", + "THC Ingestions and Child Protective Services: Guidelines for Practitioners. Raz M, Gupta-Kagan J, Asnes AG. J Addict Med. 2025 Jul-Aug 01; 2025 Jan 3. PMID: 39749930.", + "The Perspective of Adolescent Victims of Violence on Resilience and Social Connectedness. Raman U, Atiencia-Arizaga M, Paredes L, McNamara M, Gawel M, Kazmir S, Dodington J. J Interpers Violence. 2025 Jun 19; 2025 Jun 19. PMID: 40537454.", + "Impact of Intimate Partner Violence on Children. Doswell A, Kazmir S, Segal R, Tiyyagura G. Pediatr Clin North Am. 2025 Jun; 2025 Feb 5. PMID: 40335175.", + "\"No One Really Prepares You\": Lived Experiences of Women Division Chiefs in Academic Medicine. Loyal J, Beagan R, Dias M, Asnes A. J Womens Health (Larchmt). 2025 Mar; 2024 Dec 23. PMID: 39714989.", + "Developing CLOUT: A Longitudinal, Cross-Program Chief Resident Curriculum to Increase Psychological Safety in the Clinical Learning Environment. Dunne D, Asnes A, Berg D, Chen A, Dewey J, Gupta S, Fernandes CS, Huot SJ. Acad Med. 2024 Dec 1; 2024 Sep 4. PMID: 39601612.", + "Child abuse, neglect, and exploitation of young people. Asnes AG, Tiyyagura G. BMJ. 2024 Nov 11; 2024 Nov 11. PMID: 39528262.", + "Acceptability and feasibility of trauma- and violence-informed care for intimate partner violence. Tiyyagura G, Leventhal JM, Schaeffer P, Gawel M, Crawley D, Frechette A, Reames S, Carlson C, Sullivan T, Asnes A. Child Abuse Negl. 2024 Nov; 2024 Sep 26. PMID: 39332141.", + "Should I Call Child Protection?-Guidelines for Clinicians. Raz M, Gupta-Kagan J, Asnes AG. JAMA Pediatr. 2024 Nov 1. PMID: 39283630.", + "The Role of International Classification of Diseases 10 Codes in Intimate Partner Violence Surveillance: Examining the Sensitivity and Specificity of Current Practice. Shum M, Robertson D, Ryus C, Tiyyagura G. Ann Emerg Med. 2024 Aug; 2024 Apr 24. PMID: 38661621.", + "Disclosure Is an Essential Component of Ethical Practice: \"I Am the Child Abuse Pediatrician\". Raz M, Gupta-Kagan J, Asnes AG. JAMA Pediatr. 2024 Jul 1. PMID: 38739410.", + "Development and Evaluation of a Community Advisory Board for Family Violence. Tiyyagura G, Leventhal JM, Schaeffer P, Frechette A, Crawley D, Sommer E, Lopes C, Serrechia P, Asnes AG. Violence Vict. 2024 Jun 1. PMID: 38955471.", + "Correction: Developing and Testing the Usability of a Novel Child Abuse Clinical Decision Support System: Mixed Methods Study. Thomas A, Asnes A, Libby K, Hsiao A, Tiyyagura G. J Med Internet Res. 2024 May 27; 2024 May 27. PMID: 38801770.", + "Resilience Curriculum Improves Skills of Pediatric Fellows in Delivery of Difficult News. Murtha TD, Hafler J, Taylor EP, Tala J, Asnes A, Massaro S, Kandil S. R I Med J (2013). 2024 May 2; 2024 May 2. PMID: 38687270.", + "No Science Supports the Diagnostic Methods for Abusive Head Trauma-Reply. Leventhal JM, Asnes AG, Edwards GA. JAMA Pediatr. 2024 May 1. PMID: 38436949.", + "Is it Smoke and Mirrors? Detection of Inferior Vena Cava Thrombus by Focused Cardiac Ultrasound. Soma G, DeGuardi J, Iqbal AU, Leviter J, Riera A. Pediatr Emerg Care. 2024 Apr 1; 2024 Jan 15. PMID: 38227793.", + "A pilot clinical trial of the Screening and Tool for Awareness and Relief of Trauma for survivors of gun violence. O'Neill KM, Schenck C, Vega P, Gawel M, Dodington J. J Trauma Acute Care Surg. 2024 Apr 1; 2023 Aug 21. PMID: 37602906.", + "Developing and Testing the Usability of a Novel Child Abuse Clinical Decision Support System: Mixed Methods Study. Thomas A, Asnes A, Libby K, Hsiao A, Tiyyagura G. J Med Internet Res. 2024 Mar 29; 2024 Mar 29. PMID: 38551639.", + "\"They're scared that somebody's gonna judge them\": Female African American youth in foster care's perspectives on sexual and reproductive health communication with caregivers. Ross C, Smith JG, Gawel M, Walters TL, Song Y, Cong X, Shook NJ. J Pediatr Nurs. 2024 Mar-Apr; 2023 Dec 12. PMID: 38091927.", + "Selection and Recruitment Strategies among Competitive Pediatric Training Programs and the Impact of Diversity. Tiyyagura G, Weiss J, Goldman MP, Crawley DM, Langhan ML. Acad Pediatr. 2024 Mar; 2023 Sep 23. PMID: 37748536.", + "The Role of Advanced Practice Providers in Pediatric Emergency Care Across Nine Emergency Departments. Iqbal AU, Whitfill T, Tiyyagura G, Auerbach M. Pediatr Emerg Care. 2024 Feb 1. PMID: 38286004.", + "Identifying Gender and Racial Bias in Pediatric Fellowship Letters of Recommendation: Do Word Choices Influence Interview Decisions? Boolchandani H, Chen L, Elder RW, Osborn R, Phatak UP, Puthenpura V, Sheares BJ, Tiyyagura G, Amster L, Lee S, Langhan ML. J Pediatr. 2024 Feb; 2023 Nov 22. PMID: 37995931.", + "Increasing the use of anxiolysis and analgesia for paediatric procedures in a community emergency department network: a quality improvement initiative. Nocera Kelley M, Lynders W, Pelletier E, Petrucelli M, Emerson B, Tiyyagura GK, Goldman MP. Emerg Med J. 2024 Jan 22; 2024 Jan 22. PMID: 38050053.", + "Natural Language Processing - A Surveillance Stepping Stone to Identify Child Abuse. Shum M, Hsiao A, Teng W, Asnes A, Amrhein J, Tiyyagura G. Acad Pediatr. 2024 Jan-Feb; 2023 Aug 29. PMID: 37652162.", + "How Antiscience Creates Confusion About the Diagnosis of Abusive Head Trauma. Leventhal JM, Asnes AG, Otterman GJ. JAMA Pediatr. 2023 Dec 1. PMID: 37902740.", + "Hospital Admissions for Abusive Head Trauma Before and During the COVID-19 Pandemic. Maassel NL, Graetz E, Schneider EB, Asnes AG, Solomon DG, Leventhal JM. JAMA Pediatr. 2023 Dec 1. PMID: 37870839.", + "Using Child Abuse Specialists to Reduce Unnecessary Child Protective Services Reports and Investigations. Raz M, Gupta-Kagan J, Asnes AG. JAMA Pediatr. 2023 Dec 1. PMID: 37812436.", + "Implementation of an emerging hospital-based violence intervention program: a multimethod study. Schenck CS, Dodington J, Paredes L, Gawel M, Nedd A, Vega P, O'Neill KM. Trauma Surg Acute Care Open. 2023; 2023 Nov 20. PMID: 38020854.", + "Words Used in Letters of Recommendation for Pediatric Residency Applicants: Demographic Differences and Impact on Interviews. Boolchandani H, Osborn R, Tiyyagura G, Sheares B, Chen L, Phatak UP, Puthenpura V, Elder RW, Lee S, Amster L, Langhan ML. Acad Pediatr. 2023 Nov-Dec; 2023 Mar 6. PMID: 36889506.", + "A quality improvement approach to integrating social determinants of health objectives into pediatric simulation. Feick M, Iqbal AU, Boolchandani H, Kandil S, Johnston L, Soma G, Cordone A, Auerbach M, Tiyyagura G. AEM Educ Train. 2023 Oct; 2023 Oct 2. PMID: 37791136.", + "Frequency of injuries in a voluntary program evaluating young children exposed to intimate partner violence. Tiyyagura G, Leventhal JM, Crawley D, Asnes AG. Child Abuse Negl. 2023 Oct; 2023 Aug 2. PMID: 37541095.", + "Experiences with Racism Among Asian American Medical Students. Yang DH, Justen M, Lee D, Kim H, Boatright D, Desai M, Tiyyagura G. JAMA Netw Open. 2023 Sep 5; 2023 Sep 5. PMID: 37695582.", + "Evaluation of Children after Caregiver Intimate Partner Violence: A Qualitative Study of Barriers, Facilitators, and Trauma- and Violence-Informed Care. Tiyyagura G, Clayton N, Schaeffer P, Gawel M, Leventhal JM, Hammel K, Jubanyik K, Crawley D, Frechette A, Lindberg DM, Sullivan T, Asnes A. J Pediatr. 2023 Sep; 2023 May 26. PMID: 37244576.", + "Factors Associated With Improved Pediatric Resuscitative Care in General Emergency Departments. Auerbach MA, Whitfill T, Montgomery E, Leung J, Kessler D, Gross IT, Walsh BM, Fiedor Hamilton M, Gawel M, Kant S, Janofsky S, Brown LL, Walls TA, Alletag M, Sessa A, Arteaga GM, Keilman A, Van Ittersum W, Rutman MS, Zaveri P, Good G, Schoen JC, Lavoie M, Mannenbach M, Bigham L, Dudas RA, Rutledge C, Okada PJ, Moegling M, Anderson I, Tay KY, Scherzer DJ, Vora S, Gaither S, Fenster D, Jones D, Aebersold M, Chatfield J, Knight L, Berg M, Makharashvili A, Katznelson J, Mathias E, Lutfi R, Abu-Sultaneh S, Burns B, Padlipsky P, Lee J, Butler L, Alander S, Thomas A, Bhatnagar A, Jafri FN, Crellin J, Abulebda K. Pediatrics. 2023 Aug 1. PMID: 37416979.", + "Data omissions and the diagnosis of abusive head trauma. Leventhal JM, Edwards GA, Asnes AG, Otterman GJ. Acta Paediatr. 2023 Aug; 2022 Mar 29. PMID: 35316546.", + "Trauma-informed and family-centered paediatric resuscitation: Defining domains and practices. Kassam-Adams N, Butler L, Price J, Gawel M, Graham L, Myers S, Auerbach M. Resusc Plus. 2023 Jun; 2023 Mar 21. PMID: 37007186.", + "Protecting Survivors of Intimate Partner Violence Under the Cures Act. Shum M, Ryus C, Chen P, Powers E, Jubanyik K, Tiyyagura G. Ann Emerg Med. 2023 Jun; 2023 Mar 3. PMID: 36870889.", + "Emergency department visits in Connecticut for survivors of sexual assault before and during the COVID-19 pandemic. Yang D, Cordone A, Sun WW, Gawel M, Sangal RB, Dodington J. Am J Emerg Med. 2023 May; 2023 Feb 14. PMID: 36842427.", + "Intimate partner violence screening during COVID-19. Hoffman RM, Ryus C, Tiyyagura G, Jubanyik K. PLoS One. 2023; 2023 Apr 24. PMID: 37093791.", + "Anti-Black racism in clinical supervision: asynchronous simulated encounters facilitate reflective practice. Calhoun AJ, Martin A, Adigun A, Alleyne SD, Aneni K, Thompson-Felix T, Asnes A, de Carvalho-Filho MA, Benoit L, Genao I. MedEdPublish (2016). 2023; 2023 Apr 14. PMID: 37123251.", + "The effect of the COVID-19 pandemic on community violence in Connecticut. O'Neill KM, Dodington J, Gawel M, Borrup K, Shapiro DS, Gates J, Gregg S, Becher RD. Am J Surg. 2023 Apr; 2022 Oct 7. PMID: 36253316.", + "How Good is Good Enough?: Current-Day Pediatric Residency Program Directors' Challenges in Assessing and Achieving Resident Procedural Competency. Forson-Dare Z, Du NR, Ocran A, Tiyyagura G, Bruno CJ, Johnston LC. Acad Pediatr. 2023 Mar; 2022 Nov 19. PMID: 36410602.", + "Child safety assessments during a caregiver's evaluation in emergency departments after intimate partner violence. Butala N, Asnes A, Gaither J, Leventhal JM, O'Malley S, Jubanyik K, Aydin A, Tiyyagura G. Acad Emerg Med. 2023 Jan; 2022 Nov 22. PMID: 36300559.", + "Improving Child Abuse Recognition and Management: Moving Forward with Clinical Decision Support. Tiyyagura G, Asnes AG, Leventhal JM. J Pediatr. 2023 Jan; 2022 Aug 17. PMID: 35987368.", + "Parental attitudes, beliefs, and practices related to firearm storage: a qualitative study. Schenck C, Wilson M, Tiyyagura G, Bechtel K. Inj Epidemiol. 2022 Dec 21; 2022 Dec 21. PMID: 36544237.", + "Evaluation for Bleeding Disorders in Suspected Child Abuse. Anderst J, Carpenter SL, Abshire TC, Killough E, Mendonca EA, Downs SM, Wetmore C, Allen C, Dickens D, Harper J, Rogers ZR, Jain J, Warwick A, Yates A, Hord J, Lipton J, Wilson H, Kirkwood S, Haney SB, Asnes AG, Gavril AR, Girardet RG, Heavilin N, Gilmartin ABH, Laskey A, Messner SA, Mohr BA, Nienow SM, Rosado N, Idzerda SM, Legano LA, Raj A, Sirotnak AP, Forkey HC, Keeshin B, Matjasko J, Edward H, Chavdar M, Di Paola J, Leavey P, Graham D, Hastings C, Hijiya N, Hord J, Matthews D, Pace B, Velez MC, Wechsler D, Billett A, Stork L, Hooker R. Pediatrics. 2022 Oct 1. PMID: 36180615.", + "Food Insecurity Screening and Intervention in United States Children's Hospitals. Markowitz MA, Tiyyagura G, Quallen K, Rosenberg J. Hosp Pediatr. 2022 Oct 1. PMID: 36120739.", + "The Evolving Needs of Children Hospitalized for Eating Disorders During the COVID-19 Pandemic. Shum M, Moreno C, Kamody R, McCollum S, Shabanova V, Loyal J. Hosp Pediatr. 2022 Aug 1. PMID: 35815415.", + "Prioritizing personal and team well-being: Lessons learned during the pandemic. Asnes AG, Kazmir S, Leventhal JM. Child Abuse Negl. 2022 Aug; 2022 Mar 22. PMID: 35331480.", + "Development and Validation of a Natural Language Processing Tool to Identify Injuries in Infants Associated With Abuse. Tiyyagura G, Asnes AG, Leventhal JM, Shapiro ED, Auerbach M, Teng W, Powers E, Thomas A, Lindberg DM, McClelland J, Kutryb C, Polzin T, Daughtridge K, Sevin V, Hsiao AL. Acad Pediatr. 2022 Aug; 2021 Nov 12. PMID: 34780997.", + "Bruising in Infants: An Approach to the Recognition of Child Physical Abuse. Asnes AG, Leventhal JM. Pediatr Rev. 2022 Jul 1. PMID: 35773541.", + "Revise and Resubmit. Langhan ML, Tiyyagura G. Acad Pediatr. 2022 Jul; 2022 Feb 10. PMID: 35151927.", + "Proxy Detection of Resident Burnout by Program Directors and Domestic Partners. Esposito AC, White EM, Coppersmith NA, Huot SJ, Asnes AG, Yoo PS, Solomon DG. J Am Coll Surg. 2022 Jun 1; 2022 Mar 11. PMID: 35703807.", + "The 21st Century Cures Act: Affecting the Safety of Intimate Partner Violence Survivors and Their Children. Shum M, Asnes AG, Jubanyik K, Tiyyagura G. Ann Emerg Med. 2022 May. PMID: 35461585.", + "Effect of a Novel Mindfulness Curriculum on Burnout During Pediatric Internship: A Cluster Randomized Clinical Trial. Fraiman YS, Cheston CC, Cabral HJ, Allen C, Asnes AG, Barrett JT, Batra M, Bernstein W, Bleeker T, Dietz PM, Lewis J, Li ST, Ma TM, Mahan JD, Michelson CD, Poynter SE, Vining MA, Watson K, Sox CM. JAMA Pediatr. 2022 Apr 1. PMID: 35072694.", + "Can Behavior-Based Interviews Reduce Bias in Fellowship Applicant Assessment? Langhan ML, Goldman MP, Tiyyagura G. Acad Pediatr. 2022 Apr; 2021 Dec 18. PMID: 34929389.", + "The Impact of Behavioral Anchors in the Assessment of Fellowship Applicants: Reducing Rater Biases. Langhan ML, Tiyyagura G. Acad Pediatr. 2022 Mar; 2021 Dec 2. PMID: 34864133.", + "Agreement With Pediatric Suprapatellar Bursa Effusion Assessments by Point-of-Care Ultrasound After Remote Training. Riera A, Leviter JI, Iqbal A, Soma G, Malik RN, Chen L. Pediatr Emerg Care. 2022 Feb 1. PMID: 34542989.", + "The impact of a child abuse guideline on differences between pediatric and community emergency departments in the evaluation of injuries. Shum M, Asnes AG, Leventhal JM, Gaither JR, Bechtel K, Powers E, Tiyyagura G. Child Abuse Negl. 2021 Dec; 2021 Oct 30. PMID: 34737120.", + "Closing the Loop: Program Description and Qualitative Analysis of a Pediatric Posttransfer Follow-up and Feedback Program. Goldman MP, Query LA, Wong AH, Gross IT, Emerson BL, Auerbach MA, Tiyyagura GK. Pediatr Emerg Care. 2021 Dec 1. PMID: 33009320.", + "A Community Emergency Department Rotation for Pediatric Emergency Medicine Fellows: Development and Evaluation. Langhan ML, Woolf S, Tiyyagura G. Pediatr Emerg Care. 2021 Dec 1. PMID: 32941360.", + "A QI Partnership to Decrease CT Use for Pediatric Appendicitis in the Community Hospital Setting. Goldman MP, Lynders W, Crain M, Nocera Kelley M, Solomon DM, Bokhari SAJ, Tiyyagura G, Auerbach MA, Emerson BL. Pediatr Qual Saf. 2021 Sep-Oct; 2021 Sep 24. PMID: 34589653.", + "Pediatric Rattlesnake Envenomation: A Simulation Scenario With Optional Health Equity, Virtual Facilitation, and Senior Learner Modifications. Joseph MN, Sanseau E, Thomas A, Brandehoff N, Augenstein J, Shuster M, Tiyyagura G, Auerbach M. Cureus. 2021 Sep; 2021 Sep 19. PMID: 34692317.", + "A 13-Year-Old With Fever and Chest Pain. Soma G, Simmons MA, Canarie MF, Karnik R, Steele J, Tiyyagura G, Asnes J. Pediatrics. 2021 Sep; 2021 Aug 3. PMID: 34344802.", + "Characteristics and scope of humanitarian relief forensic medical evaluations for immigrant children in the US. Rosenberg J, Edwards E, Wang KH, McKenzie KC, Asnes AG, Young J. J Forensic Leg Med. 2021 Aug; 2021 Jul 23. PMID: 34325082.", + "Origins and Early Management of Medical Child Abuse in Routine Pediatric Care. Hamilton JC, Leventhal JM, Asnes AG. JAMA Pediatr. 2021 Aug 1. PMID: 33999102.", + "Pediatric Emergency Medicine ECHO (Extension for Community Health Care Outcomes): Cultivating Connections to Improve Pediatric Emergency Care. Goldman MP, Auerbach MA, Garcia AM, Gross IT, Tiyyagura GK. AEM Educ Train. 2021 Jul; 2020 Nov 18. PMID: 34141996.", + "Hospital Admissions for Abusive Head Trauma at Children's Hospitals During COVID-19. Maassel NL, Asnes AG, Leventhal JM, Solomon DG. Pediatrics. 2021 Jul; 2021 Apr 20. PMID: 33879521.", + "High Hopes for Very Preterm Infants in Neonatal Intensive Care Units in China. Soma G, Chen L. JAMA Netw Open. 2021 Jun 1; 2021 Jun 1. PMID: 34137833.", + "The Use of Experts to Evaluate a Child Abuse Guideline in Community Emergency Departments. Shum M, Asnes A, Leventhal JM, Bechtel K, Gaither JR, Tiyyagura G. Acad Pediatr. 2021 Apr; 2020 Nov 5. PMID: 33160081.", + "Improving the Care of Abused Children Presenting to Community Emergency Departments: The Evolving Landscape. Tiyyagura G, Leventhal JM, Auerbach M, Schaeffer P, Asnes AG. Acad Pediatr. 2021 Mar; 2020 Sep 19. PMID: 32961336.", + "Medical Student Patient Outreach to Ensure Continuity of Care During the COVID-19 Pandemic. Belzer A, Yeagle EM, Kohlenberg LK, Solberg M, Gudbranson E, Budge M, Batchelor HM, Fitzpatrick SE, Zhao A, Armengol VD, Hassan SF, Shum M, Bia M, Bia F, Desai NR, Kahn PA. Telemed Rep. 2021; 2021 Feb 19. PMID: 35720754.", + "An evidence-based approach to nontraumatic ocular complaints in children. Iqbal A, Langhan ML, Rotruck J, Soma G. Pediatr Emerg Med Pract. 2021 Feb; 2021 Feb 2. PMID: 33476507.", + "Consultation for child physical abuse: Beyond the history and physical examination. Asnes AG, Pavlovic L, Moller B, Schaeffer P, Leventhal JM. Child Abuse Negl. 2021 Jan; 2020 Nov 4. PMID: 33158586.", + "Child Protection Team Consultation for Injuries Potentially Due to Child Abuse in Community Emergency Departments. Tiyyagura G, Emerson B, Gaither JR, Bechtel K, Leventhal JM, Becker H, Della Guistina K, Balga T, Mackenzie B, Shum M, Shapiro ED, Auerbach MA, McVaney C, Morrell P, Asnes AG. Acad Emerg Med. 2021 Jan; 2020 Oct 9. PMID: 32931628.", + "Seeing the Forest in Family Violence Research: Moving to a Family-Centered Approach. Tiyyagura G, Bloemen EM, Berger R, Rosen T, Harris T, Jeter G, Lindberg D. Acad Pediatr. 2020 Aug; 2020 Jan 25. PMID: 31991169.", + "Impact of statewide safe sleep legislation on hospital practices and rates of sudden unexpected infant deaths. Bechtel K, Gawel M, Vincent GA, Violano P. Inj Epidemiol. 2020 Jun 12; 2020 Jun 12. PMID: 32532344.", + "Parents' Perceptions of Infant Crying: A Possible Path to Preventing Abusive Head Trauma. Wiley M, Schultheis A, Francis B, Tiyyagura G, Leventhal JM, Rutherford HJV, Mayes LC, Bechtel K. Acad Pediatr. 2020 May-Jun; 2019 Oct 16. PMID: 31629119.", + "Parents' Perspective on Trainees Performing Invasive Procedures: A Qualitative Evaluation. McCarthy ML, Chaudoin LT, Mercurio MR, O'Brien EGJ, Bhargava S, Cohen SY, Auerbach M, Tiyyagura G. Pediatr Emerg Care. 2020 Feb. PMID: 28376068.", + "Fellows as Medical Educators: Implementation and Evaluation of a Curriculum to Improve Pediatric Fellow Teaching Skills. Timme KH, Hafler JP, Encandela J, Colson ER, Weinzimer SA, Asnes A, Gaither JR, Guest J, Murtha TD, Weiss P. Acad Pediatr. 2020 Jan-Feb; 2019 Jul 19. PMID: 31330315.", + "Community-based in situ simulation: bringing simulation to the masses. Walsh BM, Auerbach MA, Gawel MN, Brown LL, Byrne BJ, Calhoun A. Adv Simul (Lond). 2019; 2019 Dec 21. PMID: 31890313.", + "A Qualitative Analysis of General Emergency Medicine Providers' Perceptions on Pediatric Emergency Telemedicine. Kim JW, Tiyyagura G, Langhan M. Pediatr Emerg Care. 2019 Dec. PMID: 28225376.", + "Impact of Project ECHO on Community ED Providers' Perceptions of Child Abuse Knowledge and Access to Subspecialists for Child Abuse and Neglect. Tiyyagura G, Asnes AG, Leventhal JM, Shah A, Calabrese T, Radecki L, Jeter G, Auerbach M. Acad Pediatr. 2019 Nov-Dec; 2019 Jul 9. PMID: 31299431.", + "X + Y Scheduling in Pediatric Residency: Continuity, Handoffs, and Trainee Experience. Osborn R, Bullis E, Fenick AM, Powers E, Banker S, Asnes A. Acad Pediatr. 2019 Jul; 2019 May 9. PMID: 31077879.", + "Disclosure of caregiver-fabricated illness to a child: A team-based approach to communicating with pediatric patients. Cardona L, Asnes AG. Clin Child Psychol Psychiatry. 2019 Jul; 2019 Jan 9. PMID: 30623688.", + "Early Involvement of the Child Protection Team in the Care of Injured Infants in a Pediatric Emergency Department. Powers E, Tiyyagura G, Asnes AG, Leventhal JM, Moles R, Christison-Lagay E, Groisberg S, Auerbach M. J Emerg Med. 2019 Jun; 2019 Mar 14. PMID: 30879856.", + "A Qualitative Study Examining Stakeholder Perspectives of a Local Child Abuse Program in Community Emergency Departments. Tiyyagura G, Schaeffer P, Gawel M, Leventhal JM, Auerbach M, Asnes AG. Acad Pediatr. 2019 May-Jun; 2019 Jan 29. PMID: 30707955.", + "Oral injuries in children less than 24 months of age in a pediatric emergency department. Woolf SM, Leventhal JM, Gaither JR, Hardikar P, Langhan ML, Bechtel K, Auerbach MA, Tiyyagura G. Child Abuse Negl. 2019 Mar. PMID: 30639971.", + "The Impact of Telemedicine on Teamwork and Workload in Pediatric Resuscitation: A Simulation-Based, Randomized Controlled Study. Butler L, Whitfill T, Wong AH, Gawel M, Crispino L, Auerbach M. Telemed J E Health. 2019 Mar; 2018 Jun 29. PMID: 29957150.", + "A tabletop school bus rollover: Connecticut-wide drills to build pediatric disaster preparedness and promote a novel hospital disaster readiness checklist. Cicero MX, Golloshi K, Gawel M, Parker J, Auerbach M, Violano P. Am J Disaster Med. 2019 Spring. PMID: 31637688.", + "Adherence to Pediatric Cardiac Arrest Guidelines Across a Spectrum of Fifty Emergency Departments: A Prospective, In Situ, Simulation-based Study. Auerbach M, Brown L, Whitfill T, Baird J, Abulebda K, Bhatnagar A, Lutfi R, Gawel M, Walsh B, Tay KY, Lavoie M, Nadkarni V, Dudas R, Kessler D, Katznelson J, Ganghadaran S, Hamilton MF. Acad Emerg Med. 2018 Dec; 2018 Oct 25. PMID: 30194902.", + "A Grounded Theory Qualitative Analysis of Interprofessional Providers' Perceptions on Caring for Critically Ill Infants and Children in Pediatric and General Emergency Departments. Gangadharan S, Tiyyagura G, Gawel M, Walsh BM, Brown LL, Lavoie M, Tay KY, Auerbach MA. Pediatr Emerg Care. 2018 Aug. PMID: 27749805.", + "A Simulation-Based Quality Improvement Initiative Improves Pediatric Readiness in Community Hospitals. Whitfill T, Gawel M, Auerbach M. Pediatr Emerg Care. 2018 Jun. PMID: 28719479.", + "Occult abusive injuries in children brought for care after intimate partner violence: An exploratory study. Tiyyagura G, Christian C, Berger R, Lindberg D. Child Abuse Negl. 2018 May; 2018 Feb 20. PMID: 29452932.", + "A Qualitative Study of Multidisciplinary Providers' Experiences With the Transfer Process for Injured Children and Ideas for Improvement. Gawel M, Emerson B, Giuliano JS Jr, Rosenberg A, Minges KE, Feder S, Violano P, Morrell P, Petersen J, Christison-Lagay E, Auerbach M. Pediatr Emerg Care. 2018 Feb. PMID: 29346234.", + "Feasibility of providing child restraint devices after a motor vehicle crash in a pediatric emergency department. Violano P, Aysseh N, Lucas M, Gawel M, Morrell P, Norway C Jr, Alfano A, Bechtel K. Traffic Inj Prev. 2018; 2019 Jan 18. PMID: 30657709.", + "What Do Pediatricians Tell Parents About Bed-Sharing? Schaeffer P, Asnes AG. Matern Child Health J. 2018 Jan. PMID: 28766090.", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Fried Lab", + "lab_url": "https://medicine.yale.edu/lab/fried/", + "research_bio": "INFORMATION FOR The long–term goal of Dr. Fried’s research is to improve treatment decision-making for older persons with multiple chronic conditions. It seeks to enhance the frequency and quality of shared decision–making in order to provide patients with care that best meets their treatment preferences. In order to achieve this goal, her research has focused on: Copy Link", + "publications_page": "https://medicine.yale.edu/lab/fried/publications/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Geriatric Medicine /", + "Research", + "Publications", + "For Patients", + "Contact Us", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Publications", + "For Patients", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Efficacy of antiobesity medications for weight reduction in older adults: a systematic review. Chen AS, Hajduk AM, Grimshaw AA, Fried TR, Jastreboff AM, Lipska KJ. Obesity (Silver Spring). 2025 Nov; 2024 Dec 26. PMID: 39725567.", + "The COVID-19 Pandemic and Goals-of-Care Conversations in Veterans Health Administration Clinics. Linsky AM, Canter BE, Glickman M, Qian S, Ryan SK, Still M, Fried TR, Wiener RS. JAMA Netw Open. 2025 Jun 2; 2025 Jun 2. PMID: 40522660.", + "Communication as a key component of deprescribing: Conceptual framework and review of the literature. Fried TR, Ouyang N, Gnjidic D, Green A, Hilmer S, Holmes HM, Ko S, Mecca M, Reeve E, Reyes CE, Schoenborn NL, Singh R, Street R, Wahler RG Jr, Funaro MC. J Am Geriatr Soc. 2025 Mar; 2024 Dec 11. PMID: 39663187.", + "Desire for Prognostic Information Among Persons With Advanced Heart Failure. Blum M, Gelfman LP, Fried TR, McKendrick K, Schoenrath F, Goldstein NE. JACC Heart Fail. 2025 Mar; 2024 Aug 28. PMID: 39207322.", + "Emergency Department Visits Among Patients With Dementia Before and After Diagnosis. Gettel CJ, Song Y, Rothenberg C, Kitchen C, Gilmore-Bykovskyi A, Fried TR, Brody AA, Nothelle S, Wolff JL, Venkatesh AK. JAMA Netw Open. 2024 Oct 1; 2024 Oct 1. PMID: 39401040.", + "An innovative approach to aligning healthcare with what matters most to patients: A hybrid type 1 trial protocol of patient priorities care for older adults with multiple chronic conditions. Naik AD, Shanahan ML, Dindo L, Mecca MC, Arney J, Amspoker AB, Wydermyer S, Banks J, Street RL Jr, Kiefer L, Zenoni M, Rosen T, Gonzalez RD, Catic A, Fried TR. Contemp Clin Trials. 2024 Aug; 2024 Jun 22. PMID: 38914308.", + "Association Between Cognitive Trajectories and Subsequent Health Status, Depressive Symptoms, and Mortality Among Older Adults in the United States: Findings From a Nationally Representative Study. Zang E, Zhang Y, Wang Y, Wu B, Fried TR, Becher RD, Gill TM. J Gerontol A Biol Sci Med Sci. 2024 Aug 1. PMID: 38845419.", + "High-Intensity Care for Nursing Home Residents with Severe Dementia Hospitalized at the End of Life: A Mixed Methods Study. Cohen AB, McDonald WM, O'Leary JR, Omer ZB, Fried TR. J Am Med Dir Assoc. 2024 May; 2024 Mar 7. PMID: 38462230.", + "Diagnostic uncertainty and decision-making in home-based primary care: A qualitative study of antibiotic prescribing. Datta R, Kiwak E, Fried TR, Benjamin A, Iannone L, Krein SL, Carter W, Cohen AB. J Am Geriatr Soc. 2024 May; 2024 Jan 19. PMID: 38241465.", + "\"How can I be a caregiver for a second time?\" A call to action to acknowledge and support experienced family caregivers. Mroz EL, Fried TR, Monin JK. J Am Geriatr Soc. 2024 Mar; 2024 Jan 11. PMID: 38206857.", + "Personal Health Planning in Adult-Child Former Caregivers of Parents Living With Dementia. Mroz EL, Ali T, Piechota A, Matta-Singh TD, Abboud A, Sharma S, Monin JK, Fried TR. Am J Health Promot. 2024 Mar; 2023 Sep 28. PMID: 37770019.", + "Rewriting the Story of Mid- and Late-Life Family Caregiving: Applying a Narrative Identity Framework. Mroz EL, Monin JK, Gaugler JE, Matta-Singh TD, Fried TR. Gerontologist. 2024 Feb 1. PMID: 37018754.", + "Development of REDCap-based architecture for a clinical decision support tool linked to the electronic health record for assessment of medication appropriateness. Charpentier PA, Mecca MC, Brandt C, Fried TR. JAMIA Open. 2023 Jul; 2023 Jun 16. PMID: 37333904.", + "Antimicrobial resistance in Escherichia coli and Klebsiella pneumoniae urine isolates from a national sample of home-based primary care patients with dementia. Datta R, Pirruccio G, Fried TR, O'Leary JR, Zullo AR, Cohen A. Infect Control Hosp Epidemiol. 2023 May 22; 2023 May 22. PMID: 37211919.", + "\"Been there, done that:\" A grounded theory of future caregiver preparedness in former caregivers of parents living with dementia. Mroz EL, Piechota A, Ali T, Matta-Singh TD, Abboud A, Sharma S, White MA, Fried TR, Monin JK. J Am Geriatr Soc. 2023 May; 2022 Dec 26. PMID: 36571504.", + "Effect of Computer-Tailored Print Feedback, Motivational Interviewing, and Motivational Enhancement Therapy on Engagement in Advance Care Planning: A Randomized Clinical Trial. Fried TR, Yang M, Martino S, Iannone L, Zenoni M, Blakley L, O'Leary JR, Redding CA, Paiva AL. JAMA Intern Med. 2022 Dec 1. PMID: 36342678.", + "Giving up on the objective of providing goal-concordant care: Advance care planning for improving caregiver outcomes. Fried TR. J Am Geriatr Soc. 2022 Oct; 2022 Aug 16. PMID: 35974460.", + "Emergency department care transition barriers: A qualitative study of care partners of older adults with cognitive impairment. Gettel CJ, Serina PT, Uzamere I, Hernandez-Bigos K, Venkatesh AK, Cohen AB, Monin JK, Feder SL, Fried TR, Hwang U. Alzheimers Dement (N Y). 2022; 2022 Sep 28. PMID: 36204349.", + "Prediction of physical functioning and general health status trajectories on mortality among persons with cognitive impairment. Zang E, Wang X, Shi Y, Wu B, Fried TR. BMC Geriatr. 2022 Sep 21; 2022 Sep 21. PMID: 36131230.", + "Primary care clinicians' use of deprescribing recommendations: A mixed-methods study. Mecca MC, Zenoni M, Fried TR. Patient Educ Couns. 2022 Aug; 2022 Apr 22. PMID: 35523638.", + "Trajectories of General Health Status and Depressive Symptoms Among Persons With Cognitive Impairment in the United States. Zang E, Guo A, Pao C, Lu N, Wu B, Fried TR. J Aging Health. 2022 Aug-Sep; 2022 Jan 18. PMID: 35040695.", + "Increasing Engagement in Kitten Fostering Programs: Lessons Learned From High Kitten Intake Zip Codes in Los Angeles County. McDonald SE, Miller GS, Fried TR, Olmedo D, Matijczak A. Front Vet Sci. 2022; 2022 Jun 9. PMID: 35754537.", + "Trajectories of physical functioning among US adults with cognitive impairment. Zang E, Shi Y, Wang X, Wu B, Fried TR. Age Ageing. 2022 Jun 1. PMID: 35751871.", + "Perceived dementia risk and advance care planning among older adults. Lee YK, Fried TR, Costello DM, Hajduk AM, O'Leary JR, Cohen AB. J Am Geriatr Soc. 2022 May; 2022 Mar 11. PMID: 35274737.", + "Characteristics of Older Adults Who Cannot Identify a Healthcare Agent. Cohen AB, Paiva AL, Redding CA, Fried TR. J Gen Intern Med. 2022 Apr; 2021 Apr 26. PMID: 33904034.", + "Effect of the STAMP (Sharing and Talking About My Preferences) Intervention on Completing Multiple Advance Care Planning Activities in Ambulatory Care : A Cluster Randomized Controlled Trial. Fried TR, Paiva AL, Redding CA, Iannone L, O'Leary JR, Zenoni M, Risi MM, Mejnartowicz S, Rossi JS. Ann Intern Med. 2021 Nov; 2021 Aug 31. PMID: 34461035.", + "Engagement in Non-Medical End-of-Life Planning by Older Adults. Tu SS, O'Leary JR, Fried TR. J Pain Symptom Manage. 2021 Oct; 2021 Mar 12. PMID: 33716035.", + "Understanding the Role of Knowledge in Advance Care Planning Engagement. van Dyck LI, Paiva A, Redding CA, Fried TR. J Pain Symptom Manage. 2021 Oct; 2021 Feb 13. PMID: 33587993.", + "Anticoagulant Use for Atrial Fibrillation Among Persons With Advanced Dementia at the End of Life. Ouellet GM, Fried TR, Gilstrap LG, O'Leary JR, Austin AM, Skinner JS, Cohen AB. JAMA Intern Med. 2021 Aug 1. PMID: 33970197.", + "Prognostic information, goals of care, and code status decision-making among older patients. van Dyck LI, Fried TR. J Am Geriatr Soc. 2021 Jul; 2021 Mar 6. PMID: 33675032.", + "Prognosis as Health Trajectory: Educating Patients and Informing the Plan of Care. Thomas JM, Cooney LM Jr, Fried TR. J Gen Intern Med. 2021 Jul; 2021 Jan 5. PMID: 33403621.", + "Early Changes in Rates of Documented Goals-of-Care Conversations in the Veterans Health Administration During the COVID-19 Pandemic. Wiener RS, Kim SYI, Fried TR, Cohen J, Foglia MB, Lehmann LS, Linsky AM. J Gen Intern Med. 2021 May; 2021 Mar 9. PMID: 33751412.", + "Cognitively Impaired Older Persons' and Caregivers' Perspectives on Dementia-Specific Advance Care Planning. Fried TR, Cohen AB, Harris JE, Moreines L. J Am Geriatr Soc. 2021 Apr; 2020 Nov 20. PMID: 33216955.", + "Guardianship and End-of-Life Care for Veterans with Dementia in Nursing Homes. Cohen AB, Han L, OʼLeary JR, Fried TR. J Am Geriatr Soc. 2021 Feb; 2020 Nov 10. PMID: 33170957.", + "Older Adults without Desired Surrogates in a Nationally Representative Sample. Cohen AB, Costello DM, OʼLeary JR, Fried TR. J Am Geriatr Soc. 2021 Jan; 2020 Sep 8. PMID: 32898285.", + "Reply to: Outcomes and Patient Goals: Comment on \"Chronic Disease Decision Making and 'What Matters Most'\". Fried TR, Street RL Jr, Cohen AB. J Am Geriatr Soc. 2020 Jul; 2020 May 11. PMID: 32391923.", + "Reply to Comment on: End-of-Life Decision Making and Treatment for Patients With Professional Guardians. Cohen AB, Fried TR. J Am Geriatr Soc. 2020 Apr; 2020 Feb 29. PMID: 32112564.", + "Physician Orders for Life-Sustaining Treatment and Limiting Overtreatment at the End of Life. Truog RD, Fried TR. JAMA. 2020 Mar 10. PMID: 32062673.", + "Chronic Disease Decision Making and \"What Matters Most\". Fried TR, Street RL Jr, Cohen AB. J Am Geriatr Soc. 2020 Mar; 2020 Feb 11. PMID: 32043559.", + "Reply to Measuring Under- and Over-Use of Medications. Fried TR, Mecca M. J Am Geriatr Soc. 2019 Nov; 2019 Aug 7. PMID: 31390042.", + "End-of-Life Decision Making and Treatment for Patients with Professional Guardians. Cohen AB, Benjamin AZ, Fried TR. J Am Geriatr Soc. 2019 Oct; 2019 Jul 13. PMID: 31301189.", + "Feasibility of Delivering a Tailored Intervention for Advance Care Planning in Primary Care Practice. Paiva A, Redding CA, Iannone L, Zenoni M, O'Leary JR, Fried TR. J Am Geriatr Soc. 2019 Sep; 2019 Jul 4. PMID: 31271654.", + "Assessing an Interprofessional Polypharmacy and Deprescribing Educational Intervention for Primary Care Post-graduate Trainees: a Quantitative and Qualitative Evaluation. Mecca MC, Thomas JM, Niehoff KM, Hyson A, Jeffery SM, Sellinger J, Mecca AP, Van Ness PH, Fried TR, Brienza R. J Gen Intern Med. 2019 Jul; 2019 Apr 10. PMID: 30972554.", + "Prognosis Reconsidered in Light of Ancient Insights-From Hippocrates to Modern Medicine. Thomas JM, Cooney LM Jr, Fried TR. JAMA Intern Med. 2019 Jun 1. PMID: 30958502.", + "Medication Appropriateness in Vulnerable Older Adults: Healthy Skepticism of Appropriate Polypharmacy. Fried TR, Mecca MC. J Am Geriatr Soc. 2019 Jun; 2019 Jan 30. PMID: 30697698.", + "Communication About Treatment Options and Shared Decision Making in the Intensive Care Unit. Fried TR. JAMA Intern Med. 2019 May 1. PMID: 30933240.", + "Assessment of Surrogates' Knowledge of Patients' Treatment Goals and Confidence in Their Ability to Make Surrogate Treatment Decisions. Fried TR, Zenoni M, Iannone L, O'Leary JR. JAMA Intern Med. 2019 Feb 1. PMID: 30477019.", + "Medication appropriateness criteria for older adults: a narrative review of criteria and supporting studies. Niehoff KM, Mecca MC, Fried TR. Ther Adv Drug Saf. 2019; 2019 Jan 18. PMID: 30719279.", + "Characteristics of Patients With Professional Guardians in the Department of Veterans Affairs Health Care System. Cohen AB, Trentalange M, Benjamin AZ, Fried TR. JAMA Intern Med. 2019 Jan 1. PMID: 30398533.", + "Increasing engagement in advance care planning using a behaviour change model: study protocol for the STAMP randomised controlled trials. Fried TR, Redding CA, Martino S, Paiva A, Iannone L, Zenoni M, Blakley LA, Rossi JS, O'Leary J. BMJ Open. 2018 Aug 10; 2018 Aug 10. PMID: 30099405.", + "Development and Pilot Testing of a Motivational Interview for Engagement in Advance Care Planning. Fried TR, Leung SL, Blakley LA, Martino S. J Palliat Med. 2018 Jul. PMID: 29975613.", + "Defining the Scope of Prognosis: Primary Care Clinicians' Perspectives on Predicting the Future Health of Older Adults. Thomas JM, Fried TR. J Pain Symptom Manage. 2018 May; 2018 Feb 5. PMID: 29421166.", + "Effect of the Tool to Reduce Inappropriate Medications on Medication Communication and Deprescribing. Fried TR, Niehoff KM, Street RL, Charpentier PA, Rajeevan N, Miller PL, Goldstein MK, O'Leary JR, Fenton BT. J Am Geriatr Soc. 2017 Oct; 2017 Aug 14. PMID: 28804870.", + "Engagement in Advance Care Planning and Surrogates' Knowledge of Patients' Treatment Goals. Fried TR, Zenoni M, Iannone L, O'Leary J, Fenton BT. J Am Geriatr Soc. 2017 Aug; 2017 Mar 20. PMID: 28317097.", + "Utilizing patient data from the veterans administration electronic health record to support web-based clinical decision support: informatics challenges and issues from three clinical domains. Rajeevan N, Niehoff KM, Charpentier P, Levin FL, Justice A, Brandt CA, Fried TR, Miller PL. BMC Med Inform Decis Mak. 2017 Jul 19; 2017 Jul 19. PMID: 28724368.", + "Do-Not-Hospitalize Orders in Nursing Homes: \"Call the Family Instead of Calling the Ambulance\". Cohen AB, Knobf MT, Fried TR. J Am Geriatr Soc. 2017 Jul; 2017 Mar 30. PMID: 28369740.", + "Avoiding Hospitalizations From Nursing Homes for Potentially Burdensome Care: Results of a Qualitative Study. Cohen AB, Knobf MT, Fried TR. JAMA Intern Med. 2017 Jan 1. PMID: 27893891.", + "Patient-defined goals for the treatment of severe aortic stenosis: a qualitative analysis. Coylewright M, Palmer R, O'Neill ES, Robb JF, Fried TR. Health Expect. 2016 Oct; 2015 Aug 14. PMID: 26275070.", + "Erratum to: A Delphi process to address medication appropriateness for older persons with multiple chronic conditions. Fried TR, Niehoff K, Tjia J, Redeker N, Goldstein MK. BMC Geriatr. 2016 Jun 16; 2016 Jun 16. PMID: 27312251.", + "Development of the Tool to Reduce Inappropriate Medications (TRIM): A Clinical Decision Support System to Improve Medication Prescribing for Older Adults. Niehoff KM, Rajeevan N, Charpentier PA, Miller PL, Goldstein MK, Fried TR. Pharmacotherapy. 2016 Jun; 2016 May 28. PMID: 27041466.", + "Vulvovaginal symptoms prevalence in postmenopausal women and relationship to other menopausal symptoms and pelvic floor disorders. Erekson EA, Li FY, Martin DK, Fried TR. Menopause. 2016 Apr. PMID: 26645820.", + "A Delphi process to address medication appropriateness for older persons with multiple chronic conditions. Fried TR, Niehoff K, Tjia J, Redeker N, Goldstein MK. BMC Geriatr. 2016 Mar 15; 2016 Mar 15. PMID: 26979576.", + "Development of Personalized Health Messages to Promote Engagement in Advance Care Planning. Fried TR, Redding CA, Robbins ML, Paiva AL, O'Leary JR, Iannone L. J Am Geriatr Soc. 2016 Feb; 2016 Jan 25. PMID: 26804791.", + "Shared Decision Making--Finding the Sweet Spot. Fried TR. N Engl J Med. 2016 Jan 14. PMID: 26760081.", + "Older Adults' Recognition of Trade-Offs in Healthcare Decision-Making. Case SM, O'Leary J, Kim N, Tinetti ME, Fried TR. J Am Geriatr Soc. 2015 Aug; 2015 Jul 14. PMID: 26173743.", + "Frailty, cognitive impairment, and functional disability in older women with female pelvic floor dysfunction. Erekson EA, Fried TR, Martin DK, Rutherford TJ, Strohbehn K, Bynum JP. Int Urogynecol J. 2015 Jun; 2014 Dec 17. PMID: 25516232.", + "Functional disability and compromised mobility among older women with urinary incontinence. Erekson EA, Ciarleglio MM, Hanissian PD, Strohbehn K, Bynum JP, Fried TR. Female Pelvic Med Reconstr Surg. 2015 May-Jun. PMID: 25185600.", + "Health care worker attitudes and identified barriers to patient sleep in the medical intensive care unit. Hopper K, Fried TR, Pisani MA. Heart Lung. 2015 Mar-Apr; 2015 Feb 14. PMID: 25686516.", + "Decision-making and cancer screening: a qualitative study of older adults with multiple chronic conditions. Gross CP, Fried TR, Tinetti ME, Ross JS, Genao I, Hossain S, Wolf E, Lewis CL. J Geriatr Oncol. 2015 Mar; 2014 Dec 17. PMID: 25544380.", + "Functional disability among older women with fecal incontinence. Erekson EA, Ciarleglio MM, Hanissian PD, Strohbehn K, Bynum JP, Fried TR. Am J Obstet Gynecol. 2015 Mar; 2014 Oct 15. PMID: 25447956.", + "Health outcomes associated with polypharmacy in community-dwelling older adults: a systematic review. Fried TR, O'Leary J, Towle V, Goldstein MK, Trentalange M, Martin DK. J Am Geriatr Soc. 2014 Dec. PMID: 25516023.", + "The effects of comorbidity on the benefits and harms of treatment for chronic disease: a systematic review. Fried TR, O'Leary J, Towle V, Goldstein MK, Trentelange M, Martin DK. PLoS One. 2014; 2014 Nov 17. PMID: 25402463.", + "Relationship between universal health outcome priorities and willingness to take medication for primary prevention of myocardial infarction. Case SM, O'Leary J, Kim N, Tinetti ME, Fried TR. J Am Geriatr Soc. 2014 Sep; 2014 Aug 22. PMID: 25146885.", + "A comparison of the willingness of resident and attending physicians to comply with the requests of patients at the end of life. Thomas JM, O'Leary JR, Fried TR. J Gen Intern Med. 2014 Jul; 2014 Mar 20. PMID: 24647724.", + "Over-the-counter treatments and perineal hygiene in postmenopausal women. Erekson EA, Martin DK, Brousseau EC, Yip SO, Fried TR. Menopause. 2014 Mar. PMID: 23880795.", + "The Vulvovaginal Symptoms Questionnaire: a questionnaire for measuring vulvovaginal symptoms in postmenopausal women. Erekson EA, Yip SO, Wedderburn TS, Martin DK, Li FY, Choi JN, Kenton KS, Fried TR. Menopause. 2013 Sep. PMID: 23481118.", + "Advance care planning beyond advance directives: perspectives from patients and surrogates. McMahan RD, Knight SJ, Fried TR, Sudore RL. J Pain Symptom Manage. 2013 Sep; 2012 Nov 27. PMID: 23200188.", + "Considering the balance: development of a scale to assess patient views on trade-offs in competing health outcomes. Case SM, Towle VR, Fried TR. J Am Geriatr Soc. 2013 Aug; 2013 Jul 19. PMID: 23869795.", + "Systematic review: Health-related characteristics of elderly hospitalized adults and nursing home residents associated with short-term mortality. Thomas JM, Cooney LM Jr, Fried TR. J Am Geriatr Soc. 2013 Jun; 2013 May 20. PMID: 23692412.", + "Trajectories of posttraumatic stress symptomatology in older persons affected by a large-magnitude disaster. Pietrzak RH, Van Ness PH, Fried TR, Galea S, Norris FH. J Psychiatr Res. 2013 Apr; 2013 Jan 4. PMID: 23290559.", + "How to ask: older adults' preferred tools in health outcome prioritization. Case SM, Fried TR, O'Leary J. Patient Educ Couns. 2013 Apr; 2012 Dec 4. PMID: 23218242.", + "Patient preferences for deactivation of implantable cardioverter-defibrillators. Dodson JA, Fried TR, Van Ness PH, Goldstein NE, Lampert R. JAMA Intern Med. 2013 Mar 11. PMID: 23358714.", + "The practitioner proposes a treatment change and the patient declines: what to do next? Falzer PR, Leventhal HL, Peters E, Fried TR, Kerns R, Michalski M, Fraenkel L. Pain Pract. 2013 Mar; 2012 Jul 2. PMID: 23462141.", + "Guiding principles for the care of older adults with multimorbidity: an approach for clinicians: American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity. J Am Geriatr Soc. 2012 Oct; 2012 Sep 19. PMID: 22994865.", + "Diagnostic utility and factor structure of the PTSD Checklist in older adults. Pietrzak RH, Van Ness PH, Fried TR, Galea S, Norris F. Int Psychogeriatr. 2012 Oct; 2012 May 30. PMID: 22647669.", + "Caring for the older person with chronic obstructive pulmonary disease. Fried TR, Vaz Fragoso CA, Rabow MW. JAMA. 2012 Sep 26. PMID: 23011715.", + "Major postoperative complications after benign gynecologic surgery: a clinical prediction tool. Erekson EA, Yip SO, Martin DK, Ciarleglio MM, Connell KA, Fried TR. Female Pelvic Med Reconstr Surg. 2012 Sep-Oct. PMID: 22983270.", + "A pilot randomized controlled trial of a decision support tool to improve the quality of communication and decision-making in individuals with atrial fibrillation. Fraenkel L, Street RL Jr, Towle V, O'Leary JR, Iannone L, Van Ness PH, Fried TR. J Am Geriatr Soc. 2012 Aug; 2012 Aug 2. PMID: 22861171.", + "Designing health care for the most common chronic condition--multimorbidity. Tinetti ME, Fried TR, Boyd CM. JAMA. 2012 Jun 20. PMID: 22797447.", + "Gynecologic surgery in the geriatric patient. Erekson EA, Ratner ES, Walke LM, Fried TR. Obstet Gynecol. 2012 Jun. PMID: 22617593.", + "Influence of patient age and comorbid burden on clinician attitudes toward heart failure guidelines. Steinman MA, Sudore RL, Peterson CA, Harlow JB, Fried TR. Am J Geriatr Pharmacother. 2012 Jun; 2012 May 12. PMID: 22579695.", + "Impact of comorbidity on mortality among older persons with advanced heart failure. Ahluwalia SC, Gross CP, Chaudhry SI, Ning YM, Leo-Summers L, Van Ness PH, Fried TR. J Gen Intern Med. 2012 May; 2011 Nov 18. PMID: 22095572.", + "Promoting advance care planning as health behavior change: development of scales to assess Decisional Balance, Medical and Religious Beliefs, and Processes of Change. Fried TR, Redding CA, Robbins ML, Paiva A, O'Leary JR, Iannone L. Patient Educ Couns. 2012 Jan; 2011 Jul 7. PMID: 21741194.", + "Health outcome prioritization as a tool for decision making among older persons with multiple chronic conditions. Fried TR, Tinetti ME, Iannone L, O'Leary JR, Towle V, Van Ness PH. Arch Intern Med. 2011 Nov 14; 2011 Sep 26. PMID: 21949032.", + "Development of a tool to improve the quality of decision making in atrial fibrillation. Fraenkel L, Street RL Jr, Fried TR. BMC Med Inform Decis Mak. 2011 Oct 6; 2011 Oct 6. PMID: 21977943.", + "Mixed Methods for the Interpretation of Longitudinal Gerontologic Data: Insights From Philosophical Hermeneutics. Van Ness PH, Fried TR, Gill TM. J Mix Methods Res. 2011 Oct; 2011 Jul 13. PMID: 22582035.", + "Postoperative complications after gynecologic surgery. Erekson EA, Yip SO, Ciarleglio MM, Fried TR. Obstet Gynecol. 2011 Oct. PMID: 21934441.", + "Change in comorbidity prevalence with advancing age among persons with heart failure. Ahluwalia SC, Gross CP, Chaudhry SI, Leo-Summers L, Van Ness PH, Fried TR. J Gen Intern Med. 2011 Oct; 2011 May 15. PMID: 21573881.", + "Effect of chronic disease-related symptoms and impairments on universal health outcomes in older adults. Tinetti ME, McAvay G, Chang SS, Ning Y, Newman AB, Fitzpatrick A, Fried TR, Harris TB, Nevitt MC, Satterfield S, Yaffe K, Peduzzi P. J Am Geriatr Soc. 2011 Sep; 2011 Aug 24. PMID: 21883120.", + "Contribution of multiple chronic conditions to universal health outcomes. Tinetti ME, McAvay GJ, Chang SS, Newman AB, Fitzpatrick AL, Fried TR, Peduzzi PN. J Am Geriatr Soc. 2011 Sep; 2011 Aug 30. PMID: 21883118.", + "VA Connecticut Healthcare 950 Campbell Avenue West Haven, CT 06516", + "2 Events you could attend in November 2025 Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Fucito Lab", + "lab_url": "https://medicine.yale.edu/lab/fucito/", + "research_bio": "INFORMATION FOR The Fucito Lab is committed to reducing the public health burden of substance use with a particular focus on alcohol and tobacco use. To achieve this aim, we conduct innovative clinical research in three key areas: We utilize a range of research methods including clinical trials, longitudinal observational studies, experience sampling with diaries and wearables, qualitative and user-centered design methods, and implementation science. Dr. Fucito, a Clinical Psychologist, is both an active researcher and hospital-based clinician/administrator, and an expert in alcohol and tobacco use and treatment. She has conducted seminal research in several areas including sleep health as a risk factor and intervention target for alcohol and tobacco use, wearable biofeedback interventions that integrate multiple health biometrics, e-cigarette cessation, and oral nicotine pouches. Additionally, she has served on multiple tobacco treatment clinical practice guidelines and consensus statements. Copy Link Dr. Fucito directs this Service, which provides medical and counseling support statewide to adults seeking help for any form of tobacco or nicotine product use. Individuals referred to the Service can participate in the regular program or clinical trials for which they may be eligible. To date, the Service has supported 10+ clinical trials including treatment for e-cigarette use, smoking cessation prior to cancer surgery, and switching from cigarettes to e-cigarettes or oral nicotine pouches. Copy Link Dr. Fucito is a faculty supervisor and advisor for theYale Doctoral Internship in Clinical and Community Psychology,Yale New Haven Hospital Behavioral Medicine Placement Site. Trainees of this program can complete scholarly projects through the Fucito Lab. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/fucito/publications", + "publications": null + }, + { + "lab_name": "Gastric Cancer Prevention and Screening Lab", + "lab_url": "https://medicine.yale.edu/lab/gastric-cancer-prevention/", + "research_bio": "INFORMATION FOR Copy Link The Gastric Cancer Prevention and Screening Lab at Yale is a multidisciplinary research group focused on improving early detection and prevention of gastric cancer through clinically grounded, risk-based strategies. Our work bridges research and practice by developing tools to support provider education, refining risk assessment models, and conducting real-world studies in high-risk populations. Through provider engagement, migration-informed risk modeling, and collaborative implementation research—including partnerships with advocacy groups and policymakers—we aim to generate actionable insights that inform clinical practice, guide public health strategies, and expand equitable access to screening and early intervention. Our lab conducts clinically grounded, policy-relevant research to reduce the burden of gastric cancer through risk-based early detection and prevention strategies. Our work bridges gastroenterology, public health, and health equity, with a focus on immigrant and high-risk populations in the U.S.", + "publications_page": "https://medicine.yale.edu/lab/gastric-cancer-prevention/publications", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Digestive Diseases /", + "Research & Projects", + "People", + "Advocacy and Policy", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research & Projects", + "People", + "Advocacy and Policy", + "Publications", + "", + "", + "", + "", + "", + "", + "Population screening for Helicobacter pylori to reduce gastric cancer - Authors' reply. Sundar R, Hyun CS, Smyth EC. Lancet. 2025 Nov 1. PMID: 41176388.", + "A Migration-Informed, Risk-Based Approach to H. pylori Screening and Gastric Cancer Prevention in the U.S. Hyun CS. Korean J Helicobacter Up Gastrointest Res. 2025 Sep; 2025 Sep 1. PMID: 40935620.", + "Rethinking gastric cancer prevention through an immigrant health lens. Hyun CS, Oh SS, Wu L, Moy RH, Shin JI. Nat Rev Gastroenterol Hepatol. 2025 Sep. PMID: 40691298.", + "Long term outcome of a community-based hepatitis B awareness campaign: eight-year follow-up on linkage to care (LTC) in HBV infected individuals. Hyun CS, Ko O, Lee S, McMenamin J. BMC Infect Dis. 2019 Jul 18; 2019 Jul 18. PMID: 31319805.", + "The prevalence and significance of isolated hepatitis B core antibody (anti-HBc) in endemic population. Hyun CS, Lee S, Ventura WR. BMC Res Notes. 2019 May 6; 2019 May 6. PMID: 31060623.", + "Chronic hepatitis B in Korean Americans: decreased prevalence and poor linkage to care. Hyun CS, Kim S, Kang SY, Jung S, Lee S. BMC Infect Dis. 2016 Aug 15; 2016 Aug 15. PMID: 27526685.", + "A community- based hepatitis B linkage-to-care program: a case study on Asian Americans chronically infected with hepatitis B virus. Hyun CS, Ventura WR, Kim SS, Yoon S, Lee S. Hepatol Med Policy. 2016; 2016 May 5. PMID: 30288310.", + "Morphological factors influencing transepithelial conductance in a rabbit model of ileitis. Hyun CS, Chen CW, Shinowara NL, Palaia T, Fallick FS, Martello LA, Mueenuddin M, Donovan VM, Teichberg S. Gastroenterology. 1995 Jul. PMID: 7797012.", + "Identification of protein kinase C-alpha, epsilon and zeta in rabbit ileal enterocytes. Hyun CS, Martello LA, Karl PI. Comp Biochem Physiol Pharmacol Toxicol Endocrinol. 1994 Jul. PMID: 7981979.", + "Ion transport in rabbit proximal colon: effects of sodium, amiloride, cAMP, and epinephrine. Hyun CS, Ahn J, Minhas BS, Cragoe EJ Jr, Field M. Am J Physiol. 1994 Jun. PMID: 8023939.", + "Mechanism of leukotriene D4 stimulation of Cl- secretion in rat distal colon in vitro. Hyun CS, Binder HJ. Am J Physiol. 1993 Sep. PMID: 8214069.", + "Alpha 2-adrenergic receptor-mediated regulation of intestinal calcium transport. Hyun CS, Cragoe EJ Jr, Field M. Am J Physiol. 1985 Jul. PMID: 2861745.", + "Interaction of cholera toxin and Escherichia coli enterotoxin with isolated intestinal epithelial cells. Hyun CS, Kimmich GA. Am J Physiol. 1984 Dec. PMID: 6095676.", + "Effect of cholera toxin on cAMP levels and Na+ influx in isolated intestinal epithelial cells. Hyun CS, Kimmich GA. Am J Physiol. 1982 Sep. PMID: 6287857.", + "Maps & Directions", + "3 Events you could attend in November 2025 Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Gehlhausen Lab", + "lab_url": "https://medicine.yale.edu/lab/gehlhausen/", + "research_bio": "INFORMATION FOR My research program –working as a part of a larger group of researchers in the lab of Akiko Iwasaki, PhD– focuses on the biology of autoimmune inflammatory skin diseases. To accomplish our research, we utilize unique genetic mouse models of autoimmunity, in addition to patient samples from autoimmune skin disease patients who I see in my clinic. While our work is currently focused on lupus erythematosus, we plan to extend our observations to other relevant skin diseases like dermatomyositis that on some levels appear to have shared molecular and cellular biology. To accomplish these studies, we regularly employ a mix of both standard and newer technologies including high parameter flow cytometry, bulk RNA sequencing, single cell RNA sequencing, in addition to spatial transcriptomic analyses: Copy Link Principal Investigator Assistant Professor in Dermatology Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Geibel Lab", + "lab_url": "https://medicine.yale.edu/lab/geibel/", + "research_bio": "INFORMATION FOR Our primary focus is on real time monitoring of ion transport mechanisms in epithelia, using high-resolution microscopy. One of the crucial problems facing all epithelial cells is the control of the intracellular milieu. In an effort to maintain ionic homeostasis, epithelial cells have devised a variety of ion channels, transport proteins, and carriers to regulate and maintain the intracellular ionic concentrations. To further understand how ions are transported in epithelial cells, we have developed a variety of optical techniques to continuously monitor intracellular ionic concentrations in real time. Using high-resolution video or confocal microscopy we are presently able to monitor intracellular Ca2+, Na+, K+, Cl-, pH, and membrane potential. We are currently investigating various aspects of renal tubule and gastric tissue ion transport in intact renal tubules and gastric glands. We also are characterizing the secretory and reabsorptive properties of the colonic crypt, with a special focus on diarrheal disease. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/geibel/pubs/", + "publications": [ + "Yale School of Medicine /", + "Surgery /", + "Research", + "Contact Us", + "Principal Investigator", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Principal Investigator", + "Publications", + "News", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Development and deployment of a functional 3D-bioprinted blood vessel. Dell AC, Maresca J, Davis BA, Isaji T, Dardik A, Geibel JP. Sci Rep. 2025 Apr 5; 2025 Apr 5. PMID: 40188212.", + "Application of a 3D bioprinter: jet technology for 'biopatch' development using cells on hydrogel supports. DeMel DC, Wagner GA, Maresca JA, Geibel JP. Biotechniques. 2024 Feb; 2023 Dec 12. PMID: 38084384.", + "Three-Dimensional Bioprinting Applications for Bone Tissue Engineering. Maresca JA, DeMel DC, Wagner GA, Haase C, Geibel JP. Cells. 2023 Apr 24; 2023 Apr 24. PMID: 37174630.", + "3D Bioprinting Using Hydrogels: Cell Inks and Tissue Engineering Applications. Dell AC, Wagner G, Own J, Geibel JP. Pharmaceutics. 2022 Nov 24; 2022 Nov 24. PMID: 36559090.", + "Colonic Fluid and Electrolyte Transport 2022: An Update. Negussie AB, Dell AC, Davis BA, Geibel JP. Cells. 2022 May 22; 2022 May 22. PMID: 35626748.", + "3D Bioprinting of Vascularized Tissues for in vitro and in vivo Applications. Chen EP, Toksoy Z, Davis BA, Geibel JP. Front Bioeng Biotechnol. 2021; 2021 May 13. PMID: 34055761.", + "Hydrogel-based 3D bioprints repair rat small intestine injuries and integrate into native intestinal tissue. Maina RM, Barahona MJ, Geibel P, Lysyy T, Finotti M, Isaji T, Wengerter B, Mentone S, Dardik A, Geibel JP. J Tissue Eng Regen Med. 2021 Feb; 2020 Dec 1. PMID: 33197151.", + "Penicillin G Induces H+, K+-ATPase via a Nitric Oxide-Dependent Mechanism in the Rat Colonic Crypt. Baratta VM, Norz V, Barahona MJ, Gisinger TM, Mulligan D, Geibel JP. Cell Physiol Biochem. 2020 Nov 12. PMID: 33175479.", + "In Pursuit of the Parietal Cell - An Evolution of Scientific Methodology and Techniques. Baratta V, Own J, Di Renzo C, Ollodart J, Geibel JP, Barahona M. Front Physiol. 2019; 2019 Dec 12. PMID: 31920702.", + "Induction of Secretagogue Independent Gastric Acid Secretion via a Novel Aspirin-Activated Pathway. Kitay AM, Ferstl FS, Link A, Geibel JP. Front Physiol. 2019; 2019 Oct 10. PMID: 31649553.", + "The calcium-sensing receptor: A novel target for treatment and prophylaxis of neratinib-induced diarrhea. Lysyy T, Lalani AS, Olek EA, Diala I, Geibel JP. Pharmacol Res Perspect. 2019 Oct; 2019 Sep 13. PMID: 31523434.", + "Activation of the Calcium Sensing Receptor Decreases Secretagogue-Induced Fluid Secretion in the Rat Small Intestine. Barahona MJ, Maina RM, Lysyy T, Finotti M, Caturegli G, Baratta V, D'Amico F, Mulligan D, Geibel JP. Front Physiol. 2019; 2019 May 3. PMID: 31130866.", + "Design and implementation of novel nutraceuticals and derivatives for treating intestinal disorders. Barahona MJ, Baratta V, Ollodart J, Mulligan D, Geibel JP. Future Med Chem. 2019 Apr; 2019 Apr 17. PMID: 30994367.", + "Generating vascular conduits: from tissue engineering to three-dimensional bioprinting. Maina RM, Barahona MJ, Finotti M, Lysyy T, Geibel P, D'Amico F, Mulligan D, Geibel JP. Innov Surg Sci. 2018 Sep; 2018 Jun 27. PMID: 31579784.", + "Modulations in extracellular calcium lead to H(+)-ATPase-dependent acid secretion: a clarification of PPI failure. Kitay AM, Schneebacher MT, Schmitt A, Heschl K, Kopic S, Alfadda T, Alsaihati A, Link A, Geibel JP. Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1; 2018 Mar 8. PMID: 29517927.", + "Modulation of Intestinal Microbiome Prevents Intestinal Ischemic Injury. Bertacco A, Dehner CA, Caturegli G, D'Amico F, Morotti R, Rodriguez MI, Mulligan DC, Kriegel MA, Geibel JP. Front Physiol. 2017; 2017 Dec 19. PMID: 29311987.", + "Use of Fluorescein Isothiocyanate-Inulin as a Marker for Intestinal Ischemic Injury. AlKukhun A, Caturegli G, Munoz-Abraham AS, Judeeba S, Patron-Lozano R, Morotti R, Rodriguez-Davalos MI, Geibel JP. J Am Coll Surg. 2017 Jun; 2016 Dec 23. PMID: 28017811.", + "Activation of Secretagogue Independent Gastric Acid Secretion via Endothelial Nitric Oxide Synthase Stimulation in Rats. Kitay AM, Link A, Geibel JP. Cell Physiol Biochem. 2017; 2017 Dec 6. PMID: 29212068.", + "Acute Effects of Vitamin C Exposure On Colonic Crypts: Direct Modulation of pH Regulation. Aldajani MM, Vanicek CN, Alhazzaa N, Lysyy T, Agarwal R, Geibel JP. Cell Physiol Biochem. 2017; 2017 Nov 13. PMID: 29132138.", + "Stomach and Bone. Kitay AM, Geibel JP. Adv Exp Med Biol. 2017. PMID: 29101653.", + "Secretagogue-dependent and -independent transport of zinc hydration forms in rat parietal cells. Ferstl FS, Kitay AM, Trattnig RM, Alsaihati A, Geibel JP. Pflugers Arch. 2016 Nov; 2016 Oct 19. PMID: 27757581.", + "Extracorporeal Hypothermic Perfusion Device for Intestinal Graft Preservation to Decrease Ischemic Injury During Transportation. Muñoz-Abraham AS, Patrón-Lozano R, Narayan RR, Judeeba SS, Alkukhun A, Alfadda TI, Belter JT, Mulligan DC, Morotti R, Zinter JP, Geibel JP, Rodríguez-Dávalos MI. J Gastrointest Surg. 2016 Feb. PMID: 26487331.", + "A new method to measure intestinal secretion using fluorescein isothiocyanate-inulin in small bowel of rats. Munoz-Abraham AS, Judeeba S, Alkukhun A, Alfadda T, Patron-Lozano R, Rodriguez-Davalos MI, Geibel JP. J Surg Res. 2015 Aug; 2015 Apr 20. PMID: 25976849.", + "Kir1.1 (ROMK) and Kv7.1 (KCNQ1/KvLQT1) are essential for normal gastric acid secretion: importance of functional Kir1.1. Vucic E, Alfadda T, MacGregor GG, Dong K, Wang T, Geibel JP. Pflugers Arch. 2015 Jul; 2014 Aug 17. PMID: 25127675.", + "Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium. McNeer NA, Anandalingam K, Fields RJ, Caputo C, Kopic S, Gupta A, Quijano E, Polikoff L, Kong Y, Bahal R, Geibel JP, Glazer PM, Saltzman WM, Egan ME. Nat Commun. 2015 Apr 27; 2015 Apr 27. PMID: 25914116.", + "Calcium-sensing receptor 20 years later. Alfadda TI, Saleh AM, Houillier P, Geibel JP. Am J Physiol Cell Physiol. 2014 Aug 1; 2014 May 28. PMID: 24871857.", + "A novel device to preserve intestinal tissue ex-vivo by cold peristaltic perfusion. Narayan RR, Pancer NE, Loeb BW, Oki K, Crouch A, Backus S, Chauhan Y, Patrón-Lozano R, Rodriguez-Davalos MI, Geibel JP, Fan RE, Zinter JP. Annu Int Conf IEEE Eng Med Biol Soc. 2014. PMID: 25570651.", + "The putative role of the non-gastric H⁺/K⁺-ATPase ATP12A (ATP1AL1) as anti-apoptotic ion transporter: effect of the H⁺/K⁺ ATPase inhibitor SCH28080 on butyrate-stimulated myelomonocytic HL-60 cells. Jakab M, Hofer S, Ravasio A, Huber F, Schmidt S, Hitzl W, Geibel JP, Fürst J, Ritter M. Cell Physiol Biochem. 2014; 2014 Oct 9. PMID: 25322912.", + "Functional vacuolar ATPase (V-ATPase) proton pumps traffic to the enterocyte brush border membrane and require CFTR. Collaco AM, Geibel P, Lee BS, Geibel JP, Ameen NA. Am J Physiol Cell Physiol. 2013 Nov 1; 2013 Aug 28. PMID: 23986201.", + "Effect of NSAIDs on Na⁺/H⁺ exchanger activity in rat colonic crypts. Roginiel AC, Kohut DL, Kaur S, Saleh AM, Weber T, Geibel P, Singh H, Geibel JP. Am J Physiol Cell Physiol. 2013 Sep; 2013 Jun 5. PMID: 23739181.", + "The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule. Capasso G, Geibel PJ, Damiano S, Jaeger P, Richards WG, Geibel JP. Kidney Int. 2013 Aug; 2013 Apr 24. PMID: 23615500.", + "Activation of AMPK inhibits cholera toxin stimulated chloride secretion in human and murine intestine. Rogers AC, Huetter L, Hoekstra N, Collins D, Collaco A, Baird AW, Winter DC, Ameen N, Geibel JP, Kopic S. PLoS One. 2013; 2013 Jul 30. PMID: 23935921.", + "Identification of functionally distinct Na-HCO3 co-transporters in colon. Barmeyer C, Ye JH, Soroka C, Geibel P, Hingsammer LM, Weitgasser L, Atway D, Geibel JP, Binder HJ, Rajendran VM. PLoS One. 2013; 2013 May 14. PMID: 23690961.", + "Gastric acid, calcium absorption, and their impact on bone health. Kopic S, Geibel JP. Physiol Rev. 2013 Jan. PMID: 23303909.", + "Vacuolar-type H+-ATPase-mediated proton transport in the rat parietal cell. Kopic S, Wagner ME, Griessenauer C, Socrates T, Ritter M, Geibel JP. Pflugers Arch. 2012 Mar; 2011 Nov 17. PMID: 22146938.", + "Functional role of NHE4 as a pH regulator in rat and human colonic crypts. Arena EA, Longo WE, Roberts KE, Geibel P, Nateqi J, Brandstetter M, Geibel JP. Am J Physiol Cell Physiol. 2012 Jan 15; 2011 Nov 2. PMID: 22049213.", + "Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions. Langelueddecke C, Jakab M, Ketterl N, Lehner L, Hufnagl C, Schmidt S, Geibel JP, Fuerst J, Ritter M. Cell Physiol Biochem. 2012; 2012 Mar 1. PMID: 22415077.", + "Hypoxia inhibits colonic ion transport via activation of AMP kinase. Collins D, Kopic S, Bachlechner J, Ritter M, Winter DC, Geibel JP. Ann Surg. 2011 Dec. PMID: 21562404.", + "Calcium-modulated chloride pathways contribute to chloride flux in murine cystic fibrosis-affected macrophages. Shenoy A, Kopic S, Murek M, Caputo C, Geibel JP, Egan ME. Pediatr Res. 2011 Nov. PMID: 21796019.", + "The flavonone naringenin inhibits chloride secretion in isolated colonic epithelia. Collins D, Kopic S, Geibel JP, Hogan AM, Medani M, Baird AW, Winter DC. Eur J Pharmacol. 2011 Oct 1; 2011 Jul 8. PMID: 21762688.", + "Angiotensin II stimulates H⁺-ATPase activity in intercalated cells from isolated mouse connecting tubules and cortical collecting ducts. Wagner CA, Mohebbi N, Uhlig U, Giebisch GH, Breton S, Brown D, Geibel JP. Cell Physiol Biochem. 2011; 2011 Nov 18. PMID: 22116365.", + "The anion exchanger pendrin (SLC26A4) and renal acid-base homeostasis. Wagner CA, Mohebbi N, Capasso G, Geibel JP. Cell Physiol Biochem. 2011; 2011 Nov 18. PMID: 22116363.", + "Zinc salts provide a novel, prolonged and rapid inhibition of gastric acid secretion. Kirchhoff P, Socrates T, Sidani S, Duffy A, Breidthardt T, Grob C, Viehl CT, Beglinger C, Oertli D, Geibel JP. Am J Gastroenterol. 2011 Jan; 2010 Aug 24. PMID: 20736941.", + "Update on the mechanisms of gastric acid secretion. Kopic S, Geibel JP. Curr Gastroenterol Rep. 2010 Dec. PMID: 20821079.", + "The calcium-sensing receptor. Geibel JP. J Nephrol. 2010 Nov-Dec. PMID: 21170870.", + "Toxin mediated diarrhea in the 21 century: the pathophysiology of intestinal ion transport in the course of ETEC, V. cholerae and rotavirus infection. Kopic S, Geibel JP. Toxins (Basel). 2010 Aug; 2010 Aug 10. PMID: 22069677.", + "Commentary on 'Diarrhoeal disease through enterocyte secretion: a doctrine untroubled by proof'. Kopic S, Murek M, Geibel JP. Exp Physiol. 2010 Apr. PMID: 20233894.", + "Ethanol inhibits gastric acid secretion in rats through increased AMP-kinase activity. Kopic S, Corradini S, Sidani S, Murek M, Vardanyan A, Föller M, Ritter M, Geibel JP. Cell Physiol Biochem. 2010; 2010 Jan 12. PMID: 20110680.", + "Revisiting the parietal cell. Kopic S, Murek M, Geibel JP. Am J Physiol Cell Physiol. 2010 Jan; 2009 Nov 4. PMID: 19889964.", + "AMP-activated protein kinase: a physiological off switch for murine gastric acid secretion. Sidani S, Kopic S, Socrates T, Kirchhoff P, Föller M, Murek M, Capasso A, Geibel JP. Pflugers Arch. 2009 Nov; 2009 Jul 21. PMID: 19621238.", + "The functions and roles of the extracellular Ca2+-sensing receptor along the gastrointestinal tract. Geibel JP, Hebert SC. Annu Rev Physiol. 2009. PMID: 19575679.", + "The phytostilbene resveratrol induces apoptosis in INS-1E rat insulinoma cells. Bortolotti C, Kunit T, Moder A, Hufnagl C, Schmidt S, Hartl A, Langelueddecke C, Fürst J, Geibel JP, Ritter M, Jakab M. Cell Physiol Biochem. 2009; 2009 May 6. PMID: 19471092.", + "Mouse model of type II Bartter's syndrome. II. Altered expression of renal sodium- and water-transporting proteins. Wagner CA, Loffing-Cueni D, Yan Q, Schulz N, Fakitsas P, Carrel M, Wang T, Verrey F, Geibel JP, Giebisch G, Hebert SC, Loffing J. Am J Physiol Renal Physiol. 2008 Jun; 2008 Mar 5. PMID: 18322017.", + "SLC26A7 can function as a chloride-loading mechanism in parietal cells. Kosiek O, Busque SM, Föller M, Shcheynikov N, Kirchhoff P, Bleich M, Muallem S, Geibel JP. Pflugers Arch. 2007 Sep; 2007 Apr 3. PMID: 17404755.", + "DeltaF508 mutation results in impaired gastric acid secretion. Sidani SM, Kirchhoff P, Socrates T, Stelter L, Ferreira E, Caputo C, Roberts KE, Bell RL, Egan ME, Geibel JP. J Biol Chem. 2007 Mar 2; 2006 Dec 18. PMID: 17178714.", + "PI3 kinase dependent stimulation of gastric acid secretion by dexamethasone. Lang PA, Schniepp R, Kirchhoff P, Socrates T, Sidani SM, Geibel JP. Cell Physiol Biochem. 2007. PMID: 17762179.", + "Stimulatory pathways of the Calcium-sensing receptor on acid secretion in freshly isolated human gastric glands. Remy C, Kirchhoff P, Hafner P, Busque SM, Müeller MK, Geibel JP, Wagner CA. Cell Physiol Biochem. 2007. PMID: 17310098.", + "Characteristics of the K+-competitive H+,K+-ATPase inhibitor AZD0865 in isolated rat gastric glands. Kirchhoff P, Andersson K, Socrates T, Sidani S, Kosiek O, Geibel JP. Am J Physiol Gastrointest Liver Physiol. 2006 Nov; 2006 Jun 22. PMID: 16798725.", + "The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion. Roepke TK, Anantharam A, Kirchhoff P, Busque SM, Young JB, Geibel JP, Lerner DJ, Abbott GW. J Biol Chem. 2006 Aug 18; 2006 Jun 5. PMID: 16754665.", + "Role of calcium and other trace elements in the gastrointestinal physiology. Kirchhoff P, Geibel JP. World J Gastroenterol. 2006 May 28. PMID: 16718844.", + "Hypertonic saline attenuates colonic tumor cell metastatic potential by activating transmembrane sodium conductance. Shields CJ, Winter DC, Geibel JP, O'Sullivan GC, Wang JH, Redmond HP. J Membr Biol. 2006 May; 2006 Sep 18. PMID: 16988862.", + "Distal tubule acidification. Geibel JP. J Nephrol. 2006 Mar-Apr. PMID: 16736436.", + "An amino acid transporter involved in gastric acid secretion. Kirchhoff P, Dave MH, Remy C, Kosiek O, Busque SM, Dufner M, Geibel JP, Verrey F, Wagner CA. Pflugers Arch. 2006 Mar; 2005 Nov 25. PMID: 16308696.", + "An update on acid secretion. Geibel JP, Wagner C. Rev Physiol Biochem Pharmacol. 2006. PMID: 16634146.", + "The calcium-sensing receptor acts as a modulator of gastric acid secretion in freshly isolated human gastric glands. Dufner MM, Kirchhoff P, Remy C, Hafner P, Müller MK, Cheng SX, Tang LQ, Hebert SC, Geibel JP, Wagner CA. Am J Physiol Gastrointest Liver Physiol. 2005 Dec; 2005 Aug 18. PMID: 16109841.", + "L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells. Busque SM, Kerstetter JE, Geibel JP, Insogna K. Am J Physiol Gastrointest Liver Physiol. 2005 Oct; 2005 Jun 16. PMID: 15961860.", + "The B1-subunit of the H(+) ATPase is required for maximal urinary acidification. Finberg KE, Wagner CA, Bailey MA, Paunescu TG, Breton S, Brown D, Giebisch G, Geibel JP, Lifton RP. Proc Natl Acad Sci U S A. 2005 Sep 20; 2005 Sep 8. PMID: 16174750.", + "Role of potassium in acid secretion. Geibel JP. World J Gastroenterol. 2005 Sep 14. PMID: 16149129.", + "Bicarbonate secretion: a neglected aspect of colonic ion transport. Binder HJ, Rajendran V, Sadasivan V, Geibel JP. J Clin Gastroenterol. 2005 Apr. PMID: 15758660.", + "Fluorescent imaging of Cl- in Amphiuma red blood cells: how the nuclear exclusion of Cl- affects the plasma membrane potential. Hoffman JF, Geibel JP. Proc Natl Acad Sci U S A. 2005 Jan 18; 2005 Jan 6. PMID: 15637151.", + "Secretion and absorption by colonic crypts. Geibel JP. Annu Rev Physiol. 2005. PMID: 15709966.", + "Insulin receptor (IR) and glucose transporter 2 (GLUT2) proteins form a complex on the rat hepatocyte membrane. Eisenberg ML, Maker AV, Slezak LA, Nathan JD, Sritharan KC, Jena BP, Geibel JP, Andersen DK. Cell Physiol Biochem. 2005. PMID: 15665515.", + "Renal vacuolar H+-ATPase. Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP. Physiol Rev. 2004 Oct. PMID: 15383652.", + "Nongenomic stimulation of vacuolar H+-ATPases in intercalated renal tubule cells by aldosterone. Winter C, Schulz N, Giebisch G, Geibel JP, Wagner CA. Proc Natl Acad Sci U S A. 2004 Feb 24. PMID: 14983061.", + "Extracellular polyamines regulate fluid secretion in rat colonic crypts via the extracellular calcium-sensing receptor. Cheng SX, Geibel JP, Hebert SC. Gastroenterology. 2004 Jan. PMID: 14699496.", + "Localization and regulation of the ATP6V0A4 (a4) vacuolar H+-ATPase subunit defective in an inherited form of distal renal tubular acidosis. Stehberger PA, Schulz N, Finberg KE, Karet FE, Giebisch G, Lifton RP, Geibel JP, Wagner CA. J Am Soc Nephrol. 2003 Dec. PMID: 14638902.", + "Demonstration of a functional apical sodium hydrogen exchanger in isolated rat gastric glands. Kirchhoff P, Wagner CA, Gaetzschmann F, Radebold K, Geibel JP. Am J Physiol Gastrointest Liver Physiol. 2003 Dec; 2003 Aug 7. PMID: 12907430.", + "Molecular cloning and characterization of Atp6v1b1, the murine vacuolar H+ -ATPase B1-subunit. Finberg KE, Wagner CA, Stehberger PA, Geibel JP, Lifton RP. Gene. 2003 Oct 30. PMID: 14585495.", + "A rapid enzymatic method for the isolation of defined kidney tubule fragments from mouse. Wagner CA, Lükewille U, Valles P, Breton S, Brown D, Giebisch GH, Geibel JP. Pflugers Arch. 2003 Aug; 2003 May 13. PMID: 12748863.", + "Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base status. Wagner CA, Finberg KE, Stehberger PA, Lifton RP, Giebisch GH, Aronson PS, Geibel JP. Kidney Int. 2002 Dec. PMID: 12427135.", + "Expression of calcium-sensing receptor in rat colonic epithelium: evidence for modulation of fluid secretion. Cheng SX, Okuda M, Hall AE, Geibel JP, Hebert SC. Am J Physiol Gastrointest Liver Physiol. 2002 Jul. PMID: 12065312.", + "Cloning and expression of a chloride-dependent Na+-H+ exchanger. Sangan P, Rajendran VM, Geibel JP, Binder HJ. J Biol Chem. 2002 Mar 22; 2001 Dec 28. PMID: 11773056.", + "Microscopy as a tool for renal research. Geibel JP. J Nephrol. 2002 Mar-Apr. PMID: 12027215.", + "Acid-base transport in the collecting duct. Wagner CA, Geibel JP. J Nephrol. 2002 Mar-Apr. PMID: 12027210.", + "The stomach divalent ion-sensing receptor scar is a modulator of gastric acid secretion. Geibel JP, Wagner CA, Caroppo R, Qureshi I, Gloeckner J, Manuelidis L, Kirchhoff P, Radebold K. J Biol Chem. 2001 Oct 26; 2001 Aug 15. PMID: 11507103.", + "Gap junctional channels regulate acid secretion in the mammalian gastric gland. Radebold K, Horakova E, Gloeckner J, Ortega G, Spray DC, Vieweger H, Siebert K, Manuelidis L, Geibel JP. J Membr Biol. 2001 Oct 1. PMID: 11696856.", + "Impaired hepatocyte glucose transport protein (GLUT2) internalization in chronic pancreatitis. Nathan JD, Zdankiewicz PD, Wang J, Spector SA, Aspelund G, Jena BP, Seymour NE, Geibel JP, Andersen DK. Pancreas. 2001 Mar. PMID: 11249072.", + "Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis. Wagner CA, Ott M, Klingel K, Beck S, Melzig J, Friedrich B, Wild KN, Bröer S, Moschen I, Albers A, Waldegger S, Tümmler B, Egan ME, Geibel JP, Kandolf R, Lang F. Cell Physiol Biochem. 2001. PMID: 11509829.", + "Na(+)-dependent fluid absorption in intact perfused rat colonic crypts. Geibel JP, Rajendran VM, Binder HJ. Gastroenterology. 2001 Jan. PMID: 11208723.", + "Cell pH and H(+) secretion by S3 segment of mammalian kidney: role of H(+)-ATPase and Cl(-). Malnic G, Geibel JP. J Membr Biol. 2000 Nov 15. PMID: 11083900.", + "Dendrimer-assisted patch-clamp sizing of nuclear pores. Bustamante JO, Michelette ER, Geibel JP, Hanover JA, McDonnell TJ, Dean DA. Pflugers Arch. 2000 Apr. PMID: 10784359.", + "Calcium, ATP and nuclear pore channel gating. Bustamante JO, Michelette ER, Geibel JP, Dean DA, Hanover JA, McDonnell TJ. Pflugers Arch. 2000 Feb. PMID: 10678739.", + "Cl-dependent Na-H exchange. A novel colonic crypt transport mechanism. Binder HJ, Rajendran VM, Geibel JP. Ann N Y Acad Sci. 2000. PMID: 11193600.", + "HCO(3)(-) secretion in the rat colonic crypt is closely linked to Cl(-) secretion. Geibel JP, Singh S, Rajendran VM, Binder HJ. Gastroenterology. 2000 Jan. PMID: 10611158.", + "Continuous detection of extracellular ATP on living cells by using atomic force microscopy. Schneider SW, Egan ME, Jena BP, Guggino WB, Oberleithner H, Geibel JP. Proc Natl Acad Sci U S A. 1999 Oct 12. PMID: 10518596.", + "Rapid effects of aldosterone on sodium-hydrogen exchange in isolated colonic crypts. Winter DC, Schneider MF, O'Sullivan GC, Harvey BJ, Geibel JP. J Membr Biol. 1999 Jul 1. PMID: 10398757.", + "Direct effects of dopamine on colonic mucosal pH: implications for tonometry. Winter DC, O'sullivan GC, Harvey BJ, Geibel JP. J Surg Res. 1999 May 1. PMID: 10210644.", + "Expression of an extracellular calcium-sensing receptor in rat stomach. Cheng I, Qureshi I, Chattopadhyay N, Qureshi A, Butters RR, Hall AE, Cima RR, Rogers KV, Hebert SC, Geibel JP, Brown EM, Soybel DI. Gastroenterology. 1999 Jan. PMID: 9869609.", + "Angiotensin II stimulates vesicular H+-ATPase in rat proximal tubular cells. Wagner CA, Giebisch G, Lang F, Geibel JP. Proc Natl Acad Sci U S A. 1998 Aug 4. PMID: 9689138.", + "Atomic force microscopy on living cells: aldosterone-induced localized cell swelling. Schneider SW, Pagel P, Storck J, Yano Y, Sumpio BE, Geibel JP, Oberleithner H. Kidney Blood Press Res. 1998. PMID: 9762848.", + "Brady Memorial Laboratory 310 Cedar Street New Haven, CT 06520-8023 Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Gelernter Lab", + "lab_url": "https://medicine.yale.edu/lab/gelernter/", + "research_bio": "INFORMATION FOR Mental health problems are hugely consequential on an individual and on a societal basis. To understand psychiatric traits better, we need to improve our understanding of the underlying biology. Learning about genetics is a great way to do this, and there has been rapid progress in the study of the genetics of complex psychiatric traits. Our lab is researching this problem from numerous perspectives. We focus on a range of psychiatric traits – stress- and trauma-related traits like posttraumatic stress disorder (PTSD), depression, and anxiety; substance use disorders (SUDs), including alcohol traits, cannabis use disorder, and use of opioids and stimulants; and other SUDs and psychiatric traits. We also study medical traits – for example, the ophthalmologic trait of epiretinal membrane (macular pucker). We use data from samples we have collected over decades of research in the US and Thailand; and biobank samples, especially the US Department of Veterans Affairs Million Veteran Program, and also data from other large biobanks. These data are used to perform genome-wide association studies (GWAS) to identify genetic variants that affect risk for traits of interest; and sequence-based and epigenetic analyses. We also perform post-GWAS analyses, which is critical to understanding biology. With this increased biological understanding, we work to identify potential therapeutic targets that will eventually lead to new treatments and new hope for the patients experiencing these mental health issues. We are active collaborators in the Psychiatric Genomics Consortium (PGC), where Dr Gelernter co-leads the Substance Use Disorder Working Group and participates in numerous other working groups. We lead ongoing NIH-funded projects based in the US and in Thailand, and receive funding from the National Institutes of Health (NIMH, NIDA, and NIAAA) and the United States Department of Veterans Affairs. Please feel free to contact Dr. Gelernter,joel.gelernter@yale.edu, or any lab member, to discuss further, as we are always interested in working with talented people and welcome inquiries from people interested in joining our lab. Dr Gelernter leads the Division of Human Genetics in Psychiatry at Yale; besides his own lab the Division includes labs led by Dr Renato Polimanti, Dr Janitza Montalvo-Ortiz, Dr. Daniel Levey, and Dr Hang Zhou (all of whom are Gelernter Lab Alumni). Within the Division there are extensive ongoing research collaborations between all of our labs. We also collaborate widely with other groups at Yale and elsewhere, most notably with Dr Murray Stein at UC San Diego and other MVP investigators; many other PGC investigators, as mentioned above; Drs Rasmon Kalayasiri and Apiwat Mutirangura at Chulalongkorn Faculty of Medicine (Bangkok), and Dr Henry Kranzler at the University of Pennsylvania.", + "publications_page": "https://medicine.yale.edu/lab/gelernter/publications/", + "publications": [ + "Yale School of Medicine /", + "Research & Projects", + "News", + "Summary Statistics", + "Additional Materials", + "Lab Members", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research & Projects", + "Summary Statistics", + "Lab Members", + "Publications", + "News", + "Additional Materials", + "", + "", + "", + "", + "", + "", + "Developmental timing of index trauma exposure and accelerated epigenetic aging in United States military veterans. Tamman AJF, Nagamatsu ST, Cabrera-Mendoza B, Averill LA, Dunn EC, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Polimanti R, Pietrzak RH. Psychoneuroendocrinology. 2025 Dec; 2025 Sep 17. PMID: 41016323.", + "Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group. Colbert SMC, Monson ET, Andreassen OA, Ayinde OO, Barr PB, Bejan CA, Ceja Z, Coon H, DiBlasi E, Edenberg HJ, Gelernter J, Hatoum A, Izotova A, Johnson EC, Kaufman EA, Kranzler HR, Koromina M, Lehto K, Myung W, Nurnberger JI Jr, Serretti A, Smoller JW, Stein MB, Zai CC, Erlangsen A, Gaine M, Martorell L, Sud R, Toma C, Bigdeli TB, Kimbrel NA, Ruderfer D, Docherty AR, Mann JJ, Mullins N. Mol Psychiatry. 2025 Dec; 2025 Sep 25. PMID: 40999039.", + "Environmental, Psychiatric, and Genetic Predictors of Alcohol Use Disorder Criterion Count: Analyses of African and European Ancestries. Na PJ, Deak JD, Levey DF, Kember RL, Kranzler HR, Pietrzak RH, Gelernter J. Am J Psychiatry. 2025 Nov 1; 2025 Sep 24. PMID: 40988466.", + "Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants. Wang L, Nuñez YZ, Martínez-Magaña JJ, Rivera-Hernandez M, Mao Z, Brennand KJ, Montalvo-Ortiz JL, Kranzler HR, Gelernter J, Zhou H. Transl Psychiatry. 2025 Oct 6; 2025 Oct 6. PMID: 41052974.", + "The genetics of cannabis lifetime use. Bright U, Beck S, Galimberti M, Gupta P, Chen Y, Dao C, Nunez YZ, Kranzler HR, Zhou Y, Zhang Y, Choi KW, Levey DF, Gelernter J. Neuropsychopharmacology. 2025 Oct 3; 2025 Oct 3. PMID: 41044382.", + "Measures of General Intelligence and Risk for Alcohol Use Disorder. Capusan AJ, Davis CN, Thern E, Rehm J, Gelernter J, Kranzler HR, Heilig M. JAMA Psychiatry. 2025 Oct 1; 2025 Oct 1. PMID: 41032335.", + "Genotype-by-sex interaction analyses for alcohol use disorder across biobanks. Zhou H, Wang L, Mao Z, Deans PJM, Kember RL, Chen Q, Zakiniaeiz Y, Kohler R, Peltier MR, Verplaetse TL, Potenza MN, Brennand KJ, Justice AC, Kranzler HR, Gelernter J, McKee SA. Alcohol Clin Exp Res (Hoboken). 2025 Sep 29; 2025 Sep 29. PMID: 41017299.", + "Alcohol use and risk of dementia in diverse populations: evidence from cohort, case-control and Mendelian randomisation approaches. Topiwala A, Levey DF, Zhou H, Deak JD, Adhikari K, Ebmeier KP, Bell S, Burgess S, Nichols TE, Gaziano M, Stein M, Gelernter J. BMJ Evid Based Med. 2025 Sep 23; 2025 Sep 23. PMID: 40987604.", + "A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies. Huang YJ, Kurniansyah N, Levey DF, Gelernter J, Huffman JE, Cho K, Wilson PWF, Gottlieb DJ, Rice KM, Sofer T. Am J Hum Genet. 2025 Sep 4. PMID: 40912238.", + "DNA Methylation Signatures of Alcohol Use Disorder - A large-scale Meta-Analysis in the Psychiatric Genomics Consortium. Zillich L, D'Augello S, Avetyan D, Delgado GE, Gizer IR, Jung J, Katrinli S, Kleber ME, Merrill N, Moissl AP, Núñez-Rios DL, Otto JM, Zillich E, Friedel E, Hancock DB, Johnson EO, Martínez-Magaña JJ, Nagamatsu ST, Sosnowski DW, White JD, Aberg KA, Copeland WE, Diazgranados N, Fani N, Gelernter J, Goldman D, Foo JC, Kranzler HR, Levey DF, März W, Penninx BWJH, Polimanti R, Powers A, Smith AK, Spanagel R, van den Oord EJCG, Wilhelmsen KC, Witt SH, Domschke K, Schiele MA, Maher BS, Montalvo Ortiz JL, Clark SL, Lohoff FW. medRxiv. 2025 Sep 2; 2025 Sep 2. PMID: 40950452.", + "Genetics of SSRI antidepressant use and relationship to psychiatric and medical traits. Levey D, Galimberti M, Deak J, Gupta P, Empke SLL, Adhikari K, Harrington K, Quaden R, Gaziano JJM, Stein MB, Gelernter J. HGG Adv. 2025 Sep 2; 2025 Sep 2. PMID: 40903904.", + "Predicting treatment-seeking status for alcohol use disorder using polygenic scores and machine learning in a deeply-phenotyped sample. Jinwala Z, Green R, Khan Y, Gelernter J, Kember RL, Hartwell EE. Drug Alcohol Depend. 2025 Sep 1; 2025 Jul 16. PMID: 40695097.", + "Epigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses. Pathak GA, Pietrzak RH, Lacobelle A, Overstreet C, Wendt FR, Deak JD, Friligkou E, Nunez YZ, Montalvo-Ortiz JL, Levey DF, Kranzler HR, Gelernter J, Polimanti R. Mol Psychiatry. 2025 Sep; 2025 Apr 17. PMID: 40247127.", + "Functional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches. Cakir B, Tanaka Y, Choe MS, Chu PY, Xiang Y, Kim KY, Zhong M, Gelernter J, Zhang H, Krystal J, Park IH. Int J Stem Cells. 2025 Aug 30; 2025 Apr 10. PMID: 40205763.", + "Multi-ancestry Genome-wide Association Study of Inpatient Opioid Dosing Following Knee or Hip Arthroplasty. Jinwala Z, Davis CN, SooHoo JF, Gelernter J, Kember RL, Vickers-Smith R, Kranzler HR. Res Sq. 2025 Aug 21; 2025 Aug 21. PMID: 40894051.", + "Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits. Johnson EC, Lai D, Balbona JV, Miller AP, Hatoum AS, Deak JD, Jennings M, Baranger DAA, Galimberti M, Sanichwankul K, Thorgeirsson T, Colbert SMC, Adhikari K, Docherty AR, Degenhardt L, Edwards T, Fox L, Giannelis A, Jeffries PW, Korhonen T, Morrison CL, Nunez YZ, Palviainen T, Su MH, Romero Villela PN, Wetherill L, Willoughby EA, Zellers SM, Bierut LJ, Buchwald J, Copeland WE, Corley RP, Friedman NP, Foroud TM, Gillespie NA, Gizer IR, Heath AC, Hickie IB, Kaprio J, Keller MC, Lee JJ, Lind P, Madden PA, Maes HHM, Martin NG, McGue M, Medland SE, Nelson EC, Pearson J, Porjesz B, Stallings MC, Vrieze S, Wilhelmson KC, Kranzler HR, Walters RK, Polimanti R, Malison R, Zhou H, Stefansson K, Sanchez-Roige S, Potenza M, Mutirangura A, Shotelersuk V, Kalayasiri R, Edenberg HJ, Gelernter J, Agrawal A. Psychol Med. 2025 Aug 20; 2025 Aug 20. PMID: 40831304.", + "A contextual genomic perspective on physical activity and its relationship to health, well being and illness. Galimberti M, Levey DF, Deak JD, Adhikari K, Overstreet C, Gupta P, Nitin R, Zhou H, Lake NJ, Harrington KM, Djousse L, Davis LK, Gaziano JM, Stein MB, Gelernter J. Nat Genet. 2025 Aug; 2025 Jul 21. PMID: 40691405.", + "The Psychiatric Genomics Consortium: discoveries and directions. Agrawal A, Bulik CM, Abebe DS, Andreassen OA, Atkinson EG, Choi KW, Corvin A, Davies HL, Davis LK, Docherty AR, Edenberg HJ, Franke B, Gelernter J, Giusti-Rodríguez P, Hettema JM, Hjerling-Leffler J, Huang H, Johnson EC, Lewis CM, Lu Y, Lynall ME, Martin J, McIntosh AM, Montalvo-Ortiz JL, Mullins N, Nievergelt CM, O'Connell KS, O'Donovan MC, Okewole A, Peterson RE, Posthuma D, Sebat J, Smoller JW, Sud R, Viswanath B, Walters JTR, Won H, Wray NR, Sullivan PF. Lancet Psychiatry. 2025 Aug; 2025 Jun 26. PMID: 40582370.", + "Polygenic risk and childhood adversity as moderators of drug and alcohol withdrawal symptoms. Han A, Davis CN, Jinwala Z, SooHoo J, Gelernter J, Feinn R, Kranzler HR. Drug Alcohol Depend. 2025 Aug 1; 2025 May 14. PMID: 40449208.", + "Multi-ancestry genome-wide association meta-analysis of buprenorphine treatment response. Davis CN, Khan Y, Crist RC, Vickers-Smith R, Hartwell EE, Gelernter J, Kampman K, Kember RL, Le Moigne A, Laffont CM, Kranzler HR. Neuropsychopharmacology. 2025 Aug; 2025 May 6. PMID: 40328918.", + "Cell-type-specific and inflammatory DNA methylation patterns associated with PTSD. Smith AK, Katrinli S, Maihofer AX, Aiello AE, Baker DG, Boks MP, Brick LA, Chen CY, Dalvie S, Fani N, Fortier CB, Gelernter J, Geuze E, Gillespie CF, Hayes JP, Hong S, Kessler RC, King AP, Koen N, Koenen KC, Liberzon I, Linnstaedt SD, McLean SA, Michopoulos V, Milberg WP, Miller MW, Mufford MS, Nugent NR, Orcutt HK, Powers A, Rauch SAM, Ressler KJ, Risbrough VB, Rutten BPF, Smoller JW, Stein DJ, Stein MB, Ursano RJ, Verfaellie MH, Vermetten E, Vinkers CH, Wani AH, WareVinkers EB, Wildman DE, Wolf EJ, Zhao Y, Logue MW, Nievergelt CM, Uddin M, Zannas AS. Brain Behav Immun. 2025 Aug; 2025 Apr 24. PMID: 40286993.", + "Differences and similarities between the genetic architecture of lifetime substance use across different substances. Bright U, Overstreet C, Levey DF, Gelernter J. Psychol Med. 2025 Jul 30; 2025 Jul 30. PMID: 40736093.", + "Multi-ancestry Genome-wide Association Study of Inpatient Opioid Dosing Following Knee or Hip Arthroplasty. Jinwala Z, Davis CN, SooHoo JF, Gelernter J, Kember RL, Vickers-Smith R, Kranzler HR. medRxiv. 2025 Jul 24; 2025 Jul 24. PMID: 40778174.", + "Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses. Shen J, Valentim W, Friligkou E, Overstreet C, Choi KW, Koller D, O'Donnell CJ, Stein MB, Gelernter J, Lv H, Sun L, Falcone GJ, Polimanti R, Pathak GA. Nat Commun. 2025 Jul 1; 2025 Jul 1. PMID: 40595462.", + "Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD. 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PMID: 40501985.", + "Psychometric properties and socio-demographic correlates of the Connor-Davidson Resilience Scale in three large population-based cohorts including Danish and Icelandic adults. Didriksen M, Daníelsdottir H, Bjarnadóttir MD, Overstreet C, Choi KW, Christoffersen LAN, Mikkelsen C, Aspelund T, Hauksdóttir A, Thordardottir EB, Jakobsdóttir J, Tómasson G, Erikstrup C, Aagaard B, Bruun MT, Ullum H, Sørensen E, Fischer IC, Pietrzak RH, Gelernter J, Campbell-Sills L, Stein MB, Werge T, Pedersen OB, Valdimarsdóttir U, Ostrowski SR, Schork AJ. J Mood Anxiety Disord. 2025 Jun; 2025 Feb 17. PMID: 40657597.", + "Moderation of treatment outcomes by polygenic risk for alcohol-related traits in placebo-controlled trials of topiramate. Kranzler HR, Jinwala Z, Davis CN, Xu H, Biernacka JM, Zhou H, Kember RL, Gelernter J, Feinn R. Alcohol Clin Exp Res (Hoboken). 2025 Jun; 2025 May 30. 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Nat Genet. 2025 Jun; 2025 May 13. PMID: 40360802.", + "Optimism moderates the relationship between inflammatory polygenic risk and major depressive disorder in U.S. Military veterans. Fischer IC, Overstreet C, Cabrera-Mendoza B, Qiu D, Krystal JH, Polimanti R, Gelernter J, Pietrzak RH. World J Biol Psychiatry. 2025 Jun; 2025 May 9. PMID: 40343713.", + "A contextual genomic perspective on physical activity and its relationship to health, well-being and illness. Galimberti M, Levey DF, Deak JD, Adhikari K, Overstreet C, Gupta P, Nitin R, Zhou H, Lake NJ, Harrington KM, Djousse L, Davis LK, Gaziano JM, Stein MB, Gelernter J. medRxiv. 2025 May 28; 2025 May 28. PMID: 40321252.", + "Associations of Childhood Adversity and Polygenic Scores with Substance Use Initiation and Disorder Severity - ERRATUM. SooHoo JF, Davis CN, Han A, Jinwala Z, Gelernter J, Feinn R, Kranzler HR. Psychol Med. 2025 May 22; 2025 May 22. PMID: 40400391.", + "Multi-ancestry genetic architecture of sleep duration and its relationship to other sleep and psychiatric phenotypes. Austin-Zimmerman I, Levey DF, Deak JD, Galimberti M, Adhikari K, Coleman JRI, Buysse DJ, Wilson PWF, Sofer T, Gaziano JM, Gottlieb DJ, Stein MB, Forti MD, Gelernter J. medRxiv. 2025 May 21; 2025 May 21. PMID: 40475156.", + "Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality. 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PMID: 40475535.", + "Unraveling the genetics of gulf war illness in diverse participants enrolled in the million veteran program. Pathak GA, Koller D, Cabrera-Mendoza B, Nono Djotsa ABS, Wendt FR, De Lillo A, Friligkou E, He J, Kouakou MR, Duong LM, Vahey J, Steele L, Quaden R, Harrington KM, Ahmed ST, Gaziano JM, Concato J, Zhao H, Radhakrishnan K, Gelernter J, Gifford E, Aslan M, Helmer DA, Hauser ER, Polimanti R. Hum Mol Genet. 2025 May 14; 2025 May 14. PMID: 40366759.", + "PTSD and epigenetic aging: a longitudinal meta-analysis. Zhao X, Katrinli S, McCormick BM, Miller MW, Nugent NR, Wani AH, Zannas AS, Aiello AE, Baker DG, Boks MP, Chen CY, Fortier CB, Gelernter J, Geuze E, Koenen KC, Linnstaedt SD, Luykx JJ, Maihofer AX, McLean SA, Milberg WP, Ratanatharathorn A, Ressler KJ, Risbrough VB, Rutten BPF, Smoller JW, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Ware EB, Wildman DE, Zhao Y, Logue MW, Nievergelt CM, Smith AK, Uddin M, Wolf EJ. Psychol Med. 2025 May 14; 2025 May 14. PMID: 40366073.", + "Integrating HiTOP and RDoC frameworks part II: shared and distinct biological mechanisms of externalizing and internalizing psychopathology. Davis CN, Khan Y, Toikumo S, Jinwala Z, Boomsma DI, Levey DF, Gelernter J, Kember RL, Kranzler HR. Psychol Med. 2025 May 9; 2025 May 9. PMID: 40340892.", + "Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology. Davis CN, Khan Y, Toikumo S, Jinwala Z, Boomsma DI, Levey DF, Gelernter J, Kember RL, Kranzler HR. Psychol Med. 2025 May 8; 2025 May 8. PMID: 40336358.", + "Associations of childhood adversity and substance use disorder polygenic scores with disorder severity and diagnostic criteria. SooHoo JF, Davis CN, Han A, Jinwala Z, Gelernter J, Feinn R, Kranzler HR. Psychol Med. 2025 May 2; 2025 May 2. PMID: 40314172.", + "Psychiatric genetics in the diverse landscape of Latin American populations. 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Nat Genet. 2025 May; 2025 Apr 2. PMID: 40175716.", + "Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations. Malone SG, Davis CN, Piserchia Z, Setzer MR, Toikumo S, Zhou H, Winterlind EL, Gelernter J, Justice A, Leggio L, Rentsch CT, Kranzler HR, Gray JC. Nat Hum Behav. 2025 May; 2025 Mar 31. PMID: 40164914.", + "Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. Strom NI, Gerring ZF, Galimberti M, Yu D, Halvorsen MW, Abdellaoui A, Rodriguez-Fontenla C, Sealock JM, Bigdeli T, Coleman JR, Mahjani B, Thorp JG, Bey K, Burton CL, Luykx JJ, Zai G, Alemany S, Andre C, Askland KD, Bäckmann J, Banaj N, Barlassina C, Nissen JB, Bienvenu OJ, Black D, Bloch MH, Børte S, Bosch R, Breen M, Brennan BP, Brentani H, Buxbaum JD, Bybjerg-Grauholm J, Byrne EM, Cabana-Dominguez J, Camarena B, Camarena A, Cappi C, Carracedo A, Casas M, Cavallini MC, Ciullo V, Cook EH, Crosby J, Cullen BA, De Schipper EJ, Delorme R, Djurovic S, Elias JA, Estivill X, Falkenstein MJ, Fundin BT, Garner L, Gironda C, Goes FS, Grados MA, Grove J, Guo W, Haavik J, Hagen K, Harrington K, Havdahl A, Höffler KD, Hounie AG, Hucks D, Hultman C, Janecka M, Jenike E, Karlsson EK, Kelley K, Klawohn J, Krasnow JE, Krebs K, Lange C, Lanzagorta N, Levey D, Lindblad-Toh K, Macciardi F, Maher B, Mathes B, McArthur E, McGregor N, McLaughlin NC, Meier S, Miguel EC, Mulhern M, Nestadt PS, Nurmi EL, O'Connell KS, Osiecki L, Ousdal OT, Palviainen T, Pedersen NL, Piras F, Piras F, Potluri S, Rabionet R, Ramirez A, Rauch S, Reichenberg A, Riddle MA, Ripke S, Rosário MC, Sampaio AS, Schiele MA, Skogholt AH, Sloofman LG, Smit J, Soler Artigas M, Thomas LF, Tifft E, Vallada H, van Kirk N, Veenstra-VanderWeele J, Vulink NN, Walker CP, Wang Y, Wendland JR, Winsvold BS, Yao Y, Zhou H, Agrawal A, Alonso P, Berberich G, Bucholz KK, Bulik CM, Cath D, Denys D, Eapen V, Edenberg H, Falkai P, Fernandez TV, Fyer AJ, Gaziano JM, Geller DA, Grabe HJ, Greenberg BD, Hanna GL, Hickie IB, Hougaard DM, Kathmann N, Kennedy J, Lai D, Landén M, Le Hellard S, Leboyer M, Lochner C, McCracken JT, Medland SE, Mortensen PB, Neale BM, Nicolini H, Nordentoft M, Pato M, Pato C, Pauls DL, Piacentini J, Pittenger C, Posthuma D, Ramos-Quiroga JA, Rasmussen SA, Richter MA, Rosenberg DR, Ruhrmann S, Samuels JF, Sandin S, Sandor P, Spalletta G, Stein DJ, Stewart SE, Storch EA, Stranger BE, Turiel M, Werge T, Andreassen OA, Børglum AD, Walitza S, Hveem K, Hansen BK, Rück C, Martin NG, Milani L, Mors O, Reichborn-Kjennerud T, Ribasés M, Kvale G, Mataix-Cols D, Domschke K, Grünblatt E, Wagner M, Zwart JA, Breen G, Nestadt G, Kaprio J, Arnold PD, Grice DE, Knowles JA, Ask H, Verweij KJ, Davis LK, Smit DJ, Crowley JJ, Scharf JM, Stein MB, Gelernter J, Mathews CA, Derks EM, Mattheisen M. medRxiv. 2025 Apr 8; 2025 Apr 8. PMID: 38712091.", + "A multicenter cross-sectional study of gambling disorder among patients with methamphetamine use disorder in drug rehabilitation centers: prevalence, correlates, and network analysis. Peng P, Hao Y, Zhang X, Ma Y, Liu X, Shen D, Shen W, Zhao B, Li D, Beck SE, Nunez YZ, Potenza MN, Gelernter J, Liu T, Yang BZ. Ann Gen Psychiatry. 2025 Mar 3; 2025 Mar 3. PMID: 40033412.", + "Integrating HiTOP and RDoC Frameworks Part I: Genetic Architecture of Externalizing and Internalizing Psychopathology. Davis CN, Khan Y, Toikumo S, Jinwala Z, Boomsma DI, Levey DF, Gelernter J, Kember RL, Kranzler HR. medRxiv. 2025 Feb 5; 2025 Feb 5. PMID: 38645045.", + "Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits. 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Hatoum AS, Davis CN, Kember RL, Johnstone M, Oslin DW, Zinkstok JR, Burmeister M, Agrawal A, Kranzler HR, Edenberg HJ, Gelernter J, Docherty AR, Lencz T. Lancet Psychiatry. 2025 Feb; 2024 Oct 13. PMID: 39413801.", + "The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders. Grotzinger AD, Werme J, Peyrot WJ, Frei O, de Leeuw C, Bicks LK, Guo Q, Margolis MP, Coombes BJ, Batzler A, Pazdernik V, Biernacka JM, Andreassen OA, Anttila V, Børglum AD, Cai N, Demontis D, Edenberg HJ, Faraone SV, Franke B, Gandal MJ, Gelernter J, Hettema JM, Jonas KG, Knowles JA, Koenen KC, Maihofer AX, Mallard TT, Mattheisen M, Mitchell KS, Neale BM, Nievergelt CM, Nurnberger JI, O'Connell KS, Robinson EB, Sanchez-Roige SS, Santangelo SL, Stefansson H, Stefansson K, Stein MB, Strom NI, Thornton LM, Tucker-Drob EM, Verhulst B, Waldman ID, Walters GB, Wray NR, Lee PH, Kendler KS, Smoller JW. medRxiv. 2025 Jan 15; 2025 Jan 15. PMID: 40568675.", + "A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies. Huang YJ, Kurniansyah N, Levey DF, Gelernter J, Huffman JE, Cho K, Wilson PWF, Gottlieb DJ, Rice KM, Sofer T. medRxiv. 2025 Jan 2; 2025 Jan 2. PMID: 39802770.", + "Utility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder. Davis CN, Jinwala Z, Hatoum AS, Toikumo S, Agrawal A, Rentsch CT, Edenberg HJ, Baurley JW, Hartwell EE, Crist RC, Gray JC, Justice AC, Gelernter J, Kember RL, Kranzler HR. JAMA Netw Open. 2025 Jan 2; 2025 Jan 2. PMID: 39786773.", + "Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, Kranzler HR, Gelernter J, Harris KM, Tucker-Drob EM, Waldman ID, Palmer AA, Harden KP, Koellinger PD, Dick DM. Nat Neurosci. 2025 Jan. PMID: 39643700.", + "Opioid use disorder and brain health: observational and genetic associations. Javidnia S, Roe JM, Karhunen V, Gill D, Bell S, Deak J, Levey D, Cronje T, Burgess S, Gelernter J, Ebmeier KP, Topiwala A. medRxiv. 2024 Dec 18; 2024 Dec 18. PMID: 39763526.", + "Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations. Malone SG, Davis CN, Piserchia Z, Setzer MR, Toikumo S, Zhou H, Winterlind EL, Gelernter J, Justice A, Leggio L, Rentsch CT, Kranzler HR, Gray JC. medRxiv. 2024 Dec 14; 2024 Dec 14. PMID: 38746260.", + "Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans. Fischer IC, Na PJ, Nagamatsu ST, Jeste DV, Cabrera-Mendoza B, Montalvo-Ortiz JL, Krystal JH, Polimanti R, Gelernter J, Pietrzak RH. JAMA Psychiatry. 2024 Dec 1. PMID: 39476130.", + "Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and somatic traits. Hartwell EE, Jinwala Z, Milone J, Ramirez S, Gelernter J, Kranzler HR, Kember RL. Neuropsychopharmacology. 2024 Dec; 2024 Jul 23. PMID: 39043921.", + "Predicting Treatment-seeking Status for Alcohol Use Disorder Using Polygenic Scores and Machine Learning in a Deeply-Phenotyped Sample. Jinwala Z, Green R, Khan Y, Gelernter J, Kember RL, Hartwell EE. medRxiv. 2024 Nov 23; 2024 Nov 23. PMID: 39606347.", + "Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction. Braun A, Shekhar S, Levey DF, Straub P, Kraft J, Panagiotaropoulou GM, Heilbron K, Awasthi S, Meleka Hanna R, Hoffmann S, Stein M, Lehnerer S, Mergenthaler P, Elnahas AG, Topaloudi A, Koromina M, Palviainen T, Asbjornsdottir B, Stefansson H, Skuladóttir AT, Jónsdóttir I, Stefansson K, Reis K, Esko T, Palotie A, Leypoldt F, Stein MB, Fontanillas P, Kaprio J, Gelernter J, Davis LK, Paschou P, Tannemaat MR, Verschuuren JJGM, Kuhlenbäumer G, Gregersen PK, Huijbers MG, Stascheit F, Meisel A, Ripke S. Nat Commun. 2024 Nov 13; 2024 Nov 13. PMID: 39537604.", + "What Are the Genetic Building Blocks of Alcohol-Related Behaviors? Gelernter J, Deak JD. Am J Psychiatry. 2024 Nov 1. PMID: 39482951.", + "A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. Gupta P, Galimberti M, Liu Y, Beck S, Wingo A, Wingo T, Adhikari K, Kranzler HR, Stein MB, Gelernter J, Levey DF. Nat Hum Behav. 2024 Nov; 2024 Aug 12. PMID: 39134740.", + "Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study. Ishrat S, Levey DF, Gelernter J, Ebmeier K, Topiwala A. BMJ Ment Health. 2024 Oct 30; 2024 Oct 30. PMID: 39477366.", + "Epigenetic and Genetic Profiling of Comorbidity Patterns among Substance Dependence Diagnoses. Pathak GA, Pietrzak RH, Lacobelle A, Overstreet C, Wendt FR, Deak JD, Friligkou E, Nunez Y, Montalvo-Ortiz JL, Levey DF, Kranzler HR, Gelernter J, Polimanti R. medRxiv. 2024 Oct 8; 2024 Oct 8. PMID: 39417130.", + "Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking. Johnson EC, Austin-Zimmerman I, Thorpe HHA, Levey DF, Baranger DAA, Colbert SMC, Demontis D, Khokhar JY, Davis LK, Edenberg HJ, Di Forti M, Sanchez-Roige S, Gelernter J, Agrawal A. Neuropsychopharmacology. 2024 Oct; 2024 Jun 21. PMID: 38906991.", + "Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants. Wang L, Nuñez YZ, Kranzler HR, Zhou H, Gelernter J. medRxiv. 2024 Sep 17; 2024 Sep 17. PMID: 39371181.", + "Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits. Galimberti M, Levey DF, Deak JD, Zhou H, Stein MB, Gelernter J. Mol Psychiatry. 2024 Sep; 2024 Apr 5. PMID: 38580809.", + "Association patterns of antisocial personality disorder across substance use disorders. Low A, Stiltner B, Nunez YZ, Adhikari K, Deak JD, Pietrzak RH, Kranzler HR, Gelernter J, Polimanti R. Transl Psychiatry. 2024 Aug 28; 2024 Aug 28. PMID: 39198385.", + "Genetics of posttraumatic stress disorder and cardiovascular conditions using Life's Essential 8, Electronic Health Records, and Heart Imaging. Shen J, Valentim W, Friligkou E, Overstreet C, Choi K, Koller D, O'Donnell CJ, Stein MB, Gelernter J, Lv H, Sun L, Falcone GJ, Polimanti R, Pathak GA. medRxiv. 2024 Aug 21; 2024 Aug 21. PMID: 39228734.", + "Human genetics and epigenetics of alcohol use disorder. Zhou H, Gelernter J. J Clin Invest. 2024 Aug 15; 2024 Aug 15. PMID: 39145449.", + "Gene × environment effects and mediation involving adverse childhood events, mood and anxiety disorders, and substance dependence. Kranzler HR, Davis CN, Feinn R, Jinwala Z, Khan Y, Oikonomou A, Silva-Lopez D, Burton I, Dixon M, Milone J, Ramirez S, Shifman N, Levey D, Gelernter J, Hartwell EE, Kember RL. Nat Hum Behav. 2024 Aug; 2024 Jun 4. PMID: 38834750.", + "Multivariate, Multi-omic Analysis in 799,429 Individuals Identifies 134 Loci Associated with Somatoform Traits. Davis CN, Toikumo S, Hatoum AS, Khan Y, Pham BK, Pakala SR, Feuer KL, Gelernter J, Sanchez-Roige S, Kember RL, Kranzler HR. medRxiv. 2024 Jul 29; 2024 Jul 29. PMID: 39132487.", + "Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F, Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP. Science. 2024 Jul 19; 2024 Jul 19. PMID: 39024449.", + "Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling. Strom NI, Verhulst B, Bacanu SA, Cheesman R, Purves KL, Gedik H, Mitchell BL, Kwong AS, Faucon AB, Singh K, Medland S, Colodro-Conde L, Krebs K, Hoffmann P, Herms S, Gehlen J, Ripke S, Awasthi S, Palviainen T, Tasanko EM, Peterson RE, Adkins DE, Shabalin AA, Adams MJ, Iveson MH, Campbell A, Thomas LF, Winsvold BS, Drange OK, Børte S, Ter Kuile AR, Nguyen TH, Meier SM, Corfield EC, Hannigan L, Levey DF, Czamara D, Weber H, Choi KW, Pistis G, Couvy-Duchesne B, Van der Auwera S, Teumer A, Karlsson R, Garcia-Argibay M, Lee D, Wang R, Bjerkeset O, Stordal E, Bäckmann J, Salum GA, Zai CC, Kennedy JL, Zai G, Tiwari AK, Heilmann-Heimbach S, Schmidt B, Kaprio J, Kennedy MM, Boden J, Havdahl A, Middeldorp CM, Lopes FL, Akula N, McMahon FJ, Binder EB, Fehm L, Ströhle A, Castelao E, Tiemeier H, Stein DJ, Whiteman D, Olsen C, Fuller Z, Wang X, Wray NR, Byrne EM, Lewis G, Timpson NJ, Davis LK, Hickie IB, Gillespie NA, Milani L, Schumacher J, Woldbye DP, Forstner AJ, Nöthen MM, Hovatta I, Horwood J, Copeland WE, Maes HH, McIntosh AM, Andreassen OA, Zwart JA, Mors O, Børglum AD, Mortensen PB, Ask H, Reichborn-Kjennerud T, Najman JM, Stein MB, Gelernter J, Milaneschi Y, Penninx BW, Boomsma DI, Maron E, Erhardt-Lehmann A, Rück C, Kircher TT, Melzig CA, Alpers GW, Arolt V, Domschke K, Smoller JW, Preisig M, Martin NG, Lupton MK, Luik AI, Reif A, Grabe HJ, Larsson H, Magnusson PK, Oldehinkel AJ, Hartman CA, Breen G, Docherty AR, Coon H, Conrad R, Lehto K, Deckert J, Eley TC, Mattheisen M, Hettema JM. medRxiv. 2024 Jul 5; 2024 Jul 5. PMID: 39006447.", + "Identifying neurofunctional domains across substance use disorders. Hartwell EE, Schwandt M, Nunez YZ, Wetherill RR, Kember RL, Wiers CE, Gelernter J, Kranzler HR. Am J Drug Alcohol Abuse. 2024 Jul 3; 2024 Jul 17. PMID: 39018668.", + "Distinguishing vulnerability and resilience to posttraumatic stress disorder evaluating traumatic experiences, genetic risk and electronic health records. Løkhammer S, Koller D, Wendt FR, Choi KW, He J, Friligkou E, Overstreet C, Gelernter J, Hellard SL, Polimanti R. Psychiatry Res. 2024 Jul; 2024 May 8. PMID: 38744179.", + "Author Correction: A multi-ancestry genetic study of pain intensity in 598,339 veterans. Toikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell EE, Pavicic M, Sullivan KA, Xu K, Jacobson DA, Gelernter J, Rentsch CT, Stahl E, Cheatle M, Zhou H, Waxman SG, Justice AC, Kember RL, Kranzler HR. Nat Med. 2024 Jul. PMID: 38714900.", + "Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders. Koller D, Friligkou E, Stiltner B, Pathak GA, Løkhammer S, Levey DF, Zhou H, Hatoum AS, Deak JD, Kember RL, Treur JL, Kranzler HR, Johnson EC, Stein MB, Gelernter J, Polimanti R. Mol Psychiatry. 2024 Jul; 2024 Feb 15. PMID: 38355787.", + "Genome-wide association study of the common retinal disorder epiretinal membrane: Significant risk loci in each of three American populations. Gelernter J, Levey DF, Galimberti M, Harrington K, Zhou H, Adhikari K, Gupta P, Gaziano JM, Eliott D, Stein MB. Cell Genom. 2024 Jun 12. PMID: 38870908.", + "Polygenic liability for anxiety in association with comorbid anxiety in multiple sclerosis. Kowalec K, Harder A, Dolovich C, Fitzgerald KC, Salter A, Lu Y, Bernstein CN, Bolton JM, Cutter G, Fisk JD, Gelernter J, Graff LA, Hägg S, Hitchon CA, Levey DF, Lublin FD, McKay KA, Patten S, Patki A, Stein MB, Tiwari HK, Wolinsky JS, Marrie RA. Ann Clin Transl Neurol. 2024 Jun; 2024 May 7. PMID: 38715244.", + "Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes. Toikumo S, Jennings MV, Pham BK, Lee H, Mallard TT, Bianchi SB, Meredith JJ, Vilar-Ribó L, Xu H, Hatoum AS, Johnson EC, Pazdernik VK, Jinwala Z, Pakala SR, Leger BS, Niarchou M, Ehinmowo M, Jenkins GD, Batzler A, Pendegraft R, Palmer AA, Zhou H, Biernacka JM, Coombes BJ, Gelernter J, Xu K, Hancock DB, Cox NJ, Smoller JW, Davis LK, Justice AC, Kranzler HR, Kember RL, Sanchez-Roige S. Nat Hum Behav. 2024 Jun; 2024 Apr 17. PMID: 38632388.", + "Genetic and non-genetic predictors of risk for opioid dependence. Na PJ, Deak JD, Kranzler HR, Pietrzak RH, Gelernter J. Psychol Med. 2024 Jun; 2024 Feb 6. PMID: 38317430.", + "Candidate Genes from an FDA-Approved Algorithm Fail to Predict Opioid Use Disorder Risk in Over 450,000 Veterans. Davis CN, Jinwala Z, Hatoum AS, Toikumo S, Agrawal A, Rentsch CT, Edenberg HJ, Baurley JW, Hartwell EE, Crist RC, Gray JC, Justice AC, Gelernter J, Kember RL, Kranzler HR. medRxiv. 2024 May 16; 2024 May 16. PMID: 38798430.", + "Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. Nievergelt CM, Maihofer AX, Atkinson EG, Chen CY, Choi KW, Coleman JRI, Daskalakis NP, Duncan LE, Polimanti R, Aaronson C, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegoviç E, Babić D, Bacanu SA, Baker DG, Batzler A, Beckham JC, Belangero S, Benjet C, Bergner C, Bierer LM, Biernacka JM, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Brandolino A, Breen G, Bressan RA, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Bækvad-Hansen M, Børglum AD, Børte S, Cahn L, Calabrese JR, Caldas-de-Almeida JM, Chatzinakos C, Cheema S, Clouston SAP, Colodro-Conde L, Coombes BJ, Cruz-Fuentes CS, Dale AM, Dalvie S, Davis LK, Deckert J, Delahanty DL, Dennis MF, Desarnaud F, DiPietro CP, Disner SG, Docherty AR, Domschke K, Dyb G, Kulenović AD, Edenberg HJ, Evans A, Fabbri C, Fani N, Farrer LA, Feder A, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gelaye B, Gelernter J, Geuze E, Gillespie CF, Goleva SB, Gordon SD, Goçi A, Grasser LR, Guindalini C, Haas M, Hagenaars S, Hauser MA, Heath AC, Hemmings SMJ, Hesselbrock V, Hickie IB, Hogan K, Hougaard DM, Huang H, Huckins LM, Hveem K, Jakovljević M, Javanbakht A, Jenkins GD, Johnson J, Jones I, Jovanovic T, Karstoft KI, Kaufman ML, Kennedy JL, Kessler RC, Khan A, Kimbrel NA, King AP, Koen N, Kotov R, Kranzler HR, Krebs K, Kremen WS, Kuan PF, Lawford BR, Lebois LAM, Lehto K, Levey DF, Lewis C, Liberzon I, Linnstaedt SD, Logue MW, Lori A, Lu Y, Luft BJ, Lupton MK, Luykx JJ, Makotkine I, Maples-Keller JL, Marchese S, Marmar C, Martin NG, Martínez-Levy GA, McAloney K, McFarlane A, McLaughlin KA, McLean SA, Medland SE, Mehta D, Meyers J, Michopoulos V, Mikita EA, Milani L, Milberg W, Miller MW, Morey RA, Morris CP, Mors O, Mortensen PB, Mufford MS, Nelson EC, Nordentoft M, Norman SB, Nugent NR, O'Donnell M, Orcutt HK, Pan PM, Panizzon MS, Pathak GA, Peters ES, Peterson AL, Peverill M, Pietrzak RH, Polusny MA, Porjesz B, Powers A, Qin XJ, Ratanatharathorn A, Risbrough VB, Roberts AL, Rothbaum AO, Rothbaum BO, Roy-Byrne P, Ruggiero KJ, Rung A, Runz H, Rutten BPF, de Viteri SS, Salum GA, Sampson L, Sanchez SE, Santoro M, Seah C, Seedat S, Seng JS, Shabalin A, Sheerin CM, Silove D, Smith AK, Smoller JW, Sponheim SR, Stein DJ, Stensland S, Stevens JS, Sumner JA, Teicher MH, Thompson WK, Tiwari AK, Trapido E, Uddin M, Ursano RJ, Valdimarsdóttir U, Van Hooff M, Vermetten E, Vinkers CH, Voisey J, Wang Y, Wang Z, Waszczuk M, Weber H, Wendt FR, Werge T, Williams MA, Williamson DE, Winsvold BS, Winternitz S, Wolf C, Wolf EJ, Xia Y, Xiong Y, Yehuda R, Young KA, Young RM, Zai CC, Zai GC, Zervas M, Zhao H, Zoellner LA, Zwart JA, deRoon-Cassini T, van Rooij SJH, van den Heuvel LL, Stein MB, Ressler KJ, Koenen KC. Nat Genet. 2024 May; 2024 Apr 18. PMID: 38637617.", + "A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals. Jennings MV, Martínez-Magaña JJ, Courchesne-Krak NS, Cupertino RB, Vilar-Ribó L, Bianchi SB, Hatoum AS, Atkinson EG, Giusti-Rodriguez P, Montalvo-Ortiz JL, Gelernter J, Artigas MS, Elson SL, Edenberg HJ, Fontanillas P, Palmer AA, Sanchez-Roige S. EBioMedicine. 2024 May; 2024 Apr 4. PMID: 38580523.", + "Polygenic risk for suicide attempt is associated with lifetime suicide attempt in US soldiers independent of parental risk. Stein MB, Jain S, Papini S, Campbell-Sills L, Choi KW, Martis B, Sun X, He F, Ware EB, Naifeh JA, Aliaga PA, Ge T, Smoller JW, Gelernter J, Kessler RC, Ursano RJ. J Affect Disord. 2024 Apr 15; 2024 Feb 1. PMID: 38309480.", + "A Multivariate Genome-Wide Association Study Reveals Neural Correlates and Common Biological Mechanisms of Psychopathology Spectra. Davis C, Khan Y, Toikumo S, Jinwala Z, Boomsma D, Levey D, Gelernter J, Kember R, Kranzler H. Res Sq. 2024 Apr 8; 2024 Apr 8. PMID: 38659902.", + "Multi-ancestry Whole-exome Sequencing Study of Alcohol Use Disorder in Two Cohorts. Wang L, Kranzler HR, Gelernter J, Zhou H. medRxiv. 2024 Apr 8; 2024 Apr 8. PMID: 38645055.", + "A multi-ancestry genetic study of pain intensity in 598,339 veterans. Toikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell EE, Pavicic M, Sullivan KA, Xu K, Jacobson DA, Gelernter J, Rentsch CT, Stahl E, Cheatle M, Zhou H, Waxman SG, Justice AC, Kember RL, Kranzler HR. Nat Med. 2024 Apr; 2024 Mar 1. PMID: 38429522.", + "Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders. Koller D, Mitjans M, Kouakou M, Friligkou E, Cabrera-Mendoza B, Deak JD, Llonga N, Pathak GA, Stiltner B, Løkhammer S, Levey DF, Zhou H, Hatoum AS, Kember RL, Kranzler HR, Stein MB, Corominas R, Demontis D, Artigas MS, Ramos-Quiroga JA, Gelernter J, Ribasés M, Cormand B, Polimanti R. Psychiatry Res. 2024 Mar; 2024 Feb 3. PMID: 38335780.", + "Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Tamman AJF, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Polimanti R, Pietrzak RH. Neuropsychopharmacology. 2024 Mar. PMID: 38182778.", + "Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Tamman AJF, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Polimanti R, Pietrzak RH. Neuropsychopharmacology. 2024 Mar; 2023 Oct 17. PMID: 37848731.", + "Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression. Tian R, Ge T, Kweon H, Rocha DB, Lam M, Liu JZ, Singh K, Levey DF, Gelernter J, Stein MB, Tsai EA, Huang H, Chabris CF, Lencz T, Runz H, Chen CY. Nat Commun. 2024 Feb 26; 2024 Feb 26. PMID: 38409228.", + "Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference. Meng X, Navoly G, Giannakopoulou O, Levey DF, Koller D, Pathak GA, Koen N, Lin K, Adams MJ, Rentería ME, Feng Y, Gaziano JM, Stein DJ, Zar HJ, Campbell ML, van Heel DA, Trivedi B, Finer S, McQuillin A, Bass N, Chundru VK, Martin HC, Huang QQ, Valkovskaya M, Chu CY, Kanjira S, Kuo PH, Chen HC, Tsai SJ, Liu YL, Kendler KS, Peterson RE, Cai N, Fang Y, Sen S, Scott LJ, Burmeister M, Loos RJF, Preuss MH, Actkins KV, Davis LK, Uddin M, Wani AH, Wildman DE, Aiello AE, Ursano RJ, Kessler RC, Kanai M, Okada Y, Sakaue S, Rabinowitz JA, Maher BS, Uhl G, Eaton W, Cruz-Fuentes CS, Martinez-Levy GA, Campos AI, Millwood IY, Chen Z, Li L, Wassertheil-Smoller S, Jiang Y, Tian C, Martin NG, Mitchell BL, Byrne EM, Awasthi S, Coleman JRI, Ripke S, Sofer T, Walters RG, McIntosh AM, Polimanti R, Dunn EC, Stein MB, Gelernter J, Lewis CM, Kuchenbaecker K. Nat Genet. 2024 Feb; 2024 Jan 4. PMID: 38177345.", + "Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and medical traits. Hartwell EE, Jinwala Z, Milone J, Ramirez S, Gelernter J, Kranzler HR, Kember RL. medRxiv. 2024 Jan 23; 2024 Jan 23. PMID: 38343859.", + "Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking. Johnson EC, Austin-Zimmerman I, Thorpe HH, Levey DF, Baranger DA, Colbert SM, Demontis D, Khokhar JY, Davis LK, Edenberg HJ, Forti MD, Sanchez-Roige S, Gelernter J, Agrawal A. medRxiv. 2024 Jan 18; 2024 Jan 18. PMID: 38293235.", + "A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. Gupta P, Galimberti M, Liu Y, Beck S, Wingo A, Wingo T, Adhikari K, Stein MB, Gelernter J, Levey DF. medRxiv. 2024 Jan 17; 2024 Jan 17. PMID: 38293137.", + "Identification of Novel Loci and Cross-Disorder Pleiotropy Through Multi-Ancestry Genome-Wide Analysis of Alcohol Use Disorder in Over One Million Individuals. Icick R, Shadrin A, Holen B, Karadag N, Parker N, O'Connell K, Frei O, Bahrami S, Høegh M, Lagerberg T, Cheng W, Seibert T, Djurovic S, Dale A, Zhou H, Edenberg H, Gelernter J, Smeland O, Hindley G, Andreassen O. Res Sq. 2023 Dec 22; 2023 Dec 22. PMID: 38196616.", + "Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals. Zhou H, Kember RL, Deak JD, Xu H, Toikumo S, Yuan K, Lind PA, Farajzadeh L, Wang L, Hatoum AS, Johnson J, Lee H, Mallard TT, Xu J, Johnston KJA, Johnson EC, Nielsen TT, Galimberti M, Dao C, Levey DF, Overstreet C, Byrne EM, Gillespie NA, Gordon S, Hickie IB, Whitfield JB, Xu K, Zhao H, Huckins LM, Davis LK, Sanchez-Roige S, Madden PAF, Heath AC, Medland SE, Martin NG, Ge T, Smoller JW, Hougaard DM, Børglum AD, Demontis D, Krystal JH, Gaziano JM, Edenberg HJ, Agrawal A, Justice AC, Stein MB, Kranzler HR, Gelernter J. Nat Med. 2023 Dec; 2023 Dec 7. PMID: 38062264.", + "Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications. Levey DF, Galimberti M, Deak JD, Wendt FR, Bhattacharya A, Koller D, Harrington KM, Quaden R, Johnson EC, Gupta P, Biradar M, Lam M, Cooke M, Rajagopal VM, Empke SLL, Zhou H, Nunez YZ, Kranzler HR, Edenberg HJ, Agrawal A, Smoller JW, Lencz T, Hougaard DM, Børglum AD, Demontis D, Gaziano JM, Gandal MJ, Polimanti R, Stein MB, Gelernter J. Nat Genet. 2023 Dec; 2023 Nov 20. PMID: 37985822.", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Glahn Lab", + "lab_url": "https://medicine.yale.edu/lab/glahn/", + "research_bio": "INFORMATION FOR The primary aims of our laboratory are: Thus, our work involves the characterization of the multi-scale influence of genetic variation on basic physiology, brain networks, neurocognition, and on the complex clinical features and common comorbidities observed in affective and psychotic disorders. Interpretation of such findings is predicated on a clear understanding of the genetic control of normal neuroanatomic, neurophysiologic and cognitive variation, particularly since genes influencing normal variation are often also associated with pathology. Therefore, a major component of our research focuses on determining the genetic aspects of individual differences. Furthermore, as development and aging appear to impact the prevalence and presentation of affective and psychotic disorders, our group endeavors to identify and characterize the genetic influences of developmental/degenerative trajectories. Our research on schizophrenia, bipolar disorder and recurrent major depression, combined with methods development, is designed to enhance our ability to identify, treat, and, potentially, prevent these debilitating disorders. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Glaucoma Research Group", + "lab_url": "https://medicine.yale.edu/lab/glaucoma/", + "research_bio": "INFORMATION FOR The Yale Glaucoma Research Group is comprised of internationally respected physicians and research scientists who seek to decrease preventable blindness from glaucoma through medical and surgical management, research, and community awareness. Dr. Christopher Teng, Dr. Ji Liu, Dr. Soshian Sarrafpour, and Dr. James Martone offer a complete range of services for patients with glaucoma and related anterior segment diseases. With continued study to improve their understanding of the diagnosis and management of glaucoma, they offer the latest advances in treating all forms of glaucoma. Physicians are fellowship trained and play a vital role in bringing into practice new modalities in diagnosing and treating these diseases. The Yale Glaucoma team utilizes the most technologically advanced instrumentation including perimetry, Optical Coherence Tomography (Spectral Domain and OCTA), wide field fundus photography, ultrasound biomicroscopy and Argon, SLT, Nd-YAG, and micropulse laser systems. The state-of-the-art operating rooms have the most advanced equipment including Femtosecond laser, intraoperative aberrometry and the newest operating microscopes. Special services offered include:", + "publications_page": "https://medicine.yale.edu/lab/glaucoma/publications/", + "publications": [ + "Yale School of Medicine /", + "Ophthalmology /", + "Team Members & People", + "Recent Activity", + "Research & Projects", + "Publications", + "Education & Fellowship", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Team Members & People", + "Research & Projects", + "Publications", + "Education & Fellowship", + "Recent Activity", + "", + "", + "", + "", + "", + "", + "Traumatic Glaucoma Managed With Ab Interno Trabeculotomy (Trabectome®): A Case Report. Perez AM, Gutkind NE, Liu J, Grippo TM. Cureus. 2025 May; 2025 May 7. PMID: 40486364.", + "Association between Device Manufacturer Payments to Surgeons and Minimally Invasive Glaucoma Surgery Utilization in the United States. Demkowicz PC, Teng CC, Liu J, Sarrafpour S. Ophthalmol Glaucoma. 2025 Mar-Apr; 2024 Nov 12. PMID: 39537114.", + "Ocular Gene Therapy: An Overview of Viral Vectors, Immune Responses, and Future Directions. Banou L, Sarrafpour S, Teng CC, Liu J. Yale J Biol Med. 2024 Dec; 2024 Dec 19. PMID: 39703610.", + "Domestic Violence-Related Ocular Injuries Among Adult Patients: Data from the Nationwide Emergency Department Sample, 2008-2017. Andoh JE, Mehta SK, Chen EM, Mir TA, Nwanyanwu K, Teng CC. Ophthalmic Epidemiol. 2024 Apr; 2023 Jun 22. PMID: 37345877.", + "External Disruption of Ocular Development in Utero. Kim HS, Sarrafpour S, Teng CC, Liu J. Yale J Biol Med. 2024 Mar; 2024 Mar 29. PMID: 38559457.", + "Development and Evaluation of Aeyeconsult: A Novel Ophthalmology Chatbot Leveraging Verified Textbook Knowledge and GPT-4. Singer MB, Fu JJ, Chow J, Teng CC. J Surg Educ. 2024 Mar; 2023 Dec 21. PMID: 38135548.", + "Epidemiologic trends of domestic violence-related ocular injuries among pediatric patients: data from the Nationwide Emergency Department Sample 2008-2017. Andoh JE, Miguez S, Andoh SE, Mehta S, Mir TA, Chen EM, Jain S, Teng CC, Nwanyanwu K. J AAPOS. 2023 Dec; 2023 Nov 4. PMID: 37931837.", + "Factors Associated With Visual Impairment Among Adults With a History of Criminal Justice Involvement. Andoh JE, Mir TA, Teng CC, Wang EA, Nwanyanwu K. J Correct Health Care. 2023 Oct; 2023 Oct 9. PMID: 37733299.", + "Top 5 Tips for Preparing Ophthalmology Residency and Fellowship Applicants. Marks V, Steren BJ, Linderman W, Teng CC, Chow JH, Kombo N. J Acad Ophthalmol (2017). 2023 Jan; 2023 Jan 13. PMID: 38737152.", + "Kahook Dual Blade versus Trabectome (KVT): Comparing Outcomes in Combination with Cataract Surgery. Fliney GD, Kim E, Sarwana M, Wong S, Tai TYT, Liu J, Sarrafpour S, Chadha N, Teng CC. Clin Ophthalmol. 2023; 2023 Jan 10. PMID: 36647517.", + "Gender Differences in Ophthalmic Procedural Volume: A Study of Male vs. Female Glaucoma Specialists. Andoh JE, Feng PW, Mir TA, Yoon J, Chadha N, Teng CC. Ophthalmol Glaucoma. 2022 Nov-Dec; 2022 Apr 9. PMID: 35405381.", + "Large Hyphema following Femtosecond Laser-assisted Cataract Surgery (FLACS) and Trabectome Resulting in Endocapsular Hematoma. Chang EL, Apostolopoulos N, Mir TA, Freedman IG, Teng CC. J Curr Glaucoma Pract. 2022 Sep-Dec. PMID: 36793266.", + "Emergency Department Presentations of Acute Primary Angle Closure in the United States from 2008 to 2017. Mehta SK, Mir T, Freedman IG, Sheth AH, Sarrafpour S, Liu J, Teng CC. Clin Ophthalmol. 2022; 2022 Jul 27. PMID: 35924186.", + "Suprachoroidal Hemorrhage after XEN Gel Implant Requiring Surgical Drainage. Wang K, Wang JC, Sarrafpour S. J Curr Glaucoma Pract. 2022 May-Aug. PMID: 36128082.", + "Anterior Subcapsular Cataract Formation With Long-term Topical Netarsudil Treatment for Glaucoma. Chang EL, Emmel DK, Teng CC, Sarrafpour S, Liu J. J Glaucoma. 2022 Jan 1. PMID: 34731868.", + "Cataract Surgery in Malignant Glaucoma from Complete Subluxation of Lens into Anterior Chamber. Sarrafpour S, Davies I, Ahmed O, Liu J, Teng CC. J Curr Glaucoma Pract. 2021 Sep-Dec. PMID: 35173401.", + "Ophthalmology Departments Remain Among the Least Diverse Clinical Departments at United States Medical Schools. Fairless EA, Nwanyanwu KH, Forster SH, Teng CC. Ophthalmology. 2021 Aug; 2021 Jan 10. PMID: 33440211.", + "Fractal Dimension Analysis of OCTA Images of Diabetic Retinopathy Using Circular Mass-Radius Method. Hashmi S, Lopez J, Chiu B, Sarrafpour S, Gupta A, Young J. Ophthalmic Surg Lasers Imaging Retina. 2021 Mar; 2021 Mar 1. PMID: 34038685.", + "Impact of iStent Micro-Bypass Shunt on Medicare Part B Glaucoma Surgical Expenditure. Lee JH, Ma AK, Warren JL, Teng CC. Ophthalmol Glaucoma. 2021 Mar-Apr; 2020 May 22. PMID: 33771334.", + "Ophthalmologists in the First Year of the Merit-based Incentive Payment System. Feng PW, Gronbeck C, Chen EM, Teng CC. Ophthalmology. 2021 Jan; 2020 Jun 6. PMID: 32522555.", + "Ophthalmic Medication Expenditures and Out-of-Pocket Spending: An Analysis of United States Prescriptions from 2007 through 2016. Chen EM, Kombo N, Teng CC, Mruthyunjaya P, Nwanyanwu K, Parikh R. Ophthalmology. 2020 Oct; 2020 Apr 28. PMID: 32359935.", + "GlaucoMap - Distribution of Glaucoma Surgical Procedures in the United States. Ma AK, Lee JH, Warren JL, Teng CC. Clin Ophthalmol. 2020; 2020 Aug 28. PMID: 32943836.", + "Herbal Medicines in Glaucoma Treatment. Ige M, Liu J. Yale J Biol Med. 2020 Jun; 2020 Jun 29. PMID: 32607093.", + "Microinvasive Glaucoma Surgical Training in United States Ophthalmology Residency Programs. Yim CK, Teng CC, Warren JL, Tsai JC, Chadha N. Clin Ophthalmol. 2020; 2020 Jun 26. PMID: 32636608.", + "Micropulse Transscleral Cyclophotocoagulation: A Look at Long-Term Effectiveness and Outcomes. Sarrafpour S, Saleh D, Ayoub S, Radcliffe NM. Ophthalmol Glaucoma. 2019 May-Jun; 2019 Feb 8. PMID: 32672586.", + "Cyclodialysis Cleft Associated with Kahook Dual Blade Goniotomy. Shue A, Levine RM, Gallousis GM, Teng CC. J Curr Glaucoma Pract. 2019 May-Aug. PMID: 31564797.", + "Choroidal Hemangioma in a Black Patient With Sturge-Weber Syndrome: Challenges in Diagnosis. Sarrafpour S, Tsui E, Mehta N, Modi YS, Finger PT. Ophthalmic Surg Lasers Imaging Retina. 2019 Mar 1. PMID: 30893453.", + "Seven- and eight-year trends in resident and fellow glaucoma surgical experience. Chadha N, Warren JL, Liu J, Tsai JC, Teng CC. Clin Ophthalmol. 2019; 2019 Feb 8. PMID: 30804662.", + "Streptococcus Dysgalactiae Subspecies Equisimilis Endogenous Endophthalmitis Associated with Aortic Valve Abscess. Gupta A, Tsui E, Sarrafpour S, Lee CM, Modi YS. Ocul Immunol Inflamm. 2019; 2018 Jul 3. PMID: 29969334.", + "Educational and Scholarly Opportunities for Medical Students and Residents in Professional Ophthalmology Organizations. Yang A, Zhang X, Liu J, Chow J, Adelman R, Forster S. JAMA Ophthalmol. 2018 Dec 1. PMID: 30326048.", + "Delayed cystoid macular oedema after uncomplicated laser peripheral iridotomy. Yang AY, Kempton J, Liu J. Clin Exp Ophthalmol. 2018 Sep; 2018 Mar 25. PMID: 29468783.", + "Corneal hysteresis and anterior segment optical coherence tomography anatomical parameters in primary angle closure suspects. Hussnain SA, Kovacs KD, Warren JL, Teng CC. Clin Exp Ophthalmol. 2018 Jul; 2018 Jan 11. PMID: 29251401.", + "Corneal Innervation and Sensation: The Eye and Beyond. Yang AY, Chow J, Liu J. Yale J Biol Med. 2018 Mar; 2018 Mar 28. PMID: 29599653.", + "Sequential cataract surgeries in a patient with a left ventricular assist device (LVAD). Yang A, Liu J. BMJ Case Rep. 2018 Mar 16; 2018 Mar 16. PMID: 29549136.", + "Improving Glaucoma Surgical Outcomes with Adjunct Tools. J Lu L, Hall L, Liu J. J Curr Glaucoma Pract. 2018 Jan-Apr; 2018 Mar 1. PMID: 29861578.", + "Posterior Scleritis with Choroidal Effusion Secondary to Herpes Zoster Ophthalmicus. Tsui E, Sarrafpour S, Modi YS. Ocul Immunol Inflamm. 2018; 2017 Oct 5. PMID: 28981391.", + "Phaco capsulotomy: a technique to prevent the Argentinean Flag Sign. Teng CC. Clin Ophthalmol. 2017; 2017 Nov 6. PMID: 29184382.", + "Management of Blood Pressure in Patients with Glaucoma. Levine RM, Yang A, Brahma V, Martone JF. Curr Cardiol Rep. 2017 Sep 19; 2017 Sep 19. PMID: 28929290.", + "Incremental Revisions across the Life Span of Ophthalmic Devices after Initial Food and Drug Administration Premarket Approval, 1979-2015. Gopal AD, Rathi VK, Teng CC, Del Priore L, Ross JS. Ophthalmology. 2017 Aug; 2017 May 10. PMID: 28501378.", + "Novel therapeutics for Stargardt disease. Lu LJ, Liu J, Adelman RA. Graefes Arch Clin Exp Ophthalmol. 2017 Jun; 2017 Mar 11. PMID: 28285324.", + "Irreversible Blindness Following Periocular Autologous Platelet-Rich Plasma Skin Rejuvenation Treatment. Kalyam K, Kavoussi SC, Ehrlich M, Teng CC, Chadha N, Khodadadeh S, Liu J. Ophthalmic Plast Reconstr Surg. 2017 May/Jun. PMID: 27015236.", + "Choroidal Vessel Diameters in Pseudoexfoliation and Pseudoexfoliation Glaucoma Analyzed Using Spectral-Domain Optical Coherence Tomography. Sarrafpour S, Adhi M, Zhang JY, Duker JS, Krishnan C. J Glaucoma. 2017 Apr. PMID: 28169922.", + "Novel Pharmacologic Candidates for Treatment of Primary Open-Angle Glaucoma. Lu LJ, Tsai JC, Liu J. Yale J Biol Med. 2017 Mar; 2017 Mar 29. PMID: 28356898.", + "Epigenetics and Signaling Pathways in Glaucoma. Gauthier AC, Liu J. Biomed Res Int. 2017; 2017 Jan 22. PMID: 28210622.", + "Epigenetics and Common Ophthalmic Diseases. Li W, Liu J, Galvin JA. Yale J Biol Med. 2016 Dec; 2016 Dec 23. PMID: 28018148.", + "Effect of supine body position on central corneal thickness. Maslin JS, Teng CC, Chadha N, Liu J. Clin Exp Ophthalmol. 2016 Nov; 2016 Apr 5. PMID: 26991869.", + "Free-Floating, Pigmented Cysts in the Anterior Chamber Causing Ocular Hypertension. Maslin JS, Teng CC, Materin M. Ocul Oncol Pathol. 2016 Oct; 2016 Jun 3. PMID: 27843903.", + "Human Microbiota and Ophthalmic Disease. Lu LJ, Liu J. Yale J Biol Med. 2016 Sep; 2016 Sep 30. PMID: 27698616.", + "Trends in ophthalmology resident surgical experience from 2009 to 2015. Chadha N, Liu J, Maslin JS, Teng CC. Clin Ophthalmol. 2016; 2016 Jun 28. PMID: 27418803.", + "Risk factors for visual impairment associated with corneal diseases in southern China. Xu SC, Chow J, Liu J, Li L, Maslin JS, Chadha N, Chen B, Teng CC. Clin Ophthalmol. 2016; 2016 May 2. PMID: 27194904.", + "Efficacy of the Amsler Grid Test in Evaluating Glaucomatous Central Visual Field Defects. Su D, Greenberg A, Simonson JL, Teng CC, Liebmann JM, Ritch R, Park SC. Ophthalmology. 2016 Apr; 2016 Jan 9. PMID: 26783097.", + "Neurodegeneration and Neuroprotection in Glaucoma. Gauthier AC, Liu J. Yale J Biol Med. 2016 Mar; 2016 Mar 24. PMID: 27505018.", + "Applications of Scheimpflug Imaging in Glaucoma Management: Current and Potential Applications. Nguyen AT, Liu T, Liu J. J Ophthalmol. 2016; 2016 Dec 4. PMID: 28044101.", + "The Application of a Contact Lens Sensor in Detecting 24-Hour Intraocular Pressure-Related Patterns. Xu SC, Gauthier AC, Liu J. J Ophthalmol. 2016; 2016 Jul 25. PMID: 27525110.", + "Marijuana for Glaucoma: A Recipe for Disaster or Treatment? Sun X, Xu CS, Chadha N, Chen A, Liu J. Yale J Biol Med. 2015 Sep; 2015 Sep 3. PMID: 26339209.", + "Resident and Fellow Glaucoma Surgical Experience Following the Tube Versus Trabeculectomy Study. Chadha N, Liu J, Teng CC. Ophthalmology. 2015 Sep; 2015 Apr 22. PMID: 25911055.", + "Spontaneous hyphema and pupillary block in a patient with a left ventricular assist device. Kavoussi SC, Liu J. Digit J Ophthalmol. 2015; 2015 Jun 11. PMID: 27330463.", + "Evaluation of an injectable thermosensitive hydrogel as drug delivery implant for ocular glaucoma surgery. Xi L, Wang T, Zhao F, Zheng Q, Li X, Luo J, Liu J, Quan D, Ge J. PLoS One. 2014; 2014 Jun 20. PMID: 24950176.", + "Peripheral laser iridoplasty opens angle in plateau iris by thinning the cross-sectional tissues. Liu J, Lamba T, Belyea DA. Clin Ophthalmol. 2013; 2013 Sep 23. PMID: 24109168.", + "Repeat selective laser trabeculoplasty. Hong BK, Winer JC, Martone JF, Wand M, Altman B, Shields B. J Glaucoma. 2009 Mar. PMID: 19295367.", + "Evaluation of a modified protocol for selective laser trabeculoplasty. George MK, Emerson JW, Cheema SA, McGlynn R, Ford BA, Martone JF, Shields MB, Wand M. J Glaucoma. 2008 Apr-May. PMID: 18414105.", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Glazer Lab", + "lab_url": "https://medicine.yale.edu/lab/glazer/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/glazer/pubs/", + "publications": [ + "Yale School of Medicine /", + "Therapeutic Radiology /", + "Research DNA Repair Cancer Therapy Hypoxia Gene Editing", + "DNA Repair", + "Cancer Therapy", + "Hypoxia", + "Gene Editing", + "People", + "Publications", + "Contact Us", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Cell-penetrating antibody enhances nuclear delivery of triplex-forming oligonucleotides targeting HER2-positive cancers. Minnah A, García Tubéns NM, Krysztofiak A, Liu Y, Glazer PM, Rogers FA. Mol Ther Nucleic Acids. 2025 Dec 9; 2025 Sep 20. PMID: 41127334.", + "Harnessing ExDNA for precision exatecan delivery in cancer: a novel antibody-drug conjugate approach. Ianniello Z, Lu H, Quijano E, Colón-Ríos DA, Rackear M, Bommireddy V, Ludwig DL, Shen Z, Glazer PM. Mol Cancer. 2025 Oct 13; 2025 Oct 13. PMID: 41077566.", + "Hypoxia Induces Immunosuppression by Silencing STING in Cancer. Lu Y, Yurkevicz AM, Liu Y, Glazer PM. Cancer Res. 2025 Sep 12; 2025 Sep 12. PMID: 40939188.", + "Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery. Lynn AY, Shin K, Eaton DA, Rose M, Zhang X, Ene M, Grundler J, Deschenes E, Rivero R, Bracaglia LG, Glazer PM, Stitelman DH, Saltzman WM. Biomaterials. 2025 Sep; 2025 Mar 6. PMID: 40064138.", + "Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer. Quijano E, Martinez-Saucedo D, Ianniello Z, Pinto-Medici N, Rackear M, Chen H, Lola-Pereira L, Liu Y, Hegan D, Shan X, Tseng R, Yugawa D, Chowdhury S, Khang M, Singh JP, Abdullah R, Azhir P, Kashima S, Woods WS, Gosstola N, Turner BC, Squinto S, Ludwig DL, Bindra RS, Robert ME, Braun DA, Perez Pinera P, Saltzman WM, Escobar-Hoyos LF, Glazer PM. Sci Transl Med. 2025 Jul 16; 2025 Jul 16. PMID: 40668891.", + "Systemic in utero gene editing as a treatment for cystic fibrosis. Ricciardi AS, Barone C, Putman R, Quijano E, Gupta A, Nguyen R, Mandl H, Piotrowski-Daspit AS, Lopez-Giraldez F, Luks V, Freedman-Weiss MR, Farrelly J, Ahle S, Lynn AY, Glazer PM, Saltzman WM, Stitelman DH, Egan ME. Proc Natl Acad Sci U S A. 2025 Jun 17; 2025 Jun 10. PMID: 40493185.", + "Tumor-Specific Antigen Delivery for T-cell Therapy via a pH-Sensitive Peptide Conjugate. Yurkevicz AM, Liu Y, Katz SG, Glazer PM. Mol Cancer Ther. 2025 Jan 2. PMID: 39382073.", + "Biodistribution of Polymeric Nanoparticles following in utero Delivery to a Nonhuman Primate. Eaton DA, Lynn AY, Surprenant JM, Deschenes EI, Guerra ME, Rivero R, Yung NK, O'Connor M, Glazer PM, Bahtiyar MO, Saltzman WM, Stitelman DH. Biomed Hub. 2025 Jan-Dec; 2024 Dec 12. PMID: 39845408.", + "Next generation triplex-forming PNAs for site-specific genome editing of the F508del CFTR mutation. Gupta A, Barone C, Quijano E, Piotrowski-Daspit AS, Perera JD, Riccardi A, Jamali H, Turchick A, Zao W, Saltzman WM, Glazer PM, Egan ME. J Cyst Fibros. 2025 Jan; 2024 Aug 5. PMID: 39107154.", + "Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition. Rackear M, Quijano E, Ianniello Z, Colón-Ríos DA, Krysztofiak A, Abdullah R, Liu Y, Rogers FA, Ludwig DL, Dwivedi R, Bleichert F, Glazer PM. Oncotarget. 2024 Oct 1; 2024 Oct 1. PMID: 39352803.", + "Peptide Nucleic Acid-Mediated Regulation of CRISPR-Cas9 Specificity. Carufe KEW, Economos NG, Glazer PM. Nucleic Acid Ther. 2024 Oct; 2024 Jul 22. PMID: 39037032.", + "Systemic in utero gene editing as a treatment for cystic fibrosis. Ricciardi AS, Barone C, Putman R, Quijano E, Gupta A, Nguyen R, Mandl H, Piotrowski-Daspit AS, Lopez-Giraldez F, Luks V, Freedman-Weiss MR, Farrelly J, Ahle S, Glazer PM, Saltzman WM, Stitelman DH, Egan ME. bioRxiv. 2024 Sep 8; 2024 Sep 8. PMID: 39282330.", + "The technical and ethical framework of fetal therapy: past and current advances. Lynn AY, Glazer PM, Saltzman WM, Stitelman DH. Curr Stem Cell Rep. 2024 Jun; 2024 Apr 19. PMID: 41048874.", + "Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy. Verma N, Renauer PA, Dong C, Xin S, Lin Q, Zhang F, Glazer PM, Chen S. bioRxiv. 2024 Jan 15; 2024 Jan 15. PMID: 38293095.", + "Harnessing the effects of hypoxia-like inhibition on homology-directed DNA repair. Altwerger G, Ghazarian M, Glazer PM. Semin Cancer Biol. 2024 Jan; 2023 Nov 28. PMID: 38029867.", + "Head-to-head comparison of in vitro and in vivo efficacy of pHLIP-conjugated anti-seed gamma peptide nucleic acids. Dhuri K, Duran T, Chaudhuri B, Slack FJ, Vikram A, Glazer PM, Bahal R. Cell Rep Phys Sci. 2023 Oct 18; 2023 Sep 15. PMID: 38144419.", + "DNA recognition and induced genome modification by a hydroxymethyl-γ tail-clamp peptide nucleic acid. Oyaghire SN, Quijano E, Perera JDR, Mandl HK, Saltzman WM, Bahal R, Glazer PM. Cell Rep Phys Sci. 2023 Oct 18. PMID: 37920723.", + "Acetylation of MLH1 by CBP increases cellular DNA mismatch repair activity. Zhang M, Zhao J, Glazer PM, Bai W, Bepler G, Zhang XM. J Biochem. 2023 Jul 31. PMID: 37094360.", + "Nanoparticle-mediated genome editing in single-cell embryos via peptide nucleic acids. Putman R, Ricciardi AS, Carufe KEW, Quijano E, Bahal R, Glazer PM, Saltzman WM. Bioeng Transl Med. 2023 May; 2022 Dec 2. PMID: 37206203.", + "Response to: Elevated L1 expression in ataxia telangiectasia likely explained by an RNA-seq batch effect. Takahashi T, Stoiljkovic M, Song E, Gao XB, Yasumoto Y, Kudo E, Carvalho F, Kong Y, Park A, Shanabrough M, Szigeti-Buck K, Liu ZW, Kristant A, Zhang Y, Sulkowski P, Glazer PM, Kaczmarek LK, Horvath TL, Iwasaki A. Neuron. 2023 Mar 1. PMID: 36863323.", + "Metastatic and multiply relapsed SDH-deficient GIST and paraganglioma displays clinical response to combined poly ADP-ribose polymerase inhibition and temozolomide. Singh C, Bindra RS, Glazer PM, Vasquez JC, Pashankar F. Pediatr Blood Cancer. 2023 Mar; 2022 Sep 24. PMID: 36151992.", + "Randomized Trial of Olaparib With or Without Cediranib for Metastatic Castration-Resistant Prostate Cancer: The Results From National Cancer Institute 9984. Kim JW, McKay RR, Radke MR, Zhao S, Taplin ME, Davis NB, Monk P, Appleman LJ, Lara PN Jr, Vaishampayan UN, Zhang J, Paul AK, Bubley G, Van Allen EM, Unlu S, Huang Y, Loda M, Shapiro GI, Glazer PM, LoRusso PM, Ivy SP, Shyr Y, Swisher EM, Petrylak DP. J Clin Oncol. 2023 Feb 1; 2022 Oct 18. PMID: 36256912.", + "LINE-1 activation in the cerebellum drives ataxia. Takahashi T, Stoiljkovic M, Song E, Gao XB, Yasumoto Y, Kudo E, Carvalho F, Kong Y, Park A, Shanabrough M, Szigeti-Buck K, Liu ZW, Kristant A, Zhang Y, Sulkowski P, Glazer PM, Kaczmarek LK, Horvath TL, Iwasaki A. Neuron. 2022 Oct 19; 2022 Sep 6. PMID: 36070749.", + "In vivo correction of cystic fibrosis mediated by PNA nanoparticles. Piotrowski-Daspit AS, Barone C, Lin CY, Deng Y, Wu D, Binns TC, Xu E, Ricciardi AS, Putman R, Garrison A, Nguyen R, Gupta A, Fan R, Glazer PM, Saltzman WM, Egan ME. Sci Adv. 2022 Oct 7; 2022 Oct 5. PMID: 36197984.", + "An ELISA-based platform for rapid identification of structure-dependent nucleic acid-protein interactions detects novel DNA triplex interactors. Economos NG, Thapar U, Balasubramanian N, Karras GI, Glazer PM. J Biol Chem. 2022 Oct; 2022 Aug 18. PMID: 35988651.", + "Antispacer peptide nucleic acids for sequence-specific CRISPR-Cas9 modulation. Economos NG, Quijano E, Carufe KEW, Perera JDR, Glazer PM. Nucleic Acids Res. 2022 Jun 10. PMID: 35235944.", + "Correction to 'Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity'. Gayle S, Aiello R, Leelatian N, Beckta JM, Bechtold J, Bourassa P, Csengery J, Maguire RJ, Marshall D, Sundaram RK, Van Doorn J, Jones K, Moore H, Lopresti-Morrow L, Paradis T, Tylaska L, Zhang Q, Visca H, Reshetnyak YK, Andreev OA, Engelman DM, Glazer PM, Bindra RS, Paralkar VM. NAR Cancer. 2021 Dec; 2021 Dec 7. PMID: 34888524.", + "Vulnerability of IDH1-Mutant Cancers to Histone Deacetylase Inhibition via Orthogonal Suppression of DNA Repair. Dow J, Krysztofiak A, Liu Y, Colon-Rios DA, Rogers FA, Glazer PM. Mol Cancer Res. 2021 Dec; 2021 Sep 17. PMID: 34535560.", + "Peptide nucleic acids and their role in gene regulation and editing. Perera JDR, Carufe KEW, Glazer PM. Biopolymers. 2021 Dec; 2021 Jun 15. PMID: 34129732.", + "Regulation of the Cell-Intrinsic DNA Damage Response by the Innate Immune Machinery. Hayman TJ, Glazer PM. Int J Mol Sci. 2021 Nov 25; 2021 Nov 25. PMID: 34884568.", + "BBIT20 inhibits homologous DNA repair with disruption of the BRCA1-BARD1 interaction in breast and ovarian cancer. Raimundo L, Paterna A, Calheiros J, Ribeiro J, Cardoso DSP, Piga I, Neto SJ, Hegan D, Glazer PM, Indraccolo S, Mulhovo S, Costa JL, Ferreira MU, Saraiva L. Br J Pharmacol. 2021 Sep; 2021 Jun 11. PMID: 33899955.", + "Clinical Activity and Safety of Cediranib and Olaparib Combination in Patients with Metastatic Pancreatic Ductal Adenocarcinoma without BRCA Mutation. Kim JW, Cardin DB, Vaishampayan UN, Kato S, Grossman SR, Glazer PM, Shyr Y, Ivy SP, LoRusso PM. Oncologist. 2021 Jul; 2021 May 5. PMID: 33742489.", + "Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity. Gayle S, Aiello R, Leelatian N, Beckta JM, Bechtold J, Bourassa P, Csengery J, Maguire RJ, Marshall D, Sundaram RK, Van Doorn J, Jones K, Moore H, Lopresti-Morrow L, Paradis T, Tylaska L, Zhang Q, Visca H, Reshetnyak YK, Andreev OA, Engelman DM, Glazer PM, Bindra RS, Paralkar VM. NAR Cancer. 2021 Jun; 2021 Jun 4. PMID: 34316708.", + "The NIH Somatic Cell Genome Editing program. Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB Jr, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J. Nature. 2021 Apr; 2021 Apr 7. PMID: 33828315.", + "Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance. Dong YL, Vadla GP, Lu JJ, Ahmad V, Klein TJ, Liu LF, Glazer PM, Xu T, Chabu CY. Commun Biol. 2021 Mar 19; 2021 Mar 19. PMID: 33742110.", + "Nanoparticles for delivery of agents to fetal lungs. Ullrich SJ, Freedman-Weiss M, Ahle S, Mandl HK, Piotrowski-Daspit AS, Roberts K, Yung N, Maassel N, Bauer-Pisani T, Ricciardi AS, Egan ME, Glazer PM, Saltzman WM, Stitelman DH. Acta Biomater. 2021 Mar 15; 2021 Jan 21. PMID: 33484911.", + "Targeting the Hypoxic and Acidic Tumor Microenvironment with pH-Sensitive Peptides. Dharmaratne NU, Kaplan AR, Glazer PM. Cells. 2021 Mar 4; 2021 Mar 4. PMID: 33806273.", + "Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK Pathway. Lu Y, Liu Y, Oeck S, Zhang GJ, Schramm A, Glazer PM. Cancer Res. 2020 Nov 1; 2020 Sep 1. PMID: 32873635.", + "Oncometabolites suppress DNA repair by disrupting local chromatin signalling. Sulkowski PL, Oeck S, Dow J, Economos NG, Mirfakhraie L, Liu Y, Noronha K, Bao X, Li J, Shuch BM, King MC, Bindra RS, Glazer PM. Nature. 2020 Jun; 2020 Jun 3. PMID: 32494005.", + "Ku80-Targeted pH-Sensitive Peptide-PNA Conjugates Are Tumor Selective and Sensitize Cancer Cells to Ionizing Radiation. Kaplan AR, Pham H, Liu Y, Oyaghire S, Bahal R, Engelman DM, Glazer PM. Mol Cancer Res. 2020 Jun; 2020 Feb 25. PMID: 32098827.", + "Impact of hypoxia on DNA repair and genome integrity. Kaplan AR, Glazer PM. Mutagenesis. 2020 Feb 13. PMID: 31282537.", + "Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair. Economos NG, Oyaghire S, Quijano E, Ricciardi AS, Saltzman WM, Glazer PM. Molecules. 2020 Feb 8; 2020 Feb 8. PMID: 32046275.", + "Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules Using a pH-Low Insertion Peptide. Svoronos AA, Bahal R, Pereira MC, Barrera FN, Deacon JC, Bosenberg M, DiMaio D, Glazer PM, Engelman DM. Mol Pharm. 2020 Feb 3; 2020 Jan 13. PMID: 31855437.", + "Pharmacological methods to transcriptionally modulate double-strand break DNA repair. Kaplan AR, Glazer PM. Int Rev Cell Mol Biol. 2020; 2019 Dec 18. PMID: 32475473.", + "Poly(Lactic-co-Glycolic Acid) Nanoparticle Delivery of Peptide Nucleic Acids In Vivo. Oyaghire SN, Quijano E, Piotrowski-Daspit AS, Saltzman WM, Glazer PM. Methods Mol Biol. 2020. PMID: 32088877.", + "Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response. Sahraei M, Chaube B, Liu Y, Sun J, Kaplan A, Price NL, Ding W, Oyaghire S, García-Milian R, Mehta S, Reshetnyak YK, Bahal R, Fiorina P, Glazer PM, Rimm DL, Fernández-Hernando C, Suárez Y. J Clin Invest. 2019 Dec 2. PMID: 31710308.", + "Mitochondrial DNA Stress Signalling Protects the Nuclear Genome. Wu Z, Oeck S, West AP, Mangalhara KC, Sainz AG, Newman LE, Zhang XO, Wu L, Yan Q, Bosenberg M, Liu Y, Sulkowski PL, Tripple V, Kaech SM, Glazer PM, Shadel GS. Nat Metab. 2019 Dec; 2019 Dec 9. PMID: 32395698.", + "Optimizing biodegradable nanoparticle size for tissue-specific delivery. Mandl HK, Quijano E, Suh HW, Sparago E, Oeck S, Grun M, Glazer PM, Saltzman WM. J Control Release. 2019 Nov 28; 2019 Oct 22. PMID: 31654688.", + "Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51. Kaplan AR, Gueble SE, Liu Y, Oeck S, Kim H, Yun Z, Glazer PM. Sci Transl Med. 2019 May 15. PMID: 31092693.", + "High-throughput Evaluation of Protein Migration and Localization after Laser Micro-Irradiation. Oeck S, Malewicz NM, Krysztofiak A, Turchick A, Jendrossek V, Glazer PM. Sci Rep. 2019 Feb 28; 2019 Feb 28. PMID: 30816253.", + "Synthetic lethality of a cell-penetrating anti-RAD51 antibody in PTEN-deficient melanoma and glioma cells. Turchick A, Liu Y, Zhao W, Cohen I, Glazer PM. Oncotarget. 2019 Feb 12; 2019 Feb 12. PMID: 30863489.", + "Electron-Mediated Aminyl and Iminyl Radicals from C5 Azido-Modified Pyrimidine Nucleosides Augment Radiation Damage to Cancer Cells. Wen Z, Peng J, Tuttle PR, Ren Y, Garcia C, Debnath D, Rishi S, Hanson C, Ward S, Kumar A, Liu Y, Zhao W, Glazer PM, Liu Y, Sevilla MD, Adhikary A, Wnuk SF. Org Lett. 2018 Dec 7; 2018 Nov 20. PMID: 30457873.", + "Pathologic Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma. Xu Y, Taylor P, Andrade J, Ueberheide B, Shuch B, Glazer PM, Bindra RS, Moran MF, Linehan WM, Neel BG. Cancer Res. 2018 Dec 1; 2018 Oct 8. PMID: 30297534.", + "Hypoxia Promotes Resistance to EGFR Inhibition in NSCLC Cells via the Histone Demethylases, LSD1 and PLU-1. Lu Y, Liu Y, Oeck S, Glazer PM. Mol Cancer Res. 2018 Oct; 2018 Jun 22. PMID: 29934325.", + "Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair. Sulkowski PL, Sundaram RK, Oeck S, Corso CD, Liu Y, Noorbakhsh S, Niger M, Boeke M, Ueno D, Kalathil AN, Bao X, Li J, Shuch B, Bindra RS, Glazer PM. Nat Genet. 2018 Aug; 2018 Jul 16. PMID: 30013182.", + "PTEN Regulates Nonhomologous End Joining By Epigenetic Induction of NHEJ1/XLF. Sulkowski PL, Scanlon SE, Oeck S, Glazer PM. Mol Cancer Res. 2018 Aug; 2018 May 8. PMID: 29739874.", + "In utero nanoparticle delivery for site-specific genome editing. Ricciardi AS, Bahal R, Farrelly JS, Quijano E, Bianchi AH, Luks VL, Putman R, López-Giráldez F, Coşkun S, Song E, Liu Y, Hsieh WC, Ly DH, Stitelman DH, Glazer PM, Saltzman WM. Nat Commun. 2018 Jun 26; 2018 Jun 26. PMID: 29946143.", + "Peptide Nucleic Acids as a Tool for Site-Specific Gene Editing. Ricciardi AS, Quijano E, Putman R, Saltzman WM, Glazer PM. Molecules. 2018 Mar 11; 2018 Mar 11. PMID: 29534473.", + "The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells. Kim H, Lin Q, Glazer PM, Yun Z. Breast Cancer Res. 2018 Mar 6; 2018 Mar 6. PMID: 29510720.", + "Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma. Scanlon SE, Hegan DC, Sulkowski PL, Glazer PM. Oncotarget. 2018 Jan 12; 2017 Dec 19. PMID: 29435132.", + "Therapeutic Peptide Nucleic Acids: Principles, Limitations, and Opportunities. Quijano E, Bahal R, Ricciardi A, Saltzman WM, Glazer PM. Yale J Biol Med. 2017 Dec; 2017 Dec 19. PMID: 29259523.", + "Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy. Gupta A, Quijano E, Liu Y, Bahal R, Scanlon SE, Song E, Hsieh WC, Braddock DE, Ly DH, Saltzman WM, Glazer PM. Mol Ther Nucleic Acids. 2017 Dec 15; 2017 Sep 12. PMID: 29246289.", + "A cell-penetrating antibody inhibits human RAD51 via direct binding. Turchick A, Hegan DC, Jensen RB, Glazer PM. Nucleic Acids Res. 2017 Nov 16. PMID: 29036688.", + "Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cells. Scanlon SE, Scanlon CD, Hegan DC, Sulkowski PL, Glazer PM. Carcinogenesis. 2017 Jun 1. PMID: 28472268.", + "DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy. Nemec AA, Abriola L, Merkel JS, de Stanchina E, DeVeaux M, Zelterman D, Glazer PM, Sweasy JB. Mol Cancer Res. 2017 Mar; 2017 Jan 10. PMID: 28074003.", + "2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity. Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, Surovtseva YV, Kachman M, Halene S, Günel M, Glazer PM, Bindra RS. Sci Transl Med. 2017 Feb 1. PMID: 28148839.", + "Nanotechnology for delivery of peptide nucleic acids (PNAs). Gupta A, Bahal R, Gupta M, Glazer PM, Saltzman WM. J Control Release. 2016 Oct 28; 2016 Jan 8. PMID: 26776051.", + "In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery. Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, López-Giráldez F, Ricciardi A, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Mark Saltzman W, Ly DH, Glazer PM. Nat Commun. 2016 Oct 26; 2016 Oct 26. PMID: 27782131.", + "miR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB Repair. Czochor JR, Sulkowski P, Glazer PM. Mol Cancer Res. 2016 Apr; 2016 Feb 5. PMID: 26850462.", + "YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors. Stachelek GC, Peterson-Roth E, Liu Y, Fernandez RJ 3rd, Pike LR, Qian JM, Abriola L, Hoyer D, Hungerford W, Merkel J, Glazer PM. Mol Cancer Res. 2015 Oct; 2015 Jun 26. PMID: 26116172.", + "Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment. Scanlon SE, Glazer PM. DNA Repair (Amst). 2015 Aug; 2015 May 1. PMID: 25956861.", + "DNA-dependent targeting of cell nuclei by a lupus autoantibody. Weisbart RH, Chan G, Jordaan G, Noble PW, Liu Y, Glazer PM, Nishimura RN, Hansen JE. Sci Rep. 2015 Jul 9; 2015 Jul 9. PMID: 26156563.", + "Tumor suppressor p53 stole the AKT in hypoxia. Yun Z, Glazer PM. J Clin Invest. 2015 Jun; 2015 May 11. PMID: 25961449.", + "Mechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines. Colis LC, Hegan DC, Kaneko M, Glazer PM, Herzon SB. J Am Chem Soc. 2015 May 6; 2015 Apr 22. PMID: 25849366.", + "Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium. McNeer NA, Anandalingam K, Fields RJ, Caputo C, Kopic S, Gupta A, Quijano E, Polikoff L, Kong Y, Bahal R, Geibel JP, Glazer PM, Saltzman WM, Egan ME. Nat Commun. 2015 Apr 27; 2015 Apr 27. PMID: 25914116.", + "Modified poly(lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung. Fields RJ, Quijano E, McNeer NA, Caputo C, Bahal R, Anandalingam K, Egan ME, Glazer PM, Saltzman WM. Adv Healthc Mater. 2015 Feb 18; 2014 Aug 25. PMID: 25156908.", + "MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, Slack FJ. Nature. 2015 Feb 5; 2014 Nov 17. PMID: 25409146.", + "LKB1 preserves genome integrity by stimulating BRCA1 expression. Gupta R, Liu AY, Glazer PM, Wajapeyee N. Nucleic Acids Res. 2015 Jan; 2014 Dec 8. PMID: 25488815.", + "Therapeutic genome mutagenesis using synthetic donor DNA and triplex-forming molecules. Reza F, Glazer PM. Methods Mol Biol. 2015. PMID: 25408401.", + "Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1. Lu Y, Wajapeyee N, Turker MS, Glazer PM. Cell Rep. 2014 Jul 24; 2014 Jul 17. PMID: 25043185.", + "microRNAs in cancer cell response to ionizing radiation. Czochor JR, Glazer PM. Antioxid Redox Signal. 2014 Jul 10; 2014 Feb 4. PMID: 24206455.", + "HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα. Zhang M, Xiang S, Joo HY, Wang L, Williams KA, Liu W, Hu C, Tong D, Haakenson J, Wang C, Zhang S, Pavlovicz RE, Jones A, Schmidt KH, Tang J, Dong H, Shan B, Fang B, Radhakrishnan R, Glazer PM, Matthias P, Koomen J, Seto E, Bepler G, Nicosia SV, Chen J, Li C, Gu L, Li GM, Bai W, Wang H, Zhang X. Mol Cell. 2014 Jul 3; 2014 May 29. PMID: 24882211.", + "Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins. Scanlon SE, Glazer PM. Mol Cancer Res. 2014 Jul; 2014 Mar 31. PMID: 24688021.", + "The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA. Colis LC, Woo CM, Hegan DC, Li Z, Glazer PM, Herzon SB. Nat Chem. 2014 Jun; 2014 May 11. PMID: 24848236.", + "Interplay between DNA repair and inflammation, and the link to cancer. Kidane D, Chae WJ, Czochor J, Eckert KA, Glazer PM, Bothwell AL, Sweasy JB. Crit Rev Biochem Mol Biol. 2014 Mar-Apr; 2014 Jan 13. PMID: 24410153.", + "Single-stranded γPNAs for in vivo site-specific genome editing via Watson-Crick recognition. Bahal R, Quijano E, McNeer NA, Liu Y, Bhunia DC, Lopez-Giraldez F, Fields RJ, Saltzman WM, Ly DH, Glazer PM. Curr Gene Ther. 2014. PMID: 25174576.", + "Targeted genome modification via triple helix formation. Ricciardi AS, McNeer NA, Anandalingam KK, Saltzman WM, Glazer PM. Methods Mol Biol. 2014. PMID: 25030921.", + "Triplex-mediated genome targeting and editing. Reza F, Glazer PM. Methods Mol Biol. 2014. PMID: 24557900.", + "Peptide nucleic acid-mediated recombination for targeted genomic repair and modification. Schleifman EB, Glazer PM. Methods Mol Biol. 2014. PMID: 24297362.", + "Hypoxia and DNA repair. Glazer PM, Hegan DC, Lu Y, Czochor J, Scanlon SE. Yale J Biol Med. 2013 Dec 13; 2013 Dec 13. PMID: 24348208.", + "Introduction. Sweasy JB, Glazer PM. Yale J Biol Med. 2013 Dec. PMID: 24498669.", + "Site-specific Genome Editing in PBMCs With PLGA Nanoparticle-delivered PNAs Confers HIV-1 Resistance in Humanized Mice. Schleifman EB, McNeer NA, Jackson A, Yamtich J, Brehm MA, Shultz LD, Greiner DL, Kumar P, Saltzman WM, Glazer PM. Mol Ther Nucleic Acids. 2013 Nov 19; 2013 Nov 19. PMID: 24253260.", + "Radiation sensitivity and sensitization in melanoma. Shahbazian D, Bindra RS, Kluger HM, Glazer PM. Pigment Cell Melanoma Res. 2013 Nov; 2013 Aug 12. PMID: 23870422.", + "Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo. McNeer NA, Schleifman EB, Cuthbert A, Brehm M, Jackson A, Cheng C, Anandalingam K, Kumar P, Shultz LD, Greiner DL, Mark Saltzman W, Glazer PM. Gene Ther. 2013 Jun; 2012 Oct 18. PMID: 23076379.", + "Nanoparticle for delivery of antisense γPNA oligomers targeting CCR5. Bahal R, McNeer NA, Ly DH, Saltzman WM, Glazer PM. Artif DNA PNA XNA. 2013 Apr-Jun. PMID: 23954968.", + "Triplex-forming peptide nucleic acids induce heritable elevations in gamma-globin expression in hematopoietic progenitor cells. Chin JY, Reza F, Glazer PM. Mol Ther. 2013 Mar; 2013 Jan 22. PMID: 23337982.", + "Hypoxia-induced protein CAIX is associated with somatic loss of BRCA1 protein and pathway activity in triple negative breast cancer. Neumeister VM, Sullivan CA, Lindner R, Lezon-Geyda K, Li J, Zavada J, Martel M, Glazer PM, Tuck DP, Rimm DL, Harris L. Breast Cancer Res Treat. 2012 Nov; 2012 Sep 14. PMID: 22976806.", + "Targeting cancer with a lupus autoantibody. Hansen JE, Chan G, Liu Y, Hegan DC, Dalal S, Dray E, Kwon Y, Xu Y, Xu X, Peterson-Roth E, Geiger E, Liu Y, Gera J, Sweasy JB, Sung P, Rockwell S, Nishimura RN, Weisbart RH, Glazer PM. Sci Transl Med. 2012 Oct 24. PMID: 23100628.", + "Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302. Meng F, Evans JW, Bhupathi D, Banica M, Lan L, Lorente G, Duan JX, Cai X, Mowday AM, Guise CP, Maroz A, Anderson RF, Patterson AV, Stachelek GC, Glazer PM, Matteucci MD, Hart CP. Mol Cancer Ther. 2012 Mar; 2011 Dec 6. PMID: 22147748.", + "Preclinical evaluation of Laromustine for use in combination with radiation therapy in the treatment of solid tumors. Rockwell S, Liu Y, Seow HA, Ishiguro K, Baumann RP, Penketh PG, Shyam K, Akintujoye OM, Glazer PM, Sartorelli AC. Int J Radiat Biol. 2012 Mar; 2011 Dec 20. PMID: 22111842.", + "Hunter Radiation Therapy Center 15 York Street PO Box 208040 New Haven, CT 06510", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Gomez Lab", + "lab_url": "https://medicine.yale.edu/lab/gomez/", + "research_bio": "INFORMATION FOR Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/gomez/publications/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Pulmonary, Critical Care & Sleep Medicine /", + "Research", + "Publications", + "Lab Members", + "Contact Us", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Publications", + "Lab Members", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Pediatric Airway Biology and Transcriptomic Assessment of Therapies. Nino G, Gomez JL, Gutierrez MJ. JAMA Pediatr. 2025 Sep 1. PMID: 40658411.", + "Cyclic GMP-AMP synthase expression is enhanced in systemic sclerosis-associated interstitial lung disease and stimulates inflammatory myofibroblast activation. Yu S, Hu B, Sun Y, Peng XY, Lee CJ, Woo S, McGovern J, Zielonka J, Saber T, Ghincea A, Gandhi S, Walia A, Pivarnik T, Ishikawa G, Shao S, Sun H, Gunes BI, Kujawski S, Perez S, Odell W, Hinchcliff M, Varga J, Feghali-Bostwick C, Sauler M, Gomez JL, Ryu C, Herzog EL. Eur Respir J. 2025 Aug; 2025 Aug 8. PMID: 40374521.", + "Down Syndrome Alters Type-III IFN and Pro-Inflammatory Airway Epithelial Responses to RSV Infection. Chorvinsky E, Bhattacharya S, Bera BS, Welham A, Ismat K, Lawlor CM, Preciado D, Gomez JL, Morizono H, Pillai DK, Gutierrez MJ, Jaiswal JK, Nino G. Am J Respir Cell Mol Biol. 2025 Jun 30; 2025 Jun 30. PMID: 40587878.", + "Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma. Kay S, Rajeevan H, Son M, Kwah J, Ramirez M, Liu Y, Wang Z, Yan X, Nino G, Britto C, Chupp G, Gomez JL. Am J Respir Cell Mol Biol. 2025 Jun 30; 2025 Jun 30. PMID: 40587876.", + "Deep Learning-based Time-to-event Analysis of Depression and Asthma using the All of Us Research Program. Wang X, Ohno-Machado L, Gomez JL, Gu W, Sun R, Kim J. AMIA Annu Symp Proc. 2024; 2025 May 22. PMID: 40417537.", + "A Nerve-Fibroblast Axis in Mammalian Lung Fibrosis. Ishikawa G, Peng X, Ghincea A, McGovern J, Zielonka J, Jeevanandam A, Shao S, Woo S, Okuno D, Yu S, Lee CJ, Liu A, Saber T, Hu B, Sun Y, Gao R, Al Jumaily K, Homer R, Hinchcliff M, Feghali-Bostwick C, Sumida TS, Sauler M, Gomez JL, Sun H, Ryu C, Herzog EL. bioRxiv. 2025 Feb 11; 2025 Feb 11. PMID: 39314391.", + "Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis. Unterman A, Zhao AY, Neumark N, Schupp JC, Ahangari F, Cosme C Jr, Sharma P, Flint J, Stein Y, Ryu C, Ishikawa G, Sumida TS, Gomez JL, Herazo-Maya JD, Dela Cruz CS, Herzog EL, Kaminski N. Am J Respir Crit Care Med. 2024 Aug 15. PMID: 38717443.", + "Deep learning prediction of hospital readmissions for asthma and COPD. Lopez K, Li H, Lipkin-Moore Z, Kay S, Rajeevan H, Davis JL, Wilson FP, Rochester CL, Gomez JL. Respir Res. 2023 Dec 13; 2023 Dec 13. PMID: 38093373.", + "Shared genetic architecture of blood eosinophil counts and asthma in UK Biobank. Li B, Wang Y, Wang Z, Li X, Kay S, Chupp GL, Zhao H, Gomez JL. ERJ Open Res. 2023 Jul; 2023 Aug 29. PMID: 37650091.", + "Single-cell profiling reveals immune aberrations in progressive idiopathic pulmonary fibrosis. Unterman A, Zhao AY, Neumark N, Schupp JC, Ahangari F, Cosme C Jr, Sharma P, Flint J, Stein Y, Ryu C, Ishikawa G, Sumida TS, Gomez JL, Herazo-Maya J, Dela Cruz CS, Herzog EL, Kaminski N. medRxiv. 2023 Apr 29; 2023 Apr 29. PMID: 37163015.", + "CD38 Mediates Lung Fibrosis by Promoting Alveolar Epithelial Cell Aging. Cui H, Xie N, Banerjee S, Dey T, Liu RM, Antony VB, Sanders YY, Adams TS, Gomez JL, Thannickal VJ, Kaminski N, Liu G. Am J Respir Crit Care Med. 2022 Aug 15. PMID: 35687485.", + "Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis. Kumar A, Elko E, Bruno SR, Mark ZF, Chamberlain N, Mihavics BK, Chandrasekaran R, Walzer J, Ruban M, Gold C, Lam YW, Ghandikota S, Jegga AG, Gomez JL, Janssen-Heininger YM, Anathy V. Thorax. 2022 Jul; 2021 Aug 16. PMID: 34400514.", + "Characterization of the COPD alveolar niche using single-cell RNA sequencing. Sauler M, McDonough JE, Adams TS, Kothapalli N, Barnthaler T, Werder RB, Schupp JC, Nouws J, Robertson MJ, Coarfa C, Yang T, Chioccioli M, Omote N, Cosme C Jr, Poli S, Ayaub EA, Chu SG, Jensen KH, Gomez JL, Britto CJ, Raredon MSB, Niklason LE, Wilson AA, Timshel PN, Kaminski N, Rosas IO. Nat Commun. 2022 Jan 25; 2022 Jan 25. PMID: 35078977.", + "SPLUNC1: a novel marker of cystic fibrosis exacerbations. Khanal S, Webster M, Niu N, Zielonka J, Nunez M, Chupp G, Slade MD, Cohn L, Sauler M, Gomez JL, Tarran R, Sharma L, Dela Cruz CS, Egan M, Laguna T, Britto CJ. Eur Respir J. 2021 Nov; 2021 Nov 11. PMID: 33958427.", + "Genes, environment, and developmental timing: New insights from translational approaches to understand early origins of respiratory diseases. Gutierrez MJ, Perez GF, Gomez JL, Rodriguez-Martinez CE, Castro-Rodriguez JA, Nino G. Pediatr Pulmonol. 2021 Oct; 2021 Aug 13. PMID: 34388306.", + "Mycobacterium abscessus complex: A Review of Recent Developments in an Emerging Pathogen. Victoria L, Gupta A, Gómez JL, Robledo J. Front Cell Infect Microbiol. 2021; 2021 Apr 26. PMID: 33981630.", + "Single-cell characterization of a model of poly I:C-stimulated peripheral blood mononuclear cells in severe asthma. Chen A, Diaz-Soto MP, Sanmamed MF, Adams T, Schupp JC, Gupta A, Britto C, Sauler M, Yan X, Liu Q, Nino G, Cruz CSD, Chupp GL, Gomez JL. Respir Res. 2021 Apr 26; 2021 Apr 26. PMID: 33902571.", + "IFN Stimulates ACE2 Expression in Pediatric Airway Epithelial Cells. Salka K, Abutaleb K, Chorvinsky E, Thiruvengadam G, Arroyo M, Gomez JL, Gutierrez MJ, Pillai DK, Jaiswal JK, Nino G. Am J Respir Cell Mol Biol. 2021 Apr. PMID: 33544656.", + "MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease. Nouws J, Wan F, Finnemore E, Roque W, Kim SJ, Bazan I, Li CX, Skold CM, Dai Q, Yan X, Chioccioli M, Neumeister V, Britto CJ, Sweasy J, Bindra R, Wheelock ÅM, Gomez JL, Kaminski N, Lee PJ, Sauler M. JCI Insight. 2021 Jan 25; 2021 Jan 25. PMID: 33290275.", + "Macrophage-derived netrin-1 drives adrenergic nerve-associated lung fibrosis. Gao R, Peng X, Perry C, Sun H, Ntokou A, Ryu C, Gomez JL, Reeves BC, Walia A, Kaminski N, Neumark N, Ishikawa G, Black KE, Hariri LP, Moore MW, Gulati M, Homer RJ, Greif DM, Eltzschig HK, Herzog EL. J Clin Invest. 2021 Jan 4. PMID: 33393489.", + "Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis. Schupp JC, Khanal S, Gomez JL, Sauler M, Adams TS, Chupp GL, Yan X, Poli S, Zhao Y, Montgomery RR, Rosas IO, Dela Cruz CS, Bruscia EM, Egan ME, Kaminski N, Britto CJ. Am J Respir Crit Care Med. 2020 Nov 15. PMID: 32603604.", + "Bioactive Plasma Mitochondrial DNA Is Associated With Disease Progression in Scleroderma-Associated Interstitial Lung Disease. Ryu C, Walia A, Ortiz V, Perry C, Woo S, Reeves BC, Sun H, Winkler J, Kanyo JE, Wang W, Vukmirovic M, Ristic N, Stratton EA, Meena SR, Minasyan M, Kurbanov D, Liu X, Lam TT, Farina G, Gomez JL, Gulati M, Herzog EL. Arthritis Rheumatol. 2020 Nov; 2020 Oct 8. PMID: 32602227.", + "A Network of Sputum MicroRNAs Is Associated with Neutrophilic Airway Inflammation in Asthma. Gomez JL, Chen A, Diaz MP, Zirn N, Gupta A, Britto C, Sauler M, Yan X, Stewart E, Santerian K, Grant N, Liu Q, Fry R, Rager J, Cohn L, Alexis N, Chupp GL. Am J Respir Crit Care Med. 2020 Jul 1. PMID: 32255668.", + "Approaches for integrating heterogeneous RNA-seq data reveal cross-talk between microbes and genes in asthmatic patients. Spakowicz D, Lou S, Barron B, Gomez JL, Li T, Liu Q, Grant N, Yan X, Hoyd R, Weinstock G, Chupp GL, Gerstein M. Genome Biol. 2020 Jun 22; 2020 Jun 22. PMID: 32571363.", + "Author Correction: Characterization of Sex-Based Dna Methylation Signatures in the Airways During Early Life. Nino CL, Perez GF, Isaza N, Gutierrez MJ, Gomez JL, Nino G. Sci Rep. 2020 Feb 26; 2020 Feb 26. PMID: 32099017.", + "An endothelial microRNA-1-regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitis. Korde A, Ahangari F, Haslip M, Zhang X, Liu Q, Cohn L, Gomez JL, Chupp G, Pober JS, Gonzalez A, Takyar SS. J Allergy Clin Immunol. 2020 Feb. PMID: 32035607.", + "Epigenetics in Asthma. Gomez JL. Curr Allergy Asthma Rep. 2019 Nov 27; 2019 Nov 27. PMID: 31776749.", + "The DNA repair transcriptome in severe COPD. Sauler M, Lamontagne M, Finnemore E, Herazo-Maya JD, Tedrow J, Zhang X, Morneau JE, Sciurba F, Timens W, Paré PD, Lee PJ, Kaminski N, Bossé Y, Gomez JL. Eur Respir J. 2018 Oct; 2018 Oct 4. PMID: 30190272.", + "Reducing protein oxidation reverses lung fibrosis. Anathy V, Lahue KG, Chapman DG, Chia SB, Casey DT, Aboushousha R, van der Velden JLJ, Elko E, Hoffman SM, McMillan DH, Jones JT, Nolin JD, Abdalla S, Schneider R, Seward DJ, Roberson EC, Liptak MD, Cousins ME, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, Ho YS, Hakem R, Brown KK, Matsui R, Bachschmid MM, Gomez JL, Kaminski N, van der Vliet A, Janssen-Heininger YMW. Nat Med. 2018 Aug; 2018 Jul 9. PMID: 29988126.", + "Characterization of Sex-Based Dna Methylation Signatures in the Airways During Early Life. Nino CL, Perez GF, Isaza N, Gutierrez MJ, Gomez JL, Nino G. Sci Rep. 2018 Apr 3; 2018 Apr 3. PMID: 29615635.", + "Impaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations. Gomez JL, Diaz MP, Nino G, Britto CJ. BMC Med Genomics. 2018 Feb 27; 2018 Feb 27. PMID: 29486764.", + "Characterisation of asthma subgroups associated with circulating YKL-40 levels. Gomez JL, Yan X, Holm CT, Grant N, Liu Q, Cohn L, Nezgovorova V, Meyers DA, Bleecker ER, Crisafi GM, Jarjour NN, Rogers L, Reibman J, Chupp GL. Eur Respir J. 2017 Oct; 2017 Oct 12. PMID: 29025889.", + "Chronic Obstructive Pulmonary Disease Readmissions and Other Measures of Hospital Quality. Rinne ST, Castaneda J, Lindenauer PK, Cleary PD, Paz HL, Gomez JL. Am J Respir Crit Care Med. 2017 Jul 1. PMID: 28145726.", + "Toward Precision Medicine of Symptom Control in Asthma. Gomez JL, Kaminski N. Am J Respir Crit Care Med. 2017 Jan 15. PMID: 28084831.", + "Airway Secretory microRNAome Changes during Rhinovirus Infection in Early Childhood. Gutierrez MJ, Gomez JL, Perez GF, Pancham K, Val S, Pillai DK, Giri M, Ferrante S, Freishtat R, Rose MC, Preciado D, Nino G. PLoS One. 2016; 2016 Sep 19. PMID: 27643599.", + "National Heart, Lung, and Blood Institute Workshop Summary: Enhancing Opportunities for Training and Retention of a Diverse Biomedical Workforce. Duncan GA, Lockett A, Villegas LR, Almodovar S, Gomez JL, Flores SC, Wilkes DS, Tigno XT. Ann Am Thorac Soc. 2016 Apr. PMID: 27058184.", + "Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40. Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N, Cohn L, Chupp GL. J Allergy Clin Immunol. 2015 Jul; 2015 Jan 13. PMID: 25592985.", + "Guillain-Barré syndrome mimics primary biliary cirrhosis-related myopathy. Munday WR, DiCapua D, Vortmeyer A, Gomez JL. Oxf Med Case Reports. 2015 Apr; 2015 Apr 23. PMID: 26634144.", + "The Anlyan Center for Medical Research & Education 300 Cedar Street New Haven, CT 06510", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Goodman Lab", + "lab_url": "https://medicine.yale.edu/lab/goodman/", + "research_bio": "INFORMATION FOR Copy Link In the gut, these microbes form a metabolic organ whose genes outnumber those in the human genome by over 100-fold, and whose composition can change overnight. It is becoming increasingly clear that variation in these communities has important consequences for health. The Goodman Lab, in theMicrobial Sciences InstituteandDepartment of Microbial Pathogenesis, works to dissect the mechanisms that commensal microbes use to compete, cooperate, and antagonize each other in the gut. We explore how microbiome variation impacts our response to external perturbations, including pathogenic infection and medical drugs. Hear about the lab's work on theNature Podcast(starts at 0m 45s). 00:03:59", + "publications_page": "https://medicine.yale.edu/lab/goodman/publications", + "publications": [ + "Yale School of Medicine /", + "Microbial Pathogenesis /", + "Home", + "News", + "Publications", + "People", + "Contact", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Home", + "Publications", + "People", + "Contact", + "News", + "", + "", + "", + "", + "", + "", + "Advanced Biosciences Center 840 West Campus Drive New Haven, CT 06516", + "Calendar", + "Contact Us", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Goodwin Lab", + "lab_url": "https://medicine.yale.edu/lab/goodwin/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/goodwin/publications/", + "publications": null + }, + { + "lab_name": "Gopal Lab", + "lab_url": "https://medicine.yale.edu/lab/gopal/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Greer Lab", + "lab_url": "https://medicine.yale.edu/lab/greer/", + "research_bio": "INFORMATION FOR A major goal of my laboratory is understanding the basic mechanisms that contribute to the establishment of orderly topographic maps within the CNS, during both normal development and during regenerative events following injury or disease. We have been focusing our efforts on the olfactory system, in part because of the complexity of the map between the olfactory epithelium and the olfactory bulb and the accessible organization of radial and horizontal synaptic circuits.. Our odor environment is complex, presenting the challenge of integrating many sensory inputs and combinatorial coding schemes. The Greer lab is committed to the implementation of developmental perspectives for understanding the organizational foundations of odor coding/representation. A primary challenge in neuroscience is understanding how choreographed events such as neurogenesis and neuroblast migration lead to the development of the complex architecture that underlies the functional specificity of functional networks. We follow the philosophy that .viewing the organization of the olfactory system through the lens of development will reveal the roadmap upon which a system is organized and acquires its specific identity. To do so we are committed to the development, acquisition and implementation of new technologies that can effectively address leading controversies within the field. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Greif Lab", + "lab_url": "https://medicine.yale.edu/lab/greif/", + "research_bio": "INFORMATION FOR Cardiovascular disease and lung disease are major causes of death globally. My laboratory utilizes multi-disciplinary approaches to investigate how blood vessels initially form, are maintained and go awry in disease. In addition, we study the role of alveolar myofibroblasts in lung development and fibrotic disease. Our research spans from cultured cells to mouse models to human samples. We aim to gain critical insights into pathogenesis of diverse cardiovascular and pulmonary pathologies and leverage these insights into novel therapeutics for human disease. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/greif/publications/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Cardiovascular Medicine /", + "Research", + "Lab Accomplishments", + "People", + "Lab Photos", + "Publications", + "Contact", + "In The News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "In The News", + "Lab Accomplishments", + "Lab Photos", + "Contact", + "", + "", + "", + "", + "", + "", + "Dave, JM, Chakraborty, R, Agyemang, A, Ntokou, A, Saito, J, Ballabh, P, Martin, KA, Greif, DM. Loss of TGFß-mediated repression of angiopoietin-2 in pericytes underlies germinal matrix hemorrhage pathogenesis. Stroke 2024.", + "Jovin, DG, Sumpio, BE, Greif, DM. Manifestations of Human Atherosclerosis Across Vascular Beds. Journal of Vascular Surgery – Vascular Insights, 2024; doi: https://doi.org/10.1016/j.jvsvi.2024.100089", + "Saddouk, FZ, Kuzemczak, A, Saito, J, Greif, DM. Pathological muscularization is maintained in pulmonary hypertension by signaling from endothelial HIFa-PDGF-B to smooth muscle Beclin1. JCI Insight 2024; 9:e162449. doi: 10.1172/jci.insight.162449 .", + "Chandran, RR, Adams, T, Kabir, I, Gallardo-Vara, E, Kaminski, N, Gomperts, B, Greif, DM. Dedifferentiated early postnatal lung myofibroblasts redifferentiate in adult disease. Frontiers in Cell and Developmental Biology, March 20, 2024; Vol 12. doi: 10.3389/fcell.2024.1335061", + "Ruz-Maldonado, I, Gonzalez, JT, Zhang, H, Sun, J, Bort, A, Kabir, I, Kibbey, RG, Suárez, Y, Greif, DM, Fernández-Hernando, C. Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage. Nature Communications 2024; 15:1247. doi: https://doi.org/10.1038/s41467-024-45439-0", + "Saito, J, Dave, JM, Lau FD, Greif, DM. Loss of presenilin-1 in smooth muscle cells ameliorates elastin aortopathy. iScience 2023; accepted on 12/1/2023.", + "Kabir, I, Zhang, X, Dave, JM, Chakraborty, R, Qu, R, Chandran, RR, Ntokou, A, Gallardo-Vara, E, Aryal, B, Rotllan, N, Garcia-Milian, R, Hwa, J, Kluger, Y, Martin, KA, Fernández-Hernando, C, Greif, DM. Age of bone marrow dictates clonality of smooth muscle cell-derived cells in the atherosclerotic plaque. Nature Aging 2023, 3:64-81. doi: 10.1038/s43587-022-00342-5 .", + "Gallardo-Vara E, Ntokou A, Dave JM, Jovin DG, Saddouk FZ, Greif DM. Vascular pathobiology of pulmonary hypertension . Journal of Heart and Lung Transplant. 2022 Dec 21:S1053-2498(22)02256-2. doi: [10.1016/j.healun.2022.12.012", + "Dave, JM, Saito, J, Mottola, G, Greif, DM. Invited chapter: Out to the tissues: the arterial side (arteries, arterioles – development, structure, functions, pathologies). In: Gallis, ZS, editor. The Vasculome: From Many, One . San Diego: Elsevier Inc./Academic Press, 2022, pp 89-98.", + "Chakraborty, R, Ostriker, AC, Xie, Y, Dave, JM, Gamez-Mendez, A, Chatterjee, P, Abu, Y, Valentine, J, Lezon-Geyda, K, Greif, DM, Schulz, V, Gallagher, PG, Sessa, W, Hwa, J and Martin, KA. (2022). The histone acetyltransferases p300 and CBP coordinate distinct chromatin remodeling programs in vascular smooth muscle plasticity. Circulation 2022; 145:1720-37. doi: 10.1161/CIRCULATIONAHA.121.057599", + "Dave, JM, Chakraborty, R, Ntokou, A, Saito, J, Saddouk, FZ, Feng, Z, Misra, A, Tellides, G, Riemer, RK, Urban, Z, Kinnear, C, Ellis, J, Mital, S., Mecham, R, Martin, KA, Greif, DM. JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency. Journal of Clinical Investigation 2022; 132(5):e142338. doi: 10.1172/JCI142338", + "Chandran RR, Xie Y, Gallardo-Vara E, Adams T, Garcia-Milian R, Kabir I, Sheikh AQ, Kaminski N, Martin KA, Herzog EL, Greif DM. Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis. Nature Communications 2021; 12:7179. doi: 10.1038/s41467-021-27499-8", + "Ntokou A, Dave JM, Kauffman AC, Sauler M, Ryu C, Hwa J, Herzog EL, Singh I, Saltzman WM, Greif DM. Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension. JCI Insight 2021; 6:139067. doi: 10.1172/jci.insight.139067", + "Gao, R, Peng, X, Perry, C, Sun, H, Ntokou, A, Ryu, C, Gomez, JL, Reeves, BC, Walia, A, Kaminski, N, Neumark, N, Ishikawa, G, Black, KE, Hariri, LP, Moore, MW, Gulati, M, Homer, RJ, Greif, DM, Eltzschig, HK, Herzog, EL. Macrophage-derived netrin-1 drives adrenergic nerve-associated lung fibrosis. Journal of Clinical Investigation 2021; 131:e136542. doi: 10.1172/JCI136542", + "Kwan, JM, Odanovic, N, Arbune, A, Higgins, A, Henry, M, Greif, D, Foss, F, Baldassarre, LA. Mogamulizumab-Associated Acute Myocarditis in a Patient With T-Cell Lymphoma. JACC: Case Reports 2021; 3:1018-23. doi: 10.1016/j.jaccas.2021.04.001", + "Chakraborthy, R, Chatterjee, P, Dave, JM, Ostriker, AC, Greif, DM, Rzucidlo, EM, Martin, KA. Targeting smooth muscle cell phenotypic switching in vascular disease. Journal of Vascular Surgery 2021, 2:79-94. doi: 10.1016/j.jvssci.2021.04.001", + "Kabir, I, Greif, DM. SNCs meet SMCs in the atherosclerotic plaque. Nature Aging 2021; 1:631-633.", + "Saddouk, FZ, Ntokou, A, Greif, DM. Invited chapter: Specialized smooth muscle cell progenitors in pulmonary hypertension. In: T. Naknishi, H. Baldwin, J. Fineman, and H. Yamagishi, editors. Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension . Springer Nature, 2020, pp 25-30.", + "Chakraborty, R, Saddouk, FZ, Carrao, AC, Krause, DS, Greif, DM, Martin, KA. Promoters to study vascular smooth muscle: mistaken identity? Arteriosclerosis, Thrombosis, and Vascular Biology 2019; 39:603-612. doi: 10.1161/ATVBAHA.119.312449", + "Ntokou, A, Kabir, I, Saddouk FZ, Greif, DM. Invited chapter: Vascular embryology and angiogenesis. In: M.A. Creager, J.A. Beckman, and J. Loscalzo, editors. Vascular Medicine, A Companion to Braunwald’s Heart Disease , 3rd edition. Philadelphia, PA: Elsevier Inc.; 2019, pp 1-16.", + "Ntokou, A, Greif, DM. (2018). Vagal nerve stimulation for pulmonary hypertension: some promise, some skepticism. Journal of the American College of Cardiology: Basic to Translational Science, 3:672.", + "Dubrac A, Kunzel, SE, Kunzel, SH, Li, J, Chandran, RR, Martin, K, Greif, DM, Adams, R, Eichmann, A. (2018) Nck-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy. Nature Communications, 9:3463.", + "Misra, A, Feng, Z, Chandran, RR, Kabir, I, Rotllan, N, Aryal, B, Sheikh, AQ, Ding, L, Qin, L, Fernandez-Hernando, C, Tellides, G, Greif, DM. (2018). Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells. Nature Communications, 9:2073. doi:10.1038/s41467.018.04447.7", + "Sheikh, AQ, Saddouk, FZ, Ntokou, A., Mazurek, R, Greif, DM. (2018) Cell autonomous and non-cell autonomous regulation of SMC progenitors in pulmonary hypertension. Cell Reports, 23:1152. doi:10.1016/j.celrep.2018.03.043", + "Ntokou, A, Kabir, I, Saddouk, FZ, Greif, DM. Invited chapter: Vascular embryology and angiogenesis. In: Vascular Medicine, A Companion to Braunwald's Heart Disease, 3rd edition. M. Creager, J. Beckham, J. Loscalzo, editors. Philadelphia, PA: Elsevier Inc., 2018, in press.", + "Dave, JM, Mirabella, T, Greif, DM. (2018) ALK5/TIMP3 axis is pericytes contributes to endothelial morphogenesis in the developing brain. Developmental Cell, 44: 665-678. doi:10.1016/j/devcel.2018.01.018", + "Greif, DM*, Eichmann, A*. (2017). Where do new endothelial cells come from in the injured heart? Nature Reviews. Cardiology, 14:507. (*Co-corresponding authors). doi:10.1038/nrcardio.2017.121", + "Misra, A, Feng, Z, Zhang, J, Lou, Z, Greif, DM. (2017). Using in vivo and tissue cell explant approaches to study morphogenesis and pathogenesis of the embryonic and perinatal aorta. Journal of Visualized Experiments, 127, e56039. doi:10.3791/56039", + "Jiao, Y, Li, G, Li, Q, Ali, R, Qin, L, Li, W, Qyang, Y, Greif, DM, Geirsson, A, Humphrey, JD and Tellides, G. (2017). mTOR inhibition decreases mechanosignaling, collagen accumulation, and stiffening of the aorta in elastin-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 37:1657-1666. https://doi.org/10.1161/ATVBAHA.117.309653", + "Mazurek, R, Dave, JM, Chandran, RR, Misra, A, Sheikh, AQ, Greif, DM. Invited chapter: Vascular cells in blood vessel development and disease. In: Raouf A. Khalil, editor. Vascular Pharmacology, Vol 78, APHA, UK: Academic Press, 2017, pp. 323-350 doi.org/10.1016/bs.apha.2016.08.001", + "Misra A, Sheikh AQ, Ding L, Kumar A, Hinton RB, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif DM. Integrin beta3 inhibition is a therapeutic strategy for supravalvular aortic stenosis. Journal of Experimental Medicine. 2016, 213:451-463. doi:10.1084/jem.20150688", + "Sheikh AQ, Misra A, Rosas IO, Adams RH, Greif DM. Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension. Science Translational Medicine. 2015, 7:308ra159. doi:10.1126/scitranslmed.aaa9712", + "Sheikh AQ, Lighthouse JK, Greif DM. Recapitulation of developing artery muscularization in pulmonary hypertension. Cell Reports. 2014, 6:809-17. doi:10.1016/j.celrep.2014.01.04", + "Seidelman S, Lighthouse JK, Greif DM. Development and pathologies of the arterial vascular wall. Cellular and Molecular Life Sciences. 2014, 71:1977-99. doi: 10.1007/s00018-013-1478-y", + "Greif DM*, Eichmann A*. Vascular biology:brain vessels squeezed to death. Nature. 2014, 508:50-1. (*Co-corresponding authors). doi:10.1038/nature13217", + "Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, McLean DL, Park H, Comhair SA, Greif DM, Erzurum SC, Chun HJ. A novel endothelial Apelin-FGF link mediated by MicroRNAs 424 and 503 is disrupted in pulmonary arterial hypertension. Nature Medicine. 2013, 19:74-82. PMC3540168", + "Greif DM. Invited chapter: Vascular embryology and angiogenesis. In: Vascular Medicine, A Companion to Braunwald's Heart Disease, 2nd edition. M. Creager, J. Beckman, J. Loscalzo, editors. Philadelphia, PA: Elsevier Inc., 2012, p. 1-13. doi:10.1016/B978-1-4377-2930-6.00001-X", + "Greif DM*, Kumar M, Lighthouse JK, Hum J, An A, Ding L, Red-horse K, Espinoza FH, Olson L, Offermanns S, Krasnow, MA*. Radial construction of an arterial wall. Developmental Cell. 2012, 23:482-93. (*Co-corresponding authors). PMC3500096", + "London NR, Zhu W, Bozza FA, Smith MC, Greif DM, Sorensen LK, Chen L, Kaminoh Y, Chan AC, Passi SF, Day CW, Barnard DL, Zimmerman GA, Krasnow MA, Li DY. Targeting Robo4-dependent slit signaling to survive the cytokine storm in sepsis and influenza. Science Translational Medicine. 2010, 23ra19. PMC2875996", + "Dudzinski DM, Igarashi J, Greif DM, Michel T. The regulation and pharmacology of endothelial nitric oxide synthase. Annual Review of Pharmacology and Toxicology. 2006, 46:235-76. doi:10.1146/annurev.pharmtox.44.101802.121844", + "SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Garcia-Cardena G, Gimbrone MA, Jain MK. KLF2 is a novel transcriptional regulator of proinflammatory activation. The Journal of Experimental Medicine. 2004, 199:1305-15. PMC2211816", + "Greif DM, Sacks DB, Michel T. Calmodulin phosphorylation and modulation of endothelial nitric oxide synthase catalysis. Proceedings of the National Academy of Sciences. 2004, 101:1165-1170. PMC337024", + "Greif DM, Kou R, Michel T. Regulation of eNOS dephosphorylation by protein phosphatase 2A: evidence for crosstalk between phosphorylation sites. Biochemistry. 2002, 41:15845-53. doi:10.1021/bio26732g", + "Kou R, Greif D, Michel, T. Dephosphorylation of endothelial nitric-oxide synthase by vascular endothelial growth factor. Implications for the vascular responses to cyclosporin A. Journal of Biological Chemistry. 2002, 277:29669-73. doi: 10.1074/jbc.M204519200", + "Goetz DJ, Greif DM, Shen J, Luscinskas FW. Cell-cell adhesive interactions in an in vitro fluid flow assay. Methods in Molecular Biology. 1999, 96:137-145. doi:10.1385/1-59259-258-9:137", + "Greif DM+, Goetz DJ+, Ding H, Camphausen RT, Howes S, Comess KM, Snapp KR, Kansas GS, Luscinskas FW. Isolated PSGL-1 dynamic adhesion to P- and E-selectin. Journal of Cell Biology. 1997, 137:509-519. (+These authors contributed equally and are listed alphabetically on publication). PMC2139768", + "Yale Cardiovascular Research Center 300 George Street New Haven, CT 06511", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Griffiths Lab", + "lab_url": "https://medicine.yale.edu/lab/griffiths/", + "research_bio": "INFORMATION FOR Copy Link Cytotoxic T lymphocytes (CTLs) play a critical role in the immune system, recognizing and destroying virally infected cells and cancer targets with remarkable specificity. These cells are extraordinarily efficient serial killers that rapidly deliver their lethal hit using precisely polarized secretion of cytolytic proteins from modified lysosomes to destroy their targets. CTLs provide a fascinating system in which to understand the cell biology of secretion in a specialized cell type. This is particularly important right now, with new immunotherapies focused on harnessing the cytotoxic potential of these cells to combat cancer. CTLs form a highly dynamic immune synapse with their targets and killing is accomplished in minutes. One reason that CTLs are so effective is because they are serial killers, killing one target after another. Using a combination of genetics, transcriptomics, biochemistry and high-resolution microscopy our research has shown how organelles including the centrosome, specialized secretory lysosomes, mitochondria and dynamic membrane changes are coordinated in response to signal strength. We have made important conceptual advances, revealing parallels between the immune synapse and cilia, demonstrating roles for common molecular pathways including Hedgehog signaling and membrane specialization. Using scRNAseq we showed that T cell receptor (TCR) signal strength controls how rapidly and simultaneously naïve T cells initiate activation, demonstrating how finite signaling machinery can further extend the range of responses generated in an immune response. We also uncovered a novel role for mitochondrial translation in controlling sustained, serial killing. More recently we showed that activated TCRs are shed by ectocytosis (outward budding) at the immune synapse rather than endocytosis (internalization) as previously thought. Ectocytosis simultaneously removes activated TCRs and initiates cell separation, seamlessly linking TCR activation with down-regulation and CTL release. Our findings suggest a model of ectosome formation that is likely to apply to many other biological systems in which outward budding vesicles are generated during receptor signaling. Our current research is focused on using multispectral and high-resolution imaging to follow the rapid reorganization of intracellular organelles, identifying polarity cues and identifying the molecular drivers of ectocytosis. We also use chimeric antigen receptor (CAR) T cells to ask why these cells are less effective killers than native CTLs and how the underlying cell biology differs. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/griffiths/publications/", + "publications": [ + "Yale School of Medicine /", + "Cell Biology /", + "People", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "People", + "Publications", + "", + "", + "", + "", + "", + "", + "Nuclear polarization to the immune synapse facilitates an early transcriptional burst Asano Y, Ma C, Limback-Stokin M, Rochussen A, Stinchcombe J, Griffiths G . Nuclear polarization to the immune synapse facilitates an early transcriptional burst . Science Immunology 2025, 10: eadt5909. PMID: 40971450 , DOI: 10.1126/sciimmunol.adt5909 . Peer-Reviewed Original Research Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Cell Membrane Cell Nucleus Imaging, Three-Dimensional Immunological Synapses Mice Mice, Inbred C57BL Mice, Transgenic Nonmuscle Myosin Type IIA T-Lymphocytes, Cytotoxic Transcription Factors Transcription, Genetic Concepts Cytotoxic T lymphocytes Target cell recognition Transcription factor translocation Immune synapse Individual cytotoxic T lymphocyte CTL-mediated killing Cell recognition Transcription factor NFAT T lymphocytes Cytolytic granules TCR activation NF-kB Nuclear polarization Transcriptional bursting De novo transcription Synapse Centrosome docking Delivery Myosin IIA Nucleus Transcription Translocation", + "Transcriptional adaptation after deletion of Cdc42 in primary T cells Rochussen A, Y. C, Griffiths G . Transcriptional adaptation after deletion of Cdc42 in primary T cells . Journal Of Cell Science 2025, 138: jcs263826. PMID: 40613419 , PMCID: PMC12377712 , DOI: 10.1242/jcs.263826 . Peer-Reviewed Original Research Citations Altmetric Concepts Transcriptional adaptation Rho family GTPases Primary T cells Nonsense-mediated decay mechanism Wild-type cells Inhibition of Cdc42 Deletion of Cdc42 Study protein function CRISPR-mediated deletion Family GTPases Rho GTPases Essential genes Cytotoxic T lymphocytes Cytoskeletal regulation Genetic compensation Polarised secretion Cdc42 deletion Protein function Cdc42 protein Cdc42 Cell polarity Promoter region Transcriptional changes Gene deletion Chemical inhibition", + "Dominant negative variants in ITPR3 impair T cell Ca2+ dynamics causing combined immunodeficiency Blanco E, Camps C, Bahal S, Kerai M, Ferla M, Rochussen A, Handel A, Golwala Z, Goncalves H, Kricke S, Klein F, Zhang F, Zinghirino F, Evans G, Keane T, Lizot S, Kusters M, Iro M, Patel S, Morris E, Burns S, Radcliffe R, Vasudevan P, Price A, Gillham O, Valdebenito G, Stewart G, Worth A, Adams S, Duchen M, André I, Adams D, Santili G, Gilmour K, Holländer G, Davies E, Taylor J, Griffiths G , Thrasher A, Dhalla F, Kreins A. Dominant negative variants in ITPR3 impair T cell Ca2+ dynamics causing combined immunodeficiency . Journal Of Experimental Medicine 2024, 222: e20220979. PMID: 39560673 , PMCID: PMC11577440 , DOI: 10.1084/jem.20220979 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Calcium Calcium Signaling Child Child, Preschool Endoplasmic Reticulum Female Humans Infant Inositol 1,4,5-Trisphosphate Receptors Male Mutation, Missense Severe Combined Immunodeficiency T-Lymphocytes Concepts Store-operated Ca2+ entry Release of ER Ca2+ Combined immunodeficiency Endoplasmic reticulum De novo missense variant Depletion of ER Ca2+ stores ER Ca2+ T cells ER Ca2+ stores Dominant negative variant Triggers store-operated Ca2+ entry Thymic T cell development Inositol 1,4,5-trisphosphate receptor T cell development T-cell lymphopenia T-cell immunodeficiency Ca2+ stores Ca2+ entry Ca2+ channels Missense variants T cell signaling Peripheral T cells Ca2+ homeostasis Negative variants Ca2+ dynamics", + "NFIL3 contributes to cytotoxic T lymphocyte-mediated killing Douanne T, Strege K, Del Castillo Velasco-Herrera M, Rochussen A, Adams D, Griffiths G . NFIL3 contributes to cytotoxic T lymphocyte-mediated killing . Open Biology 2024, 14: 230456. PMID: 38412963 , PMCID: PMC10898977 , DOI: 10.1098/rsob.230456 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords CD8-Positive T-Lymphocytes Interleukin-3 Perforin Receptors, Antigen, T-Cell T-Lymphocytes, Cytotoxic Concepts Nuclear factor IL-3 Cytotoxic T lymphocytes Naive CD8+ T cells CD8+ T cells T cell receptor T cells CD8+ cytotoxic T lymphocytes CD4+ T cells Activated cytotoxic T lymphocytes Cytotoxic T-lymphocyte-mediated killing Extracellular signal-regulated kinase phosphorylation Cell-intrinsic role Adaptive immune system Immune synapse formation Regulation of cytotoxicity Effector cytokines Natural killer CTL function T lymphocytes Immune cells Cytolytic mechanism IL-3 Proliferation changes Cancer cells Immune system", + "Cytotoxic T lymphocytes require transcription for infiltration but not target cell lysis Richard A, Y C, Marioni J, Griffiths G . Cytotoxic T lymphocytes require transcription for infiltration but not target cell lysis . EMBO Reports 2023, 24: e57653. PMID: 37860838 , PMCID: PMC10626425 , DOI: 10.15252/embr.202357653 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Cytokines Receptors, Antigen, T-Cell T-Lymphocytes, Cytotoxic Concepts Cytotoxic T lymphocytes T cell receptor T lymphocytes Release of cytolytic granules Effector cytotoxic T lymphocytes Cytotoxic T lymphocyte function Cytotoxic protein expression Target cell lysis Expression of cytokines/chemokines Cytolytic activity Actinomycin D treatment Cytolytic granules Target cells Cancer cells Transcriptional blockade Protein expression Inhibit transcription D treatment Infiltration Transcriptional requirements Cell lysis Transcriptomic changes Cells Cytokines/chemokines Expression", + "Immunodeficiency with susceptibility to lymphoma with complex genotype affecting energy metabolism (FBP1, ACAD9) and vesicle trafficking (RAB27A) Brauer N, Maruta Y, Lisci M, Strege K, Oschlies I, Nakamura H, Böhm S, Lehmberg K, Brandhoff L, Ehl S, Parvaneh N, Klapper W, Fukuda M, Griffiths G , Hennies H, Niehues T, Ammann S. Immunodeficiency with susceptibility to lymphoma with complex genotype affecting energy metabolism (FBP1, ACAD9) and vesicle trafficking (RAB27A) . Frontiers In Immunology 2023, 14: 1151166. PMID: 37388727 , PMCID: PMC10303925 , DOI: 10.3389/fimmu.2023.1151166 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Acyl-CoA Dehydrogenases Blister Energy Metabolism Genotype Humans Immunologic Deficiency Syndromes Lymphoma Primary Immunodeficiency Diseases rab27 GTP-Binding Proteins Concepts Inborn errors of immunity Hemophagocytic lymphohistiocytosis Whole-exome sequencing Immune phenotype Impairment of NK cells History of Hodgkin lymphoma Exome sequencing Griscelli syndrome type 2 Increased susceptibility to infection CD8 T cells Susceptibility to lymphoma Impaired immune regulation Errors of immunity T cell degranulation Susceptibility to infection Hodgkin lymphoma NK cells Lytic granule polarization T cells Immune regulation Critical treatment decisions Granule polarization Variable impairment Vesicle trafficking Homozygous variant", + "Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse Stinchcombe J, Asano Y, Kaufman C, Bohlig K, Peddie C, Collinson L, Nadler A, Griffiths G . Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse . Science 2023, 380: 818-823. PMID: 37228189 , PMCID: PMC7614748 , DOI: 10.1126/science.abp8933 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Cell Division Cell Membrane Cell-Derived Microparticles Diglycerides Exocytosis Immunological Synapses Receptors, Antigen, T-Cell T-Lymphocytes, Cytotoxic Concepts Cytotoxic T lymphocytes T cell receptor Immune synapse Induce negative membrane curvature Negative membrane curvature Activated T cell receptor T cell receptor signaling Target cells T cell receptor activation Self-limiting Outward budding Production of diacylglycerol Kill virus-infected Membrane curvature Ectocytosis Cancer cells T lymphocytes Diacylglycerol Ectosomes Virus infection Membrane specializations Synapse Cells Endocytosis Killing", + "Imaging the T-cell receptor: new approaches, new insights Rochussen A, Lippert A, Griffiths G . Imaging the T-cell receptor: new approaches, new insights . Current Opinion In Immunology 2023, 82: 102309. PMID: 37011462 , DOI: 10.1016/j.coi.2023.102309 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Antigen-Presenting Cells Antigens Humans Lymphocyte Activation Receptors, Antigen, T-Cell T-Lymphocytes Concepts T cell antigen receptor T cells Surface of antigen-presenting cells Antigen-presenting cells T cell activation Resting T cells T cell receptor Antigen receptor Pathogenic antigens Antigenic fragments Receptors Cellular activities Imaging techniques Imaging approach", + "Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy Trefny M, Kirchhammer N, Auf der Maur P, Natoli M, Schmid D, Germann M, Fernandez Rodriguez L, Herzig P, Lötscher J, Akrami M, Stinchcombe J, Stanczak M, Zingg A, Buchi M, Roux J, Marone R, Don L, Lardinois D, Wiese M, Jeker L, Bentires-Alj M, Rossy J, Thommen D, Griffiths G , Läubli H, Hess C, Zippelius A. Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy . Nature Communications 2023, 14: 86. PMID: 36732507 , PMCID: PMC9895440 , DOI: 10.1038/s41467-022-35583-w . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords CD8-Positive T-Lymphocytes Humans Immunotherapy Lymphocytes, Tumor-Infiltrating Neoplasms T-Cell Exhaustion Concepts T cell exhaustion T cells Tumor-specific T cells CD8 T cell exhaustion T cells in vivo Preventing T cell exhaustion Cellular cancer immunotherapy Exhausted T cells T-cell immunotherapy Anti-tumor immunity Chronic antigenic stimulation Anti-tumor efficacy T cell signaling IFNg secretion Cancer immunotherapy Memory differentiation TCR/CD28 stimulation Therapeutic options Antigenic stimulation Reduced expression CRISPR-Cas9 screens CD8 Immunotherapy Sorting nexin 9 Stimulation", + "Super‐killer CTLs are generated by single gene deletion of Bach2 Barton P, Davenport A, Hukelmann J, Cantrell D, Stinchcombe J, Richard A, Griffiths G . Super‐killer CTLs are generated by single gene deletion of Bach2 . European Journal Of Immunology 2022, 52: 1776-1788. PMID: 36086884 , PMCID: PMC9828676 , DOI: 10.1002/eji.202249797 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Basic-Leucine Zipper Transcription Factors CD8-Positive T-Lymphocytes Cytotoxicity, Immunologic Gene Deletion Granzymes Mice Perforin Proteomics T-Lymphocytes, Cytotoxic Concepts CD8+ T cells T cells Effector CTL Splenic CD8+ T cells T cell-mediated immune regulation Murine CD8+ T cells Central memory T cells Wild-type CTL Memory T cells Naive T cells Gene deletion Absence of Bach2 In vitro activity Cytolytic capacity Bach2 deficiency Naive cells Enhanced cytotoxicity Immune regulation Cytolytic granules Cytotoxic advantage CTL Bach2 Wild-type Differentiation state Granule contents", + "Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity Lisci M, Griffiths G . Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity . Trends In Cell Biology 2022, 33: 138-147. PMID: 35753961 , DOI: 10.1016/j.tcb.2022.05.007 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords CD8-Positive T-Lymphocytes Humans Lymphocyte Activation Mitochondria T-Lymphocytes, Cytotoxic Concepts CD8+ cytotoxic T lymphocytes CD8+ T cell cytotoxicity Regulation of cellular homeostasis Mitochondrial protein synthesis Stages of T cell development Study of mitochondria T cell cytotoxicity Cytotoxic T lymphocytes CTL-mediated killing T cell differentiation T cell development Mitochondrial regulation Cellular homeostasis T lymphocytes Immune cells Mitochondria Mitochondrial dysfunction Protein synthesis Immune system Homeostatic regulation Cells Intensifying interest", + "Mitochondrial translation is required for sustained killing by cytotoxic T cells Lisci M, Barton P, Randzavola L, Ma C, Marchingo J, Cantrell D, Paupe V, Prudent J, Stinchcombe J, Griffiths G . Mitochondrial translation is required for sustained killing by cytotoxic T cells . Science 2021, 374: eabe9977. PMID: 34648346 , DOI: 10.1126/science.abe9977 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Adenosine Triphosphate Animals Cell Movement Cells, Cultured Cytotoxicity, Immunologic Mice Mice, Inbred C57BL Mice, Knockout Mitochondria Mitochondrial Proteins Protein Biosynthesis T-Lymphocytes, Cytotoxic Thiolester Hydrolases Concepts Cytotoxic T lymphocytes Mitochondrial translation Sustained killing T lymphocytes Effector cytotoxic T lymphocytes Acquisition of effector functions CD8+ T lymphocytes Cytotoxic T lymphocyte killing Cytotoxic T cells T cell receptor activation Impaired mitochondrial translation Regulation of protein translation Virally infected cells Target cell-killing CTL killing T cells Mitochondrial requirements Cytosolic translation Effector functions Protein translation Cell-killing Kill cancer Killing capacity Mitochondrial depletion Homeostatic regulation", + "Staggered starts in the race to T cell activation Richard A, Frazer G, Y. C, Griffiths G . Staggered starts in the race to T cell activation . Trends In Immunology 2021, 42: 994-1008. PMID: 34649777 , PMCID: PMC7612485 , DOI: 10.1016/j.it.2021.09.004 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Cytokines Genome Humans Lymphocyte Activation T-Lymphocytes Concepts T cell activation Gene expression phenotypes Live imaging approaches Individual cell responses Expression phenotypes Stimulation strength Activated T cells Molecular studies Single-cell Molecular programs Strength of stimulation T cells T lymphocytes Population responses", + "Signal strength controls the rate of polarization within CTLs during killing Frazer G, Gawden-Bone C, Dieckmann N, Asano Y, Griffiths G . Signal strength controls the rate of polarization within CTLs during killing . Journal Of Cell Biology 2021, 220: e202104093. PMID: 34292303 , PMCID: PMC8302442 , DOI: 10.1083/jcb.202104093 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Calcium Cells, Cultured Centrosome Mice Mice, Inbred C57BL Mice, Knockout Signal Transduction Synapses T-Lymphocytes, Cytotoxic Concepts Cytotoxic T lymphocytes Proportion of cytotoxic T lymphocytes Target cells Effector CTL responses TCR signal strength Target cell recognition CTL responses Degree of killing Effector cells T lymphocytes Cytolytic granules Granule polarization Immune response Immune synapse Prolonged dwell time Kill targets Amino acid changes Cell recognition Granule delivery Acid changes Single amino acid changes Killing Cells Increasing proportion Strength of signal", + "Teasing out function from morphology: Similarities between primary cilia and immune synapses Douanne T, Stinchcombe J, Griffiths G . Teasing out function from morphology: Similarities between primary cilia and immune synapses . Journal Of Cell Biology 2021, 220: e202102089. PMID: 33956049 , PMCID: PMC8105739 , DOI: 10.1083/jcb.202102089 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Cilia Humans Immunological Synapses Signal Transduction T-Lymphocytes, Cytotoxic Concepts Cytotoxic T lymphocytes Immune synapses Cytotoxic T lymphocyte function Immune synapse Primary cilia T lymphocytes Immune cells Immune response Area of plasma membrane Centrosome polarization Polarized secretion Synapse Plasma membrane Molecular mechanisms Synapses Molecular techniques Cilia", + "Cytoskeletal control of the secretory immune synapse Douanne T, Griffiths G . Cytoskeletal control of the secretory immune synapse . Current Opinion In Cell Biology 2021, 71: 87-94. PMID: 33711784 , DOI: 10.1016/j.ceb.2021.02.008 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Actins Centrosome Cytoskeleton Immunological Synapses Synapses Concepts Immune synapse Immune cells Immune synapses Mode of secretion Actin dynamics Cytoskeletal control Interacting immune cells Coordinated fashion Transient sites Synapse Cells Secretion Centrosome Cytoskeletal Actin Synapses Diversity", + "Griscelli Syndrome Type 2 Sine Albinism: Unraveling Differential RAB27A Effector Engagement Ohishi Y, Ammann S, Ziaee V, Strege K, Groß M, Amos C, Shahrooei M, Ashournia P, Razaghian A, Griffiths G , Ehl S, Fukuda M, Parvaneh N. Griscelli Syndrome Type 2 Sine Albinism: Unraveling Differential RAB27A Effector Engagement . Frontiers In Immunology 2020, 11: 612977. PMID: 33362801 , PMCID: PMC7758216 , DOI: 10.3389/fimmu.2020.612977 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Adaptor Proteins, Signal Transducing Adolescent Albinism Animals Binding Sites Cell Line Child Child, Preschool Chlorocebus aethiops COS Cells Female Humans Infant Infant, Newborn Leukocytes, Mononuclear Lymphohistiocytosis, Hemophagocytic Male Membrane Proteins Mutation, Missense Piebaldism Primary Immunodeficiency Diseases rab GTP-Binding Proteins rab27 GTP-Binding Proteins Concepts GS-2 Rab GTPase family Regulates vesicular transport Animal cell lines GTPase family Organelle dynamics Tissue-specific effectors Vesicular transport Missense mutations Hemophagocytic lymphohistiocytosis Cellular consequences Rab27a Griscelli syndrome type 2 Episodes of hemophagocytic lymphohistiocytosis Mutations Binding sites Inborn errors of immunity Cell lines Partial albinism Errors of immunity Hair pigmentation Cytotoxic lymphocytes Clinical characteristics Inborn errors Albinism", + "A new direction for Traffic Marks M, Parton R, Schroer T, Tooze S, Brodsky F, Marsh M, Schmid S, Griffiths G , Stevens T, van Meer G. A new direction for Traffic . Traffic 2020, 21: 724-724. PMID: 33190364 , DOI: 10.1111/tra.12763 . Peer-Reviewed Original Research Citations Altmetric", + "Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling Y C, Marioni J, Griffiths G , Richard A. Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling . ELife 2020, 9: e53948. PMID: 32412411 , PMCID: PMC7308083 , DOI: 10.7554/elife.53948 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals CD8-Positive T-Lymphocytes Cells, Cultured Female Flow Cytometry Interferon Regulatory Factors Kinetics Ligands Lymphocyte Activation Male Mice, Inbred C57BL Mice, Transgenic Nuclear Receptor Subfamily 4, Group A, Member 1 Ovalbumin Peptide Fragments Phosphorylation Receptors, Antigen, T-Cell Ribosomal Protein S6 Signal Transduction Single-Cell Analysis Concepts T cells Murine CD8+ T cells Strength of TCR stimulation CD8+ T cells Distal signaling events Stimulation strength TCR-induced signals Naive T cells Multiple signaling pathways T cell activation Ribosomal protein S6 Signaling events Peptide-MHC ligands Intracellular machinery TCR stimulation Protein S6 Signaling pathway Mass cytometry Signaling results Stimulation Molecular organization Transcription", + "Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy Huhn O, Ivarsson M, Gardner L, Hollinshead M, Stinchcombe J, Chen P, Shreeve N, Chazara O, Farrell L, Theorell J, Ghadially H, Parham P, Griffiths G , Horowitz A, Moffett A, Sharkey A, Colucci F. Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy . Nature Communications 2020, 11: 381. PMID: 31959757 , PMCID: PMC6971012 , DOI: 10.1038/s41467-019-14123-z . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Cell Communication Chemokines, C Decidua Dendritic Cells Female Histocompatibility Antigens Class I Humans Immunity, Innate K562 Cells Killer Cells, Natural Lymphocyte Activation Lymphocyte Subsets Mice Placentation Pregnancy Receptors, KIR Trophoblasts Concepts Decidual innate lymphoid cells Killer-cell immunoglobulin-like receptors Fetal extravillous trophoblasts Innate lymphoid cells Extravillous trophoblast NK cells Early pregnancy Lymphoid cells Function of innate lymphoid cells Peripheral blood NK cells HLA class I ligands Maternal dendritic cells Blood NK cells Decidual NK cells Granzyme B levels Proliferating NK cells Immunoglobulin-like receptors Class I ligands Increased chemokine production Decidual NK Human decidua Maternal cells Dendritic cells Placental development Chemokine production", + "High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation Abeler-Dörner L, Laing A, Lorenc A, Ushakov D, Clare S, Speak A, Duque-Correa M, White J, Ramirez-Solis R, Saran N, Bull K, Morón B, Iwasaki J, Barton P, Caetano S, Hng K, Cambridge E, Forman S, Crockford T, Griffiths M, Kane L, Harcourt K, Brandt C, Notley G, Babalola K, Warren J, Mason J, Meeniga A, Karp N, Melvin D, Cawthorne E, Weinrick B, Rahim A, Drissler S, Meskas J, Yue A, Lux M, Song-Zhao G, Chan A, Ballesteros Reviriego C, Abeler J, Wilson H, Przemska-Kosicka A, Edmans M, Strevens N, Pasztorek M, Meehan T, Powrie F, Brinkman R, Dougan G, Jacobs W, Lloyd C, Cornall R, Maloy K, Grencis R, Griffiths G , Adams D, Hayday A. High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation . Nature Immunology 2019, 21: 86-100. PMID: 31844327 , PMCID: PMC7338221 , DOI: 10.1038/s41590-019-0549-0 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Citrobacter Enterobacteriaceae Infections Female Genetic Variation High-Throughput Screening Assays Humans Immunophenotyping Male Mice Mice, Inbred C57BL Mice, Knockout Models, Animal Salmonella Salmonella Infections Concepts High-throughput genetic screens Immune variation High-throughput phenotyping Mouse gene knockouts Associated with immunocompetence Genetic screening Loss of function Contribution of genetics Physiological traits Genetic resources Gene knockout Individual immune parameters Immune parameters Correlation network Phenotype Immunological structure Tolerance to loss Genes Hits Genetics Structural underpinnings Traits Knockout Structural perspective Variation", + "Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity Randzavola L, Strege K, Juzans M, Asano Y, Stinchcombe J, Gawden-Bone C, Seaman M, Kuijpers T, Griffiths G . Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity . Journal Of Clinical Investigation 2019, 129: 5600-5614. PMID: 31710310 , PMCID: PMC6877333 , DOI: 10.1172/jci129388 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Actin-Related Protein 2-3 Complex Actins CD8 Antigens Cell Polarity Cytotoxicity, Immunologic Glucose Transporter Type 1 HEK293 Cells Humans Immunological Synapses Lymphocyte Activation Receptors, Antigen, T-Cell, alpha-beta T-Lymphocytes, Cytotoxic Concepts CD8 cytotoxic T lymphocytes Loss of CD8+ T cells CD8+ T cell counts CD8+ T cells Viral infection Symptoms of immune dysregulation T-cell counts Recurrent viral infections Prolonged viral infection Cytotoxic T lymphocytes F-actin Adaptive immune responses Secretion of lytic granules Actin-related protein 2/3 Polarized secretion of lytic granules T cell signaling Target cell death CTL cytotoxicity CTL activity F-actin network Combined immunodeficiency Immune dysregulation T cells Cytolytic activity T lymphocytes", + "Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse Gawden-Bone C, Griffiths G . Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse . Frontiers In Immunology 2019, 10: 700. PMID: 31031745 , PMCID: PMC6470250 , DOI: 10.3389/fimmu.2019.00700 . Peer-Reviewed Original Research Citations MeSH Keywords and Concepts MeSH Keywords Actins Cilia Cytoplasmic Granules Cytoskeleton Humans Immunological Synapses Metabolic Networks and Pathways Phospholipids Signal Transduction T-Lymphocytes, Cytotoxic Concepts Immune synapse Plasma membrane Signaling events Phospholipid phosphatidylserine Inner leaflet Phosphatidic acid Cellular responses Granule delivery Cell function Immune cell function Extracellular changes Function of cytotoxic T lymphocytes Membrane changes Cytotoxic T lymphocytes Membrane Synapse Cytoskeleton T lymphocytes Actin Phosphoinositide Diacylglycerol Phosphatidylserine Messenger", + "PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes Gawden-Bone C, Frazer G, Richard A, Y. C, Strege K, Griffiths G . PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes . Immunity 2018, 49: 427-437.e4. PMID: 30217409 , PMCID: PMC6162341 , DOI: 10.1016/j.immuni.2018.08.017 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Actins Animals Cell Degranulation Cell Line Cell Membrane Cytoplasmic Granules Cytotoxicity, Immunologic Immunological Synapses Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Transgenic Phosphatidylinositols Phosphotransferases (Alcohol Group Acceptor) Receptors, Antigen, T-Cell Signal Transduction T-Lymphocytes, Cytotoxic Concepts Plasma membrane Granule secretion Synapse formation T cell receptor Area of plasma membrane T cell receptor signaling Immune synapse formation Actin depletion Actin recruitment Phosphoinositide composition PIP5-kinase Cytotoxic T lymphocytes Membrane phosphoinositides PI(4,5)P2 Centrosome docking Actin TCR activation Cell receptors Increased diacylglycerol Phosphoinositide Synapse Diacylglycerol Force localization Secretion Membrane", + "T cell cytolytic capacity is independent of initial stimulation strength Richard A, Lun A, Lau W, Göttgens B, Marioni J, Griffiths G . T cell cytolytic capacity is independent of initial stimulation strength . Nature Immunology 2018, 19: 849-858. PMID: 30013148 , PMCID: PMC6300116 , DOI: 10.1038/s41590-018-0160-9 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals CD8-Positive T-Lymphocytes Cell Line Cytotoxicity, Immunologic Genome Lymphocyte Activation Mice Mice, Inbred C57BL Receptors, Antigen, T-Cell, alpha-beta RNA Signal Transduction Single-Cell Analysis Concepts Genome-wide RNA Signaling machinery Intercellular variability Transcriptional pathways Environmental fluctuations Myriad stimuli Ligand potency CD8+ T cells in vitro Activation pathway Single cells T cells in vitro Naive T cells Machinery Active cells Cells Stimulation strength Pathway Cytolytic capacity T cells RNA Activity Protein Phenotype", + "", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Groisman Lab", + "lab_url": "https://medicine.yale.edu/lab/groisman/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/groisman/publications", + "publications": [ + "Yale School of Medicine /", + "Microbial Pathogenesis /", + "Research", + "Join the Lab!", + "People", + "News", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "News", + "Publications", + "Join the Lab!", + "", + "", + "", + "", + "", + "", + "How Pathogens Maintain Proteostasis During Infection. Chan C, Groisman EA. Mol Microbiol. 2025 Nov 4; 2025 Nov 4. PMID: 41186155.", + "Hierarchical glycolytic pathways control the carbohydrate utilization regulator in human gut Bacteroides. Kabonick SG, Verma K, Modesto JL, Pearce VH, Winokur KM, Groisman EA, Townsend GE 2nd. Nat Commun. 2025 May 14; 2025 May 14. PMID: 40368925.", + "Infection-relevant conditions dictate differential versus coordinate expression of Salmonella chaperones and cochaperones. Chan C, Mukai K, Groisman EA. mBio. 2025 May 14; 2025 Mar 31. PMID: 40162747.", + "Hierarchical glycolytic pathways control the carbohydrate utilization regulator in human gut Bacteroides. Kabonick SG, Verma K, Modesto JL, Pearce VH, Winokur KM, Groisman EA, Townsend GE. bioRxiv. 2025 Apr 2; 2025 Apr 2. PMID: 39605394.", + "Cytoplasmic Mg(2+) supersedes carbon source preference to dictate Salmonella metabolism. Pokorzynski ND, Jones KA, Campagna SR, Groisman EA. Proc Natl Acad Sci U S A. 2025 Apr; 2025 Mar 25. PMID: 40131949.", + "Chaperone Hsp70 helps Salmonella survive infection-relevant stress by reducing protein synthesis. Chan C, Groisman EA. PLoS Biol. 2024 Apr; 2024 Apr 4. PMID: 38574172.", + "Correction for Duprey and Groisman, \"FEDS: a Novel Fluorescence-Based High-Throughput Method for Measuring DNA Supercoiling In Vivo\". Duprey A, Groisman EA. mBio. 2024 Jan 16; 2023 Dec 7. PMID: 38059645.", + "Advancing the fitness of gut commensal bacteria. Groisman EA, Han W, Krypotou E. Science. 2023 Nov 17; 2023 Nov 16. PMID: 37972163.", + "Advancing evolution: Bacteria break down gene silencer to express horizontally acquired genes. Groisman EA, Choi J. Bioessays. 2023 Oct; 2023 Aug 3. PMID: 37533411.", + "How Bacterial Pathogens Coordinate Appetite with Virulence. Pokorzynski ND, Groisman EA. Microbiol Mol Biol Rev. 2023 Sep 26; 2023 Jun 26. PMID: 37358444.", + "Bacteria require phase separation for fitness in the mammalian gut. Krypotou E, Townsend GE, Gao X, Tachiyama S, Liu J, Pokorzynski ND, Goodman AL, Groisman EA. Science. 2023 Mar 17; 2023 Mar 16. PMID: 36927025.", + "Gut colonization by Bacteroides requires translation by an EF-G paralog lacking GTPase activity. Han W, Peng BZ, Wang C, Townsend GE 2nd, Barry NA, Peske F, Goodman AL, Liu J, Rodnina MV, Groisman EA. EMBO J. 2023 Jan 16; 2022 Dec 6. PMID: 36472247.", + "Dietary sugars silence the master regulator of carbohydrate utilization in human gut Bacteroides species. Pearce VH, Groisman EA, Townsend GE 2nd. Gut Microbes. 2023 Jan-Dec. PMID: 37358144.", + "Degradation of gene silencer is essential for expression of foreign genes and bacterial colonization of the mammalian gut. Choi J, Schmukler M, Groisman EA. Proc Natl Acad Sci U S A. 2022 Oct 4; 2022 Sep 26. PMID: 36161931.", + "Differential synthesis of novel small protein times Salmonella virulence program. Salvail H, Choi J, Groisman EA. PLoS Genet. 2022 Mar; 2022 Mar 4. PMID: 35245279.", + "RNA chaperone activates Salmonella virulence program during infection. Choi J, Salvail H, Groisman EA. Nucleic Acids Res. 2021 Nov 18. PMID: 34751407.", + "Cellular Adaptations to Cytoplasmic Mg(2+) Limitation. Groisman EA, Chan C. Annu Rev Microbiol. 2021 Oct 8. PMID: 34623895.", + "The regulation of DNA supercoiling across evolution. Duprey A, Groisman EA. Protein Sci. 2021 Oct; 2021 Aug 23. PMID: 34398513.", + "How the PhoP/PhoQ System Controls Virulence and Mg(2+) Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution. Groisman EA, Duprey A, Choi J. Microbiol Mol Biol Rev. 2021 Aug 18; 2021 Jun 30. PMID: 34191587.", + "The Practice of Science as the Pursuit of Knowledge. Groisman EA. Yale J Biol Med. 2021 Jun; 2021 Jun 30. PMID: 34211357.", + "Low Cytoplasmic Magnesium Increases the Specificity of the Lon and ClpAP Proteases. Yeom J, Groisman EA. J Bacteriol. 2021 Jun 22; 2021 Jun 22. PMID: 33941609.", + "Limitation of phosphate assimilation maintains cytoplasmic magnesium homeostasis. Bruna RE, Kendra CG, Groisman EA, Pontes MH. Proc Natl Acad Sci U S A. 2021 Mar 16. PMID: 33707210.", + "How Pathogens Feel and Overcome Magnesium Limitation When in Host Tissues. Blanc-Potard AB, Groisman EA. Trends Microbiol. 2021 Feb; 2020 Aug 14. PMID: 32807623.", + "Reduced ATP-dependent proteolysis of functional proteins during nutrient limitation speeds the return of microbes to a growth state. Yeom J, Groisman EA. Sci Signal. 2021 Jan 26; 2021 Jan 26. PMID: 33500334.", + "Horizontally acquired regulatory gene activates ancestral regulatory system to promote Salmonella virulence. Choi J, Groisman EA. Nucleic Acids Res. 2020 Nov 4. PMID: 33045730.", + "DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines. Duprey A, Groisman EA. PLoS Genet. 2020 Oct; 2020 Oct 30. PMID: 33125364.", + "Small proteins regulate Salmonella survival inside macrophages by controlling degradation of a magnesium transporter. Yeom J, Shao Y, Groisman EA. Proc Natl Acad Sci U S A. 2020 Aug 18; 2020 Aug 4. PMID: 32753384.", + "FEDS: a Novel Fluorescence-Based High-Throughput Method for Measuring DNA Supercoiling In Vivo. Duprey A, Groisman EA. mBio. 2020 Jul 28; 2020 Jul 28. PMID: 32723920.", + "A Physiological Basis for Nonheritable Antibiotic Resistance. Pontes MH, Groisman EA. mBio. 2020 Jun 16; 2020 Jun 16. PMID: 32546621.", + "The phosphorelay BarA/SirA activates the non-cognate regulator RcsB in Salmonella enterica. Salvail H, Groisman EA. PLoS Genet. 2020 May; 2020 May 11. PMID: 32392214.", + "Salmonella expresses foreign genes during infection by degrading their silencer. Choi J, Groisman EA. Proc Natl Acad Sci U S A. 2020 Apr 7; 2020 Mar 24. PMID: 32209674.", + "Erratum for Townsend et al., \"A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor\". Townsend GE 2nd, Han W, Schwalm ND 3rd, Hong X, Bencivenga-Barry NA, Goodman AL, Groisman EA. mBio. 2020 Mar 17; 2020 Mar 17. PMID: 32184244.", + "A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor. Townsend GE 2nd, Han W, Schwalm ND 3rd, Hong X, Bencivenga-Barry NA, Goodman AL, Groisman EA. mBio. 2020 Jan 28; 2020 Jan 28. PMID: 31992627.", + "The expanded specificity and physiological role of a widespread N-degron recognin. Gao X, Yeom J, Groisman EA. Proc Natl Acad Sci U S A. 2019 Sep 10; 2019 Aug 26. PMID: 31451664.", + "Activator of one protease transforms into inhibitor of another in response to nutritional signals. Yeom J, Groisman EA. Genes Dev. 2019 Sep 1; 2019 Aug 1. PMID: 31371438.", + "Slow growth determines nonheritable antibiotic resistance in Salmonella enterica. Pontes MH, Groisman EA. Sci Signal. 2019 Jul 30; 2019 Jul 30. PMID: 31363068.", + "Dietary sugar silences a colonization factor in a mammalian gut symbiont. Townsend GE 2nd, Han W, Schwalm ND 3rd, Raghavan V, Barry NA, Goodman AL, Groisman EA. Proc Natl Acad Sci U S A. 2019 Jan 2; 2018 Dec 17. PMID: 30559205.", + "A protein that controls the onset of a Salmonella virulence program. Yeom J, Pontes MH, Choi J, Groisman EA. EMBO J. 2018 Jul 13; 2018 Jun 1. PMID: 29858228.", + "Gene expression kinetics governs stimulus-specific decoration of the Salmonella outer membrane. Hong X, Chen HD, Groisman EA. Sci Signal. 2018 May 8; 2018 May 8. PMID: 29739882.", + "Reduction in adaptor amounts establishes degradation hierarchy among protease substrates. Yeom J, Gao X, Groisman EA. Proc Natl Acad Sci U S A. 2018 May 8; 2018 Apr 23. PMID: 29686082.", + "Protein synthesis controls phosphate homeostasis. Pontes MH, Groisman EA. Genes Dev. 2018 Jan 1; 2018 Feb 1. PMID: 29437726.", + "Navigating the Gut Buffet: Control of Polysaccharide Utilization in Bacteroides spp. Schwalm ND 3rd, Groisman EA. Trends Microbiol. 2017 Dec; 2017 Jul 18. PMID: 28733133.", + "Activation of master virulence regulator PhoP in acidic pH requires the Salmonella-specific protein UgtL. Choi J, Groisman EA. Sci Signal. 2017 Aug 29; 2017 Aug 29. PMID: 28851823.", + "Sequestration from Protease Adaptor Confers Differential Stability to Protease Substrate. Yeom J, Wayne KJ, Groisman EA. Mol Cell. 2017 Apr 20. PMID: 28431231.", + "Prioritization of polysaccharide utilization and control of regulator activation in Bacteroides thetaiotaomicron. Schwalm ND 3rd, Townsend GE 2nd, Groisman EA. Mol Microbiol. 2017 Apr; 2017 Feb 3. PMID: 28009067.", + "RNA secondary structures regulate three steps of Rho-dependent transcription termination within a bacterial mRNA leader. Kriner MA, Groisman EA. Nucleic Acids Res. 2017 Jan 25; 2016 Oct 5. PMID: 28123036.", + "Reducing Ribosome Biosynthesis Promotes Translation during Low Mg(2+) Stress. Pontes MH, Yeom J, Groisman EA. Mol Cell. 2016 Nov 3; 2016 Oct 13. PMID: 27746019.", + "Multiple Signals Govern Utilization of a Polysaccharide in the Gut Bacterium Bacteroides thetaiotaomicron. Schwalm ND 3rd, Townsend GE 2nd, Groisman EA. mBio. 2016 Oct 11; 2016 Oct 11. PMID: 27729509.", + "Feedback Control of Two-Component Regulatory Systems. Groisman EA. Annu Rev Microbiol. 2016 Sep 8. PMID: 27607549.", + "Acidic pH sensing in the bacterial cytoplasm is required for Salmonella virulence. Choi J, Groisman EA. Mol Microbiol. 2016 Sep; 2016 Jul 8. PMID: 27282333.", + "Learning from the Leaders: Gene Regulation by the Transcription Termination Factor Rho. Kriner MA, Sevostyanova A, Groisman EA. Trends Biochem Sci. 2016 Aug; 2016 Jun 17. PMID: 27325240.", + "An RNA motif advances transcription by preventing Rho-dependent termination. Sevostyanova A, Groisman EA. Proc Natl Acad Sci U S A. 2015 Dec 15; 2015 Nov 16. PMID: 26630006.", + "The Bacterial Transcription Termination Factor Rho Coordinates Mg(2+) Homeostasis with Translational Signals. Kriner MA, Groisman EA. J Mol Biol. 2015 Dec 4; 2015 Oct 30. PMID: 26523680.", + "When Too Much ATP Is Bad for Protein Synthesis. Pontes MH, Sevostyanova A, Groisman EA. J Mol Biol. 2015 Aug 14; 2015 Jul 4. PMID: 26150063.", + "Species-specific dynamic responses of gut bacteria to a mammalian glycan. Raghavan V, Groisman EA. J Bacteriol. 2015 May; 2015 Feb 17. PMID: 25691527.", + "Salmonella promotes virulence by repressing cellulose production. Pontes MH, Lee EJ, Choi J, Groisman EA. Proc Natl Acad Sci U S A. 2015 Apr 21; 2015 Apr 6. PMID: 25848006.", + "Flagella-independent surface motility in Salmonella enterica serovar Typhimurium. Park SY, Pontes MH, Groisman EA. Proc Natl Acad Sci U S A. 2015 Feb 10; 2015 Jan 26. PMID: 25624475.", + "Bacterial nucleoid-associated protein uncouples transcription levels from transcription timing. Zwir I, Yeo WS, Shin D, Latifi T, Huang H, Groisman EA. mBio. 2014 Oct 7; 2014 Oct 7. PMID: 25293763.", + "Tuning transcription of nutrient utilization genes to catabolic rate promotes growth in a gut bacterium. Raghavan V, Lowe EC, Townsend GE 2nd, Bolam DN, Groisman EA. Mol Microbiol. 2014 Sep; 2014 Aug 12. PMID: 25041429.", + "Unusually long-lived pause required for regulation of a Rho-dependent transcription terminator. Hollands K, Sevostiyanova A, Groisman EA. Proc Natl Acad Sci U S A. 2014 May 13; 2014 Apr 28. PMID: 24778260.", + "Control of a Salmonella virulence operon by proline-charged tRNA(Pro). Lee EJ, Choi J, Groisman EA. Proc Natl Acad Sci U S A. 2014 Feb 25; 2014 Feb 10. PMID: 24516160.", + "Signal-specific temporal response by the Salmonella PhoP/PhoQ regulatory system. Park SY, Groisman EA. Mol Microbiol. 2014 Jan; 2013 Nov 20. PMID: 24256574.", + "A bacterial virulence protein promotes pathogenicity by inhibiting the bacterium's own F1Fo ATP synthase. Lee EJ, Pontes MH, Groisman EA. Cell. 2013 Jul 3. PMID: 23827679.", + "The lipopolysaccharide modification regulator PmrA limits Salmonella virulence by repressing the type three-secretion system Spi/Ssa. Choi J, Groisman EA. Proc Natl Acad Sci U S A. 2013 Jun 4; 2013 May 20. PMID: 23690578.", + "Conflicting roles for a cell surface modification in Salmonella. May JF, Groisman EA. Mol Microbiol. 2013 Jun; 2013 May 5. PMID: 23646936.", + "Intramolecular arrangement of sensor and regulator overcomes relaxed specificity in hybrid two-component systems. Townsend GE 2nd, Raghavan V, Zwir I, Groisman EA. Proc Natl Acad Sci U S A. 2013 Jan 8; 2012 Dec 19. PMID: 23256153.", + "Bacterial Mg2+ homeostasis, transport, and virulence. Groisman EA, Hollands K, Kriner MA, Lee EJ, Park SY, Pontes MH. Annu Rev Genet. 2013; 2013 Sep 20. PMID: 24079267.", + "The biology of the PmrA/PmrB two-component system: the major regulator of lipopolysaccharide modifications. Chen HD, Groisman EA. Annu Rev Microbiol. 2013; 2013 Jun 17. PMID: 23799815.", + "Expression of STM4467-encoded arginine deiminase controlled by the STM4463 regulator contributes to Salmonella enterica serovar Typhimurium virulence. Choi Y, Choi J, Groisman EA, Kang DH, Shin D, Ryu S. Infect Immun. 2012 Dec; 2012 Sep 24. PMID: 23006851.", + "Tandem attenuators control expression of the Salmonella mgtCBR virulence operon. Lee EJ, Groisman EA. Mol Microbiol. 2012 Oct; 2012 Aug 26. PMID: 22857388.", + "Reciprocal control between a bacterium's regulatory system and the modification status of its lipopolysaccharide. Kato A, Chen HD, Latifi T, Groisman EA. Mol Cell. 2012 Sep 28; 2012 Aug 23. PMID: 22921935.", + "Control of a Salmonella virulence locus by an ATP-sensing leader messenger RNA. Lee EJ, Groisman EA. Nature. 2012 Jun 13; 2012 Jun 13. PMID: 22699622.", + "Inhibition of bacterial virulence: drug-like molecules targeting the Salmonella enterica PhoP response regulator. Tang YT, Gao R, Havranek JJ, Groisman EA, Stock AM, Marshall GR. Chem Biol Drug Des. 2012 Jun; 2012 Mar 21. PMID: 22339993.", + "The promoter architectural landscape of the Salmonella PhoP regulon. Zwir I, Latifi T, Perez JC, Huang H, Groisman EA. Mol Microbiol. 2012 May; 2012 Mar 27. PMID: 22435712.", + "Riboswitch control of Rho-dependent transcription termination. Hollands K, Proshkin S, Sklyarova S, Epshtein V, Mironov A, Nudler E, Groisman EA. Proc Natl Acad Sci U S A. 2012 Apr 3; 2012 Mar 19. PMID: 22431636.", + "Intrinsic negative feedback governs activation surge in two-component regulatory systems. Yeo WS, Zwir I, Huang HV, Shin D, Kato A, Groisman EA. Mol Cell. 2012 Feb 10. PMID: 22325356.", + "An allele of an ancestral transcription factor dependent on a horizontally acquired gene product. Chen HD, Jewett MW, Groisman EA. PLoS Genet. 2012; 2012 Dec 27. PMID: 23300460.", + "Genome-wide detection of novel regulatory RNAs in E. coli. Raghavan R, Groisman EA, Ochman H. Genome Res. 2011 Sep; 2011 Jun 10. PMID: 21665928.", + "Ancestral genes can control the ability of horizontally acquired loci to confer new traits. Chen HD, Jewett MW, Groisman EA. PLoS Genet. 2011 Jul; 2011 Jul 21. PMID: 21811415.", + "A bacterial mRNA leader that employs different mechanisms to sense disparate intracellular signals. Park SY, Cromie MJ, Lee EJ, Groisman EA. Cell. 2010 Sep 3. PMID: 20813261.", + "Positive autoregulation shapes response timing and intensity in two-component signal transduction systems. Mitrophanov AY, Hadley TJ, Groisman EA. J Mol Biol. 2010 Aug 27; 2010 Jun 30. PMID: 20600106.", + "Defining the plasticity of transcription factor binding sites by Deconstructing DNA consensus sequences: the PhoP-binding sites among gamma/enterobacteria. Harari O, Park SY, Huang H, Groisman EA, Zwir I. PLoS Comput Biol. 2010 Jul 22; 2010 Jul 22. PMID: 20661307.", + "An antisense RNA that governs the expression kinetics of a multifunctional virulence gene. Lee EJ, Groisman EA. Mol Microbiol. 2010 May; 2010 Apr 14. PMID: 20398218.", + "Orphan and hybrid two-component system proteins in health and disease. Raghavan V, Groisman EA. Curr Opin Microbiol. 2010 Apr; 2010 Jan 19. PMID: 20089442.", + "Response acceleration in post-translationally regulated genetic circuits. Mitrophanov AY, Groisman EA. J Mol Biol. 2010 Mar 12; 2009 Nov 20. PMID: 19932119.", + "Promoter and riboswitch control of the Mg2+ transporter MgtA from Salmonella enterica. Cromie MJ, Groisman EA. J Bacteriol. 2010 Jan; 2009 Nov 6. PMID: 19897653.", + "Short-term signatures of evolutionary change in the Salmonella enterica serovar typhimurium 14028 genome. Jarvik T, Smillie C, Groisman EA, Ochman H. J Bacteriol. 2010 Jan; 2009 Nov 6. PMID: 19897643.", + "Activated by different signals, the PhoP/PhoQ two-component system differentially regulates metal uptake. Choi E, Groisman EA, Shin D. J Bacteriol. 2009 Dec; 2009 Oct 2. PMID: 19801407.", + "Evolution of transcriptional regulatory circuits in bacteria. Perez JC, Groisman EA. Cell. 2009 Jul 23. PMID: 19632175.", + "Identifying promoter features of co-regulated genes with similar network motifs. Harari O, del Val C, Romero-Zaliz R, Shin D, Huang H, Groisman EA, Zwir I. BMC Bioinformatics. 2009 Apr 29; 2009 Apr 29. PMID: 19426448.", + "Control of Salmonella pathogenicity island-2 gene expression. Fass E, Groisman EA. Curr Opin Microbiol. 2009 Apr; 2009 Mar 4. PMID: 19264535.", + "Transcription factor function and promoter architecture govern the evolution of bacterial regulons. Perez JC, Groisman EA. Proc Natl Acad Sci U S A. 2009 Mar 17; 2009 Feb 27. PMID: 19251636.", + "Evolution of a bacterial regulon controlling virulence and Mg(2+) homeostasis. Perez JC, Shin D, Zwir I, Latifi T, Hadley TJ, Groisman EA. PLoS Genet. 2009 Mar; 2009 Mar 20. PMID: 19300486.", + "RstA-promoted expression of the ferrous iron transporter FeoB under iron-replete conditions enhances Fur activity in Salmonella enterica. Jeon J, Kim H, Yun J, Ryu S, Groisman EA, Shin D. J Bacteriol. 2008 Nov; 2008 Sep 12. PMID: 18790861.", + "Evolution and dynamics of regulatory architectures controlling polymyxin B resistance in enteric bacteria. Mitrophanov AY, Jewett MW, Hadley TJ, Groisman EA. PLoS Genet. 2008 Oct; 2008 Oct 24. PMID: 18949034.", + "Signal integration in bacterial two-component regulatory systems. Mitrophanov AY, Groisman EA. Genes Dev. 2008 Oct 1. PMID: 18832064.", + "Positive feedback in cellular control systems. Mitrophanov AY, Groisman EA. Bioessays. 2008 Jun. PMID: 18478531.", + "Overcoming H-NS-mediated transcriptional silencing of horizontally acquired genes by the PhoP and SlyA proteins in Salmonella enterica. Perez JC, Latifi T, Groisman EA. J Biol Chem. 2008 Apr 18; 2008 Feb 11. PMID: 18270203.", + "The PhoQ/PhoP regulatory network of Salmonella enterica. Kato A, Groisman EA. Adv Exp Med Biol. 2008. PMID: 18792679.", + "A connector of two-component regulatory systems promotes signal amplification and persistence of expression. Kato A, Mitrophanov AY, Groisman EA. Proc Natl Acad Sci U S A. 2007 Jul 17; 2007 Jul 5. PMID: 17615238.", + "", + "Contact Us", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Gruen Lab", + "lab_url": "https://medicine.yale.edu/lab/gruen/", + "research_bio": "INFORMATION FOR Our lab studies the genetics of communication disorders and learning disabilities, specifically dyslexia and developmental language disorder. Dyslexia or reading disability (RD) is by far the most common learning disability in schoolchildren, with prevalence estimates ranging from 5-17%. Children with dyslexia are frequently undiagnosed, misdiagnosed, or not diagnosed until school age. By then, educational interventions available are not as effective, since interventions are most successful when started early in development (prior to school age). Without proper remediation, affected children are at higher risk for adverse socioeconomic outcomes, poor academic performance, lowered self-esteem, and lifelong struggles with basic linguistic skills. Little is known about the underlying biological etiology of dyslexia and language impairment. However, heritability estimates for both dyslexia and language impairment range from 40% - 80% indicating a substantial genetic component but with a complex pattern of inheritance. The premise of the lab is to use a combination of statistical genetics, neuroimaging, and molecular tools to examine the biological underpinnings of dyslexia, developmental language disorder, and other learning disabilities. We are actively seeking talented and motivated graduate students and postdoctoral researchers to join our research group. Interested candidates should send a brief description of research background/interests and curriculum vitae toDr. Jeffrey Gruen. Copy Link Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Grutzendler Lab", + "lab_url": "https://medicine.yale.edu/lab/grutzendler/", + "research_bio": "INFORMATION FOR Our knowledge of the complex interplay between the various brain cell types is still rudimentary. Our laboratory is interested in understanding cell-cell interactions between neuronal and non-neuronal cells in health and disease, with a particular emphasis on cellular, molecular, and neural network mechanisms of neurodegeneration. Recent innovations in live imaging and optical probes are allowing sophisticated interrogation of the structural and functional cellular changes that occur in pathological processes. Our approach is to apply to and develop such methodologies to advance the understanding of the multicellular interactions in the native microenvironment and during homeostatic perturbations. This imaging-centric approach is combined with the use of viral vectors and in utero electroporation, optical sensors of cellular physiology, optogenetics, chemogenetics and genome editing techniques. We also have projects aimed at the development of potential therapies for neurodegenerative and microvascular pathologies. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Gunasekara Lab", + "lab_url": "https://medicine.yale.edu/lab/gunasekara/", + "research_bio": "INFORMATION FOR Copy Link Copy Link Thank you for your interest in our laboratory. We are always looking for motivated postdoctoral, predoctoral, undergraduate, and other trainees who are excited about basic and translational neuroscience, novel tool development, and drug discovery. If you are interested in learning more about our research opportunities, please feel free to email Roshan Gunasekara with a cover letter and resume. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/gunasekara/publications/", + "publications": null + }, + { + "lab_name": "Gunel Lab", + "lab_url": "https://medicine.yale.edu/lab/gunel/", + "research_bio": "INFORMATION FOR With the power of human genetics fueling our quest to better understand brain disorders, my lab utilizes state of the art genomics techniques and complex bioinformatic analysis for gene discovery followed by functional studies to pursue three major research interests: The overall goal of the lab is to understand the biology of these disorders and help design better/novel diagnostics, therapeutics and non-invasive treatments for these diseases. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/gunel/publications/", + "publications": [ + "Yale School of Medicine /", + "Neurosurgery /", + "Lab Members Alumni", + "Alumni", + "Contact", + "Research Developmental Neurogenetic Disorders Neurovascular Disorders Brain Tumors Translational Research", + "Developmental Neurogenetic Disorders", + "Neurovascular Disorders", + "Brain Tumors", + "Translational Research", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Lab Members", + "Research", + "Publications", + "News", + "Contact", + "", + "", + "", + "", + "", + "", + "", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "HABIT Lab", + "lab_url": "https://medicine.yale.edu/lab/bold/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/bold/publications/", + "publications": [ + "Yale School of Medicine /", + "Psychiatry /", + "Our Team", + "News", + "Research Projects", + "Lab Photos & Activities", + "Publications", + "Join Us", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Our Team", + "Research Projects", + "Publications", + "Join Us", + "News", + "Lab Photos & Activities", + "", + "", + "", + "", + "", + "", + "Menthol cigarette alternative products: Awareness, use, and substitution intentions among adults who smoke menthol cigarettes. Kyriakos CN, Kong G, Sharma A, Morean ME, Suttiratana SC, Bold KW. Addict Behav. 2025 Dec; 2025 Aug 27. PMID: 40876183.", + "Examining multiple substance use among Lesbian, Gay, and bisexual US adults. Mestre LM, Parker MA, Lee J, White MA, Bold KW. Addict Behav. 2025 Dec; 2025 Aug 24. PMID: 40876182.", + "Feasibility and efficacy of a real-time smoking intervention using wearable technology. Bold KW, Mestre LM, Garrison KA, Gueorguieva R, O'Malley SS, Fucito LM. PLOS Digit Health. 2025 Nov; 2025 Nov 10. PMID: 41212887.", + "Understanding Reasons to Quit or Reduce Vaping and Associations With Quitting Outcomes Among High School Adolescents in Connecticut. Bold KW, Kong G, Morean ME, Sharma A, Courtney W, Li W, Davis DR, Camenga D, Ouellette R, Krishnan-Sarin S. J Adolesc Health. 2025 Oct; 2025 Feb 20. PMID: 39985534.", + "Examining E-cigarette Flavor Use and Preference by Menthol Cigarette Status and Quit Duration Among U.S. Adults Using E-cigarettes in a Smoking Cessation Attempt. Joseph M, Morean ME, Wu R, Krishnan-Sarin S, O'Malley SS, Bold KW. Nicotine Tob Res. 2025 Aug 22. PMID: 40056399.", + "Putting the \"tobacco\" in tobacco-free blunt wraps: Early evidence from adolescents who use cannabis blunts signals a potential need for regulatory action. Morean ME, Ponte V, Li W, Davis DR, Sharma A, Krishnan-Sarin S, Bold KW, Kong G. Nicotine Tob Res. 2025 Jul 2; 2025 Jul 2. PMID: 40600673.", + "Understanding Use of E-cigarettes for Smoking Cessation Among a Sample of U.S. Adults. Sharma A, Morean ME, Krishnan-Sarin S, O'Malley SS, Bold KW. Nicotine Tob Res. 2025 Apr 22. PMID: 39475073.", + "Engaging Specific Populations With Tobacco-Related Health Disparities in Treatment Research: A Summary of a Society for Research on Nicotine and Tobacco Treatment Research Network Preconference Workshop. Johnson AL, Bui TC, Bullen C, Businelle M, Carroll DM, Correa-Fernández V, Pickner W, Spears CA, Vickerman K, Vidrine DJ, Webb Hooper M, Bold KW. Nicotine Tob Res. 2025 Apr 22. PMID: 39435861.", + "Perspectives on Clinical Pharmacist-Delivered Contingency Management to Promote Smoking Abstinence Among Individuals with HIV: A Qualitative Study. Bavishi P, Harsono D, Mistler C, Ledgerwood DM, Bold KW, Sigel K, Weiss J, Yager JE, Bernstein SL, Edelman EJ. AIDS Behav. 2025 Apr; 2025 Jan 7. PMID: 39776014.", + "Recommended self-report measures for use of menthol, mint and cooling-flavoured nicotine and tobacco products. Ozga JE, Bold KW, Giovenco DP, Villanti AC, Unger JB, Leventhal A, Stanton C. Tob Control. 2025 Feb 13; 2025 Feb 13. PMID: 39947699.", + "Use of cannabis among youth who vape nicotine. Davis DR, Bold KW, Wu R, Morean ME, Kong G, Krishnan-Sarin S. Addict Behav. 2025 Jan; 2024 Sep 22. PMID: 39326231.", + "Marketing strategies in business-to-business advertisements for oral nicotine products. Sharma A, Belton A, Ozga JE, Ling P, Hrywna M, Cornacchione Ross J, Ganz O, Bold KW, Stanton C. Tob Control. 2024 Nov 28; 2024 Nov 28. PMID: 39613332.", + "Urgent need for treatment addressing co-use of tobacco and cannabis: An updated review and considerations for future interventions. Nguyen N, Bold KW, McClure EA. Addict Behav. 2024 Nov; 2024 Jul 21. PMID: 39089194.", + "Higher prevalence of polysubstance use among older lesbian, and gay US adults. Mestre LM, White MA, Levy BR, Bold KW. Drug Alcohol Depend Rep. 2024 Sep; 2024 Sep 7. PMID: 39314854.", + "Psychometric evaluation of the Self-Report Habit Index for assessing habitual e-cigarette use behavior in high school adolescents. Morean ME, Davis DR, Kong G, Bold KW, Talley A, Krishnan-Sarin S. Drug Alcohol Depend Rep. 2024 Sep; 2024 Jun 28. PMID: 39050698.", + "E-cigarette dependence and cooling flavor use are linked among youth. Li W, Davis DR, Kong G, Bold KW, Morean ME, Camenga D, Sharma A, Lee J, Krishnan-Sarin S. Drug Alcohol Depend. 2024 Jul 1; 2024 May 11. PMID: 38744108.", + "Non-tobacco nicotine E-cigarette use and flavored E-cigarette use among young adults in the United States. Li W, Krishnan-Sarin S, Morean ME, Bold KW, Davis DR, Camenga DR, Kong G. Prev Med. 2024 Jul; 2024 May 11. PMID: 38735588.", + "The Scientific Basis for the Regulation of Flavors in Tobacco Products. Bold KW, Kong G, O'Malley SS. Annu Rev Clin Psychol. 2024 Jul; 2024 Jul 2. PMID: 38346292.", + "An Introduction and Practical Guide to Strategies for Analyzing Longitudinal Data in Clinical Trials of Smoking Cessation Treatment: Beyond Dichotomous Point-Prevalence Outcomes. Kypriotakis G, Bernstein SL, Bold KW, Dziura JD, Hedeker D, Mermelstein RJ, Weinberger AH. Nicotine Tob Res. 2024 Jun 21. PMID: 38214037.", + "Sources of exposure to non-tobacco nicotine electronic nicotine delivery systems and associations with susceptibility to use and use behaviors among young adults in the United States. Li W, Kong G, Davis DR, Bold KW, Krishnan-Sarin S, Camenga DR, Morean ME. PLoS One. 2024; 2024 May 8. PMID: 38718067.", + "Effect of a Personalized Tobacco Treatment Intervention on Smoking Abstinence in Individuals Eligible for Lung Cancer Screening. Cartmel B, Fucito LM, Bold KW, Neveu S, Li F, Rojewski AM, Gueorguieva R, O'Malley SS, Herbst RS, Toll BA. J Thorac Oncol. 2024 Apr; 2023 Nov 15. PMID: 37977486.", + "Tobacco-free blunt wraps: a regulatory conundrum. Kong G, Morean ME, Davis DR, Bold KW, Krishnan-Sarin S. Tob Control. 2024 Mar 19; 2024 Mar 19. PMID: 37604696.", + "A randomized controlled trial of potential tobacco policies prohibiting menthol flavor in cigarettes and e-cigarettes: a study protocol. Bold KW, Sharma A, Haeny A, Gueorguieva R, Buta E, Baldassarri S, Lempert L, Krishnan-Sarin S, O'Malley S. BMC Psychiatry. 2024 Mar 12; 2024 Mar 12. PMID: 38475757.", + "Why young adults use tobacco-free nicotine E-cigarettes: An analysis of qualitative data. Davis DR, Rajesh Kumar L, Morean ME, Kong G, Bold KW, Krishnan-Sarin S, Camenga DE. Addict Behav. 2024 Mar; 2023 Nov 24. PMID: 38056193.", + "Psychometric evaluation of the sensory e-cigarette expectancies scale for use with adolescents. Morean ME, Davis DR, Kong G, Bold KW, Krishnan-Sarin S. Addict Behav. 2024 Jan; 2023 Sep 23. PMID: 37778234.", + "Association of racial discrimination in health care settings and use of electronic cigarettes to quit smoking among Black adults. Jackson AB, Gibbons FX, Fleischli ME, Haeny AM, Bold KW, Suttiratana SC, Fagan P, Krishnan-Sarin S, Gerrard M. J Subst Use Addict Treat. 2023 Dec; 2023 Feb 22. PMID: 36822270.", + "\"Dysregulated not deficit\": A qualitative study on symptomatology of ADHD in young adults. Ginapp CM, Greenberg NR, MacDonald-Gagnon G, Angarita GA, Bold KW, Potenza MN. PLoS One. 2023; 2023 Oct 12. PMID: 37824501.", + "Accurately classifying cannabis blunt use as tobacco-cannabis co-use versus exclusive cannabis use. Morean ME, Kong G, Bold KW, Davis DR, Krishnan-Sarin S. Drug Alcohol Depend. 2023 Aug 1; 2023 May 21. PMID: 37270936.", + "Qualitative exploration of longer versus shorter quit attempts among adults using E-Cigarettes for combustible cigarette cessation. Suttiratana SC, Morean ME, Krishnan-Sarin S, Bold KW. Addict Behav. 2023 Aug; 2023 Mar 30. PMID: 37015170.", + "Smartphone Apps for Smoking Cessation: Systematic Framework for App Review and Analysis. Bold KW, Garrison KA, DeLucia A, Horvath M, Nguyen M, Camacho E, Torous J. J Med Internet Res. 2023 Jul 13; 2023 Jul 13. PMID: 37440305.", + "The experiences of adults with ADHD in interpersonal relationships and online communities: A qualitative study. Ginapp CM, Greenberg NR, Macdonald-Gagnon G, Angarita GA, Bold KW, Potenza MN. SSM Qual Res Health. 2023 Jun; 2023 Feb 1. PMID: 37539360.", + "The first nicotine product tried is associated with current multiple nicotine product use and nicotine dependence among a nationally representative sample of U.S. youths. Simon P, Buta E, Jackson A, Camenga DR, Kong G, Morean ME, Bold KW, Davis DR, Krishnan-Sarin S, Gueorguieva R. Prev Med. 2023 Apr; 2023 Jan 30. PMID: 36731754.", + "Use and Product Characteristics of \"Tobacco Free Nicotine\" E-Cigarettes Among Young Adults. Davis DR, Bold KW, Camenga D, Kong G, Jackson A, Lee J, Rajesh-Kumar L, Krishnan-Sarin S, Morean ME. Nicotine Tob Res. 2023 Feb 9. PMID: 35913677.", + "Awareness, susceptibility, and use of oral nicotine pouches and comparative risk perceptions with smokeless tobacco among young adults in the United States. Morean ME, Bold KW, Davis DR, Kong G, Krishnan-Sarin S, Camenga DR. PLoS One. 2023; 2023 Jan 30. PMID: 36716297.", + "\"Tobacco-free\" Nicotine Pouches: Risk Perceptions, Awareness, Susceptibility, and Use Among Young Adults in the United States. Morean ME, Bold KW, Davis DR, Kong G, Krishnan-Sarin S, Camenga DR. Nicotine Tob Res. 2023 Jan 1. PMID: 36000776.", + "Common Measures to Evaluate Flavored Tobacco Products: Recommendations From the Tobacco Centers for Regulatory Science (TCORS) Flavored Tobacco Products Measurement Subcommittee. Bansal-Travers M, Price SM, Bold KW, Villanti AC, Barnes A, Chansky M, Krishnan-Sarin S, Goniewicz ML. Nicotine Tob Res. 2023 Jan 1. PMID: 35896127.", + "Dual Use of Combustible Cigarettes and E-cigarettes: a Narrative Review of Current Evidence. Coleman SRM, Piper ME, Byron MJ, Bold KW. Curr Addict Rep. 2022 Dec; 2022 Oct 17. PMID: 36467719.", + "The Modified Cigarette Evaluation Questionnaire: Psychometric properties of the originally-proposed five-factor structure and a novel four-factor structure for use with adults who currently smoke cigarettes. Morean ME, Bold KW. Drug Alcohol Depend. 2022 Dec 1; 2022 Nov 4. PMID: 36371995.", + "Examining associations of e-cigarette flavour restrictions with e-cigarette use and success quitting smoking among US adults. Bold KW, Krishnan-Sarin S, O'Malley S, Morean ME. Tob Control. 2022 Nov. PMID: 36328465.", + "Curiosity, use, and perceptions of \"tobacco-free nicotine\" E-cigarettes among U.S. young adults. Camenga DR, Krishnan-Sarin S, Davis DR, Bold KW, Kong G, Morean ME. Prev Med. 2022 Nov; 2022 Oct 7. PMID: 36216122.", + "Association of youth impulsivity and use of e-cigarette devices, flavors, and frequency of use. Davis DR, Bold KW, Morean ME, Kong G, Jackson A, Simon P, Rajesh-Kumar L, Krishnan-Sarin S. Addict Behav. 2022 Nov; 2022 Jun 9. PMID: 35809413.", + "The lived experiences of adults with attention-deficit/hyperactivity disorder: A rapid review of qualitative evidence. Ginapp CM, Macdonald-Gagnon G, Angarita GA, Bold KW, Potenza MN. Front Psychiatry. 2022; 2022 Aug 11. PMID: 36032220.", + "The Modified E-Cigarette Evaluation Questionnaire: Psychometric Evaluation of an Adapted Version of the Modified Cigarette Evaluation Questionnaire for Use With Adults Who Use Electronic Nicotine Delivery Systems. Morean ME, Bold KW. Nicotine Tob Res. 2022 Aug 6. PMID: 35271732.", + "Practices, attitudes, and confidence related to tobacco treatment interventions in HIV clinics: a multisite cross-sectional survey. Bold KW, Deng Y, Dziura J, Porter E, Sigel KM, Yager JE, Ledgerwood DM, Bernstein SL, Edelman EJ. Transl Behav Med. 2022 Jul 7. PMID: 35608982.", + "Cigarette Smoking in Response to COVID-19: Examining Co-Morbid Medical Conditions and Risk Perceptions. Fucito LM, Bold KW, Cannon S, Serrantino A, Marrero R, O'Malley SS. Int J Environ Res Public Health. 2022 Jul 6; 2022 Jul 6. PMID: 35886090.", + "Examining the potential role of e-cigarettes to reduce health disparities associated with menthol cigarette use: Characterizing e-cigarette use, flavors, and reasons for use among US adults smoking menthol cigarettes. Bold KW, Buta E, Simon P, Gueorguieva R, Jackson A, Suttiratana SC, Krishnan-Sarin S, O'Malley SS. Drug Alcohol Depend. 2022 Jul 1; 2022 Apr 27. PMID: 35594642.", + "Does it come from tobacco? Young adults' interpretations of the term \"tobacco-free nicotine\" in a cross-sectional national survey sample. Morean ME, Bold KW, Davis DR, Kong G, Krishnan-Sarin S, Camenga DR. PLoS One. 2022; 2022 May 13. PMID: 35559988.", + "Examining Tobacco Treatment Perceptions and Barriers among Black versus Non-Black Adults Attending Lung Cancer Screening. Bold KW, Cannon S, Ford BB, Neveu S, Sather P, Toll BA, Fucito LM. Cancer Prev Res (Phila). 2022 May 3. PMID: 35063942.", + "Cannabis use among youth who vape nicotine E-cigarettes: A qualitative analysis. Davis DR, Bold KW, Kong G, Cavallo DA, Jackson A, Krishnan-Sarin S. Drug Alcohol Depend. 2022 May 1; 2022 Mar 19. PMID: 35339972.", + "Psychometric Evaluation of the Short-Form Vaping Consequences Questionnaire for Use With High School Adolescents Who Use and Do Not Use E-cigarettes. Morean ME, Davis DR, Bold KW, Kong G, Jackson A, Lee J, Rajesh Kumar L, Krishnan-Sarin S. Nicotine Tob Res. 2022 Mar 26. PMID: 34791432.", + "Demographic and substance use-related differences among high school adolescents who vape cannabis versus use other cannabis modalities. Morean ME, Davis DR, Kong G, Bold KW, Camenga DR, Suttiratana S, Lee J, Rajeshkumar L, Krishnan-Sarin S. Drug Alcohol Depend. 2021 Nov 1; 2021 Sep 27. PMID: 34607191.", + "Characteristics of Registered Clinical Trials Evaluating the Role of e-Cigarettes in Cessation or Reduction of Cigarette Smoking. Hung F, Wallach JD, O'Malley SS, Bold KW. JAMA Psychiatry. 2021 Nov 1. PMID: 34468716.", + "The effect of varenicline on smoking and drinking outcomes among Black and White adults with alcohol use disorder and co-occurring cigarette smoking: A secondary analysis of two clinical trials. Haeny AM, Gueorguieva R, Montgomery L, Bold KW, Fucito LM, Wu R, Muvvala SB, Zweben A, O'Malley SS. Addict Behav. 2021 Nov; 2021 May 1. PMID: 34216871.", + "A SMARTTT approach to Treating Tobacco use disorder in persons with HIV (SMARTTT): Rationale and design for a hybrid type 1 effectiveness-implementation study. Edelman EJ, Dziura J, Deng Y, Bold KW, Murphy SM, Porter E, Sigel KM, Yager JE, Ledgerwood DM, Bernstein SL. Contemp Clin Trials. 2021 Nov; 2021 Mar 29. PMID: 33794354.", + "Pilot Ecological Momentary Assessment Study of Subjective and Contextual Factors Surrounding E-Cigarette and Combustible Tobacco Product Use among Young Adults. Camenga DR, Haeny AM, Krishnan-Sarin S, O'Malley SS, Bold KW. Int J Environ Res Public Health. 2021 Oct 20; 2021 Oct 20. PMID: 34769525.", + "Cooling e-cigarette flavors and the association with e-cigarette use among a sample of high school students. Davis DR, Morean ME, Bold KW, Camenga D, Kong G, Jackson A, Simon P, Krishnan-Sarin S. PLoS One. 2021; 2021 Sep 1. PMID: 34469460.", + "Use and perceptions of electronic nicotine delivery systems among patients attending lung cancer screening who smoke. Fucito LM, Bold KW, Baldassarri SR, LaVigne JP, Ford B, Sather P, O'Malley SS, Toll BA. Prev Med Rep. 2021 Sep; 2021 Jun 9. PMID: 34235048.", + "Reward drinking and naltrexone treatment response among young adult heavy drinkers. Roos CR, Bold KW, Witkiewitz K, Leeman RF, DeMartini KS, Fucito LM, Corbin WR, Mann K, Kranzler HR, O'Malley SS. Addiction. 2021 Sep; 2021 Mar 18. PMID: 33620746.", + "Differences in JUUL Appeal Among Past and Current Youth JUUL Users. Davis DR, Krishnan-Sarin S, Bold KW, Morean ME, Jackson A, Camenga D, Kong G. Nicotine Tob Res. 2021 May 4. PMID: 33247938.", + "E-cigarette use perceptions that differentiate e-cigarette susceptibility and use among high school students. Burnley A, Bold KW, Kong G, Wu R, Krishnan-Sarin S. Am J Drug Alcohol Abuse. 2021 Mar 4; 2020 Oct 15. PMID: 33058696.", + "Informing the development of adolescent e-cigarette cessation interventions: A qualitative study. Kong G, Bold KW, Cavallo DA, Davis DR, Jackson A, Krishnan-Sarin S. Addict Behav. 2021 Mar; 2020 Oct 21. PMID: 33162230.", + "Adapting Research Protocols in Response to E-Cigarette, or Vaping, Product Use Associated Lung Injury: A Response to CDC Recommendations for E-Cigarette Trials. Davis DR, Fucito LM, Kong G, Jackson A, Bold KW, Baldassarri SR, Krishnan-Sarin S, O'Malley SS. Nicotine Tob Res. 2021 Feb 16. PMID: 31903483.", + "Trends in various e-cigarette devices used by high school adolescents from 2017-2019. Bold KW, Kong G, Morean M, Gueorguieva R, Camenga DR, Simon P, Davis DR, Jackson A, Krishnan-Sarin S. Drug Alcohol Depend. 2021 Feb 1; 2020 Dec 31. PMID: 33421797.", + "First tobacco product tried among adolescents based on race/ethnicity and socioeconomic status. Grobman B, Wu R, Jackson A, Bold KW, Morean ME, Camenga DR, Davis DR, Simon P, Krishnan-Sarin S, Kong G. Addict Behav. 2021 Feb; 2020 Sep 23. PMID: 33130462.", + "High school students' use of JUUL pod flavors before and after JUUL implemented voluntary sales restrictions on certain flavors in 2018. Morean ME, Bold KW, Kong G, Camenga DR, Jackson A, Simon P, Davis DR, Krishnan-Sarin S. PLoS One. 2020; 2020 Dec 15. PMID: 33320885.", + "E-cigarette devices used on school grounds. Jackson A, Kong G, Wu R, Morean ME, Davis DR, Camenga DR, Cavallo DA, Bold KW, Simon P, Krishnan-Sarin S. Addict Behav. 2020 Nov; 2020 Jun 21. PMID: 32622027.", + "Evaluating the effect of switching to non-menthol cigarettes among current menthol smokers: an empirical study of a potential ban of characterising menthol flavour in cigarettes. Bold KW, Jatlow P, Fucito LM, Eid T, Krishnan-Sarin S, O'Malley S. Tob Control. 2020 Nov; 2019 Nov 4. PMID: 31685586.", + "Using Latent Class Analysis to Examine Susceptibility to Various Tobacco Products Among Adolescents. Bold KW, Buta E, Simon P, Kong G, Morean M, Camenga D, Krishnan-Sarin S. Nicotine Tob Res. 2020 Oct 29. PMID: 31758190.", + "Dripping and vape tricks: Alternative e-cigarette use behaviors among adolescents. Kong G, Morean ME, Bold KW, Wu R, Bhatti H, Simon P, Krishnan-Sarin S. Addict Behav. 2020 Aug; 2020 Mar 21. PMID: 32222561.", + "Querying About the Use of Specific E-Cigarette Devices May Enhance Accurate Measurement of E-Cigarette Prevalence Rates Among High School Students. Morean ME, Camenga DR, Bold KW, Kong G, Jackson A, Simon P, Cavallo DA, Krishnan-Sarin S. Nicotine Tob Res. 2020 Apr 21. PMID: 30395344.", + "Association between preference for using alcohol beverage-named e-liquids and alcohol use among high school youth. Jackson A, Wu R, Kong G, Camenga DR, Morean M, Simon P, Bold KW, Haeny AM, Krishnan-Sarin S. Drug Alcohol Depend. 2020 Apr 1; 2020 Feb 10. PMID: 32078976.", + "Transitions across tobacco use profiles among adolescents: results from the Population Assessment of Tobacco and Health (PATH) study waves 1 and 2. Simon P, Buta E, Gueorguieva R, Kong G, Morean ME, Camenga DR, Bold KW, Krishnan-Sarin S. Addiction. 2020 Apr; 2020 Feb 5. PMID: 31618491.", + "High school students' use of flavored e-cigarette e-liquids for appetite control and weight loss. Morean ME, Bold KW, Kong G, Camenga DR, Simon P, Jackson A, Cavallo DA, Krishnan-Sarin S. Addict Behav. 2020 Mar; 2019 Oct 18. PMID: 31704428.", + "Smoking characteristics and alcohol use among women in treatment for alcohol use disorder. Bold KW, Rosen RL, Steinberg ML, Epstein EE, McCrady BS, Williams JM. Addict Behav. 2020 Feb; 2019 Oct 4. PMID: 31648138.", + "Appeal of JUUL among adolescents. Kong G, Bold KW, Morean ME, Bhatti H, Camenga DR, Jackson A, Krishnan-Sarin S. Drug Alcohol Depend. 2019 Dec 1; 2019 Oct 28. PMID: 31706249.", + "Adolescents' awareness of the nicotine strength and e-cigarette status of JUUL e-cigarettes. Morean ME, Bold KW, Kong G, Gueorguieva R, Camenga DR, Simon P, Jackson A, Cavallo DA, Krishnan-Sarin S. Drug Alcohol Depend. 2019 Nov 1; 2019 Aug 24. PMID: 31487572.", + "E-cigarettes: Tobacco policy and regulation. Bold KW, Krishnan-Sarin S. Curr Addict Rep. 2019 Jun; 2019 Apr 27. PMID: 31555499.", + "Longitudinal Findings from a Randomized Clinical Trial of Varenicline for Alcohol Use Disorder with Comorbid Cigarette Smoking. Bold KW, Zweben A, Fucito LM, Piepmeier ME, Muvvala S, Wu R, Gueorguieva R, O'Malley SS. Alcohol Clin Exp Res. 2019 May; 2019 Mar 21. PMID: 30817018.", + "A Pilot Clinical Trial of Smoking Cessation Services Implemented in the Workplace for Service Industry Employees. Bold KW, Kimmel L, Hanrahan TH, Romano D, Rojewski AM, Krishnan-Sarin S, Fucito LM, O'Malley SS. Am J Health Promot. 2019 May; 2018 Aug 28. PMID: 30153737.", + "E-cigarette devices used by high-school youth. Krishnan-Sarin S, Jackson A, Morean M, Kong G, Bold KW, Camenga DR, Cavallo DA, Simon P, Wu R. Drug Alcohol Depend. 2019 Jan 1; 2018 Nov 15. PMID: 30497057.", + "Daily relationship between positive affect and drinking to cope: the moderating role of difficulties regulating positive emotions. Weiss NH, Risi MM, Bold KW, Sullivan TP, Dixon-Gordon KL. Am J Drug Alcohol Abuse. 2019; 2018 Aug 23. PMID: 30136859.", + "Personalized Intervention Program: Tobacco Treatment for Patients at Risk for Lung Cancer. Bold KW, Toll BA, Cartmel B, Ford BB, Rojewski AM, Gueorguieva R, O'Malley SS, Fucito LM. J Smok Cessat. 2018 Dec; 2017 Dec 11. PMID: 32431757.", + "E-cigarette use as a potential cardiovascular disease risk behavior. Bold KW, Krishnan-Sarin S, Stoney CM. Am Psychol. 2018 Nov. PMID: 30394775.", + "Momentary assessment of impulsive choice and impulsive action: Reliability, stability, and correlates. McCarthy DE, Minami H, Bold KW, Yeh VM, Chapman G. Addict Behav. 2018 Aug; 2017 Nov 22. PMID: 29221928.", + "Socioeconomic status and adolescent e-cigarette use: The mediating role of e-cigarette advertisement exposure. Simon P, Camenga DR, Morean ME, Kong G, Bold KW, Cavallo DA, Krishnan-Sarin S. Prev Med. 2018 Jul; 2018 Apr 17. PMID: 29673887.", + "Trauma exposure and heavy drinking and drug use among college students: Identifying the roles of negative and positive affect lability in a daily diary study. Weiss NH, Bold KW, Contractor AA, Sullivan TP, Armeli S, Tennen H. Addict Behav. 2018 Apr; 2017 Dec 13. PMID: 29289852.", + "Measuring E-cigarette dependence: Initial guidance. Bold KW, Sussman S, O'Malley SS, Grana R, Foulds J, Fishbein H, Krishnan-Sarin S. Addict Behav. 2018 Apr; 2017 Nov 22. PMID: 29174664.", + "Effect of Varenicline Combined With Medical Management on Alcohol Use Disorder With Comorbid Cigarette Smoking: A Randomized Clinical Trial. O'Malley SS, Zweben A, Fucito LM, Wu R, Piepmeier ME, Ockert DM, Bold KW, Petrakis I, Muvvala S, Jatlow P, Gueorguieva R. JAMA Psychiatry. 2018 Feb 1. PMID: 29261824.", + "Ecological momentary analysis of the relations among stressful events, affective reactivity, and smoking among smokers with high versus low depressive symptoms during a quit attempt. Minami H, Frank BE, Bold KW, McCarthy DE. Addiction. 2018 Feb; 2017 Oct 12. PMID: 28779527.", + "Preferring more e-cigarette flavors is associated with e-cigarette use frequency among adolescents but not adults. Morean ME, Butler ER, Bold KW, Kong G, Camenga DR, Cavallo DA, Simon P, O'Malley SS, Krishnan-Sarin S. PLoS One. 2018; 2018 Jan 4. PMID: 29300749.", + "Trajectories of E-Cigarette and Conventional Cigarette Use Among Youth. Bold KW, Kong G, Camenga DR, Simon P, Cavallo DA, Morean ME, Krishnan-Sarin S. Pediatrics. 2018 Jan; 2017 Dec 4. PMID: 29203523.", + "Reciprocal variations in sleep and drinking over time among heavy-drinking young adults. Fucito LM, Bold KW, Van Reen E, Redeker NS, O'Malley SS, Hanrahan TH, DeMartini KS. J Abnorm Psychol. 2018 Jan; 2017 Nov 27. PMID: 29172601.", + "E-Cigarette Susceptibility as a Predictor of Youth Initiation of E-Cigarettes. Bold KW, Kong G, Cavallo DA, Camenga DR, Krishnan-Sarin S. Nicotine Tob Res. 2017 Dec 13. PMID: 28035000.", + "Early age of e-cigarette use onset mediates the association between impulsivity and e-cigarette use frequency in youth. Bold KW, Morean ME, Kong G, Simon P, Camenga DR, Cavallo DA, Krishnan-Sarin S. Drug Alcohol Depend. 2017 Dec 1; 2017 Oct 13. PMID: 29055268.", + "Adolescent and Young Adult Perceptions on Cigar Packaging: A Qualitative Study. Kong G, Cavallo DA, Bold KW, LaVallee H, Krishnan-Sarin S. Tob Regul Sci. 2017 Jul. PMID: 29082302.", + "Reasons for Cigarillo Initiation and Cigarillo Manipulation Methods among Adolescents. Kong G, Bold KW, Simon P, Camenga DR, Cavallo DA, Krishnan-Sarin S. Tob Regul Sci. 2017 Apr; 2017 Apr 1. PMID: 29085867.", + "Testing bidirectional associations among emotion regulation strategies and substance use: a daily diary study. Weiss NH, Bold KW, Sullivan TP, Armeli S, Tennen H. Addiction. 2017 Apr; 2017 Jan 2. PMID: 27896905.", + "E-Cigarettes and \"Dripping\" Among High-School Youth. Krishnan-Sarin S, Morean M, Kong G, Bold KW, Camenga DR, Cavallo DA, Simon P, Wu R. Pediatrics. 2017 Mar; 2017 Feb 6. PMID: 28167512.", + "Urgency traits moderate daily relations between affect and drinking to intoxication among young adults. Bold KW, Fucito LM, DeMartini KS, Leeman RF, Kranzler HR, Corbin WR, O'Malley SS. Drug Alcohol Depend. 2017 Jan 1; 2016 Nov 3. PMID: 27875802.", + "Baseline health status and quality of life after alcohol treatment for women with alcohol dependence. Bold KW, Epstein EE, McCrady BS. Addict Behav. 2017 Jan; 2016 Aug 10. PMID: 27543832.", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Halaban Lab", + "lab_url": "https://medicine.yale.edu/lab/halaban/", + "research_bio": "INFORMATION FOR The Halaban Lab’s primary areas of research interest are mutations and genomic aberrations associated with malignant transformation and pigmentation, targeted therapy, and immunobiology of melanoma.Ruth Halaban, PhDand her colleagues characterized the mutational landscape of more than 400 melanomas. They showed that NF1, a negative regulator of RAS, is the third most frequently mutated gene in melanoma, after BRAF and NRAS. They identified a recurrent UV- signature, activating P29S mutation in RAC1 in 5% of sun-exposed melanomas. Furthermore, in acral melanomas, they revealed late-arising focal amplifications in chr22q11.21, which include LZTR1 and CRKL, associated with poor outcomes and regional metastases. Most recently, they identified the immunological features associated with immune checkpoint inhibitors (ICI)-induced toxicity. They found that two pretreatment factors in circulation—activated CD4 memory T cell abundance and TCR diversity—are associated with severe irAE development regardless of organ system involvement. Dr. Halaban’s group discovered the growth factors requirements for normal human melanocytes and the role of bFGF in transformation to melanomas. They cloned the melanocytes specific genes tyrosinase (TYR) and PMEL (also known as SILV) and showed that mutations in TYR cause albinism. As the past Director of the Yale SPORE in Skin Cancer and current Co-Director of the Biospecimen Resource Core, Dr. Halaban established operating procedures for the collection of tumors, tissues, blood, normal skin, nevi, and clinical information, and routinely performs protein analyses, whole exome, and RNA sequencing of fresh tumors and matching PBLs. The samples and data are shared with investigators at Yale, both nationally and internationally. Antonella Bacchiocchi, MS Copy Link Research Associate Dermatology Copy Link", + "publications_page": "https://medicine.yale.edu/lab/halaban/publications", + "publications": null + }, + { + "lab_name": "Halene Lab", + "lab_url": "https://medicine.yale.edu/lab/halene/", + "research_bio": "INFORMATION FOR The Halene Laboratory focuses on the study of myeloid malignancies and hematopoiesis. In particular we seek to understand the role of mutations in splicing factors, present in nearly 50% of patient with Myelodysplasia (MDS) and Acute Myeloid Leukemia (AML).In addition, we seek to establish a “co-clinical” model for MDS and AML with the goal to facilitate the translation of improved, less toxic, and more efficient treatments for MDS and AML into the clinic. Copy Link Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Hang Zhou Lab", + "lab_url": "https://medicine.yale.edu/lab/hang-zhou/", + "research_bio": "INFORMATION FOR The Zhou Lab focuses on uncovering novel genetic risk factors and elucidating the genetic etiology of alcohol use disorder, substance use disorders, and their comorbidities using large-scale human genetic data. In recent years, the lab has led several impactful genome-wide association and whole-exome sequencing studies in this field (PMID: 38062264, 39145449, 39892688, 41052974). Supported by NIH grants, the lab is now expanding its research by leveraging the largest whole-genome sequencing datasets available from major biobanks. Current research areas include whole-genome and whole-exome sequencing, rare and structural variants, polygenic risk scores, functional prediction, causal variant fine-mapping, multi-omics integration, and data science approaches. We welcome postdoctoral researchers and students who are passionate about this field to join the Zhou Lab! Copy Link", + "publications_page": "https://medicine.yale.edu/lab/hang-zhou/publications/", + "publications": [ + "Yale School of Medicine /", + "Psychiatry /", + "People", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "People", + "Publications", + "News", + "", + "", + "", + "", + "", + "", + "Hang Zhou Lab 200 Edison Rd. Orange, CT 06477 Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Harpaz-Rotem PTSD Treatment & Research Lab", + "lab_url": "https://medicine.yale.edu/lab/harpazrotem/", + "research_bio": "INFORMATION FOR Copy Link Dr. Harpaz-Rotem’s main research interest aims to further improve the treatment of post-traumatic stress disorder (PTSD) by gaining understandings into the neurobiological, psychological and system issues that interface after exposure to trauma and its sequela. What differentiates resiliency from vulnerability? Who is more likely to develop PTSD and who might develop depression in the aftermath of trauma? Should we treat PTSD using psychological treatment, medications, or both? These important questions propel the research done in our lab and in collaboration with other investigators around the globe. If you are interested in participating in one of our studies please view the current ongoing studies on our website for further information. Copy Link The main purpose of this study is to examine behavioral and neural correlates of decision-making under risk and ambiguity conditions among veterans with PTSD. Behavioral and functional magnetic resonance imaging (fMRI) methods are used for detection. The experiments attempt to look at how people form and act upon the decisions they make. We also hope to figure out what brain processes might be involved in making these decisions. The fear learning study looks to understand how people with post-traumatic stress disorder (PTSD) learn about their environment. This study’s main purpose is to understand the neural mechanisms behind people learning feelings of safety, and of being threatened. This is a 7-day long medication and therapy study. We are looking at the potential use of Ketamine in enhancing the effectiveness of a week of Prolonged Exposure therapy. The purpose of this study is to provide those with psychiatric disorders with strategies that may improve self-control over neural functioning. Participants are taught tasks and techniques and an fMRI is used to look at the brain activation and patterns. What is unique about this study is the participant is able to see their body’s reaction in real time, as opposed to getting images later on. Copy Link For more information on the studies or to see if you are eligible to participate: Copy Link", + "publications_page": "https://medicine.yale.edu/lab/harpazrotem/publications/", + "publications": [ + "Yale School of Medicine /", + "Psychiatry /", + "Publications", + "News", + "Lab Members", + "Contact Us", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Publications", + "News", + "Lab Members", + "Contact Us", + "", + "", + "", + "", + "", + "", + "RESET post-traumatic stress disorder: clinical protocol integrating reconsolidation, exposure, short-term emotional transformation. Rubinstein D, Abargil M, Duek O, Harpaz-Rotem I. Eur J Psychotraumatol. 2025 Dec; 2025 Aug 15. PMID: 40815290.", + "Unraveling PTSD: Symptom cluster change during and 1 year after veterans' residential PTSD treatment. Gross GM, Spiller TR, Ben-Zion Z, Rubenstein A, Pietrzak RH, Duek O, Hoff R, Harpaz-Rotem I. Psychol Trauma. 2025 Nov; 2024 Jul 11. PMID: 38990694.", + "A preliminary evaluation of the effectiveness of massed delivery of PTSD psychotherapy in VA residential treatment. Holliday R, Holder N, Yamokoski C, Burden J, Sippel LM, Harpaz-Rotem I, Smith NB. Gen Hosp Psychiatry. 2025 Oct 10; 2025 Oct 10. PMID: 41086558.", + "Understanding PTSD and Dissociation in Wartime: Direct and Indirect Trauma Exposure. Rubinstein D, Lahad M, Aharonson-Daniel L, Proyer RT, Mizrahi D, Harpaz-Rotem I. J Trauma Dissociation. 2025 Oct 9; 2025 Oct 9. PMID: 41063635.", + "Trauma-related psychopathologies after extracorporeal membrane oxygenation support: A systematic review and meta-analysis. Demory A, Broden E, Equey L, Funaro MC, Sharifi M, Harpaz-Rotem I, Traube C, Karam O. Perfusion. 2025 Oct; 2025 Jan 29. PMID: 39879146.", + "Beta bursts mediate amygdala gating of hippocampal emotional encoding. Zhou Y, Huang Y, Pittaro G, Zareian B, Aljishi A, Toro AP, Zibly Z, Obaid S, Sivaraju A, Harpaz-Rotem I, Kaye A, Krystal J, Sheth K, Gu X, Pittenger C, Damisah EC. bioRxiv. 2025 Sep 27; 2025 Sep 27. PMID: 41040163.", + "Cannabinoid 1 receptor availability in posttraumatic stress disorder: A positron emission tomography study. Korem N, Bassir Nia A, Hillmer AT, D'Souza D, Nabulsi N, Ropchan J, Huang Y, Cosgrove K, Levy I, Pietrzak RH, Harpaz-Rotem I. Transl Psychiatry. 2025 Aug 22; 2025 Aug 22. PMID: 40846835.", + "A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study. See CRZ, Si S, Baird CL, Haswell CC, Hussain A, Olff M, Veltman DJ, Frijling JL, van Zuiden M, Koch SBJ, Nawijn L, Wang L, Zhu Y, Li G, Neria Y, Zhu X, Suarez-Jimenez B, Zilcha-Mano S, Lazarov A, Stevens JS, Ressler K, Fani N, Jovanovic T, van Rooij SJH, Kaufman ML, Lebois LAM, Rosso IM, Olson EA, Baker JT, Sponheim SR, Disner SG, Davenport ND, Etkin A, Maron-Katz A, Stein MB, Shenton ME, Stein DJ, Ipser J, Koopowitz SM, Seedat S, du Plessis S, van den Heuvel LL, Lissek S, Berg H, Straube T, Hofman D, Baugh LA, Forster GL, Simons RM, Simons JS, Magnotta VA, Fercho KA, Wang X, Cotton AS, O'Leary EN, Xie H, Grupe DW, Nitschke JB, Davidson RJ, Larson CL, deRoon-Cassini TA, Tomas CW, Fitzgerald JM, Blackford JU, Olatunji BO, Gordon EM, May G, Nelson SM, Lanius R, Théberge J, Densmore M, Neufeld RWJ, Abdallah CG, Averill CL, Harpaz-Rotem I, Levy I, Krystal JH, Geuze E, van Lutterveld R, Dennis EL, Tate DF, Cifu DX, Walker WC, Wilde EA, van der Wee NJA, Vermeiren RRJM, van der Werff SJA, McLaughlin K, Sambrook K, Peverill M, Radua J, Salminen LE, Jahanshad N, Thomopoulos SI, James A, Valmaggia L, Thompson PM, Morey RA, Kempton MJ. Eur Psychiatry. 2025 Jul 22; 2025 Jul 22. PMID: 40692500.", + "The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry. Chopra S, Cocuzza CV, Lawhead C, Ricard JA, Labache L, Patrick LM, Kumar P, Rubenstein A, Moses J, Chen L, Blankenbaker C, Gillis B, Germine LT, Harpaz-Rotem I, Yeo BTT, Baker JT, Holmes AJ. Sci Data. 2025 Jun 2; 2025 Jun 2. PMID: 40456751.", + "Cannabinoid Receptor Type 1 Availability in Individuals with a History of Childhood Trauma: A Positron Emission Tomography Study. Bassir Nia A, Aghaei AM, Pittman B, Korem N, D'Souza D, Potenza M, Hillmer A, Ranganathan M, Harpaz-Rotem I. Res Sq. 2025 May 30; 2025 May 30. PMID: 40502783.", + "Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors. Ben-Zion Z, Simon AJ, Rosenblatt M, Korem N, Duek O, Liberzon I, Shalev AY, Hendler T, Levy I, Harpaz-Rotem I, Scheinost D. JAMA Netw Open. 2025 Mar 3; 2025 Mar 3. PMID: 40063028.", + "Assessing and alleviating state anxiety in large language models. Ben-Zion Z, Witte K, Jagadish AK, Duek O, Harpaz-Rotem I, Khorsandian MC, Burrer A, Seifritz E, Homan P, Schulz E, Spiller TR. NPJ Digit Med. 2025 Mar 3; 2025 Mar 3. PMID: 40033130.", + "Suicide Risk Among Veterans Who Receive Evidence-Based Therapy for Posttraumatic Stress Disorder. Saulnier KG, Brabbs S, Szymanski BR, Harpaz-Rotem I, McCarthy JF, Sripada RK. JAMA Netw Open. 2024 Dec 2; 2024 Dec 2. PMID: 39724372.", + "Cerebellar Contributions to Traumatic Autobiographical Memory in People with Post-Traumatic Stress Disorder. Blithikioti C, Duek O, Gordon C, Krystal JH, Levy I, Harpaz-Rotem I, Schiller D, Perl O. Cerebellum. 2024 Dec; 2024 Aug 24. PMID: 39180693.", + "Generalizable and replicable brain-based predictions of cognitive functioning across common psychiatric illness. Chopra S, Dhamala E, Lawhead C, Ricard JA, Orchard ER, An L, Chen P, Wulan N, Kumar P, Rubenstein A, Moses J, Chen L, Levi P, Holmes A, Aquino K, Fornito A, Harpaz-Rotem I, Germine LT, Baker JT, Yeo BTT, Holmes AJ. Sci Adv. 2024 Nov 8; 2024 Nov 6. PMID: 39504381.", + "Unveiling the Structure in Mental Disorder Presentations. Spiller TR, Duek O, Helmer M, Murray JD, Fielstein E, Pietrzak RH, von Känel R, Harpaz-Rotem I. JAMA Psychiatry. 2024 Nov 1. PMID: 39110437.", + "Prevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans. Fischer IC, Na PJ, Harpaz-Rotem I, Marx BP, Pietrzak RH. J Clin Psychiatry. 2024 Oct 23; 2024 Oct 23. PMID: 39480145.", + "Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. Korem N, Hillmer AT, D'Souza DC, Bassir Nia A, Levy I, Pietrzak RH, Harpaz-Rotem I. JAMA Netw Open. 2024 Sep 3; 2024 Sep 3. PMID: 39250156.", + "Post-treatment alterations in white matter integrity in PTSD: Effects on symptoms and functional connectivity a secondary analysis of an RCT. Korem N, Duek O, Ben-Zion Z, Spiller TR, Gordon C, Amen S, Levy I, Harpaz-Rotem I. Psychiatry Res Neuroimaging. 2024 Sep; 2024 Aug 2. PMID: 39111111.", + "Barriers to Mental Health Care in US Military Veterans. Lewis C, Fischer IC, Tsai J, Harpaz-Rotem I, Pietrzak RH. Psychiatr Q. 2024 Sep; 2024 Jun 28. PMID: 38940875.", + "Some closure on exposure-Realigning the perspective on trauma treatment and finding a pathway forward: Reply to Brown (2024) and Najavits (2024). Rubenstein A, Doran J, Duek O, Harpaz-Rotem I. Am Psychol. 2024 Apr. PMID: 38635198.", + "To expose or not to expose: A comprehensive perspective on treatment for posttraumatic stress disorder. Rubenstein A, Duek O, Doran J, Harpaz-Rotem I. Am Psychol. 2024 Apr. PMID: 38635195.", + "Emotional State Transitions in Trauma-Exposed Individuals With and Without Posttraumatic Stress Disorder. Korem N, Duek O, Spiller T, Ben-Zion Z, Levy I, Harpaz-Rotem I. JAMA Netw Open. 2024 Apr 1; 2024 Apr 1. PMID: 38625701.", + "What Happens Next? Maintenance of Gains After Discharge From VA Residential PTSD Treatment. Grau PP, Harpaz-Rotem I, Ilgen MA, Ganoczy D, Sripada RK. J Nerv Ment Dis. 2024 Apr 1; 2024 Jan 6. PMID: 38536046.", + "Functional correlates of a novel 8-factor model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Stiltner B, Fischer IC, Duek O, Polimanti R, Harpaz-Rotem I, Pietrzak RH. J Psychiatr Res. 2024 Mar; 2024 Jan 11. PMID: 38244335.", + "Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup. Huggins AA, Baird CL, Briggs M, Laskowitz S, Hussain A, Fouda S, Haswell C, Sun D, Salminen LE, Jahanshad N, Thomopoulos SI, Veltman DJ, Frijling JL, Olff M, van Zuiden M, Koch SBJ, Nawjin L, Wang L, Zhu Y, Li G, Stein DJ, Ipser J, Seedat S, du Plessis S, van den Heuvel LL, Suarez-Jimenez B, Zhu X, Kim Y, He X, Zilcha-Mano S, Lazarov A, Neria Y, Stevens JS, Ressler KJ, Jovanovic T, van Rooij SJH, Fani N, Hudson AR, Mueller SC, Sierk A, Manthey A, Walter H, Daniels JK, Schmahl C, Herzog JI, Říha P, Rektor I, Lebois LAM, Kaufman ML, Olson EA, Baker JT, Rosso IM, King AP, Liberzon I, Angstadt M, Davenport ND, Sponheim SR, Disner SG, Straube T, Hofmann D, Qi R, Lu GM, Baugh LA, Forster GL, Simons RM, Simons JS, Magnotta VA, Fercho KA, Maron-Katz A, Etkin A, Cotton AS, O'Leary EN, Xie H, Wang X, Quidé Y, El-Hage W, Lissek S, Berg H, Bruce S, Cisler J, Ross M, Herringa RJ, Grupe DW, Nitschke JB, Davidson RJ, Larson CL, deRoon-Cassini TA, Tomas CW, Fitzgerald JM, Blackford JU, Olatunji BO, Kremen WS, Lyons MJ, Franz CE, Gordon EM, May G, Nelson SM, Abdallah CG, Levy I, Harpaz-Rotem I, Krystal JH, Dennis EL, Tate DF, Cifu DX, Walker WC, Wilde EA, Harding IH, Kerestes R, Thompson PM, Morey R. Mol Psychiatry. 2024 Mar; 2024 Jan 10. PMID: 38195980.", + "Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods. Yang J, Huggins AA, Sun D, Baird CL, Haswell CC, Frijling JL, Olff M, van Zuiden M, Koch SBJ, Nawijn L, Veltman DJ, Suarez-Jimenez B, Zhu X, Neria Y, Hudson AR, Mueller SC, Baker JT, Lebois LAM, Kaufman ML, Qi R, Lu GM, Říha P, Rektor I, Dennis EL, Ching CRK, Thomopoulos SI, Salminen LE, Jahanshad N, Thompson PM, Stein DJ, Koopowitz SM, Ipser JC, Seedat S, du Plessis S, van den Heuvel LL, Wang L, Zhu Y, Li G, Sierk A, Manthey A, Walter H, Daniels JK, Schmahl C, Herzog JI, Liberzon I, King A, Angstadt M, Davenport ND, Sponheim SR, Disner SG, Straube T, Hofmann D, Grupe DW, Nitschke JB, Davidson RJ, Larson CL, deRoon-Cassini TA, Blackford JU, Olatunji BO, Gordon EM, May G, Nelson SM, Abdallah CG, Levy I, Harpaz-Rotem I, Krystal JH, Morey RA, Sotiras A. Neuropsychopharmacology. 2024 Feb; 2023 Nov 28. PMID: 38017161.", + "Evaluating a novel 8-factor dimensional model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Stiltner B, Fischer IC, Duek O, Polimanti R, Harpaz-Rotem I, Pietrzak RH. J Affect Disord. 2024 Feb 1; 2023 Nov 17. PMID: 37979626.", + "Effects of a dissociative drug on fronto-limbic resting-state functional connectivity in individuals with posttraumatic stress disorder: a randomized controlled pilot study. Danböck SK, Duek O, Ben-Zion Z, Korem N, Amen SL, Kelmendi B, Wilhelm FH, Levy I, Harpaz-Rotem I. Psychopharmacology (Berl). 2024 Feb; 2023 Oct 23. PMID: 37872291.", + "Structural Neuroimaging of Hippocampus and Amygdala Subregions in Posttraumatic Stress Disorder: A Scoping Review. Ben-Zion Z, Korem N, Fine NB, Katz S, Siddhanta M, Funaro MC, Duek O, Spiller TR, Danböck SK, Levy I, Harpaz-Rotem I. Biol Psychiatry Glob Open Sci. 2024 Jan; 2023 Jul 13. PMID: 38298789.", + "Neural patterns differentiate traumatic from sad autobiographical memories in PTSD. Perl O, Duek O, Kulkarni KR, Gordon C, Krystal JH, Levy I, Harpaz-Rotem I, Schiller D. Nat Neurosci. 2023 Dec; 2023 Nov 30. PMID: 38036701.", + "Firearm Ownership Among a Nationally Representative Sample of U.S. Veterans. Fischer IC, Aunon FM, Nichter B, Hill ML, Panza KE, Kline AC, Na PJ, Tsai J, Harpaz-Rotem I, Pietrzak RH. Am J Prev Med. 2023 Dec; 2023 Jun 23. PMID: 37354925.", + "Not all traumas are created equal: Phenotypic heterogeneity of PTSD symptoms in relation to index traumas in U.S. military veterans. Kachadourian LK, Duek O, Tsai J, Harpaz-Rotem I, Pietrzak RH. J Affect Disord. 2023 Nov 1; 2023 Aug 11. PMID: 37572698.", + "Purpose in life protects against the development of suicidal thoughts and behaviors in U.S. veterans without a history of suicidality: A 10-year, nationally representative, longitudinal study. Fischer IC, Nichter B, Feldman DB, Na PJ, Tsai J, Harpaz-Rotem I, Schulenberg SE, Pietrzak RH. J Affect Disord. 2023 Nov 1; 2023 Aug 7. PMID: 37557988.", + "Clinical outcomes of veterans affairs residential PTSD treatment for PTSD and depressive symptoms: 1-year follow-up outcomes and gender differences. Gross GM, Spiller TR, Carretta R, Sippel LM, Smith N, Harpaz-Rotem I. Psychol Trauma. 2023 Nov; 2023 May 18. PMID: 37199985.", + "Correlates of avoidance coping in trauma-exposed U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Korem N, Ben-Zion Z, Spiller TR, Duek OA, Harpaz-Rotem I, Pietrzak RH. J Affect Disord. 2023 Oct 15; 2023 Jul 11. PMID: 37437721.", + "Underlying Hippocampal Mechanism of Posttraumatic Stress Disorder Treatment Outcome: Evidence From Two Clinical Trials. Zilcha-Mano S, Duek O, Suarez-Jimenez B, Zhu X, Lazarov A, Helpman L, Korem N, Malka M, Harpaz-Rotem I, Neria Y. Biol Psychiatry Glob Open Sci. 2023 Oct; 2023 Feb 3. PMID: 37881552.", + "Post-traumatic stress disorder: rethinking diagnosis. Fischer IC, Pietrzak RH, Maercker A, Shalev AY, Katz IR, Harpaz-Rotem I. Lancet Psychiatry. 2023 Oct; 2023 Jul 24. PMID: 37499676.", + "Long term structural and functional neural changes following a single infusion of Ketamine in PTSD. Duek O, Korem N, Li Y, Kelmendi B, Amen S, Gordon C, Milne M, Krystal JH, Levy I, Harpaz-Rotem I. Neuropsychopharmacology. 2023 Oct; 2023 Jun 3. PMID: 37270621.", + "Comparative effectiveness of evidence-based psychotherapies for PTSD delivered in VA residential PTSD treatment. Sippel LM, Gross GM, Spiller TR, Duek O, Smith N, Hoff R, Harpaz-Rotem I. Psychol Med. 2023 Oct; 2023 Mar 27. PMID: 36971021.", + "Identifying significant correlates of purpose in life in older US military veterans: results from the national health and resilience in veterans study. Fischer IC, Feldman DB, Tsai J, Harpaz-Rotem I, Lucas KA, Schulenberg SE, Pietrzak RH. Int Psychogeriatr. 2023 Oct; 2023 Jan 30. PMID: 36715004.", + "Changes in mental health among U.S. military veterans during the COVID-19 pandemic: A network analysis. Spiller TR, Na PJ, Merians AN, Duek O, Ben-Zion Z, Tsai J, von Känel R, Harpaz-Rotem I, Pietrzak RH. J Psychiatr Res. 2023 Sep; 2023 Aug 11. PMID: 37595331.", + "Comparative effectiveness of group v. individual trauma-focused treatment for posttraumatic stress disorder in veterans. Spiller TR, Duek O, Buta E, Gross G, Smith NB, Harpaz-Rotem I. Psychol Med. 2023 Jul; 2022 Aug 12. PMID: 35959560.", + "Amygdala downregulation training using fMRI neurofeedback in post-traumatic stress disorder: a randomized, double-blind trial. Zhao Z, Duek O, Seidemann R, Gordon C, Walsh C, Romaker E, Koller WN, Horvath M, Awasthi J, Wang Y, O'Brien E, Fichtenholtz H, Hampson M, Harpaz-Rotem I. Transl Psychiatry. 2023 May 25; 2023 May 25. PMID: 37230984.", + "Purpose in life and physical health in older U.S. military veterans: Cross-sectional results from the National Health and Resilience in Veterans Study. Fischer IC, Feldman DB, Tsai J, Harpaz-Rotem I, McCutcheon VE, Schulenberg SE, Pietrzak RH. Prev Med. 2023 May; 2023 Mar 29. PMID: 37001606.", + "Racial and ethnic mental health disparities in U.S. Military Veterans: Results from the National Health and Resilience in Veterans Study. Merians AN, Gross G, Spoont MR, Bellamy CD, Harpaz-Rotem I, Pietrzak RH. J Psychiatr Res. 2023 May; 2023 Mar 4. PMID: 36905842.", + "Clinical significance of novel 8-factor model of DSM-5 PTSD in national VA PTSD residential treatment data: Internally- v. externally-cued intrusions. Gross GM, Spiller TR, Duek O, Pietrzak RH, Harpaz-Rotem I. J Affect Disord. 2023 May 1; 2023 Feb 16. PMID: 36806596.", + "Understanding veteran barriers to specialty outpatient PTSD clinical care. Rozek DC, Steigerwald VL, Baker SN, Gross G, Maieritsch KP, Hoff R, Harpaz-Rotem I, Smith NB. J Anxiety Disord. 2023 Apr; 2023 Feb 14. PMID: 36854224.", + "Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach. Jia R, Ruderman L, Pietrzak RH, Gordon C, Ehrlich D, Horvath M, Mirchandani S, DeFontes C, Southwick S, Krystal JH, Harpaz-Rotem I, Levy I. Transl Psychiatry. 2023 Mar 28; 2023 Mar 28. PMID: 36977676.", + "Distinguishing emotional numbing symptoms of posttraumatic stress disorder from major depressive disorder. Duek O, Seidemann R, Pietrzak RH, Harpaz-Rotem I. J Affect Disord. 2023 Mar 1; 2022 Dec 29. PMID: 36586605.", + "Characterization of Mental Health in US Veterans Before, During, and 2 Years After the Onset of the COVID-19 Pandemic. Fischer IC, Na PJ, Harpaz-Rotem I, Krystal JH, Pietrzak RH. JAMA Netw Open. 2023 Feb 1; 2023 Feb 1. PMID: 36821116.", + "Evaluating the Evidence for Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma. Ben-Zion Z, Spiller TR, Keynan JN, Admon R, Levy I, Liberzon I, Shalev AY, Hendler T, Harpaz-Rotem I. Am J Psychiatry. 2023 Feb 1; 2023 Jan 11. PMID: 36628514.", + "Longitudinal volumetric evaluation of hippocampus and amygdala subregions in recent trauma survivors. Ben-Zion Z, Korem N, Spiller TR, Duek O, Keynan JN, Admon R, Harpaz-Rotem I, Liberzon I, Shalev AY, Hendler T. Mol Psychiatry. 2023 Feb; 2022 Oct 24. PMID: 36280750.", + "Perceived Purpose in Life, Mental Health, and Suicidality in Older U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study. Fischer IC, Tsai J, Harpaz-Rotem I, McCutcheon VE, Schulenberg SE, Pietrzak RH. Am J Geriatr Psychiatry. 2023 Feb; 2022 Sep 24. PMID: 36253289.", + "Post-traumatic Stress Disorder. Merians AN, Spiller T, Harpaz-Rotem I, Krystal JH, Pietrzak RH. Med Clin North Am. 2023 Jan; 2022 Oct 28. PMID: 36402502.", + "Mapping the availability of translated versions of posttraumatic stress disorder screening questionnaires for adults: A scoping review. Hoffman J, Ben-Zion Z, Arévalo A, Duek O, Greene T, Hall BJ, Harpaz-Rotem I, Liddell B, Locher C, Morina N, Nickerson A, Pfaltz MC, Schick M, Schnyder U, Seedat S, Shatri F, Sit HF, von Känel R, Spiller TR. Eur J Psychotraumatol. 2022 Dec; 2022 Nov 25. PMID: 38872602.", + "Treatment response trajectories in residential PTSD programs for veterans: A national cohort investigation. Grau PP, Sripada RK, Pietrzak RH, Ganoczy D, Harpaz-Rotem I. J Anxiety Disord. 2022 Dec; 2022 Oct 31. PMID: 36334317.", + "Delirium screening in an acute care setting with a machine learning classifier based on routinely collected nursing data: A model development study. Spiller TR, Tufan E, Petry H, Böttger S, Fuchs S, Duek O, Ben-Zion Z, Korem N, Harpaz-Rotem I, von Känel R, Ernst J. J Psychiatr Res. 2022 Dec; 2022 Oct 10. PMID: 36252349.", + "A comparison of methods to harmonize cortical thickness measurements across scanners and sites. Sun D, Rakesh G, Haswell CC, Logue M, Baird CL, O'Leary EN, Cotton AS, Xie H, Tamburrino M, Chen T, Dennis EL, Jahanshad N, Salminen LE, Thomopoulos SI, Rashid F, Ching CRK, Koch SBJ, Frijling JL, Nawijn L, van Zuiden M, Zhu X, Suarez-Jimenez B, Sierk A, Walter H, Manthey A, Stevens JS, Fani N, van Rooij SJH, Stein M, Bomyea J, Koerte IK, Choi K, van der Werff SJA, Vermeiren RRJM, Herzog J, Lebois LAM, Baker JT, Olson EA, Straube T, Korgaonkar MS, Andrew E, Zhu Y, Li G, Ipser J, Hudson AR, Peverill M, Sambrook K, Gordon E, Baugh L, Forster G, Simons RM, Simons JS, Magnotta V, Maron-Katz A, du Plessis S, Disner SG, Davenport N, Grupe DW, Nitschke JB, deRoon-Cassini TA, Fitzgerald JM, Krystal JH, Levy I, Olff M, Veltman DJ, Wang L, Neria Y, De Bellis MD, Jovanovic T, Daniels JK, Shenton M, van de Wee NJA, Schmahl C, Kaufman ML, Rosso IM, Sponheim SR, Hofmann DB, Bryant RA, Fercho KA, Stein DJ, Mueller SC, Hosseini B, Phan KL, McLaughlin KA, Davidson RJ, Larson CL, May G, Nelson SM, Abdallah CG, Gomaa H, Etkin A, Seedat S, Harpaz-Rotem I, Liberzon I, van Erp TGM, Quidé Y, Wang X, Thompson PM, Morey RA. Neuroimage. 2022 Nov 1; 2022 Jul 30. PMID: 35917919.", + "Emotional numbing in PTSD is associated with lower amygdala reactivity to pain. Korem N, Duek O, Ben-Zion Z, Kaczkurkin AN, Lissek S, Orederu T, Schiller D, Harpaz-Rotem I, Levy I. Neuropsychopharmacology. 2022 Oct; 2022 Aug 9. PMID: 35945274.", + "Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium. Sun D, Rakesh G, Clarke-Rubright EK, Haswell CC, Logue MW, O'Leary EN, Cotton AS, Xie H, Dennis EL, Jahanshad N, Salminen LE, Thomopoulos SI, Rashid FM, Ching CRK, Koch SBJ, Frijling JL, Nawijn L, van Zuiden M, Zhu X, Suarez-Jimenez B, Sierk A, Walter H, Manthey A, Stevens JS, Fani N, van Rooij SJH, Stein MB, Bomyea J, Koerte I, Choi K, van der Werff SJA, Vermeiren RRJM, Herzog JI, Lebois LAM, Baker JT, Ressler KJ, Olson EA, Straube T, Korgaonkar MS, Andrew E, Zhu Y, Li G, Ipser J, Hudson AR, Peverill M, Sambrook K, Gordon E, Baugh LA, Forster G, Simons RM, Simons JS, Magnotta VA, Maron-Katz A, du Plessis S, Disner SG, Davenport ND, Grupe D, Nitschke JB, deRoon-Cassini TA, Fitzgerald J, Krystal JH, Levy I, Olff M, Veltman DJ, Wang L, Neria Y, De Bellis MD, Jovanovic T, Daniels JK, Shenton ME, van de Wee NJA, Schmahl C, Kaufman ML, Rosso IM, Sponheim SR, Hofmann DB, Bryant RA, Fercho KA, Stein DJ, Mueller SC, Phan KL, McLaughlin KA, Davidson RJ, Larson C, May G, Nelson SM, Abdallah CG, Gomaa H, Etkin A, Seedat S, Harpaz-Rotem I, Liberzon I, Wang X, Thompson PM, Morey RA. Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Sep; 2022 Mar 15. PMID: 35307575.", + "Risk for PTSD symptom worsening during new PTSD treatment episode in a nationally representative sample of treatment-seeking U.S. veterans with subthreshold PTSD. Gross GM, Pietrzak RH, Hoff RA, Katz IR, Harpaz-Rotem I. J Psychiatr Res. 2022 Jul; 2022 May 2. PMID: 35526446.", + "Mental Health Care Use Among U.S. Military Veterans: Results From the 2019-2020 National Health and Resilience in Veterans Study. Kline AC, Panza KE, Nichter B, Tsai J, Harpaz-Rotem I, Norman SB, Pietrzak RH. Psychiatr Serv. 2022 Jun; 2021 Nov 15. PMID: 34775790.", + "Exploration of a Novel Model of Intrusive Symptoms in Posttraumatic Stress Disorder Among US Veterans. Duek O, Spiller TR, Rubenstein A, Pietrzak RH, Harpaz-Rotem I. JAMA Netw Open. 2022 Mar 1; 2022 Mar 1. PMID: 35311966.", + "Racial Disparities in Clinical Outcomes of Veterans Affairs Residential PTSD Treatment Between Black and White Veterans. Gross GM, Smith N, Holliday R, Rozek DC, Hoff R, Harpaz-Rotem I. Psychiatr Serv. 2022 Feb 1; 2021 Aug 9. PMID: 34369806.", + "Mental Health Burden in Enlisted and Commissioned U.S. Military Veterans: Importance of Indirect Trauma Exposure in Commissioned Veterans. Merians AN, Na PJ, Tsai J, Harpaz-Rotem I, Pietrzak RH. Psychiatry. 2022 Winter; 2022 May 9. PMID: 35532217.", + "Thank You for Hearing My Voice - Listening to Women Combat Veterans in the United States and Israeli Militaries. Daphna-Tekoah S, Harel-Shalev A, Harpaz-Rotem I. Front Psychol. 2021; 2021 Dec 6. PMID: 34938240.", + "Religion, spirituality, and risk for incident posttraumatic stress disorder, suicidal ideation, and hazardous drinking in U.S. military veterans: A 7-year, nationally representative, prospective cohort study. Rubenstein A, Koenig HG, Marin DB, Sharma V, Harpaz-Rotem I, Pietrzak RH. J Affect Disord. 2021 Dec 1; 2021 Sep 2. PMID: 34706422.", + "Binge drinking following residential treatment for posttraumatic stress disorder among veterans with and without alcohol use disorder. Meshberg-Cohen S, Gross GM, Kachadourian LK, Harpaz-Rotem I. J Psychiatr Res. 2021 Nov; 2021 Sep 3. PMID: 34500350.", + "In Their Own Words: Veteran Experiences with Evidence-Based Treatments for PTSD in the Veterans Health Administration. Doran JM, O'Shea M, Harpaz-Rotem I. Psychiatr Q. 2021 Sep; 2021 Jan 6. PMID: 33409926.", + "The hidden burden of social anxiety disorder in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Byrne SP, Fogle BM, Asch R, Esterlis I, Harpaz-Rotem I, Tsai J, Pietrzak RH. J Affect Disord. 2021 Aug 1; 2021 May 3. PMID: 34022553.", + "Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis. Wang X, Xie H, Chen T, Cotton AS, Salminen LE, Logue MW, Clarke-Rubright EK, Wall J, Dennis EL, O'Leary BM, Abdallah CG, Andrew E, Baugh LA, Bomyea J, Bruce SE, Bryant R, Choi K, Daniels JK, Davenport ND, Davidson RJ, DeBellis M, deRoon-Cassini T, Disner SG, Fani N, Fercho KA, Fitzgerald J, Forster GL, Frijling JL, Geuze E, Gomaa H, Gordon EM, Grupe D, Harpaz-Rotem I, Haswell CC, Herzog JI, Hofmann D, Hollifield M, Hosseini B, Hudson AR, Ipser J, Jahanshad N, Jovanovic T, Kaufman ML, King AP, Koch SBJ, Koerte IK, Korgaonkar MS, Krystal JH, Larson C, Lebois LAM, Levy I, Li G, Magnotta VA, Manthey A, May G, McLaughlin KA, Mueller SC, Nawijn L, Nelson SM, Neria Y, Nitschke JB, Olff M, Olson EA, Peverill M, Phan KL, Rashid FM, Ressler K, Rosso IM, Sambrook K, Schmahl C, Shenton ME, Sierk A, Simons JS, Simons RM, Sponheim SR, Stein MB, Stein DJ, Stevens JS, Straube T, Suarez-Jimenez B, Tamburrino M, Thomopoulos SI, van der Wee NJA, van der Werff SJA, van Erp TGM, van Rooij SJH, van Zuiden M, Varkevisser T, Veltman DJ, Vermeiren RRJM, Walter H, Wang L, Zhu Y, Zhu X, Thompson PM, Morey RA, Liberzon I. Mol Psychiatry. 2021 Aug; 2020 Dec 7. PMID: 33288872.", + "Network analysis of PTSD and depressive symptoms in 158,139 treatment-seeking veterans with PTSD. Duek O, Spiller TR, Pietrzak RH, Fried EI, Harpaz-Rotem I. Depress Anxiety. 2021 May; 2020 Nov 15. PMID: 33190348.", + "Cannabinoid Receptor 1 rs1049353 Variant, Childhood Abuse, and the Heterogeneity of PTSD Symptoms: Results From the National Health and Resilience in Veterans Study. Korem N, Duek O, Xu K, Harpaz-Rotem I, Pietrzak RH. Chronic Stress (Thousand Oaks). 2021 Jan-Dec; 2021 Apr 29. PMID: 33997583.", + "The Reward System and Post-Traumatic Stress Disorder: Does Trauma Affect the Way We Interact With Positive Stimuli? Seidemann R, Duek O, Jia R, Levy I, Harpaz-Rotem I. Chronic Stress (Thousand Oaks). 2021 Jan-Dec; 2021 Feb 25. PMID: 33718742.", + "Longitudinal courses of suicidal ideation in U.S. military veterans: a 7-year population-based, prospective cohort study. Herzog S, Tsai J, Nichter B, Kachadourian L, Harpaz-Rotem I, Pietrzak RH. Psychol Med. 2021 Feb 19; 2021 Feb 19. PMID: 33602367.", + "Mindfulness as a mediator between trauma exposure and mental health outcomes: Results from the National Health and Resilience in Veterans Study. Kachadourian LK, Harpaz-Rotem I, Tsai J, Southwick S, Pietrzak RH. Psychol Trauma. 2021 Feb; 2021 Jan 21. PMID: 33475404.", + "Early discontinuation of pharmacotherapy in U.S. veterans diagnosed with PTSD and the role of psychotherapy. Duek O, Pietrzak RH, Petrakis I, Hoff R, Harpaz-Rotem I. J Psychiatr Res. 2021 Jan; 2020 Oct 17. PMID: 33126010.", + "The National Health and Resilience in Veterans Study: A Narrative Review and Future Directions. Fogle BM, Tsai J, Mota N, Harpaz-Rotem I, Krystal JH, Southwick SM, Pietrzak RH. Front Psychiatry. 2020; 2020 Dec 9. PMID: 33362593.", + "Dissociative symptoms predict risk for the development of PTSD: Results from the National Health and Resilience in Veterans Study (NHRVS). Herzog S, Fogle BM, Harpaz-Rotem I, Tsai J, DePierro J, Pietrzak RH. J Psychiatr Res. 2020 Dec; 2020 Sep 23. PMID: 32998083.", + "Dissociative Symptoms in a Nationally Representative Sample of Trauma-Exposed U.S. Military Veterans: Prevalence, Comorbidities, and Suicidality. Herzog S, Fogle BM, Harpaz-Rotem I, Tsai J, Pietrzak RH. J Affect Disord. 2020 Jul 1; 2020 Apr 29. PMID: 32379605.", + "Randomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette Syndrome. Sukhodolsky DG, Walsh C, Koller WN, Eilbott J, Rance M, Fulbright RK, Zhao Z, Bloch MH, King R, Leckman JF, Scheinost D, Pittman B, Hampson M. Biol Psychiatry. 2020 Jun 15; 2019 Aug 13. PMID: 31668476.", + "Sex Differences in Associations Between Depression and Posttraumatic Stress Disorder Symptoms and Tobacco Use Among Veterans of Recent Conflicts. Gross GM, Bastian LA, Smith NB, Harpaz-Rotem I, Hoff R. J Womens Health (Larchmt). 2020 May; 2020 Jan 14. PMID: 31934813.", + "Courses of suicidal ideation among military veterans in residential treatment for posttraumatic stress disorder. Smith NB, Sippel LM, Rozek DC, Spangler PT, Traber D, Straud CL, Hoff R, Harpaz-Rotem I. Depress Anxiety. 2020 Mar; 2020 Jan 17. PMID: 31951318.", + "Comparing the effectiveness of VA residential PTSD treatment for veterans who do and do not report a history of MST: A national investigation. Holliday R, Smith NB, Holder N, Gross GM, Monteith LL, Maguen S, Hoff RA, Harpaz-Rotem I. J Psychiatr Res. 2020 Mar; 2019 Dec 20. PMID: 31923834.", + "Posttraumatic stress symptom courses in U.S. military veterans: A seven-year, nationally representative, prospective cohort study. Mota NP, Cook JM, Smith NB, Tsai J, Harpaz-Rotem I, Krystal JH, Southwick SM, Pietrzak RH. J Psychiatr Res. 2019 Dec; 2019 Sep 12. PMID: 31546045.", + "Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. Averill LA, Abdallah CG, Levey DF, Han S, Harpaz-Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Depress Anxiety. 2019 Sep; 2019 Aug 6. PMID: 31385647.", + "Heterogeneity of posttraumatic stress symptomatology and social connectedness in treatment-seeking military veterans: a longitudinal examination. Sippel LM, Watkins LE, Pietrzak RH, Hoff R, Harpaz-Rotem I. Eur J Psychotraumatol. 2019; 2019 Aug 9. PMID: 31489133.", + "Adoption by VA Residential Programs of Two Evidence-Based Psychotherapies for PTSD: Effect on Patient Outcomes. Cook JM, Schnurr PP, Simiola V, Thompson R, Hoff R, Harpaz-Rotem I. Psychiatr Serv. 2019 Jul 1; 2019 Apr 10. PMID: 30966944.", + "Randomized Controlled Trial of Imagery Rehearsal for Posttraumatic Nightmares in Combat Veterans. Harb GC, Cook JM, Phelps AJ, Gehrman PR, Forbes D, Localio R, Harpaz-Rotem I, Gur RC, Ross RJ. J Clin Sleep Med. 2019 May 15; 2019 May 15. PMID: 31053215.", + "Author Correction: Neural computations of threat in the aftermath of combat trauma. Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D. Nat Neurosci. 2019 May. PMID: 30760852.", + "Posttraumatic Stress Disorder Symptoms, Functioning, and Suicidal Ideation in US Military Veterans: A Symptomics Approach. Kachadourian LK, Harpaz-Rotem I, Tsai J, Southwick SM, Pietrzak RH. Prim Care Companion CNS Disord. 2019 Apr 25; 2019 Apr 25. PMID: 31050228.", + "Threat-related disorders as persistent motivational states of defense. Corchs F, Schiller D. Curr Opin Behav Sci. 2019 Apr; 2018 Oct 25. PMID: 31011592.", + "Examining the nonresponse phenomenon: Factors associated with treatment response in a national sample of veterans undergoing residential PTSD treatment. Sripada RK, Blow FC, Rauch SAM, Ganoczy D, Hoff R, Harpaz-Rotem I, Bohnert KM. J Anxiety Disord. 2019 Apr; 2019 Feb 7. PMID: 30785007.", + "Neural computations of threat in the aftermath of combat trauma. Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D. Nat Neurosci. 2019 Mar; 2019 Jan 21. PMID: 30664770.", + "Latent typologies of DSM-5 PTSD symptoms in U.S. military veterans. Byrne SP, Harpaz-Rotem I, Tsai J, Southwick SM, Pietrzak RH. Psychiatry Res. 2019 Mar; 2018 Dec 19. PMID: 30658212.", + "Protective correlates of suicidality among veterans with histories of posttraumatic stress disorder and major depressive disorder: Results from the National Health and Resilience in Veterans Study. Kachadourian LK, Tsai J, Harpaz-Rotem I, Southwick SM, Pietrzak RH. J Affect Disord. 2019 Mar 1; 2018 Dec 21. PMID: 30616162.", + "In Their Own Words: Clinician Experiences and Challenges in Administering Evidence-Based Treatments for PTSD in the Veterans Health Administration. Doran JM, O'Shea M, Harpaz-Rotem I. Psychiatr Q. 2019 Mar. PMID: 30209719.", + "Predictors of Dropout From Residential Treatment for Posttraumatic Stress Disorder Among Military Veterans. Smith NB, Sippel LM, Rozek DC, Hoff RA, Harpaz-Rotem I. Front Psychol. 2019; 2019 Feb 26. PMID: 30873081.", + "Contrasting contributions of anhedonia to obsessive-compulsive, hoarding, and post-traumatic stress disorders. Pushkarskaya H, Sobowale K, Henick D, Tolin DF, Anticevic A, Pearlson GD, Levy I, Harpaz-Rotem I, Pittenger C. J Psychiatr Res. 2019 Feb; 2018 Dec 1. PMID: 30572276.", + "", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Hayman Lab", + "lab_url": "https://medicine.yale.edu/lab/hayman/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/hayman/publications/", + "publications": [ + "Yale School of Medicine /", + "Therapeutic Radiology /", + "Research", + "Lab Members", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Lab Members", + "Publications", + "News", + "", + "", + "", + "", + "", + "", + "PLK4 Inhibition as a Strategy to Enhance Non-Small Cell Lung Cancer Radiosensitivity. Domínguez-Vigil IG, Banik K, Baro M, Contessa JN, Hayman TJ. Mol Cancer Ther. 2025 Sep 2. PMID: 40296663.", + "Role of PLK4 inhibition in cancer therapy. Banik K, Hayman TJ. Cancer Metastasis Rev. 2025 Jun 13; 2025 Jun 13. PMID: 40512236.", + "PLK4 inhibition as a strategy to enhance non-small cell lung cancer radiosensitivity. Dominguez-Vigil IG, Banik K, Baro M, Contessa JN, Hayman TJ. bioRxiv. 2025 Feb 23; 2025 Feb 23. PMID: 40027806.", + "Rethinking the use of germline CHEK2 mutation as a marker for PARP inhibitor sensitivity. Hayman TJ. JNCI Cancer Spectr. 2024 Jul 1. PMID: 38950525.", + "Radioresistant Pulmonary Oligometastatic and Oligoprogressive Lesions From Nonlung Primaries: Impact of Histology and Dose-Fractionation on Local Control After Radiation Therapy. Verma N, Laird JH, Moore NS, Hayman TJ, Housri N, Peters GW, Knowlton CA, Jairam V, Campbell AM, Park HS. Adv Radiat Oncol. 2024 Jun; 2024 Mar 21. PMID: 38699671.", + "Dose-Volume Predictors of Radiation Pneumonitis After Thoracic Hypofractionated Radiation Therapy. Sasse A, Oh P, Saeed N, Yang DX, Hayman TJ, Knowlton CA, Peters GW, Campbell A, Laird J, Housri N, Park HS. Pract Radiat Oncol. 2024 Mar-Apr; 2023 Nov 19. PMID: 37984711.", + "STING Agonists in Head and Neck Squamous Cell Carcinoma. Wallington DG, Contessa JN, Hayman TJ. Cancer J. 2022 Sep-Oct 01. PMID: 36165729.", + "Regulation of the Cell-Intrinsic DNA Damage Response by the Innate Immune Machinery. Hayman TJ, Glazer PM. Int J Mol Sci. 2021 Nov 25; 2021 Nov 25. PMID: 34884568.", + "Combinations of immunotherapy and radiation therapy in head and neck squamous cell carcinoma: a narrative review. Hayman TJ, Bhatia AK, Jethwa KR, Young MR, Park HS. Transl Cancer Res. 2021 May. PMID: 35116571.", + "STING enhances cell death through regulation of reactive oxygen species and DNA damage. Hayman TJ, Baro M, MacNeil T, Phoomak C, Aung TN, Cui W, Leach K, Iyer R, Challa S, Sandoval-Schaefer T, Burtness BA, Rimm DL, Contessa JN. Nat Commun. 2021 Apr 19; 2021 Apr 19. PMID: 33875663.", + "The translocon-associated protein (TRAP) complex regulates quality control of N-linked glycosylation during ER stress. Phoomak C, Cui W, Hayman TJ, Yu SH, Zhao P, Wells L, Steet R, Contessa JN. Sci Adv. 2021 Jan; 2021 Jan 15. PMID: 33523898.", + "CDKN2A Copy Number Loss Is an Independent Prognostic Factor in HPV-Negative Head and Neck Squamous Cell Carcinoma. Chen WS, Bindra RS, Mo A, Hayman T, Husain Z, Contessa JN, Gaffney SG, Townsend JP, Yu JB. Front Oncol. 2018; 2018 Apr 4. PMID: 29670856.", + "Outcomes of resected pancreatic cancer in patients age ≥70. Hayman TJ, Strom T, Springett GM, Balducci L, Hoffe SE, Meredith KL, Hodul P, Malafa M, Shridhar R. J Gastrointest Oncol. 2015 Oct. PMID: 26487943.", + "The mTORC1/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells. Kahn J, Hayman TJ, Jamal M, Rath BH, Kramp T, Camphausen K, Tofilon PJ. Neuro Oncol. 2014 Jan; 2013 Dec 4. PMID: 24311635.", + "The ATP-competitive mTOR inhibitor INK128 enhances in vitro and in vivo radiosensitivity of pancreatic carcinoma cells. Hayman TJ, Wahba A, Rath BH, Bae H, Kramp T, Shankavaram UT, Camphausen K, Tofilon PJ. Clin Cancer Res. 2014 Jan 1; 2013 Nov 6. PMID: 24198241.", + "Competitive but Not Allosteric mTOR Kinase Inhibition Enhances Tumor Cell Radiosensitivity. Hayman TJ, Kramp T, Kahn J, Jamal M, Camphausen K, Tofilon PJ. Transl Oncol. 2013 Jun; 2013 Jun 1. PMID: 23730416.", + "Body mass index and survival in esophageal adenocarcinoma treated with chemoradiotherapy followed by esophagectomy. Shridhar R, Hayman T, Hoffe SE, Weber J, Almhanna K, Chuong M, Karl RC, Meredith KL. J Gastrointest Surg. 2012 Jul; 2012 Mar 8. PMID: 22399271.", + "Translation initiation factor eIF4E is a target for tumor cell radiosensitization. Hayman TJ, Williams ES, Jamal M, Shankavaram UT, Camphausen K, Tofilon PJ. Cancer Res. 2012 May 1; 2012 Mar 7. PMID: 22397984.", + "Comparison of 1-, 2-, and 3-Dimensional Tumor Response Assessment After Neoadjuvant GTX-RT in Borderline-Resectable Pancreatic Cancer. Chuong MD, Hayman TJ, Patel MR, Russell MS, Malafa MP, Hodul PJ, Springett GM, Choi J, Shridhar R, Hoffe SE. Gastrointest Cancer Res. 2011 Jul. PMID: 22368736.", + "Hayman, T.J., Bhatia, A.K., Jethwa, K.R., Young, M.R. & Park, H.S. Combinations of immunotherapy and radiation therapy in head and neck squamous cell carcinoma: a narrative review. Translational Cancer Research (2020).", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Hepar Lab", + "lab_url": "https://medicine.yale.edu/lab/hepar/", + "research_bio": "INFORMATION FOR Our research is fueled by questions arising from clinical observations at the bedside of the patient and focuses on liver diseases. Diseases of the liver represent a major healthcare problem worldwide and the main causes of morbidity and mortality in the population between 45 and 55 years old. Unfortunately, the incidence of liver disease is expected to increase drastically. A number of liver conditions are preventable and treatable if the risk factors present in the individual are appropriately identified. However, for many patients with advanced liver disease the only possibility of treatment remains liver transplantation. Better understanding of the mechanisms of progression of liver damage will hopefully lead to more effective treatments. Micrograph of Sirius red-stained liver section from a Pkhd1del4/del4 mouse showing the extension of portal fibrosis. Confocal image showing the distribution of ZO-1 (in red), b-catenin (in green) and DAPI (blue) in human biliary organoids after apical-out polarity switch. Dual immunofluorescence staining showing the co-expression of the biliary marker CK7 (red) and the hepatocellular marker LKM-1 (green) in a human liver specimen from a patient with Alagille Syndrome. Confocal image of human iPSC-derived cholangiocyte monolayer showing the presence of apical primary cilia (acetylated alpha-tubulin) in green and the expression of the protein ZO-1 (in red) restricted at the apical cell junctions. Expression of biliary markers CK19 (green) and HNF1b (red) and DAPI nuclear staining (blue) in human iPSC-derived cholangiocytes.", + "publications_page": "https://medicine.yale.edu/lab/hepar/publications/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Digestive Diseases /", + "Research/Projects Biliary epithelial cell physiology and cholangiopathies Alagille syndrome (AGS) and Notch signaling Congenital Hepatic Fibrosis and Caroli Disease Cystic Fibrosis-related Liver Disease (CFLD) Polycystic Liver Disease Primary Sclerosing Cholangitis (PSC) Novel Cellular Models to Study Cholangiopathies Molecular Mechanisms of Cholangiocarcinoma Progression: Role of the Tumor Microenvironment Outcomes Research, Health Care Delivery and Technology Assessment", + "Biliary epithelial cell physiology and cholangiopathies Alagille syndrome (AGS) and Notch signaling Congenital Hepatic Fibrosis and Caroli Disease Cystic Fibrosis-related Liver Disease (CFLD) Polycystic Liver Disease Primary Sclerosing Cholangitis (PSC)", + "Alagille syndrome (AGS) and Notch signaling", + "Congenital Hepatic Fibrosis and Caroli Disease", + "Cystic Fibrosis-related Liver Disease (CFLD)", + "Polycystic Liver Disease", + "Primary Sclerosing Cholangitis (PSC)", + "Novel Cellular Models to Study Cholangiopathies", + "Molecular Mechanisms of Cholangiocarcinoma Progression: Role of the Tumor Microenvironment", + "Outcomes Research, Health Care Delivery and Technology Assessment", + "News", + "Faculty & Staff Alumni", + "Alumni", + "Publications", + "Lab Photos", + "Links", + "Acknowledgements", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research/Projects", + "Faculty & Staff", + "Lab Photos", + "Acknowledgements", + "News", + "Publications", + "Links", + "", + "", + "", + "", + "", + "", + "Type 2 diabetes remission after initiation of GLP-1 receptor agonists: frequency, characteristics, and outcomes using multiple definitions in an observational study. Fadini GP, Giaccari A, Broglio F, Nollino L, Fattor B, Anichini R, Meregalli G, Avogaro A, Consoli A. Lancet Reg Health Eur. 2025 Dec; 2025 Oct 15. PMID: 41142657.", + "Effectiveness of oral semaglutide versus empagliflozin for the management of type 2 diabetes. PIONEER-2 trial emulation with real-world data. Fadini GP, Longato E, Poletto S, Giaccari A, Ghiani M, Strazzabosco M, Trombetta M, Penno G, Avogaro A, Solini A, Consoli A. Diabetes Obes Metab. 2025 Dec; 2025 Sep 24. PMID: 40990044.", + "From hierarchy to conversion: A watermill approach to the therapeutic management of patients with hepatocellular carcinoma. Giannini EG, Dufour JF, Strazzabosco M. Dig Liver Dis. 2025 Oct; 2025 Aug 26. PMID: 40866140.", + "Sex differences in the weight response to GLP-1RA in people with type 2 diabetes. A long-term longitudinal real-world study. Marassi M, Cignarella A, Russo GT, Nollino L, Strazzabosco M, Marzullo P, Leonetti F, Avogaro A, Consoli A, Fadini GP. Pharmacol Res. 2025 Sep; 2025 Jul 22. PMID: 40706779.", + "Long-term preservation of kidney function with SGLT-2 inhibitors versus comparator drugs in people with type 2 diabetes and chronic kidney disease. Fadini GP, Longato E, Morieri ML, Broglio F, Aimaretti G, Russo GT, Anichini R, Ghiani M, Avogaro A, Solini A. Diabetes Obes Metab. 2025 Sep; 2025 Jul 2. PMID: 40600449.", + "Noninvasive Tumor Profiling: Quantitative Contrast-Enhanced MRI Markers Predict PD-L1 and CTNNB1 Status in Hepatocellular Carcinoma. Matuschewski NJ, Sobirey R, Revzin M, Zeevi T, Gross M, Kasolowsky V, Shewarega A, Meister E, Kao T, Tefera J, Bousabarah K, Batra R, Strazzabosco M, Lin M, Gebauer B, Savic LJ, Duncan J, Madoff DC, Zhang X, Chapiro J. Radiology. 2025 Aug. PMID: 40762840.", + "Hippocampal Subfields Volume: Another Hint of the Continuum Between CAA and AD? Storti B, Stanziano M, Marinoni G, Mazzè A, Francia A, Zacarias E, Strazzabosco C, De Toma C, Rifino N, Boncoraglio G, Di Fede G, Pollaci G, Gatti L, Canavero I, Bersano A. Eur J Neurol. 2025 Jul. PMID: 40626372.", + "Recommendations on Perihilar Cholangiocarcinoma. The Milan Jury-Based Consensus. Pfister M, Ratti F, Gores GJ, Lesurtel M, Chiche L, Ebata T, Ardiles V, Valle JW, Heimbach JK, Braconi C, Bruix J, Aldrighetti L, Clavien PA. Ann Surg. 2025 Jun 6; 2025 Jun 6. PMID: 40478744.", + "Effectiveness and safety of daily oral semaglutide in people with type 2 diabetes mellitus switching from sulfonylureas: A real-world retrospective study. Costa S, Miranda C, Elefante A, Vallone V, Vinci C, Borroni F, Brandoni G, Labate AM, Lo Pomo F, Strazzabosco M. Diabetes Obes Metab. 2025 Jun; 2025 Mar 6. PMID: 40045764.", + "PIONEER REAL Italy: Real-World Usage of Once-Daily Oral Semaglutide in Adults with Type 2 Diabetes. Manti R, De Cosmo S, Desenzani P, Ferrara L, Girelli A, Memoli G, Bisio A, Braae UC, Deinega A, Berra C. Diabetes Ther. 2025 May; 2025 Mar 25. PMID: 40128506.", + "Comparison of prognostic accuracy of HCC staging systems in patients undergoing TACE. Kasolowsky V, Gross M, Madoff DC, Duncan J, Taddei T, Strazzabosco M, Jaffe A, Chapiro J. Clin Imaging. 2025 Apr; 2025 Feb 25. PMID: 40049074.", + "Portal Fibrosis and the Ductular Reaction: Pathophysiological Role in the Progression of Liver Disease and Translational Opportunities. Gupta V, Sehrawat TS, Pinzani M, Strazzabosco M. Gastroenterology. 2025 Apr; 2024 Sep 7. PMID: 39251168.", + "Insights into Liposomal and Gel-Based Formulations for Dermatological Treatments. Strazzabosco G, Liboni A, Pezzi G, Alogna A, Bortolotti D. Gels. 2025 Mar 26; 2025 Mar 26. PMID: 40277680.", + "Characterisation and anaerobic digestion of fat, oil and grease (FOG) waste from wastewater treatment plants. Alibardi L, Strazzabosco A, Cossu R. J Environ Manage. 2025 Feb; 2025 Jan 24. PMID: 39862814.", + "Second-Line Treatment for Patients With Primary Biliary Cholangitis: A Systematic Review With Network Meta-Analysis. Giannini EG, Pasta A, Calabrese F, Labanca S, Marenco S, Pieri G, Plaz Torres MC, Strazzabosco M. Liver Int. 2025 Jan. PMID: 39720853.", + "Tumor response assessment in hepatocellular carcinoma treated with immunotherapy: imaging biomarkers for clinical decision-making. Sobirey R, Matuschewski N, Gross M, Lin M, Kao T, Kasolowsky V, Strazzabosco M, Stein S, Savic LJ, Gebauer B, Jaffe A, Duncan J, Madoff DC, Chapiro J. Eur Radiol. 2025 Jan; 2024 Jul 20. PMID: 39033181.", + "Editor's Note: Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma. Cadamuro M, Spagnuolo G, Sambado L, Indraccolo S, Nardo G, Rosato A, Brivio S, Caslini C, Stecca T, Massani M, Bassi N, Novelli E, Spirli C, Fabris L, Strazzabosco M. Cancer Res. 2024 Nov 15. PMID: 39544086.", + "Procoagulant phenotype of virus-infected pericytes is associated with portal thrombosis and intrapulmonary vascular dilations in fatal COVID-19. Cadamuro M, Lasagni A, Radu CM, Calistri A, Pilan M, Valle C, Bonaffini PA, Vitiello A, Toffanin S, Venturin C, Friòn-Herrera Y, Sironi S, Alessio MG, Previtali G, Seghezzi M, Gianatti A, Strazzabosco M, Strain AJ, Campello E, Spiezia L, Palù G, Frigo AC, Tosoni A, Nebuloni M, Parolin C, Sonzogni A, Simioni P, Fabris L. J Hepatol. 2024 Nov; 2024 Jun 20. PMID: 38908437.", + "Automated graded prognostic assessment for patients with hepatocellular carcinoma using machine learning. Gross M, Haider SP, Ze'evi T, Huber S, Arora S, Kucukkaya AS, Iseke S, Gebauer B, Fleckenstein F, Dewey M, Jaffe A, Strazzabosco M, Chapiro J, Onofrey JA. Eur Radiol. 2024 Oct; 2024 Mar 27. PMID: 38536464.", + "Prominent role of gut dysbiosis in the pathogenesis of cystic fibrosis-related liver disease in mice. Bertolini A, Nguyen M, Zehra SA, Taleb SA, Bauer-Pisani T, Palm N, Strazzabosco M, Fiorotto R. J Hepatol. 2024 Sep; 2024 Mar 28. PMID: 38554847.", + "Automated MRI liver segmentation for anatomical segmentation, liver volumetry, and the extraction of radiomics. Gross M, Huber S, Arora S, Ze'evi T, Haider SP, Kucukkaya AS, Iseke S, Kuhn TN, Gebauer B, Michallek F, Dewey M, Vilgrain V, Sartoris R, Ronot M, Jaffe A, Strazzabosco M, Chapiro J, Onofrey JA. Eur Radiol. 2024 Aug; 2024 Jan 13. PMID: 38217704.", + "Cost-effectiveness analysis: The missing factor in the management of HCC. Njei B, Yi I, Strazzabosco M. Clin Liver Dis (Hoboken). 2024 Jan-Jun; 2024 Jun 7. PMID: 38860130.", + "Safety and Efficacy of Atezolizumab/Bevacizumab in Patients with Hepatocellular Carcinoma and Impaired Liver Function: A Systematic Review and Meta-Analysis. Pasta A, Calabrese F, Jaffe A, Labanca S, Marenco S, Pieri G, Plaz Torres MC, Strazzabosco M, Giannini EG. Liver Cancer. 2024 Jun; 2023 Oct 14. PMID: 38756146.", + "Oral or injectable semaglutide for the management of type 2 diabetes in routine care: A multicentre observational study comparing matched cohorts. Fadini GP, Bonora BM, Ghiani M, Anichini R, Melchionda E, Fattor B, Fazion S, Meregalli G, Giaccari A, Avogaro A, Consoli A. Diabetes Obes Metab. 2024 Jun; 2024 Mar 13. PMID: 38477183.", + "Effectiveness of oral semaglutide on glucose control and body weight up to 18 months: a multicenter retrospective real-world study. Bonora BM, Russo G, Leonetti F, Strazzabosco M, Nollino L, Aimaretti G, Giaccari A, Broglio F, Consoli A, Avogaro A, Fadini GP. J Endocrinol Invest. 2024 Jun; 2024 Feb 18. PMID: 38369592.", + "Approach to immunotherapy for HCC in the liver transplant population. Block PD, Strazzabosco M, Jaffe A. Clin Liver Dis (Hoboken). 2024 Jan-Jun; 2024 May 3. PMID: 38707244.", + "It could happen in your backyard. Strazzabosco M. Hepatology. 2024 Apr 1; 2023 Sep 18. PMID: 37722133.", + "Prevalence and risk factors of glomerular hyperfiltration in adults with type 2 diabetes: A population-based study. Tricò D, Fadini GP, Morieri ML, Candido R, Disoteo OE, Frontoni S, Solini A. Diabetes Metab Res Rev. 2024 Mar. PMID: 38402454.", + "Comparison Between Moxifloxacin and Chloramphenicol for the Treatment of Bacterial Eye Infections. Gentili V, Strazzabosco G, Spena R, Rizzo S, Beltrami S, Schiuma G, Alogna A, Rizzo R. Curr Ther Res Clin Exp. 2024; 2024 Feb 28. PMID: 38511104.", + "Community-Level Factors Associated with Hepatocellular Carcinoma Incidence and Mortality: An Observational Registry Study. Mezzacappa C, Rossi R, Jaffe A, Taddei TH, Strazzabosco M. Cancer Epidemiol Biomarkers Prev. 2024 Feb 6. PMID: 38059831.", + "May we actually help clinicians select the best systemic treatment for patients with intermediate-stage hepatocellular carcinoma? Giannini EG, Strazzabosco M. Liver Int. 2024 Feb. PMID: 38289589.", + "European Society for Organ Transplantation (ESOT) Consensus Statement on Outcome Measures in Liver Transplantation According to Value-Based Health Care. Carbone M, Neuberger J, Rowe I, Polak WG, Forsberg A, Fondevila C, Mantovani L, Nardi A, Colli A, Rockell K, Schick L, Cristoferi L, Oniscu GC, Strazzabosco M, Cillo U. Transpl Int. 2023; 2024 Jan 25. PMID: 38332850.", + "HLA-DPA1*02:01~B1*01:01 is a risk haplotype for primary sclerosing cholangitis mediating activation of NKp44+ NK cells. Zecher BF, Ellinghaus D, Schloer S, Niehrs A, Padoan B, Baumdick ME, Yuki Y, Martin MP, Glow D, Schröder-Schwarz J, Niersch J, Brias S, Müller LM, Habermann R, Kretschmer P, Früh T, Dänekas J, Wehmeyer MH, Poch T, Sebode M, Ellinghaus E, Degenhardt F, Körner C, Hoelzemer A, Fehse B, Oldhafer KJ, Schumacher U, Sauter G, Carrington M, Franke A, Bunders MJ, Schramm C, Altfeld M. Gut. 2024 Jan 5; 2024 Jan 5. PMID: 37788895.", + "Clinical Features, Cardiovascular Risk Profile, and Therapeutic Trajectories of Patients with Type 2 Diabetes Candidate for Oral Semaglutide Therapy in the Italian Specialist Care. Morieri ML, Candido R, Frontoni S, Disoteo O, Solini A, Fadini GP. Diabetes Ther. 2023 Dec; 2023 Oct 18. PMID: 37848758.", + "Ozonated Oil in Liposome Eyedrops Reduces the Formation of Biofilm, Selection of Antibiotic-Resistant Bacteria, and Adhesion of Bacteria to Human Corneal Cells. Gentili V, Strazzabosco G, Salgari N, Mancini A, Rizzo S, Beltrami S, Schiuma G, Casciano F, Alogna A, Passarella D, Davinelli S, Scapagnini G, Medoro A, Rizzo R. Int J Mol Sci. 2023 Sep 14; 2023 Sep 14. PMID: 37762377.", + "Non-classical HLA class I molecules and their potential role in viral infections. Beltrami S, Rizzo S, Strazzabosco G, Gentili V, Alogna A, Narducci M, Bortolotti D, Schiuma G, Rizzo R. Hum Immunol. 2023 Aug; 2023 Mar 31. PMID: 37005169.", + "Short-term effectiveness of dapagliflozin versus DPP-4 inhibitors in elderly patients with type 2 diabetes: a multicentre retrospective study. Morieri ML, Raz I, Consoli A, Rigato M, Lapolla A, Broglio F, Bonora E, Avogaro A, Fadini GP. J Endocrinol Invest. 2023 Jul; 2023 Jan 9. PMID: 36624223.", + "Reply: Novel antidiabetic drugs and the risk for HCC. What else to expect from these \"wonderful\" drug classes? Plaz Torres MC, Jaffe A, Perry R, Marabotto E, Strazzabosco M, Giannini EG. Hepatology. 2023 Jun 1; 2023 Feb 3. PMID: 36724446.", + "Adherence to Tumor Board Recommendations in the Treatment of Patients with Hepatocellular Carcinoma. Cao Y, Mezzacappa C, Jaffe A, Strazzabosco M, Taddei TH. J Multidiscip Healthc. 2023; 2023 May 31. PMID: 37283950.", + "Fibroblasts to hepatocytes: A nonstop flight into cell therapy for liver diseases? Gouon-Evans V, Fiorotto R. Hepatology. 2023 May 1; 2023 Apr 17. PMID: 35957526.", + "Cell-matrix interactions control biliary organoid polarity, architecture, and differentiation. Fiorotto R, Mariotti V, Taleb SA, Zehra SA, Nguyen M, Amenduni M, Strazzabosco M. Hepatol Commun. 2023 Apr 1; 2023 Mar 24. PMID: 36972396.", + "Intrahepatic Cholangiocarcinoma Developing in Patients with Metabolic Syndrome Is Characterized by Osteopontin Overexpression in the Tumor Stroma. Cadamuro M, Sarcognato S, Camerotto R, Girardi N, Lasagni A, Zanus G, Cillo U, Gringeri E, Morana G, Strazzabosco M, Campello E, Simioni P, Guido M, Fabris L. Int J Mol Sci. 2023 Mar 1; 2023 Mar 1. PMID: 36902188.", + "Alternative HCC prognostic biomarkers and use of artificial intelligence in the management of HCC. Jaffe A, Taddei TH, Giannini EG, Ilagan-Ying YC, Colombo M, Strazzabosco M. Liver Int. 2023 Jan; 2022 Dec 5. PMID: 36426717.", + "Immune checkpoint inhibitors in malignancies after liver transplantation: A systematic review and pooled analysis. Kayali S, Pasta A, Plaz Torres MC, Jaffe A, Strazzabosco M, Marenco S, Giannini EG. Liver Int. 2023 Jan; 2022 Sep 27. PMID: 36102312.", + "Locoregional Therapy in the Management of Intrahepatic Cholangiocarcinoma: Is There Sufficient Evidence to Guide Current Clinical Practice? Wang Y, Strazzabosco M, Madoff DC. Curr Oncol Rep. 2022 Dec; 2022 Oct 18. PMID: 36255606.", + "Holistic management of hepatocellular carcinoma: The hepatologist's comprehensive playbook. Jaffe A, Taddei TH, Giannini EG, Ilagan-Ying YC, Colombo M, Strazzabosco M. Liver Int. 2022 Dec; 2022 Oct 11. PMID: 36161463.", + "Retracted: Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage. Hepatology. 2022 Dec; 2022 Jun 17. PMID: 35713384.", + "Diabetes medications and risk of HCC. Plaz Torres MC, Jaffe A, Perry R, Marabotto E, Strazzabosco M, Giannini EG. Hepatology. 2022 Dec; 2022 Mar 22. PMID: 35239194.", + "ESOT Consensus Platform for Organ Transplantation: Setting the Stage for a Rigorous, Regularly Updated Development Process. Cillo U, Weissenbacher A, Pengel L, Jochmans I, Roppolo D, Amarelli C, Belli LS, Berenguer M, De Vries A, Ferrer J, Friedewald J, Furian L, Greenwood S, Monbaliu D, Nadalin S, Neyrinck A, Strazzabosco M, Toso C, Zaza G, Thuraisingham R, Berney T, Potena L, Montserrat N, Selzner N. Transpl Int. 2022; 2022 Oct 24. PMID: 36406781.", + "Molecular determinants of peri-apical targeting of inositol 1,4,5-trisphosphate receptor type 3 in cholangiocytes. Rodrigues MA, Gomes DA, Fiorotto R, Guerra MT, Weerachayaphorn J, Bo T, Sessa WC, Strazzabosco M, Nathanson MH. Hepatol Commun. 2022 Oct; 2022 Jul 19. PMID: 35852334.", + "The Evolution of Ketosis: Potential Impact on Clinical Conditions. Dilliraj LN, Schiuma G, Lara D, Strazzabosco G, Clement J, Giovannini P, Trapella C, Narducci M, Rizzo R. Nutrients. 2022 Sep 1; 2022 Sep 1. PMID: 36079870.", + "Synthesis and NLRP3-Inflammasome Inhibitory Activity of the Naturally Occurring Velutone F and of Its Non-Natural Regioisomeric Chalconoids. De Ventura T, Perrone M, Missiroli S, Pinton P, Marchetti P, Strazzabosco G, Turrin G, Illuminati D, Cristofori V, Fantinati A, Fabbri M, Giorgi C, Trapella C, Zanirato V. Int J Mol Sci. 2022 Aug 11; 2022 Aug 11. PMID: 36012241.", + "Bile acids and their receptors: modulators and therapeutic targets in liver inflammation. Bertolini A, Fiorotto R, Strazzabosco M. Semin Immunopathol. 2022 Jul; 2022 Apr 12. PMID: 35415765.", + "Optimization of the BCLC Staging System for Locoregional Therapy for Hepatocellular Carcinoma by Using Quantitative Tumor Burden Imaging Biomarkers at MRI. Borde T, Nezami N, Laage Gaupp F, Savic LJ, Taddei T, Jaffe A, Strazzabosco M, Lin M, Duran R, Georgiades C, Hong K, Chapiro J. Radiology. 2022 Jul; 2022 Apr 12. PMID: 35412368.", + "Translational Value of Tumor-Associated Lymphangiogenesis in Cholangiocarcinoma. Cadamuro M, Romanzi A, Guido M, Sarcognato S, Cillo U, Gringeri E, Zanus G, Strazzabosco M, Simioni P, Villa E, Fabris L. J Pers Med. 2022 Jun 30; 2022 Jun 30. PMID: 35887583.", + "Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1(-/-) mouse model of congenital hepatic fibrosis. Fabris L, Milani C, Fiorotto R, Mariotti V, Kaffe E, Seller B, Sonzogni A, Strazzabosco M, Cadamuro M. FASEB J. 2022 Jun. PMID: 35593740.", + "Adjusting Barcelona Clinic Liver Cancer Staging System to the Evolving Landscape of Hepatocellular Carcinoma: A Look to the Future. Strazzabosco M, Cabibbo G, Colombo M. Gastroenterology. 2022 Jun; 2022 Feb 2. PMID: 35122767.", + "Corrigendum to 'An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs' [J Hepatol 2021;75(3):572-581]. Cordell HJ, Fryett JJ, Ueno K, Darlay R, Aiba Y, Hitomi Y, Kawashima M, Nishida N, Khor SS, Gervais O, Kawai Y, Nagasaki M, Tokunaga K, Tang R, Shi Y, Li Z, Juran BD, Atkinson EJ, Gerussi A, Carbone M, Asselta R, Cheung A, de Andrade M, Baras A, Horowitz J, Ferreira MAR, Sun D, Jones DE, Flack S, Spicer A, Mulcahy VL, Byun J, Han Y, Sandford RN, Lazaridis KN, Amos CI, Hirschfield GM, Seldin MF, Invernizzi P, Siminovitch KA, Ma X, Nakamura M, Mells GF. J Hepatol. 2022 Feb; 2021 Dec 9. PMID: 34895949.", + "The Neglected Role of Bile Duct Epithelial Cells in NASH. Cadamuro M, Lasagni A, Sarcognato S, Guido M, Fabris R, Strazzabosco M, Strain AJ, Simioni P, Villa E, Fabris L. Semin Liver Dis. 2022 Feb; 2021 Nov 18. PMID: 34794182.", + "Tumor microenvironment and immunology of cholangiocarcinoma. Cadamuro M, Fabris L, Zhang X, Strazzabosco M. Hepatoma Res. 2022; 2022 Mar 10. PMID: 39301518.", + "Inflammatory pathways and cholangiocarcinoma risk mechanisms and prevention. Cadamuro M, Strazzabosco M. Adv Cancer Res. 2022; 2022 Mar 10. PMID: 35961707.", + "GlicoPro, Novel Standardized and Sterile Snail Mucus Extract for Multi-Modulative Ocular Formulations: New Perspective in Dry Eye Disease Management. Mencucci R, Strazzabosco G, Cristofori V, Alogna A, Bortolotti D, Gafà R, Cennamo M, Favuzza E, Trapella C, Gentili V, Rizzo R. Pharmaceutics. 2021 Dec 13; 2021 Dec 13. PMID: 34959420.", + "Improved performance and consistency of deep learning 3D liver segmentation with heterogeneous cancer stages in magnetic resonance imaging. Gross M, Spektor M, Jaffe A, Kucukkaya AS, Iseke S, Haider SP, Strazzabosco M, Chapiro J, Onofrey JA. PLoS One. 2021; 2021 Dec 1. PMID: 34852007.", + "Increased sHLA-G Is Associated with Improved COVID-19 Outcome and Reduced Neutrophil Adhesion. Bortolotti D, Gentili V, Rizzo S, Schiuma G, Beltrami S, Spadaro S, Strazzabosco G, Campo G, Carosella ED, Papi A, Rizzo R, Contoli M. Viruses. 2021 Sep 17; 2021 Sep 17. PMID: 34578436.", + "Pathological characteristics of liver sinusoidal thrombosis in COVID-19 patients: A series of 43 cases. Kondo R, Kawaguchi N, McConnell MJ, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Sun Z, Utsumi T, Strazzabosco M, Iwakiri Y. Hepatol Res. 2021 Sep; 2021 Aug 2. PMID: 34260803.", + "An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs. Cordell HJ, Fryett JJ, Ueno K, Darlay R, Aiba Y, Hitomi Y, Kawashima M, Nishida N, Khor SS, Gervais O, Kawai Y, Nagasaki M, Tokunaga K, Tang R, Shi Y, Li Z, Juran BD, Atkinson EJ, Gerussi A, Carbone M, Asselta R, Cheung A, de Andrade M, Baras A, Horowitz J, Ferreira MAR, Sun D, Jones DE, Flack S, Spicer A, Mulcahy VL, Byan J, Han Y, Sandford RN, Lazaridis KN, Amos CI, Hirschfield GM, Seldin MF, Invernizzi P, Siminovitch KA, Ma X, Nakamura M, Mells GF. J Hepatol. 2021 Sep; 2021 May 23. PMID: 34033851.", + "Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy. McConnell MJ, Kawaguchi N, Kondo R, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Lee AI, Pine AB, Chun HJ, Zhang X, Fernandez-Hernando C, Qing H, Wang A, Price C, Sun Z, Utsumi T, Hwa J, Strazzabosco M, Iwakiri Y. J Hepatol. 2021 Sep; 2021 May 13. PMID: 33991637.", + "TLR3 and TLR7 RNA Sensor Activation during SARS-CoV-2 Infection. Bortolotti D, Gentili V, Rizzo S, Schiuma G, Beltrami S, Strazzabosco G, Fernandez M, Caccuri F, Caruso A, Rizzo R. Microorganisms. 2021 Aug 26; 2021 Aug 26. PMID: 34576716.", + "Design of Liposomes Carrying HelixComplex Snail Mucus: Preliminary Studies. Alogna A, Gentili V, Trapella C, Hallan SS, Sguizzato M, Strazzabosco G, Fernández M, Cortesi R, Rizzo R, Bortolotti D. Molecules. 2021 Aug 4; 2021 Aug 4. PMID: 34443296.", + "Thermal ablation alone vs thermal ablation combined with transarterial chemoembolization for patients with small (<3 cm) hepatocellular carcinoma. Chai NX, Chapiro J, Petukhova A, Gross M, Kucukkaya A, Raju R, Zeevi T, Elbanan M, Lin M, Perez-Lozada JC, Schlachter T, Strazzabosco M, Pollak JS, Madoff DC. Clin Imaging. 2021 Aug; 2021 Feb 11. PMID: 33592550.", + "New insights on the role of vascular endothelial growth factor in biliary pathophysiology. Mariotti V, Fiorotto R, Cadamuro M, Fabris L, Strazzabosco M. JHEP Rep. 2021 Jun; 2021 Feb 4. PMID: 34151244.", + "X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis. Asselta R, Paraboschi EM, Gerussi A, Cordell HJ, Mells GF, Sandford RN, Jones DE, Nakamura M, Ueno K, Hitomi Y, Kawashima M, Nishida N, Tokunaga K, Nagasaki M, Tanaka A, Tang R, Li Z, Shi Y, Liu X, Xiong M, Hirschfield G, Siminovitch KA, Carbone M, Cardamone G, Duga S, Gershwin ME, Seldin MF, Invernizzi P. Gastroenterology. 2021 Jun; 2021 Mar 4. PMID: 33675743.", + "Reliable prediction of survival in advanced-stage hepatocellular carcinoma treated with sorafenib: comparing 1D and 3D quantitative tumor response criteria on MRI. Doemel LA, Chapiro J, Laage Gaupp F, Savic LJ, Kucukkaya AS, Petukhova A, Tefera J, Zeevi T, Lin M, Schlachter T, Jaffe A, Strazzabosco M, Patel T, Stein SM. Eur Radiol. 2021 May; 2020 Oct 30. PMID: 33123796.", + "Fibrocystic liver disease: novel concepts and translational perspectives. Lasagni A, Cadamuro M, Morana G, Fabris L, Strazzabosco M. Transl Gastroenterol Hepatol. 2021; 2021 Apr 5. PMID: 33824930.", + "Novel approaches to liver disease diagnosis and modeling. Oliveira AG, Fiorotto R. Transl Gastroenterol Hepatol. 2021; 2021 Apr 5. PMID: 33824923.", + "Rare and undiagnosed liver diseases: challenges and opportunities. Fabris L, Strazzabosco M. Transl Gastroenterol Hepatol. 2021; 2021 Apr 5. PMID: 33824922.", + "Targeted therapies for extrahepatic cholangiocarcinoma: preclinical and clinical development and prospects for the clinic. Cadamuro M, Lasagni A, Lamarca A, Fouassier L, Guido M, Sarcognato S, Gringeri E, Cillo U, Strazzabosco M, Marin JJ, Banales JM, Fabris L. Expert Opin Investig Drugs. 2021 Apr; 2021 Feb 23. PMID: 33622120.", + "IL-17A/F enable cholangiocytes to restrict T cell-driven experimental cholangitis by upregulating PD-L1 expression. Stein S, Henze L, Poch T, Carambia A, Krech T, Preti M, Schuran FA, Reich M, Keitel V, Fiorotto R, Strazzabosco M, Fischer L, Li J, Müller LM, Wagner J, Gagliani N, Herkel J, Schwinge D, Schramm C. J Hepatol. 2021 Apr; 2020 Nov 13. PMID: 33197512.", + "Intrahepatic cholangiocarcinoma: Morpho-molecular pathology, tumor reactive microenvironment, and malignant progression. Sirica AE, Strazzabosco M, Cadamuro M. Adv Cancer Res. 2021; 2020 Dec 9. PMID: 33579427.", + "The Tumor Microenvironment in Cholangiocarcinoma Progression. Fabris L, Sato K, Alpini G, Strazzabosco M. Hepatology. 2021 Jan; 2020 Nov 6. PMID: 32500550.", + "Health related quality of life in chronic liver diseases. Cortesi PA, Conti S, Scalone L, Jaffe A, Ciaccio A, Okolicsanyi S, Rota M, Fabris L, Colledan M, Fagiuoli S, Belli LS, Cesana G, Strazzabosco M, Mantovani LG. Liver Int. 2020 Nov. PMID: 32851764.", + "Abnormal Liver Function Tests in Patients With COVID-19: Relevance and Potential Pathogenesis. Bertolini A, van de Peppel IP, Bodewes FAJA, Moshage H, Fantin A, Farinati F, Fiorotto R, Jonker JW, Strazzabosco M, Verkade HJ, Peserico G. Hepatology. 2020 Nov; 2020 Oct 20. PMID: 32702162.", + "Value-based medicine, a compass to guide healthcare decisions in the COVID-19 aftermath. Strazzabosco M. Liver Int. 2020 Sep. PMID: 32677111.", + "Cholangiocarcinoma 2020: the next horizon in mechanisms and management. Banales JM, Marin JJG, Lamarca A, Rodrigues PM, Khan SA, Roberts LR, Cardinale V, Carpino G, Andersen JB, Braconi C, Calvisi DF, Perugorria MJ, Fabris L, Boulter L, Macias RIR, Gaudio E, Alvaro D, Gradilone SA, Strazzabosco M, Marzioni M, Coulouarn C, Fouassier L, Raggi C, Invernizzi P, Mertens JC, Moncsek A, Ilyas SI, Heimbach J, Koerkamp BG, Bruix J, Forner A, Bridgewater J, Valle JW, Gores GJ. Nat Rev Gastroenterol Hepatol. 2020 Sep; 2020 Jun 30. PMID: 32606456.", + "Liver Matrix in Benign and Malignant Biliary Tract Disease. Fabris L, Cadamuro M, Cagnin S, Strazzabosco M, Gores GJ. Semin Liver Dis. 2020 Aug; 2020 Mar 11. PMID: 32162285.", + "Surveillance for Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease: Universal or Selective? Plaz Torres MC, Bodini G, Furnari M, Marabotto E, Zentilin P, Strazzabosco M, Giannini EG. Cancers (Basel). 2020 May 31; 2020 May 31. PMID: 32486355.", + "The Emerging Role of Macrophages in Chronic Cholangiopathies Featuring Biliary Fibrosis: An Attractive Therapeutic Target for Orphan Diseases. Cadamuro M, Girardi N, Gores GJ, Strazzabosco M, Fabris L. Front Med (Lausanne). 2020; 2020 Apr 21. PMID: 32373615.", + "Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview. Torres S, Abdullah Z, Brol MJ, Hellerbrand C, Fernandez M, Fiorotto R, Klein S, Königshofer P, Liedtke C, Lotersztajn S, Nevzorova YA, Schierwagen R, Reiberger T, Uschner FE, Tacke F, Weiskirchen R, Trebicka J. Int J Mol Sci. 2020 Mar 16; 2020 Mar 16. PMID: 32188134.", + "Clinical outcome indicators in chronic hepatitis B and C: A primer for value-based medicine in hepatology. Strazzabosco M, Cortesi PA, Conti S, Okolicsanyi S, Rota M, Ciaccio A, Cozzolino P, Fornari C, Gemma M, Scalone L, Cesana G, Fabris L, Colledan M, Fagiuoli S, Ideo G, Zavaglia C, Perricone G, Munari LM, Mantovani LG, Belli LS. Liver Int. 2020 Jan; 2019 Nov 12. PMID: 31654608.", + "The challenges of primary biliary cholangitis: What is new and what needs to be done. Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D, Vierling JM, Adams D, Alpini G, Banales JM, Beuers U, Björnsson E, Bowlus C, Carbone M, Chazouillères O, Dalekos G, De Gottardi A, Harada K, Hirschfield G, Invernizzi P, Jones D, Krawitt E, Lanzavecchia A, Lian ZX, Ma X, Manns M, Mavilio D, Quigley EM, Sallusto F, Shimoda S, Strazzabosco M, Swain M, Tanaka A, Trauner M, Tsuneyama K, Zigmond E, Gershwin ME. J Autoimmun. 2019 Dec; 2019 Sep 20. PMID: 31548157.", + "Solar PV adoption in wastewater treatment plants: A review of practice in California. Strazzabosco A, Kenway SJ, Lant PA. J Environ Manage. 2019 Oct 15; 2019 Aug 3. PMID: 31386989.", + "Modeling of implementation of the new Organ Procurement and Transplantation Network/United Network for Organ Sharing policy for patients with hepatocellular carcinoma. Kokabi N, Nezami N, Xing M, Ludwig JM, Strazzabosco M, Kim HS. J Comp Eff Res. 2019 Sep; 2019 Sep 12. PMID: 31512955.", + "Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases. Fabris L, Fiorotto R, Spirli C, Cadamuro M, Mariotti V, Perugorria MJ, Banales JM, Strazzabosco M. Nat Rev Gastroenterol Hepatol. 2019 Aug. PMID: 31165788.", + "The tumour microenvironment and immune milieu of cholangiocarcinoma. Fabris L, Perugorria MJ, Mertens J, Björkström NK, Cramer T, Lleo A, Solinas A, Sänger H, Lukacs-Kornek V, Moncsek A, Siebenhüner A, Strazzabosco M. Liver Int. 2019 May. PMID: 30907492.", + "Cholangiocyte pathobiology. Banales JM, Huebert RC, Karlsen T, Strazzabosco M, LaRusso NF, Gores GJ. Nat Rev Gastroenterol Hepatol. 2019 May. PMID: 30850822.", + "Animal models of cholestasis: An update on inflammatory cholangiopathies. Mariotti V, Cadamuro M, Spirli C, Fiorotto R, Strazzabosco M, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Aug 11. PMID: 30398152.", + "Liver diseases in the dish: iPSC and organoids as a new approach to modeling liver diseases. Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Sep 5. PMID: 30264693.", + "Animal models for cystic fibrosis liver disease (CFLD). Fiorotto R, Amenduni M, Mariotti V, Cadamuro M, Fabris L, Spirli C, Strazzabosco M. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Jul 30. PMID: 30071276.", + "Platelet-derived growth factor-D enables liver myofibroblasts to promote tumor lymphangiogenesis in cholangiocarcinoma. Cadamuro M, Brivio S, Mertens J, Vismara M, Moncsek A, Milani C, Fingas C, Cristina Malerba M, Nardo G, Dall'Olmo L, Milani E, Mariotti V, Stecca T, Massani M, Spirli C, Fiorotto R, Indraccolo S, Strazzabosco M, Fabris L. J Hepatol. 2019 Apr; 2018 Dec 14. PMID: 30553841.", + "Intrahepatic Cholangiocarcinoma: Continuing Challenges and Translational Advances. Sirica AE, Gores GJ, Groopman JD, Selaru FM, Strazzabosco M, Wei Wang X, Zhu AX. Hepatology. 2019 Apr; 2019 Mar 25. PMID: 30251463.", + "Maps & Directions", + "3 Events you could attend in November 2025 Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Herold Lab", + "lab_url": "https://medicine.yale.edu/lab/herold/", + "research_bio": "INFORMATION FOR Our laboratory studies autoimmune diseases, whether they occur naturally or as a consequence of immunomodulator therapy. A perennial focus of the lab is type 1 diabetes, which results from autoimmune destruction of the pancreas. We are identifying the immune cells responsible for attacking the pancreatic islets, as well as studying how beta cells respond to these attacks. We now have new tools to manipulate the immune system, aimed at early-onset diabetes in both mouse models and human subjects, with the ultimate goal to stop disease before it progresses to permanent organ damage. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/herold/publications", + "publications": [ + "Yale School of Medicine /", + "Immunobiology /", + "Research", + "Publications", + "Image Gallery", + "People", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Publications", + "Image Gallery", + "People", + "", + "", + "", + "", + "", + "", + "CTLA-4 blockade shifts the B cell repertoire toward autoimmunity. Çakan E, Wang M, Dai Y, Mirouse A, Villanueva-Pachas CR, Bouis D, Boeckers JM, Gera R, Yraita S, Clapp L, Perdigoto AL, Delmotte FR, Massad C, Bacchiocchi A, Ring AM, Kluger Y, Kluger HM, Herold KC, Meffre E. J Clin Invest. 2025 Nov 17; 2025 Sep 30. PMID: 41026527.", + "Toward Disease-Modifying Therapies in Type 1 Diabetes: Focus on Teplizumab. Mathieu C, Sims EK, Chatenoud L, James EA, Atkinson MA, Herold KC. Diabetes Care. 2025 Nov 6; 2025 Nov 6. PMID: 41196630.", + "The Pathogenesis of Type 1 Diabetes. Herold KC, Krischer JP. Cold Spring Harb Perspect Med. 2025 Nov 3; 2025 Nov 3. PMID: 39134388.", + "Novel Approach for Assessing Outcomes of Type 1 Diabetes Prevention Trials Over a Fixed Time Interval. Sims EK, Russell WE, Cuthbertson D, Skyler JS, Jacobsen LM, Ismail HM, Redondo MJ, Nathan BM, Carr ALJ, Taylor PN, Dayan CM, Galderisi A, Herold KC, Sosenko JM. Diabetes. 2025 Nov 1. PMID: 40877213.", + "The Teplizumab Saga: The Challenge of Not Getting Lost in Clinical Translation. Chatenoud L, Herold KC, Bach JF, Bluestone JA. Cold Spring Harb Perspect Med. 2025 Oct 1; 2025 Oct 1. PMID: 39284671.", + "Reversing Diabetes With Your Own Cells: Closer to the Dream. Genosar R, Coman MM, Herold KC. J Clin Endocrinol Metab. 2025 Sep 16. PMID: 39673177.", + "Factors that increase class I MHC expression may contribute to the development of immune checkpoint inhibitor-induced diabetes. Aizenbud L, Savion Gaiger N, Perdigoto AL, Mann JE, Torres MC, Boland GM, Lawless AR, Silverman S, Schoenfeld DA, Destina JI, Hasson N, Tran T, Hurwitz M, Austin MR, Sullivan RJ, Herold KC, Kluger HM. J Immunother Cancer. 2025 Sep 10; 2025 Sep 10. PMID: 40935567.", + "Replacement of Beta Cells for Type 1 Diabetes. Herold KC, Pober JS. N Engl J Med. 2025 Sep 4. PMID: 40902169.", + "Autoimmune origin for immune checkpoint inhibitor-diabetes revealed by deep immune phenotyping of the pancreas. Quandt Z, Young A, Barlow GL, Smith JA, Kusmartseva I, Dong S, Shapiro MR, Kang JH, Felton JL, Nguyen VQ, Szot G, Hassoun AA, Perdigoto AL, Herold KC, Nolan G, Bollyky PL, Brusko TM, Nakayama M, Cooper S, Anderson MS. J Immunother Cancer. 2025 Aug 14; 2025 Aug 14. PMID: 40813111.", + "Humoral determinants of checkpoint immunotherapy. Dai Y, Aizenbud L, Qin K, Austin M, Jaycox JR, Cunningham J, Wang EY, Zhang L, Fischer S, Carroll SM, van Aggelen H, Kluger Y, Herold KC, Furchtgott L, Kluger HM, Ring AM. Nature. 2025 Aug; 2025 Jul 23. PMID: 40702172.", + "Moving the Goalposts Closer: Using Intermediate End Points in Type 1 Diabetes Prevention Trials. Sydney GI, Wu SS, Herold KC. Diabetes Care. 2025 Aug 1. PMID: 40690655.", + "Type 1 Diabetes TrialNet: Leading the Charge in Disease Prediction, Prevention, and Immunotherapeutic Mechanistic Understanding. Jacobsen LM, Felton JL, Nathan BM, Speake C, Krischer J, Herold KC. Diabetes Care. 2025 Jul 1. PMID: 40272284.", + "Latent EBV enhances the efficacy of anti-CD3 mAb in Type 1 diabetes. Lledó-Delgado A, Preston-Hurlburt P, Higdon L, Hu A, James E, Lim N, Long SA, McNamara J, Nguyen H, Serti E, Sumida TS, Herold KC. Nat Commun. 2025 May 30; 2025 May 30. PMID: 40447640.", + "Associations between immune checkpoint inhibitor response, immune-related adverse events, and steroid use in RADIOHEAD: a prospective pan-tumor cohort study. Quandt Z, Lucas A, Liang SI, Yang E, Stone S, Fadlullah MZH, Bayless NL, Marr SS, Thompson MA, Padron LJ, Bucktrout S, Butterfield LH, Tan AC, Herold KC, Bluestone JA, Anderson MS, Spencer CN, Young A, Connolly JE. J Immunother Cancer. 2025 May 12; 2025 May 12. PMID: 40355283.", + "Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease. Quandt Z, Perdigoto A, Anderson MS, Herold KC. Cold Spring Harb Perspect Med. 2025 Apr 1; 2025 Apr 1. PMID: 39038853.", + "A Glucose Fraction Independent of Insulin Secretion: Implications for Type 1 Diabetes Progression in Autoantibody-Positive Cohorts. Sosenko JM, Cuthbertson D, Jacobsen LM, Redondo MJ, Sims EK, Ismail HM, Herold KC, Skyler JS, Nathan BM. Diabetes Technol Ther. 2025 Mar; 2025 Jan 6. PMID: 39757867.", + "Characteristics of autoantibody-positive individuals without high-risk HLA-DR4-DQ8 or HLA-DR3-DQ2 haplotypes. Redondo MJ, Cuthbertson D, Steck AK, Herold KC, Oram R, Atkinson M, Brusko TM, Parikh HM, Krischer JP, Onengut-Gumuscu S, Rich SS, Sosenko JM. Diabetologia. 2025 Mar; 2024 Dec 13. PMID: 39670998.", + "Trajectory of beta cell function and insulin clearance in stage 2 type 1 diabetes: natural history and response to teplizumab. Galderisi A, Sims EK, Evans-Molina C, Petrelli A, Cuthbertson D, Nathan BM, Ismail HM, Herold KC, Moran A. Diabetologia. 2025 Mar; 2024 Nov 19. PMID: 39560746.", + "Type 1 Diabetes: Advances in Understanding and Treatment 100 Years after the Discovery of Insulin. Bluestone JA, Herold KC, Sussel L. Cold Spring Harb Perspect Med. 2025 Feb 10; 2025 Feb 10. PMID: 39929731.", + "Evolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus Interagency Coordinating Committee Workshop. Greenbaum CJ, Nepom GT, Wood-Heickman LK, Wherrett DK, DiMeglio LA, Herold KC, Krischer JP. Diabetes. 2024 Nov 1. PMID: 39167668.", + "Teplizumab induces persistent changes in the antigen-specific repertoire in individuals at risk for type 1 diabetes. Lledó-Delgado A, Preston-Hurlburt P, Currie S, Clark P, Linsley PS, Long SA, Liu C, Koroleva G, Martins AJ, Tsang JS, Herold KC. J Clin Invest. 2024 Aug 13; 2024 Aug 13. PMID: 39137044.", + "Comparisons of Metabolic Measures to Predict T1D vs Detect a Preventive Treatment Effect in High-Risk Individuals. Sims EK, Cuthbertson D, Jacobsen L, Ismail HM, Nathan BM, Herold KC, Redondo MJ, Sosenko J. J Clin Endocrinol Metab. 2024 Jul 12. PMID: 38267821.", + "Prevention of Type 1 Diabetes. Jacobsen LM, Schatz DA, Herold KC, Skyler JS. 2023. PMID: 38843373.", + "Early Metabolic Endpoints Identify Persistent Treatment Efficacy in Recent-Onset Type 1 Diabetes Immunotherapy Trials. Jacobsen LM, Cuthbertson D, Bundy BN, Atkinson MA, Moore W, Haller MJ, Russell WE, Gitelman SE, Herold KC, Redondo MJ, Sims EK, Wherrett DK, Moran A, Pugliese A, Gottlieb PA, Sosenko JM, Ismail HM. Diabetes Care. 2024 Jun 1. PMID: 38621411.", + "Evidence for C-Peptide as a Validated Surrogate to Predict Clinical Benefits in Trials of Disease-Modifying Therapies for Type 1 Diabetes. Latres E, Greenbaum CJ, Oyaski ML, Dayan CM, Colhoun HM, Lachin JM, Skyler JS, Rickels MR, Ahmed ST, Dutta S, Herold KC, Marinac M. Diabetes. 2024 Jun 1. PMID: 38349844.", + "The immunology of type 1 diabetes. Herold KC, Delong T, Perdigoto AL, Biru N, Brusko TM, Walker LSK. Nat Rev Immunol. 2024 Jun; 2024 Feb 2. PMID: 38308004.", + "A phase 2 randomized trial with autologous polyclonal expanded regulatory T cells in children with new-onset type 1 diabetes. Bender C, Wiedeman AE, Hu A, Ylescupidez A, Sietsema WK, Herold KC, Griffin KJ, Gitelman SE, Long SA. Sci Transl Med. 2024 May 8; 2024 May 8. PMID: 38718135.", + "Peri-Transplant Inflammation and Long-Term Diabetes Outcomes Were Not Impacted by Either Etanercept or Alpha-1-Antitrypsin Treatment in Islet Autotransplant Recipients. Abdel-Karim TR, Hodges JS, Herold KC, Pruett TL, Ramanathan KV, Hering BJ, Dunn TB, Kirchner VA, Beilman GJ, Bellin MD. Transpl Int. 2024; 2024 Jan 31. PMID: 38357216.", + "A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab. Mathieu C, Wiedeman A, Cerosaletti K, Long SA, Serti E, Cooney L, Vermeiren J, Caluwaerts S, Van Huynegem K, Steidler L, Blomme S, Rottiers P, Nepom GT, Herold KC. Diabetologia. 2024 Jan; 2023 Oct 2. PMID: 37782353.", + "Teplizumab and β-Cell Function in Newly Diagnosed Type 1 Diabetes. Ramos EL, Dayan CM, Chatenoud L, Sumnik Z, Simmons KM, Szypowska A, Gitelman SE, Knecht LA, Niemoeller E, Tian W, Herold KC. N Engl J Med. 2023 Dec 7; 2023 Oct 18. PMID: 37861217.", + "High proinsulin:C-peptide ratio identifies individuals with stage 2 type 1 diabetes at high risk for progression to clinical diagnosis and responses to teplizumab treatment. Sims EK, Geyer SM, Long SA, Herold KC. Diabetologia. 2023 Dec; 2023 Sep 4. PMID: 37667106.", + "Response to Comment on Russell et al. Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial. Diabetes Care 2023;46:1005-1013. Russell WE, Moore DJ, Herold KC. Diabetes Care. 2023 Nov 1. PMID: 37890101.", + "Hydroxychloroquine in Stage 1 Type 1 Diabetes. Libman I, Bingley PJ, Becker D, Buckner JH, DiMeglio LA, Gitelman SE, Greenbaum C, Haller MJ, Ismail HM, Krischer J, Moore WV, Moran A, Muir AB, Raman V, Steck AK, Toledo FGS, Wentworth J, Wherrett D, White P, You L, Herold KC. Diabetes Care. 2023 Nov 1. PMID: 37708415.", + "Immune responses to gut bacteria associated with time to diagnosis and clinical response to T cell-directed therapy for type 1 diabetes prevention. Xie QY, Oh S, Wong A, Yau C, Herold KC, Danska JS. Sci Transl Med. 2023 Oct 25; 2023 Oct 25. PMID: 37878676.", + "Teplizumab: A Disease-Modifying Therapy for Type 1 Diabetes That Preserves β-Cell Function. Herold KC, Gitelman SE, Gottlieb PA, Knecht LA, Raymond R, Ramos EL. Diabetes Care. 2023 Oct 1. PMID: 37607392.", + "Incidence, characteristics, risk factors and outcomes of diabetic ketoacidosis in COVID-19 patients: Comparison with influenza and pre-pandemic data. Dell'Aquila K, Lee J, Wang SH, Alamuri TT, Jennings R, Tang H, Mahesh S, Leong TJ, Fleysher R, Henninger EM, Veeraraghavan S, Mirhaji P, Hou W, Herold KC, Duong TQ. Diabetes Obes Metab. 2023 Sep; 2023 May 30. PMID: 37254311.", + "ScRNA-seq defines dynamic T-cell subsets in longitudinal colon and peripheral blood samples in immune checkpoint inhibitor-induced colitis. Mann JE, Lucca L, Austin MR, Merkin RD, Robert ME, Al Bawardy B, Raddassi K, Aizenbud L, Joshi NS, Hafler DA, Abraham C, Herold KC, Kluger HM. J Immunother Cancer. 2023 Aug. PMID: 37586769.", + "Latent EBV impairs immune cell signaling and enhances the efficacy of anti-CD3 mAb in Type 1 Diabetes. Delgado AL, Preston-Hurlburt P, Lim N, Sumida TS, Long SA, McNamara J, Serti E, Higdon L, Herold KC. medRxiv. 2023 Jul 13; 2023 Jul 13. PMID: 37502867.", + "Response to \"NLRC5 germline variants and their potential role in eliciting an immune response in patients with cancer treated with immune checkpoint inhibitors\" by Xiang-Yu Meng. Aizenbud L, Schoenfeld DA, Caulfield JI, Mann JE, Austin MR, Perdigoto AL, Herold KC, Kluger HM. J Immunother Cancer. 2023 Jun. PMID: 37349129.", + "HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal. Pierce CA, Loh LN, Steach HR, Cheshenko N, Preston-Hurlburt P, Zhang F, Stransky S, Kravets L, Sidoli S, Philbrick W, Nassar M, Krishnaswamy S, Herold KC, Herold BC. J Clin Invest. 2023 Jun 1; 2023 Jun 1. PMID: 37079384.", + "Phenotypes Associated With Zones Defined by Area Under the Curve Glucose and C-peptide in a Population With Islet Autoantibodies. Sosenko JM, Cuthbertson D, Sims EK, Ismail HM, Nathan BM, Jacobsen LM, Atkinson MA, Evans-Molina C, Herold KC, Skyler JS, Redondo MJ. Diabetes Care. 2023 May 1. PMID: 37000695.", + "Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial. Russell WE, Bundy BN, Anderson MS, Cooney LA, Gitelman SE, Goland RS, Gottlieb PA, Greenbaum CJ, Haller MJ, Krischer JP, Libman IM, Linsley PS, Long SA, Lord SM, Moore DJ, Moore WV, Moran AM, Muir AB, Raskin P, Skyler JS, Wentworth JM, Wherrett DK, Wilson DM, Ziegler AG, Herold KC. Diabetes Care. 2023 May 1. PMID: 36920087.", + "Incidence of new-onset in-hospital and persistent diabetes in COVID-19 patients: comparison with influenza. Lu JY, Wilson J, Hou W, Fleysher R, Herold BC, Herold KC, Duong TQ. EBioMedicine. 2023 Apr; 2023 Feb 28. PMID: 36857969.", + "Germline genetic variants are associated with development of insulin-dependent diabetes in cancer patients treated with immune checkpoint inhibitors. Caulfield JI, Aizenbud L, Perdigoto AL, Meffre E, Jilaveanu L, Michalek DA, Rich SS, Aizenbud Y, Adeniran A, Herold KC, Austin MR, Kluger H. J Immunother Cancer. 2023 Mar. PMID: 36898736.", + "CGM Metrics Identify Dysglycemic States in Participants From the TrialNet Pathway to Prevention Study. Wilson DM, Pietropaolo SL, Acevedo-Calado M, Huang S, Anyaiwe D, Scheinker D, Steck AK, Vasudevan MM, McKay SV, Sherr JL, Herold KC, Dunne JL, Greenbaum CJ, Lord SM, Haller MJ, Schatz DA, Atkinson MA, Nelson PW, Pietropaolo M. Diabetes Care. 2023 Mar 1. PMID: 36730530.", + "Barriers to Screening: An Analysis of Factors Impacting Screening for Type 1 Diabetes Prevention Trials. Kinney M, You L, Sims EK, Wherrett D, Schatz D, Lord S, Krischer J, Russell WE, Gottlieb PA, Libman I, Buckner J, DiMeglio LA, Herold KC, Steck AK. J Endocr Soc. 2023 Jan 6; 2023 Jan 11. PMID: 36741943.", + "Persistence of β-Cell Responsiveness for Over Two Years in Autoantibody-Positive Children With Marked Metabolic Impairment at Screening. Sims EK, Cuthbertson D, Felton JL, Ismail HM, Nathan BM, Jacobsen LM, Paprocki E, Pugliese A, Palmer J, Atkinson M, Evans-Molina C, Skyler JS, Redondo MJ, Herold KC, Sosenko JM. Diabetes Care. 2022 Dec 1. PMID: 36326757.", + "RAGE antagonism with azeliragon improves xenograft rejection by T cells in humanized mice. Joshi AA, Wu Y, Deng S, Preston-Hurlburt P, Forbes JM, Herold KC. Clin Immunol. 2022 Dec; 2022 Oct 17. PMID: 36257528.", + "Erratum. Innovative Designs and Logistical Considerations for Expedited Clinical Development of Combination Disease-Modifying Treatments for Type 1 Diabetes. Diabetes Care 2022;45:2189-2201. Anderson RL, DiMeglio LA, Mander AP, Dayan CM, Linsley PS, Herold KC, Marinac M, Ahmed ST. Diabetes Care. 2022 Dec 1. PMID: 36219765.", + "Innovative Designs and Logistical Considerations for Expedited Clinical Development of Combination Disease-Modifying Treatments for Type 1 Diabetes. Anderson RL, DiMeglio LA, Mander AP, Dayan CM, Linsley PS, Herold KC, Marinac M, Ahmed ST. Diabetes Care. 2022 Oct 1. PMID: 36150059.", + "The Transition From a Compensatory Increase to a Decrease in C-peptide During the Progression to Type 1 Diabetes and Its Relation to Risk. Ismail HM, Cuthbertson D, Gitelman SE, Skyler JS, Steck AK, Rodriguez H, Atkinson M, Nathan BM, Redondo MJ, Herold KC, Evans-Molina C, DiMeglio LA, Sosenko J. Diabetes Care. 2022 Oct 1. PMID: 35998266.", + "COVID-19 and children. Pierce CA, Herold KC, Herold BC, Chou J, Randolph A, Kane B, McFarland S, Gurdasani D, Pagel C, Hotez P, Cobey S, Hensley SE. Science. 2022 Sep 9; 2022 Sep 8. PMID: 36074833.", + "Immune cells and their inflammatory mediators modify β cells and cause checkpoint inhibitor-induced diabetes. Perdigoto AL, Deng S, Du KC, Kuchroo M, Burkhardt DB, Tong A, Israel G, Robert ME, Weisberg SP, Kirkiles-Smith N, Stamatouli AM, Kluger HM, Quandt Z, Young A, Yang ML, Mamula MJ, Pober JS, Anderson MS, Krishnaswamy S, Herold KC. JCI Insight. 2022 Sep 8; 2022 Sep 8. PMID: 35925682.", + "Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity. Yang ML, Connolly SE, Gee RJ, Lam TT, Kanyo J, Peng J, Guyer P, Syed F, Tse HM, Clarke SG, Clarke CF, James EA, Speake C, Evans-Molina C, Arvan P, Herold KC, Wen L, Mamula MJ. Diabetes. 2022 Sep 1. PMID: 35730902.", + "The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events? Mallone R, Halliez C, Rui J, Herold KC. Diabetes. 2022 Aug 1. PMID: 35881836.", + "Indirect and Direct Effects of SARS-CoV-2 on Human Pancreatic Islets. Ben Nasr M, D'Addio F, Montefusco L, Usuelli V, Loretelli C, Rossi A, Pastore I, Abdelsalam A, Maestroni A, Dell'Acqua M, Ippolito E, Assi E, Seelam AJ, Fiorina RM, Chebat E, Morpurgo P, Lunati ME, Bolla AM, Abdi R, Bonventre JV, Rusconi S, Riva A, Corradi D, Santus P, Clark P, Nebuloni M, Baldi G, Finzi G, Folli F, Zuccotti GV, Galli M, Herold KC, Fiorina P. Diabetes. 2022 Jul 1. PMID: 35499468.", + "Citrullination of glucokinase is linked to autoimmune diabetes. Yang ML, Horstman S, Gee R, Guyer P, Lam TT, Kanyo J, Perdigoto AL, Speake C, Greenbaum CJ, Callebaut A, Overbergh L, Kibbey RG, Herold KC, James EA, Mamula MJ. Nat Commun. 2022 Apr 6; 2022 Apr 6. PMID: 35388005.", + "Screening for Type 1 Diabetes in the General Population: A Status Report and Perspective. Sims EK, Besser REJ, Dayan C, Geno Rasmussen C, Greenbaum C, Griffin KJ, Hagopian W, Knip M, Long AE, Martin F, Mathieu C, Rewers M, Steck AK, Wentworth JM, Rich SS, Kordonouri O, Ziegler AG, Herold KC. Diabetes. 2022 Apr 1. PMID: 35316839.", + "Immune Checkpoint Inhibitor-Induced Hypophysitis and Patterns of Loss of Pituitary Function. Jessel S, Weiss SA, Austin M, Mahajan A, Etts K, Zhang L, Aizenbud L, Perdigoto AL, Hurwitz M, Sznol M, Herold KC, Kluger HM. Front Oncol. 2022; 2022 Mar 8. PMID: 35350573.", + "The Deterrence of Rapid Metabolic Decline Within 3 Months After Teplizumab Treatment in Individuals at High Risk for Type 1 Diabetes. Sims EK, Cuthbertson D, Herold KC, Sosenko JM. Diabetes. 2021 Dec; 2021 Sep 22. PMID: 34551936.", + "IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes. Greenbaum CJ, Serti E, Lambert K, Weiner LJ, Kanaparthi S, Lord S, Gitelman SE, Wilson DM, Gaglia JL, Griffin KJ, Russell WE, Raskin P, Moran A, Willi SM, Tsalikian E, DiMeglio LA, Herold KC, Moore WV, Goland R, Harris M, Craig ME, Schatz DA, Baidal DA, Rodriguez H, Utzschneider KM, Nel HJ, Soppe CL, Boyle KD, Cerosaletti K, Keyes-Elstein L, Long SA, Thomas R, McNamara JG, Buckner JH, Sanda S. JCI Insight. 2021 Nov 8; 2021 Nov 8. PMID: 34747368.", + "Advances in Type 1 Diabetes Prediction Using Islet Autoantibodies: Beyond a Simple Count. So M, Speake C, Steck AK, Lundgren M, Colman PG, Palmer JP, Herold KC, Greenbaum CJ. Endocr Rev. 2021 Sep 28. PMID: 33881515.", + "The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes. Dong S, Hiam-Galvez KJ, Mowery CT, Herold KC, Gitelman SE, Esensten JH, Liu W, Lares AP, Leinbach AS, Lee M, Nguyen V, Tamaki SJ, Tamaki W, Tamaki CM, Mehdizadeh M, Putnam AL, Spitzer MH, Ye CJ, Tang Q, Bluestone JA. JCI Insight. 2021 Sep 22; 2021 Sep 22. PMID: 34324441.", + "Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes. Rui J, Deng S, Perdigoto AL, Ponath G, Kursawe R, Lawlor N, Sumida T, Levine-Ritterman M, Stitzel ML, Pitt D, Lu J, Herold KC. Nat Commun. 2021 Aug 20; 2021 Aug 20. PMID: 34417463.", + "Immunotherapy: Building a bridge to a cure for type 1 diabetes. Bluestone JA, Buckner JH, Herold KC. Science. 2021 Jul 30; 2021 Jul 29. PMID: 34326232.", + "Natural mucosal barriers and COVID-19 in children. Pierce CA, Sy S, Galen B, Goldstein DY, Orner E, Keller MJ, Herold KC, Herold BC. JCI Insight. 2021 May 10; 2021 May 10. PMID: 33822777.", + "Quantifying the effect of experimental perturbations at single-cell resolution. Burkhardt DB, Stanley JS 3rd, Tong A, Perdigoto AL, Gigante SA, Herold KC, Wolf G, Giraldez AJ, van Dijk D, Krishnaswamy S. Nat Biotechnol. 2021 May; 2021 Feb 8. PMID: 33558698.", + "Adverse events induced by immune checkpoint inhibitors. Perdigoto AL, Kluger H, Herold KC. Curr Opin Immunol. 2021 Apr; 2021 Feb 25. PMID: 33640598.", + "Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals. Sims EK, Bundy BN, Stier K, Serti E, Lim N, Long SA, Geyer SM, Moran A, Greenbaum CJ, Evans-Molina C, Herold KC. Sci Transl Med. 2021 Mar 3. PMID: 33658358.", + "Natural Mucosal Barriers and COVID-19 in Children. Pierce CA, Sy S, Galen B, Goldstein DY, Orner E, Keller M, Herold KC, Herold B. medRxiv. 2021 Feb 13; 2021 Feb 13. PMID: 33594377.", + "A little help from residual β cells has long-lasting clinical benefits. Lam A, Dayan C, Herold KC. J Clin Invest. 2021 Feb 1. PMID: 33529163.", + "Autoimmune Endocrinopathies: An Emerging Complication of Immune Checkpoint Inhibitors. Quandt Z, Young A, Perdigoto AL, Herold KC, Anderson MS. Annu Rev Med. 2021 Jan 27; 2020 Sep 4. PMID: 32886542.", + "Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes. Jacobsen LM, Bundy BN, Greco MN, Schatz DA, Atkinson MA, Brusko TM, Mathews CE, Herold KC, Gitelman SE, Krischer JP, Haller MJ. Diabetes Technol Ther. 2020 Dec; 2020 Oct 20. PMID: 32833543.", + "Elective Colectomy in a Patient with Active Ulcerative Colitis and Metastatic Melanoma Enabling Successful Treatment with Immune Checkpoint Inhibitors. Perdigoto AL, Tran T, Patel N, Clark P, Patell K, Stamatouli AM, Reddy V, Clune J, Herold KC, Robert ME, Kluger HM. Clin Oncol Case Rep. 2020 Nov; 2020 Sep 17. PMID: 33778814.", + "Exenatide extended release in patients with type 1 diabetes with and without residual insulin production. Herold KC, Reynolds J, Dziura J, Baidal D, Gaglia J, Gitelman SE, Gottlieb PA, Marks J, Philipson LH, Pop-Busui R, Weinstock RS. Diabetes Obes Metab. 2020 Nov; 2020 Jul 29. PMID: 32573927.", + "Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients. Pierce CA, Preston-Hurlburt P, Dai Y, Aschner CB, Cheshenko N, Galen B, Garforth SJ, Herrera NG, Jangra RK, Morano NC, Orner E, Sy S, Chandran K, Dziura J, Almo SC, Ring A, Keller MJ, Herold KC, Herold BC. Sci Transl Med. 2020 Oct 7; 2020 Sep 21. PMID: 32958614.", + "The receptor for advanced glycation endproducts (RAGE) modulates T cell signaling. Reed JC, Preston-Hurlburt P, Philbrick W, Betancur G, Korah M, Lucas C, Herold KC. PLoS One. 2020; 2020 Sep 28. PMID: 32986722.", + "Slowed Metabolic Decline After 1 Year of Oral Insulin Treatment Among Individuals at High Risk for Type 1 Diabetes in the Diabetes Prevention Trial-Type 1 (DPT-1) and TrialNet Oral Insulin Prevention Trials. Sosenko JM, Skyler JS, Herold KC, Schatz DA, Haller MJ, Pugliese A, Cleves M, Geyer S, Rafkin LE, Matheson D, Palmer JP. Diabetes. 2020 Aug; 2020 May 21. PMID: 32439823.", + "Early and late C-peptide responses during oral glucose tolerance testing are oppositely predictive of type 1 diabetes in autoantibody-positive individuals. Ismail HM, Becker DJ, Libman I, Herold KC, Redondo MJ, Atkinson MA, Cleves MA, Palmer J, Sosenko J. Diabetes Obes Metab. 2020 Jun; 2020 Feb 27. PMID: 32003110.", + "PET Imaging of Pancreatic Dopamine D(2) and D(3) Receptor Density with (11)C-(+)-PHNO in Type 1 Diabetes. Bini J, Sanchez-Rangel E, Gallezot JD, Naganawa M, Nabulsi N, Lim K, Najafzadeh S, Shirali A, Ropchan J, Matuskey D, Huang Y, Herold KC, Harris PE, Sherwin RS, Carson RE, Cline GW. J Nucl Med. 2020 Apr; 2019 Oct 10. PMID: 31601695.", + "Circulating Unmethylated Insulin DNA As a Biomarker of Human Beta Cell Death: A Multi-laboratory Assay Comparison. Speake C, Ylescupidez A, Neiman D, Shemer R, Glaser B, Tersey SA, Usmani-Brown S, Clark P, Wilhelm JJ, Bellin MD, Herold KC, Mirmira RG, Dor Y, Evans-Molina C. J Clin Endocrinol Metab. 2020 Mar 1. PMID: 31913467.", + "Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes. Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ, Bosi E, Brusko TM, DiMeglio LA, Evans-Molina C, Gitelman SE, Greenbaum CJ, Gottlieb PA, Herold KC, Hessner MJ, Knip M, Jacobsen L, Krischer JP, Long SA, Lundgren M, McKinney EF, Morgan NG, Oram RA, Pastinen T, Peters MC, Petrelli A, Qian X, Redondo MJ, Roep BO, Schatz D, Skibinski D, Peakman M. Diabetes Care. 2020 Jan; 2019 Nov 21. PMID: 31753960.", + "Immunomodulatory activity of humanized anti-IL-7R monoclonal antibody RN168 in subjects with type 1 diabetes. Herold KC, Bucktrout SL, Wang X, Bode BW, Gitelman SE, Gottlieb PA, Hughes J, Joh T, McGill JB, Pettus JH, Potluri S, Schatz D, Shannon M, Udata C, Wong G, Levisetti M, Ganguly BJ, Garzone PD. JCI Insight. 2019 Dec 19; 2019 Dec 19. PMID: 31852846.", + "Islet Harvest in Carbon Monoxide-Saturated Medium for Chronic Pancreatitis Patients Undergoing Islet Autotransplantation. Wang H, Gou W, Strange C, Wang J, Nietert PJ, Cloud C, Owzarski S, Shuford B, Duke T, Luttrell L, Lesher A, Papas KK, Herold KC, Clark P, Usmani-Brown S, Kitzmann J, Crosson C, Adams DB, Morgan KA. Cell Transplant. 2019 Dec; 2019 Dec 30. PMID: 31885286.", + "Teplizumab in Relatives at Risk for Type 1 Diabetes. Reply. Herold KC, Bundy BN, Krischer JP. N Engl J Med. 2019 Nov 7. PMID: 31693818.", + "Changing the landscape for type 1 diabetes: the first step to prevention. Dayan CM, Korah M, Tatovic D, Bundy BN, Herold KC. Lancet. 2019 Oct 5; 2019 Sep 15. PMID: 31533907.", + "β cell responses to inflammation. Usmani-Brown S, Perdigoto AL, Lavoie N, Clark P, Korah M, Rui J, Betancur G, Herold KC. Mol Metab. 2019 Sep. PMID: 31500821.", + "An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes. Herold KC, Bundy BN, Long SA, Bluestone JA, DiMeglio LA, Dufort MJ, Gitelman SE, Gottlieb PA, Krischer JP, Linsley PS, Marks JB, Moore W, Moran A, Rodriguez H, Russell WE, Schatz D, Skyler JS, Tsalikian E, Wherrett DK, Ziegler AG, Greenbaum CJ. N Engl J Med. 2019 Aug 15; 2019 Jun 9. PMID: 31180194.", + "Unmethylated Insulin as an Adjunctive Marker of Beta Cell Death and Progression to Type 1 Diabetes in Participants at Risk for Diabetes. Simmons KM, Fouts A, Pyle L, Clark P, Dong F, Yu L, Usmani-Brown S, Gottlieb P, Herold KC, Steck AK. Int J Mol Sci. 2019 Aug 8; 2019 Aug 8. PMID: 31398795.", + "Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances. Ahmed S, Cerosaletti K, James E, Long SA, Mannering S, Speake C, Nakayama M, Tree T, Roep BO, Herold KC, Brusko TM. Diabetes. 2019 Jul. PMID: 31221801.", + "Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA(1c), and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data. Haller MJ, Long SA, Blanchfield JL, Schatz DA, Skyler JS, Krischer JP, Bundy BN, Geyer SM, Warnock MV, Miller JL, Atkinson MA, Becker DJ, Baidal DA, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Herold KC, Marks JB, Moran A, Rodriguez H, Russell WE, Wilson DM, Greenbaum CJ. Diabetes. 2019 Jun; 2019 Apr 9. PMID: 30967424.", + "Associations of HbA1c with the timing of C-peptide responses during the oral glucose tolerance test at the diagnosis of type 1 diabetes. Ismail HM, Evans-Molina C, DiMeglio LA, Becker DJ, Libman I, Sims EK, Boulware D, Herold KC, Rafkin L, Skyler J, Cleves MA, Palmer J, Sosenko JM. Pediatr Diabetes. 2019 Jun; 2019 Apr 15. PMID: 30891858.", + "Checkpoint inhibitor-induced insulin-dependent diabetes: an emerging syndrome. Perdigoto AL, Quandt Z, Anderson M, Herold KC. Lancet Diabetes Endocrinol. 2019 Jun; 2019 Mar 15. PMID: 30885563.", + "Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosis. Perdigoto AL, Preston-Hurlburt P, Clark P, Long SA, Linsley PS, Harris KM, Gitelman SE, Greenbaum CJ, Gottlieb PA, Hagopian W, Woodwyk A, Dziura J, Herold KC. Diabetologia. 2019 Apr; 2018 Dec 19. PMID: 30569273.", + "Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes. Linsley PS, Greenbaum CJ, Rosasco M, Presnell S, Herold KC, Dufort MJ. Genes Immun. 2019 Apr; 2018 Jun 21. PMID: 29925930.", + "A Call for Improved Reporting of Human Islet Characteristics in Research Articles. Poitout V, Satin LS, Kahn SE, Stoffers DA, Marchetti P, Gannon M, Verchere CB, Herold KC, Myers MG Jr, Marshall SM. Diabetes. 2019 Feb; 2018 Dec 14. PMID: 30552106.", + "A call for improved reporting of human islet characteristics in research articles. Poitout V, Satin LS, Kahn SE, Stoffers DA, Marchetti P, Gannon M, Verchere CB, Herold KC, Myers MG Jr, Marshall SM. Diabetologia. 2019 Feb; 2018 Dec 14. PMID: 30547229.", + "Increased Reporting of Immune Checkpoint Inhibitor-Associated Diabetes. Wright JJ, Salem JE, Johnson DB, Lebrun-Vignes B, Stamatouli A, Thomas JW, Herold KC, Moslehi J, Powers AC. Diabetes Care. 2018 Dec; 2018 Oct 10. PMID: 30305348.", + "Oxidative Modifications in Tissue Pathology and Autoimmune Disease. Yang ML, Doyle HA, Clarke SG, Herold KC, Mamula MJ. Antioxid Redox Signal. 2018 Nov 10; 2017 Dec 11. PMID: 29088923.", + "Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [(18)F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes. Naganawa M, Lim K, Nabulsi NB, Lin SF, Labaree D, Ropchan J, Herold KC, Huang Y, Harris P, Ichise M, Cline GW, Carson RE. Mol Imaging Biol. 2018 Oct. PMID: 29468404.", + "Dana Clinic Building 789 Howard Avenue New Haven, CT 06510", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Herzog Lab", + "lab_url": "https://medicine.yale.edu/lab/herzog/", + "research_bio": "INFORMATION FOR The Herzog lab’s mission is to perform high quality translational studies aimed at elucidating common mechanism(s) of multiple forms of pulmonary fibrosis. These studies employ a unique combination of murine modeling and novel bioengineering-based approaches, as well as studies in primary human cells, that are aimed at unveiling the immunopathogenesis of human lung fibrosis. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/herzog/publications", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Pulmonary, Critical Care & Sleep Medicine /", + "Research", + "Contact Us", + "Publications", + "Lab Members", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Publications", + "Lab Members", + "News", + "Contact Us", + "", + "", + "", + "", + "", + "", + "The Anlyan Center for Medical Research & Education 300 Cedar Street New Haven, CT 06510", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Hochstrasser Lab", + "lab_url": "https://medicine.yale.edu/lab/hochstrasser/", + "research_bio": "INFORMATION FOR Work in our lab resides at the crossroads of biochemistry and genetics and takes advantage of the many research benefits offered by the yeastSaccharomyces cerevisiaeas a model eukaryotic cell system. A short, but by no means exhaustive, list of areas of active study can be foundhere. For most short-lived eukaryotic proteins, attachment to ubiquitin is an obligatory step in the cascade of events that culminates in their degradation. Protein turnover via the highly conserved ubiquitin-proteasome system is central to a great variety of regulatory mechanisms, including many of medical relevance. We wish to understand, at a mechanistic and molecular level, how specific proteins are rapidly degraded within cells even while most proteins are spared. This entails detailed functional analysis of the various elements of the ubiquitin-proteasome system, from the degradation signals targeting proteins for destruction, to the components of the ubiquitin conjugation machinery, to the proteasome itself. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/hochstrasser/publications/", + "publications": [ + "Yale School of Medicine /", + "Molecular Biophysics and Biochemistry /", + "Research", + "Contact", + "People Former Members", + "Former Members", + "Links", + "Publications", + "Photos", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "Photos", + "Contact", + "Links", + "", + "", + "", + "", + "", + "", + "AMPK alters proteasome phosphorylation status and prevents persistent proteasome condensates. Li J, Butcher C, VanderVen K, Fitz-Enz M, Hochstrasser M. Genetics. 2025 Nov 12. PMID: 40880204.", + "Deubiquitylases and nucleases in bacterial symbiont-induced cytoplasmic incompatibility. Oladipupo SO, Hochstrasser M. Biochem Soc Trans. 2025 Oct 29. PMID: 41124367.", + "Use of a High-Affinity Ubiquitin-Binding Domain to Detect and Purify Ubiquitinated Substrates and Their Interacting Proteins. Saha N, Zhang M, Hochstrasser M. Bio Protoc. 2025 Sep 5; 2025 Sep 5. PMID: 40948893.", + "AMPK alters proteasome phosphorylation status and prevents persistent proteasome condensates. Li J, Butcher C, VanderVen K, Hochstrasser M. bioRxiv. 2025 Jul 2; 2025 Jul 2. PMID: 40631302.", + "Auto-sumoylation of the yeast Ubc9 E2 SUMO-conjugating enzyme extends cellular lifespan. Jeong DW, Lee DY, Kim SY, Jeoung SW, Zhao D, Knight J, Lam TT, Jin JH, Lee HS, Hochstrasser M, Ryu HY. Nat Commun. 2025 Apr 20; 2025 Apr 20. PMID: 40254622.", + "A cut above: Bacterial deubiquitinases with ubiquitin clippase activity. Hochstrasser M. Mol Cell. 2025 Mar 20. PMID: 40118036.", + "Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity. Ruiz-Romero G, Berdún MD, Hochstrasser M, Salas-Pino S, Daga RR. iScience. 2024 Nov 15; 2024 Oct 4. PMID: 39473973.", + "Auto-sumoylation of the Ubc9 E2 SUMO-conjugating Enzyme Extends Cellular Lifespan. Ryu HY, Jeong DW, Kim SY, Jeoung SW, Zhao D, Knight J, Lam T, Jin JH, Lee HS, Hochstrasser M. Res Sq. 2024 Mar 21; 2024 Mar 21. PMID: 38562857.", + "Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1. Breckel CA, Johnson ZM, Hickey CM, Hochstrasser M. Sci Rep. 2024 Jan 24; 2024 Jan 24. PMID: 38267508.", + "Sis2 regulates yeast replicative lifespan in a dose-dependent manner. Ölmez TT, Moreno DF, Liu P, Johnson ZM, McGinnis MM, Tu BP, Hochstrasser M, Acar M. Nat Commun. 2023 Nov 27; 2023 Nov 27. PMID: 38012152.", + "Molecular Biology of Cytoplasmic Incompatibility Caused by Wolbachia Endosymbionts. Hochstrasser M. Annu Rev Microbiol. 2023 Sep 15; 2023 Jun 7. PMID: 37285552.", + "Species-specific protein-protein interactions govern the humanization of the 20S proteasome in yeast. Sultana S, Abdullah M, Li J, Hochstrasser M, Kachroo AH. Genetics. 2023 Aug 31. PMID: 37364278.", + "Proteasomes: Isolation and Activity Assays. Li Y, Tomko RJ Jr, Hochstrasser M. Curr Protoc. 2023 Apr. PMID: 37026813.", + "Ectopic RING activity at the ER membrane differentially impacts ERAD protein quality control pathways. Mehrtash AB, Hochstrasser M. J Biol Chem. 2023 Mar; 2023 Jan 19. PMID: 36682496.", + "Orientia tsutsugamushi OtDUB Is Expressed and Interacts with Adaptor Protein Complexes during Infection. Adcox HE, Berk JM, Hochstrasser M, Carlyon JA. Infect Immun. 2022 Dec 15; 2022 Nov 14. PMID: 36374099.", + "Elements of the ERAD ubiquitin ligase Doa10 regulating sequential poly-ubiquitylation of its targets. Mehrtash AB, Hochstrasser M. iScience. 2022 Nov 18; 2022 Oct 13. PMID: 36325070.", + "OtDUB from the Human Pathogen Orientia tsutsugamushi Modulates Host Membrane Trafficking by Multiple Mechanisms. Berk JM, Lee MJ, Zhang M, Lim C, Hochstrasser M. Mol Cell Biol. 2022 Jul 21; 2022 Jun 21. PMID: 35727026.", + "A versatile new tool derived from a bacterial deubiquitylase to detect and purify ubiquitylated substrates and their interacting proteins. Zhang M, Berk JM, Mehrtash AB, Kanyo J, Hochstrasser M. PLoS Biol. 2022 Jun; 2022 Jun 30. PMID: 35771886.", + "Cytoplasmic incompatibility: A Wolbachia toxin-antidote mechanism comes into view. Hochstrasser M. Curr Biol. 2022 Mar 28. PMID: 35349818.", + "Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue. Wang H, Xiao Y, Chen X, Zhang M, Sun G, Wang F, Wang L, Zhang H, Zhang X, Yang X, Li W, Wei Y, Yao D, Zhang B, Li J, Cui W, Wang F, Chen C, Shen W, Su D, Bai F, Huang J, Ye S, Zhang L, Ji X, Wang W, Wang Z, Hochstrasser M, Yang H. Nat Commun. 2022 Mar 25; 2022 Mar 25. PMID: 35338130.", + "The CinB Nuclease from wNo Wolbachia Is Sufficient for Induction of Cytoplasmic Incompatibility in Drosophila. Sun G, Zhang M, Chen H, Hochstrasser M. mBio. 2022 Feb 22; 2022 Jan 25. PMID: 35073749.", + "Selective microautophagy of proteasomes is initiated by ESCRT-0 and is promoted by proteasome ubiquitylation. Li J, Hochstrasser M. J Cell Sci. 2022 Feb 15; 2022 Feb 21. PMID: 35099016.", + "Ubiquitin Ligase Redundancy and Nuclear-Cytoplasmic Localization in Yeast Protein Quality Control. Breckel CA, Hochstrasser M. Biomolecules. 2021 Dec 3; 2021 Dec 3. PMID: 34944465.", + "Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors. Xiao Y, Chen H, Wang H, Zhang M, Chen X, Berk JM, Zhang L, Wei Y, Li W, Cui W, Wang F, Wang Q, Cui C, Li T, Chen C, Ye S, Zhang L, Ji X, Huang J, Wang W, Wang Z, Hochstrasser M, Yang H. Proc Natl Acad Sci U S A. 2021 Oct 12. PMID: 34620712.", + "Yeast Nst1 is a novel component of P-bodies and is a specific suppressor of proteasome base assembly defects. Cheng CL, Wong MK, Hochstrasser M. Mol Biol Cell. 2021 Oct 1; 2021 Aug 4. PMID: 34347506.", + "Histone sumoylation and chromatin dynamics. Ryu HY, Hochstrasser M. Nucleic Acids Res. 2021 Jun 21. PMID: 33885816.", + "Protein quality control degron-containing substrates are differentially targeted in the cytoplasm and nucleus by ubiquitin ligases. Hickey CM, Breckel C, Zhang M, Theune WC, Hochstrasser M. Genetics. 2021 Mar 3. PMID: 33683364.", + "Conserved proline residues in the coiled coil-OB domain linkers of Rpt proteins facilitate eukaryotic proteasome base assembly. Cheng CL, Wong MK, Li Y, Hochstrasser M. J Biol Chem. 2021 Jan-Jun; 2021 Apr 14. PMID: 33862083.", + "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). 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PMID: 27404243.", + "A Conserved C-terminal Element in the Yeast Doa10 and Human MARCH6 Ubiquitin Ligases Required for Selective Substrate Degradation. Zattas D, Berk JM, Kreft SG, Hochstrasser M. J Biol Chem. 2016 Jun 3; 2016 Apr 11. PMID: 27068744.", + "Recent progress in ubiquitin and ubiquitin-like protein (Ubl) signaling. Hu R, Hochstrasser M. Cell Res. 2016 Apr. PMID: 27033807.", + "Substrate specificity of the ubiquitin and Ubl proteases. Ronau JA, Beckmann JF, Hochstrasser M. Cell Res. 2016 Apr; 2016 Mar 25. PMID: 27012468.", + "SUMO Pathway Modulation of Regulatory Protein Binding at the Ribosomal DNA Locus in Saccharomyces cerevisiae. Gillies J, Hickey CM, Su D, Wu Z, Peng J, Hochstrasser M. Genetics. 2016 Apr; 2016 Feb 2. PMID: 26837752.", + "Assembly of an Evolutionarily Conserved Alternative Proteasome Isoform in Human Cells. Padmanabhan A, Vuong SA, Hochstrasser M. Cell Rep. 2016 Mar 29; 2016 Mar 22. PMID: 26997268.", + "A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome. Huber EM, Heinemeyer W, Li X, Arendt CS, Hochstrasser M, Groll M. Nat Commun. 2016 Mar 11; 2016 Mar 11. PMID: 26964885.", + "Distinct Elements in the Proteasomal β5 Subunit Propeptide Required for Autocatalytic Processing and Proteasome Assembly. Li X, Li Y, Arendt CS, Hochstrasser M. J Biol Chem. 2016 Jan 22; 2015 Dec 1. PMID: 26627836.", + "The Regulation of Chromatin by Dynamic SUMO Modifications. Wilson NR, Hochstrasser M. Methods Mol Biol. 2016. PMID: 27631795.", + "A Single α Helix Drives Extensive Remodeling of the Proteasome Lid and Completion of Regulatory Particle Assembly. Tomko RJ Jr, Taylor DW, Chen ZA, Wang HW, Rappsilber J, Hochstrasser M. Cell. 2015 Oct 8. PMID: 26451487.", + "STUbL-mediated degradation of the transcription factor MATα2 requires degradation elements that coincide with corepressor binding sites. Hickey CM, Hochstrasser M. Mol Biol Cell. 2015 Oct 1; 2015 Aug 5. PMID: 26246605.", + "Proteasomes: Isolation and Activity Assays. Li Y, Tomko RJ Jr, Hochstrasser M. Curr Protoc Cell Biol. 2015 Jun 1; 2015 Jun 1. PMID: 26061243.", + "Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope. Zattas D, Hochstrasser M. Crit Rev Biochem Mol Biol. 2015 Jan-Feb; 2014 Sep 18. PMID: 25231236.", + "Site-specific cation release drives actin filament severing by vertebrate cofilin. Kang H, Bradley MJ, Cao W, Zhou K, Grintsevich EE, Michelot A, Sindelar CV, Hochstrasser M, De La Cruz EM. Proc Natl Acad Sci U S A. 2014 Dec 16; 2014 Dec 2. PMID: 25468977.", + "The intrinsically disordered Sem1 protein functions as a molecular tether during proteasome lid biogenesis. Tomko RJ Jr, Hochstrasser M. Mol Cell. 2014 Feb 6; 2014 Jan 9. PMID: 24412063.", + "Assembly of the 20S proteasome. Kunjappu MJ, Hochstrasser M. Biochim Biophys Acta. 2014 Jan; 2013 Mar 16. PMID: 23507199.", + "A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway. Sá-Moura B, Funakoshi M, Tomko RJ Jr, Dohmen RJ, Wu Z, Peng J, Hochstrasser M. J Biol Chem. 2013 Nov 22; 2013 Oct 11. PMID: 24121501.", + "N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates. Zattas D, Adle DJ, Rubenstein EM, Hochstrasser M. Mol Biol Cell. 2013 Apr; 2013 Jan 30. PMID: 23363603.", + "Molecular architecture and assembly of the eukaryotic proteasome. Tomko RJ Jr, Hochstrasser M. Annu Rev Biochem. 2013; 2013 Mar 13. PMID: 23495936.", + "Function and regulation of SUMO proteases. Hickey CM, Wilson NR, Hochstrasser M. Nat Rev Mol Cell Biol. 2012 Dec. PMID: 23175280.", + "Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase. Rubenstein EM, Kreft SG, Greenblatt W, Swanson R, Hochstrasser M. J Cell Biol. 2012 Jun 11. PMID: 22689655.", + "A new class of SUMO proteases. Gillies J, Hochstrasser M. EMBO Rep. 2012 Apr 2; 2012 Apr 2. PMID: 22422001.", + "Disulfide engineering to map subunit interactions in the proteasome and other macromolecular complexes. Hochstrasser M, Funakoshi M. Methods Mol Biol. 2012. PMID: 22350897.", + "Desumoylation of the endoplasmic reticulum membrane VAP family protein Scs2 by Ulp1 and SUMO regulation of the inositol synthesis pathway. Felberbaum R, Wilson NR, Cheng D, Peng J, Hochstrasser M. Mol Cell Biol. 2012 Jan; 2011 Oct 24. PMID: 22025676.", + "Incorporation of the Rpn12 subunit couples completion of proteasome regulatory particle lid assembly to lid-base joining. Tomko RJ Jr, Hochstrasser M. Mol Cell. 2011 Dec 23. PMID: 22195964.", + "Analysis of protein ubiquitination. Laney JD, Hochstrasser M. Curr Protoc Protein Sci. 2011 Nov. PMID: 22045559.", + "An unusual transmembrane helix in the endoplasmic reticulum ubiquitin ligase Doa10 modulates degradation of its cognate E2 enzyme. Kreft SG, Hochstrasser M. J Biol Chem. 2011 Jun 10; 2011 Apr 5. PMID: 21467040.", + "Order of the proteasomal ATPases and eukaryotic proteasome assembly. Tomko RJ Jr, Hochstrasser M. Cell Biochem Biophys. 2011 Jun. PMID: 21461838.", + "A conserved 20S proteasome assembly factor requires a C-terminal HbYX motif for proteasomal precursor binding. Kusmierczyk AR, Kunjappu MJ, Kim RY, Hochstrasser M. Nat Struct Mol Biol. 2011 May; 2011 Apr 17. PMID: 21499243.", + "Redundancy and variation in the ubiquitin-mediated proteolytic targeting of a transcription factor. Rubenstein EM, Hochstrasser M. Cell Cycle. 2010 Nov 1; 2010 Nov 22. PMID: 20980825.", + "A WLM protein with SUMO-directed protease activity. Su D, Hochstrasser M. Mol Cell Biol. 2010 Aug; 2010 Jun 21. PMID: 20566698.", + "Heterohexameric ring arrangement of the eukaryotic proteasomal ATPases: implications for proteasome structure and assembly. Tomko RJ Jr, Funakoshi M, Schneider K, Wang J, Hochstrasser M. Mol Cell. 2010 May 14. PMID: 20471945.", + "SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor. Xie Y, Rubenstein EM, Matt T, Hochstrasser M. Genes Dev. 2010 May; 2010 Apr 13. PMID: 20388728.", + "Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base. Funakoshi M, Tomko RJ Jr, Kobayashi H, Hochstrasser M. Cell. 2009 May 29; 2009 May 14. PMID: 19446322.", + "Essential role of nuclear localization for yeast Ulp2 SUMO protease function. Kroetz MB, Su D, Hochstrasser M. Mol Biol Cell. 2009 Apr; 2009 Feb 18. PMID: 19225149.", + "Origin and function of ubiquitin-like proteins. Hochstrasser M. Nature. 2009 Mar 26. PMID: 19325621.", + "Small epitope-linker modules for PCR-based C-terminal tagging in Saccharomyces cerevisiae. Funakoshi M, Hochstrasser M. Yeast. 2009 Mar. PMID: 19243080.", + "Identification of SUMO-interacting proteins by yeast two-hybrid analysis. Kroetz MB, Hochstrasser M. Methods Mol Biol. 2009. PMID: 19107413.", + "Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II. Wang L, Dong H, Soroka CJ, Wei N, Boyer JL, Hochstrasser M. Hepatology. 2008 Nov. PMID: 18798335.", + "Some assembly required: dedicated chaperones in eukaryotic proteasome biogenesis. Kusmierczyk AR, Hochstrasser M. Biol Chem. 2008 Sep. PMID: 18713001.", + "A multimeric assembly factor controls the formation of alternative 20S proteasomes. Kusmierczyk AR, Kunjappu MJ, Funakoshi M, Hochstrasser M. Nat Struct Mol Biol. 2008 Mar; 2008 Feb 17. PMID: 18278055.", + "Ulp2 and the DNA damage response: desumoylation enables safe passage through mitosis. Felberbaum R, Hochstrasser M. Cell Cycle. 2008 Jan 1; 2007 Oct 28. PMID: 18196960.", + "The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation. Xie Y, Kerscher O, Kroetz MB, McConchie HF, Sung P, Hochstrasser M. J Biol Chem. 2007 Nov 23; 2007 Sep 11. PMID: 17848550.", + "Orientia tsutsugamushi OtDUB Is Expressed and Interacts with Adaptor Protein Complexes during Infection. Adcox HE, Berk JM, Hochstrasser M, Carlyon JA. Infect Immun. 2022 Dec 15; 2022 Nov 14. PMID: 36374099.", + "OtDUB from the Human Pathogen Orientia tsutsugamushi Modulates Host Membrane Trafficking by Multiple Mechanisms. Berk JM, Lee MJ, Zhang M, Lim C, Hochstrasser M. Mol Cell Biol. 2022 Jul 21; 2022 Jun 21. PMID: 35727026.", + "A versatile new tool derived from a bacterial deubiquitylase to detect and purify ubiquitylated substrates and their interacting proteins. Zhang M, Berk JM, Mehrtash AB, Kanyo J, Hochstrasser M. PLoS Biol. 2022 Jun; 2022 Jun 30. PMID: 35771886.", + "Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors. Xiao Y, Chen H, Wang H, Zhang M, Chen X, Berk JM, Zhang L, Wei Y, Li W, Cui W, Wang F, Wang Q, Cui C, Li T, Chen C, Ye S, Zhang L, Ji X, Huang J, Wang W, Wang Z, Hochstrasser M, Yang H. Proc Natl Acad Sci U S A. 2021 Oct 12. PMID: 34620712.", + "Crystal structure of a guanine nucleotide exchange factor encoded by the scrub typhus pathogen Orientia tsutsugamushi. Lim C, Berk JM, Blaise A, Bircher J, Koleske AJ, Hochstrasser M, Xiong Y. Proc Natl Acad Sci U S A. 2020 Dec 1; 2020 Nov 12. PMID: 33184172.", + "A deubiquitylase with an unusually high-affinity ubiquitin-binding domain from the scrub typhus pathogen Orientia tsutsugamushi. Berk JM, Lim C, Ronau JA, Chaudhuri A, Chen H, Beckmann JF, Loria JP, Xiong Y, Hochstrasser M. Nat Commun. 2020 May 11; 2020 May 11. PMID: 32393759.", + "Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation. Sharpe LJ, Howe V, Scott NA, Luu W, Phan L, Berk JM, Hochstrasser M, Brown AJ. J Biol Chem. 2019 Feb 15; 2018 Dec 13. PMID: 30545937.", + "Protein Modification: Bacterial Effectors Rewrite the Rules of Ubiquitylation. Berk JM, Hochstrasser M. Curr Biol. 2016 Jul 11. PMID: 27404243.", + "A Conserved C-terminal Element in the Yeast Doa10 and Human MARCH6 Ubiquitin Ligases Required for Selective Substrate Degradation. Zattas D, Berk JM, Kreft SG, Hochstrasser M. J Biol Chem. 2016 Jun 3; 2016 Apr 11. PMID: 27068744.", + "Simple Separation of Functionally Distinct Populations of Lamin-Binding Proteins. Berk JM, Wilson KL. Methods Enzymol. 2016; 2015 Oct 27. PMID: 26778555.", + "The molecular basis of emerin-emerin and emerin-BAF interactions. Berk JM, Simon DN, Jenkins-Houk CR, Westerbeck JW, Grønning-Wang LM, Carlson CR, Wilson KL. J Cell Sci. 2014 Sep 15; 2014 Jul 22. PMID: 25052089.", + "O-Linked β-N-acetylglucosamine (O-GlcNAc) regulates emerin binding to barrier to autointegration factor (BAF) in a chromatin- and lamin B-enriched \"niche\". Berk JM, Maitra S, Dawdy AW, Shabanowitz J, Hunt DF, Wilson KL. J Biol Chem. 2013 Oct 18; 2013 Sep 6. PMID: 24014020.", + "The nuclear envelope LEM-domain protein emerin. Berk JM, Tifft KE, Wilson KL. Nucleus. 2013 Jul-Aug; 2013 Jul 17. PMID: 23873439.", + "The nuclear envelope at a glance. Wilson KL, Berk JM. J Cell Sci. 2010 Jun 15. PMID: 20519579.", + "Mitosis-specific mechanosensing and contractile-protein redistribution control cell shape. Effler JC, Kee YS, Berk JM, Tran MN, Iglesias PA, Robinson DN. Curr Biol. 2006 Oct 10. PMID: 17027494.", + "Corrigendum to \"In vivo analyses of embryotoxicity and teratogenicity of gold nanoparticles: Emphasis on the surface chemistry and toxicological responses\" [Ecotoxicol. Environ. Saf. 304 (2025) 119111]. Ismail T, Jeong YG, Lee HK, Lee H, Kim Y, Lee JY, Kim SH, Ryu HY, Kwon TK, Park TJ, Kwon T, Khang D, Lee HS. Ecotoxicol Environ Saf. 2025 Oct 31; 2025 Oct 31. PMID: 41176446.", + "Mtx2 requirement for craniofacial morphogenesis with implications for mandibuloacral dysplasia. Yang B, Lee HK, Lee H, Ryu HY, Kim HT, Lee HS. Biochem Biophys Res Commun. 2025 Oct 10; 2025 Sep 15. PMID: 40967033.", + "In vivo analyses of embryotoxicity and teratogenicity of gold nanoparticles: Emphasis on the surface chemistry and toxicological responses. Ismail T, Jeong YG, Lee HK, Lee H, Kim Y, Lee JY, Kim SH, Ryu HY, Kwon TK, Park TJ, Kwon T, Khang D, Lee HS. Ecotoxicol Environ Saf. 2025 Oct 1; 2025 Sep 28. PMID: 41016142.", + "Epigenetic regulation of intracellular branched-chain amino acid homeostasis maintains a normal lifespan. Park S, Liu Y, Lim S, Ryu HY, Ahn SH. iScience. 2025 Jul 18; 2025 Jun 7. PMID: 40655096.", + "Auto-sumoylation of the yeast Ubc9 E2 SUMO-conjugating enzyme extends cellular lifespan. Jeong DW, Lee DY, Kim SY, Jeoung SW, Zhao D, Knight J, Lam TT, Jin JH, Lee HS, Hochstrasser M, Ryu HY. Nat Commun. 2025 Apr 20; 2025 Apr 20. PMID: 40254622.", + "HSD17B4 deficiency causes dysregulation of primary cilia and is alleviated by acetyl-CoA. Bae JE, Jang S, Kim JB, Park NY, Jo DS, Hyung H, Kim P, Kim MS, Ryu HY, Lee HS, Lee DS, Baes M, Ryoo ZY, Cho DH. Nat Commun. 2025 Mar 18; 2025 Mar 18. PMID: 40102401.", + "Histone H3 lysine 9 tri-methylation is associated with pterygium. Choi D, Na AY, Jeoung SW, Choi YH, Park N, Park HS, Kwon HK, Lee HS, Cho DH, Kim DH, Ryu HY. BMC Ophthalmol. 2025 Mar 3; 2025 Mar 3. PMID: 40033254.", + "Rare disease genomics and precision medicine. Hong J, Lee D, Hwang A, Kim T, Ryu HY, Choi J. Genomics Inform. 2024 Dec 3; 2024 Dec 3. PMID: 39627904.", + "Histone Modification Pathways Suppressing Cryptic Transcription. Ryu HY. Epigenomes. 2024 Nov 12; 2024 Nov 12. PMID: 39584965.", + "Increased ER stress by depletion of PDIA6 impairs primary ciliogenesis and enhances sensitivity to ferroptosis in kidney cells. Kim JB, Hyung H, Bae JE, Jang S, Park NY, Jo DS, Kim YH, Choi DK, Ryu HY, Lee HS, Ryoo ZY, Cho DH. BMB Rep. 2024 Oct. PMID: 39044457.", + "Tho2-mediated escort of Nrd1 regulates the expression of aging-related genes. Liu Y, Park JM, Lim S, Duan R, Lee DY, Choi D, Choi DK, Rhie BH, Cho SY, Ryu HY, Ahn SH. Aging Cell. 2024 Aug; 2024 May 20. PMID: 38769776.", + "Yeast Small Ubiquitin-Like Modifier (SUMO) Protease Ulp2 is Involved in RNA Splicing. Park JM, Choi S, Choi DK, Lee HS, Cho DH, Choi J, Ryu HY. Dev Reprod. 2024 Jun; 2024 Jun 30. PMID: 39055101.", + "Actin depolymerizing factor destrin governs cell migration in neural development during Xenopus embryogenesis. Kim Y, Lee HK, Park KY, Ismail T, Lee H, Ryu HY, Cho DH, Kwon TK, Park TJ, Kwon T, Lee HS. Mol Cells. 2024 Jun; 2024 May 31. PMID: 38825188.", + "Auto-sumoylation of the Ubc9 E2 SUMO-conjugating Enzyme Extends Cellular Lifespan. Ryu HY, Jeong DW, Kim SY, Jeoung SW, Zhao D, Knight J, Lam T, Jin JH, Lee HS, Hochstrasser M. Res Sq. 2024 Mar 21; 2024 Mar 21. PMID: 38562857.", + "Early life exposure to perfluorooctanesulfonate (PFOS) impacts vital biological processes in Xenopus laevis: Integrated morphometric and transcriptomic analyses. Ismail T, Lee HK, Lee H, Kim Y, Kim E, Lee JY, Kim KB, Ryu HY, Cho DH, Kwon TK, Park TJ, Kwon T, Lee HS. Ecotoxicol Environ Saf. 2024 Jan 1; 2023 Dec 15. PMID: 38103469.", + "Histone modification in Saccharomyces cerevisiae: A review of the current status. Chou KY, Lee JY, Kim KB, Kim E, Lee HS, Ryu HY. Comput Struct Biotechnol J. 2023; 2023 Feb 24. PMID: 36915383.", + "PCNB exposure during early embryogenic development induces developmental delay and teratogenicity by altering the gene expression in Xenopus laevis. Ismail T, Lee H, Kim Y, Ryu HY, Cho DH, Ryoo ZY, Lee DS, Kwon TK, Park TJ, Kwon T, Lee HS. Environ Toxicol. 2023 Jan; 2022 Oct 11. PMID: 36218123.", + "SUMO pathway is required for ribosome biogenesis. Ryu HY. BMB Rep. 2022 Nov. PMID: 36195568.", + "Carnitine Protects against MPP(+)-Induced Neurotoxicity and Inflammation by Promoting Primary Ciliogenesis in SH-SY5Y Cells. Bae JE, Kim JB, Jo DS, Park NY, Kim YH, Lee HJ, Kim SH, Kim SH, Son M, Kim P, Ryu HY, Lee WH, Ryoo ZY, Lee HS, Jung YK, Cho DH. Cells. 2022 Sep 1; 2022 Sep 1. PMID: 36078130.", + "SUMOylation and Major Depressive Disorder. Jeoung SW, Park HS, Ryoo ZY, Cho DH, Lee HS, Ryu HY. Int J Mol Sci. 2022 Jul 21; 2022 Jul 21. PMID: 35887370.", + "Sus1 maintains a normal lifespan through regulation of TREX-2 complex-mediated mRNA export. Lim S, Liu Y, Rhie BH, Kim C, Ryu HY, Ahn SH. Aging (Albany NY). 2022 Jun 29; 2022 Jun 29. PMID: 35771153.", + "Nuclear mRNA Export and Aging. Park HS, Lee J, Lee HS, Ahn SH, Ryu HY. Int J Mol Sci. 2022 May 13; 2022 May 13. PMID: 35628261.", + "Trans-tail regulation-mediated suppression of cryptic transcription. Choi J, Ryoo ZY, Cho DH, Lee HS, Ryu HY. Exp Mol Med. 2021 Nov; 2021 Nov 29. PMID: 34845331.", + "Physiological Functions of Thiol Peroxidases (Gpx1 and Prdx2) during Xenopus laevis Embryonic Development. Lee H, Lee NY, Kim Y, Choi HS, Ismail T, Ryu HY, Cho DH, Ryoo ZY, Lee DS, Kwon TK, Park TJ, Kwon T, Lee HS. Antioxidants (Basel). 2021 Oct 17; 2021 Oct 17. PMID: 34679770.", + "2-IPMA Ameliorates PM2.5-Induced Inflammation by Promoting Primary Ciliogenesis in RPE Cells. Choi JY, Bae JE, Kim JB, Jo DS, Park NY, Kim YH, Lee HJ, Kim SH, Kim SH, Jeon HB, Na HW, Choi H, Ryu HY, Ryoo ZY, Lee HS, Cho DH. Molecules. 2021 Sep 6; 2021 Sep 6. PMID: 34500843.", + "SUMO: a novel target for anti-coronavirus therapy. Ryu HY. Pathog Glob Health. 2021 Jul; 2021 Mar 26. PMID: 33769223.", + "Histone sumoylation and chromatin dynamics. Ryu HY, Hochstrasser M. Nucleic Acids Res. 2021 Jun 21. PMID: 33885816.", + "The Spt7 subunit of the SAGA complex is required for the regulation of lifespan in both dividing and nondividing yeast cells. Lim S, Ahn H, Duan R, Liu Y, Ryu HY, Ahn SH. Mech Ageing Dev. 2021 Jun; 2021 Apr 5. PMID: 33831401.", + "Epigenetic Targeting of Histone Deacetylases in Diagnostics and Treatment of Depression. Park HS, Kim J, Ahn SH, Ryu HY. Int J Mol Sci. 2021 May 20; 2021 May 20. PMID: 34065586.", + "MicroRNA 34a-AXL Axis Regulates Vasculogenic Mimicry Formation in Breast Cancer Cells. Lim D, Cho JG, Yun E, Lee A, Ryu HY, Lee YJ, Yoon S, Chang W, Lee MS, Kwon BS, Kim J. Genes (Basel). 2020 Dec 23; 2020 Dec 23. PMID: 33374832.", + "Xenopus gpx3 Mediates Posterior Development by Regulating Cell Death during Embryogenesis. Lee H, Ismail T, Kim Y, Chae S, Ryu HY, Lee DS, Kwon TK, Park TJ, Kwon T, Lee HS. Antioxidants (Basel). 2020 Dec 12; 2020 Dec 12. PMID: 33322741.", + "Histone sumoylation promotes Set3 histone-deacetylase complex-mediated transcriptional regulation. Ryu HY, Zhao D, Li J, Su D, Hochstrasser M. Nucleic Acids Res. 2020 Dec 2. PMID: 33231641.", + "Epigenetic Mechanisms Contribute to Evolutionary Adaptation of Gene Network Activity under Environmental Selection. Luo X, Song R, Moreno DF, Ryu HY, Hochstrasser M, Acar M. Cell Rep. 2020 Oct 27. PMID: 33113358.", + "SUMO and cellular adaptive mechanisms. Ryu HY, Ahn SH, Hochstrasser M. Exp Mol Med. 2020 Jun; 2020 Jun 26. PMID: 32591648.", + "Symmetric dimethylation on histone H4R3 associates with histone deacetylation to maintain properly polarized cell growth. Duan R, Ryu HY, Ahn SH. Res Microbiol. 2020 Mar; 2019 Sep 28. PMID: 31574302.", + "The Ulp2 SUMO protease promotes transcription elongation through regulation of histone sumoylation. Ryu HY, Su D, Wilson-Eisele NR, Zhao D, López-Giráldez F, Hochstrasser M. EMBO J. 2019 Aug 15; 2019 Jul 17. PMID: 31313851.", + "Yeast symmetric arginine methyltransferase Hsl7 has a repressive role in transcription. Ryu HY, Duan R, Ahn SH. Res Microbiol. 2019 Jun-Aug; 2019 Jan 17. PMID: 30660775.", + "Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease. Ryu HY, López-Giráldez F, Knight J, Hwang SS, Renner C, Kreft SG, Hochstrasser M. Nat Commun. 2018 Dec 21; 2018 Dec 21. PMID: 30575729.", + "Adaptive aneuploidy counters a dysregulated SUMO system. Ryu HY, Hochstrasser M. Cell Cycle. 2017 Mar 4; 2016 Nov 18. PMID: 27860533.", + "Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy. Ryu HY, Wilson NR, Mehta S, Hwang SS, Hochstrasser M. Genes Dev. 2016 Aug 15; 2016 Sep 1. PMID: 27585592.", + "Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic rDNA condensation. Ryu HY, Ahn S. BMC Biol. 2014 Sep 24; 2014 Sep 24. PMID: 25248920.", + "Loss of the Set2 histone methyltransferase increases cellular lifespan in yeast cells. Ryu HY, Rhie BH, Ahn SH. Biochem Biophys Res Commun. 2014 Mar 28; 2014 Mar 6. PMID: 24607280.", + "The RNA polymerase II Rpb4/7 subcomplex regulates cellular lifespan through an mRNA decay process. Duan R, Rhie BH, Ryu HY, Ahn SH. Biochem Biophys Res Commun. 2013 Nov 8. PMID: 24358479.", + "Cellular aging is associated with increased ubiquitylation of histone H2B in yeast telomeric heterochromatin. Rhie BH, Song YH, Ryu HY, Ahn SH. Biochem Biophys Res Commun. 2013 Oct 4; 2013 Sep 8. PMID: 24025678.", + "Bass Center 266 Whitney Avenue New Haven, CT 06511", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Hoh Lab", + "lab_url": "https://medicine.yale.edu/lab/hoh/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Horvath Lab", + "lab_url": "https://medicine.yale.edu/lab/horvath/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/horvath/publications/", + "publications": null + }, + { + "lab_name": "Housing and Health Equity Lab", + "lab_url": "https://medicine.yale.edu/lab/handh/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/handh/publications", + "publications": null + }, + { + "lab_name": "HPV Working Group", + "lab_url": "https://medicine.yale.edu/lab/niccolai/", + "research_bio": "INFORMATION FOR The HPV Working Group is committed to protecting the future health of today’s youth by bringing together a diverse group of people with an interest in promoting uptake of human papillomavirus (HPV) vaccines. Current vaccines against HPV are safe and effective for preventing infection with this common virus that can cause six types of cancer. Vaccination is currently recommended for boys and girls at ages 11 or 12 years and can be given up to age 26 years. For those who receive their first dose before 15 years of age, only two doses are needed. Despite the promise of this vaccine, most Connecticut adolescents are still not vaccinated as recommended nearly ten years after the vaccine’s FDA approval. Our goal is to develop and implement evidence-based strategies to improve HPV vaccination uptake and decrease the burden of HPV-related diseases in Connecticut. To achieve this goal, the HPV Working Group brings together researchers and other stakeholders who are committed to addressing the problem of low HPV vaccine uptake. Current projects include research efforts to understand barriers to HPV vaccine uptake, surveillance projects to monitor HPV vaccine impact, and intervention development to increase coverage. Sources of support for our work include the National Institutes of Health (National Cancer InstituteandEunice Kennedy Shriver National Institute of Child Health and Human Development), the Centers for Disease Control and Prevention (CT Emerging Infections Program), theYale Cancer Center, and the Robert E. Leet and Clara Guthrie Patterson Trust Fellowship Program in Clinical Research. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/niccolai/publications/", + "publications": [ + "Yale School of Public Health /", + "Projects", + "Publications", + "News and Media", + "People", + "Prospective Students", + "Alumni", + "Donors", + "Employers", + "Academic Calendar", + "myYSPH Members", + "Support YSPH", + "Projects", + "Publications", + "News and Media", + "People", + "", + "", + "", + "", + "", + "", + "Clinical effectiveness of HPV vaccine by age at vaccination: a matched case-control study. Oliveira CR, Shapiro ED, Sheth SS, Ellingson MK, Johnson NP, Sullivan EL, Querec TD, Unger ER, Niccolai LM. Lancet Reg Health Am. 2025 Nov; 2025 Sep 16. PMID: 41019517.", + "At-home self-collection device offers an effective and preferred method to engage high BMI women in cervical cancer screening: method comparison study. Kaplan C, Crane L, Collins A, Parker RL, Orso R, McNicholas C, Sutton E, Memmel L, Conageski C, Hwang Y, Kuroki L, Coleman J, Sheth SS, Harshberger K, Jennings A, Aviki E, Harper D, Mukherjee M, Hibler K, Fitzpatrick MB. Arch Gynecol Obstet. 2025 Oct 3; 2025 Oct 3. PMID: 41042323.", + "Factors Associated With Timely Receipt of Colposcopy After Abnormal Cervical Cancer Screening. Patel AV, Qiu W, Sartor R, Wilcox M, Jones BA, Hernandez-Ramirez RU, Tang W, Megiel S, Girgis A, Foster J, Tong G, Spiegelman D, Sheth SS. J Low Genit Tract Dis. 2025 Oct 1; 2025 Jul 16. PMID: 40631578.", + "Epidemiologic, clinical, and economic burden of anogenital warts among adults: A global systematic review. You X, Valente S, Machalek DA, Felsher M, Pieniazek I, Nowicka K, Tota JE, Chen YT, Niccolai LM, Cui F. Int J Infect Dis. 2025 Aug 27; 2025 Aug 27. PMID: 40882763.", + "Clinical Validation of a Vaginal Cervical Cancer Screening Self-Collection Method for At-Home Use: A Nonrandomized Clinical Trial. Fitzpatrick MB, Behrens CM, Hibler K, Parsons C, Kaplan C, Orso R, Parker L, Memmel L, Collins A, McNicholas C, Crane L, Hwang Y, Sutton E, Coleman J, Kuroki L, Harshberger K, Williams S, Jennings A, Buccini F, Gillis L, Novetsky AP, Hawkes D, Saville M, Depel T, Aviki E, Sheth SS, Conageski C. JAMA Netw Open. 2025 May 1; 2025 May 1. PMID: 40388167.", + "Trends in Cervical Precancers Identified Through Population-Based Surveillance - Human Papillomavirus Vaccine Impact Monitoring Project, Five Sites, United States, 2008-2022. Gargano JW, Stefanos R, Dahl RM, Castilho JL, Bostick EA, Niccolai LM, Park IU, Blankenship S, Brackney MM, Chan K, Delikat EL, Ehlers S, Barrera KG, Kurtz R, Meek JI, Whitney E, Vigar M, Unger ER, Markowitz LE. MMWR Morb Mortal Wkly Rep. 2025 Feb 27; 2025 Feb 27. PMID: 40014651.", + "Reduction in Unindicated Cervical Cancer Screening in Adolescents in a Large Health Care System. Geng B, Oliveira CR, Hosier H, Sheth SS, Vash-Margita A. J Low Genit Tract Dis. 2024 Oct 1; 2024 Jul 23. PMID: 39037856.", + "U.S. Women with Invasive Cervical Cancer: Characteristics and Potential Barriers to Prevention. Rosenblum HG, Gargano JW, Cleveland AA, Dahl RM, Park IU, Whitney E, Castilho JL, Sackey E, Niccolai LM, Brackney M, Debess E, Ehlers S, Bennett NM, Kurtz R, Unger ER, Markowitz LE. J Womens Health (Larchmt). 2024 May; 2024 Apr 12. PMID: 38608239.", + "Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147). Sheth SS, Oh JE, Bellone S, Siegel ER, Greenman M, Mutlu L, McNamara B, Pathy S, Clark M, Azodi M, Altwerger G, Andikyan V, Huang G, Ratner E, Kim DJ, Iwasaki A, Levi AW, Buza N, Hui P, Flaherty S, Schwartz PE, Santin AD. Clin Cancer Res. 2024 May 1. PMID: 38592381.", + "Human Papillomavirus Vaccination Status and Correlates Among Mid-Adult Women: Connecticut, USA, 2016-2019. Sheth SS, Johnson NP, Sullivan EL, Torres AR, Oliveira CR, Niccolai LM. J Womens Health (Larchmt). 2024 Jan; 2023 Nov 9. PMID: 37943625.", + "Uptake of Cervical Cancer Screening Among Female Patients Using a Mobile Medical Clinic. Degife EA, Oliveira CR, Znamierowski E, Meyer JP, Sheth SS. Am J Prev Med. 2023 Nov; 2023 May 21. PMID: 37220860.", + "Factors associated with receiving results and attending colposcopy in patients with positive HPV screens in Mexico City. León-Maldonado L, Hernández-Ramírez RU, Torres-Ibarra L, Spiegelman D, Sheth SS, Lazcano E, Cadena-Fiscal JD, Salmerón J. Prev Med Rep. 2023 Oct; 2023 Jul 24. PMID: 37593354.", + "Human papillomavirus vaccine effectiveness by age at vaccination: A systematic review. Ellingson MK, Sheikha H, Nyhan K, Oliveira CR, Niccolai LM. Hum Vaccin Immunother. 2023 Aug 1. PMID: 37529935.", + "Understanding the Factors Influencing Health Care Provider Recommendations about Adolescent Vaccines: A Proposed Framework. Ellingson MK, Bednarczyk RA, O'Leary ST, Schwartz JL, Shapiro ED, Niccolai LM. J Behav Med. 2023 Apr; 2022 Feb 22. PMID: 35194726.", + "Messaging of Different Disease Outcomes for Human Papillomavirus Vaccination: A Systematic Review. Niccolai LM, Johnson NP, Torres A, Sullivan EL, Hansen CE. J Adolesc Health. 2023 Mar; 2022 Dec 16. PMID: 36529616.", + "HPV type-specific trends in cervical precancers in the United States, 2008 to 2016. Gargano JW, McClung N, Lewis RM, Park IU, Whitney E, Castilho JL, Pemmaraju M, Niccolai LM, Brackney M, DeBess E, Ehlers S, Bennett NM, Scahill M, Cleveland AA, Querec TD, Unger ER, Markowitz LE. Int J Cancer. 2023 Jan 15; 2022 Sep 26. PMID: 35904861.", + "Clinical and Public Health Considerations for HPV Vaccination in Midadulthood: A Narrative Review. King LM, Lewnard JA, Niccolai LM. Open Forum Infect Dis. 2023 Jan; 2023 Jan 11. PMID: 36726535.", + "A review of data systems for assessing the impact of HPV vaccination in selected high-income countries. Wang WV, Kothari S, Khoury H, Niccolai L, Garland SM, Sundström K, de Pouvourville G, Bonanni P, Chen YT, Franco EL. Expert Rev Vaccines. 2023 Jan-Dec; 2023 Jan 9. PMID: 36576068.", + "Parents' Acceptance of COVID-19 Compared to Human Papillomavirus Vaccines. Footman A, Kanney N, Niccolai LM, Zimet GD, Overton ET, Davies SL, Van Der Pol B. J Adolesc Health. 2022 Dec; 2022 Oct 5. PMID: 36208985.", + "Chlamydia Vaccination: Parent Opinions and Implications for Future Promotion Programs. Footman A, Kanney N, Niccolai LM, Zimet GD, Overton ET, Davies SL, Van Der Pol B. Sex Transm Dis. 2022 Nov 1; 2022 Aug 11. PMID: 35948303.", + "Perceived Need and Acceptance of a Future Chlamydia Vaccine Among Health Care Providers. Footman A, Kanney N, Niccolai LM, Zimet GD, Overton ET, Davies SL, Van Der Pol B. Sex Transm Dis. 2022 Nov 1; 2022 Jun 17. PMID: 35709184.", + "Trends in Precancerous Cervical Lesions by Area-Based Measures of Poverty, Race, and Ethnicity, Connecticut, 2008-2018. Brackney MM, Weinberger DM, Higgins K, Meek J, Niccolai LM. Public Health Rep. 2022 Nov-Dec; 2021 Nov 2. PMID: 34727517.", + "Neuropsychological Functioning in Primary Dystonia: Updated and Expanded Multidomain Meta-Analysis. Aita SL, Del Bene VA, Marotta DA, Pizer JH, Hawley NA, Niccolai L, Walker HC, Gerstenecker A, Martin RC, Clay OJ, Crowe M, Triebel KL, Hill BD. Mov Disord. 2022 Jul; 2022 Apr 6. PMID: 35385165.", + "State Laws Permitting Adolescent Consent to Human Papillomavirus Vaccination and Rates of Immunization. Torres AR, Johnson NP, Ellingson MK, Hansen CE, Oliveira CR, Niccolai LM, Sheth SS. JAMA Pediatr. 2022 Feb 1. PMID: 34779839.", + "Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States. Hosier H, Sheth SS, Oliveira CR, Perley LE, Vash-Margita A. Am J Obstet Gynecol. 2021 Dec; 2021 Jul 10. PMID: 34256029.", + "Factors Associated With Receipt of Meningococcal B Vaccine Among United States Adolescents, National Immunization Survey-Teen, 2017-2018. Hansen CE, Niccolai LM. J Adolesc Health. 2021 Nov; 2021 Jun 17. PMID: 34148798.", + "Median Age at HPV Infection Among Women in the United States: A Model-Based Analysis Informed by Real-world Data. Prabhu VS, Roberts CS, Kothari S, Niccolai L. Open Forum Infect Dis. 2021 Jul; 2021 Mar 12. PMID: 34888404.", + "Patterns of recommended vaccine receipt among women ages 24-45 years: a cross-sectional analysis. Ellingson MK, Oliveira CR, Sheth SS, Sullivan EL, Torres A, Shapiro ED, Niccolai LM. BMC Public Health. 2021 Jul 1; 2021 Jul 1. PMID: 34193100.", + "Increases in Human Papillomavirus Testing Preceding Diagnosis of Cervical Precancer in 5 US States, 2008-2016. Cleveland AA, Gargano JW, Griffin MR, Park IU, Niccolai LM, Bennett NM, Pemmaraju M, Fink D, Brackney M, Scahill M, Ehlers SJ, Unger ER, Markowitz LE. J Low Genit Tract Dis. 2021 Jul 1. PMID: 33797511.", + "Inpatient Immunization With HPV Vaccine: A Qualitative Study With Postpartum Women. Avni-Singer L, Oliveira CR, Torres A, Shapiro ED, Niccolai LM, Sheth SS. Womens Health Issues. 2021 Jul-Aug; 2021 Mar 11. PMID: 33715924.", + "Impact of reduced human papillomavirus vaccination coverage rates due to COVID-19 in the United States: A model based analysis. Daniels V, Saxena K, Roberts C, Kothari S, Corman S, Yao L, Niccolai L. Vaccine. 2021 May 12; 2021 Apr 6. PMID: 33875269.", + "Effectiveness of HPV vaccine by age at vaccination and number of doses: protocol for a population-based matched case-control study. Oliveira CR, Ortiz AM, Sheth SS, Shapiro ED, Niccolai LM. BMJ Open. 2021 Apr 19; 2021 Apr 19. PMID: 33875441.", + "Association of Inadvertent 9-Valent Human Papillomavirus Vaccine in Pregnancy With Spontaneous Abortion and Adverse Birth Outcomes. Kharbanda EO, Vazquez-Benitez G, DeSilva MB, Naleway AL, Klein NP, Hechter RC, Glanz JM, Donahue JG, Jackson LA, Sheth SS, Greenberg V, Panagiotakopoulos L, Mba-Jonas A, Lipkind HS. JAMA Netw Open. 2021 Apr 1; 2021 Apr 1. PMID: 33818618.", + "Monitoring HPV vaccine impact on cervical disease: Status and future directions for the era of cervical cancer elimination. Oliveira CR, Niccolai LM. Prev Med. 2021 Mar; 2021 Mar 4. PMID: 33678234.", + "A world without cervical cancer is within our reach. Giuliano AR, Niccolai LM. Prev Med. 2021 Mar; 2021 Mar 4. PMID: 33678224.", + "Suboptimal uptake of meningococcal vaccines among older adolescents: Barriers, solutions, and future research directions. Niccolai LM, Hansen CE. Hum Vaccin Immunother. 2020 Dec 1; 2020 Jul 2. PMID: 32614695.", + "Natural Language Processing for Surveillance of Cervical and Anal Cancer and Precancer: Algorithm Development and Split-Validation Study. Oliveira CR, Niccolai P, Ortiz AM, Sheth SS, Shapiro ED, Niccolai LM, Brandt CA. JMIR Med Inform. 2020 Nov 3; 2020 Nov 3. PMID: 32469840.", + "Evaluation of an Inpatient Postpartum Human Papillomavirus Immunization Program. Avni-Singer L, Oliveira CR, Torres A, Shapiro ED, Niccolai LM, Sheth SS. Obstet Gynecol. 2020 Nov. PMID: 33030866.", + "Disparities in the Epidemiology of Anal Cancer: A Cross-Sectional Time Series. Oliveira CR, Niu YS, Einarsdottir HM, Niccolai LM, Shapiro ED. Health Equity. 2020; 2020 Sep 16. PMID: 32964175.", + "Human Papillomavirus 16/18-Associated Cervical Lesions: Differences by Area-Based Measures of Race and Poverty. Brackney MM, Gargano JW, Hannagan SE, Meek J, Querec TD, Niccolai LM. Am J Prev Med. 2020 May; 2020 Jan 28. PMID: 32001053.", + "Effectiveness of 1, 2, and 3 Doses of Human Papillomavirus Vaccine Against High-Grade Cervical Lesions Positive for Human Papillomavirus 16 or 18. Johnson Jones ML, Gargano JW, Powell M, Park IU, Niccolai LM, Bennett NM, Griffin MR, Querec T, Unger ER, Markowitz LE. Am J Epidemiol. 2020 Apr 2. PMID: 31680146.", + "Cognitive Bias in Clinicians' Communication about Human Papillomavirus Vaccination. Hansen CE, North A, Niccolai LM. Health Commun. 2020 Apr; 2019 Jan 24. PMID: 30676109.", + "Cervical adenocarcinoma in situ: Human papillomavirus types and incidence trends in five states, 2008-2015. Cleveland AA, Gargano JW, Park IU, Griffin MR, Niccolai LM, Powell M, Bennett NM, Saadeh K, Pemmaraju M, Higgins K, Ehlers S, Scahill M, Johnson Jones ML, Querec T, Markowitz LE, Unger ER. Int J Cancer. 2020 Feb 1; 2019 May 6. PMID: 30980692.", + "Feasibility and Accuracy of a Computer-Assisted Self-Interviewing Instrument to Ascertain Prior Immunization With Human Papillomavirus Vaccine by Self-Report: Cross-Sectional Analysis. Oliveira CR, Avni-Singer L, Badaro G, Sullivan EL, Sheth SS, Shapiro ED, Niccolai LM. JMIR Med Inform. 2020 Jan 22; 2020 Jan 22. PMID: 32012073.", + "Trends in Anogenital Wart Diagnoses in Connecticut, 2013-2017. Yakely AE, Niccolai LM, Oliveira CR. JAMA Netw Open. 2020 Jan 3; 2020 Jan 3. PMID: 32003814.", + "Assessing sociodemographic differences in human papillomavirus vaccine impact studies in the United States: a systematic review using narrative synthesis. Avni-Singer LR, Yakely A, Sheth SS, Shapiro ED, Niccolai LM, Oliveira CR. Public Health. 2020 Jan; 2019 Nov 4. PMID: 31698136.", + "Compliance with cervical cancer screening guidelines in young female patients: rates and trends of screening in New Haven County, CT. Oliveira CR, Hosier H, Pate B, Niccolai LM, Sheth SS, Vash-Margita A. Am J Obstet Gynecol. 2019 Nov; 2019 Jul 4. PMID: 31279847.", + "Up-to-date coverage with meningococcal vaccine among adolescents age 17 years: Patterns and correlates in the United States, 2017. Niccolai LM, Yakely AE, Hansen CE. Vaccine. 2019 Sep 20; 2019 Aug 28. PMID: 31473004.", + "Missed Opportunities for HPV Vaccination Among Vaccine-Eligible Women with High Grade Cervical Lesions. Russ SM, Brackney M, Meek J, Niccolai LM. Vaccine. 2019 Jul 18; 2019 Jun 24. PMID: 31248688.", + "Estimated Number of Cases of High-Grade Cervical Lesions Diagnosed Among Women - United States, 2008 and 2016. McClung NM, Gargano JW, Park IU, Whitney E, Abdullah N, Ehlers S, Bennett NM, Scahill M, Niccolai LM, Brackney M, Griffin MR, Pemmaraju M, Querec TD, Cleveland AA, Unger ER, Markowitz LE. MMWR Morb Mortal Wkly Rep. 2019 Apr 19; 2019 Apr 19. PMID: 30998672.", + "Trends in High-grade Cervical Lesions and Cervical Cancer Screening in 5 States, 2008-2015. Gargano JW, Park IU, Griffin MR, Niccolai LM, Powell M, Bennett NM, Johnson Jones ML, Whitney E, Pemmaraju M, Brackney M, Abdullah N, Scahill M, Dahl RM, Cleveland AA, Unger ER, Markowitz LE. Clin Infect Dis. 2019 Apr 8. PMID: 30137283.", + "Human Papillomavirus Vaccination and Anogenital Warts: A Systematic Review of Impact and Effectiveness in the United States. Yakely AE, Avni-Singer L, Oliveira CR, Niccolai LM. Sex Transm Dis. 2019 Apr. PMID: 30461595.", + "Trends in Human Papillomavirus Vaccine Types 16 and 18 in Cervical Precancers, 2008-2014. McClung NM, Gargano JW, Bennett NM, Niccolai LM, Abdullah N, Griffin MR, Park IU, Cleveland AA, Querec TD, Unger ER, Markowitz LE. Cancer Epidemiol Biomarkers Prev. 2019 Mar; 2019 Feb 21. PMID: 30792242.", + "Risk of Spontaneous Abortion After Inadvertent Human Papillomavirus Vaccination in Pregnancy. Kharbanda EO, Vazquez-Benitez G, Lipkind HS, Sheth SS, Zhu J, Naleway AL, Klein NP, Hechter R, Daley MF, Donahue JG, Jackson ML, Kawai AT, Sukumaran L, Nordin JD. Obstet Gynecol. 2018 Jul. PMID: 29889760.", + "Impact of a clinical interventions bundle on uptake of HPV vaccine at an OB/GYN clinic. Deshmukh U, Oliveira CR, Griggs S, Coleman E, Avni-Singer L, Pathy S, Shapiro ED, Sheth SS. Vaccine. 2018 Jun 14; 2018 May 11. PMID: 29759380.", + "Lack of school requirements and clinician recommendations for human papillomavirus vaccination. Niccolai LM, North AL, Footman A, Hansen CE. J Public Health Res. 2018 Feb 5; 2018 Apr 23. PMID: 29780768.", + "Missed opportunities for HPV immunization among young adult women. Oliveira CR, Rock RM, Shapiro ED, Xu X, Lundsberg L, Zhang LB, Gariepy A, Illuzzi JL, Sheth SS. Am J Obstet Gynecol. 2018 Mar; 2017 Dec 6. PMID: 29223597.", + "Knowledge and beliefs regarding cervical cancer screening and HPV vaccination among urban and rural women in León, Nicaragua. Rees HD, Lombardo AR, Tangoren CG, Meyers SJ, Muppala VR, Niccolai LM. PeerJ. 2017; 2017 Oct 25. PMID: 29085745.", + "Declines in Human Papillomavirus (HPV)-Associated High-Grade Cervical Lesions After Introduction of HPV Vaccines in Connecticut, United States, 2008-2015. Niccolai LM, Meek JI, Brackney M, Hadler JL, Sosa LE, Weinberger DM. Clin Infect Dis. 2017 Sep 15. PMID: 28520854.", + "Acceptability of School-Based Health Centers for Human Papillomavirus Vaccination Visits: A Mixed-Methods Study. Hansen CE, Okoloko E, Ogunbajo A, North A, Niccolai LM. J Sch Health. 2017 Sep. PMID: 28766319.", + "The Role of Cognitive Bias in Suboptimal HPV Vaccine Uptake. Niccolai LM, Pettigrew MM. Pediatrics. 2016 Oct; 2016 Sep 9. PMID: 27613774.", + "State-Level Voting Patterns and Adolescent Vaccination Coverage in the United States, 2014. Bernstein S, North A, Schwartz J, Niccolai LM. Am J Public Health. 2016 Oct; 2016 Aug 23. PMID: 27552268.", + "Human Papillomavirus Vaccination Requirements in US Schools: Recommendations for Moving Forward. North AL, Niccolai LM. Am J Public Health. 2016 Oct; 2016 Aug 23. PMID: 27552264.", + "\"I think they're all basically the same\": parents' perceptions of human papilloma virus (HPV) vaccine compared with other adolescent vaccines. Ogunbajo A, Hansen CE, North AL, Okoloko E, Niccolai LM. Child Care Health Dev. 2016 Jul; 2016 Mar 15. PMID: 26990908.", + "Parents' Recall and Reflections on Experiences Related to HPV Vaccination for Their Children. Niccolai LM, Hansen CE, Credle M, Shapiro ED. Qual Health Res. 2016 May; 2015 Mar 16. PMID: 25779984.", + "\"It All Depends\": A Qualitative Study of Parents' Views of Human Papillomavirus Vaccine for their Adolescents at Ages 11-12 years. Hansen CE, Credle M, Shapiro ED, Niccolai LM. J Cancer Educ. 2016 Mar. PMID: 25600376.", + "Human papillomavirus vaccine acceptability among female undergraduate students in China: the role of knowledge and psychosocial factors. Gu C, Niccolai LM, Yang S, Wang X, Tao L. J Clin Nurs. 2015 Oct; 2015 Jul 14. PMID: 26179945.", + "Monitoring Effect of Human Papillomavirus Vaccines in US Population, Emerging Infections Program, 2008-2012. Hariri S, Markowitz LE, Bennett NM, Niccolai LM, Schafer S, Bloch K, Park IU, Scahill MW, Julian P, Abdullah N, Levine D, Whitney E, Unger ER, Steinau M, Bauer HM, Meek J, Hadler J, Sosa L, Powell SE, Johnson ML. Emerg Infect Dis. 2015 Sep. PMID: 26291379.", + "Population-based trends in high-grade cervical lesions in the early human papillomavirus vaccine era in the United States. Hariri S, Johnson ML, Bennett NM, Bauer HM, Park IU, Schafer S, Niccolai LM, Unger ER, Markowitz LE. Cancer. 2015 Aug 15; 2015 Jun 22. PMID: 26098295.", + "Practice- and Community-Based Interventions to Increase Human Papillomavirus Vaccine Coverage: A Systematic Review. Niccolai LM, Hansen CE. JAMA Pediatr. 2015 Jul. PMID: 26010507.", + "Population-level impact and herd effects following human papillomavirus vaccination programmes: a systematic review and meta-analysis. Drolet M, Bénard É, Boily MC, Ali H, Baandrup L, Bauer H, Beddows S, Brisson J, Brotherton JM, Cummings T, Donovan B, Fairley CK, Flagg EW, Johnson AM, Kahn JA, Kavanagh K, Kjaer SK, Kliewer EV, Lemieux-Mellouki P, Markowitz L, Mboup A, Mesher D, Niccolai L, Oliphant J, Pollock KG, Soldan K, Sonnenberg P, Tabrizi SN, Tanton C, Brisson M. Lancet Infect Dis. 2015 May; 2015 Mar 3. PMID: 25744474.", + "Reduction in HPV 16/18-associated high grade cervical lesions following HPV vaccine introduction in the United States - 2008-2012. Hariri S, Bennett NM, Niccolai LM, Schafer S, Park IU, Bloch KC, Unger ER, Whitney E, Julian P, Scahill MW, Abdullah N, Levine D, Johnson ML, Steinau M, Markowitz LE. Vaccine. 2015 Mar 24; 2015 Feb 11. PMID: 25681664.", + "HPV type attribution in high-grade cervical lesions: assessing the potential benefits of vaccines in a population-based evaluation in the United States. Hariri S, Unger ER, Schafer S, Niccolai LM, Park IU, Bloch KC, Bennett NM, Steinau M, Johnson ML, Markowitz LE. Cancer Epidemiol Biomarkers Prev. 2015 Feb; 2014 Nov 21. PMID: 25416715.", + "Parents' views on human papillomavirus vaccination for sexually transmissible infection prevention: a qualitative study. Niccolai LM, Hansen CE, Credle M, Ryan SA, Shapiro ED. Sex Health. 2014 Jul. PMID: 24990400.", + "Public awareness of head and neck cancers: a cross-sectional survey. Luryi AL, Yarbrough WG, Niccolai LM, Roser S, Reed SG, Nathan CA, Moore MG, Day T, Judson BL. JAMA Otolaryngol Head Neck Surg. 2014 Jul. PMID: 24902640.", + "Interactive effects of individual and neighborhood race and ethnicity on rates of high-grade cervical lesions. Waggaman C, Julian P, Niccolai LM. Cancer Epidemiol. 2014 Jun; 2014 Apr 4. PMID: 24704286.", + "Sources of information for assessing human papillomavirus vaccination history among young women. Niccolai LM, McBride V, Julian PR. Vaccine. 2014 May 23; 2014 Apr 5. PMID: 24713369.", + "The prevalence of HPV associated cervical intraepithelial neoplasia in women under age 21: who will be missed under the new cervical cancer screening guidelines? DeCew AE, Hadler JL, Daley AM, Niccolai L. J Pediatr Adolesc Gynecol. 2013 Dec; 2013 Oct 9. PMID: 24119656.", + "Niccolai et al. respond. Niccolai LM, Julian PJ, Meek JI, Hadler JL, Sosa L. Am J Public Health. 2013 Oct; 2013 Aug 15. PMID: 23947315.", + "Individual and geographic disparities in human papillomavirus types 16/18 in high-grade cervical lesions: Associations with race, ethnicity, and poverty. Niccolai LM, Russ C, Julian PJ, Hariri S, Sinard J, Meek JI, McBride V, Markowitz LE, Unger ER, Hadler JL, Sosa LE. Cancer. 2013 Aug 15; 2013 May 9. PMID: 23661284.", + "Declining rates of high-grade cervical lesions in young women in Connecticut, 2008-2011. Niccolai LM, Julian PJ, Meek JI, McBride V, Hadler JL, Sosa LE. Cancer Epidemiol Biomarkers Prev. 2013 Aug; 2013 May 23. PMID: 23704476.", + "Geographic poverty and racial/ethnic disparities in cervical cancer precursor rates in Connecticut, 2008-2009. Niccolai LM, Julian PJ, Bilinski A, Mehta NR, Meek JI, Zelterman D, Hadler JL, Sosa L. Am J Public Health. 2013 Jan; 2012 Apr 19. PMID: 22515856.", + "Impact of human papillomavirus (HPV) vaccination on HPV 16/18-related prevalence in precancerous cervical lesions. Powell SE, Hariri S, Steinau M, Bauer HM, Bennett NM, Bloch KC, Niccolai LM, Schafer S, Unger ER, Markowitz LE. Vaccine. 2012 Dec 17; 2012 Nov 6. PMID: 23137842.", + "Human papillomavirus genotypes in high-grade cervical lesions in the United States. Hariri S, Unger ER, Powell SE, Bauer HM, Bennett NM, Bloch KC, Niccolai LM, Schafer S, Steinau M, Markowitz LE. J Infect Dis. 2012 Dec 15; 2012 Oct 8. PMID: 23045628.", + "Human papillomavirus vaccination history among women with precancerous cervical lesions: disparities and barriers. Mehta NR, Julian PJ, Meek JI, Sosa LE, Bilinski A, Hariri S, Markowitz LE, Hadler JL, Niccolai LM. Obstet Gynecol. 2012 Mar. PMID: 22353956.", + "The HPV vaccine impact monitoring project (HPV-IMPACT): assessing early evidence of vaccination impact on HPV-associated cervical cancer precursor lesions. Hariri S, Unger ER, Powell SE, Bauer HM, Bennett NM, Bloch KC, Niccolai LM, Schafer S, Markowitz LE. Cancer Causes Control. 2012 Feb; 2011 Nov 23. PMID: 22108842.", + "Knowledge of human papillomavirus and anal cancer among men who have sex with men attending a New York City sexually transmitted diseases clinic. Sanchez DM, Pathela P, Niccolai LM, Schillinger JA. Int J STD AIDS. 2012 Jan. PMID: 22362686.", + "Racial/Ethnic and poverty disparities in human papillomavirus vaccination completion. Niccolai LM, Mehta NR, Hadler JL. Am J Prev Med. 2011 Oct. 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HRL analyzes and preserves open source and remote sensing data, including satellite imagery and information shared via social media, consistent with international legal standards for use in ongoing and future accountability mechanisms. This includes maintaining rigorous chain-of-custody procedures for preservation and accountability mechanisms. Real-time analyses of these data provide support to partners delivering healthcare and responding to population needs in conflict settings. The Yale School of Public Health’s Humanitarian Research Lab (HRL) has concluded that children from Ukraine have been taken to at least 210 facilities inside Russia and temporarily occupied territory of Ukraine since Russia’s full-scale invasion of Ukraine in February 2022. Overview of Yale HRL investigations into Russia’s deportation, re-education, and placement of Ukraine’s children. Copy Link Learn about upcoming publications, deadlines and speakers.", + "publications_page": "https://medicine.yale.edu/lab/khoshnood/projects/data-responsibility/submissions/", + "publications": [ + "Yale School of Public Health /", + "Projects Data Responsibility Editorial Board and Staff Authors and Review Process Call for Papers and Submissions", + "Data Responsibility Editorial Board and Staff Authors and Review Process Call for Papers and Submissions", + "Editorial Board and Staff", + "Authors and Review Process", + "Call for Papers and Submissions", + "Publications & Reports Reports", + "Reports", + "Conflict Observatory Ukraine Conflict Observatory", + "Ukraine Conflict Observatory", + "News", + "Courses", + "Give Now", + "Team", + "Prospective Students", + "Alumni", + "Donors", + "Employers", + "Academic Calendar", + "myYSPH Members", + "Support YSPH", + "Home", + "Projects", + "Data Responsibility", + "Editorial Board and Staff", + "Authors and Review Process", + "Call for Papers and Submissions", + "", + "", + "", + "", + "", + "", + "define data responsibility pedagogically and practically; and", + "identify the tradeoffs and tensions organizations encounter in their efforts to be ‘data responsible’ towards marginalized and/or highly vulnerable populations. This volume seeks to define data responsibility based on the premises that different organizations have different 'centers of gravity,' which may not be explicitly stated and acknowledged, and that these centers of gravity produce recurring tensions and tradeoffs. ‘Centers of gravity’ are defined in this series as the primary liabilities actors are trying to prevent and the primary objectives they are trying to achieve through data and information and communication technologies (ICTs). Data and information communication technologies may include data acquisition methods, e.g. CDR, Remote Sensing, Big Data, Mobile Data collection, participatory mapping (e.g. HotOSM) as well as other digital tools used for data collection, storage, and analysis. The sectors relevant to this series use data for a variety of different but commonly repeating purposes. These include, though are not limited to: advocacy, mapping and targeting, resource allocation, communicating with communities, connecting populations to services, service delivery and supply chain tracking, and registration and identity management.", + "Abstract (350 words) (format) (Please note that we will accept fully written papers if available.)", + "short explanation identifying which tension (above) your proposed paper is responding to.", + "(Optional) Description of Methodology", + "hrl@yale.edu", + "PO Box 208034 New Haven, CT 06520-8034", + "Contact Us", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Hwa Lab", + "lab_url": "https://medicine.yale.edu/lab/hwa/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/hwa/publications", + "publications": null + }, + { + "lab_name": "Hwang Lab", + "lab_url": "https://medicine.yale.edu/lab/hwang/", + "research_bio": "INFORMATION FOR Welcome to the Hwang Lab! Our mission:to understand the effects of obesity and diabetes on the brain in order to develop better treatments and preventative strategies for these diseases. To achieve our mission, we conduct rigorous high-quality clinical and translational studies to understand the mechanisms underlying obesity, diabetes and their effects in the brain. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/hwang/publications/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Endocrinology /", + "Research Project 1: Hypoglycemia and the Brain Project 2: Hyperglycemia and the Brain Project 3: Aging and the Brain Project 4: Brown Adipose Tissue Imaging", + "Project 1: Hypoglycemia and the Brain", + "Project 2: Hyperglycemia and the Brain", + "Project 3: Aging and the Brain", + "Project 4: Brown Adipose Tissue Imaging", + "Lab Members", + "Publications", + "Opportunities", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Lab Members", + "Publications", + "Opportunities", + "", + "", + "", + "", + "", + "", + "Measurement of brain glucose metabolism in obesity and diabetes. Hwang JJ, Bini J, Belfort-DeAguiar R. Diabetologia. 2025 Sep; 2025 Jul 25. PMID: 40711543.", + "Deficits in brain glucose transport among younger adults with obesity. Gunawan F, Matson BC, Coppoli A, Jiang L, Ding Y, Perry R, Sanchez-Rangel E, DeAguiar RB, Behar KL, Rothman DL, Mason GF, Hwang JJ. Obesity (Silver Spring). 2024 Jul; 2024 May 19. PMID: 38764181.", + "Pathophysiology and management of hypoglycemia in diabetes. Sanchez-Rangel E, Deajon-Jackson J, Hwang JJ. Ann N Y Acad Sci. 2022 Dec; 2022 Oct 6. PMID: 36202764.", + "Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity. Anam AK, Cooke KM, Dratver MB, O'Bryan JV, Perley LE, Guller SM, Hwang JJ, Taylor HS, Goedeke L, Kliman HJ, Vatner DF, Flannery CA. Mol Metab. 2022 Oct; 2022 Aug 12. PMID: 35970449.", + "Reversibility of brain glucose kinetics in type 2 diabetes mellitus. Sanchez-Rangel E, Gunawan F, Jiang L, Savoye M, Dai F, Coppoli A, Rothman DL, Mason GF, Hwang JJ. Diabetologia. 2022 May; 2022 Mar 5. PMID: 35247067.", + "Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating. Bini J, Parikh L, Lacadie C, Hwang JJ, Shah S, Rosenberg SB, Seo D, Lam K, Hamza M, De Aguiar RB, Constable T, Sherwin RS, Sinha R, Jastreboff AM. Neuroimage Clin. 2022; 2022 Sep 16. PMID: 36126514.", + "Food for Thought. Hwang JJ. J Nutr. 2021 Aug 7. PMID: 34195820.", + "Glycemic Variability and CNS Inflammation: Reviewing the Connection. Watt C, Sanchez-Rangel E, Hwang JJ. Nutrients. 2020 Dec 21; 2020 Dec 21. PMID: 33371247.", + "Characterizing the Effects of Diabetes and Obesity on Insulin and Leptin Levels amongst Pregnant Women. Johnson AW, Snegovskikh D, Parikh L, DeAguiar RB, Han CS, Hwang JJ. Am J Perinatol. 2020 Sep; 2020 Mar 2. PMID: 32120424.", + "Norepinephrine transporter availability in brown fat is reduced in obesity: a human PET study with [(11)C] MRB. Sanchez-Rangel E, Gallezot JD, Yeckel CW, Lam W, Belfort-DeAguiar R, Chen MK, Carson RE, Sherwin R, Hwang JJ. Int J Obes (Lond). 2020 Apr; 2019 Oct 21. PMID: 31636373.", + "Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes. Parikh L, Seo D, Lacadie C, Belfort-Deaguiar R, Groskreutz D, Hamza M, Dai F, Scheinost D, Sinha R, Todd Constable R, Sherwin R, Hwang JJ. J Clin Endocrinol Metab. 2020 Jan 1. PMID: 31511876.", + "Glycemic Variability and Brain Glucose Levels in Type 1 Diabetes. Hwang JJ, Jiang L, Sanchez Rangel E, Fan X, Ding Y, Lam W, Leventhal J, Dai F, Rothman DL, Mason GF, Sherwin RS. Diabetes. 2019 Jan; 2018 Oct 16. PMID: 30327383.", + "Verapamil is a potential therapy for hypoglycaemic brain injury. Hwang JJ, Sherwin RS. Nat Rev Endocrinol. 2018 Aug. PMID: 29967401.", + "Noradrenergic Activity in the Human Brain: A Mechanism Supporting the Defense Against Hypoglycemia. Belfort-DeAguiar R, Gallezot JD, Hwang JJ, Elshafie A, Yeckel CW, Chan O, Carson RE, Ding YS, Sherwin RS. J Clin Endocrinol Metab. 2018 Jun 1. PMID: 29590401.", + "Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia. Hwang JJ, Parikh L, Lacadie C, Seo D, Lam W, Hamza M, Schmidt C, Dai F, Sejling AS, Belfort-DeAguiar R, Constable RT, Sinha R, Sherwin R. J Clin Invest. 2018 Apr 2; 2018 Mar 5. PMID: 29381484.", + "Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM. Hwang JJ, Jiang L, Hamza M, Sanchez Rangel E, Dai F, Belfort-DeAguiar R, Parikh L, Koo BB, Rothman DL, Mason G, Sherwin RS. JCI Insight. 2017 Oct 19; 2017 Oct 19. PMID: 29046482.", + "The human brain produces fructose from glucose. Hwang JJ, Jiang L, Hamza M, Dai F, Belfort-DeAguiar R, Cline G, Rothman DL, Mason G, Sherwin RS. JCI Insight. 2017 Feb 23; 2017 Feb 23. PMID: 28239653.", + "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). 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Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC Jr, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR Jr, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, Ciarcia R, Ciechomska IA, Ciriolo MR, Cirone M, Claerhout S, Clague MJ, Clària J, Clarke PG, Clarke R, Clementi E, Cleyrat C, Cnop M, Coccia EM, Cocco T, Codogno P, Coers J, Cohen EE, Colecchia D, Coletto L, Coll NS, Colucci-Guyon E, Comincini S, Condello M, Cook KL, Coombs GH, Cooper CD, Cooper JM, Coppens I, Corasaniti MT, Corazzari M, Corbalan R, Corcelle-Termeau E, Cordero MD, Corral-Ramos C, Corti O, Cossarizza A, Costelli P, Costes S, Cotman SL, Coto-Montes A, Cottet S, Couve E, Covey LR, Cowart LA, Cox JS, Coxon FP, Coyne CB, Cragg MS, Craven RJ, Crepaldi T, Crespo JL, Criollo A, Crippa V, Cruz MT, Cuervo AM, Cuezva JM, Cui T, Cutillas PR, Czaja MJ, Czyzyk-Krzeska MF, Dagda RK, Dahmen U, Dai C, Dai W, Dai Y, Dalby KN, Dalla Valle L, Dalmasso G, D'Amelio M, Damme M, Darfeuille-Michaud A, Dargemont C, Darley-Usmar VM, Dasarathy S, Dasgupta B, Dash S, Dass CR, Davey HM, Davids LM, Dávila D, Davis RJ, Dawson TM, Dawson VL, Daza P, de Belleroche J, de Figueiredo P, de Figueiredo RC, de la Fuente J, De Martino L, De Matteis A, De Meyer GR, De Milito A, De Santi M, de Souza W, De Tata V, De Zio D, Debnath J, Dechant R, Decuypere JP, Deegan S, Dehay B, Del Bello B, Del Re DP, Delage-Mourroux R, Delbridge LM, Deldicque L, Delorme-Axford E, Deng Y, Dengjel J, Denizot M, Dent P, Der CJ, Deretic V, Derrien B, Deutsch E, Devarenne TP, Devenish RJ, Di Bartolomeo S, Di Daniele N, Di Domenico F, Di Nardo A, Di Paola S, Di Pietro A, Di Renzo L, DiAntonio A, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dickey CA, Dickson RC, Diederich M, Digard P, Dikic I, Dinesh-Kumar SP, Ding C, Ding WX, Ding Z, Dini L, Distler JH, Diwan A, Djavaheri-Mergny M, Dmytruk K, Dobson RC, Doetsch V, Dokladny K, Dokudovskaya S, Donadelli M, Dong XC, Dong X, Dong Z, Donohue TM Jr, Doran KS, D'Orazi G, Dorn GW 2nd, Dosenko V, Dridi S, Drucker L, Du J, Du LL, Du L, du Toit A, Dua P, Duan L, Duann P, Dubey VK, Duchen MR, Duchosal MA, Duez H, Dugail I, Dumit VI, Duncan MC, Dunlop EA, Dunn WA Jr, Dupont N, Dupuis L, Durán RV, Durcan TM, Duvezin-Caubet S, Duvvuri U, Eapen V, Ebrahimi-Fakhari D, Echard A, Eckhart L, Edelstein CL, Edinger AL, Eichinger L, Eisenberg T, Eisenberg-Lerner A, Eissa NT, El-Deiry WS, El-Khoury V, Elazar Z, Eldar-Finkelman H, Elliott CJ, Emanuele E, Emmenegger U, Engedal N, Engelbrecht AM, Engelender S, Enserink JM, Erdmann R, Erenpreisa J, Eri R, Eriksen JL, Erman A, Escalante R, Eskelinen EL, Espert L, Esteban-Martínez L, Evans TJ, Fabri M, Fabrias G, Fabrizi C, Facchiano A, Færgeman NJ, Faggioni A, Fairlie WD, Fan C, Fan D, Fan J, Fang S, Fanto M, Fanzani A, Farkas T, Faure M, Favier FB, Fearnhead H, Federici M, Fei E, Felizardo TC, Feng H, Feng Y, Feng Y, Ferguson TA, Fernández ÁF, Fernandez-Barrena MG, Fernandez-Checa JC, Fernández-López A, Fernandez-Zapico ME, Feron O, Ferraro E, Ferreira-Halder CV, Fesus L, Feuer R, Fiesel FC, Filippi-Chiela EC, Filomeni G, Fimia GM, Fingert JH, Finkbeiner S, Finkel T, Fiorito F, Fisher PB, Flajolet M, Flamigni F, Florey O, Florio S, Floto RA, Folini M, Follo C, Fon EA, Fornai F, Fortunato F, Fraldi A, Franco R, Francois A, François A, Frankel LB, Fraser ID, Frey N, Freyssenet DG, Frezza C, Friedman SL, Frigo DE, Fu D, Fuentes JM, Fueyo J, Fujitani Y, Fujiwara Y, Fujiya M, Fukuda M, Fulda S, Fusco C, Gabryel B, Gaestel M, Gailly P, Gajewska M, Galadari S, Galili G, Galindo I, Galindo MF, Galliciotti G, Galluzzi L, Galluzzi L, Galy V, Gammoh N, Gandy S, Ganesan AK, Ganesan S, Ganley IG, Gannagé M, Gao FB, Gao F, Gao JX, García Nannig L, García Véscovi E, Garcia-Macía M, Garcia-Ruiz C, Garg AD, Garg PK, Gargini R, Gassen NC, Gatica D, Gatti E, Gavard J, Gavathiotis E, Ge L, Ge P, Ge S, Gean PW, Gelmetti V, Genazzani AA, Geng J, Genschik P, Gerner L, Gestwicki JE, Gewirtz DA, Ghavami S, Ghigo E, Ghosh D, Giammarioli AM, Giampieri F, Giampietri C, Giatromanolaki A, Gibbings DJ, Gibellini L, Gibson SB, Ginet V, Giordano A, Giorgini F, Giovannetti E, Girardin SE, Gispert S, Giuliano S, Gladson CL, Glavic A, Gleave M, Godefroy N, Gogal RM Jr, Gokulan K, Goldman GH, Goletti D, Goligorsky MS, Gomes AV, Gomes LC, Gomez H, Gomez-Manzano C, Gómez-Sánchez R, Gonçalves DA, Goncu E, Gong Q, Gongora C, Gonzalez CB, Gonzalez-Alegre P, Gonzalez-Cabo P, González-Polo RA, Goping IS, Gorbea C, Gorbunov NV, Goring DR, Gorman AM, Gorski SM, Goruppi S, Goto-Yamada S, Gotor C, Gottlieb RA, Gozes I, Gozuacik D, Graba Y, Graef M, Granato GE, Grant GD, Grant S, Gravina GL, Green DR, Greenhough A, Greenwood MT, Grimaldi B, Gros F, Grose C, Groulx JF, Gruber F, Grumati P, Grune T, Guan JL, Guan KL, Guerra B, Guillen C, Gulshan K, Gunst J, Guo C, Guo L, Guo M, Guo W, Guo XG, Gust AA, Gustafsson ÅB, Gutierrez E, Gutierrez MG, Gwak HS, Haas A, Haber JE, Hadano S, Hagedorn M, Hahn DR, Halayko AJ, Hamacher-Brady A, Hamada K, Hamai A, Hamann A, Hamasaki M, Hamer I, Hamid Q, Hammond EM, Han F, Han W, Handa JT, Hanover JA, Hansen M, Harada M, Harhaji-Trajkovic L, Harper JW, Harrath AH, Harris AL, Harris J, Hasler U, Hasselblatt P, Hasui K, Hawley RG, Hawley TS, He C, He CY, He F, He G, He RR, He XH, He YW, He YY, Heath JK, Hébert MJ, Heinzen RA, Helgason GV, Hensel M, Henske EP, Her C, Herman PK, Hernández A, Hernandez C, Hernández-Tiedra S, Hetz C, Hiesinger PR, Higaki K, Hilfiker S, Hill BG, Hill JA, Hill WD, Hino K, Hofius D, Hofman P, Höglinger GU, Höhfeld J, Holz MK, Hong Y, Hood DA, Hoozemans JJ, Hoppe T, Hsu C, Hsu CY, Hsu LC, Hu D, Hu G, Hu HM, Hu H, Hu MC, Hu YC, Hu ZW, Hua F, Hua Y, Huang C, Huang HL, Huang KH, Huang KY, Huang S, Huang S, Huang WP, Huang YR, Huang Y, Huang Y, Huber TB, Huebbe P, Huh WK, Hulmi JJ, Hur GM, Hurley JH, Husak Z, Hussain SN, Hussain S, Hwang JJ, Hwang S, Hwang TI, Ichihara A, Imai Y, Imbriano C, Inomata M, Into T, Iovane V, Iovanna JL, Iozzo RV, Ip NY, Irazoqui JE, Iribarren P, Isaka Y, Isakovic AJ, Ischiropoulos H, Isenberg JS, Ishaq M, Ishida H, Ishii I, Ishmael JE, Isidoro C, Isobe K, Isono E, Issazadeh-Navikas S, Itahana K, Itakura E, Ivanov AI, Iyer AK, Izquierdo JM, Izumi Y, Izzo V, Jäättelä M, Jaber N, Jackson DJ, Jackson WT, Jacob TG, Jacques TS, Jagannath C, Jain A, Jana NR, Jang BK, Jani A, Janji B, Jannig PR, Jansson PJ, Jean S, Jendrach M, Jeon JH, Jessen N, Jeung EB, Jia K, Jia L, Jiang H, Jiang H, Jiang L, Jiang T, Jiang X, Jiang X, Jiang X, Jiang Y, Jiang Y, Jiménez A, Jin C, Jin H, Jin L, Jin M, Jin S, Jinwal UK, Jo EK, Johansen T, Johnson DE, Johnson GV, Johnson JD, Jonasch E, Jones C, Joosten LA, Jordan J, Joseph AM, Joseph B, Joubert AM, Ju D, Ju J, Juan HF, Juenemann K, Juhász G, Jung HS, Jung JU, Jung YK, Jungbluth H, Justice MJ, Jutten B, Kaakoush NO, Kaarniranta K, Kaasik A, Kabuta T, Kaeffer B, Kågedal K, Kahana A, Kajimura S, Kakhlon O, Kalia M, Kalvakolanu DV, Kamada Y, Kambas K, Kaminskyy VO, Kampinga HH, Kandouz M, Kang C, Kang R, Kang TC, Kanki T, Kanneganti TD, Kanno H, Kanthasamy AG, Kantorow M, Kaparakis-Liaskos M, Kapuy O, Karantza V, Karim MR, Karmakar P, Kaser A, Kaushik S, Kawula T, Kaynar AM, Ke PY, Ke ZJ, Kehrl JH, Keller KE, Kemper JK, Kenworthy AK, Kepp O, Kern A, Kesari S, Kessel D, Ketteler R, Kettelhut Ido C, Khambu B, Khan MM, Khandelwal VK, Khare S, Kiang JG, Kiger AA, Kihara A, Kim AL, Kim CH, Kim DR, Kim DH, Kim EK, Kim HY, Kim HR, Kim JS, Kim JH, Kim JC, Kim JH, Kim KW, Kim MD, Kim MM, Kim PK, Kim SW, Kim SY, Kim YS, Kim Y, Kimchi A, Kimmelman AC, Kimura T, King JS, Kirkegaard K, Kirkin V, Kirshenbaum LA, Kishi S, Kitajima Y, Kitamoto K, Kitaoka Y, Kitazato K, Kley RA, Klimecki WT, Klinkenberg M, Klucken J, Knævelsrud H, Knecht E, Knuppertz L, Ko JL, Kobayashi S, Koch JC, Koechlin-Ramonatxo C, Koenig U, Koh YH, Köhler K, Kohlwein SD, Koike M, Komatsu M, Kominami E, Kong D, Kong HJ, Konstantakou EG, Kopp BT, Korcsmaros T, Korhonen L, Korolchuk VI, Koshkina NV, Kou Y, Koukourakis MI, Koumenis C, Kovács AL, Kovács T, Kovacs WJ, Koya D, Kraft C, Krainc D, Kramer H, Kravic-Stevovic T, Krek W, Kretz-Remy C, Krick R, Krishnamurthy M, Kriston-Vizi J, Kroemer G, Kruer MC, Kruger R, Ktistakis NT, Kuchitsu K, Kuhn C, Kumar AP, Kumar A, Kumar A, Kumar D, Kumar D, Kumar R, Kumar S, Kundu M, Kung HJ, Kuno A, Kuo SH, Kuret J, Kurz T, Kwok T, Kwon TK, Kwon YT, Kyrmizi I, La Spada AR, Lafont F, Lahm T, Lakkaraju A, Lam T, Lamark T, Lancel S, Landowski TH, Lane DJ, Lane JD, Lanzi C, Lapaquette P, Lapierre LR, Laporte J, Laukkarinen J, Laurie GW, Lavandero S, Lavie L, LaVoie MJ, Law BY, Law HK, Law KB, Layfield R, Lazo PA, Le Cam L, Le Roch KG, Le Stunff H, Leardkamolkarn V, Lecuit M, Lee BH, Lee CH, Lee EF, Lee GM, Lee HJ, Lee H, Lee JK, Lee J, Lee JH, Lee JH, Lee M, Lee MS, Lee PJ, Lee SW, Lee SJ, Lee SJ, Lee SY, Lee SH, Lee SS, Lee SJ, Lee S, Lee YR, Lee YJ, Lee YH, Leeuwenburgh C, Lefort S, Legouis R, Lei J, Lei QY, Leib DA, Leibowitz G, Lekli I, Lemaire SD, Lemasters JJ, Lemberg MK, Lemoine A, Leng S, Lenz G, Lenzi P, Lerman LO, Lettieri Barbato D, Leu JI, Leung HY, Levine B, Lewis PA, Lezoualc'h F, Li C, Li F, Li FJ, Li J, Li K, Li L, 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Stepkowski TM, Stern ST, Stevens C, Stockwell BR, Stoka V, Storchova Z, Stork B, Stratoulias V, Stravopodis DJ, Strnad P, Strohecker AM, Ström AL, Stromhaug P, Stulik J, Su YX, Su Z, Subauste CS, Subramaniam S, Sue CM, Suh SW, Sui X, Sukseree S, Sulzer D, Sun FL, Sun J, Sun J, Sun SY, Sun Y, Sun Y, Sun Y, Sundaramoorthy V, Sung J, Suzuki H, Suzuki K, Suzuki N, Suzuki T, Suzuki YJ, Swanson MS, Swanton C, Swärd K, Swarup G, Sweeney ST, Sylvester PW, Szatmari Z, Szegezdi E, Szlosarek PW, Taegtmeyer H, Tafani M, Taillebourg E, Tait SW, Takacs-Vellai K, Takahashi Y, Takáts S, Takemura G, Takigawa N, Talbot NJ, Tamagno E, Tamburini J, Tan CP, Tan L, Tan ML, Tan M, Tan YJ, Tanaka K, Tanaka M, Tang D, Tang D, Tang G, Tanida I, Tanji K, Tannous BA, Tapia JA, Tasset-Cuevas I, Tatar M, Tavassoly I, Tavernarakis N, Taylor A, Taylor GS, Taylor GA, Taylor JP, Taylor MJ, Tchetina EV, Tee AR, Teixeira-Clerc F, Telang S, Tencomnao T, Teng BB, Teng RJ, Terro F, Tettamanti G, Theiss AL, Theron AE, Thomas 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Weyand CM, White AR, White E, Whitton JL, Whitworth AJ, Wiels J, Wild F, Wildenberg ME, Wileman T, Wilkinson DS, Wilkinson S, Willbold D, Williams C, Williams K, Williamson PR, Winklhofer KF, Witkin SS, Wohlgemuth SE, Wollert T, Wolvetang EJ, Wong E, Wong GW, Wong RW, Wong VK, Woodcock EA, Wright KL, Wu C, Wu D, Wu GS, Wu J, Wu J, Wu M, Wu M, Wu S, Wu WK, Wu Y, Wu Z, Xavier CP, Xavier RJ, Xia GX, Xia T, Xia W, Xia Y, Xiao H, Xiao J, Xiao S, Xiao W, Xie CM, Xie Z, Xie Z, Xilouri M, Xiong Y, Xu C, Xu C, Xu F, Xu H, Xu H, Xu J, Xu J, Xu J, Xu L, Xu X, Xu Y, Xu Y, Xu ZX, Xu Z, Xue Y, Yamada T, Yamamoto A, Yamanaka K, Yamashina S, Yamashiro S, Yan B, Yan B, Yan X, Yan Z, Yanagi Y, Yang DS, Yang JM, Yang L, Yang M, Yang PM, Yang P, Yang Q, Yang W, Yang WY, Yang X, Yang Y, Yang Y, Yang Z, Yang Z, Yao MC, Yao PJ, Yao X, Yao Z, Yao Z, Yasui LS, Ye M, Yedvobnick B, Yeganeh B, Yeh ES, Yeyati PL, Yi F, Yi L, Yin XM, Yip CK, Yoo YM, Yoo YH, Yoon SY, Yoshida K, Yoshimori T, Young KH, Yu H, Yu JJ, Yu JT, Yu J, Yu L, Yu WH, Yu XF, Yu Z, Yuan J, Yuan ZM, Yue BY, Yue J, Yue Z, Zacks DN, Zacksenhaus E, Zaffaroni N, Zaglia T, Zakeri Z, Zecchini V, Zeng J, Zeng M, Zeng Q, Zervos AS, Zhang DD, Zhang F, Zhang G, Zhang GC, Zhang H, Zhang H, Zhang H, Zhang H, Zhang J, Zhang J, Zhang J, Zhang J, Zhang JP, Zhang L, Zhang L, Zhang L, Zhang L, Zhang MY, Zhang X, Zhang XD, Zhang Y, Zhang Y, Zhang Y, Zhang Y, Zhang Y, Zhao M, Zhao WL, Zhao X, Zhao YG, Zhao Y, Zhao Y, Zhao YX, Zhao Z, Zhao ZJ, Zheng D, Zheng XL, Zheng X, Zhivotovsky B, Zhong Q, Zhou GZ, Zhou G, Zhou H, Zhou SF, Zhou XJ, Zhu H, Zhu H, Zhu WG, Zhu W, Zhu XF, Zhu Y, Zhuang SM, Zhuang X, Ziparo E, Zois CE, Zoladek T, Zong WX, Zorzano A, Zughaier SM. Autophagy. 2016. PMID: 26799652.", + "Fructose levels are markedly elevated in cerebrospinal fluid compared to plasma in pregnant women. Hwang JJ, Johnson A, Cline G, Belfort-DeAguiar R, Snegovskikh D, Khokhar B, Han CS, Sherwin RS. PLoS One. 2015; 2015 Jun 2. PMID: 26035307.", + "Imaging human brown adipose tissue under room temperature conditions with (11)C-MRB, a selective norepinephrine transporter PET ligand. Hwang JJ, Yeckel CW, Gallezot JD, Aguiar RB, Ersahin D, Gao H, Kapinos M, Nabulsi N, Huang Y, Cheng D, Carson RE, Sherwin R, Ding YS. Metabolism. 2015 Jun; 2015 Mar 5. PMID: 25798999.", + "Treatment of endocrine disorders in the neuroscience intensive care unit. Hwang JJ, Hwang DY. Curr Treat Options Neurol. 2014 Feb. PMID: 24390813.", + "Electrical characterization of metal-molecule-silicon junctions. Wang W, Lee T, Kamdar M, Reed MA, Stewart MP, Hwang JJ, Tour JM. Ann N Y Acad Sci. 2003 Dec. PMID: 14976008.", + "", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Improving Pediatric Acute Care Through Simulation", + "lab_url": "https://medicine.yale.edu/lab/impacts/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Insogna Lab", + "lab_url": "https://medicine.yale.edu/lab/insogna/", + "research_bio": "INFORMATION FOR The Insogna research program has three components: translational, clinical, and analytical clinical research. The research team includes Ben-Hua Sun, Meiling Zhu, Gang-Qing Yao, and Edwin Siu. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/insogna/publications/", + "publications": null + }, + { + "lab_name": "InSTRIDE", + "lab_url": "https://medicine.yale.edu/lab/springer/", + "research_bio": "INFORMATION FOR OurMISSIONat InSTRIDE focuses on the intersection of substance use and infectious diseases. Current research focuses on treatments for opioid use disorder, specifically among persons with HIV and other infections, and the criminal justice population. Our mission is to improve the lives of persons with substance use disorder through both research and connecting people to community resources. Copy Link As a Board-Certified Internal Medicine, Infectious Disease and Addiction Medicine Physician, Dr. Sandra Springer formed the InSTRIDE Research Lab in 2018 to implement formative research at the intersection of infectious disease and substance use disorders. Since 2005, Springer has consistently been funded by the NIH to conduct various trials. Currently, she has five grants including a NIDA Avant Garde award funded in 2022. This award led Springer to push for the legalization of mobile retail pharmacies in the state of Connecticut. Springer’s dedication and tireless efforts eventually led to securing the FIRST in the country. Read more about all of Dr. Springer’s projects. 877-55-HELPU 833-MEDSVAN", + "publications_page": "https://medicine.yale.edu/lab/springer/publications/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Infectious Diseases /", + "Research", + "Community Resources", + "Publications More Publications", + "More Publications", + "Educational Information", + "People", + "In the News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Home", + "Publications", + "More Publications", + "", + "", + "", + "", + "", + "", + "Comprehensive Needs Among Justice-Involved People With Substance Use History With or at Risk of Human Immunodeficiency Virus. Choi JH, Patil S, Brooks R, Hansen L, Pulitzer Z, Pankow J, Colon R, Frank C, Proffitt R, Kuo I, Knight K, Springer SA, Nijhawan AE. J Correct Health Care. 2025 Oct; 2025 Sep 16. PMID: 40955746.", + "Medications for opioid use disorder shape immune responses during chronic HIV infection. Collora JA, Steinhauser SF, Davenport TC, Lin DC, Eshetu A, Zeidi S, Kim R, Frank C, Kluger Y, Springer SA, Ho YC. Cell Rep Med. 2025 Jun 17; 2025 Jun 2. PMID: 40460829.", + "Information Needs for Opioid Use Disorder Treatment Using Buprenorphine Product: Qualitative Analysis of Suboxone-Focused Reddit Data. Basak M, Sharif O, Lord SE, Borodovsky JT, Marsch LA, Springer SA, Nunes EV, Brackett CD, Archibald LJ, Preum SM. J Med Internet Res. 2025 Jun 9; 2025 Jun 9. PMID: 40489766.", + "A qualitative examination of barriers and facilitators to HIV prevention and treatment for people involved with the criminal justice system. Villaire S, Sease T, Pankow J, Bennett A, Pulitzer Z, Hansen L, Frank C, Di Paola A, Lehman W, Sanchez M, McQuaid A, Schultheis A, Stein B, Springer SA, Nijhawan AE, Knight K. Health Justice. 2025 Jun 6; 2025 Jun 6. PMID: 40478391.", + "Initiating Injectable Buprenorphine in People Hospitalized With Infections: A Randomized Clinical Trial. Seval N, Roth P, Frank CA, Di Paola A, Litwin AH, Vander Wyk B, Neirinckx V, Schlossberg E, Lawson P, Strong M, Schade MA, Nunez J, Levin FR, Brady KT, Nunes EV, Springer SA. JAMA Netw Open. 2025 May 1; 2025 May 1. PMID: 40445619.", + "Pilot Findings From the First Legalized Mobile Retail Pharmacy Clinic in the United States for Infectious Disease Treatment and Prevention Tailored to Reach People Who Use Drugs. Tarfa A, Di Paola A, Frank CA, Schultheis AM, Brooks R, Shenoi SV, Springer SA. Open Forum Infect Dis. 2025 Apr; 2025 Apr 24. PMID: 40276721.", + "Antiretroviral Drugs for Treatment and Prevention of HIV in Adults: 2024 Recommendations of the International Antiviral Society-USA Panel. Gandhi RT, Landovitz RJ, Sax PE, Smith DM, Springer SA, Günthard HF, Thompson MA, Bedimo RJ, Benson CA, Buchbinder SP, Crabtree-Ramirez BE, Del Rio C, Eaton EF, Eron JJ Jr, Hoy JF, Lehmann C, Molina JM, Jacobsen DM, Saag MS. JAMA. 2025 Feb 18. PMID: 39616604.", + "Commentary on Gregory et al.: Fear of precipitated opioid withdrawal should not prevent buprenorphine initiation. Springer SA. Addiction. 2025 Jan; 2024 Nov 4. PMID: 39494653.", + "Plans to end HIV should address substance use. Springer SA. Lancet HIV. 2024 Dec. PMID: 39632048.", + "Underuse of Lifesaving Medications for Opioid Use Disorder in US Jails. Springer SA. JAMA Netw Open. 2024 Sep 3; 2024 Sep 3. PMID: 39316405.", + "HIV and Substance Use Disorders. Lier AJ, Tarfa A, Shenoi SV, Kuo I, Springer SA. Infect Dis Clin North Am. 2024 Sep; 2024 Jul 2. PMID: 38960783.", + "Perspectives on benefits and risks of creation of an \"injection drug use\" billing code. Sundaram G, Sato T, Goodman-Meza D, Haddad M, Thakarar K, Feinberg J, Springer SA, Barton K, Butler N, Eaton EF, Wurcel AG. J Subst Use Addict Treat. 2024 Sep; 2024 May 10. PMID: 38735482.", + "Missed Opportunities for Preexposure Prophylaxis Initiation in Hospitalized Persons With Opioid Use Disorder and Infectious Diseases. Parchinski K, Neirinckx V, Frank C, Di Paola A, Tarfa A, Shenoi S, Vander Wyk B, Roth P, Ghantous T, Wegman MK, Strong M, Levin FR, Brady K, Nunes E, Litwin AH, Springer SA. Open Forum Infect Dis. 2024 Jul; 2024 Jul 10. PMID: 39022389.", + "Serious Opioid Injection-Related Infection and Initiation of Medication for Opioid Use Disorder. Springer SA. JAMA Netw Open. 2024 Jul 1; 2024 Jul 1. PMID: 39046746.", + "Considerations when prescribing opioid agonist therapies for people living with HIV. Tarfa A, Lier AJ, Shenoi SV, Springer SA. Expert Rev Clin Pharmacol. 2024 Jul; 2024 Jul 4. PMID: 38946101.", + "Validation of Two Diagnostic Assessments for Opioid and Stimulant Use Disorder for Use by Non-Clinicians. Di Paola A, Farabee D, Springer SA. Psychiatr Res Clin Pract. 2023 Fall; 2023 Aug 15. PMID: 37711754.", + "Integrated Care Models: HIV and Substance Use. Hill K, Kuo I, Shenoi SV, Desruisseaux MS, Springer SA. Curr HIV/AIDS Rep. 2023 Oct; 2023 Sep 12. PMID: 37698755.", + "Ending the HIV Epidemic for Persons Who Use Drugs: the Practical Challenges of Meeting People Where They Are. Springer SA. J Gen Intern Med. 2023 Sep; 2023 Mar 31. PMID: 37002460.", + "Inpatient Low-dose Transitions From Full Agonist Opioids Including Methadone Onto Long-acting Depot Buprenorphine: Case Series From a Multicenter Clinical Trial. Seval N, Nunez J, Roth P, Schade M, Strong M, Frank CA, Litwin AH, Levin FR, Brady KT, Nunes EV, Springer SA. J Addict Med. 2023 Jul-Aug 01; 2023 Jan 26. PMID: 37579095.", + "Corrigendum to 'Maintenance on extended-release naltrexone is associated with reduced injection opioid use among justice-involved persons with opioid use disorder' [J. Subst. Abuse Treat. vol. 142 (2022)/108852]. Lier AJ, Seval N, Vander Wyk B, Di Paola A, Springer SA. J Subst Use Addict Treat. 2023 Jul; 2023 Jun 3. PMID: 37271717.", + "The relationship between reincarceration and treatment of opioid use disorder with extended-release naltrexone among persons with HIV. Parchinski K, Di Paola A, Wilson AP, Springer SA. Drug Alcohol Depend Rep. 2023 Jun; 2023 Apr 14. PMID: 37159815.", + "Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2022 Recommendations of the International Antiviral Society-USA Panel. Gandhi RT, Bedimo R, Hoy JF, Landovitz RJ, Smith DM, Eaton EF, Lehmann C, Springer SA, Sax PE, Thompson MA, Benson CA, Buchbinder SP, Del Rio C, Eron JJ Jr, Günthard HF, Molina JM, Jacobsen DM, Saag MS. JAMA. 2023 Jan 3. PMID: 36454551.", + "The impact of COVID-19 on the treatment of opioid use disorder in carceral facilities: a cross-sectional study. Saunders EC, Satcher MF, Monico LB, McDonald RD, Springer SA, Farabee D, Gryczynski J, Nyaku A, Reeves D, Kunkel LE, Schultheis AM, Schwartz RP, Lee JD, Marsch LA, Waddell EN. Health Justice. 2022 Dec 19; 2022 Dec 19. PMID: 36529829.", + "Evaluation of the Impact of HIV Serostatus on the Hepatitis C Virus Care Cascade and Injection Drug Use Among Persons Initiating Medication Treatment for Opioid Use Disorder. Lier AJ, Vander Wyk B, Di Paola A, Springer SA. Open Forum Infect Dis. 2022 Nov; 2022 Nov 14. PMID: 36467300.", + "Maintenance on extended-release naltrexone is associated with reduced injection opioid use among justice-involved persons with opioid use disorder. Lier AJ, Seval N, Vander Wyk B, Di Paola A, Springer SA. J Subst Abuse Treat. 2022 Nov; 2022 Jul 30. PMID: 35988513.", + "Gender differences among persons entering medication treatment for opioid use disorder in the community. Di Paola A, Taweh N, Biondi BE, Forray A, Frank CA, Shaw A, Springer SA. Am J Addict. 2022 Sep; 2022 Jun 2. PMID: 35652902.", + "Study protocol of a randomized controlled trial comparing two linkage models for HIV prevention and treatment in justice-involved persons. Springer SA, Nijhawan AE, Knight K, Kuo I, Di Paola A, Schlossberg E, Frank CA, Sanchez M, Pankow J, Proffitt RP, Lehman W, Pulitzer Z, Thompson K, Violette S, Harding KK. BMC Infect Dis. 2022 Apr 15; 2022 Apr 15. PMID: 35428213.", + "Factors associated with retention on medications for opioid use disorder among a cohort of adults seeking treatment in the community. Biondi BE, Vander Wyk B, Schlossberg EF, Shaw A, Springer SA. Addict Sci Clin Pract. 2022 Mar 7; 2022 Mar 7. PMID: 35255967.", + "Commentary on Murphy et al.: What will it take to prescribe extended-release naltrexone to treat alcohol use disorder? Springer SA. Addiction. 2022 Feb; 2021 Sep 22. PMID: 34549844.", + "Rationale, design and methods of VA-BRAVE: a randomized comparative effectiveness trial of two formulations of buprenorphine for treatment of opioid use disorder in veterans. Petrakis I, Springer SA, Davis C, Ralevski E, Gu L, Lew R, Hermos J, Nuite M, Gordon AJ, Kosten TR, Nunes EV, Rosenheck R, Saxon AJ, Swift R, Goldberg A, Ringer R, Ferguson R. Addict Sci Clin Pract. 2022 Jan 31; 2022 Jan 31. PMID: 35101115.", + "Design and implementation of a cohort study of persons living with HIV infection who are initiating medication treatment for opioid use disorder to evaluate HIV-1 persistence. Schultheis A, Sanchez M, Pedersen S, Kyriakides T, Ho YC, Kluger Y, Springer SA. Contemp Clin Trials Commun. 2021 Dec; 2021 Nov 11. PMID: 34825103.", + "Feasibility of a community-based delivery model for HIV pre-exposure prophylaxis among bar patrons in rural South Africa. Grammatico MA, Moll AP, Choi K, Springer SA, Shenoi SV. J Int AIDS Soc. 2021 Nov. PMID: 34826363.", + "Linking criminal justice-involved individuals to HIV, Hepatitis C, and opioid use disorder prevention and treatment services upon release to the community: Progress, gaps, and future directions. Taweh N, Schlossberg E, Frank C, Nijhawan A, Kuo I, Knight K, Springer SA. Int J Drug Policy. 2021 Oct; 2021 May 18. PMID: 34020864.", + "A Systematic Review and Meta-Analysis of Studies Evaluating the Effect of Medication Treatment for Opioid Use Disorder on Infectious Disease Outcomes. McNamara KF, Biondi BE, Hernández-Ramírez RU, Taweh N, Grimshaw AA, Springer SA. Open Forum Infect Dis. 2021 Aug; 2021 Jun 2. PMID: 34430670.", + "Design and methods of a multi-site randomized controlled trial of an integrated care model of long-acting injectable buprenorphine with infectious disease treatment among persons hospitalized with infections and opioid use disorder. Seval N, Frank CA, Litwin AH, Roth P, Schade MA, Pavlicova M, Levin FR, Brady KT, Nunes EV, Springer SA. Contemp Clin Trials. 2021 Jun; 2021 Apr 7. PMID: 33838307.", + "Hepatitis C in the United States: One Step Forward, Two Steps Back. Rio CD, Springer SA. Am J Public Health. 2021 May. PMID: 33826392.", + "Design and implementation of a prospective cohort study of persons living with and without HIV infection who are initiating medication treatment for opioid use disorder. Biondi BE, Mohanty S, Wyk BV, Montgomery RR, Shaw AC, Springer SA. Contemp Clin Trials Commun. 2021 Mar; 2021 Jan 6. PMID: 33490708.", + "Gender differences among criminal justice-involved persons living with HIV interested in extended-release naltrexone treatment. Biondi BE, Frank CA, Forray A, Springer SA. Subst Abus. 2021; 2021 Mar 22. PMID: 33750285.", + "A systematic review of patients' and providers' perspectives of medications for treatment of opioid use disorder. Cioe K, Biondi BE, Easly R, Simard A, Zheng X, Springer SA. J Subst Abuse Treat. 2020 Dec; 2020 Sep 22. PMID: 33138929.", + "Preventing HIV outbreaks among people who inject drugs in the United States: plus ça change, plus ça même chose. Strathdee SA, Kuo I, El-Bassel N, Hodder S, Smith LR, Springer SA. AIDS. 2020 Nov 15. PMID: 32826391.", + "Do I Have HIV or Not? Lack of RNA Detection and the Case for Sensitive DNA Testing. Springer SA, Masciotra S, Johnson JA, Campbell S. Open Forum Infect Dis. 2020 Nov; 2020 Oct 10. PMID: 33204760.", + "Co-located Opioid Use Disorder and Hepatitis C Virus Treatment Is Not Only Right, But It Is Also the Smart Thing To Do as It Improves Outcomes! Springer SA, Del Rio C. Clin Infect Dis. 2020 Oct 23. PMID: 32011653.", + "Federal and State Action Needed to End the Infectious Complications of Illicit Drug Use in the United States: IDSA and HIVMA's Advocacy Agenda. Springer SA, Barocas JA, Wurcel A, Nijhawan A, Thakarar K, Lynfield R, Hurley H, Snowden J, Thornton A, Del Rio C. J Infect Dis. 2020 Sep 2. PMID: 32877568.", + "Addressing the Intersection of Infectious Disease Epidemics and Opioid and Substance Use Epidemics. Springer SA, Del Rio C. Infect Dis Clin North Am. 2020 Sep. PMID: 32782107.", + "Lessons Learned from the Response to the Human Immunodeficiency Virus Epidemic that Can Inform Addressing the Opioid Epidemic. Springer SA, Rio CD. Infect Dis Clin North Am. 2020 Sep. PMID: 32782106.", + "The Impact of Medications for Opioid Use Disorder on Hepatitis C Incidence Among Incarcerated Persons: A Systematic Review. Seval N, Wurcel A, Gunderson CG, Grimshaw A, Springer SA. Infect Dis Clin North Am. 2020 Sep. PMID: 32782102.", + "A Call to Action to Combat the Opioid Epidemic Among Women. Springer SA, Biondi BE, Frank C, El-Bassel N. J Addict Med. 2020 Sep/Oct. PMID: 32011410.", + "Aortic Valve Surgery Outcomes Reporting and Implications for Persons Who Use Drugs With Infectious Endocarditis. Springer SA. Clin Infect Dis. 2020 Jul 27. PMID: 31588502.", + "Integrating Responses to the Opioid Use Disorder and Infectious Disease Epidemics: A Report From the National Academies of Sciences, Engineering, and Medicine. Springer SA, Merluzzi AP, Del Rio C. JAMA. 2020 Jul 7. PMID: 32159771.", + "A Literature Review Examining Primary Outcomes of Medication Treatment Studies for Opioid Use Disorder: What Outcome Should Be Used to Measure Opioid Treatment Success? Biondi BE, Zheng X, Frank CA, Petrakis I, Springer SA. Am J Addict. 2020 Jul; 2020 Apr 29. PMID: 32346932.", + "Hepatitis C Virus Reinfection Rate Among Persons Who Use Drugs and Are Maintained on Medication Treatment for Opioid Use Disorder. Springer SA. Clin Infect Dis. 2020 Jun 10. PMID: 31346595.", + "Pregnancy, Substance Use, and Research: How do We Protect Women While Increasing Their Participation in Research? Biondi BE, Frank C, Springer SA. J Addict Med. 2020 May/Jun. PMID: 31403523.", + "Infectious Complications of Addiction: A Call for a New Subspecialty Within Infectious Diseases. Serota DP, Barocas JA, Springer SA. Clin Infect Dis. 2020 Feb 14. PMID: 31420651.", + "Beyond Antibiotics: A Practical Guide for the Infectious Disease Physician to Treat Opioid Use Disorder in the Setting of Associated Infectious Diseases. Seval N, Eaton E, Springer SA. Open Forum Infect Dis. 2020 Jan; 2019 Dec 24. PMID: 31993454.", + "Self-reported antiretroviral therapy adherence and viral load in criminal justice-involved populations. Cunningham WE, Nance RM, Golin CE, Flynn P, Knight K, Beckwith CG, Kuo I, Spaulding A, Taxman FS, Altice F, Delaney JA, Crane HM, Springer SA. BMC Infect Dis. 2019 Oct 29; 2019 Oct 29. PMID: 31664910.", + "Reduced Sexual Risk Behaviors Among Persons With HIV After Release From the Criminal Justice System. Biondi BE, Frank C, Horn BP, Springer SA. Open Forum Infect Dis. 2019 Oct; 2019 Sep 21. PMID: 31660369.", + "Treating opioid dependence with extended-release naltrexone (XR-NTX) in Ukraine: Feasibility and three-month outcomes. Makarenko I, Pykalo I, Springer SA, Mazhnaya A, Marcus R, Filippovich S, Dvoriak S, Altice FL. J Subst Abuse Treat. 2019 Sep; 2019 May 10. PMID: 31370983.", + "Actions to Integrate Treatment of Opioid and Infectious Disease Epidemics. Springer SA, Korthuis PT, Del Rio C. Ann Intern Med. 2019 Apr 2. PMID: 30934074.", + "Medications for Treatment of Opioid Use Disorder among Persons Living with HIV. Fanucchi L, Springer SA, Korthuis PT. Curr HIV/AIDS Rep. 2019 Feb. PMID: 30684117.", + "Approaches for creating comparable measures of alcohol use symptoms: Harmonization with eight studies of criminal justice populations. Hussong AM, Gottfredson NC, Bauer DJ, Curran PJ, Haroon M, Chandler R, Kahana SY, Delaney JAC, Altice FL, Beckwith CG, Feaster DJ, Flynn PM, Gordon MS, Knight K, Kuo I, Ouellet LJ, Quan VM, Seal DW, Springer SA. Drug Alcohol Depend. 2019 Jan 1; 2018 Oct 23. PMID: 30412898.", + "Integrating Treatment at the Intersection of Opioid Use Disorder and Infectious Disease Epidemics in Medical Settings: A Call for Action After a National Academies of Sciences, Engineering, and Medicine Workshop. Springer SA, Korthuis PT, Del Rio C. Ann Intern Med. 2018 Sep 4; 2018 Jul 13. PMID: 30007032.", + "Extended-release Naltrexone Improves Viral Suppression Among Incarcerated Persons Living with HIV and Alcohol use Disorders Transitioning to the Community: Results From a Double-Blind, Placebo-Controlled Trial. Springer SA, Di Paola A, Barbour R, Azar MM, Altice FL. J Acquir Immune Defic Syndr. 2018 Sep 1. PMID: 29781884.", + "Prevalence, Diagnosis, and Treatment Rates of Mood Disorders among Opioid Users under Criminal Justice Supervision. Mbaba M, Brown SE, Wooditch A, Kiss M, Murphy A, Kumari S, Taxman F, Altice F, Lawson WB, Springer SA. Subst Use Misuse. 2018 Jul 29; 2018 Jan 15. PMID: 29333954.", + "Risk behaviors and HIV care continuum outcomes among criminal justice-involved HIV-infected transgender women and cisgender men: Data from the Seek, Test, Treat, and Retain Harmonization Initiative. Beckwith CG, Kuo I, Fredericksen RJ, Brinkley-Rubinstein L, Cunningham WE, Springer SA, Loeliger KB, Franks J, Christopoulos K, Lorvick J, Kahana SY, Young R, Seal DW, Zawitz C, Delaney JA, Crane HM, Biggs ML. PLoS One. 2018; 2018 May 22. PMID: 29787580.", + "Extended-Release Naltrexone Improves Viral Suppression Among Incarcerated Persons Living With HIV With Opioid Use Disorders Transitioning to the Community: Results of a Double-Blind, Placebo-Controlled Randomized Trial. Springer SA, Di Paola A, Azar MM, Barbour R, Biondi BE, Desabrais M, Lincoln T, Skiest DJ, Altice FL. J Acquir Immune Defic Syndr. 2018 May 1. PMID: 29373393.", + "A qualitative assessment of attitudes about and preferences for extended-release naltrexone, a new pharmacotherapy to treat opioid use disorders in Ukraine. Marcus R, Bojko MJ, Mazhnaya A, Makarenko I, Filippovych S, Dvoriak S, Altice FL, Springer SA. J Subst Abuse Treat. 2018 Mar; 2018 Jan 5. PMID: 29415856.", + "Patient preferences and extended-release naltrexone: A new opportunity to treat opioid use disorders in Ukraine. Marcus R, Makarenko I, Mazhnaya A, Zelenev A, Polonsky M, Madden L, Filippovych S, Dvoriak S, Springer SA, Altice FL. Drug Alcohol Depend. 2017 Oct 1; 2017 Aug 5. PMID: 28806638.", + "Gender Differences in HIV Risk Behaviors Among Persons Involved in the U.S. Criminal Justice System and Living with HIV or at Risk for HIV: A \"Seek, Test, Treat, and Retain\" Harmonization Consortium. Loeliger KB, Biggs ML, Young R, Seal DW, Beckwith CG, Kuo I, Gordon MS, Altice FL, Ouellet LJ, Cunningham WE, Young JD, Springer SA. AIDS Behav. 2017 Oct. PMID: 28188460.", + "Corrigendum to 'An evaluation of hepatic enzyme elevations among HIV-infected released prisoners enrolled in two randomized placebo-controlled trials of extended release naltrexone' [Journal of Substance Abuse Treatment 47 (2014) 35-40]. Vagenas P, Di Paola A, Herme M, Lincoln T, Skiest DJ, Altice FL, Springer SA. J Subst Abuse Treat. 2017 Jun; 2017 Mar 18. PMID: 28476270.", + "Corrigendum to \"Design and methods of a double blind randomized placebo-controlled trial of extended-release naltrexone for alcohol dependent and hazardous drinking prisoners with HIV who are transitioning to the community\" [Contemp. Clin. Trials (2014) 209-218]. Springer SA, Altice FL, Herme M, Di Paola A. Contemp Clin Trials. 2017 Jun; 2017 Mar 21. PMID: 28341227.", + "Cohort profile: seek, test, treat and retain United States criminal justice cohort. Chandler R, Gordon MS, Kruszka B, Strand LN, Altice FL, Beckwith CG, Biggs ML, Cunningham W, Chris Delaney JA, Flynn PM, Golin CE, Knight K, Kral AH, Kuo I, Lorvick J, Nance RM, Ouellet LJ, Rich JD, Sacks S, Seal D, Spaulding A, Springer SA, Taxman F, Wohl D, Young JD, Young R, Crane HM. Subst Abuse Treat Prev Policy. 2017 May 16; 2017 May 16. PMID: 28511680.", + "Extended-release naltrexone reduces alcohol consumption among released prisoners with HIV disease as they transition to the community. Springer SA, Di Paola A, Azar MM, Barbour R, Krishnan A, Altice FL. Drug Alcohol Depend. 2017 May 1; 2017 Mar 10. PMID: 28334661.", + "An exploratory study of therapeutic misconception among incarcerated clinical trial participants. Christopher PP, Stein MD, Springer SA, Rich JD, Johnson JE, Lidz CW. AJOB Empir Bioeth. 2016; 2015 Jun 24. PMID: 26709382.", + "HIV-infected men who have sex with men, before and after release from jail: the impact of age and race, results from a multi-site study. Vagenas P, Zelenev A, Altice FL, Di Paola A, Jordan AO, Teixeira PA, Frew PM, Spaulding AC, Springer SA. AIDS Care. 2016; 2015 Aug 14. PMID: 26275122.", + "Correlates of retention on extended-release naltrexone among persons living with HIV infection transitioning to the community from the criminal justice system. Springer SA, Brown SE, Di Paola A, Altice FL. Drug Alcohol Depend. 2015 Dec 1; 2015 Oct 28. PMID: 26560326.", + "The Impact of Alcohol Use and Related Disorders on the HIV Continuum of Care: a Systematic Review : Alcohol and the HIV Continuum of Care. Vagenas P, Azar MM, Copenhaver MM, Springer SA, Molina PE, Altice FL. Curr HIV/AIDS Rep. 2015 Dec. PMID: 26412084.", + "Drug Treatment as HIV Prevention Among Women and Girls Who Inject Drugs From a Global Perspective: Progress, Gaps, and Future Directions. Springer SA, Larney S, Alam-Mehrjerdi Z, Altice FL, Metzger D, Shoptaw S. J Acquir Immune Defic Syndr. 2015 Jun 1. PMID: 25978482.", + "Prevalence and Predictors of Mental/Emotional Distress Among HIV+ Jail Detainees at Enrollment in an Observational Study. Lincoln T, Simon-Levine D, Smith J, Donenberg GR, Springer SA, Zaller N, Altice FL, Moore K, Jordan AO, Draine J, Desabrais M. J Correct Health Care. 2015 Apr. PMID: 25788608.", + "Validation of a Brief Measure of Opioid Dependence: The Rapid Opioid Dependence Screen (RODS). Wickersham JA, Azar MM, Cannon CM, Altice FL, Springer SA. J Correct Health Care. 2015 Jan. PMID: 25559628.", + "HIV in people reincarcerated in Connecticut prisons and jails: an observational cohort study. Meyer JP, Cepeda J, Springer SA, Wu J, Trestman RL, Altice FL. Lancet HIV. 2014 Nov 1. PMID: 25473651.", + "Design and methods of a double blind randomized placebo-controlled trial of extended-release naltrexone for HIV-infected, opioid dependent prisoners and jail detainees who are transitioning to the community. Di Paola A, Lincoln T, Skiest DJ, Desabrais M, Altice FL, Springer SA. Contemp Clin Trials. 2014 Nov; 2014 Sep 18. PMID: 25240704.", + "A comparison of psychiatric diagnoses among HIV-infected prisoners receiving combination antiretroviral therapy and transitioning to the community. Di Paola A, Altice FL, Powell ML, Trestman RL, Springer SA. Health Justice. 2014 Oct 29. PMID: 25606368.", + "An evaluation of hepatic enzyme elevations among HIV-infected released prisoners enrolled in two randomized placebo-controlled trials of extended release naltrexone. Vagenas P, Di Paola A, Herme M, Lincoln T, Skiest DJ, Altice FL, Springer SA. J Subst Abuse Treat. 2014 Jul; 2014 Mar 12. PMID: 24674234.", + "Optimization of human immunodeficiency virus treatment during incarceration: viral suppression at the prison gate. Meyer JP, Cepeda J, Wu J, Trestman RL, Altice FL, Springer SA. JAMA Intern Med. 2014 May. PMID: 24687044.", + "Design and methods of a double blind randomized placebo-controlled trial of extended-release naltrexone for alcohol dependent and hazardous drinking prisoners with HIV who are transitioning to the community. Springer SA, Altice FL, Herme M, Di Paola A. Contemp Clin Trials. 2014 Mar; 2013 Dec 31. PMID: 24384538.", + "Contribution of substance use disorders on HIV treatment outcomes and antiretroviral medication adherence among HIV-infected persons entering jail. Chitsaz E, Meyer JP, Krishnan A, Springer SA, Marcus R, Zaller N, Jordan AO, Lincoln T, Flanigan TP, Porterfield J, Altice FL. AIDS Behav. 2013 Oct. PMID: 23673792.", + "Post-release substance abuse outcomes among HIV-infected jail detainees: results from a multisite study. Krishnan A, Wickersham JA, Chitsaz E, Springer SA, Jordan AO, Zaller N, Altice FL. AIDS Behav. 2013 Oct. PMID: 23142854.", + "The impact of DSM-IV mental disorders on adherence to combination antiretroviral therapy among adult persons living with HIV/AIDS: a systematic review. Springer SA, Dushaj A, Azar MM. AIDS Behav. 2012 Nov. PMID: 22644066.", + "Rationale, study design and sample characteristics of a randomized controlled trial of directly administered antiretroviral therapy for HIV-infected prisoners transitioning to the community - a potential conduit to improved HIV treatment outcomes. Saber-Tehrani AS, Springer SA, Qiu J, Herme M, Wickersham J, Altice FL. Contemp Clin Trials. 2012 Mar; 2011 Nov 12. PMID: 22101218.", + "High rates of depressive symptomatology among injecting drug users in Saskatoon, Canada. Springer SA. Evid Based Ment Health. 2012 Feb; 2011 Nov 1. PMID: 22044870.", + "Retention on buprenorphine is associated with high levels of maximal viral suppression among HIV-infected opioid dependent released prisoners. Springer SA, Qiu J, Saber-Tehrani AS, Altice FL. PLoS One. 2012; 2012 May 31. PMID: 22719814.", + "Public health implications for adequate transitional care for HIV-infected prisoners: five essential components. Springer SA, Spaulding AC, Meyer JP, Altice FL. Clin Infect Dis. 2011 Sep. PMID: 21844030.", + "Substance abuse, violence, and HIV in women: a literature review of the syndemic. Meyer JP, Springer SA, Altice FL. J Womens Health (Larchmt). 2011 Jul; 2011 Jun 13. PMID: 21668380.", + "Advances in the prevention of heterosexual transmission of HIV/AIDS among women in the United States. Chen NE, Meyer JP, Springer SA. Infect Dis Rep. 2011 Jan 1. PMID: 23745166.", + "HIV Treatment in the Criminal Justice System: Critical Knowledge and Intervention Gaps. Meyer JP, Chen NE, Springer SA. AIDS Res Treat. 2011; 2011 Jul 12. PMID: 21776379.", + "HIV, alcohol dependence, and the criminal justice system: a review and call for evidence-based treatment for released prisoners. Springer SA, Azar MM, Altice FL. Am J Drug Alcohol Abuse. 2011 Jan; 2010 Dec 21. PMID: 21171933.", + "A systematic review of the impact of alcohol use disorders on HIV treatment outcomes, adherence to antiretroviral therapy and health care utilization. Azar MM, Springer SA, Meyer JP, Altice FL. Drug Alcohol Depend. 2010 Dec 1; 2010 Aug 11. PMID: 20705402.", + "Neurocognitive impairment and HIV risk factors: a reciprocal relationship. Anand P, Springer SA, Copenhaver MM, Altice FL. AIDS Behav. 2010 Dec. PMID: 20232242.", + "Improved HIV and substance abuse treatment outcomes for released HIV-infected prisoners: the impact of buprenorphine treatment. Springer SA, Chen S, Altice FL. J Urban Health. 2010 Jul. PMID: 20177974.", + "Commentary on Larney (2010): a call to action-opioid substitution therapy as a conduit to routine care and primary prevention of HIV transmission among opioid-dependent prisoners. Springer SA. Addiction. 2010 Feb. PMID: 20078481.", + "Maps & Directions", + "Contact Us", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Ishibe Lab", + "lab_url": "https://medicine.yale.edu/lab/ishibe/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/ishibe/publications/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Nephrology /", + "Research", + "Contact", + "Members Lab Alumni", + "Lab Alumni", + "Lab Life", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Members", + "Lab Life", + "Publications", + "Contact", + "", + "", + "", + "", + "", + "", + "A T Cell Intrinsic Role for APOL1 Risk Alleles in Allograft Rejection Pell J , Tanvir E, Sun Z, Reghuvaran A , Guerra M, Mizuno H, Kumar A, Zhang W, Azzi J, Murakami N, Ishibe S , Heeger P, Menon M . A T Cell Intrinsic Role for APOL1 Risk Alleles in Allograft Rejection . American Journal Of Transplantation 2025, 25: s91-s92. DOI: 10.1016/j.ajt.2025.07.188 . Peer-Reviewed Original Research", + "GIT ArfGAP2: A Cytoskeletal Safeguard in Podocytes Ishibe S , Tian X . GIT ArfGAP2: A Cytoskeletal Safeguard in Podocytes . Journal Of The American Society Of Nephrology 2025, 36: 1005-1007. PMID: 40257840 , PMCID: PMC12147969 , DOI: 10.1681/asn.0000000707 . Commentaries, Editorials and Letters Altmetric", + "Editorial: Case reports in nephrology Tian X , Ardiles L, Block C. Editorial: Case reports in nephrology . Frontiers In Nephrology 2025, 5: 1595978. PMID: 40260144 , PMCID: PMC12009917 , DOI: 10.3389/fneph.2025.1595978 . Commentaries, Editorials and Letters Altmetric", + "CRB2 depletion induces YAP signaling and disrupts mechanosensing in podocytes Sun Y, Kronenberg N, Sethi S, Dash S, Kovalik M, Sempowski B, Strickland S, Raina R, Sperati C, Tian X , Ishibe S , Hall G, Gather M. CRB2 depletion induces YAP signaling and disrupts mechanosensing in podocytes . American Journal Of Physiology. Renal Physiology 2025, 328: f578-f595. PMID: 40062402 , PMCID: PMC12076484 , DOI: 10.1152/ajprenal.00318.2024 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Adaptor Proteins, Signal Transducing Animals Carrier Proteins Female Glomerulosclerosis, Focal Segmental Humans Male Mechanotransduction, Cellular Membrane Proteins Mutation Pedigree Podocytes Transcription Factors YAP-Signaling Proteins Concepts Substrate stiffness-dependent manner Yes-Associated Protein Elastic Resonator Interference Stress Microscopy Crumbs homolog 2 Increasing substrate stiffness Stiffness-dependent manner Substrate stiffness Knockdown cells Density of focal adhesions Compound heterozygous mutations Homolog 2 Truncating mutation p. Low substrate stiffness Yes-associated protein signaling Heterozygous mutations Yes-associated protein transcriptional activity Target gene expression Enhanced cell contractility Focal adhesions Truncated p. Knockdown effect F-actin Transcriptional activity YAP activity Pathogenic mutations", + "Efficacy and Safety of Belimumab in Severe Lupus Nephritis: A Retrospective Single-Center Study Aierken A, Zhuang J, Yang S, Yalikun D, Xu C, Zhang C, Tian X , Jiang H. Efficacy and Safety of Belimumab in Severe Lupus Nephritis: A Retrospective Single-Center Study . Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.202486qykah2. DOI: 10.1681/asn.202486qykah2 . Peer-Reviewed Original Research", + "Atypical Hemolytic Uremic Syndrome with Peripheral Gangrene Aierken A, Muhetaer G, Yang S, Zhuang J, Jiang H, Tian X . Atypical Hemolytic Uremic Syndrome with Peripheral Gangrene . Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.20244hj831a8. DOI: 10.1681/asn.20244hj831a8 . Peer-Reviewed Original Research", + "Podocytic Infolding Glomerulopathy: A Systematic Report of 44 Cases Shen Z, Zhang C, Zhuang J, Qu Y, Tian X , Jiang H. Podocytic Infolding Glomerulopathy: A Systematic Report of 44 Cases . Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024y382k1hb. DOI: 10.1681/asn.2024y382k1hb . Peer-Reviewed Original Research", + "Preventing MMP23-mediated cleavage of podocyte RARRES1: a novel strategy to halt chronic kidney disease progression? Medina Rangel P, Ishibe S . Preventing MMP23-mediated cleavage of podocyte RARRES1: a novel strategy to halt chronic kidney disease progression? Kidney International 2024, 106: 16-18. PMID: 38906649 , DOI: 10.1016/j.kint.2024.05.004 . Peer-Reviewed Original Research Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Cell Line Disease Progression Humans Kidney Tubules, Proximal Mice Podocytes Proteolysis Renal Insufficiency, Chronic Concepts Protein 1 Matrix metalloproteases Proximal tubular cells Tubular cells", + "Fallopian tube wrapping as a cause of catheter malfunction in peritoneal dialysis: a report of two cases and management strategies Chen X, Chen Z, Du Y, Tian X , Fu R. Fallopian tube wrapping as a cause of catheter malfunction in peritoneal dialysis: a report of two cases and management strategies . AME Case Reports 2024, 0: 0-0. PMID: 39091550 , PMCID: PMC11292095 , DOI: 10.21037/acr-23-201 . Peer-Reviewed Original Research Citations Concepts Catheter malfunction Peritoneal dialysis Catheter function Female PD patients Catheter dysfunction Catheter fixation Utilization of laparoscopy PD patients Abdominal X-ray Intra-abdominal organs PD catheter Fallopian tube Potential causes Catheter displacement Catheter obstruction Catheter migration Catheter implantation Laparoscopic surgery Catheter insertion Favorable outcome Laparoscopic examination Omental wrapping Days post-implantation Catheter Catheter kinking", + "WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury Wang Y, Cui C, Zhao W, Tian X , Liu P, Wei L, Zhu Z, Liu M, Fu R, Jia L. WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury . Immunobiology 2024, 229: 152832. PMID: 38943814 , DOI: 10.1016/j.imbio.2024.152832 . Peer-Reviewed Original Research Citations Concepts Acute kidney injury Acute tubular injury LPS-induced acute kidney injury Human kidney 2 Wip1 activity Kidney injury Renal tubules Unilateral ischemia-reperfusion injury Sepsis-associated acute kidney injury Renal tubules of patients HK2 cells Protein levels Induce acute injury Proximal renal tubules Wild-type p53-induced phosphatase 1 Ischemia-reperfusion injury Phosphorylation of p38 MAPK GSDMD-N Human kidney-2 cells Single-cell sequencing PPM1D mRNA Phospho-p38 MAPK Tubular injury Wip1 inhibitor ScRNA-seq", + "Clinical Characteristics of 427 Unvaccinated Chinese Adult Patients with Maintenance Hemodialysis Infected with the SARS-CoV-2 Omicron Variant: A Retrospective Study Ha X, Zhao Z, Zhao T, Muhetaer G, Wang X, Bao A, Duan Y, Zhuang J, Song X, Zhou Y, Zhang Q, Wu J, Fan M, Zhang L, Tian X , Jiang H. Clinical Characteristics of 427 Unvaccinated Chinese Adult Patients with Maintenance Hemodialysis Infected with the SARS-CoV-2 Omicron Variant: A Retrospective Study . Integrative Medicine In Nephrology And Andrology 2024, 11: e23-00018. DOI: 10.1097/imna-d-23-00018 . Peer-Reviewed Original Research Citations Concepts SARS-CoV-2 Omicron infection Maintenance hemodialysis Clinical characteristics MHD patients SARS-CoV-2 Omicron variant SARS-CoV-2 Disease severity Follow-up Serum C-reactive protein levels Omicron infection Risk factors C-reactive protein levels Follow-up assessment Independent risk factor Spectrum of disease severity Chinese adult patients Tailored treatment strategies Negative nucleic acid Adult MHD patients Maintenance hemodialysis patients High-risk population Arterial oxygen partial pressure Omicron variant Procalcitonin levels Prognostic factors", + "ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging Jiang Q , Song G, He L, Li X, Jiang B, Wang Q, Wang S, Kim C, Barkestani M, Lopez R, Fan M, Wanniarachchi K, Quaranta M, Tian X , Mani A , Gonzalez A , Goodwin J, Sessa W , Ishibe S , Jane-Wit D. ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging . Kidney International 2024, 106: 419-432. PMID: 38797325 , PMCID: PMC11343665 , DOI: 10.1016/j.kint.2024.05.007 . Peer-Reviewed Original Research Citations Altmetric Concepts Vascular barrier function Endothelial cells Reduced endothelial nitric oxide Regulator of vascular barrier function Endothelial nitric oxide signaling ENOS activity Endosome-associated proteins Barrier function Kidney organ cultures Endothelial nitric oxide Akt-dependent manner Nitric oxide donor GTPase Rab5 Nitric Oxide Signaling ZFYVE21 Live cell imaging Kidney insufficiency Reporter mice Trafficking mechanisms Accelerated aging phenotype Knockout mice Interstitial edema Kidney function Vesicular population Oxide donor", + "Mediating role of social support in dysphoria, despondency, and quality of life in patients undergoing maintenance hemodialysis Zhou X, Jiang H, Zhou Y, Wang X, Ren H, Tian X , Zhang Q. Mediating role of social support in dysphoria, despondency, and quality of life in patients undergoing maintenance hemodialysis . World Journal Of Psychiatry 2024, 14: 409-420. PMID: 38617988 , PMCID: PMC11008395 , DOI: 10.5498/wjp.v14.i3.409 . Peer-Reviewed Original Research Citations Concepts Quality of life Social support Social Support Rating Scale Mental well-being of patients Levels of social support Overal quality of life Impact of social support Self-Rating Anxiety Scale Quality of Life Scale Self-rating Depression Scale Well-being of patients Self-ratings Mental Well-Being Quality of life of patients Depression Scale Effects of dysphoria Psychological issues Anxiety Scale Rating Scale Dysphoria Maintenance hemodialysis Mediation role Random sampling approach Support Despondency", + "DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways Li K, Zhang Y, Zhao W, Wang R, Li Y, Wei L, Wang L, Chen X, Chen Z, Liu P, Nie N, Tian X , Fu R. DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways . Toxicology Letters 2024, 395: 1-10. PMID: 38458339 , DOI: 10.1016/j.toxlet.2024.03.001 . Peer-Reviewed Original Research Citations Concepts Human mesangial cells Akt Signaling Pathway Extracellular matrix Signaling pathway Dipeptidyl peptidase IV Mesangial cells Expression of ECM-related proteins Phosphorylation of Akt ECM-related proteins Abnormal extracellular matrix ECM deposition Excessive deposition of extracellular matrix Phosphorylation of Smad2 DPP8/9 inhibition Deposition of extracellular matrix Glomerular mesangial cells DPP9 Collagen IV DPP8 Akt Multiple diseases DPP8/9 SiRNA Pathogenesis of glomerular disease Cells", + "A comparison of chemiluminescent immunoassay and enzyme-linked immunosorbent assay for detecting phospholipase A2 receptor antibody in primary membranous nephropathy Ma X, Wang R, Wei L, Liu P, Jing L, Wang J, Dong W, Tian X , Fu R. A comparison of chemiluminescent immunoassay and enzyme-linked immunosorbent assay for detecting phospholipase A2 receptor antibody in primary membranous nephropathy . Practical Laboratory Medicine 2024, 39: e00385. PMID: 38495349 , PMCID: PMC10940994 , DOI: 10.1016/j.plabm.2024.e00385 . Peer-Reviewed Original Research Citations Altmetric Concepts Anti-PLA2R antibodies Enzyme-linked immunosorbent assay Negative predictive value Positive predictive value Anti-PLA2R Membranous nephropathy Chemiluminescence immunoassay Levels of anti-PLA2R antibodies Phospholipase A2 receptor antibody Predictive value Primary membranous nephropathy Phospholipase A2 receptor Immunosorbent assay Results Serum levels Statistical analysis of sensitivity ROC curve analysis Non-membranous nephropathy Statistically significant difference PMN group Receptor antibodies Serum levels A2 receptors Spearman correlation analysis Diagnostic value Nephropathy", + "Clinical Characteristics and Outcomes of Unvaccinated Kidney Transplant Recipients Infected with the SARS-CoV-2 Omicron Variant: A Case Series Qu Y, Zhuang J, Duan Y, Baibutihan A, Maimaiti Z, Zhang C, Niu J, Teng W, Ailimu M, Wei X, Qi B, Li J, Du S, Wang D, Cao K, Wang J, Lu C, Tian X , Jiang H. Clinical Characteristics and Outcomes of Unvaccinated Kidney Transplant Recipients Infected with the SARS-CoV-2 Omicron Variant: A Case Series . Integrative Medicine In Nephrology And Andrology 2024, 11: e00019. DOI: 10.1097/imna-d-23-00019 . Peer-Reviewed Original Research Altmetric Concepts Kidney transplant recipients KT recipients Clinical characteristics Kidney transplantation Transplant recipients Elevated serum D-dimer Incidence of severe infections Omicron infection Severe/critical illness Outcomes of severe acute respiratory syndrome coronavirus 2 Calcineurin inhibitor drugs Serum D-dimer Serum albumin level SARS-CoV-2 Acute kidney injury Follow-up period C-reactive protein SARS-CoV-2 Omicron infection SARS-CoV-2 Omicron variant Reverse transcription polymerase chain reaction Immunocompromised status Ferritin levels Transcription polymerase chain reaction Severe/critical group Antiviral therapy", + "Editorial: Association between diabetic nephropathy and diabetic retinopathy or non-diabetic nephropathy Chen H, Tian X , Yu X. Editorial: Association between diabetic nephropathy and diabetic retinopathy or non-diabetic nephropathy . Frontiers In Endocrinology 2024, 15: 1359011. PMID: 38332890 , PMCID: PMC10852059 , DOI: 10.3389/fendo.2024.1359011 . Commentaries, Editorials and Letters Altmetric MeSH Keywords and Concepts MeSH Keywords Diabetes Mellitus, Type 2 Diabetic Nephropathies Diabetic Retinopathy Humans Concepts Non-diabetic nephropathy Diabetic retinopathy Diabetic nephropathy", + "Characteristics of renal pathology and coagulation function in IgA nephropathy and IgA vasculitis associated nephritis Wang Y, Wang H, Ma X, Zhu Z, Tian X , Fu R, Jia L. Characteristics of renal pathology and coagulation function in IgA nephropathy and IgA vasculitis associated nephritis . BMC Nephrology 2024, 25: 35. PMID: 38273279 , PMCID: PMC10811929 , DOI: 10.1186/s12882-024-03465-6 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Fibrinogen Glomerulonephritis, IGA Humans IgA Vasculitis Kidney Nephritis Retrospective Studies Concepts IgAN patients Fibrinogen degradation products IgA nephropathy IgAVN patients Levels of plasma D-dimer Levels of serum creatinine Partial remission rate Severe coagulation abnormalities Plasma D-dimer Poor renal function Chronic kidney injury Remission rate Pathological results Serum creatinine Abdominal symptoms Renal function Coagulation abnormalities Deposition of fibrinogen Kidney biopsy D-dimer Kidney injury Coagulation function IgAVN IgAN group MethodsA total", + "Understanding the podocyte immune responses in proteinuric kidney diseases: from pathogenesis to therapy Jiang H, Shen Z, Zhuang J, Lu C, Qu Y, Xu C, Yang S, Tian X . Understanding the podocyte immune responses in proteinuric kidney diseases: from pathogenesis to therapy . Frontiers In Immunology 2024, 14: 1335936. PMID: 38288116 , PMCID: PMC10822972 , DOI: 10.3389/fimmu.2023.1335936 . Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Endothelial Cells Glomerular Basement Membrane Humans Immunity Podocytes Renal Insufficiency, Chronic Concepts Chronic kidney disease Glomerular filtration barrier Proteinuric glomerular diseases Kidney disease Glomerular disease Immune response Filtration barrier Therapeutic target Cell-like characteristics Focal segmental glomerulosclerosis Proteinuric kidney disease Targets of immune responses Damage to podocytes Lupus nephritis Potential therapeutic target Glomerular basement membrane Immune injury Glomerular injury Membranous nephropathy Fenestrated endothelial cells Kidney function Segmental glomerulosclerosis Adaptive immunity Epithelial cells Pathogenic mechanisms", + "Successful outcome in a case of idiopathic multicentric Castleman disease with atypical lymphadenopathy and kidney injury: Diagnostic challenges and treatment approach—Case report Yalikun D, Zhuang J, Lei W, Wang C, Aierken A, Qu Y, Wang J, Tian X , Jiang H. Successful outcome in a case of idiopathic multicentric Castleman disease with atypical lymphadenopathy and kidney injury: Diagnostic challenges and treatment approach—Case report . SAGE Open Medical Case Reports 2024, 12: 2050313x241240097. PMID: 38559411 , PMCID: PMC10981217 , DOI: 10.1177/2050313x241240097 . Peer-Reviewed Case Reports and Technical Notes Citations Concepts Idiopathic multicentric Castleman disease Castleman's disease Multicentric Castleman's disease Significant lymphadenopathy Systemic inflammation Kidney injury Cases of idiopathic multicentric Castleman's disease Months of follow-up Lymph node biopsy Urinary tract infection Anti-infective treatment Patient's clinical symptoms Acute kidney injury No significant lymphadenopathy Loss of appetite Node biopsy Symptomatic recurrence Persistent fever Tract infections Multiorgan involvement Renal function Diagnostic challenge Inflammatory markers Case report Favorable outcome", + "Profilin1 is required to prevent mitotic catastrophe in murine and human glomerular diseases Tian X , Pedigo C, Li K, Ma X, Bunda P , Pell J , Lek A, Gu J , Zhang Y, Rangel P, Li W, Schwartze E, Nagata S, Lerner G, Perincheri S , Priyadarshini A, Zhao H , Lek M , Menon M , Fu R, Ishibe S . Profilin1 is required to prevent mitotic catastrophe in murine and human glomerular diseases . Journal Of Clinical Investigation 2023, 133: e171237. PMID: 37847555 , PMCID: PMC10721156 , DOI: 10.1172/jci171237 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Cell Cycle Proteins Cell Death Humans Kidney Diseases Kidney Glomerulus Mice Podocytes Profilins Proteinuria Concepts Proteinuric kidney disease Kidney disease Podocyte loss Human glomerular diseases Mitotic catastrophe Podocyte cell cycle Severe proteinuria Cell cycle reentry Kidney failure Glomerular disease Cell cycle Kidney tissue G1/S checkpoint Unsuccessful repair Cyclin D1 Glomerular integrity Irregular nuclei Tissue-specific loss Mouse podocytes Podocytes Altered expression Disease Cyclin B1 Ribosome affinity purification Multinucleated cells", + "Thrombotic Microangiopathy and Acute Tubular Injury After Diethylene Glycol Ingestion: A Kidney Biopsy Teaching Case Malvar G, Gunasekaran D, Mehr N, Ishibe S , Moeckel G . Thrombotic Microangiopathy and Acute Tubular Injury After Diethylene Glycol Ingestion: A Kidney Biopsy Teaching Case . Kidney Medicine 2023, 6: 100758. PMID: 38304581 , PMCID: PMC10831151 , DOI: 10.1016/j.xkme.2023.100758 . Peer-Reviewed Original Research Citations Concepts Acute tubular injury Thrombotic microangiopathy Tubular injury Endothelial injury Possible life-threatening complications Direct toxic injury Incidence of AKI Initial gastrointestinal symptoms Life-threatening complications Typical clinical course Diethylene glycol poisoning Peripheral sensorimotor neuropathy High mortality rate Diethylene glycol ingestion Gastrointestinal symptoms Clinical course Kidney biopsy Glycol ingestion Sensorimotor neuropathy Glycol poisoning Pathological lesions Toxic injury Genetic predisposition Unusual case Mortality rate", + "Uncovering the Role of Cyclin G-Associated Kinase (GAK) in Regulating the Podocyte Cytoskeleton Bunda P , Tian X , Inoue K, Ishibe S . Uncovering the Role of Cyclin G-Associated Kinase (GAK) in Regulating the Podocyte Cytoskeleton . Journal Of The American Society Of Nephrology 2023, 34: 302-303. DOI: 10.1681/asn.20233411s1302d . Peer-Reviewed Original Research", + "Thrombotic Microangiopathy from Chafing Fuel Intoxication Mehr N, Malvar G, Gunasekaran D, Ishibe S , Moeckel G . Thrombotic Microangiopathy from Chafing Fuel Intoxication . Journal Of The American Society Of Nephrology 2023, 34: 466-466. DOI: 10.1681/asn.20233411s1466d . Peer-Reviewed Original Research", + "IgG4-Related Disease with IgG1-Dominant Membranous Nephropathy: A Rare Case Report Duan Y, Qu Y, Zhuang J, Abudula R, Zhang C, Tian X , Jiang H. IgG4-Related Disease with IgG1-Dominant Membranous Nephropathy: A Rare Case Report . Integrative Medicine In Nephrology And Andrology 2023, 10: e00007. DOI: 10.1097/imna-d-23-00007 . Peer-Reviewed Case Reports and Technical Notes Citations Concepts Membranous nephropathy Clinical remission IgG4-RD Nephrotic syndrome IgG4-related tubulointerstitial nephritis Rare pathological feature Complete clinical remission Primary membranous nephropathy Rare case report Glucocorticoid therapy PLA2R staining Kidney involvement Maintenance therapy Rituximab treatment RTX treatment Immunoglobulin G4 Tubulointerstitial nephritis Kidney biopsy Subepithelial deposition Pathological features Case report Fibroinflammatory disorder Antigen staining Nephropathy Receptor antigen", + "Maps & Directions", + "4 Events you could attend in November 2025 Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Iwakiri Lab", + "lab_url": "https://medicine.yale.edu/lab/iwakiri/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/iwakiri/publications/", + "publications": null + }, + { + "lab_name": "Iwasaki Lab", + "lab_url": "https://medicine.yale.edu/lab/iwasaki/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "J. Meyer Lab", + "lab_url": "https://medicine.yale.edu/lab/jmeyer/", + "research_bio": "INFORMATION FOR Copy Link Our research centers on HIV and women’s health. We inform, develop and test HIV prevention and treatment interventions specific to women who are involved in criminal justice systems, women with substance use disorders, and women experiencing intimate partner violence. In doing so, we aim to develop interventions that address social determinants of health and are gender-responsive and trauma-informed. We apply principles of implementation science to adapt these interventions to key contexts, including criminal justice settings (prison, jail, probation, parole), drug treatment centers, and domestic violence service providers. Our work includes using patient-centered decision aids on HIV pre-exposure prophylaxis (PrEP) to help women make informed choices about HIV prevention, scaling up PrEP among key populations of women, and integrating housing and health services for people who are justice-involved. We strive to build programs for social justice, empowerment, and access to services to alleviate the burden of infectious diseases among key populations. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/jmeyer/publications", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Infectious Diseases /", + "Research and Projects", + "Lab Members Collaborators", + "Collaborators", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research and Projects", + "Lab Members", + "Publications", + "News", + "", + "", + "", + "", + "", + "", + "Exercise Interventions Conducted Among Individuals with Co-occurring HIV and Unhealthy Substance Use: A Systematic Review. Mistler CB, Allen W, Grimshaw AA, Idiong CI, Harsono D, Irwin ML, Ash G, S Pescatello L, Meyer JP, Jennifer Edelman E. AIDS Behav. 2025 Sep; 2025 Apr 28. PMID: 40289036.", + "Real-world Rollout of Injectable Antiretrovirals for HIV Prevention and Treatment: Correlates of Early Adoption. Koshy L, Payne E, Barakat L, Hao R, Sureshanand S, Cedillo Ornelas A, Dewan A, Meyer JP. Open Forum Infect Dis. 2025 Feb; 2025 Jan 20. PMID: 40207202.", + "Decarceration and COVID-19 infections in U.S. Immigration and Customs Enforcement detention facilities: a simulation modeling study. Weyant C, Meyer JP, Bromberg D, Beyrer C, Altice FL, Goldhaber-Fiebert JD. Lancet Reg Health Am. 2025 Feb; 2024 Dec 27. PMID: 39830893.", + "Rationale and design of a randomized clinical trial of integrated eHealth for PrEP and medications for opioid use disorders for women in the criminal legal system. The Athena study. Meyer JP, Brunson S, Price CR, Mulrain M, Nguyen J, Altice FL, Kyriakides TC, Cropsey K, Eaton E. Addict Sci Clin Pract. 2025 Jan 17; 2025 Jan 17. PMID: 39825419.", + "A PrEP decision aid for women survivors of intimate partner violence: Task-shifting implementation to domestic violence service settings. Meyer JP, Lazarus E, Phillips K, Watts ZT, Duroseau B, Carlson C, Price CR, Kershaw T, Willie TC. PLoS One. 2024; 2024 Sep 17. PMID: 39288155.", + "Impact of COVID-19 on women living with HIV who are survivors of intimate partner violence. Zhang X, Price CR, Pope AS, Sullivan TP, Meyer JP. BMC Public Health. 2024 May 20; 2024 May 20. PMID: 38769576.", + "National HIV and HCV Screening Rates for Hospitalized People who Use Drugs Are Suboptimal and Heterogeneous Across 11 US Hospitals. Westgard LK, Sato T, Bradford WS, Eaton EF, Pilcher F, Hale AJ, Singh D, Martin M, Appa AA, Meyer JP, Weimer MB, Barakat LA, Felsen UR, Akiyama MJ, Ridgway JP, Grussing ED, Thakarar K, White A, Mutelayi J, Krsak M, Montague BT, Nijhawan A, Balakrishnan H, Marks LR, Wurcel AG. Open Forum Infect Dis. 2024 May; 2024 Apr 16. PMID: 38746950.", + "Food Insecurity among Women Involved in the Criminal Legal System and Members of their Risk Network. Robles J, Kershaw T, Meyer JP. J Health Care Poor Underserved. 2024. PMID: 39584269.", + "Uptake of Cervical Cancer Screening Among Female Patients Using a Mobile Medical Clinic. Degife EA, Oliveira CR, Znamierowski E, Meyer JP, Sheth SS. Am J Prev Med. 2023 Nov; 2023 May 21. PMID: 37220860.", + "Building an Infectious Disease Diversity, Equity, and Antiracism (ID2EA) Curriculum: A Single Center's Experience and Reflections. Gleeson SE, Zapata H, Bathgate ME, Emu B, Frederick J, Friedland G, Golden MP, Meyer JP, Radin J, Sideleau R, Shaw A, Shenoi SV, Trubin PA, Virata M, Barakat LA, Desruisseaux MS. Clin Infect Dis. 2023 Sep 11. PMID: 37078888.", + "Correction to: Experiences with Telemedicine for HIV Care During the COVID-19 Pandemic: A Mixed-Methods Study. Harsono D, Deng Y, Chung S, Barakat LA, Friedland G, Meyer JP, Porter E, Villanueva M, Wolf MS, Yager JE, Edelman EJ. AIDS Behav. 2023 Jun. PMID: 36318433.", + "Experience delivering an integrated service model to people with criminal justice system involvement and housing insecurity. Baker O, Wellington C, Price CR, Tracey D, Powell L, Loffredo S, Moscariello S, Meyer JP. BMC Public Health. 2023 Feb 2; 2023 Feb 2. PMID: 36732685.", + "A PrEP Demonstration Project Using eHealth and Community Outreach to Justice-Involved Cisgender Women and Their Risk Networks. Meyer JP, Price CR, Ye Y, Qin Y, Tracey D, Demidont AC, Melbourne K, Altice FL. AIDS Behav. 2022 Dec; 2022 Jun 7. PMID: 35672552.", + "Interest without uptake: A mixed-methods analysis of methadone utilization in Kyrgyz prisons. Liberman AR, Bromberg DJ, Litz T, Kurmanalieva A, Galvez S, Rozanova J, Azbel L, Meyer JP, Altice FL. PLoS One. 2022; 2022 Oct 25. PMID: 36282864.", + "Willingness to Be Vaccinated Against COVID-19 Among People With HIV in the United States: Results From a National Survey. Wickersham JA, Meyer JP, Shenoi S, Altice FL, Barakat LA, Virata M, Olivares M, Maviglia F, Khati A, Shrestha R. Front Med (Lausanne). 2022; 2022 Jun 30. PMID: 35847816.", + "Experiences with Telemedicine for HIV Care During the COVID-19 Pandemic: A Mixed-Methods Study. Harsono D, Deng Y, Chung S, Barakat LA, Friedland G, Meyer JP, Porter E, Villanueva M, Wolf MS, Yager JE, Edelman EJ. AIDS Behav. 2022 Jun; 2022 Jan 22. PMID: 35064390.", + "COVID-19 Vaccine Hesitancy and Associated Factors among People with HIV in the United States: Findings from a National Survey. Shrestha R, Meyer JP, Shenoi S, Khati A, Altice FL, Mistler C, Aoun-Barakat L, Virata M, Olivares M, Wickersham JA. Vaccines (Basel). 2022 Mar 10; 2022 Mar 10. PMID: 35335054.", + "Meeting the Moment by Vaccinating Prison Staff Against COVID-19. Meyer JP, King J, Rosenberg A. JAMA Health Forum. 2022 Mar 1; 2022 Mar 1. PMID: 36218873.", + "Methadone within prison and linkage to and retention in treatment upon community release for people with opioid use disorder in Kyrgyzstan: Evaluation of a national program. Bachireddy C, Shrestha R, Bromberg DJ, Azbel L, Kurmanalieva A, Wegman M, Shumskaya N, Rozanova J, Meyer JP, Altice FL. Int J Drug Policy. 2022 Mar; 2021 Dec 13. PMID: 34915426.", + "Preexposure Prophylaxis for Women Across the Criminal Justice System: Implications for Policy and Practice. Hoff E, Rutledge R, Gibson BA, Price CR, Gallagher C, Maurer K, Meyer JP. J Correct Health Care. 2022 Feb; 2021 Nov 11. PMID: 34762498.", + "Overlapping needs for sexual and reproductive health and HIV prevention in women with substance use disorders. Gibson B, Hoff E, Haas A, Adams ZM, Price CR, Goddard-Eckrich D, Sheth SS, Dasgupta A, Meyer JP. Womens Health (Lond). 2022 Jan-Dec. PMID: 35023410.", + "\"A good mother\": Impact of motherhood identity on women's substance use and engagement in treatment across the lifespan. Adams ZM, Ginapp CM, Price CR, Qin Y, Madden LM, Yonkers K, Meyer JP. J Subst Abuse Treat. 2021 Nov; 2021 May 14. PMID: 34118710.", + "Progress and remaining challenges to address hepatitis C, other infectious diseases, and drug-related harms to improve the health of people who use drugs. Grebely J, Collins AB, Artenie AA, Sutherland R, Meyer JP, Barocas JA, Falade-Nwulia O, Cepeda JA, Cunningham EB, Hajarizadeh B, Lafferty L, Lazarus JV, Bonn M, Marshall AD, Treloar C. Int J Drug Policy. 2021 Oct; 2021 Oct 2. PMID: 34610884.", + "Differential impacts of COVID-19 across racial-ethnic identities in persons with opioid use disorder. Mistler CB, Sullivan MC, Copenhaver MM, Meyer JP, Roth AM, Shenoi SV, Edelman EJ, Wickersham JA, Shrestha R. J Subst Abuse Treat. 2021 Oct; 2021 Apr 8. PMID: 34080555.", + "Decisional considerations for methadone uptake in Kyrgyz prisons: The importance of understanding context and providing accurate information. Liberman AR, Bromberg DJ, Azbel L, Rozanova J, Madden L, Meyer JP, Altice FL. Int J Drug Policy. 2021 Aug; 2021 Apr 7. PMID: 33838398.", + "Women's Intersectional Risks for HIV and Incarceration and Implications for Interventions. Meyer JP. J Womens Health (Larchmt). 2021 May; 2020 Oct 30. PMID: 33124955.", + "Reproductive Life Goals: A Systematic Review of Pregnancy Planning Intentions, Needs, and Interventions Among Women Involved in U.S. Criminal Justice Systems. Hoff E, Adams ZM, Grimshaw A, Goddard-Eckrich DA, Dasgupta A, Sheth SS, Meyer JP. J Womens Health (Larchmt). 2021 Mar; 2020 Jun 23. PMID: 32589492.", + "A qualitative study of diphenhydramine injection in Kyrgyz prisons and implications for harm reduction. Meyer JP, Culbert GJ, Azbel L, Bachireddy C, Kurmanalieva A, Rhodes T, Altice FL. Harm Reduct J. 2020 Oct 31; 2020 Oct 31. PMID: 33129341.", + "Improving Health Equity for Women Involved in the Criminal Legal System. Golembeski CA, Sufrin CB, Williams B, Bedell PS, Glied SA, Binswanger IA, Hylton D, Winkelman TNA, Meyer JP. Womens Health Issues. 2020 Sep-Oct; 2020 Jul 29. PMID: 32739132.", + "COVID-19 and the coming epidemic in US immigration detention centres. Meyer JP, Franco-Paredes C, Parmar P, Yasin F, Gartland M. Lancet Infect Dis. 2020 Jun; 2020 Apr 15. PMID: 32304631.", + "Women's Decision-Making about PrEP for HIV Prevention in Drug Treatment Contexts. Qin Y, Price C, Rutledge R, Puglisi L, Madden LM, Meyer JP. J Int Assoc Provid AIDS Care. 2020 Jan-Dec. PMID: 31918605.", + "Depressive symptoms, physical symptoms, and health-related quality of life among older adults with HIV. Olson B, Vincent W, Meyer JP, Kershaw T, Sikkema KJ, Heckman TG, Hansen NB. Qual Life Res. 2019 Dec; 2019 Aug 24. PMID: 31446515.", + "The Sustained Harmful Health Effects of Incarceration for Women Living with HIV. Meyer JP. J Womens Health (Larchmt). 2019 Aug; 2019 Jul 29. PMID: 31355697.", + "Evaluation of HIV risk and outcomes in a nationally representative sample of incarcerated women in Azerbaijan, Kyrgyzstan, and Ukraine. Ranjit YS, Azbel L, Krishnan A, Altice FL, Meyer JP. AIDS Care. 2019 Jul; 2019 Jan 31. PMID: 30701981.", + "An event-level examination of successful condom negotiation strategies among young women. Peasant C, Montanaro EA, Kershaw TS, Parra GR, Weiss NH, Meyer JP, Murphy JG, Ritchwood TD, Sullivan TP. J Health Psychol. 2019 Jun; 2017 Feb 5. PMID: 28810400.", + "Research on women with substance use disorders: Reviewing progress and developing a research and implementation roadmap. Meyer JP, Isaacs K, El-Shahawy O, Burlew AK, Wechsberg W. Drug Alcohol Depend. 2019 Apr 1; 2019 Feb 21. PMID: 30826625.", + "All-cause mortality among people with HIV released from an integrated system of jails and prisons in Connecticut, USA, 2007-14: a retrospective observational cohort study. Loeliger KB, Altice FL, Ciarleglio MM, Rich KM, Chandra DK, Gallagher C, Desai MM, Meyer JP. Lancet HIV. 2018 Nov; 2018 Sep 6. PMID: 30197101.", + "Retention in HIV care during the 3 years following release from incarceration: A cohort study. Loeliger KB, Meyer JP, Desai MM, Ciarleglio MM, Gallagher C, Altice FL. PLoS Med. 2018 Oct; 2018 Oct 9. PMID: 30300351.", + "HIV Risk perception and eligibility for pre-exposure prophylaxis in women involved in the criminal justice system. Rutledge R, Madden L, Ogbuagu O, Meyer JP. AIDS Care. 2018 Oct; 2018 Mar 11. PMID: 29527934.", + "Words can hurt: The effects of physical and psychological partner violence on condom negotiation and condom use among young women. Peasant C, Sullivan TP, Ritchwood TD, Parra GR, Weiss NH, Meyer JP, Murphy JG. Women Health. 2018 May-Jun; 2017 Apr 28. PMID: 28402194.", + "Evaluating concurrent validity of criminal justice and clinical assessments among women on probation. Odio CD, Carroll M, Glass S, Bauman A, Taxman FS, Meyer JP. Health Justice. 2018 Apr 7; 2018 Apr 7. PMID: 29627964.", + "Predictors of linkage to HIV care and viral suppression after release from jails and prisons: a retrospective cohort study. Loeliger KB, Altice FL, Desai MM, Ciarleglio MM, Gallagher C, Meyer JP. Lancet HIV. 2018 Feb; 2017 Nov 27. PMID: 29191440.", + "Answer to December 2017 Photo Quiz. Bernardo R, Streiter S, Tiberio P, Rodwin BA, Mohareb A, Ogbuagu O, Emu B, Meyer JP. J Clin Microbiol. 2017 Dec. PMID: 29180506.", + "Photo Quiz: Peripheral Blood Smear in a Ugandan Refugee. Bernardo R, Streiter S, Tiberio P, Rodwin BA, Mohareb A, Ogbuagu O, Emu B, Meyer JP. J Clin Microbiol. 2017 Dec. PMID: 29180502.", + "The effects of opioid-agonist treatments on HIV risk and social stability: A mixed methods study of women with opioid use disorder in Ukraine. Hoff E, Marcus R, Bojko MJ, Makarenko I, Mazhnaya A, Altice FL, Meyer JP. J Subst Abuse Treat. 2017 Dec; 2017 Oct 12. PMID: 29129194.", + "Leveraging the U.S. Criminal Justice System to Access Women for HIV Interventions. Meyer JP, Muthulingam D, El-Bassel N, Altice FL. AIDS Behav. 2017 Dec. PMID: 28534199.", + "Prevalence of Human Immunodeficiency Virus and Sexually Transmitted Infections Among Cisgender and Transgender Women Sex Workers in Greater Kuala Lumpur, Malaysia: Results From a Respondent-Driven Sampling Study. Wickersham JA, Gibson BA, Bazazi AR, Pillai V, Pedersen CJ, Meyer JP, El-Bassel N, Mayer KH, Kamarulzaman A, Altice FL. Sex Transm Dis. 2017 Nov. PMID: 28708696.", + "Emerging role of Actinomyces meyeri in brain abscesses: A case report and literature review. Vazquez Guillamet LJ, Malinis MF, Meyer JP. IDCases. 2017; 2017 Jul 20. PMID: 28831384.", + "Correlates of willingness to initiate pre-exposure prophylaxis and anticipation of practicing safer drug- and sex-related behaviors among high-risk drug users on methadone treatment. Shrestha R, Karki P, Altice FL, Huedo-Medina TB, Meyer JP, Madden L, Copenhaver M. Drug Alcohol Depend. 2017 Apr 1; 2017 Feb 2. PMID: 28214391.", + "Beyond the syndemic: condom negotiation and use among women experiencing partner violence. Peasant C, Sullivan TP, Weiss NH, Martinez I, Meyer JP. AIDS Care. 2017 Apr; 2016 Sep 2. PMID: 27590004.", + "Beyond the Pap Smear: Gender-responsive HIV Care for Women. Meyer JP, Womack JA, Gibson B. Yale J Biol Med. 2016 Jun; 2016 Jun 27. PMID: 27354845.", + "Evidence-based interventions to enhance assessment, treatment, and adherence in the chronic Hepatitis C care continuum. Meyer JP, Moghimi Y, Marcus R, Lim JK, Litwin AH, Altice FL. Int J Drug Policy. 2015 Oct; 2015 May 17. PMID: 26077144.", + "Sex-Related Disparities in Criminal Justice and HIV Treatment Outcomes: A Retrospective Cohort Study of HIV-Infected Inmates. Meyer JP, Cepeda J, Taxman FS, Altice FL. Am J Public Health. 2015 Sep; 2015 Jul 16. PMID: 26180958.", + "Emergency department use among HIV-infected released jail detainees. Boyd AT, Song DL, Meyer JP, Altice FL. J Urban Health. 2015 Feb. PMID: 25331820.", + "Are Nectarines to Blame? A Case Report and Literature Review of Spontaneous Bacterial Peritonitis Due to Listeria monocytogenes. How J, Azar MM, Meyer JP. Conn Med. 2015 Jan. PMID: 25960571.", + "HIV in people reincarcerated in Connecticut prisons and jails: an observational cohort study. Meyer JP, Cepeda J, Springer SA, Wu J, Trestman RL, Altice FL. Lancet HIV. 2014 Nov 1. PMID: 25473651.", + "Capsule Commentary on Pyra et al., sexual minority status and violence among HIV infected and at-risk women. Meyer JP. J Gen Intern Med. 2014 Aug. PMID: 24793727.", + "Optimization of human immunodeficiency virus treatment during incarceration: viral suppression at the prison gate. Meyer JP, Cepeda J, Wu J, Trestman RL, Altice FL, Springer SA. JAMA Intern Med. 2014 May. PMID: 24687044.", + "Gender disparities in HIV treatment outcomes following release from jail: results from a multicenter study. Meyer JP, Zelenev A, Wickersham JA, Williams CT, Teixeira PA, Altice FL. Am J Public Health. 2014 Mar; 2014 Jan 16. PMID: 24432878.", + "Optimizing care for HIV-infected people who use drugs: evidence-based approaches to overcoming healthcare disparities. Meyer JP, Althoff AL, Altice FL. Clin Infect Dis. 2013 Nov; 2013 Jun 23. PMID: 23797288.", + "Contribution of substance use disorders on HIV treatment outcomes and antiretroviral medication adherence among HIV-infected persons entering jail. Chitsaz E, Meyer JP, Krishnan A, Springer SA, Marcus R, Zaller N, Jordan AO, Lincoln T, Flanigan TP, Porterfield J, Altice FL. AIDS Behav. 2013 Oct. PMID: 23673792.", + "Correlates of retention in HIV care after release from jail: results from a multi-site study. Althoff AL, Zelenev A, Meyer JP, Fu J, Brown SE, Vagenas P, Avery AK, Cruzado-Quiñones J, Spaulding AC, Altice FL. AIDS Behav. 2013 Oct. PMID: 23161210.", + "Adherence to HIV treatment and care among previously homeless jail detainees. Chen NE, Meyer JP, Avery AK, Draine J, Flanigan TP, Lincoln T, Spaulding AC, Springer SA, Altice FL. AIDS Behav. 2013 Oct. PMID: 22065234.", + "Partner violence and health among HIV-infected jail detainees. Meyer JP, Wickersham JA, Fu JJ, Brown SE, Sullivan TP, Springer SA, Altice FL. Int J Prison Health. 2013. PMID: 24376468.", + "Frequent emergency department use among released prisoners with human immunodeficiency virus: characterization including a novel multimorbidity index. Meyer JP, Qiu J, Chen NE, Larkin GL, Altice FL. Acad Emerg Med. 2013 Jan. PMID: 23570481.", + "HIV testing behaviors among Latinos in Baltimore City. Chen NE, Meyer JP, Bollinger R, Page KR. J Immigr Minor Health. 2012 Aug. PMID: 22262410.", + "Emergency department use by released prisoners with HIV: an observational longitudinal study. Meyer JP, Qiu J, Chen NE, Larkin GL, Altice FL. PLoS One. 2012; 2012 Aug 3. PMID: 22879972.", + "Public health implications for adequate transitional care for HIV-infected prisoners: five essential components. Springer SA, Spaulding AC, Meyer JP, Altice FL. Clin Infect Dis. 2011 Sep. PMID: 21844030.", + "Substance abuse, violence, and HIV in women: a literature review of the syndemic. Meyer JP, Springer SA, Altice FL. J Womens Health (Larchmt). 2011 Jul; 2011 Jun 13. PMID: 21668380.", + "Advances in the prevention of heterosexual transmission of HIV/AIDS among women in the United States. Chen NE, Meyer JP, Springer SA. Infect Dis Rep. 2011 Jan 1. PMID: 23745166.", + "HIV Treatment in the Criminal Justice System: Critical Knowledge and Intervention Gaps. Meyer JP, Chen NE, Springer SA. AIDS Res Treat. 2011; 2011 Jul 12. PMID: 21776379.", + "A systematic review of the impact of alcohol use disorders on HIV treatment outcomes, adherence to antiretroviral therapy and health care utilization. Azar MM, Springer SA, Meyer JP, Altice FL. Drug Alcohol Depend. 2010 Dec 1; 2010 Aug 11. PMID: 20705402.", + "", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Jason L. Schwartz, Ph.D.", + "lab_url": "https://medicine.yale.edu/lab/jschwartz/", + "research_bio": "INFORMATION FOR Jason L. Schwartz is an Associate Professor in the Department of Health Policy and Management at the Yale School of Public Health. His research examines vaccines and vaccination policy, decision-making in medical regulation and public health policy, and the structure and function of scientific expert advice to government. The overall focus of his work is on the ways in which evidence is interpreted, evaluated, and translated into regulation and policy in medicine and public health. He holds a secondary appointment in the Section of the History of Medicine at the Yale School of Medicine and is also affiliated with Yale's Institution for Social and Policy Studies and Program in the History of Science and Medicine. Schwartz's publications have appeared inThe New England Journal of Medicine,The Journal of the American Medical Association (JAMA),The American Journal of Public Health,BMJ, The Lancet, Health Affairs, and elsewhere. He is also an author of the chapter titled “Ethics” inPlotkin's Vaccines, the leading textbook of vaccine science and policy, and editor ofVaccination Ethics and Policy: An Introduction with Readings. Among his current research projects is a book,Solicited Advice: Expert Committees, Government Health Agencies, and Medicine in Modern America,that examines the emergence, evolution, and continuing influence of expert advisory committees in American medicine and public health from the 1960s to the present, particularly regarding pharmaceuticals, vaccines, and screening technologies. This project is supported by the National Institutes of Health. Other ongoing projects examine how policy-makers, regulators, payers, physicians, and patients evaluate and respond to the risks, benefits, and costs of medical interventions. Schwartz regularly teaches courses and gives lectures on vaccination issues, health policy and the U.S. health care system, pharmaceuticals and the FDA, science advice to government, and related topics. His research, analysis, and perspectives have appeared in theNew York Times, Washington Post, CNN, NPR, BBC, Time, and elsewhere. He has testified before the U.S. House Oversight Subcommittee on Economic and Consumer Policy, the National Vaccine Advisory Committee, and the Presidential Commission for the Study of Bioethical Issues. He is an elected fellow of The Hastings Center and a member ofThe LancetCommission on Vaccine Acceptance in the United States, the New England Comparative Effectiveness Public Advisory Council for the Institute for Clinical and Economic Review (ICER), and the Board of Trustees of Saint Thomas More Catholic Chapel & Center at Yale. During the COVID-19 pandemic, Schwartz was a member of Connecticut Gov. Ned Lamont's COVID-19 Vaccine Advisory Group and chair of its Science Subcommittee. He also advised colleges and universities, K-12 schools, early childhood centers, churches, and other organizations regarding their COVID-19 policies and protocols, particularly with respect to vaccines. Prior to arriving at Yale, Schwartz was the Harold T. Shapiro Fellow at the Princeton University Center for Human Values, and earlier, an Associate Fellow and Lecturer in the Department of Medical Ethics and Health Policy at the University of Pennsylvania Perelman School of Medicine. He was also a staff member for President Barack Obama's Presidential Commission for the Study of Bioethical Issues, where he was a lead staff author of the Commission's 2010 report on synthetic biology and emerging technologies and a contributor to its 2011 investigation of U.S. Public Health Service-led STD research in Guatemala in the 1940s. Schwartz is a graduate of Princeton University, where he received an A.B. in classics, and the University of Pennsylvania, where he received a Ph.D. in the history and sociology of science and a master's degree (MBE) in bioethics. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/jschwartz/publications/", + "publications": [ + "Yale School of Public Health /", + "Health Policy & Management /", + "Research Interests", + "Publications", + "Teaching", + "Media", + "Prospective Students", + "Alumni", + "Donors", + "Employers", + "Academic Calendar", + "myYSPH Members", + "Support YSPH", + "Research Interests", + "Publications", + "Teaching", + "Media", + "", + "", + "", + "", + "", + "", + "Email jason.l.schwartz@yale.edu", + "Yale School of Public Health 60 College Street, Rm 312 New Haven, CT 06510", + "Calendar", + "Sterling Hall of Medicine 333 Cedar Street New Haven, CT 06520-8023", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Jenny Zhou Lab", + "lab_url": "https://medicine.yale.edu/lab/jenny-zhou/", + "research_bio": "INFORMATION FOR Dr. Zhou has focused on translational research from the very beginning of her postgraduate study. To discover the molecular mechanisms and facilitate new therapeutic strategies for vascular diseases, Dr. Zhou has worked on angiogenesis and lymphangiogenesis, predominantly to investigate the role of CCM3, Trx2, SENP1 and AIP1 genes in animal models and in vitro for vascular biology, cell biology and signaling, as well as potential therapeutic targets which would provide promising treatment for vascular diseases such as cerebral cavernous malformation, diabetic retinopathy and cardiomyopathy. We are open to highly motivated postgraduate students and postgraduates including visiting scholars who has MD degree, PhD degree/candidate, both MD and PhD degree/candidate, to work on exciting on-going directions, especially vascular biology and malformations, vascular diseases (CCM, AVM, Eye diseases and Lymphatic diseases) and translational perspectives. We prefer someone who is experienced in both in vivo and in vitro study. Pleasecontact Dr. Zhou directlywith your updated CV if you are interested. Copy Link In previous research, Dr. Zhou has: Copy Link This lab will continue to investigate the cardiovascular and retinal disease in the aspects of endothelial signaling and biology, vascular malformation and remodeling. The lab is conducting translational research in vascular biology with a focus on human vascular diseases like cerebral cavernous malformations (CCMs) and retinopathy. Our goal is to dissect the signaling pathways in endothelial cells involved in vascular development, remodeling and disease progression. We will use mouse genetic models, in vitro biochemical and cell biological approaches to define the critical molecules mediating vascular development and pathogenesis, to verify the signaling in human disease samples, and to identify therapeutic targets for human vascular diseases. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/jenny-zhou/publications", + "publications": [ + "Yale School of Medicine /", + "Pathology /", + "Ongoing Projects", + "Lab Members", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Ongoing Projects", + "Lab Members", + "Publications", + "", + "", + "", + "", + "", + "", + "Correction: Endothelial AIP1 regulates vascular remodeling by suppressing NADPH Oxidase-2. Zhang J, Chen C, Li L, Zhou HJ, Li F, Zhang H, Yu L, Chen Y, Min W. Front Physiol. 2025; 2025 Aug 4. PMID: 40832137.", + "Corrigendum to \"Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome\" [Journal of Molecular and Cellular Cardiology 138 (2020) 291-303]. Yang B, Huang Y, Zhang H, Huang Y, Zhou HJ, Young L, Xiao H, Min W. J Mol Cell Cardiol. 2025 Aug; 2025 Jul 2. PMID: 40609213.", + "Author Correction: Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model. Zhou HJ, Qin L, Jiang Q, Murray KN, Zhang H, Li B, Lin Q, Graham M, Liu X, Grutzendler J, Min W. Nat Commun. 2025 Jul 10; 2025 Jul 10. PMID: 40640167.", + "Author Correction: SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression. Shao L, Zhou HJ, Zhang H, Qin L, Hwa J, Yun Z, Ji W, Min W. Nat Commun. 2025 Jun 23; 2025 Jun 23. PMID: 40550826.", + "Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance. He F, Huang Y, Song Z, Zhou HJ, Zhang H, Perry RJ, Shulman GI, Min W. J Exp Med. 2021 Mar 1. PMID: 33315085.", + "Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model. Zhou HJ, Qin L, Jiang Q, Murray KN, Zhang H, Li B, Lin Q, Graham M, Liu X, Grutzendler J, Min W. Nat Commun. 2021 Jan 25; 2021 Jan 25. PMID: 33495460.", + "ATPIF1 maintains normal mitochondrial structure which is impaired by CCM3 deficiency in endothelial cells. Wang K, Chen H, Zhou Z, Zhang H, Zhou HJ, Min W. Cell Biosci. 2021 Jan 9; 2021 Jan 9. PMID: 33422124.", + "Mural Cell-Specific Deletion of Cerebral Cavernous Malformation 3 in the Brain Induces Cerebral Cavernous Malformations. Wang K, Zhang H, He Y, Jiang Q, Tanaka Y, Park IH, Pober JS, Min W, Zhou HJ. Arterioscler Thromb Vasc Biol. 2020 Sep; 2020 Jul 9. PMID: 32640906.", + "BMX Represses Thrombin-PAR1-Mediated Endothelial Permeability and Vascular Leakage During Early Sepsis. Li Z, Yin M, Zhang H, Ni W, Pierce RW, Zhou HJ, Min W. Circ Res. 2020 Feb 14; 2020 Jan 8. PMID: 31910739.", + "Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome. Yang B, Huang Y, Zhang H, Huang Y, Zhou HJ, Young L, Xiao H, Min W. J Mol Cell Cardiol. 2020 Jan; 2019 Nov 18. PMID: 31751569.", + "Nuclear localization of the tyrosine kinase BMX mediates VEGFR2 expression. Liu T, Li Y, Su H, Zhang H, Jones D, Zhou HJ, Ji W, Min W. J Cell Mol Med. 2020 Jan; 2019 Oct 23. PMID: 31642192.", + "Short AIP1 (ASK1-Interacting Protein-1) Isoform Localizes to the Mitochondria and Promotes Vascular Dysfunction. Li Z, Li L, Zhang H, Zhou HJ, Ji W, Min W. Arterioscler Thromb Vasc Biol. 2020 Jan; 2019 Oct 17. PMID: 31619063.", + "A Unique SUMO-Interacting Motif of Trx2 Is Critical for Its Mitochondrial Presequence Processing and Anti-oxidant Activity. Chen C, Wang K, Zhang H, Zhou HJ, Chen Y, Min W. Front Physiol. 2019; 2019 Aug 27. PMID: 31555141.", + "Author Correction: SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis. Zhou HJ, Xu Z, Wang Z, Zhang H, Zhuang ZW, Simons M, Min W. Nat Commun. 2019 Aug 15; 2019 Aug 15. PMID: 31417083.", + "CCM3 and cerebral cavernous malformation disease. Wang K, Zhou HJ, Wang M. Stroke Vasc Neurol. 2019 Jul; 2019 Mar 2. PMID: 31338212.", + "CD34(+)KLF4(+) Stromal Stem Cells Contribute to Endometrial Regeneration and Repair. Yin M, Zhou HJ, Lin C, Long L, Yang X, Zhang H, Taylor H, Min W. Cell Rep. 2019 May 28. PMID: 31141693.", + "Critical role of Lin28-TNFR2 signalling in cardiac stem cell activation and differentiation. Xiang Q, Yang B, Li L, Qiu B, Qiu C, Gao XB, Zhou HJ, Min W. J Cell Mol Med. 2019 Apr; 2019 Feb 7. PMID: 30734494.", + "SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis. Zhou HJ, Xu Z, Wang Z, Zhang H, Zhuang ZW, Simons M, Min W. Nat Commun. 2018 Aug 17; 2018 Aug 17. PMID: 30120232.", + "Endothelial AIP1 Regulates Vascular Remodeling by Suppressing NADPH Oxidase-2. Zhang J, Chen C, Li L, Zhou HJ, Li F, Zhang H, Yu L, Chen Y, Min W. Front Physiol. 2018; 2018 Apr 20. PMID: 29731721.", + "ASK family in cardiovascular biology and medicine. Liu T, Zhou HJ, Min W. Adv Biol Regul. 2017 Dec; 2017 Oct 24. PMID: 29107568.", + "ASK1-dependent endothelial cell activation is critical in ovarian cancer growth and metastasis. Yin M, Zhou HJ, Zhang J, Lin C, Li H, Li X, Li Y, Zhang H, Breckenridge DG, Ji W, Min W. JCI Insight. 2017 Sep 21; 2017 Sep 21. PMID: 28931753.", + "Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression. Tan S, Feng B, Yin M, Zhou HJ, Lou G, Ji W, Li Y, Min W. Cell Biosci. 2017; 2017 Jul 25. PMID: 28770041.", + "The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk. Chen C, Li L, Zhou HJ, Min W. Antioxidants (Basel). 2017 Jun 8; 2017 Jun 8. PMID: 28594389.", + "Mechanistic Role of Thioredoxin 2 in Heart Failure. Chen C, Chen H, Zhou HJ, Ji W, Min W. Adv Exp Med Biol. 2017. PMID: 28551792.", + "Mitochondrial Redox Signaling and Tumor Progression. Chen Y, Zhang H, Zhou HJ, Ji W, Min W. Cancers (Basel). 2016 Mar 25; 2016 Mar 25. PMID: 27023612.", + "SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression. Shao L, Zhou HJ, Zhang H, Qin L, Hwa J, Yun Z, Ji W, Min W. Nat Commun. 2015 Nov 24; 2015 Nov 24. PMID: 26596471.", + "AIP1 Expression in Tumor Niche Suppresses Tumor Progression and Metastasis. Ji W, Li Y, He Y, Yin M, Zhou HJ, Boggon TJ, Zhang H, Min W. Cancer Res. 2015 Sep 1; 2015 Jul 2. PMID: 26139244.", + "Thioredoxin-2 inhibits mitochondrial reactive oxygen species generation and apoptosis stress kinase-1 activity to maintain cardiac function. Huang Q, Zhou HJ, Zhang H, Huang Y, Hinojosa-Kirschenbaum F, Fan P, Yao L, Belardinelli L, Tellides G, Giordano FJ, Budas GR, Min W. Circulation. 2015 Mar 24; 2015 Jan 27. PMID: 25628390.", + "Carbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell death. Ji W, Yang M, Praggastis A, Li Y, Zhou HJ, He Y, Ghazvinian R, Cincotta DJ, Rice KP, Min W. PLoS One. 2014; 2014 Jul 28. PMID: 25068797.", + "AIP1 mediates vascular endothelial cell growth factor receptor-3-dependent angiogenic and lymphangiogenic responses. Zhou HJ, Chen X, Huang Q, Liu R, Zhang H, Wang Y, Jin Y, Liang X, Lu L, Xu Z, Min W. Arterioscler Thromb Vasc Biol. 2014 Mar; 2014 Jan 9. PMID: 24407031.", + "Novel action and mechanism of auranofin in inhibition of vascular endothelial growth factor receptor-3-dependent lymphangiogenesis. Chen X, Zhou HJ, Huang Q, Lu L, Min W. Anticancer Agents Med Chem. 2014. PMID: 24913775.", + "Thioredoxin and redox signaling in vasculature-studies using Trx2 endothelium-specific transgenic mice. Min W, Xu LK, Zhou HJ, Huang Q, Zhang H, He Y, Zhe X, Luo Y. Methods Enzymol. 2010; 2010 Jun 20. PMID: 20609919.", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Jensen Lab", + "lab_url": "https://medicine.yale.edu/lab/jensen/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/jensen/pubs/", + "publications": [ + "Yale School of Medicine /", + "Therapeutic Radiology /", + "Research", + "People", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "", + "", + "", + "", + "", + "", + "BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments. Lahiri S, Hamilton G, Moore G, Goehring L, Huang TT, Jensen RB, Rothenberg E. Nature. 2025 Apr; 2025 Mar 26. PMID: 40140565.", + "PARG inhibition induces nuclear aggregation of PARylated PARP1. Paradkar S, Purcell J, Cui A, Friedman S, Noronha KJ, Murray MA, Sundaram RK, Bindra RS, Jensen RB. Structure. 2024 Nov 7; 2024 Oct 14. PMID: 39406247.", + "Dormant origin firing promotes head-on transcription-replication conflicts at transcription termination sites in response to BRCA2 deficiency. Goehring L, Keegan S, Lahiri S, Xia W, Kong M, Jimenez-Sainz J, Gupta D, Drapkin R, Jensen RB, Smith DJ, Rothenberg E, Fenyö D, Huang TT. Nat Commun. 2024 Jun 3; 2024 Jun 3. PMID: 38830843.", + "Human DNA polymerase θ does not harbor intrinsic nuclease activity. Carvajal-Maldonado D, Zahn K, Jensen R, Wood RD, Doublié S. Mol Cell. 2024 Apr 18. PMID: 38640889.", + "The importance of considering competing risks in recurrence analysis of intracranial meningioma. Mirian C, Jensen LR, Juratli TA, Maier AD, Torp SH, Shih HA, Morshed RA, Young JS, Magill ST, Bertero L, Stummer W, Spille DC, Brokinkel B, Oya S, Miyawaki S, Saito N, Proescholdt M, Kuroi Y, Gousias K, Simon M, Moliterno J, Prat-Acin R, Goutagny S, Prabhu VC, Tsiang JT, Wach J, Güresir E, Yamamoto J, Kim YZ, Lee JH, Koshy M, Perumal K, Baskaya MK, Cannon DM, Shrieve DC, Suh CO, Chang JH, Kamenova M, Straumann S, Soleman J, Eyüpoglu IY, Catalan T, Lui A, Theodosopoulos PV, McDermott MW, Wang F, Guo F, Góes P, de Paiva Neto MA, Jamshidi A, Komotar R, Ivan M, Luther E, Souhami L, Guiot MC, Csonka T, Endo T, Barrett OC, Jensen R, Gupta T, Patel AJ, Klisch TJ, Kim JW, Maiuri F, Barresi V, Tabernero MD, Skyrman S, Broechner A, Bach MJ, Law I, Scheie D, Kristensen BW, Munch TN, Meling T, Fugleholm K, Blanche P, Mathiesen T. J Neurooncol. 2024 Feb; 2024 Feb 10. PMID: 38336917.", + "BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA. Bell JC, Dombrowski CC, Plank JL, Jensen RB, Kowalczykowski SC. Proc Natl Acad Sci U S A. 2023 Apr 4; 2023 Mar 28. PMID: 36976771.", + "BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair. Jimenez-Sainz J, Mathew J, Moore G, Lahiri S, Garbarino J, Eder JP, Rothenberg E, Jensen RB. Elife. 2022 Sep 13; 2022 Sep 13. PMID: 36098506.", + "DNA fiber combing protocol using in-house reagents and coverslips to analyze replication fork dynamics in mammalian cells. Moore G, Jimenez Sainz J, Jensen RB. STAR Protoc. 2022 Jun 17; 2022 May 5. PMID: 35573479.", + "Reply to 'Paracetamol use in pregnancy - neglecting context promotes misinterpretation'. Bauer AZ, Swan SH, Kriebel D, Liew Z, Taylor HS, Bornehag CG, Andrade AM, Olsen J, Jensen RH, Mitchell RT, Skakkebaek NE, Kristensen DM. Nat Rev Endocrinol. 2022 Jun. PMID: 35277661.", + "The Pathogenic R3052W BRCA2 Variant Disrupts Homology-Directed Repair by Failing to Localize to the Nucleus. Jimenez-Sainz J, Krysztofiak A, Garbarino J, Rogers F, Jensen RB. Front Genet. 2022; 2022 May 30. PMID: 35711920.", + "Reply to 'Paracetamol use in pregnancy - caution over causal inference from available data'; 'Handle with care - interpretation, synthesis and dissemination of data on paracetamol in pregnancy'. Bauer AZ, Swan SH, Kriebel D, Liew Z, Taylor HS, Bornehag CG, M Andrade A, Olsen J, Jensen RH, Mitchell RT, Skakkebaek NE, Kristensen DM. Nat Rev Endocrinol. 2022 Mar. PMID: 34907342.", + "Paracetamol use during pregnancy - a call for precautionary action. Bauer AZ, Swan SH, Kriebel D, Liew Z, Taylor HS, Bornehag CG, Andrade AM, Olsen J, Jensen RH, Mitchell RT, Skakkebaek NE, Jégou B, Kristensen DM. Nat Rev Endocrinol. 2021 Dec; 2021 Sep 23. PMID: 34556849.", + "Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity. Garbarino J, Eckroate J, Sundaram RK, Jensen RB, Bindra RS. Transl Oncol. 2021 Sep; 2021 Jun 9. PMID: 34118569.", + "Polymerase θ Coordinates Multiple Intrinsic Enzymatic Activities during DNA Repair. Zahn KE, Jensen RB. Genes (Basel). 2021 Aug 25; 2021 Aug 25. PMID: 34573292.", + "Imprecise Medicine: BRCA2 Variants of Uncertain Significance (VUS), the Challenges and Benefits to Integrate a Functional Assay Workflow with Clinical Decision Rules. Jimenez-Sainz J, Jensen RB. Genes (Basel). 2021 May 20; 2021 May 20. PMID: 34065235.", + "RETRACTED: Human DNA polymerase θ harbors DNA end-trimming activity critical for DNA repair. Zahn KE, Jensen RB, Wood RD, Doublié S. Mol Cell. 2021 Apr 1; 2021 Feb 11. PMID: 33577776.", + "DNA Strand Exchange to Monitor Human RAD51-Mediated Strand Invasion and Pairing. Lahiri S, Jensen RB. Methods Mol Biol. 2021. PMID: 32840775.", + "Preserving genome integrity in human cells via DNA double-strand break repair. Jensen RB, Rothenberg E. Mol Biol Cell. 2020 Apr 15. PMID: 32286930.", + "The Post-Synaptic Function of Brca2. Wang CX, Jimenez-Sainz J, Jensen RB, Mazin AV. Sci Rep. 2019 Mar 14; 2019 Mar 14. PMID: 30872704.", + "A cell-penetrating antibody inhibits human RAD51 via direct binding. Turchick A, Hegan DC, Jensen RB, Glazer PM. Nucleic Acids Res. 2017 Nov 16. PMID: 29036688.", + "BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing. Zhao W, Steinfeld JB, Liang F, Chen X, Maranon DG, Jian Ma C, Kwon Y, Rao T, Wang W, Sheng C, Song X, Deng Y, Jimenez-Sainz J, Lu L, Jensen RB, Xiong Y, Kupfer GM, Wiese C, Greene EC, Sung P. Nature. 2017 Oct 19; 2017 Oct 4. PMID: 28976962.", + "Enhancement of BLM-DNA2-Mediated Long-Range DNA End Resection by CtIP. Daley JM, Jimenez-Sainz J, Wang W, Miller AS, Xue X, Nguyen KA, Jensen RB, Sung P. Cell Rep. 2017 Oct 10. PMID: 29020620.", + "Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G. JAMA Oncol. 2017 May 1. PMID: 28241208.", + "A Delphic consensus assessment: imaging and biomarkers in gastroenteropancreatic neuroendocrine tumor disease management. Oberg K, Krenning E, Sundin A, Bodei L, Kidd M, Tesselaar M, Ambrosini V, Baum RP, Kulke M, Pavel M, Cwikla J, Drozdov I, Falconi M, Fazio N, Frilling A, Jensen R, Koopmans K, Korse T, Kwekkeboom D, Maecke H, Paganelli G, Salazar R, Severi S, Strosberg J, Prasad V, Scarpa A, Grossman A, Walenkamp A, Cives M, Virgolini I, Kjaer A, Modlin IM. Endocr Connect. 2016 Sep; 2016 Aug 31. PMID: 27582247.", + "The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype. Marsden CG, Jensen RB, Zagelbaum J, Rothenberg E, Morrical SW, Wallace SS, Sweasy JB. PLoS Genet. 2016 Aug; 2016 Aug 11. PMID: 27513445.", + "Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity. Chatterjee G, Jimenez-Sainz J, Presti T, Nguyen T, Jensen RB. Nucleic Acids Res. 2016 Jun 20; 2016 Apr 15. PMID: 27084934.", + "Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry. Zhao W, Vaithiyalingam S, San Filippo J, Maranon DG, Jimenez-Sainz J, Fontenay GV, Kwon Y, Leung SG, Lu L, Jensen RB, Chazin WJ, Wiese C, Sung P. Mol Cell. 2015 Jul 16; 2015 Jul 2. PMID: 26145171.", + "A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study. Schuster J, Lai RK, Recht LD, Reardon DA, Paleologos NA, Groves MD, Mrugala MM, Jensen R, Baehring JM, Sloan A, Archer GE, Bigner DD, Cruickshank S, Green JA, Keler T, Davis TA, Heimberger AB, Sampson JH. Neuro Oncol. 2015 Jun; 2015 Jan 13. PMID: 25586468.", + "Purification of recombinant 2XMBP tagged human proteins from human cells. Jensen R. Methods Mol Biol. 2014. PMID: 25030930.", + "BRCA2: one small step for DNA repair, one giant protein purified. Jensen RB. Yale J Biol Med. 2013 Dec 13; 2013 Dec 13. PMID: 24348212.", + "Purified human BRCA2 stimulates RAD51-mediated recombination. Jensen RB, Carreira A, Kowalczykowski SC. Nature. 2010 Oct 7. PMID: 20729832.", + "Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions. Jensen R, Glazer PM. Proc Natl Acad Sci U S A. 2004 Apr 20; 2004 Apr 6. PMID: 15069205.", + "Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Mihaylova VT, Bindra RS, Yuan J, Campisi D, Narayanan L, Jensen R, Giordano F, Johnson RS, Rockwell S, Glazer PM. Mol Cell Biol. 2003 May. PMID: 12697826.", + "ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Peretz S, Jensen R, Baserga R, Glazer PM. Proc Natl Acad Sci U S A. 2001 Feb 13; 2001 Feb 6. PMID: 11172010.", + "15 York Street New Haven, CT 06520", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Jun Deng Team", + "lab_url": "https://medicine.yale.edu/lab/deng/", + "research_bio": "INFORMATION FOR Welcome to Yale Smart Medicine Lab (YSML), an evolving neural network where members interact, collaborate, and spark constantly. Although scattered around the world, we find our team virtually. Our team members excel in various disciplines such as physics, mathematics, statistics, computer science, data science, radiology, biomedical engineering, biology, clinical medicine and public health. The PI, Dr. Jun Deng is a Professor at the Department of Therapeutic Radiology of Yale University School of Medicine and an ABR board certified medical physicist at Yale New Haven Hospital. Dr. Deng obtained his PhD from University of Virginia in 1998 and finished his postdoctoral fellowship at Stanford University in 2001. Dr. Deng has been serving on the Editorial Board of numerous peer-reviewed journals, on the study sections of NIH, NSF, DOD, ACS, RSNA and ASTRO since 2005, and as scientific reviewer for various science foundations and institutions since 2015. Currently with funding from NIBIB, NSF, NCI, DOE and YCC, Dr. Deng’s research has been focused on artificial intelligence, machine learning, and big data for early cancer detection, real-time clinical decision support, digital twins of cancer patients, as well as AI-empowered mobile health and smart medicine. We are hiring! We need your talent and expertise! If interested,contact Dr. Deng. Copy Link Dr. Jun Deng, PhD, DABR, FAAPM, FASTRO, Professor of Therapeutic Radiology, has recently been selected as one of the 15 experts for the NIH's Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity (AIM-AHEAD) Program for Artificial Intelligence Readiness (PAIR). The AIM-AHEAD PAIR aims to leverage AIM-AHEAD resources to jump start AI research for health equity in minority serving institutions (MSI) with inadequate resources. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/deng/pubs/", + "publications": [ + "Yale School of Medicine /", + "Therapeutic Radiology /", + "Research", + "CT Gently", + "Selected Publications", + "Collaborators & Students", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "CT Gently", + "Selected Publications", + "Collaborators & Students", + "", + "", + "", + "", + "", + "", + "The Arabidopsis neutral amino acid transporter UmamiT20 confers Botrytis cinerea susceptibility. Prior MJ, Weidauer D, Locci F, Liao JY, Kuwata K, Deng C, Ye HB, Cai Q, Bezrutczyk M, Zhao C, Jonikas MC, Pilot G, Jin H, Parker JE, Frommer WB, Kim JY. J Exp Bot. 2025 Nov 13; 2025 Nov 13. PMID: 41230912.", + "Connectivity, Computation, and Plasticity of the Early Visual System. Shi X, Wei W, Deng Z, Li C, Glickfeld LL, Smith GB, Triplett JW, Gu Y. J Neurosci. 2025 Nov 12; 2025 Nov 12. PMID: 41224666.", + "Novel PEEK fabrication using fused strand deposition reduces inflammation and enhances MSC differentiation promoting bone growth and implant osseointegration. Cohen DJ, Deng J, Reith TM, Sabalewski EL, Pestov D, Dillon JT, Jawad AY, Slosar PJ, Foley KT, Dryer RF, Bassett TD, Harrod CC, Verrelli BC, Bertino MF, Erbe EM, Schwartz Z, Boyan BD. Biomaterials. 2025 Nov 4; 2025 Nov 4. PMID: 41213206.", + "TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes STK11-Mutant Tumors to Anti-PD-1 Immunotherapy. Ahronian LG, Sahu S, Zhang M, Patel AS, Geng K, Bhattacharya R, Falchook GS, Goldman JW, Spira AI, Punekar SR, Spigel DR, Wang JS, Skoulidis F, Stephens J, Meynardie M, Powell JM, Lopez A, Ranieri M, Ploszaj MA, Tan YJ, Lee YT, Yu Y, Deng J, Chen T, McCarren P, Tsai A, Hussain SS, Doyon B, Amemiya K, Ermolieff J, Shahagadkar P, Das NM, Flynn LR, Shields JA, Danielczyk L, McMillan BJ, Mignault A, Meier SR, Wu HJ, Guerin DJ, Whittington DA, Min C, Sienczylo I, Maxwell JP, DiBenedetto HJ, Watanabe H, Haines BB, Huang A, Crystal A, Andersen JN, Wu X, Wong KK. Cancer Res. 2025 Oct 15. PMID: 40882030.", + "Speedy A governs non-homologous XY chromosome desynapsis as a unique prerequisite for XY loop-axis organization. Liu D, Zhang Y, Li D, Jiang B, Zhao X, Li Y, Lin Z, Zhao Y, Hu Z, Deng S, Li Z, Lu H, Chan KKL, Yeung WSB, Kaldis P, Yao C, Wang H, Chow LT, Liu K. EMBO J. 2025 Oct; 2025 Aug 18. PMID: 40826181.", + "Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factors in 204 Countries and Territories, 1990-2023. J Am Coll Cardiol. 2025 Sep 24; 2025 Sep 24. PMID: 40990886.", + "Interobserver and Intraobserver Variability in the Assessment of Prolonged Venous Transit in Anterior Circulation Large-Vessel Occlusion Ischemic Stroke. Salim HA, Barghash M, Lakhani DA, Balar A, Mei J, Moon J, Greene C, Luna L, Hyson NZ, Deng F, Dmytriw AA, Guenego A, Marsh EB, Lu H, Xu R, Leigh R, Shah G, Albers GW, Hillis AE, Llinas R, Nael K, Wintermark M, Heit JJ, Faizy TD, Yedavalli V. AJNR Am J Neuroradiol. 2025 Sep 2; 2025 Sep 2. PMID: 40841160.", + "A comparison of outcomes after radiosurgery in non-small cell lung cancer patients with one versus more than twenty brain metastases: an international multi-center study. Wei CZ, Shanahan R, Puccio D, Deng H, Lee CC, Yang HC, Cifarelli CP, Hack JD, Cifarelli DT, Peker S, Samanci Y, Mathieu D, Blanchard J, Perlow HK, Palmer JD, Tripathi M, Moreno NM, Martínez Álvarez R, Speckter H, Hernandez W, Liščák R, May J, Elhamdani S, Shepard MJ, Wegner R, Hadjipanayis CG, Lunsford LD, Niranjan A. J Neurooncol. 2025 Sep; 2025 Jun 3. PMID: 40459832.", + "Targeted immunotherapy with sphingosine-1-phosphate improves myocardial contractility and mitochondrial function in a novel murine ex vivo perfusion and transplantation model. Iguidbashian J, Zakrzewski J, Lu L, Garcia AM, Khailova L, Deng X, Plenter R, La Rosa FG, Nakano S, Lynch K, Jaggers J, Davidson J, Stone ML. J Thorac Cardiovasc Surg. 2025 Sep; 2025 Mar 3. PMID: 40043942.", + "Effect of hypertension on long-term adverse clinical outcomes and liver fibrosis progression in MASLD. Zhou XD, Lian LY, Chen QF, Kim SU, Cheuk-Fung Yip T, Petta S, Nakajima A, Tsochatzis E, Shi J, Chan WK, Boursier J, Bugianesi E, Yilmaz Y, Hagström H, Romero-Gomez M, Alswat K, Calleja JL, Takahashi H, de Lédinghen V, Shalimar, Castéra L, Sanyal AJ, Goh GB, Newsome PN, Fan JG, Lai M, Aggarwal S, Kechagias S, Hiasa Y, Dayal B, Zhang Z, George J, El-Kassas M, Chen J, You H, Abu Dayyeh BK, Sheng H, Adams LA, Wang J, He F, Liang H, Yang YF, Chi X, Zhong B, Bi Y, Mi Y, Zhu Y, Bai R, Zhang J, Wang B, Song J, Deng H, Xie Q, Bai L, Xin Y, Xie W, Li J, Fournier-Poizat C, Zoncapè M, Xia T, Ju S, Wu C, Lee HW, Wong GL, Armandi A, Shang Y, Pennisi G, Llop E, Yoneda M, de Saint-Loup M, Canivet CM, Lara-Romero C, Gallego-Durán R, Carrillo-Fernández P, Asgharpour A, Teh KK, Mahgoub S, Chan MS, Lin H, Liu WY, Song SJ, Al-Hamoudi WK, Isoda H, Miyake T, Satapathy SK, Li M, Sharma K, Emadeldeen M, Zhou L, Tong X, Bazerbachi F, Fan X, Xiao H, Ye J, Xu L, Wang X, Targher G, Byrne CD, Shapiro MD, Tacke F, Wai-Sun Wong V, Zheng MH. J Hepatol. 2025 Aug 23; 2025 Aug 23. PMID: 40854336.", + "Infographic. School-based factors promoting physical activity participation for children and adolescents with disabilities. Deng Y, Li X, Huang J, Haegele JA, Smith B, Li C. Br J Sports Med. 2025 Jul 1; 2025 Jul 1. PMID: 40268336.", + "Remodeling Process of the Tendon Graft After Anterior Cruciate Ligament Reconstruction: Comprehensive Analysis With RNA Sequencing in a Murine Model. Wada S, Fujii T, Carballo CB, Suzuki Y, Song Z, Liu Y, Zhang X, Croen BJ, Bhandari R, Deng XH, Rodeo SA. J Orthop Res. 2025 Jun; 2025 Mar 10. PMID: 40064586.", + "Cardiopulmonary complications in cancer: from tumour pathogenesis to treatment-induced toxicity and clinical management. Mao Z, Wang X, Chen S, Zhang C, Chen Y, Deng S, Liu Y, Xu X, Zhang T, Liao J, He Y, Wang W, Zeng T, Song Y. Postgrad Med J. 2025 May 31; 2025 May 31. PMID: 40448347.", + "The Effect of Plant Quercetin on Immune Function of Microtus Fortis. An Y, Yang D, Ma B, Liu D, Deng K, Tao S, Cai H, Ou Y, Li J. J Chem Ecol. 2025 May 28; 2025 May 28. PMID: 40437256.", + "Effectiveness over time of a primary series of the original monovalent COVID-19 vaccines in adults in the United States. Layton JB, Lloyd PC, Peetluk LS, Jiao Y, Djibo DA, Gruber JF, Deng J, Bui C, Lo AC, Ogilvie RP, Parambi R, Miller M, Song J, Weatherby LB, Cho S, Wong HL, Clarke TC, Hervol JR, Illei D, Bell EJ, Yang GW, Seeger JD, Wernecke M, Richey MM, Forshee RA, Anderson SA, Chillarige Y, McMahill-Walraven CN, Amend KL, Anthony MS, Shoaibi A. PLoS One. 2025; 2025 May 6. PMID: 40327641.", + "Prolonged Venous Transit as a Superior Predictor of Functional Outcomes in Successfully Reperfused Large Vessel Occlusions: Comparative Analysis With Cerebral Blood Volume Index and Hypoperfusion Intensity Ratio. Mei J, Salim HA, Lakhani DA, Balar A, Vagal V, Koneru M, Wolman D, Xu R, Urrutia V, Marsh EB, Pulli B, Hoseinyazdi M, Luna L, Deng F, Hyson NZ, Shahriari M, Dmytriw AA, Guenego A, Albers GW, Lu H, Nael K, Hillis AE, Llinas R, Wintermark M, Faizy TD, Heit JJ, Yedavalli V. J Am Heart Assoc. 2025 Apr 15; 2025 Apr 7. PMID: 40194971.", + "Sedation Versus General Anesthesia for Ablation of Ventricular Arrhythmias: A Systematic Review and Meta-Analysis. Patel S, Deng J, Zubair A, Heybati K, Heybati S, Chang O, Abbas U, Tahir U, Ramaraju HB, Wong CY, Dhivagaran T, Rayner D, Krever M, Woelber T, Kowlgi GN, Ramakrishna H. Ann Card Anaesth. 2025 Apr 1; 2025 Apr 16. PMID: 40237657.", + "Hypoperfusion Intensity Ratio Less Than 0.4 Is Associated with Favorable Outcomes in Unsuccessfully Reperfused Acute Ischemic Stroke with Large-Vessel Occlusion. Yedavalli V, Salim HA, Balar A, Lakhani DA, Mei J, Lu H, Luna L, Deng F, Vagal V, Hyson NZ, Fiehler J, Stracke P, Broocks G, Heitkamp C, Albers GW, Wintermark M, Faizy TD, Heit JJ. AJNR Am J Neuroradiol. 2025 Mar 4; 2025 Mar 4. PMID: 39979027.", + "Efficacy and Safety of Automated Insulin Delivery Systems in Patients with Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Fan W, Deng C, Xu R, Liu Z, Leslie RD, Zhou Z, Li X. Diabetes Metab J. 2025 Mar; 2024 Nov 13. PMID: 39533812.", + "T-cell immune checkpoint inhibition plus hypomethylation for locally advanced HER2-negative breast cancer: a phase 2 neoadjuvant window trial of decitabine and pembrolizumab followed by standard neoadjuvant chemotherapy. Bear HD, Deng X, Bandyopadhyay D, Idowu M, Jenkins TM, Kmieciak M, Williams M, Archer G, Gwaltney L, Dillon P, Flora D, Stover D, Poklepovic AS, Hackney M, Ross M, Vachhani H, Louie R, McGuire KP, Grover A, Rahman T, Hendrix A. J Immunother Cancer. 2025 Feb 27; 2025 Feb 27. 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PMID: 39809719.", + "Prolonged venous transit is associated with lower odds of excellent recovery after reperfusion in anterior large-vessel occlusion stroke. Salim HA, Lakhani DA, Mei J, Luna L, Shahriari M, Hyson NZ, Deng F, Dmytriw AA, Guenego A, Urrutia VC, Marsh EB, Lu H, Xu R, Leigh R, Wolman D, Shah G, Pulli B, Albers GW, Hillis AE, Llinas R, Nael K, Wintermark M, Heit JJ, Faizy TD, Yedavalli V. Eur J Neurol. 2025 Jan. PMID: 39620268.", + "Preference Signaling in the Radiology Residency Match: National Survey of Applicants. Lakhani DA, Radmard M, Tafazolimoghadam A, Patel S, Murugesan A, Malik H, Hogg JP, Shen Z, Yousem DM, Deng F. J Am Coll Radiol. 2025 Jan; 2024 Aug 30. PMID: 39216781.", + "10-year retention of a comprehensive treatment model of buprenorphine for opioid use disorder. Zheng W, Cavrak M, Bowles H, Deng Y, Wen S, Gao S, Lander L, Berry J, Winstanley EL. J Addict Dis. 2025 Jan-Mar; 2024 Feb 24. PMID: 38400724.", + "CT perfusion derived relative cerebral blood volume < 42 % is negatively associated with poor functional outcomes at discharge in anterior circulation large vessel occlusion stroke. Lakhani DA, Balar AB, Vagal V, Salim H, Mei J, Koneru M, Wen S, Berksu Ozkara B, Lu H, Wang R, Xu R, Nabi M, Mazumdar I, Cho A, Chen K, Sepehri S, Deng F, Hyson N, Urrutia V, Luna LP, Sriwastwa A, Hillis AE, Heit JJ, Albers GW, Rai AT, Dmytriw AA, Faizy TD, Wintermark M, Nael K, Yedavalli VS. J Clin Neurosci. 2024 Dec; 2024 Nov 13. PMID: 39536379.", + "Effectiveness and Feasibility of Digital Pulmonary Rehabilitation in Patients Undergoing Lung Cancer Surgery: Systematic Review and Meta-Analysis. Lu T, Deng T, Long Y, Li J, Hu A, Hu Y, Ouyang L, Wang H, Ma J, Chen S, Hu J. J Med Internet Res. 2024 Nov 11; 2024 Nov 11. PMID: 39527799.", + "Medical-Dental Collaboration. Deng Y, Wan L, Zheng W. J Am Dent Assoc. 2024 Nov; 2024 Sep 30. PMID: 39352369.", + "Defining optimal left ventricular assist device short-term outcomes may provide insight into programmatic quality assessment. Cowger JA, Molina E, Deng L, Kanwar M, Shah P, Cogswell R, Gosev I, Cantor RS, Dardas TF, Kirklin JK, Rogers JG, Cleveland JC, Sandau KE, McIlvennan CK, Kaczorowski D, Estep JD, Pagani FD. J Heart Lung Transplant. 2024 Nov; 2024 Aug 12. PMID: 39142525.", + "Availability of lasers and hands-on training in cosmetic dermatology in residency. Kang BY, Stratman EJ, Hu JC, Elsanadi R, Greywal T, Kelly KM, Ortiz A, Saikaly SK, Suozzi KC, Bolotin D, Minkis K, Alam M. J Am Acad Dermatol. 2024 Nov; 2024 Jul 6. PMID: 38972481.", + "Amino Acid Compound 2 (AAC2) Treatment Counteracts Insulin-Induced Synaptic Gene Expression and Seizure-Related Mortality in a Mouse Model of Alzheimer's Disease. Deng Z, Lee A, Lin T, Taneja S, Kowdley D, Leung JH, Hill M, Tao T, Fitzgerald J, Yu L, Blakeslee JJ, Townsend K, Weil ZM, Parquette JR, Ziouzenkova O. Int J Mol Sci. 2024 Oct 30; 2024 Oct 30. PMID: 39519239.", + "CHARMM at 45: Enhancements in Accessibility, Functionality, and Speed. Hwang W, Austin SL, Blondel A, Boittier ED, Boresch S, Buck M, Buckner J, Caflisch A, Chang HT, Cheng X, Choi YK, Chu JW, Crowley MF, Cui Q, Damjanovic A, Deng Y, Devereux M, Ding X, Feig MF, Gao J, Glowacki DR, Gonzales JE 2nd, Hamaneh MB, Harder ED, Hayes RL, Huang J, Huang Y, Hudson PS, Im W, Islam SM, Jiang W, Jones MR, Käser S, Kearns FL, Kern NR, Klauda JB, Lazaridis T, Lee J, Lemkul JA, Liu X, Luo Y, MacKerell AD Jr, Major DT, Meuwly M, Nam K, Nilsson L, Ovchinnikov V, Paci E, Park S, Pastor RW, Pittman AR, Post CB, Prasad S, Pu J, Qi Y, Rathinavelan T, Roe DR, Roux B, Rowley CN, Shen J, Simmonett AC, Sodt AJ, Töpfer K, Upadhyay M, van der Vaart A, Vazquez-Salazar LI, Venable RM, Warrensford LC, Woodcock HL, Wu Y, Brooks CL 3rd, Brooks BR, Karplus M. J Phys Chem B. 2024 Oct 17; 2024 Sep 20. PMID: 39303207.", + "Proteogenomic analysis integrated with electronic health records data reveals disease-associated variants in Black Americans. Tahir UA, Barber JL, Cruz DE, Kars ME, Deng S, Tuftin B, Gillman MG, Benson MD, Robbins JM, Chen ZZ, Rao P, Katz DH, Farrell L, Sofer T, Hall ME, Ekunwe L, Tracy RP, Durda P, Taylor KD, Liu Y, Johnson WC, Guo X, Chen YI, Manichaikul AW, Jain D, Wang TJ, Reiner AP, Natarajan P, Itan Y, Rich SS, Rotter JI, Wilson JG, Raffield LM, Gerszten RE. J Clin Invest. 2024 Sep 24; 2024 Sep 24. PMID: 39316441.", + "Functional Divergence in the Affinity and Stability of Non-Canonical Cysteines and Non-Canonical Disulfide Bonds: Insights from a VHH and VNAR Study. Xu M, Zhao Z, Deng P, Sun M, Chiu CKC, Wu Y, Wang H, Bi Y. Int J Mol Sci. 2024 Sep 11; 2024 Sep 11. PMID: 39337289.", + "Reduced osseointegration in disuse and denervation rat models results from impaired cellular responses to multiscale microstructured titanium surfaces. Deng J, Joshua Cohen D, Matias EB, Olson LC, McClure MJ, Boyan BD, Schwartz Z. J Orthop Res. 2024 Sep; 2024 Apr 21. PMID: 38644051.", + "Sociodemographic and clinical characteristics associated with rehabilitation services utilization in older women with early-stage breast cancer from SEER-Medicare 2009-2018. Gorzelitz JS, Brick R, Deng L, Mollica M, Stout N, Stoller S, Williams CP. J Cancer Surviv. 2024 Aug 8; 2024 Aug 8. PMID: 39115791.", + "Redefining the molecular rejection states in 3230 heart transplant biopsies: Relationships to parenchymal injury and graft survival. Halloran PF, Madill-Thomsen K, Aliabadi-Zuckermann AZ, Cadeiras M, Crespo-Leiro MG, Depasquale EC, Deng M, Gökler J, Hall S, Jamil A, Kim DH, Kobashigawa J, Macdonald P, Melenovsky V, Patel J, Potena L, Shah K, Stehlik J, Zuckermann A. Am J Transplant. 2024 Aug; 2024 Mar 26. PMID: 38527588.", + "Wing deformation improves aerodynamic performance of forward flight of bluebottle flies flying in a flight mill. Hsu SJ, Deng H, Wang J, Dong H, Cheng B. J R Soc Interface. 2024 Jul; 2024 Jul 17. PMID: 39016178.", + "Establishment of a Posttraumatic Osteoarthritis Model in Mice Induced by Noninvasive Anterior Cruciate Ligament Tear. Okazaki Y, Nakagawa Y, Deng XH, Zhang X, Wada S, Album Z, Ying L, Rodeo SA. Am J Sports Med. 2024 Jul; 2024 Jun 3. PMID: 38828660.", + "Isolation and Electrochemical Analysis of a Facultative Anaerobic Electrogenic Strain Klebsiella sp. SQ-1. Zhou L, Tang T, Deng D, Wang Y, Pei D. Pol J Microbiol. 2024 Jun 1; 2024 Apr 27. PMID: 38676960.", + "Wnt16 Increases Bone-to-Implant Contact in an Osteopenic Rat Model by Increasing Proliferation and Regulating the Differentiation of Bone Marrow Stromal Cells. Berger MB, Bosh K, Deng J, Jacobs TW, Cohen DJ, Boyan BD, Schwartz Z. Ann Biomed Eng. 2024 Jun; 2024 Mar 22. PMID: 38517621.", + "Transformation of Motion Pattern Selectivity from Retina to Superior Colliculus. DePiero VJ, Deng Z, Chen C, Savier EL, Chen H, Wei W, Cang J. J Neurosci. 2024 May 15; 2024 May 15. PMID: 38569924.", + "Estradiol induces bone osteolysis in triple-negative breast cancer via its membrane-associated receptor ERα36. Cohen DJ, Dennis CD, Deng J, Boyan BD, Schwartz Z. JBMR Plus. 2024 May; 2024 Mar 26. PMID: 38644978.", + "Strategies for Improving Impaired Osseointegration in Compromised Animal Models. Deng J, Van Duyn C, Cohen DJ, Schwartz Z, Boyan BD. J Dent Res. 2024 May; 2024 Apr 15. PMID: 38616679.", + "Assessing the accuracy, usefulness, and readability of artificial-intelligence-generated responses to common dermatologic surgery questions for patient education: A double-blinded comparative study of ChatGPT and Google Bard. Robinson MA, Belzberg M, Thakker S, Bibee K, Merkel E, MacFarlane DF, Lim J, Scott JF, Deng M, Lewin J, Soleymani D, Rosenfeld D, Liu R, Liu TYA, Ng E. J Am Acad Dermatol. 2024 May; 2024 Feb 1. PMID: 38296195.", + "Digital twins for health: a scoping review. Katsoulakis E, Wang Q, Wu H, Shahriyari L, Fletcher R, Liu J, Achenie L, Liu H, Jackson P, Xiao Y, Syeda-Mahmood T, Tuli R, Deng J. NPJ Digit Med. 2024 Mar 22; 2024 Mar 22. PMID: 38519626.", + "Unveiling Three Interconvertible Redox States of Boraphenalene. Deng CL, Hollister KK, Molino A, Tra BYE, Dickie DA, Wilson DJD, Gilliard RJ Jr. J Am Chem Soc. 2024 Mar 6; 2024 Feb 21. PMID: 38380615.", + "Molecular states associated with dysfunction and graft loss in heart transplants. Halloran PF, Madill-Thomsen K, Mackova M, Aliabadi-Zuckermann AZ, Cadeiras M, Crespo-Leiro MG, Depasquale EC, Deng M, Gökler J, Hall SA, Kim DH, Kobashigawa J, Macdonald P, Potena L, Shah K, Stehlik J, Zuckermann A, Reeve J. J Heart Lung Transplant. 2024 Mar; 2023 Nov 30. PMID: 38042442.", + "Evaluating fluvoxamine for the outpatient treatment of COVID-19: A systematic review and meta-analysis. Deng J, Moskalyk M, Zuo QK, Garcia C, Abbas U, Ramaraju HB, Rayner D, Park YJ, Heybati K, Zhou F, Lohit S. Rev Med Virol. 2024 Jan; 2023 Dec 26. PMID: 38148036.", + "Concordant care in sentinel lymph node omission following Choosing Wisely® recommendations at a comprehensive cancer center. Blue CM, Ong C, Khan J, Deng X, Bandyopadhyay D, Louie RJ, McGuire KP. Am J Surg. 2024 Jan; 2023 Oct 5. PMID: 37821293.", + "Impact of boiling on chemical and physical processes for reduction of halomethanes, haloacetonitriles, and haloacetic acids in drinking water. Ma X, Cheng J, Zhang P, Wu Y, Deng J, Dong F, Li X, Dietrich AM. Sci Total Environ. 2024 Jan 1; 2023 Oct 6. PMID: 37806591.", + "Internal surface modification of additively manufactured macroporous TiAl6V4 biomimetic implants via a calciothermic reaction-based process and osteogenic in vivo responses. Berger MB, Cohen DJ, Deng J, Srivas P, Boyan BD, Sandhage KH, Schwartz Z. J Biomed Mater Res B Appl Biomater. 2024 Jan; 2023 Sep 22. PMID: 37737450.", + "Global Burden of Cardiovascular Diseases and Risks, 1990-2022. Mensah GA, Fuster V, Murray CJL, Roth GA. J Am Coll Cardiol. 2023 Dec 19. PMID: 38092509.", + "Pangolin HKU4-related coronaviruses found in greater bamboo bats from southern China. Guo M, Zhao K, Peng X, He X, Deng J, Wang B, Yang X, Zhang L. Virol Sin. 2023 Dec; 2023 Nov 13. PMID: 37967719.", + "Genome and proteomic analysis of risk factors for fatal outcome in children with severe community-acquired pneumonia caused by human adenovirus 7. Wei J, Zang N, Zhang J, He Y, Huang H, Liu X, Xu X, Ren L, Deng Y, Wu J, Seto D, Zhong W, Zhang Q, Liu E. J Med Virol. 2023 Nov. PMID: 37909805.", + "Virtual Research Groups Increase Research Opportunities for Trainees: Evaluation of the Massachusetts General Hospital Radiology Research Training Collaborative. Elhakim T, Di Capua J, Carter A, Deng F, Chonde DB, Lang M, Dai H, Garg T, Kalva SP, Huang J, Uppot R, Daye D, Som A. J Am Coll Radiol. 2023 Nov; 2023 Sep 1. PMID: 37659449.", + "Electrolyte Modulation of Biological Chelation Additives toward a Dendrite-Free Zn Metal Anode. Li C, Gou Q, Tang R, Deng J, Wang K, Luo H, Cui J, Geng Y, Xiao J, Zheng Y, Li M. J Phys Chem Lett. 2023 Oct 19; 2023 Oct 5. PMID: 37796231.", + "Bis(9-Boraphenanthrene) and Its Stable Biradical. Sarkar SK, Hollister KK, Molino A, Obi AD, Deng CL, Tra BYE, Stewart BM, Dickie DA, Wilson DJD, Gilliard RJ Jr. J Am Chem Soc. 2023 Oct 4; 2023 Sep 22. PMID: 37738168.", + "Epidemiological updates of post-traumatic related limb osteomyelitis in china: a 10 years multicentre cohort study. Ren Y, Liu L, Sun D, Zhang Z, Li M, Lan X, Ni J, Yan MM, Huang W, Liu ZM, Peng A, Zhang Y, Jiang N, Song K, Huang Z, Bi Q, Zhang J, Yang Q, Yang J, Liu Y, Fu W, Tian X, Wang Y, Zhong W, Song X, Abudurexiti A, Xia Z, Jiang Q, Shi H, Liu X, Wang G, Hu Y, Zhang Y, Yin G, Fan J, Feng S, Zhou X, Li Z, He W, Weeks J, Schwarz EM, Kates SL, Huang L, Chai Y, Bin Yu MD, Xie Z, Deng Z, Xie C. Int J Surg. 2023 Sep 1; 2023 Sep 1. PMID: 37247014.", + "Marine energy converters: Potential acoustic effects on fishes and aquatic invertebrates. Popper AN, Haxel J, Staines G, Guan S, Nedelec SL, Roberts L, Deng ZD. J Acoust Soc Am. 2023 Jul 1. PMID: 37497961.", + "BOHEMIA a cluster randomized trial to assess the impact of an endectocide-based one health approach to malaria in Mozambique: baseline demographics and key malaria indicators. Ruiz-Castillo P, Imputiua S, Xie K, Elobolobo E, Nicolas P, Montaña J, Jamisse E, Munguambe H, Materrula F, Casellas A, Deng X, Marathe A, Rabinovich R, Saute F, Chaccour C, Sacoor C. Malar J. 2023 Jun 4; 2023 Jun 4. PMID: 37271818.", + "Visualizing Atomic Quantum Defects in Ultrathin 1T-PtTe(2). Ren J, Zhang L, Wang Q, Wang L, Shi Y, Zhou H, Wang A, Zhao D, Hao T, Zhang L, Deng K, Zhang J, Tanigaki K, Tao C. J Phys Chem Lett. 2023 May 18; 2023 May 9. PMID: 37159549.", + "Enhanced dehalogenation of brominated DBPs by catalyzed electrolysis using Vitamin B(12) modified electrodes: Kinetics, mechanisms, and mass balances. Wang L, Wang H, Deng J, Liu J, Wu Y, Huang S, Ma X, Li X, Dietrich AM. J Hazard Mater. 2023 May 5; 2023 Feb 22. PMID: 36827722.", + "Ursodeoxycholic acid is associated with a reduction in SARS-CoV-2 infection and reduced severity of COVID-19 in patients with cirrhosis. John BV, Bastaich D, Webb G, Brevini T, Moon A, Ferreira RD, Chin AM, Kaplan DE, Taddei TH, Serper M, Mahmud N, Deng Y, Chao HH, Sampaziotis F, Dahman B. J Intern Med. 2023 May; 2023 Apr 5. PMID: 37018129.", + "Efficacy and safety of selective serotonin reuptake inhibitors in COVID-19 management: a systematic review and meta-analysis. Deng J, Rayner D, Ramaraju HB, Abbas U, Garcia C, Heybati K, Zhou F, Huang E, Park YJ, Moskalyk M. Clin Microbiol Infect. 2023 May; 2023 Jan 16. PMID: 36657488.", + "Structural analysis of the P132L disease mutation in caveolin-1 reveals its role in the assembly of oligomeric complexes. Han B, Gulsevin A, Connolly S, Wang T, Meyer B, Porta J, Tiwari A, Deng A, Chang L, Peskova Y, Mchaourab HS, Karakas E, Ohi MD, Meiler J, Kenworthy AK. J Biol Chem. 2023 Apr; 2023 Mar 3. PMID: 36870682.", + "Realization of Multiple Charge-Density Waves in NbTe(2) at the Monolayer Limit. Bai Y, Jian T, Pan Z, Deng J, Lin X, Zhu C, Huo D, Cheng Z, Liu Y, Cui P, Zhang Z, Zou Q, Zhang C. Nano Lett. 2023 Mar 22; 2023 Mar 7. PMID: 36881543.", + "Osseointegration of Titanium Implants in a Botox-Induced Muscle Paralysis Rat Model Is Sensitive to Surface Topography and Semaphorin 3A Treatment. Deng J, Cohen DJ, Berger MB, Sabalewski EL, McClure MJ, Boyan BD, Schwartz Z. Biomimetics (Basel). 2023 Feb 25; 2023 Feb 25. PMID: 36975323.", + "Prevalence of mental health symptoms in children and adolescents during the COVID-19 pandemic: A meta-analysis. Deng J, Zhou F, Hou W, Heybati K, Lohit S, Abbas U, Silver Z, Wong CY, Chang O, Huang E, Zuo QK, Moskalyk M, Ramaraju HB, Heybati S. Ann N Y Acad Sci. 2023 Feb; 2022 Dec 20. PMID: 36537131.", + "Semaphorin 3A delivered by a rapidly polymerizing click hydrogel overcomes impaired implant osseointegration in a rat type 2 diabetes model. Deng J, Cohen DJ, Sabalewski EL, Van Duyn C, Wilson DS, Schwartz Z, Boyan BD. Acta Biomater. 2023 Feb; 2022 Nov 24. PMID: 36435442.", + "Comparative nanoindentation study of biogenic and geological calcite. Deng Z, Chen L, Li L. J Mech Behav Biomed Mater. 2023 Jan; 2022 Oct 23. PMID: 36343519.", + "Challenges of modeling and analysis in cybermanufacturing: a review from a machine learning and computation perspective. Kang S, Jin R, Deng X, Kenett RS. J Intell Manuf. 2023; 2021 Aug 4. PMID: 34376924.", + "Pt Atomic Single-Layer Catalyst Embedded in Defect-Enriched Ceria for Efficient CO Oxidation. Xie S, Liu L, Lu Y, Wang C, Cao S, Diao W, Deng J, Tan W, Ma L, Ehrlich SN, Li Y, Zhang Y, Ye K, Xin H, Flytzani-Stephanopoulos M, Liu F. J Am Chem Soc. 2022 Nov 23; 2022 Nov 2. PMID: 36322840.", + "Occurrence and modeling of disinfection byproducts in distributed water of a megacity in China: Implications for human health. Pang Z, Zhang P, Chen X, Dong F, Deng J, Li C, Liu J, Ma X, Dietrich AM. Sci Total Environ. 2022 Nov 20; 2022 Aug 1. PMID: 35926603.", + "Third dose of COVID-19 mRNA vaccine appears to overcome vaccine hyporesponsiveness in patients with cirrhosis. John BV, Ferreira RD, Doshi A, Kaplan DE, Taddei TH, Spector SA, Paulus E, Deng Y, Bastaich D, Dahman B. J Hepatol. 2022 Nov; 2022 Sep 28. PMID: 36181987.", + "Survival, growth and tag retention of juvenile European eel (Anguilla anguilla L.) with implanted 12 mm passive integrated transponder tags and acoustic tags. Jepsen N, Richter L, Pedersen MI, Deng ZD. J Fish Biol. 2022 Nov; 2022 Sep 10. PMID: 35916269.", + "Exploring approaches for predictive cancer patient digital twins: Opportunities for collaboration and innovation. Stahlberg EA, Abdel-Rahman M, Aguilar B, Asadpoure A, Beckman RA, Borkon LL, Bryan JN, Cebulla CM, Chang YH, Chatterjee A, Deng J, Dolatshahi S, Gevaert O, Greenspan EJ, Hao W, Hernandez-Boussard T, Jackson PR, Kuijjer M, Lee A, Macklin P, Madhavan S, McCoy MD, Mohammad Mirzaei N, Razzaghi T, Rocha HL, Shahriyari L, Shmulevich I, Stover DG, Sun Y, Syeda-Mahmood T, Wang J, Wang Q, Zervantonakis I. Front Digit Health. 2022; 2022 Oct 6. PMID: 36274654.", + "Pioglitazone attenuates ischaemic stroke aggravation by blocking PPARγ reduction and inhibiting chronic inflammation in diabetic mice. Guo Y, Zuo W, Yin L, Gu T, Wang S, Fang Z, Wang B, Dong H, Hou W, Zuo Z, Deng J. Eur J Neurosci. 2022 Sep; 2022 Aug 24. PMID: 35945686.", + "A Composite End Point of Graft Status and eGFR at 1 Year to Improve the Scientific Registry of Transplant Recipients' Five-Tier Rating System. Wang K, Deng Y, Stewart D, Formica RN Jr. J Am Soc Nephrol. 2022 Aug; 2022 May 10. PMID: 35537779.", + "Ras inhibitor farnesylthiosalicylic acid conjugated with IR783 dye exhibits improved tumor-targeting and altered anti-breast cancer mechanisms in mice. Huang QJ, Liao GC, Zhuang XR, Yang ML, Yao JJ, Deng JH, Zhang YM, Wang Y, Qi XX, Pan DF, Guan Y, Huang ZY, Zhang FX, Liu ZQ, Lu LL. Acta Pharmacol Sin. 2022 Jul; 2021 Nov 29. PMID: 34845369.", + "Comparative analyses of American and Asian lotus genomes reveal insights into petal color, carpel thermogenesis and domestication. Zheng P, Sun H, Liu J, Lin J, Zhang X, Qin Y, Zhang W, Xu X, Deng X, Yang D, Wang M, Zhang Y, Song H, Huang Y, Orozco-Obando W, Ming R, Yang M. Plant J. 2022 Jun; 2022 Apr 19. PMID: 35362164.", + "EF-hand protein, EfhP, specifically binds Ca(2+) and mediates Ca(2+) regulation of virulence in a human pathogen Pseudomonas aeruginosa. Kayastha BB, Kubo A, Burch-Konda J, Dohmen RL, McCoy JL, Rogers RR, Mares S, Bevere J, Huckaby A, Witt W, Peng S, Chaudhary B, Mohanty S, Barbier M, Cook G, Deng J, Patrauchan MA. Sci Rep. 2022 May 25; 2022 May 25. PMID: 35614085.", + "Patients with HIV-associated cancers have evidence of increased T cell dysfunction and exhaustion prior to cancer diagnosis. Chaudhary O, Trotta D, Wang K, Wang X, Chu X, Bradley C, Okulicz J, Maves RC, Kronmann K, Schofield CM, Blaylock JM, Deng Y, Schalper KA, Kaech SM, Agan B, Ganesan A, Emu B. J Immunother Cancer. 2022 Apr. PMID: 35470232.", + "Depressive Symptoms and Incident Heart Failure in the Jackson Heart Study: Differential Risk Among Black Men and Women. Gaffey AE, Cavanagh CE, Rosman L, Wang K, Deng Y, Sims M, O'Brien EC, Chamberlain AM, Mentz RJ, Glover LM, Burg MM. J Am Heart Assoc. 2022 Mar; 2022 Feb 22. PMID: 35191315.", + "Many heart transplant biopsies currently diagnosed as no rejection have mild molecular antibody-mediated rejection-related changes. Halloran PF, Madill-Thomsen K, Aliabadi-Zuckermann AZ, Cadeiras M, Crespo-Leiro MG, Depasquale EC, Deng M, Gökler J, Kim DH, Kobashigawa J, Macdonald P, Potena L, Shah K, Stehlik J, Zuckermann A. J Heart Lung Transplant. 2022 Mar; 2021 Aug 26. PMID: 34548198.", + "Insights into metal-organic frameworks HKUST-1 adsorption performance for natural organic matter removal from aqueous solution. Ma X, Wang L, Wang H, Deng J, Song Y, Li Q, Li X, Dietrich AM. J Hazard Mater. 2022 Feb 15; 2021 Sep 22. PMID: 34775305.", + "Spatio-temporal variability of halogenated disinfection by-products in a large-scale two-source water distribution system with enhanced chlorination. Dong F, Pang Z, Yu J, Deng J, Li X, Ma X, Dietrich AM, Deng Y. J Hazard Mater. 2022 Feb 5; 2021 Sep 3. PMID: 34523488.", + "Degradation of saccharin by UV/H(2)O(2) and UV/PS processes: A comparative study. Ye C, Ma X, Deng J, Li X, Li Q, Dietrich AM. Chemosphere. 2022 Feb; 2021 Sep 27. PMID: 34592214.", + "Efficacy of Inhaled Treprostinil on Multiple Disease Progression Events in Patients with Pulmonary Hypertension due to Parenchymal Lung Disease in the INCREASE Trial. Nathan SD, Tapson VF, Elwing J, Rischard F, Mehta J, Shapiro S, Shen E, Deng C, Smith P, Waxman A. Am J Respir Crit Care Med. 2022 Jan 15. PMID: 34767495.", + "The Value of Tyrer-Cuzick Versus Gail Risk Modeling in Predicting Benefit from Screening MRI in Breast Cancer. Sevdalis A, Deng X, Bandyopadhyay D, McGuire KP. Eur J Breast Health. 2022 Jan; 2021 Dec 30. PMID: 35059595.", + "Pheromone antagonism in Plu tella xylostella (Linnaeus) by sex pheromones of two sympatric noctuid moths. Wang FM, Shen ZJ, Schal C, Zhu JJ, Zhou GX, Wang YL, Wang JR, Deng JY, Wan NF. Pest Manag Sci. 2022 Jan; 2021 Oct 2. PMID: 34538026.", + "2021 Canadian Surgery Forum: Virtual, online Sept. 21-24, 2021. 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Ovens K, Gold M, Sorin M, Falutz R, Rayes R, Forghani R, Spicer J, Hunka N, Kennedy R, Bigsby R, Bharadwaj S, Gowing S, Churchill I, Gatti A, Hylton D, Sullivan K, Patel Y, Farrokhyar F, Leontiadis G, Hanna W, Finley C, Begum H, Pearce K, Agzarian J, Hanna W, Shargall Y, Akhtar-Danesh N, Jones D, Anstee C, Kumar S, Gingrich M, Simone A, Ahmadzai Z, Thavorn K, Seely A, Gupta V, Namavarian A, Mohammed A, Uddin S, Jones D, Behzadi A, Brar A, Qu L, Qiabi M, Nayak R, Malthaner R, Peters E, Buduhan G, Tan L, Liu R, Srinathan S, Kidane B, Gupta V, Levy J, Kidane B, Mahar A, Ringash J, Sutradhar R, Darling G, Coburn N, Robinson M, Bednarek L, Buduhan G, Liu R, Tan L, Srinathan S, Kidane B, Wang H, French D, MacDonald D, Graham K, Enns S, Buduhan G, Srinathan S, Liu R, Tan A, Kidane B, Bruinooge A, Poole E, Pascoe C, Karakach T, Buduhan G, Tan L, Srinathan S, Halayko A, Kidane B, Verhoeff K, Mocanu V, Fang B, Dang J, Kung J, Switzer N, Birch D, Karmali S, Johnson G, Singh H, Vergis A, Park J, Hershorn O, Hochman D, Helewa R, Johnson G, Robertson R, Vergis A, Johnson G, Vergis A, Singh H, Park J, Helewa R, Azin A, Cahill C, Lipson M, Afzal A, Maclean A, Wong C, Roen S, Buie W, McKechnie T, Anpalagan T, Chu M, Lee Y, Amin N, Hong D, Eskicioglu C, McKechnie T, Ramji K, Kruse C, Jaffer H, Rebello R, Amin N, Doumouras A, Hong D, Eskicioglu C, Hajjar R, Oliero M, Cuisiniere T, Fragoso G, Calvé A, Djediai S, Annabi B, Richard C, Santos M, Purich K, Zhou Y, Dodd S, Ring B, Yuan Y, White J, Garfinkle R, Dell'Aniello S, Bhatnagar S, Morin N, Ghitulescu G, Faria J, Vasilevsky C, Brassard P, Boutros M, Garfinkle R, Salama E, Amar-Zifkin A, Morin N, Ghitulescu G, Faria J, Vasilevsky C, Boutros M, Talwar G, Daniel R, McKechnie T, Levine O, Eskicioglu C, AlSulaim H, Alqahtani M, Garfinkle R, Al-Masrouri S, Vasilevsky C, Morin N, Boutros M, McKechnie T, Chen A, Patel A, Lee Y, Doumouras A, Hong D, Eskicioglu C, Brissette V, Al Busaidi N, Rajabiyazdi F, Moon J, Demian M, Vasilevsky C, Morin N, Boutros M, Selvam R, Moloo H, MacRae H, Alam F, Raiche I, Holland J, Cwintal M, Rigas G, Vasilevsky C, Morin N, Ghitulescu G, Faria J, Pang A, Boutros M, Holland J, Moon J, Marinescu D, Morin N, Ghitulescu G, Pang A, Vasilevsky C, Boutros M, Brown C, Karimuddin A, Raval M, Phang P, Ghuman A, Li M, Muncner S, Mihajlovic I, Dykstra M, Snelgrove R, Wang H, Monton O, Smith A, Moon J, Demian M, Garfinkle R, Vasilevsky C, Rajabiyazdi F, Boutros M, AlAamer O, AlSelaim N, AlMalki M, Al-Osail A, Ruxton R, Manuel P, Mohamed F, Motamedi MK, Serahati S, Rajendran L, Brown C, Raval M, Karimuddin A, Ghuman A, Phang T, Caminsky N, Moon J, Rajabiyazdi F, Chadi S, Alavi K, Paquette I, MacLean T, Wexner S, Liberman S, Steele S, Park J, Patel S, Bordeianou L, Auer R, Sylla P, Morin N, Ghuman A, Boutros M, Bayat Z, Kennedy E, Victor C, Govindarajan A, Liang J, Vasilevsky C, Pang A, Ghitulescu G, Faria J, Morin N, Boutros M, Marinescu D, Roy H, Baig Z, Karimmudin A, Raval M, Brown C, Phang T, Gill D, Ginther N, Moon J, Marinescu D, Pang A, Ghitulescu G, Faria J, Morin N, Vasilevsky C, Boutros M, Moon J, Pang A, Ghitulescu G, Faria J, Morin N, Vasilevsky C, Boutros M, Salama E, Alrashid F, Vasilevsky C, Ghitulescu G, Faria J, Morin N, Boutros M, Wiseman V, Zhang L, MacDonald P, Merchant SM, Wattie Barnett K, Caycedo-Marulanda A, Patel SV, Harra Z, Vasilevsky C, Ghitulescu G, Morin N, Boutros M, Pang A, Hegagi M, Alqahtani M, Morin N, Ghitulescu G, Vasilevsky C, Boutros M, Alghaithi N, Marinescu D, Al-Masrouri S, Pang A, Vasilevsky C, Boutros M, Papillon E, Kasteel N, Kaur G, Bindra S, Malhotra A, Graham C, MacLean A, Beck P, Jijon H, Ferraz J, Buie W, Szwimer R, Moon J, Demian M, Pang A, Morin N, Vasilevsky C, Rajabiyazdi F, Boutros M, Azin A, Merchant S, Kong W, Gyawali B, Hanna T, Chung W, Nanji S, Patel S, Booth C, Li V, Awan A, Serrano P, Jacobson M, Chanco M, Wen V, Singh N, Peiris L, Pasieka J, Ghatage P, Buie D, MacLean T, Bouchard-Fortier A, Mack L, Marini W, Zheng W, Swallow C, Reedijk M, DiPasquale A, Peiris L, Prus-Czrnecka Z, Delmar L, Gagnon N, Villiard R, Martel É, Cadrin-Chênevert A, Ledoux É, Racicot C, Mysuria S, Bazzarelli A, Pao J, Chen L, Zhang M, McKevitt E, Warburton R, Kuusk U, Van Laeken N, Bovill E, Isaac K, Dingee C, Hunter-Smith A, Cuthbert C, Fergus K, Barbera L, Efegoma Y, Howell D, Isherwood S, Levasseur N, Scheer A, Simmons C, Srikantham A, Temple-Orberle C, Xu Y, Metcalfe K, Quan M, Alqaydi A, la J, Merchant S, Digby G, Pravong V, Brind'Amour A, Sidéris L, Dubé P, De Guerke L, Fortin S, Auclair M, Trilling B, Tremblay J, Di Lena É, Hopkins B, Wong S, Meterissian S, Di Lena É, Barone N, Hopkins B, Dumitra S, Kaneva P, Fiore J, Meterissian S, Mysuria S, McKevitt E, Warburton R, Chen L, Bazzarelli A, Pao J, Bovill E, Zhang M, Kuusk U, Isaac K, Van Laeken N, Dingee C, Kapur H, McKevitt E, Warburton R, Pao J, Dingee C, Bazarelli A, Kuusk U, Chen L, Cadili L, DeGirolamo K, McKevitt E, Pao J, Dingee C, Bazzarelli A, Warburton R, Ng D, Ali A, Eymae D, Lee K, Brar S, Conner J, Magalhaes M, Swallow C, Allen K, Baliski C, Cyr D, Sari A, Messenger D, Driman D, Assarzadegan N, Juda A, Swallow C, Kennedy E, Brar M, Conner J, Kirsch R, Allard-Coutu A, Singh K, Lamontagne A, Gamache Y, Allard-Coutu A, Mardinger C, Lee C, Duckworth R, Brindle M, Fraulin F, Austen L, Kortbeek J, Hyndman M, Nguyen D, Jamjoum G, Meguerditchian A, Langer S, Yuan Xu Y, Kong S, Quan M, Lim D, Retrouvey H, Kerrebijn I, Butler K, O'Neill A, Cil T, Zhong T, Hofer S, McCready D, Metcalfe K, Lim D, Greene B, Look Hong N, Parapini M, Skipworth J, Mah A, Desai S, Chung S, Scudamore C, Segedi M, Vasilyeva E, Li J, Kim P, Verhoeff K, Deprato A, Purich K, Kung J, Bigam D, Dajani K, Lenet T, Gilbert R, Smoot R, Martel G, Tzeng C, Rocha F, Yohanathan L, Cleary S, Bertens K, Reyna-Sepulveda F, Badrudin D, Gala-Lopez B, Hanna N, Brogly S, Wei X, Booth C, Nanji S, Zuckerman J, Coburn N, Mahar A, Callum J, Kaliwal Y, Jayaraman S, Wei A, Martel G, Hallet J, Zuckerman J, Jayaraman S, Wei A, Mahar A, Kaliwal Y, Martel G, Coburn N, Hallet J, Henault D, Barrette B, Pelletier S, Thebault P, Beaudry-Simoneau E, Rong Z, Plasse M, Dagenais ARM, Létourneau R, Lapointe R, Vandenbroucke-Menu F, Nguyen B, Soucy G, Turcotte S, Lemke M, Waugh E, Leslie K, Quan D, Skaro A, Tang E, Lund M, Allen L, Glinka J, Jada G, Quan D, Skaro A, Tang E, Park L, Daza J, Li V, Msallak H, Zhang B, Workneh A, Faisal S, Faisal R, Fabbro M, Gu C, Claassen M, Zuk V, Hallet J, Martel G, Sapisochin G, Serrano P, Glinka J, Skaro A, Leslie K, Jada G, Quan D, Tang E, Waugh E, Lemke M, Glinka J, Skaro A, Leslie K, Tang E, Waugh E, Breadner D, Liu R, Tang E, Allen L, Welch S, Skaro A, Leslie K, Glinka J, Waugh E, Tang E, Jada G, Quan D, Skaro A, Webb A, Lester E, Shapiro A, Eurich D, Bigam D, Essaji Y, Shrader H, Nayyar A, Suraju M, Williams-Perez S, Ear P, Chan C, Smith V, Rivers-Bowerman M, Costa A, Stueck A, Campbell N, Allen S, Gala-Lopez B, Gilbert R, Lenet T, Cleary S, Smoot R, Tzeng C, Rocha F, Martel G, Bertens K, Mir Z, Golding H, McKeown S, Nanji S, Flemming J, Groome P, Mir Z, Djerboua M, Nanji S, Flemming J, Groome P, Elbekri S, Turcotte S, Girard E, Morency-Potvin P, Lapointe R, Vandenbroucke-Menu F, Dagenais M, Roy A, Letourneau R, Plasse M, Simoneau E, Rong Z, Zuker N, Oakley M, Chartrand G, Misheva B, Bendavid Y, Frigault J, Lemieux S, Breton D, Bouchard G, Drolet S, Melland-Smith M, Smith L, Tan J, Kahn U, McLean C, Mocanu V, Birch D, Karmali S, Switzer N, Fortin M, Paré X, Doyon A, Keshavjee S, Schwenger K, Yadav J, Fischer S, Jackson T, Allard J, Okrainec A, Lee Y, Anvari S, Chu M, Lovrics O, Aditya I, Malhan R, Khondker A, Walsh M, Doumouras A, Hong D, He W, Vergis A, Hardy K, Romanescu R, Deaninck F, Linton J, Fowler-Woods M, Fowler-Woods A, Shingoose G, Vergis A, Hardy K, Zmudzinski M, Cloutier Z, McKechnie T, Lee Y, Archer V, Doumouras A, Shiroky J, Abu Halimah J, Ramji K, Boudreau V, Mierzwa A, Mocanu V, Marcil G, Dang J, Switzer N, Birch D, Karmali S, Mierzwa A, Jarrar A, Hardy-Henry A, Kolozsvari N, Lin W, Hagen J, Connell M, Sun W, Dang J, Mocanu V, Kung J, Switzer N, Birch D, Karmali S. Can J Surg. 2021 Nov-Dec; 2021 Dec 15. PMID: 35483046.", + "Differential Effects of Neurectomy and Botox-induced Muscle Paralysis on Bone Phenotype and Titanium Implant Osseointegration. Deng J, Cohen DJ, Redden J, McClure MJ, Boyan BD, Schwartz Z. Bone. 2021 Dec; 2021 Aug 12. PMID: 34390886.", + "Using Social Media to Disseminate Effective Pain Treatments for Newborns During Needle-Related Painful Procedures in China. Hu J, Xue F, Zhou Y, Liu Y, Li Q, Deng J, Harrison D. J Perinat Neonatal Nurs. 2021 Oct-Dec 01. PMID: 34726656.", + "Ursodeoxycholic Acid Response Is Associated With Reduced Mortality in Primary Biliary Cholangitis With Compensated Cirrhosis. John BV, Khakoo NS, Schwartz KB, Aitchenson G, Levy C, Dahman B, Deng Y, Goldberg DS, Martin P, Kaplan DE, Taddei TH. Am J Gastroenterol. 2021 Sep 1. PMID: 33989225.", + "", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Kaffman Lab", + "lab_url": "https://medicine.yale.edu/lab/kaffman/", + "research_bio": "INFORMATION FOR The Kaffman lab is studying the impact of early life adversity (ELA) on neurodevelopment and complex behavior in mice. We intergare molecular, cellular, genomic, pharmacological, and behavioral approaches with imaging techniques such as resting state fMRI and high-resolution dMRI conducted in rodents. This approach allows us to directly compare our findings in rodents with those reported using similar imaging techniques in humans exposed to ELA. The objective of this translational research is to understand the molecular and cellular mechanisms by which ELA modifies the development and function of brain circuits that regulate psychiatrically relevant behaviors, and to utilize this knowledge to develop novel diagnostic and treatment modalities. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/kaffman/publications/", + "publications": [ + "Yale School of Medicine /", + "Psychiatry /", + "Research Projects", + "Contact Us", + "People and Collaborators", + "Publications", + "Videos", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research Projects", + "People and Collaborators", + "Publications", + "Videos", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Erratic Maternal Care Induces Avoidant-Like Attachment Deficits in a Mouse Model of Early Life Adversity. MacDowell Kaswan ZA, Bowers C, Teplyakov I, Sibtain A, Munoz-Martin J, Ahmed S, Kaffman L, Giuliano L, Dietrich MO, Kaffman A. eNeuro. 2025 Nov; 2025 Nov 11. PMID: 41145209.", + "The Microglial TREM2 Receptor Programs Hippocampal Development in a Mouse Model of Childhood Deprivation. Ahmed S, Bowers C, Munoz-Martin J, Jamwal S, Sanganahalli BG, Giuliano L, Kaswan ZAM, Hyder F, Yang XW, Kaffman A. bioRxiv. 2025 Aug 11; 2025 Aug 11. PMID: 40832299.", + "Erratic Maternal Care Induces Avoidant-Like Attachment Deficits in a Mouse Model of Early Life Adversity. Kaswan ZAM, Bowers C, Teplyakov I, Munoz-Martin J, Ahmed S, Kaffman L, Giuliano L, Dietrich MO, Kaffman A. bioRxiv. 2025 Jun 14; 2025 Jun 14. PMID: 40661478.", + "Transient impairment in microglial function causes sex-specific deficits in synaptic maturity and hippocampal function in mice exposed to early adversity. Ahmed S, Polis B, Jamwal S, Sanganahalli BG, MacDowell Kaswan Z, Islam R, Kim D, Bowers C, Giuliano L, Biederer T, Hyder F, Kaffman A. Brain Behav Immun. 2024 Nov; 2024 Aug 10. PMID: 39134183.", + "Postnatal Enrichment Corrects Deficits in Perineuronal Net Formation and Reversal Learning in Adult Mice Exposed to Early Adversity. Jamwal S, Islam R, Kaswan ZM, Ahmed S, Bowers C, Giuliano L, Kaffman A. bioRxiv. 2024 Sep 23; 2024 Sep 23. PMID: 39386482.", + "Microglia: The Drunken Gardeners of Early Adversity. Ahmed S, Polis B, Kaffman A. Biomolecules. 2024 Aug 8; 2024 Aug 8. PMID: 39199352.", + "Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice. Islam R, White JD, Arefin TM, Mehta S, Liu X, Polis B, Giuliano L, Ahmed S, Bowers C, Zhang J, Kaffman A. Biol Sex Differ. 2024 May 7; 2024 May 7. PMID: 38715106.", + "Transient Impairment in Microglial Function Causes Sex-Specific Deficits in Synaptic and Hippocampal Function in Mice Exposed to Early Adversity. Ahmed S, Polis B, Jamwal S, Sanganahalli BG, Kaswan ZM, Islam R, Kim D, Bowers C, Giuliano L, Biederer T, Hyder F, Kaffman A. bioRxiv. 2024 Feb 15; 2024 Feb 15. PMID: 38405887.", + "Early adversity changes the economic conditions of mouse structural brain network organization. Carozza S, Holmes J, Vértes PE, Bullmore E, Arefin TM, Pugliese A, Zhang J, Kaffman A, Akarca D, Astle DE. Dev Psychobiol. 2023 Sep. PMID: 37607894.", + "Early life stress impairs synaptic pruning in the developing hippocampus. Dayananda KK, Ahmed S, Wang D, Polis B, Islam R, Kaffman A. Brain Behav Immun. 2023 Jan; 2022 Sep 26. PMID: 36174883.", + "Macroscopic Structural and Connectome Mapping of the Mouse Brain Using Diffusion Magnetic Resonance Imaging. Arefin TM, Lee CH, White JD, Zhang J, Kaffman A. Bio Protoc. 2021 Nov 20; 2021 Nov 20. PMID: 34909442.", + "Editorial: Effects of Early Life Stress on Neurodevelopment and Health: Bridging the Gap Between Human Clinical Studies and Animal Models. Kaffman A, Herringa RJ, Sanchez MM. Front Hum Neurosci. 2021; 2021 Oct 5. PMID: 34675791.", + "Deficits in hippocampal-dependent memory across different rodent models of early life stress: systematic review and meta-analysis. Rocha M, Wang D, Avila-Quintero V, Bloch MH, Kaffman A. Transl Psychiatry. 2021 Apr 20; 2021 Apr 20. PMID: 33879774.", + "White-Matter Repair as a Novel Therapeutic Target for Early Adversity. Islam R, Kaffman A. Front Neurosci. 2021; 2021 Apr 9. PMID: 33897364.", + "The Promise of Automated Home-Cage Monitoring in Improving Translational Utility of Psychiatric Research in Rodents. Mingrone A, Kaffman A, Kaffman A. Front Neurosci. 2020; 2020 Dec 17. PMID: 33390898.", + "Early life stress causes sex-specific changes in adult fronto-limbic connectivity that differentially drive learning. White JD, Arefin TM, Pugliese A, Lee CH, Gassen J, Zhang J, Kaffman A. Elife. 2020 Dec 1; 2020 Dec 1. PMID: 33259286.", + "Systematic review and meta-analysis: effects of maternal separation on anxiety-like behavior in rodents. Wang D, Levine JLS, Avila-Quintero V, Bloch M, Kaffman A. Transl Psychiatry. 2020 Jun 1; 2020 Jun 1. PMID: 32483128.", + "Editorial Perspective: Childhood maltreatment - the problematic unisex assumption. White JD, Kaffman A. J Child Psychol Psychiatry. 2020 Jun; 2019 Dec 11. PMID: 31828779.", + "The Moderating Effects of Sex on Consequences of Childhood Maltreatment: From Clinical Studies to Animal Models. White JD, Kaffman A. Front Neurosci. 2019; 2019 Oct 10. PMID: 31680821.", + "Enhancing the Utility of Preclinical Research in Neuropsychiatry Drug Development. Kaffman A, White JD, Wei L, Johnson FK, Krystal JH. Methods Mol Biol. 2019. PMID: 31273690.", + "Early life stress perturbs the function of microglia in the developing rodent brain: New insights and future challenges. Johnson FK, Kaffman A. Brain Behav Immun. 2018 Mar; 2017 Jun 15. PMID: 28625767.", + "Amygdala hyper-connectivity in a mouse model of unpredictable early life stress. Johnson FK, Delpech JC, Thompson GJ, Wei L, Hao J, Herman P, Hyder F, Kaffman A. Transl Psychiatry. 2018 Feb 21; 2018 Feb 21. PMID: 29463821.", + "Early life stress perturbs the maturation of microglia in the developing hippocampus. Delpech JC, Wei L, Hao J, Yu X, Madore C, Butovsky O, Kaffman A. Brain Behav Immun. 2016 Oct; 2016 Jun 11. PMID: 27301858.", + "Early-life stress restricts the capacity of adult progenitor cells to differentiate into neurons. Kaffman A. Biol Psychiatry. 2015 Feb 15. PMID: 25592267.", + "Early-Life Stress Perturbs Key Cellular Programs in the Developing Mouse Hippocampus. Wei L, Hao J, Lacher RK, Abbott T, Chung L, Colangelo CM, Kaffman A. Dev Neurosci. 2015; 2015 Jun 11. PMID: 26068561.", + "Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders. Coplan JD, Fulton SL, Reiner W, Jackowski A, Panthangi V, Perera TD, Gorman JM, Huang YY, Tang CY, Hof PR, Kaffman A, Dwork AJ, Mathew SJ, Kaufman J, Mann JJ. Front Behav Neurosci. 2014; 2014 Dec 23. PMID: 25566007.", + "Early life stress inhibits expression of ribosomal RNA in the developing hippocampus. Wei L, Hao J, Kaffman A. PLoS One. 2014; 2014 Dec 17. PMID: 25517398.", + "Early life stress and macaque amygdala hypertrophy: preliminary evidence for a role for the serotonin transporter gene. Coplan JD, Fathy HM, Jackowski AP, Tang CY, Perera TD, Mathew SJ, Martinez J, Abdallah CG, Dwork AJ, Pantol G, Carpenter D, Gorman JM, Nemeroff CB, Owens MJ, Kaffman A, Kaufman J. Front Behav Neurosci. 2014; 2014 Oct 6. PMID: 25339875.", + "New frontiers in animal research of psychiatric illness. Kaffman A, Krystal JH. Methods Mol Biol. 2012. PMID: 22231804.", + "Early life stress inhibits expression of a novel innate immune pathway in the developing hippocampus. Wei L, Simen A, Mane S, Kaffman A. Neuropsychopharmacology. 2012 Jan; 2011 Oct 12. PMID: 21993208.", + "Affiliative behavior requires juvenile, but not adult neurogenesis. Wei L, Meaney MJ, Duman RS, Kaffman A. J Neurosci. 2011 Oct 5. PMID: 21976519.", + "Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates. Jackowski A, Perera TD, Abdallah CG, Garrido G, Tang CY, Martinez J, Mathew SJ, Gorman JM, Rosenblum LA, Smith EL, Dwork AJ, Shungu DC, Kaffman A, Gelernter J, Coplan JD, Kaufman J. Psychiatry Res. 2011 Apr 30; 2011 Mar 5. PMID: 21377844.", + "Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: a pilot study. Coplan JD, Abdallah CG, Kaufman J, Gelernter J, Smith EL, Perera TD, Dwork AJ, Kaffman A, Gorman JM, Rosenblum LA, Owens MJ, Nemeroff CB. Psychoneuroendocrinology. 2011 Feb; 2010 Aug 6. PMID: 20692103.", + "The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates. Coplan JD, Abdallah CG, Tang CY, Mathew SJ, Martinez J, Hof PR, Smith EL, Dwork AJ, Perera TD, Pantol G, Carpenter D, Rosenblum LA, Shungu DC, Gelernter J, Kaffman A, Jackowski A, Kaufman J, Gorman JM. Neurosci Lett. 2010 Aug 16; 2010 Jun 10. PMID: 20541590.", + "Early life stress increases anxiety-like behavior in Balb c mice despite a compensatory increase in levels of postnatal maternal care. Wei L, David A, Duman RS, Anisman H, Kaffman A. Horm Behav. 2010 Apr; 2010 Jan 22. PMID: 20096699.", + "Arguable assumptions, debatable conclusions. Kaufman J, Gelernter J, Kaffman A, Caspi A, Moffitt T. Biol Psychiatry. 2010 Feb 15; 2009 Dec 14. PMID: 20006323.", + "The silent epidemic of neurodevelopmental injuries. Kaffman A. Biol Psychiatry. 2009 Oct 1. PMID: 19747590.", + "Neurodevelopmental sequelae of postnatal maternal care in rodents: clinical and research implications of molecular insights. Kaffman A, Meaney MJ. J Child Psychol Psychiatry. 2007 Mar-Apr. PMID: 17355397.", + "Regulation of nuclear localization: a key to a door. Kaffman A, O'Shea EK. Annu Rev Cell Dev Biol. 1999. PMID: 10611964.", + "The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus. Kaffman A, Rank NM, O'Neill EM, Huang LS, O'Shea EK. Nature. 1998 Dec 3. PMID: 9853758.", + "Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121. Kaffman A, Rank NM, O'Shea EK. Genes Dev. 1998 Sep 1. PMID: 9732266.", + "Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex. O'Neill EM, Kaffman A, Jolly ER, O'Shea EK. Science. 1996 Jan 12. PMID: 8539622.", + "Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85. Kaffman A, Herskowitz I, Tjian R, O'Shea EK. Science. 1994 Feb 25. PMID: 8108735.", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Kahle Lab", + "lab_url": "https://medicine.yale.edu/lab/kahle/", + "research_bio": "INFORMATION FOR Our research is devoted to identifying and characterizing the genes and signaling pathways in the nervous system that regulate ion flux and water homeostasis to impact epithelial transport, cell volume regulation, and neuronal excitability. We also explore how genetically-encoded or maladaptive changes in these genes contribute to human neurological diseases, including hydrocephalus, cerebral edema, and seizures. We necessarily employ a multidisciplinary approach that includes genetics (next generation sequencing of human patients, mouse genetics, and functional genomic screening), physiology, and biochemistry (including phospho-proteomics). A particular focus of the lab is devoted to the study of the functional regulation of the SLC12A family cation-Cl- cotransporters. Our efforts are grounded on the principle that the molecular genetic study of rare Mendelian forms of human disease, and even individual patients, can identity critical nodes within complex physiological pathways that might serve as drug targets for more common forms of these diseases. The overarching goal of our work is to translate advances in basic science into novel therapeutic strategies for the precision care of individual pediatric neurosurgical patients. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/kahle/publications", + "publications": null + }, + { + "lab_name": "Kallen Lab", + "lab_url": "https://medicine.yale.edu/lab/kallen/", + "research_bio": "INFORMATION FOR The Kallen Lab’s research program aims improve our understanding of the regulatory mechanisms underlying follicular development and reproductive aging in the mammalian ovary. Over the last several years, noncoding RNAs (ncRNAs) have emerged as master regulators of tissue growth and differentiation, and my work has focused on these ncRNAs and their role in the reproductive tract. During her Reproductive Endocrinology and Infertility fellowship, Dr. Kallen was awarded a position in the NICHD’s Reproductive Scientist Development Program (RSDP), a prestigious mentored career development program whose goal is to develop academic reproductive physician-scientists equipped with the skills to address important problems in the field of obstetrics and gynecology. This was a transformative experience, allowing Dr. Kallen to use her background as a physician to better understand reproduction at the cellular and molecular level, as well as to understand the importance of research that could translate from bench to bedside. Dr. Kallen's published work inMolecular Cell, demonstrating that the ncRNA H19 acts as a molecular “sponge” for the micro RNA let-7, was completed under the guidance of her RSDP mentor, Dr. Yingqun Huang and been cited nearly 600 times. More recently, the Kallen lab described novel, noncoding-RNA-mediated mechanisms for regulation of follicular recruitment as well as for the rate-limiting step of steroidogenesis; the latter resulted in a manuscript which was recognized by the Endocrine Society as one of the \"Top Endocrine Discoveries of 2017\". Since completion of the RSDP, Dr. Kallen received the American Society for Reproductive Medicine Research Grant and the 2020 Society for Reproductive Investigation “Early Career Investigator” Award for her work on mechanisms of reproductive aging. Dr. Kallen is currently the PI on an R01 which aims to investigate noncoding RNA-mediated regulation of ovarian follicular quantity and quality, a novel and understudied area of ovarian aging, and which received an Impact Score of 10 (1st percentile). Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Kang Lab", + "lab_url": "https://medicine.yale.edu/lab/kang/", + "research_bio": "INFORMATION FOR Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/kang/pubs/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Pulmonary, Critical Care & Sleep Medicine /", + "Research", + "Publications", + "Members", + "Contact Us", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Publications", + "Members", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Eosinophilia Is a Favorable Marker for Pneumonia in Chronic Obstructive Pulmonary Disease. Gu KM, Jung JW, Kang MJ, Kim DK, Choi H, Cho YJ, Jang SH, Lee CH, Oh YM, Park JS, Kim JY. Tuberc Respir Dis (Seoul). 2024 Oct; 2024 May 3. PMID: 38710525.", + "The serotype-specific prevalence of pneumococci in hospitalized pneumonia patients with COPD: a prospective, multi-center, cohort study. Kim JY, Jung JW, Kang MJ, Kim DK, Choi H, Cho YJ, Jang SH, Lee CH, Oh YM, Park JS. Korean J Intern Med. 2023 Sep; 2023 Aug 17. PMID: 37586811.", + "VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis. Kim SH, Adams TS, Hu Q, Shin HJ, Chae G, Lee SE, Sharma L, Kwon HK, Lee FY, Park HJ, Huh WJ, Manning E, Kaminski N, Sauler M, Chen L, Song JW, Kim TK, Kang MJ. Am J Respir Cell Mol Biol. 2023 Jul. PMID: 36450109.", + "Genomic analysis of plasma circulating tumor DNA in patients with heavily pretreated HER2 + metastatic breast cancer. Lee K, Lee J, Choi J, Sim SH, Kim JE, Kim MH, Park YH, Kim JH, Koh SJ, Park KH, Kang MJ, Ahn MS, Lee KE, Kim HJ, Ahn HK, Kim HJ, Park KU, Park IH. Sci Rep. 2023 Jun 19; 2023 Jun 19. PMID: 37336919.", + "NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury. Kim HR, Kim MN, Kim EG, Leem JS, Baek SM, Lee YJ, Kim KW, Kang MJ, Song TW, Sohn MH. Sci Rep. 2023 Mar 1; 2023 Mar 1. PMID: 36859435.", + "Coronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction. Peng X, Kim J, Gupta G, Agaronyan K, Mankowski MC, Korde A, Takyar SS, Shin HJ, Habet V, Voth S, Audia JP, Chang D, Liu X, Wang L, Cai Y, Tian X, Ishibe S, Kang MJ, Compton S, Wilen CB, Dela Cruz CS, Sharma L. J Immunol. 2022 Oct 1; 2022 Sep 2. PMID: 36165196.", + "Epidermal Growth Factor Receptor Inhibition Is Protective in Hyperoxia-Induced Lung Injury. Harris ZM, Sun Y, Joerns J, Clark B, Hu B, Korde A, Sharma L, Shin HJ, Manning EP, Placek L, Unutmaz D, Stanley G, Chun H, Sauler M, Rajagopalan G, Zhang X, Kang MJ, Koff JL. Oxid Med Cell Longev. 2022; 2022 Sep 20. PMID: 36193076.", + "Distinct Roles of Type I and Type III Interferons during a Native Murine β Coronavirus Lung Infection. Sharma L, Peng X, Qing H, Hilliard BK, Kim J, Swaminathan A, Tian J, Israni-Winger K, Zhang C, Habet V, Wang L, Gupta G, Tian X, Ma Y, Shin HJ, Kim SH, Kang MJ, Ishibe S, Young LH, Kotenko S, Compton S, Wilen CB, Wang A, Dela Cruz CS. J Virol. 2022 Jan 26; 2021 Oct 27. PMID: 34705554.", + "Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19. Kamle S, Ma B, He CH, Akosman B, Zhou Y, Lee CM, El-Deiry WS, Huntington K, Liang O, Machan JT, Kang MJ, Shin HJ, Mizoguchi E, Lee CG, Elias JA. JCI Insight. 2021 Nov 8; 2021 Nov 8. PMID: 34747367.", + "Nucleotide-binding domain and leucine-rich-repeat-containing protein X1 deficiency induces nicotinamide adenine dinucleotide decline, mechanistic target of rapamycin activation, and cellular senescence and accelerates aging lung-like changes. Shin HJ, Kim SH, Park HJ, Shin MS, Kang I, Kang MJ. Aging Cell. 2021 Jul; 2021 Jun 4. PMID: 34087956.", + "Macrophage-preferable delivery of the leucine-rich repeat domain of NLRX1 ameliorates lethal sepsis by regulating NF-κB and inflammasome signaling activation. Koo JH, Kim SH, Jeon SH, Kang MJ, Choi JM. Biomaterials. 2021 Jul; 2021 May 4. PMID: 33971559.", + "PINK1 Inhibits Multimeric Aggregation and Signaling of MAVS and MAVS-Dependent Lung Pathology. Kim SH, Shin HJ, Yoon CM, Lee SW, Sharma L, Dela Cruz CS, Kang MJ. Am J Respir Cell Mol Biol. 2021 May. PMID: 33577398.", + "Mitochondrial antiviral signaling protein is crucial for the development of pulmonary fibrosis. Kim SH, Lee JY, Yoon CM, Shin HJ, Lee SW, Rosas I, Herzog E, Dela Cruz CS, Kaminski N, Kang MJ. Eur Respir J. 2021 Apr; 2021 Apr 15. PMID: 33093124.", + "Hospitalization increases while economic status deteriorates in late stages of chronic obstructive pulmonary disease: the Korean National Health and Nutrition Examination Survey for 2007-2015. Kang HK, Jung JW, Kang MJ, Kim DK, Choi H, Cho YJ, Jang SH, Lee CH, Oh YM, Park J, Kim JY. J Thorac Dis. 2021 Apr. PMID: 34012566.", + "Smoking Alters Inflammation and Skeletal Stem and Progenitor Cell Activity During Fracture Healing in Different Murine Strains. Hao Z, Li J, Li B, Alder KD, Cahill SV, Munger AM, Lee I, Kwon HK, Back J, Xu S, Kang MJ, Lee FY. J Bone Miner Res. 2021 Jan; 2020 Sep 24. PMID: 32866293.", + "Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergetics. Blumental-Perry A, Jobava R, Bederman I, Degar AJ, Kenche H, Guan BJ, Pandit K, Perry NA, Molyneaux ND, Wu J, Prendergas E, Ye ZW, Zhang J, Nelson CE, Ahangari F, Krokowski D, Guttentag SH, Linden PA, Townsend DM, Miron A, Kang MJ, Kaminski N, Perry Y, Hatzoglou M. Commun Biol. 2020 Oct 30; 2020 Oct 30. PMID: 33127975.", + "Fecal microbial transplantation and a high fiber diet attenuates emphysema development by suppressing inflammation and apoptosis. Jang YO, Lee SH, Choi JJ, Kim DH, Choi JM, Kang MJ, Oh YM, Park YJ, Shin Y, Lee SW. Exp Mol Med. 2020 Jul; 2020 Jul 17. PMID: 32681029.", + "Recent Advances in Molecular Basis of Lung Aging and Its Associated Diseases. Kang MJ. Tuberc Respir Dis (Seoul). 2020 Apr; 2020 Mar 10. PMID: 32185913.", + "LRR domain of NLRX1 protein delivery by dNP2 inhibits T cell functions and alleviates autoimmune encephalomyelitis. Koo JH, Kim DH, Cha D, Kang MJ, Choi JM. Theranostics. 2020; 2020 Feb 10. PMID: 32194859.", + "Impact of Cigarette Smoke Exposure on the Lung Fibroblastic Response after Influenza Pneumonia. Lee SW, Sharma L, Kang YA, Kim SH, Chandrasekharan S, Losier A, Brady V, Bermejo S, Andrews N, Yoon CM, Liu W, Lee JY, Kang MJ, Dela Cruz CS. Am J Respir Cell Mol Biol. 2018 Dec. PMID: 30110182.", + "Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases. Dela Cruz CS, Kang MJ. Mitochondrion. 2018 Jul; 2017 Dec 6. PMID: 29221810.", + "Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis. Kim DH, Park HJ, Lim S, Koo JH, Lee HG, Choi JO, Oh JH, Ha SJ, Kang MJ, Lee CM, Lee CG, Elias JA, Choi JM. Nat Commun. 2018 Feb 5; 2018 Feb 5. PMID: 29403003.", + "A Mitochondrial Perspective of Chronic Obstructive Pulmonary Disease Pathogenesis. Kang MJ, Shadel GS. Tuberc Respir Dis (Seoul). 2016 Oct; 2016 Oct 5. PMID: 27790272.", + "Mitochondrial Regulation of Inflammasome Activation in Chronic Obstructive Pulmonary Disease. Yoon CM, Nam M, Oh YM, Dela Cruz CS, Kang MJ. J Innate Immun. 2016; 2015 Nov 5. PMID: 26536345.", + "Role of Chitinase 3-Like-1 in Interleukin-18-Induced Pulmonary Type 1, Type 2, and Type 17 Inflammation; Alveolar Destruction; and Airway Fibrosis in the Murine Lung. Kang MJ, Yoon CM, Nam M, Kim DH, Choi JM, Lee CG, Elias JA. Am J Respir Cell Mol Biol. 2015 Dec. PMID: 25955511.", + "MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury. Mannam P, Shinn AS, Srivastava A, Neamu RF, Walker WE, Bohanon M, Merkel J, Kang MJ, Dela Cruz CS, Ahasic AM, Pisani MA, Trentalange M, West AP, Shadel GS, Elias JA, Lee PJ. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1; 2014 Jan 31. PMID: 24487387.", + "Role of ribonuclease L in viral pathogen-associated molecular pattern/influenza virus and cigarette smoke-induced inflammation and remodeling. Zhou Y, Kang MJ, Jha BK, Silverman RH, Lee CG, Elias JA. J Immunol. 2013 Sep 1; 2013 Aug 2. PMID: 23913960.", + "IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension. Cho WK, Lee CM, Kang MJ, Huang Y, Giordano FJ, Lee PJ, Trow TK, Homer RJ, Sessa WC, Elias JA, Lee CG. Am J Physiol Lung Cell Mol Physiol. 2013 Jan 15; 2012 Nov 2. PMID: 23125252.", + "Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary fibrosis. Zhou Y, Lee JY, Lee CM, Cho WK, Kang MJ, Koff JL, Yoon PO, Chae J, Park HO, Elias JA, Lee CG. J Biol Chem. 2012 Dec 7; 2012 Oct 19. PMID: 23086930.", + "IL-18 induces emphysema and airway and vascular remodeling via IFN-γ, IL-17A, and IL-13. Kang MJ, Choi JM, Kim BH, Lee CM, Cho WK, Choe G, Kim DH, Lee CG, Elias JA. Am J Respir Crit Care Med. 2012 Jun 1; 2012 Mar 1. PMID: 22383501.", + "Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema. Matsuura H, Hartl D, Kang MJ, Dela Cruz CS, Koller B, Chupp GL, Homer RJ, Zhou Y, Cho WK, Elias JA, Lee CG. Am J Respir Cell Mol Biol. 2011 Jun; 2010 Jul 23. PMID: 20656949.", + "RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism. Ma B, Dela Cruz CS, Hartl D, Kang MJ, Takyar S, Homer RJ, Lee CG, Elias JA. Am J Respir Crit Care Med. 2011 May 15; 2011 Jan 28. PMID: 21278304.", + "Transgenic modelling of cytokine polarization in the lung. Dela Cruz CS, Kang MJ, Cho WK, Lee CG. Immunology. 2011 Jan; 2010 Nov 23. PMID: 21091906.", + "Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury. Lee CG, Da Silva CA, Dela Cruz CS, Ahangari F, Ma B, Kang MJ, He CH, Takyar S, Elias JA. Annu Rev Physiol. 2011. PMID: 21054166.", + "Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice. Kang MJ, Lee CG, Lee JY, Dela Cruz CS, Chen ZJ, Enelow R, Elias JA. J Clin Invest. 2008 Aug. PMID: 18654661.", + "IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. Kang MJ, Homer RJ, Gallo A, Lee CG, Crothers KA, Cho SJ, Rochester C, Cain H, Chupp G, Yoon HJ, Elias JA. J Immunol. 2007 Feb 1. PMID: 17237446.", + "IFN-gamma-dependent DNA injury and/or apoptosis are critical in cigarette smoke-induced murine emphysema. Kang MJ, Lee CG, Cho SJ, Homer RJ, Elias JA. Proc Am Thorac Soc. 2006 Aug. PMID: 16921135.", + "State of the art. Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice. Elias JA, Kang MJ, Crothers K, Homer R, Lee CG. Proc Am Thorac Soc. 2006 Aug. PMID: 16921126.", + "Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling. Cho SJ, Kang MJ, Homer RJ, Kang HR, Zhang X, Lee PJ, Elias JA, Lee CG. J Biol Chem. 2006 Mar 24; 2006 Jan 26. PMID: 16439363.", + "Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema. Ma B, Kang MJ, Lee CG, Chapoval S, Liu W, Chen Q, Coyle AJ, Lora JM, Picarella D, Homer RJ, Elias JA. J Clin Invest. 2005 Dec; 2005 Nov 10. PMID: 16284650.", + "Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. Zheng T, Kang MJ, Crothers K, Zhu Z, Liu W, Lee CG, Rabach LA, Chapman HA, Homer RJ, Aldous D, De Sanctis GT, Underwood S, Graupe M, Flavell RA, Schmidt JA, Elias JA. J Immunol. 2005 Jun 15. PMID: 15944319.", + "Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM, Elias JA. Nat Med. 2004 Oct; 2004 Sep 19. PMID: 15378055.", + "Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. Lee CG, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, Yehualaeshet T, Lu B, Flavell RA, Milbrandt J, Homer RJ, Elias JA. J Exp Med. 2004 Aug 2. PMID: 15289506.", + "The Anlyan Center for Medical Research & Education 300 Cedar Street New Haven, CT 06510", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Karam Lab", + "lab_url": "https://medicine.yale.edu/lab/karam/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Katz Lab", + "lab_url": "https://medicine.yale.edu/lab/katz/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Kibbey Lab", + "lab_url": "https://medicine.yale.edu/lab/kibbey/", + "research_bio": "INFORMATION FOR Mitochondria, as the primary sites of consumption and production of metabolites and energy, are central to regulation of insulin secretion, glucose production, nerve transmission, muscular contraction and normal and cancer cell growth. Mitochondria, therefore, require mechanisms to ‘sense’ their own metabolic environment in order to efficiently respond to supply and demand termed ‘metabolic equilibrioception.’ In order to better understand these and other important mitochondrial metabolic fluxes, methods to discriminate between oxidative, exchange, anaplerotic, and cataplerotic fluxes were developed. Consequently, the LC/MS/MS method Mass Isotopomeric Multi-Ordinate Spectroscopic Analysis (MIMOSA) follows the step-wise flow of mass isotopomers along these intersecting metabolic pathways. It captures both steady state and dynamic metabolic fluxes by resolving positional isotopomers of the TCA cycle. As a consequence, MIMOSA not only can determine the rates of individual intracellular fluxes but, when more than one pathway compete for a reaction, the relative flow of each contribution. From the study of a rare condition of congenital hypoglycemia, the Kibbey lab identified mitochondrial GTP (mtGTP) as an important equilibrioceptive indicator involved in glucose homeostasis and ascribed the first physiological activity of the mitochondria GTP cycle as a “metabolic tachometer.” In tissues such as pancreatic ß-cells and hepatocytes, the mtGTP is hydrolyzed by the mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK-M) to generate PEP that is essential for insulin secretion, while in hepatocytes it catalyzes this crucial step of gluconeogenesis. Finally, it also regulates glucagon secretion from a-cells. The Kibbey Lab has developed a unique experience with mitochondrial, cellular, tissues-specific and whole-body metabolism needed to advance mtGTP understanding. It is strongly vested in both understanding intracellular and inter-tissue metabolic flux associated with metabolic human disease. Differences in equilibrioception and responses to pharmacologic therapy are used to identify defects in metabolism as novel therapeutic targets for humans. The lab focuses mostly on 13C mass spectrometry, insulin resistance and secretion, bioenergetics, and applications to cellular, cancer and animal preclinical models. Copy Link Yale School of Medicine300 Cedar Street, Ste S110New Haven, CT 06519 Lab Phone: 203-785-7228 Email:kibbey.lab@yale.edu Copy Link The Kibbey Laboratory is a part of the Department ofInternal Medicine/Endocrinology, theDepartment of Cellular and Molecular Physiology, theDiabetes Research Center (DRC)and theYale Cancer Center. Dr. Kibbey also practices medicine atYale University Health ServicesandYale New Haven Hospital. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/kibbey/publications/", + "publications": null + }, + { + "lab_name": "Kim Laboratory", + "lab_url": "https://medicine.yale.edu/lab/kim/", + "research_bio": "INFORMATION FOR Copy Link Brain hemorrhages, traumatic brain injury, and strokes are devastating injuries that instantly change the lives not only of the affected individual but also their family and friends. Even worse, some individuals continue to suffer complications from their injuries either in the hospital, like with delayed strokes, or years later, like with epilepsy. Our lab is focused on investigating how to predict the individuals that are at greatest risk for these additional – or “secondary” – complications, so that we can ultimately develop treatments to prevent them from happening. Our research focuses on integrating multimodal data, including early EEG and MRI biomarkers, that improve prediction of short- and long-term complications after severe acute brain injuries, such as subarachnoid hemorrhage, brain trauma, and ischemic stroke. We are applying novel computational methods to the data gathered within the neurologic intensive care unit to predict patients who are at high risk for further injury. Our goal is to use these predictions to optimize treatment strategies that prevent these complications. Copy Link Dr. Jennifer Kim is recruiting a Research Associate to join her critical care neurophysiology group. We are interested in all aspects of the management of patients with brain trauma and other acute neurologic injuries, novel biomarkers, and imaging techniques for brain injury, neurologic outcome assessments, and more. To be considered for the position, please complete the Google form application. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/kim/publications/", + "publications": [ + "Yale School of Medicine /", + "Neurology /", + "Research", + "People", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "", + "", + "", + "", + "", + "", + "National Versus State-Level Racial Disparities in Acute Stroke Interventions Using Get With The Guidelines-Stroke Data. Kim JA, Herman A, Shrader P, Alhanti B, Xian Y, Falcone GJ, Mac Grory B, Smith EE, Messe SR, de Havenon A, Fonarow GC, Sheth KN. Stroke. 2025 Oct; 2025 Aug 20. PMID: 40832710.", + "Dual-outcome Prediction of Post-Ischemic Stroke Epilepsy and Mortality Using Multimodal Quantitative Biomarkers. Chen Y, Soto AL, Sudhakar TD, Zubair A, Sun H, Jing J, Ge W, Loman L, Sivaraju A, Petersen N, Hirsch LJ, Blumenfeld H, Zafar SF, Struck AF, Sheth KN, Gilmore EJ, Westover MB, Kim JA. medRxiv. 2025 Sep 27; 2025 Sep 27. PMID: 41040677.", + "Treatment Effect of Early Intravenous Milrinone for Cerebral Vasospasm or Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage. Baang HY, Reynolds AS, Dangayach NS, Gilmore EJ, Kim JA, Lay C. Neurocrit Care. 2025 Aug; 2025 May 6. PMID: 40329063.", + "Polygenic Risk of Epilepsy and Poststroke Epilepsy. Clocchiatti-Tuozzo S, Rivier CA, Misra S, Zelano J, Mazumder R, Sansing LH, de Havenon A, Hirsch LJ, Liebeskind DS, Gilmore EJ, Sheth KN, Kim JA, Worrall BB, Falcone GJ, Mishra NK. Stroke. 2024 Dec; 2024 Nov 6. PMID: 39502073.", + "Antiseizure Medication Withdrawal, Risk of Epilepsy, and Longterm EEG Trends in Acute Symptomatic Seizures or Epileptic EEG Patterns. Sivaraju A, Tao A, Jadav R, Kirunda KN, Rampal N, Kim JA, Gilmore EJ, Hirsch LJ. Neurol Clin Pract. 2024 Dec; 2024 Aug 16. PMID: 39185097.", + "Impact of Therapeutic Interventions on Cerebral Autoregulatory Function Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study. Prasad A, Gilmore EJ, Kim JA, Begunova L, Olexa M, Beekman R, Falcone GJ, Matouk C, Ortega-Gutierrez S, Temkin NR, Barber J, Diaz-Arrastia R, de Havenon A, Petersen NH. Neurocrit Care. 2024 Aug; 2023 Dec 29. PMID: 38158481.", + "Prognostic Implications of Early Prediction in Posttraumatic Epilepsy. Chen Y, Cappucci SP, Kim JA. Semin Neurol. 2024 Jun; 2024 Apr 15. PMID: 38621706.", + "Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG Interpretation. Jing J, Ge W, Hong S, Fernandes MB, Lin Z, Yang C, An S, Struck AF, Herlopian A, Karakis I, Halford JJ, Ng MC, Johnson EL, Appavu BL, Sarkis RA, Osman G, Kaplan PW, Dhakar MB, Arcot Jayagopal L, Sheikh Z, Taraschenko O, Schmitt S, Haider HA, Kim JA, Swisher CB, Gaspard N, Cervenka MC, Rodriguez Ruiz AA, Lee JW, Tabaeizadeh M, Gilmore EJ, Nordstrom K, Yoo JY, Holmes MG, Herman ST, Williams JA, Pathmanathan J, Nascimento FA, Fan Z, Nasiri S, Shafi MM, Cash SS, Hoch DB, Cole AJ, Rosenthal ES, Zafar SF, Sun J, Westover MB. Neurology. 2023 Apr 25; 2023 Mar 6. PMID: 36878708.", + "Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs. Jing J, Ge W, Struck AF, Fernandes MB, Hong S, An S, Fatima S, Herlopian A, Karakis I, Halford JJ, Ng MC, Johnson EL, Appavu BL, Sarkis RA, Osman G, Kaplan PW, Dhakar MB, Jayagopal LA, Sheikh Z, Taraschenko O, Schmitt S, Haider HA, Kim JA, Swisher CB, Gaspard N, Cervenka MC, Rodriguez Ruiz AA, Lee JW, Tabaeizadeh M, Gilmore EJ, Nordstrom K, Yoo JY, Holmes MG, Herman ST, Williams JA, Pathmanathan J, Nascimento FA, Fan Z, Nasiri S, Shafi MM, Cash SS, Hoch DB, Cole AJ, Rosenthal ES, Zafar SF, Sun J, Westover MB. Neurology. 2023 Apr 25; 2022 Dec 2. PMID: 36460472.", + "Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Ammar AA, Elsamadicy AA, Ammar MA, Reeves BC, Koo AB, Falcone GJ, Hwang DY, Petersen N, Kim JA, Beekman R, Prust M, Magid-Bernstein J, Acosta JN, Herbert R, Sheth KN, Matouk CC, Gilmore EJ. Clin Neurol Neurosurg. 2023 Mar; 2023 Feb 9. PMID: 36791588.", + "Quantitative epileptiform burden and electroencephalography background features predict post-traumatic epilepsy. Chen Y, Li S, Ge W, Jing J, Chen HY, Doherty D, Herman A, Kaleem S, Ding K, Osman G, Swisher CB, Smith C, Maciel CB, Alkhachroum A, Lee JW, Dhakar MB, Gilmore EJ, Sivaraju A, Hirsch LJ, Omay SB, Blumenfeld H, Sheth KN, Struck AF, Edlow BL, Westover MB, Kim JA. J Neurol Neurosurg Psychiatry. 2023 Mar; 2022 Oct 14. PMID: 36241423.", + "Automated EEG-based prediction of delayed cerebral ischemia after subarachnoid hemorrhage. Zheng WL, Kim JA, Elmer J, Zafar SF, Ghanta M, Moura Junior V, Patel A, Rosenthal E, Brandon Westover M. Clin Neurophysiol. 2022 Nov; 2022 Sep 11. PMID: 36182752.", + "Deep Learning Applications for Acute Stroke Management. Chavva IR, Crawford AL, Mazurek MH, Yuen MM, Prabhat AM, Payabvash S, Sze G, Falcone GJ, Matouk CC, de Havenon A, Kim JA, Sharma R, Schiff SJ, Rosen MS, Kalpathy-Cramer J, Iglesias Gonzalez JE, Kimberly WT, Sheth KN. Ann Neurol. 2022 Oct; 2022 Jul 20. PMID: 35689531.", + "Epileptiform activity predicts epileptogenesis in cerebral hemorrhage. Kong THJ, Abdul Azeem M, Naeem A, Allen S, Kim JA, Struck AF. Ann Clin Transl Neurol. 2022 Sep; 2022 Aug 27. PMID: 36030385.", + "High epileptiform discharge burden predicts delayed cerebral ischemia after subarachnoid hemorrhage. Kim JA, Zheng WL, Elmer J, Jing J, Zafar SF, Ghanta M, Moura V Junior, Gilmore EJ, Hirsch LJ, Patel A, Rosenthal E, Westover MB. Clin Neurophysiol. 2022 Sep; 2021 Mar 10. PMID: 33812771.", + "Development and Validation of a Model to Identify Critical Brain Injuries Using Natural Language Processing of Text Computed Tomography Reports. Torres-Lopez VM, Rovenolt GE, Olcese AJ, Garcia GE, Chacko SM, Robinson A, Gaiser E, Acosta J, Herman AL, Kuohn LR, Leary M, Soto AL, Zhang Q, Fatima S, Falcone GJ, Payabvash MS, Sharma R, Struck AF, Sheth KN, Westover MB, Kim JA. JAMA Netw Open. 2022 Aug 1; 2022 Aug 1. PMID: 35972739.", + "The coronal plane maximum diameter of deep intracerebral hemorrhage predicts functional outcome more accurately than hematoma volume. Haider SP, Qureshi AI, Jain A, Tharmaseelan H, Berson ER, Majidi S, Filippi CG, Mak A, Werring DJ, Acosta JN, Malhotra A, Kim JA, Sansing LH, Falcone GJ, Sheth KN, Payabvash S. Int J Stroke. 2022 Aug; 2021 Oct 13. PMID: 34569877.", + "Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest. Beekman R, Crawford A, Mazurek MH, Prabhat AM, Chavva IR, Parasuram N, Kim N, Kim JA, Petersen N, de Havenon A, Khosla A, Honiden S, Miller PE, Wira C, Daley J, Payabvash S, Greer DM, Gilmore EJ, Taylor Kimberly W, Sheth KN. Resuscitation. 2022 Jul; 2022 May 11. PMID: 35562094.", + "Impact of Frailty on Morbidity and Mortality in Adult Patients Undergoing Surgical Evacuation of Acute Traumatic Subdural Hematoma. Elsamadicy AA, Sandhu MRS, Freedman IG, Koo AB, Reeves BC, Yu J, Hengartner A, Havlik J, Hong CS, Rutherford HJV, Kim JA, Gerrard J, Gilmore EJ, Omay SB. World Neurosurg. 2022 Jun; 2022 Mar 9. PMID: 35276399.", + "Antiseizure Medication Treatment and Outcomes in Patients with Subarachnoid Hemorrhage Undergoing Continuous EEG Monitoring. Zafar SF, Rosenthal ES, Postma EN, Sanches P, Ayub MA, Rajan S, Kim JA, Rubin DB, Lee H, Patel AB, Hsu J, Patorno E, Westover MB. Neurocrit Care. 2022 Jun; 2021 Nov 29. PMID: 34843082.", + "Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke. Yuen MM, Prabhat AM, Mazurek MH, Chavva IR, Crawford A, Cahn BA, Beekman R, Kim JA, Gobeske KT, Petersen NH, Falcone GJ, Gilmore EJ, Hwang DY, Jasne AS, Amin H, Sharma R, Matouk C, Ward A, Schindler J, Sansing L, de Havenon A, Aydin A, Wira C, Sze G, Rosen MS, Kimberly WT, Sheth KN. Sci Adv. 2022 Apr 22; 2022 Apr 20. PMID: 35442729.", + "The Utility of Quantitative EEG in Detecting Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage. Baang HY, Chen HY, Herman AL, Gilmore EJ, Hirsch LJ, Sheth KN, Petersen NH, Zafar SF, Rosenthal ES, Westover MB, Kim JA. J Clin Neurophysiol. 2022 Mar 1. PMID: 34510093.", + "International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke. Mishra NK, Engel J Jr, Liebeskind DS, Sharma VK, Hirsch LJ, Kasner SE, French JA, Devinsky O, Friedman A, Dawson J, Quinn TJ, Selim M, de Havenon A, Yasuda CL, Cendes F, Benninger F, Zaveri HP, Burneo JG, Srivastava P, Bhushan Singh M, Bhatia R, Vishnu VY, Bentes C, Ferro J, Weiss S, Sivaraju A, Kim JA, Galovic M, Gilmore EJ, Pitkänen A, Davis K, Sansing LH, Sheth KN, Paz JT, Singh A, Sheth S, Worrall BB, Grotta JC, Casillas-Espinos PM, Chen Z, Nicolo JP, Yan B, Kwan P. Epilepsy Behav. 2022 Feb; 2021 Dec 27. PMID: 34968775.", + "Combining Transcranial Doppler and EEG Data to Predict Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. Chen HY, Elmer J, Zafar SF, Ghanta M, Moura Junior V, Rosenthal ES, Gilmore EJ, Hirsch LJ, Zaveri HP, Sheth KN, Petersen NH, Westover MB, Kim JA. Neurology. 2022 Feb 1; 2021 Nov 29. PMID: 34845057.", + "Bedside detection of intracranial midline shift using portable magnetic resonance imaging. Sheth KN, Yuen MM, Mazurek MH, Cahn BA, Prabhat AM, Salehi S, Shah JT, By S, Welch EB, Sofka M, Sacolick LI, Kim JA, Payabvash S, Falcone GJ, Gilmore EJ, Hwang DY, Matouk C, Gordon-Kundu B, Rn AW, Petersen N, Schindler J, Gobeske KT, Sansing LH, Sze G, Rosen MS, Kimberly WT, Kundu P. Sci Rep. 2022 Jan 7; 2022 Jan 7. PMID: 34996970.", + "Hospital Revisits for Post-Ischemic Stroke Epilepsy after Acute Stroke Interventions. Kuohn LR, Herman AL, Soto AL, Brown SC, Gilmore EJ, Hirsch LJ, Matouk CC, Sheth KN, Kim JA. J Stroke Cerebrovasc Dis. 2022 Jan; 2021 Oct 21. PMID: 34688213.", + "Focused Management of Patients With Severe Acute Brain Injury and ARDS. Kim JA, Wahlster S, LaBuzetta JN, Nobleza COS, Johnson NJ, Rubinos C, Malaiyandi D, O'Phelan KH, Mainali S, Sarwal A, Gilmore EJ. Chest. 2022 Jan; 2021 Sep 25. PMID: 34506794.", + "Association of Posttraumatic Epilepsy With 1-Year Outcomes After Traumatic Brain Injury. Burke J, Gugger J, Ding K, Kim JA, Foreman B, Yue JK, Puccio AM, Yuh EL, Sun X, Rabinowitz M, Vassar MJ, Taylor SR, Winkler EA, Deng H, McCrea M, Stein MB, Robertson CS, Levin HS, Dikmen S, Temkin NR, Barber J, Giacino JT, Mukherjee P, Wang KKW, Okonkwo DO, Markowitz AJ, Jain S, Lowenstein D, Manley GT, Diaz-Arrastia R, Badjatia N, Duhaime AC, Feeser VR, Gaudette E, Gopinath S, Keene CD, Korley FK, Madden C, Merchant R, Schnyer D, Zafonte R. JAMA Netw Open. 2021 Dec 1; 2021 Dec 1. PMID: 34964854.", + "Electroencephalography, Hospital Complications, and Longitudinal Outcomes After Subarachnoid Hemorrhage. Lissak IA, Locascio JJ, Zafar SF, Schleicher RL, Patel AB, Leslie-Mazwi T, Stapleton CJ, Koch MJ, Kim JA, Anderson K, Rosand J, Westover MB, Kimberly WT, Rosenthal ES. Neurocrit Care. 2021 Oct; 2021 Jan 22. PMID: 33483913.", + "Admission computed tomography radiomic signatures outperform hematoma volume in predicting baseline clinical severity and functional outcome in the ATACH-2 trial intracerebral hemorrhage population. Haider SP, Qureshi AI, Jain A, Tharmaseelan H, Berson ER, Zeevi T, Majidi S, Filippi CG, Iseke S, Gross M, Acosta JN, Malhotra A, Kim JA, Sansing LH, Falcone GJ, Sheth KN, Payabvash S. Eur J Neurol. 2021 Sep; 2021 Jul 18. PMID: 34189814.", + "Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhage. Mazurek MH, Cahn BA, Yuen MM, Prabhat AM, Chavva IR, Shah JT, Crawford AL, Welch EB, Rothberg J, Sacolick L, Poole M, Wira C, Matouk CC, Ward A, Timario N, Leasure A, Beekman R, Peng TJ, Witsch J, Antonios JP, Falcone GJ, Gobeske KT, Petersen N, Schindler J, Sansing L, Gilmore EJ, Hwang DY, Kim JA, Malhotra A, Sze G, Rosen MS, Kimberly WT, Sheth KN. Nat Commun. 2021 Aug 25; 2021 Aug 25. PMID: 34433813.", + "A model of metabolic supply-demand mismatch leading to secondary brain injury. Song JL, Kim JA, Struck AF, Zhang R, Westover MB. J Neurophysiol. 2021 Aug 1; 2021 Jul 7. PMID: 34232754.", + "Vessel wall MRI in ruptured cranial dural arteriovenous fistulas. Cord BJ, Renedo D, Santarosa C, Sujijantarat N, Antonios J, Kim JA, Falcone GJ, Sheth KN, Malhotra A, Matouk CC. Interv Neuroradiol. 2021 Aug; 2021 Jan 11. PMID: 33430655.", + "Electroencephalographic Abnormalities are Common in COVID-19 and are Associated with Outcomes. Lin L, Al-Faraj A, Ayub N, Bravo P, Das S, Ferlini L, Karakis I, Lee JW, Mukerji SS, Newey CR, Pathmanathan J, Abdennadher M, Casassa C, Gaspard N, Goldenholz DM, Gilmore EJ, Jing J, Kim JA, Kimchi EY, Ladha HS, Tobochnik S, Zafar S, Hirsch LJ, Westover MB, Shafi MM. Ann Neurol. 2021 May; 2021 Mar 24. PMID: 33704826.", + "Holding Out Hope After Traumatic Brain Injury. Kim JA, Sheth KN. JAMA Neurol. 2021 May 1. PMID: 33646278.", + "Deep active learning for Interictal Ictal Injury Continuum EEG patterns. Ge W, Jing J, An S, Herlopian A, Ng M, Struck AF, Appavu B, Johnson EL, Osman G, Haider HA, Karakis I, Kim JA, Halford JJ, Dhakar MB, Sarkis RA, Swisher CB, Schmitt S, Lee JW, Tabaeizadeh M, Rodriguez A, Gaspard N, Gilmore E, Herman ST, Kaplan PW, Pathmanathan J, Hong S, Rosenthal ES, Zafar S, Sun J, Brandon Westover M. J Neurosci Methods. 2021 Mar 1; 2020 Oct 22. PMID: 33131680.", + "Association of race and ethnicity to incident epilepsy, or epileptogenesis, after subdural hematoma. Brown SC, King ZA, Kuohn L, Kamel H, Gilmore EJ, Frontera JA, Murthy S, Kim JA, Omay SB, Falcone GJ, Sheth KN. Neurology. 2020 Nov 24; 2020 Sep 9. PMID: 32907969.", + "Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients. Sheth KN, Mazurek MH, Yuen MM, Cahn BA, Shah JT, Ward A, Kim JA, Gilmore EJ, Falcone GJ, Petersen N, Gobeske KT, Kaddouh F, Hwang DY, Schindler J, Sansing L, Matouk C, Rothberg J, Sze G, Siner J, Rosen MS, Spudich S, Kimberly WT. JAMA Neurol. 2020 Sep 8; 2020 Sep 8. PMID: 32897296.", + "Detecting Seizures and Epileptiform Abnormalities in Acute Brain Injury. Singla S, Garcia GE, Rovenolt GE, Soto AL, Gilmore EJ, Hirsch LJ, Blumenfeld H, Sheth KN, Omay SB, Struck AF, Westover MB, Kim JA. Curr Neurol Neurosci Rep. 2020 Jul 27; 2020 Jul 27. PMID: 32715371.", + "Soluble ST2 Is Associated With New Epileptiform Abnormalities Following Nontraumatic Subarachnoid Hemorrhage. Lissak IA, Zafar SF, Westover MB, Schleicher RL, Kim JA, Leslie-Mazwi T, Stapleton CJ, Patel AB, Kimberly WT, Rosenthal ES. Stroke. 2020 Apr; 2020 Mar 11. PMID: 32156203.", + "Development of Expert-Level Automated Detection of Epileptiform Discharges During Electroencephalogram Interpretation. Jing J, Sun H, Kim JA, Herlopian A, Karakis I, Ng M, Halford JJ, Maus D, Chan F, Dolatshahi M, Muniz C, Chu C, Sacca V, Pathmanathan J, Ge W, Dauwels J, Lam A, Cole AJ, Cash SS, Westover MB. JAMA Neurol. 2020 Jan 1. PMID: 31633740.", + "Maps & Directions", + "Calendar", + "Contact Us", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Kleinstein Lab", + "lab_url": "https://medicine.yale.edu/lab/kleinstein/", + "research_bio": "INFORMATION FOR We are a computational immunology group with a combination of \"big data\" analysis and immunology domain expertise. Our interests include both developingnew computational methodsand applying these methods to study human immune responses. Specific areas of focus include: We are always open to new collaboration opportunities with basic science and clinical research groups. Pleasesend us an emailif interested. For research updates, follow us on twitter (@skleinstein).Read more about our research Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Kluger Lab", + "lab_url": "https://medicine.yale.edu/lab/kluger/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/kluger/publications/", + "publications": [ + "Yale School of Medicine /", + "Pathology /", + "Research", + "Contact", + "People", + "News", + "Publications", + "Software PCA and SVD software", + "PCA and SVD software", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "Software", + "Contact", + "News", + "", + "", + "", + "", + "", + "", + "C. Zhang, B. Balbo, M. Ma, J. Zhao, X. Tian, Y. Kluger, and S. Somlo, \" Cyclin-Dependent Kinase 1 Activity Is a Driver of Cyst Growth in Polycystic Kidney Disease ,\" Journal of the American Society of Nephrology, vol. 32, pp. 41-51, 2021.", + "E. Sefik, B. Israelow, J. Zhao, R. Qu, E. Song, H. Mirza, E. Kaffe, S. Halene, E. Meffre, and Y. Kluger, \" A humanized mouse model of chronic COVID-19 to evaluate disease mechanisms and treatment options ,\" 2021.", + "M. S. B. Raredon, J. Yang, J. Garritano, M. Wang, D. Kushnir, J. C. Schupp, T. S. Adams, A. M. Greaney, K. L. Leiby, N. Kaminski, Y. Kluger, A. Levchenko, and L. E. Niklason, \" Connectome: computation and visualization of cell-cell signaling topologies in single-cell systems data ,\" bioRxiv, p. 2021.01.21.427529, 2021.", + "T. Qing, H. Mohsen, V. L. Cannataro, M. Marczyk, M. Rozenblit, J. Foldi, M. F. Murray, J. P. Townsend, Y. Kluger, and M. Gerstein, \" Cancer relevance of human genes ,\" bioRxiv, 2021.", + "Lindenbaum, N. Nouri, Y. Kluger, and S. H. Kleinstein, \" Alignment free identification of clones in B cell receptor repertoires ,\" Nucleic Acids Res, vol. 49, p. e21, Feb 26 2021.", + "Y.-W. E. Lin, T. Shnitzer, R. Talmon, F. Villarroel-Espindola, S. Desai, K. Schalper, and Y. Kluger, \" Graph of graphs analysis for multiplexed data with application to imaging mass cytometry ,\" PLOS Computational Biology, vol. 17, p. e1008741, 2021.", + "B. Landa, T. T. Zhang, and Y. Kluger, \" Biwhitening Reveals the Rank of a Count Matrix ,\" arXiv preprint arXiv:2103.13840, 2021.", + "B. Landa, R. R. Coifman, and Y. Kluger, \" Doubly Stochastic Normalization of the Gaussian Kernel Is Robust to Heteroskedastic Noise ,\" SIAM Journal on Mathematics of Data Science, pp. 388-413, 2021/01/01 2021.", + "A. Jaffe, N. Amsel, Y. Aizenbud, B. Nadler, J. T. Chang, and Y. Kluger, \" Spectral Neighbor Joining for Reconstruction of Latent Tree Models ,\" SIAM Journal on Mathematics of Data Science, vol. 3, pp. 113-141, 2021.", + "Y. Aizenbud, A. Jaffe, M. Wang, A. Hu, N. Amsel, B. Nadler, J. T. Chang, and Y. Kluger, \" Spectral Top-Down Recovery of Latent Tree Models ,\" arXiv preprint arXiv:2102.13276, 2021.", + "J. Zhao, A. Jaffe, H. Li, O. Lindenbaum, E. Sefik, R. Jackson, X. Cheng, R. Flavell, and Y. Kluger, \" Detection of differentially abundant cell subpopulations discriminates biological states in scRNA-seq data ,\" bioRxiv, p. 711929, 2020.", + "H. Zhang, H. Zhu, G. Deng, C. R. Zito, V. O. Oria, C. K. Rane, S. Zhang, S. A. Weiss, T. Tran, A. Adeniran, F. Zhang , J. Zhou, Y. Kluger, M. W. Bosenberg , H. M. Kluger, and L. B. Jilaveanu, \" PLEKHA5 regulates tumor growth in metastatic melanoma ,\" Cancer, vol. 126, pp. 1016-1030, 2020.", + "Y. Yamada, O. Lindenbaum, S. Negahban, and Y. Kluger, \" Feature selection using stochastic gates ,\" in International Conference on Machine Learning, 2020, pp. 10648-10659.", + "M. Roulis, A. Kaklamanos, M. Schernthanner, P. Bielecki, J. Zhao, E. Kaffe, L. S. Frommelt, R. Qu, M. S. Knapp, A. Henriques, N. Chalkidi, V. Koliaraki, J. Jiao, J. R. Brewer, M. Bacher, H. N. Blackburn, X. Zhao, R. M. Breyer, V. Aidinis, D. Jain, B. Su, H. R. Herschman, Y. Kluger, G. Kollias, and R. A. Flavell, \" Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche ,\" Nature, vol. 580, pp. 524-529, Apr 2020.", + "T. Qing, H. Mohsen, M. Marczyk, Y. Ye, T. O’Meara, H. Zhao, J. P. Townsend, M. Gerstein, T. Qing, H. Mohsen, M. Marczyk, Y. Ye, T. O’Meara, H. Zhao, J. P. Townsend, M. Gerstein, C. Hatzis, Y. Kluger, and L. Pusztai, \" Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden ,\" Nature communications, vol. 11, pp. 1-8, 2020.", + "M. Marczyk, G. A. Patwardhan, J. Zhao, R. Qu, X. Li, V. B. Wali, A. K. Gupta, M. M. Pillai, Y. Kluger, Q. Yan, C. Hatzis, L. Pusztai, and V. Gunasekharan, \" Multi-Omics Investigation of Innate Navitoclax Resistance in Triple-Negative Breast Cancer Cells ,\" Cancers, vol. 12, p. 2551, 2020.", + "Lindenbaum, U. Shaham, J. Svirsky, E. Peterfreund, and Y. Kluger, \" Let the Data Choose its Features: Differentiable Unsupervised Feature Selection ,\" arXiv preprint arXiv:2007.04728, 2020.", + "Lindenbaum, M. Salhov, A. Averbuch, and Y. Kluger, \" Deep Gated Canonical Correlation Analysis ,\" arXiv preprint arXiv:2010.05620, 2020.", + "B. Landa, R. Qu, J. Chang, and Y. Kluger, \" Local Two-Sample Testing over Graphs and Point-Clouds by Random-Walk Distributions ,\" arXiv preprint arXiv:2011.03418, 2020.", + "D. M. Kluger, Y. Aizenbud, A. Jaffe, F. Parisi, L. Aizenbud, E. Minsky-Fenick, J. M. Kluger, S. Farhadian, H. M. Kluger, and Y. Kluger, \" Impact of healthcare worker shift scheduling on workforce preservation during the COVID-19 pandemic ,\" Infection Control & Hospital Epidemiology, vol. 41, pp. 1443-1445, 2020.", + "A.Jarret, R. Jackson, C. Duizer, M. E. Healy, J. Zhao, J. M. Rone, P. Bielecki, E. Sefik, M. Roulis, T. Rice, K. N. Sivanathan, T. Zhou, A. G. Solis, H. Honcharova-Biletska, K. Vélez, S. Hartner, J. S. Low, R. Qu, M. R. de Zoete, N. W. Palm, A. M. Ring, A. Weber, A. E. Moor, Y. Kluger, R. Nowarski, and R. A. Flavell, \" Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity ,\" Cell, vol. 180, pp. 50-63.e12, 2020/01/09/ 2020.", + "A. Jaffe, Y. Kluger, G. C. Linderman, G. Mishne, and S. Steinerberger, \" Randomized near-neighbor graphs, giant components and applications in data science ,\" Journal of applied probability, vol. 57, pp. 458-476, 2020.", + "A. Jaffe, Y. Kluger, O. Lindenbaum, J. Patsenker, E. Peterfreund, and S. Steinerberger, \" The Spectral Underpinning of word2vec ,\" Frontiers in Applied Mathematics and Statistics, vol. 6, 2020-December-03 2020.", + "S. B. Goldberg, K. A. Schalper, S. N. Gettinger, A. Mahajan, R. S. Herbst, A. C. Chiang, R. Lilenbaum, F. H. Wilson, S. B. Omay, J. B. Yu, L. Jilaveanu, T. Tran, K. Pavlik, E. Rowen, H. Gerrish, A. Komlo, R. Gupta, H. Wyatt, M. Ribeiro, Y. Kluger, G. Zhou, W. Wei, V. L. Chiang, and H. M. Kluger, \" Pembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial ,\" The Lancet Oncology, vol. 21, pp. 655-663, 2020/05/01/ 2020.", + "M. C. Amezcua Vesely, P. Pallis, P. Bielecki, J. S. Low, J. Zhao, C. C. D. Harman, L. Kroehling, R. Jackson, W. Bailis, P. Licona-Limon, H. Xu, N. Iijima, P. S. Pillai, D. H. Kaplan, C. T. Weaver, Y. Kluger, M. S. Kowalczyk, A. Iwasaki, J. P. Pereira, E. Esplugues, N. Gagliani, and R. A. Flavell, \" Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection ,\" Cell, vol. 178, pp. 1176-1188 e15, Aug 22 2019.", + "Z. Wang, M. D. Gearhart, Y. W. Lee, I. Kumar, B. Ramazanov, Y. Zhang, C. Hernandez, A. Y. Lu, N. Neuenkirchen, J. Deng, J. Jin, Y. Kluger, T. A. Neubert, V. J. Bardwell, and N. B. Ivanova, \" A Non-canonical BCOR-PRC1.1 Complex Represses Differentiation Programs in Human ESCs ,\" Cell Stem Cell, vol. 22, pp. 235-251 e9, Feb 1 2018.", + "M. S. B. Raredon, T. S. Adams, Y. Suhail, J. C. Schupp, S. Poli, N. Neumark, K. L. Leiby, A. M. Greaney, Y. Yuan, C. Horien, G. Linderman, A. J. Engler, D. J. Boffa, Y. Kluger, I. O. Rosas, A. Levchenko, N. Kaminski, and L. E. Niklason, \" Single-cell connectomic analysis of adult mammalian lungs ,\" Sci Adv, vol. 5, p. eaaw3851, Dec 2019.", + "G. C. Linderman, M. Rachh, J. G. Hoskins, S. Steinerberger, and Y. Kluger, \" Fast interpolation-based t-SNE for improved visualization of single-cell RNA-seq data ,\" Nature methods, vol. 16, p. 243, 2019.", + "D. T. Li, G. C. Linderman, J. J. Cui, S. DeVries, A. D. Nicholson, E. Li, L. Petit, J. B. Kahan, R. Talty, Y. Kluger, D. R. Cooperman, and B. G. Smith, \" The Proximal Humeral Ossification System Improves Assessment of Maturity in Patients with Scoliosis ,\" J Bone Joint Surg Am, vol. 101, pp. 1868-1874, Oct 16 2019.", + "A. Lahav, R. Talmon, and Y. Kluger, \" Mahalanobis distance informed by clustering ,\" Information and Inference: A Journal of the IMA, vol. 8, pp. 377-406, 2019.", + "D. Kobak, G. Linderman, S. Steinerberger, Y. Kluger, and P. Berens, \" Heavy-tailed kernels reveal a finer cluster structure in t-SNE visualisations ,\" in Joint European Conference on Machine Learning and Knowledge Discovery in Databases, 2019, pp. 124-139.", + "H. M. Kluger, V. Chiang, A. Mahajan, C. R. Zito, M. Sznol, T. Tran, S. A. Weiss, J. V. Cohen, J. Yu, and U. Hegde, \" Long-term survival of patients with melanoma with active brain metastases treated with pembrolizumab on a phase II trial ,\" Journal of Clinical Oncology, vol. 37, p. 52, 2019.", + "L. Irshaid, E. Weinberger, J. Garritano, J. Patsenker, Y. Kluger, S. Katz, and M. Xu, \" Histopathologic and Machine Deep Learning Criteria to Predict Lymphoma Transformation in Bone Marrow Biopsies ,\" in LABORATORY INVESTIGATION, 2019.", + "K. Gupta, J. Levinsohn, G. Linderman, D. Chen, T. Y. Sun, D. Dong, M. M. Taketo, M. Bosenberg, Y. Kluger, K. Choate, and P. Myung, \" Single-Cell Analysis Reveals a Hair Follicle Dermal Niche Molecular Differentiation Trajectory that Begins Prior to Morphogenesis,\" Dev Cell , vol. 48, pp. 17-31 e6, Jan 7 2019.", + "D. E. Carvajal-Hausdorf, J. Patsenker, K. P. Stanton, F. Villarroel-Espindola, A. Esch, R. R. Montgomery, A. Psyrri, K. T. Kalogeras, V. Kotoula, G. Foutzilas, K. A. Schalper, Y. Kluger, and D. L. Rimm, \" Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry ,\" Clin Cancer Res, vol. 25, pp. 3054-3062, May 15 2019.", + "W. Bailis, J. A. Shyer, J. Zhao, J. C. G. Canaveras, F. J. Al Khazal, R. Qu, H. R. Steach, P. Bielecki, O. Khan, R. Jackson, Y. Kluger, L. J. Maher, 3rd, J. Rabinowitz, J. Craft, and R. A. Flavell, \" Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function ,\" Nature, vol. 571, pp. 403-407, Jul 2019.", + "Y. Yamada, O. Lindenbaum, S. Negahban, and Y. Kluger, \" Feature Selection using Stochastic Gates ,\" in Proceedings of the 37 th International Conference on Machine Learning, Vienna, Austria, PMLR 119, 2020, 2018.", + "D. Ueno, Z. Xie, M. Boeke, J. Syed, K. A. Nguyen, P. McGillivray, A. Adeniran, P. Humphrey, G. M. Dancik, Y. Kluger, Z. Liu, H. Kluger, and B. Shuch, \" Genomic Heterogeneity and the Small Renal Mass ,\" Clin Cancer Res, vol. 24, pp. 4137-4144, Sep 1 2018.", + "U. Shaham, K. Stanton, H. Li, R. Basri, B. Nadler, and Y. Kluger, \" SpectralNet: Spectral Clustering using Deep Neural Networks ,\" in International Conference on Learning Representations, 2018.", + "U. Shaham, J. Garritano, Y. Yamada, E. Weinberger, A. Cloninger, X. Cheng, K. Stanton, and Y. Kluger, \" Defending against adversarial images using basis functions transformations ,\" arXiv preprint arXiv:1803.10840, 2018.", + "G. C. Linderman, J. Zhao, and Y. Kluger, \" Zero-preserving imputation of scRNA-seq data using low-rank approximation ,\" bioRxiv, p. 397588, 2018.", + "H. Li, Y. Kluger, and M. Tygert, \" Randomized algorithms for distributed computation of principal component analysis and singular value decomposition ,\" Advances in Computational Mathematics, vol. 44, pp. 1651-1672, 2018.", + "J. L. Katzman, U. Shaham, A. Cloninger, J. Bates, T. Jiang, and Y. Kluger, \" DeepSurv: personalized treatment recommender system using a Cox proportional hazards deep neural network ,\" BMC Med Res Methodol, vol. 18, p. 24, Feb 26 2018.", + "A. Jaffe, R. Weiss, B. Nadler, S. Carmi, and Y. Kluger, \" Learning Binary Latent Variable Models: A Tensor Eigenpair Approach ,\" presented at the Proceedings of the 35th International Conference on Machine Learning, Proceedings of Machine Learning Research, 2018.", + "D. Herndler-Brandstetter, H. Ishigame, R. Shinnakasu, V. Plajer, C. Stecher, J. Zhao, M. Lietzenmayer, L. Kroehling, A. Takumi, K. Kometani, T. Inoue, Y. Kluger, S. M. Kaech, T. Kurosaki, T. Okada, and R. A. Flavell, \"KLRG1(+) Effector CD8(+) T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity ,\" Immunity, vol. 48, pp. 716-729 e8, Apr 17 2018.", + "S. Zhu, S. Ding, P. Wang, Z. Wei, W. Pan, N. W. Palm, Y. Yang, H. Yu, H. B. Li, G. Wang, X. Lei, M. R. de Zoete, J. Zhao, Y. Zheng, H. Chen, Y. Zhao, K. A. Jurado, N. Feng, L. Shan, Y. Kluger, J. Lu, C. Abraham, E. Fikrig, H. B. Greenberg, and R. A. Flavell, \" Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells ,\" Nature, vol. 546, pp. 667-670, Jun 29 2017.", + "K. P. Stanton, J. Jin, R. R. Lederman, S. M. Weissman, and Y. Kluger, \" Ritornello: high fidelity control-free chromatin immunoprecipitation peak calling ,\" Nucleic acids research, vol. 45, pp. e173-e173, 2017.", + "U. Shaham, K. P. Stanton, J. Zhao, H. Li, K. Raddassi, R. Montgomery, and Y. Kluger, \" Removal of batch effects using distribution-matching residual networks ,\" Bioinformatics, vol. 33, pp. 2539-2546, 2017.", + "G. Mishne, R. Talmon, I. Cohen, R. R. Coifman, and Y. Kluger, \" Data-driven tree transforms and metrics ,\" IEEE transactions on signal and information processing over networks, vol. 4, pp. 451-466, 2017.", + "H. B. Li, J. Tong, S. Zhu, P. J. Batista, E. E. Duffy, J. Zhao, W. Bailis, G. Cao, L. Kroehling, Y. Chen, G. Wang, J. P. Broughton, Y. G. Chen, Y. Kluger, M. D. Simon, H. Y. Chang, Z. Yin, and R. A. Flavell, \" m(6)A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways ,\" Nature, vol. 548, pp. 338-342, Aug 17 2017.", + "H. Li, U. Shaham, K. P. Stanton, Y. Yao, R. R. Montgomery, and Y. Kluger, \" Gating mass cytometry data by deep learning ,\" Bioinformatics, vol. 33, pp. 3423-3430, 2017.", + "H. Li, G. C. Linderman, A. Szlam, K. P. Stanton, Y. Kluger, and M. Tygert, \" Algorithm 971: An implementation of a randomized algorithm for principal component analysis ,\" ACM Transactions on Mathematical Software (TOMS), vol. 43, pp. 1-14, 2017.", + "H. M. Kluger, C. R. Zito, G. Turcu, M. K. Baine, H. Zhang, A. Adeniran, M. Sznol, D. L. Rimm, Y. Kluger, L. Chen, J. V. Cohen, and L. B. Jilaveanu, \" PD-L1 Studies Across Tumor Types, Its Differential Expression and Predictive Value in Patients Treated with Immune Checkpoint Inhibitors ,\" Clin Cancer Res, vol. 23, pp. 4270-4279, Aug 1 2017.", + "Dror, B. Nadler, E. Bilal, and Y. Kluger, \" Unsupervised ensemble regression ,\" arXiv preprint arXiv:1703.02965, 2017.", + "T. Jiang, U. Shaham, F. Parisi, R. Halaban, A. Safonov, H. Kluger, S. Weissman, J. Chang, and Y. Kluger, \" Methods for detecting co-mutated pathways in cancer samples to inform treatment selection ,\" bioRxiv, p. 082552, 2016.", + "M. Vassilakopoulou, F. Parisi, S. Siddiqui, A. M. England, E. R. Zarella, V. Anagnostou, Y. Kluger, D. G. Hicks, D. L. Rimm, and V. M. Neumeister, \" Preanalytical variables and phosphoepitope expression in FFPE tissue: quantitative epitope assessment after variable cold ischemic time ,\" Laboratory investigation, vol. 95, pp. 334-341, 2015.", + "B. Shuch, R. Falbo, F. Parisi, A. Adeniran, Y. Kluger, H. M. Kluger, and L. B. Jilaveanu, \" MET expression in primary and metastatic clear cell renal cell carcinoma: implications of correlative biomarker assessment to MET pathway inhibitors ,\" BioMed research international, vol. 2015, 2015.", + "M. Murtha, F. Strino, Z. Tokcaer-Keskin, N. Sumru Bayin, D. Shalabi, X. Xi, Y. Kluger, and L. Dailey, \" Comparative FAIRE-seq Analysis Reveals Distinguishing Features of the Chromatin Structure of Ground State-and Primed-Pluripotent Cells ,\" Stem Cells, vol. 33, pp. 378-391, 2015.", + "L. B. Jilaveanu, F. Parisi, M. L. Barr, C. R. Zito, W. Cruz-Munoz, R. S. Kerbel, D. L. Rimm, M. W. Bosenberg, R. Halaban, Y. Kluger, and H. M. Kluger, \" PLEKHA5 as a Biomarker and Potential Mediator of Melanoma Brain Metastasis ,\" Clin Cancer Res, vol. 21, pp. 2138-47, May 1 2015.", + "Y. J. Jeon, S. Khelifa, B. Ratnikov, D. A. Scott, Y. Feng, F. Parisi, C. Ruller, E. Lau, H. Kim, L. M. Brill, T. Jiang, D. L. Rimm, R. D. Cardiff, G. B. Mills, J. W. Smith, A. L. Osterman, Y. Kluger, and Z. A. Ronai, \" Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies ,\" Cancer Cell, vol. 27, pp. 354-69, Mar 9 2015.", + "A. Jaffe, B. Nadler, and Y. Kluger, \" Estimating the accuracies of multiple classifiers without labeled data ,\" in Artificial Intelligence and Statistics, 2015, pp. 407-415.", + "F. Parisi, F. Strino, B. Nadler, and Y. Kluger, \" Ranking and combining multiple predictors without labeled data ,\" Proceedings of the National Academy of Sciences, vol. 111, pp. 1253-1258, 2014.", + "V. M. Neumeister, F. Parisi, A. M. England, S. Siddiqui, V. Anagnostou, E. Zarrella, M. Vassilakopolou, Y. Bai, S. Saylor, A. Sapino, Y. Kluger, D. G. Hicks, G. Bussolati, S. Kwei, and D. L. Rimm, \" A tissue quality index: an intrinsic control for measurement of effects of preanalytical variables on FFPE tissue ,\" Lab Invest, vol. 94, pp. 467-74, Apr 2014.", + "M. Murtha, Z. Tokcaer-Keskin, Z. Tang, F. Strino, X. Chen, Y. Wang, X. Xi, C. Basilico, S. Brown, R. Bonneau, Y. Kluger, and L. Dailey, \" FIREWACh: high-throughput functional detection of transcriptional regulatory modules in mammalian cells ,\" Nat Methods, vol. 11, pp. 559-65, May 2014.", + "L. K. Kim, E. Esplugues, C. E. Zorca, F. Parisi, Y. Kluger, T. H. Kim, N. J. Galjart, and R. A. Flavell, \" Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells ,\" Molecular cell, vol. 54, pp. 56-66, 2014.", + "L. Jilaveanu, B. Shuch, C. Zito, F. Parisi, M. Barr, Y. Kluger, L. Chen, and H. Kluger, \" PD-L1 expression in clear cell renal cell carcinoma: an analysis of nephrectomy and sites of metastases ,\" Journal of Cancer, vol. 5, p. 166, 2014.", + "T. Jiang, W. Shi, R. Natowicz, S. N. Ononye, V. B. Wali, Y. Kluger, L. Pusztai, and C. Hatzis, \" Statistical measures of transcriptional diversity capture genomic heterogeneity of cancer ,\" BMC genomics, vol. 15, pp. 1-11, 2014.", + "E. Giesen, L. B. Jilaveanu, F. Parisi, Y. Kluger, R. L. Camp, and H. M. Kluger, \" NY-ESO-1 as a potential immunotherapeutic target in renal cell carcinoma ,\" Oncotarget, vol. 5, p. 5209, 2014.", + "Y. Dong, J.-A. Richards, R. Gupta, P. Aung, A. Emley, Y. Kluger, S. Dogra, M. Mahalingam, and N. Wajapeyee, \" PTEN functions as a melanoma tumor suppressor by promoting host immune response ,\" Oncogene, vol. 33, pp. 4632-4642, 2014.", + "R. Bonasio, E. Lecona, V. Narendra, P. Voigt, F. Parisi, Y. Kluger, and D. Reinberg, \" Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes ,\" Elife, vol. 3, p. e02637, 2014.", + "J. Zhang, R. Bonasio, F. Strino, Y. Kluger, J. K. Holloway, A. J. Modzelewski, P. E. Cohen, and D. Reinberg, \" SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors ,\" Genes & development, vol. 27, pp. 749-766, 2013.", + "F. Strino, F. Parisi, M. Micsinai, and Y. Kluger, \" TrAp: a tree approach for fingerprinting subclonal tumor composition ,\" Nucleic Acids Research, vol. 41, p. e165, 2013.", + "K. P. Stanton, F. Parisi, F. Strino, N. Rabin, P. Asp, and Y. Kluger, \" Arpeggio: harmonic compression of ChIP-seq data reveals protein-chromatin interaction signatures ,\" Nucleic acids research, vol. 41, pp. e161-e161, 2013.", + "J. Chaumeil, M. Micsinai, P. Ntziachristos, D. B. Roth, I. Aifantis, Y. Kluger, L. Deriano, and J. A. Skok, \" The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage ,\" Nature communications, vol. 4, pp. 1-10, 2013.", + "J. Chaumeil, M. Micsinai, P. Ntziachristos, L. Deriano, J. M. Wang, Y. Ji, E. P. Nora, M. J. Rodesch, J. A. Jeddeloh, I. Aifantis, Y. Kluger, D. G. Schatz, and J. A. Skok, \" Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers ,\" Cell Rep, vol. 3, pp. 359-70, Feb 21 2013.", + "S. A. Aziz, J. A. Sznol, A. Adeniran, F. Parisi, Y. Kluger, R. L. Camp, and H. M. Kluger, \" Expression of drug targets in primary and matched metastatic renal cell carcinoma tumors ,\" BMC clinical pathology, vol. 13, pp. 1-9, 2013.", + "P. P. Rocha, M. Micsinai, J. R. Kim, S. L. Hewitt, P. P. Souza, T. Trimarchi, F. Strino, F. Parisi, Y. Kluger, and J. A. Skok, \" Close proximity to Igh is a contributing factor to AID-mediated translocations ,\" Molecular cell, vol. 47, pp. 873-885, 2012.", + "F. Parisi, M. Micsinai, F. Strino, S. Ariyan, D. Narayan, A. Bacchiocchi, E. Cheng, F. Xu, P. Li, H. Kluger, R. Halaban, and Y. Kluger, \" Integrated analysis of tumor samples sheds light on tumor heterogeneity ,\" Yale J Biol Med, vol. 85, pp. 347-61, Sep 2012.", + "V. M. Neumeister, V. Anagnostou, S. Siddiqui, A. M. England, E. R. Zarrella, M. Vassilakopoulou, F. Parisi, Y. Kluger, D. G. Hicks, and D. L. Rimm, \" Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues ,\" JNCI: Journal of the National Cancer Institute, vol. 104, pp. 1815-1824, 2012.", + "M. Micsinai, F. Parisi, F. Strino, P. Asp, B. D. Dynlacht, and Y. Kluger, \" Picking ChIP-seq peak detectors for analyzing chromatin modification experiments ,\" Nucleic acids research, vol. 40, pp. e70-e70, 2012.", + "K. Johnson, J. Chaumeil, M. Micsinai, J. M. H. Wang, L. B. Ramsey, G. V. Baracho, R. C. Rickert, F. Strino, Y. Kluger, M. A. Farrar, and J. A. Skok, \" IL-7 Functionally Segregates the Pro-B Cell Stage by Regulating Transcription of Recombination Mediators across Cell Cycle ,\" The Journal of Immunology, vol. 188, p. 6084, 2012.", + "Z. Gao, J. Zhang, R. Bonasio, F. Strino, A. Sawai, F. Parisi, Y. Kluger, and D. Reinberg, \" PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes ,\" Molecular cell, vol. 45, pp. 344-356, 2012.", + "F. Strino, F. Parisi, and Y. Kluger, \" VDA, a method of choosing a better algorithm with fewer validations ,\" PloS one, vol. 6, p. e26074, 2011.", + "F. Parisi, S. Ariyan, D. Narayan, A. Bacchiocchi, K. Hoyt, E. Cheng, F. Xu, P. Li, R. Halaban, and Y. Kluger, \" Detecting copy number status and uncovering subclonal markers in heterogeneous tumor biopsies ,\" BMC genomics, vol. 12, pp. 1-14, 2011.", + "H. M. Kluger, K. Hoyt, A. Bacchiocchi, T. Mayer, J. Kirsch, Y. Kluger, M. Sznol, S. Ariyan, A. Molinaro, and R. Halaban, \" Plasma markers for identifying patients with metastatic melanoma ,\" Clinical Cancer Research, vol. 17, pp. 2417-2425, 2011.", + "A. Collins, S. L. Hewitt, J. Chaumeil, M. Sellars, M. Micsinai, J. Allinne, F. Parisi, E. P. Nora, D. J. Bolland, A. E. Corcoran, Y. Kluger, R. Bosselut, W. Ellmeier, M. M. Chong, D. R. Littman, and J. A. Skok, \" RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation ,\" Immunity, vol. 34, pp. 303-14, Mar 25 2011.", + "P. Asp, R. Blum, V. Vethantham, F. Parisi, M. Micsinai, J. Cheng, C. Bowman, Y. Kluger, and B. D. Dynlacht, \" Genome-wide remodeling of the epigenetic landscape during myogenic differentiation ,\" Proceedings of the National Academy of Sciences, vol. 108, pp. E149-E158, 2011.", + "C. van Oevelen, C. Bowman, J. Pellegrino, P. Asp, J. Cheng, F. Parisi, M. Micsinai, Y. Kluger, A. Chu, A. Blais, G. David, and B. D. Dynlacht, \" The mammalian Sin3 proteins are required for muscle development and sarcomere specification ,\" Mol Cell Biol, vol. 30, pp. 5686-97, Dec 2010.", + "F. Parisi, A. M. González, Y. Nadler, R. L. Camp, D. L. Rimm, H. M. Kluger, and Y. Kluger, \" Benefits of biomarker selection and clinico-pathological covariate inclusion in breast cancer prognostic models ,\" Breast Cancer Research, vol. 12, pp. 1-11, 2010.", + "Y. Nadler, A. Gonzalez, R. Camp, D. Rimm, H. Kluger, and Y. Kluger, \" Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer ,\" Annals of oncology, vol. 21, pp. 466-473, 2010.", + "R. Halaban, W. Zhang, A. Bacchiocchi, E. Cheng, F. Parisi, S. Ariyan, M. Krauthammer, J. P. McCusker, Y. Kluger, and M. Sznol, \" PLX4032, a selective BRAFV600E kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAFWT melanoma cells ,\" Pigment cell & melanoma research, vol. 23, pp. 190-200, 2010.", + "R. Halaban, M. Krauthammer, M. Pelizzola, E. Cheng, D. Kovacs, M. Sznol, S. Ariyan, D. Narayan, A. Bacchiocchi, A. Molinaro, Y. Kluger, M. Deng, N. Tran, W. Zhang, M. Picardo, and J. J. Enghild, \" Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications ,\" PLoS One, vol. 4, p. e4563, 2009.", + "S. A. Aziz, M. Davies, E. Pick, C. Zito, L. Jilaveanu, R. L. Camp, D. L. Rimm, Y. Kluger, and H. M. Kluger, \" Phosphatidylinositol-3-kinase as a therapeutic target in melanoma ,\" Clinical Cancer Research, vol. 15, pp. 3029-3036, 2009.", + "C. van Oevelen, J. Wang, P. Asp, Q. Yan, W. G. Kaelin Jr, Y. Kluger, and B. D. Dynlacht, \" A role for mammalian Sin3 in permanent gene silencing ,\" Molecular cell, vol. 32, pp. 359-370, 2008.", + "Y. Nadler, R. L. Camp, C. Schwartz, D. L. Rimm, H. M. Kluger, and Y. Kluger, \" Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer ,\" Clinical cancer research, vol. 14, pp. 4455-4462, 2008.", + "Y. Nadler, R. L. Camp, J. M. Giltnane, C. Moeder, D. L. Rimm, H. M. Kluger, and Y. Kluger, \" Expression patterns and prognostic value of Bag-1 and Bcl-2 in breast cancer ,\" Breast Cancer Research, vol. 10, pp. 1-12, 2008.", + "M. McCarthy, E. Pick, Y. Kluger, B. Gould-Rothberg, R. Lazova, R. Camp, D. Rimm, and H. Kluger, \"HSP90 as a marker of progression in melanoma,\" Annals of oncology, vol. 19, pp. 590-594, 2008. https://www.sciencedirect.com/science/article/pii/S0923753419411885", + "A. N. Kluger, D. Nir, and Y. Kluger, \" Personal Position Repertoire (PPR) from a Bird's Eye View ,\" Journal of Constructivist Psychology, vol. 21, pp. 223-238, 2008/06/03 2008.", + "Y. Zhou, J. Ferguson, J. T. Chang, and Y. Kluger, \" Inter-and intra-combinatorial regulation by transcription factors and microRNAs ,\" BMC genomics, vol. 8, pp. 1-10, 2007.", + "E. Pick, Y. Kluger, J. M. Giltnane, C. Moeder, R. L. Camp, D. L. Rimm, and H. M. Kluger, \" High HSP90 expression is associated with decreased survival in breast cancer ,\" Cancer research, vol. 67, pp. 2932-2937, 2007.", + "D. Acosta-Alvear, Y. Zhou, A. Blais, M. Tsikitis, N. H. Lents, C. Arias, C. J. Lennon, Y. Kluger, and B. D. Dynlacht, \" XBP1 controls diverse cell type-and condition-specific transcriptional regulatory networks ,\" Molecular cell, vol. 27, pp. 53-66, 2007.", + "D. P. Tuck, H. M. Kluger, and Y. Kluger, \" Characterizing disease states from topological properties of transcriptional regulatory networks ,\" BMC bioinformatics, vol. 7, pp. 1-19, 2006.", + "Y. Kluger, H. Kluger, and D. Tuck, \" Association between pathways in regulatory networks ,\" in 2006 International Conference of the IEEE Engineering in Medicine and Biology Society, 2006, pp. 2036-2040.", + "H. Kim, W. Hu, and Y. Kluger, \" Unraveling condition specific gene transcriptional regulatory networks in Saccharomyces cerevisiae ,\" BMC bioinformatics, vol. 7, pp. 1-17, 2006.", + "Z.-j. Ye, Y. Kluger, Z. Lian, and S. M. Weissman, \" Two types of precursor cells in a multipotential hematopoietic cell line ,\" Proceedings of the National Academy of Sciences, vol. 102, pp. 18461-18466, 2005.", + "H. M. Kluger, D. C. Lev, Y. Kluger, M. M. McCarthy, G. Kiriakova, R. L. Camp, D. L. Rimm, and J. E. Price, \" Using a xenograft model of human breast cancer metastasis to find genes associated with clinically aggressive disease ,\" Cancer research, vol. 65, pp. 5578-5587, 2005.", + "A. Blais, M. Tsikitis, D. Acosta-Alvear, R. Sharan, Y. Kluger, and B. D. Dynlacht, \" An initial blueprint for myogenic differentiation ,\" Genes & development, vol. 19, pp. 553-569, 2005.", + "X. Zhang, Y. Kluger, Y. Nakayama, R. Poddar, C. Whitney, A. DeTora, S. M. Weissman, and P. E. Newburger, \" Gene expression in mature neutrophils: early responses to inflammatory stimuli ,\" Journal of leukocyte biology, vol. 75, pp. 358-372, 2004.", + "Y. Kluger, D. P. Tuck, J. T. Chang, Y. Nakayama, R. Poddar, N. Kohya, Z. Lian, A. Ben Nasr, H. R. Halaban, D. S. Krause, X. Zhang, P. E. Newburger, and S. M. Weissman, \" Lineage specificity of gene expression patterns ,\" Proc Natl Acad Sci U S A, vol. 101, pp. 6508-13, Apr 27 2004.", + "Y. Kluger, Z. Lian, X. Zhang, P. E. Newburger, and S. M. Weissman, \" A panorama of lineage-specific transcription in hematopoiesis ,\" Bioessays, vol. 26, pp. 1276-1287, 2004.", + "H. M. Kluger, Y. Kluger, M. Gilmore-Hebert, K. DiVito, J. T. Chang, S. Rodov, O. Mironenko, B. M. Kacinski, A. S. Perkins, and E. Sapi, \" cDNA microarray analysis of invasive and tumorigenic phenotypes in a breast cancer model ,\" Laboratory investigation, vol. 84, pp. 320-331, 2004.", + "H. Cam, E. Balciunaite, A. Blais, A. Spektor, R. C. Scarpulla, R. Young, Y. Kluger, and B. D. Dynlacht, \" A common set of gene regulatory networks links metabolism and growth inhibition ,\" Molecular cell, vol. 16, pp. 399-411, 2004.", + "Y. Tsukahara, Z. Lian, X. Zhang, C. Whitney, Y. Kluger, D. Tuck, S. Yamaga, Y. Nakayama, S. M. Weissman, and P. E. Newburger, \" Gene expression in human neutrophils during activation and priming by bacterial lipopolysaccharide ,\" Journal of cellular biochemistry, vol. 89, pp. 848-861, 2003.", + "J. Qian, Y. Kluger, H. Yu, and M. Gerstein, \" Identification and correction of spurious spatial correlations in microarray data ,\" Biotechniques, vol. 35, pp. 42-48, 2003.", + "Y. Kluger, H. Yu, J. Qian, and M. Gerstein, \" Relationship between gene co-expression and probe localization on microarray slides ,\" Bmc Genomics, vol. 4, pp. 1-6, 2003.", + "Y. Kluger, R. Basri, J. T. Chang, and M. Gerstein, \" Spectral biclustering of microarray data: coclustering genes and conditions ,\" Genome research, vol. 13, pp. 703-716, 2003.", + "R. Jansen, H. Yu, D. Greenbaum, Y. Kluger, N. J. Krogan, S. Chung, A. Emili, M. Snyder, J. F. Greenblatt, and M. Gerstein, \" A Bayesian networks approach for predicting protein-protein interactions from genomic data ,\" science, vol. 302, pp. 449-453, 2003.", + "Z. Lian, Y. Kluger, D. S. Greenbaum, D. Tuck, M. Gerstein, N. Berliner, S. M. Weissman, and P. E. Newburger, \" Genomic and proteomic analysis of the myeloid differentiation program: global analysis of gene expression during induced differentiation in the MPRO cell line ,\" Blood, The Journal of the American Society of Hematology, vol. 100, pp. 3209-3220, 2002.", + "Y. V. Subrahmanyam, S. Yamaga, Y. Prashar, H. H. Lee, N. P. Hoe, Y. Kluger, M. Gerstein, J. D. Goguen, P. E. Newburger, and S. M. Weissman, \" RNA expression patterns change dramatically in human neutrophils exposed to bacteria ,\" Blood, The Journal of the American Society of Hematology, vol. 97, pp. 2457-2468, 2001.", + "Z. Lian, L. Wang, S. Yamaga, W. Bonds, Y. Beazer-Barclay, Y. Kluger, M. Gerstein, P. E. Newburger, N. Berliner, and S. M. Weissman, \" Genomic and proteomic analysis of the myeloid differentiation program ,\" Blood, vol. 98, pp. 513-524, 2001.", + "P. Bertone, Y. Kluger, N. Lan, D. Zheng, D. Christendat, A. Yee, A. M. Edwards, C. H. Arrowsmith, G. T. Montelione, and M. Gerstein, \" SPINE: an integrated tracking database and data mining approach for identifying feasible targets in high-throughput structural proteomics ,\" Nucleic acids research, vol. 29, pp. 2884-2898, 2001.", + "D. Christendat, A. Yee, A. Dharamsi, Y. Kluger, A. Savchenko, J. R. Cort, V. Booth, C. D. Mackereth, V. Saridakis, I. Ekiel, G. Kozlov, K. L. Maxwell, N. Wu, L. P. McIntosh, K. Gehring, M. A. Kennedy, A. R. Davidson, E. F. Pai, M. Gerstein, A. M. Edwards, and C. H. Arrowsmith, \" Structural proteomics of an archaeon ,\" Nat Struct Biol, vol. 7, pp. 903-9, Oct 2000.", + "D. Christendat, A. Yee, A. Dharamsi, Y. Kluger, M. Gerstein, C. H. Arrowsmith, and A. M. Edwards, \" Structural proteomics: prospects for high throughput sample preparation ,\" Progress in biophysics and molecular biology, vol. 73, pp. 339-345, 2000.", + "V. Koch, J. Randrup, X.-N. Wang, and Y. Kluger, \" Dileptons from disoriented chiral condensates ,\" Nuclear Physics A, vol. 638, pp. 447c-450c, 1998.", + "Y. Kluger, E. Mottola, and J. M. Eisenberg, \" Quantum Vlasov equation and its Markov limit ,\" Physical Review D, vol. 58, Dec 15 1998.", + "Y. Kluger, V. Koch, J. Randrup, and X.-N. Wang, \" Dileptons from disoriented chiral condensates ,\" Physical Review C, vol. 57, p. 280, 1998.", + "F. Cooper, S. Habib, Y. Kluger, and E. Mottola, \" Nonequilibrium dynamics of symmetry breaking in ? F 4 theory ,\" Physical Review D, vol. 55, p. 6471, 1997.", + "S. Habib, Y. Kluger, E. Mottola, and J. P. Paz, \" Dissipation and decoherence in mean field theory ,\" Physical review letters, vol. 76, p. 4660, 1996.", + "F. Cooper, Y. Kluger, and E. Mottola, \" Anomalous transverse distribution of pions as a signal for the production of disoriented chiral condensates ,\" Physical Review C, vol. 54, p. 3298, 1996.", + "Y. Kluger, F. Cooper, E. Mottola, J. Paz, and A. Kovner, \" Quantum evolution of the disoriented chiral condensates ,\" Nuclear Physics A, vol. 590, pp. 581-584, 1995.", + "F. Cooper, Y. Kluger, E. Mottola, and J. P. Paz, \" Quantum evolution of disoriented chiral condensates ,\" Physical Review D, vol. 51, p. 2377, 1995.", + "F. Cooper, J. Dawson, S. Habib, Y. Kluger, D. Meredith, and H. Shepard, \" Semiquantum chaos and the large N expansion ,\" Physica D: Nonlinear Phenomena, vol. 83, pp. 74-97, 1995.", + "Y. Kluger, \" Back-reaction beyond the mean field approximation ,\" in Hot and Dense Nuclear Matter, ed: Springer, 1994, pp. 635-646.", + "F. Cooper, S. Habib, Y. Kluger, E. Mottola, J. P. Paz, and P. R. Anderson, \" Nonequilibrium quantum fields in the large-N expansion ,\" Physical Review D, vol. 50, p. 2848, 1994.", + "G. Berman, E. Bulgakov, D. Holm, and Y. Kluger, \" Dynamical chaos in SU (2)? U (1) theory ,\" Physics Letters A, vol. 194, pp. 251-264, 1994.", + "Y. Kluger, J. Eisenberg, and B. Svetitsky, \" Pair production in a strong electric field: an initial value problem in quantum field theory ,\" International Journal of Modern Physics E, vol. 2, pp. 333-380, 1993.", + "F. Cooper, J. Eisenberg, Y. Kluger, E. Mottola, and B. Svetitsky, \" Particle production in the central rapidity region ,\" Physical Review D, vol. 48, p. 190, 1993.", + "Y. Kluger, J. Eisenberg, B. Svetitsky, F. Cooper, and E. Mottola, \" Fermion pair production in a strong electric field ,\" Physical Review D, vol. 45, p. 4659, 1992.", + "Y. Kluger, J. Eisenberg, B. Svetitsky, F. Cooper, and E. Mottola, \" Pair production in a strong electric field ,\" Physical Review Letters, vol. 67, p. 2427, 1991.", + "Transport equations for the quark–gluon plasma , J.M. Eisenberg, Y. Kluger and A. Rosenhauer, in The Nuclear Equation of State, W. Greiner, ed. (Plenum, New York, 1989) p. 501.", + "Y. Kluger and J. M. Eisenberg, \" THE ISOSCALAR CHARGE FORM FACTOR IN NUCLEI OF A=2, 3 OBTAINED IN THE SKYRME MODEL ,\" International Journal of Modern Physics A, vol. 03, pp. 2127-2142, 1988/09/01 1988.", + "300 George Street New Haven, CT 06511-6663", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Knauert Lab", + "lab_url": "https://medicine.yale.edu/lab/knauert/", + "research_bio": "INFORMATION FOR Our lab investigates sleep deprivation and circadian disruption in critically ill patients. Sleep deprivation and circadian disruption are likely key factors in the development of ICU delirium. Furthermore, sleep and circadian abnormalities are implicated in broader perturbations of normal physiology including abnormalities of cardiovascular, immune, endocrine and metabolic systems. Over the long-term, this patient-oriented research will improve outcomes in the ICU by investigating questions and developing interventions at the intersection of sleep, circadian biology, and critical illness. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Koff Lab", + "lab_url": "https://medicine.yale.edu/lab/koff/", + "research_bio": "INFORMATION FOR Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/koff/pubs/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Pulmonary, Critical Care & Sleep Medicine /", + "Research", + "Publications", + "Members", + "Contact Us", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Publications", + "Members", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Corrigendum to \"Particle size distribution of viable nebulized bacteriophage for the treatment of multi-drug resistant Pseudomonas aeruginosa\" [Respiratory Medicine and Research 86 (2024) 101133]. Thompson DL, Semersky Z, Feinn R, Huang P, Turner PE, Chan BK, Koff JL, Murray TS. Respir Med Res. 2025 Oct 8; 2025 Oct 8. PMID: 41067035.", + "A ventilated perfused lung model platform to dissect the response of the lungs to viral infection. Derman ID, Alioglu MA, Moses JC, Chroneos ZC, Yilmaz YO, Banerjee D, Koff J, Rizvi SHA, Klunk DN, Celik N, Pochareddy S, Umstead TM, Namli I, Holton SE, Mikacenic C, Thompson JL, Castaneda DC, Hickey DR, Nagamine M, Warang P, Schotsaert M, Chen P, Peeples ME, Palucka K, Ozbolat IT. Trends Biotechnol. 2025 Jul; 2025 Apr 24. PMID: 40280814.", + "Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxic Acute Lung Injury. Harris ZM, Korde A, Khoury J, Manning EP, Stanley G, Mitchell K, Sun Y, Hu B, Shin HJ, Joerns J, Clark B, Placek L, Unutmaz D, Moldobaeva A, Sharma L, Sauler M, Rajagopalan G, Zhang X, Wang H, Ghaedi M, Kang MJ, Koff JL. bioRxiv. 2025 May 23; 2025 May 23. PMID: 40475627.", + "Personalized inhaled bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis. Chan BK, Stanley GL, Kortright KE, Vill AC, Modak M, Ott IM, Sun Y, Würstle S, Grun CN, Kazmierczak BI, Rajagopalan G, Harris ZM, Britto CJ, Stewart J, Talwalkar JS, Appell CR, Chaudary N, Jagpal SK, Jain R, Kanu A, Quon BS, Reynolds JM, Teneback CC, Mai QA, Shabanova V, Turner PE, Koff JL. Nat Med. 2025 May; 2025 Apr 29. PMID: 40301561.", + "Changing Epidemiology of Pediatric Pulmonary Exacerbations in Cystic Fibrosis. Fireizen Y, Ahmed M, Vigers T, Akong K, Ryu J, Hahn A, Fanous H, Koumbourlis A, Tirakitsoontorn P, Arrieta A, Burgener EB, Koff J, Cogen JD, Bouzek DC, Hanley E, Keck A, Stout D, Bradley J, Sagel SD. Pediatr Pulmonol. 2025 Mar. PMID: 40018992.", + "Particle size distribution of viable nebulized bacteriophage for the treatment of multi-drug resistant Pseudomonas aeruginosa. Thompson DL, Semersky Z, Feinn R, Huang P, Turner PE, Chan BK, Koff JL, Murray TS. Respir Med Res. 2024 Nov; 2024 Jul 25. PMID: 39121591.", + "Phage Therapy for Respiratory Infections: Opportunities and Challenges. Khosravi A, Chen Q, Echterhof A, Koff JL, Bollyky PL. Lung. 2024 Jun; 2024 May 21. PMID: 38772946.", + "Lytic bacteriophages induce the secretion of antiviral and proinflammatory cytokines from human respiratory epithelial cells. Zamora PF, Reidy TG, Armbruster CR, Sun M, Van Tyne D, Turner PE, Koff JL, Bomberger JM. PLoS Biol. 2024 Apr; 2024 Apr 23. PMID: 38652717.", + "Evaluation of a Virtual Reality-Based Open Educational Resource Software. Würstle S, Spanke LM, Mehlhase N, Stanley G, Koff J, Dimitriadis S, König S, Hann A. J Med Educ Curric Dev. 2024 Jan-Dec; 2024 Apr 2. PMID: 38572090.", + "Human iPSC-Based Model of COPD to Investigate Disease Mechanisms, Predict SARS-COV-2 Outcome, and Test Preventive Immunotherapy. Dagher R, Moldobaeva A, Gubbins E, Clark S, Madel Alfajaro M, Wilen CB, Hawkins F, Qu X, Chien Chiang C, Li Y, Clarke L, Ikeda Y, Brown C, Kolbeck R, Ma Q, Rojas M, Koff JL, Ghaedi M. Stem Cells. 2024 Mar 14. PMID: 38183264.", + "Novel Approaches to Multidrug-Resistant Infections in Cystic Fibrosis. Murray TS, Stanley G, Koff JL. Infect Dis Clin North Am. 2024 Mar. PMID: 38280761.", + "Lytic bacteriophages interact with respiratory epithelial cells and induce the secretion of antiviral and proinflammatory cytokines. Zamora PF, Reidy TG, Armbruster CR, Sun M, Van Tyne D, Turner PE, Koff JL, Bomberger JM. bioRxiv. 2024 Feb 6; 2024 Feb 6. PMID: 38370761.", + "Optimized preparation pipeline for emergency phage therapy against Pseudomonas aeruginosa at Yale University. Würstle S, Lee A, Kortright KE, Winzig F, An W, Stanley GL, Rajagopalan G, Harris Z, Sun Y, Hu B, Blazanin M, Hajfathalian M, Bollyky PL, Turner PE, Koff JL, Chan BK. Sci Rep. 2024 Feb 1; 2024 Feb 1. PMID: 38302552.", + "Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia. Castaneda DC, Jangra S, Yurieva M, Martinek J, Callender M, Coxe M, Choi A, García-Bernalt Diego J, Lin J, Wu TC, Marches F, Chaussabel D, Yu P, Salner A, Aucello G, Koff J, Hudson B, Church SE, Gorman K, Anguiano E, García-Sastre A, Williams A, Schotsaert M, Palucka K. iScience. 2023 Aug 18; 2023 Jul 13. PMID: 37520727.", + "A Novel Zinc (II) Porphyrin Is Synergistic with PEV2 Bacteriophage against Pseudomonas aeruginosa Infections. Geyer J, Krupa KA, Harris ZM, Sun Y, Sharma L, Würstle S, Hu B, Stanley G, Rajagopalan G, Pellot E, Koff JL, Robinson JB. Antibiotics (Basel). 2023 Apr 10; 2023 Apr 10. PMID: 37107097.", + "Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia. Castaneda DC, Jangra S, Yurieva M, Martinek J, Callender M, Coxe M, Choi A, Diego JG, Lin J, Wu TC, Marches F, Chaussabel D, Yu P, Salner A, Aucello G, Koff J, Hudson B, Church SE, Gorman K, Anguiano E, García-Sastre A, Williams A, Schotsaert M, Palucka K. bioRxiv. 2023 Mar 31; 2023 Mar 31. PMID: 37034597.", + "COVID-19 bacteremic co-infection is a major risk factor for mortality, ICU admission, and mechanical ventilation. Patton MJ, Orihuela CJ, Harrod KS, Bhuiyan MAN, Dominic P, Kevil CG, Fort D, Liu VX, Farhat M, Koff JL, Lal CV, Gaggar A, Richter RP, Erdmann N, Might M, Gaggar A. Crit Care. 2023 Jan 23; 2023 Jan 23. PMID: 36691080.", + "Bacteriophage Therapy for Pan-Drug-Resistant Pseudomonas aeruginosa in Two Persons With Cystic Fibrosis. Hahn A, Sami I, Chaney H, Koumbourlis AC, Del Valle Mojica C, Cochrane C, Chan BK, Koff JL. J Investig Med High Impact Case Rep. 2023 Jan-Dec. PMID: 37515541.", + "IFN-γ Is Protective in Cytokine Release Syndrome-associated Extrapulmonary Acute Lung Injury. Sun Y, Hu B, Stanley G, Harris ZM, Gautam S, Homer R, Koff JL, Rajagopalan G. Am J Respir Cell Mol Biol. 2023 Jan. PMID: 36125351.", + "Inhaled Bacteriophage Therapy for Multi-Drug Resistant Achromobacter. Winzig F, Gandhi S, Lee A, Würstle S, Stanley GL, Capuano I, Neuringer I, Koff JL, Turner PE, Chan BK. Yale J Biol Med. 2022 Dec; 2022 Dec 22. PMID: 36568830.", + "Novel Approaches to Multidrug-Resistant Infections in Cystic Fibrosis. Murray TS, Stanley G, Koff JL. Clin Chest Med. 2022 Dec. PMID: 36344073.", + "Epidermal Growth Factor Receptor Inhibition Is Protective in Hyperoxia-Induced Lung Injury. Harris ZM, Sun Y, Joerns J, Clark B, Hu B, Korde A, Sharma L, Shin HJ, Manning EP, Placek L, Unutmaz D, Stanley G, Chun H, Sauler M, Rajagopalan G, Zhang X, Kang MJ, Koff JL. Oxid Med Cell Longev. 2022; 2022 Sep 20. PMID: 36193076.", + "I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations. Files DC, Matthay MA, Calfee CS, Aggarwal NR, Asare AL, Beitler JR, Berger PA, Burnham EL, Cimino G, Coleman MH, Crippa A, Discacciati A, Gandotra S, Gibbs KW, Henderson PT, Ittner CAG, Jauregui A, Khan KT, Koff JL, Lang J, LaRose M, Levitt J, Lu R, McKeehan JD, Meyer NJ, Russell DW, Thomas KW, Eklund M, Esserman LJ, Liu KD. BMJ Open. 2022 Jun 6; 2022 Jun 6. PMID: 35667714.", + "Bronchial epithelium epithelial-mesenchymal plasticity forms aberrant basaloid-like cells in vitro. Uthaya Kumar DB, Motakis E, Yurieva M, Kohar V, Martinek J, Wu TC, Khoury J, Grassmann J, Lu M, Palucka K, Kaminski N, Koff JL, Williams A. Am J Physiol Lung Cell Mol Physiol. 2022 Jun 1; 2022 Apr 19. PMID: 35438006.", + "A neutrophil activation signature predicts critical illness and mortality in COVID-19. Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun HJ. Blood Adv. 2021 Mar 9. PMID: 33635335.", + "A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY: Learning From the Past, Looking to the Future. Lutchmansingh DD, Knauert MP, Antin-Ozerkis DE, Chupp G, Cohn L, Dela Cruz CS, Ferrante LE, Herzog EL, Koff J, Rochester CL, Ryu C, Singh I, Tickoo M, Winks V, Gulati M, Possick JD. Chest. 2021 Mar; 2020 Nov 4. PMID: 33159907.", + "Multi-dimensional clinical phenotyping of a national cohort of adult cystic fibrosis patients. Conrad DJ, Billings J, Teneback C, Koff J, Rosenbluth D, Bailey BA, Jain R. J Cyst Fibros. 2021 Jan; 2020 Sep 15. PMID: 32948498.", + "A neutrophil activation signature predicts critical illness and mortality in COVID-19. Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun H. medRxiv. 2020 Sep 2; 2020 Sep 2. PMID: 32908988.", + "Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Lancet Haematol. 2020 Aug; 2020 Jun 30. PMID: 32619411.", + "\"Small\" Intestinal Immunopathology Plays a \"Big\" Role in Lethal Cytokine Release Syndrome, and Its Modulation by Interferon-γ, IL-17A, and a Janus Kinase Inhibitor. Kale SD, Mehrkens BN, Stegman MM, Kastelberg B, Carnes H, McNeill RJ, Rizzo A, Karyala SV, Coutermarsh-Ott S, Fretz JA, Sun Y, Koff JL, Rajagopalan G. Front Immunol. 2020; 2020 Jun 26. PMID: 32676080.", + "Metabolic Adaptation in Methicillin-Resistant Staphylococcus aureus Pneumonia. Gabryszewski SJ, Wong Fok Lung T, Annavajhala MK, Tomlinson KL, Riquelme SA, Khan IN, Noguera LP, Wickersham M, Zhao A, Mulenos AM, Peaper D, Koff JL, Uhlemann AC, Prince A. Am J Respir Cell Mol Biol. 2019 Aug. PMID: 30742488.", + "Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria. Kortright KE, Chan BK, Koff JL, Turner PE. Cell Host Microbe. 2019 Feb 13. PMID: 30763536.", + "Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages. Di Pietro C, Zhang PX, O'Rourke TK, Murray TS, Wang L, Britto CJ, Koff JL, Krause DS, Egan ME, Bruscia EM. Sci Rep. 2017 Sep 7; 2017 Sep 7. PMID: 28883468.", + "Correction: DNA Repair Interacts with Autophagy To Regulate Inflammatory Responses to Pulmonary Hyperoxia. Ye Y, Lin P, Zhang W, Tan S, Zhou X, Li R, Pu Q, Koff JL, Dhasarathy A, Ma F, Deng X, Jiang J, Wu M. J Immunol. 2017 Aug 1. PMID: 28739596.", + "Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice. Wong CK, Smith CA, Sakamoto K, Kaminski N, Koff JL, Goldstein DR. J Immunol. 2017 Aug 1; 2017 Jun 23. PMID: 28646038.", + "Response to Comment on \"DNA Repair Interacts with Autophagy To Regulate Inflammatory Responses to Pulmonary Hyperoxia\". Ye Y, Lin P, Zhang W, Tan S, Zhou X, Li R, Pu Q, Koff JL, Dhasarathy A, Ma F, Deng X, Jiang J, Wu M. J Immunol. 2017 Jul 15. PMID: 28696327.", + "Cystic Fibrosis Transmembrane Regulator Modulators: Implications for the Management of Depression and Anxiety in Cystic Fibrosis. Talwalkar JS, Koff JL, Lee HB, Britto CJ, Mulenos AM, Georgiopoulos AM. Psychosomatics. 2017 Jul-Aug; 2017 Apr 5. PMID: 28576305.", + "DNA Repair Interacts with Autophagy To Regulate Inflammatory Responses to Pulmonary Hyperoxia. Ye Y, Lin P, Zhang W, Tan S, Zhou X, Li R, Pu Q, Koff JL, Dhasarathy A, Ma F, Deng X, Jiang J, Wu M. J Immunol. 2017 Apr 1; 2017 Feb 15. PMID: 28202616.", + "Cystic Fibrosis. Koff JL. Clin Chest Med. 2016 Mar; 2015 Dec 24. PMID: 26857777.", + "Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation. Zhang PX, Cheng J, Zou S, D'Souza AD, Koff JL, Lu J, Lee PJ, Krause DS, Egan ME, Bruscia EM. Nat Commun. 2015 Feb 10; 2015 Feb 10. PMID: 25665524.", + "EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production. Kalinowski A, Ueki I, Min-Oo G, Ballon-Landa E, Knoff D, Galen B, Lanier LL, Nadel JA, Koff JL. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 15; 2014 May 16. PMID: 24838750.", + "Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium. Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel JA, Koff JL. J Exp Med. 2013 Sep 23; 2013 Sep 2. PMID: 23999497.", + "Rhinovirus and other respiratory viruses exert different effects on lung allograft function that are not mediated through acute rejection. Sayah DM, Koff JL, Leard LE, Hays SR, Golden JA, Singer JP. Clin Transplant. 2013 Jan-Feb; 2012 Dec 30. PMID: 23278569.", + "Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary fibrosis. Zhou Y, Lee JY, Lee CM, Cho WK, Kang MJ, Koff JL, Yoon PO, Chae J, Park HO, Elias JA, Lee CG. J Biol Chem. 2012 Dec 7; 2012 Oct 19. PMID: 23086930.", + "Airway microbiota and pathogen abundance in age-stratified cystic fibrosis patients. Cox MJ, Allgaier M, Taylor B, Baek MS, Huang YJ, Daly RA, Karaoz U, Andersen GL, Brown R, Fujimura KE, Wu B, Tran D, Koff J, Kleinhenz ME, Nielson D, Brodie EL, Lynch SV. PLoS One. 2010 Jun 23; 2010 Jun 23. PMID: 20585638.", + "Neutrophil-derived IL-6 limits alveolar barrier disruption in experimental ventilator-induced lung injury. Wolters PJ, Wray C, Sutherland RE, Kim SS, Koff J, Mao Y, Frank JA. J Immunol. 2009 Jun 15. PMID: 19494331.", + "Treatment of recurrent Crohn's uveitis with infliximab. Ally MR, Veerappan GR, Koff JM. Am J Gastroenterol. 2008 Aug. PMID: 18796120.", + "Hemodialysis for hyperammonemia associated with ornithine transcarbamylase deficiency. Collen JF, Das NP, Koff JM, Neff RT, Abbott KC. Appl Clin Genet. 2008; 2008 Jul 24. PMID: 23776342.", + "Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium. Koff JL, Shao MX, Ueki IF, Nadel JA. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 2008 Mar 28. PMID: 18375743.", + "False positive acetaminophen concentrations in patients with liver injury. Polson J, Wians FH Jr, Orsulak P, Fuller D, Murray NG, Koff JM, Khan AI, Balko JA, Hynan LS, Lee WM. Clin Chim Acta. 2008 May; 2008 Jan 26. PMID: 18279672.", + "Regulation of interleukin-8 via an airway epithelial signaling cascade. Nakanaga T, Nadel JA, Ueki IF, Koff JL, Shao MX. Am J Physiol Lung Cell Mol Physiol. 2007 May; 2007 Jan 12. PMID: 17220369.", + "The cost-effectiveness of CT colonography in screening for colorectal neoplasia. Vijan S, Hwang I, Inadomi J, Wong RK, Choi JR, Napierkowski J, Koff JM, Pickhardt PJ. Am J Gastroenterol. 2007 Feb; 2006 Dec 11. PMID: 17156139.", + "Pseudomonas lipopolysaccharide accelerates wound repair via activation of a novel epithelial cell signaling cascade. Koff JL, Shao MX, Kim S, Ueki IF, Nadel JA. J Immunol. 2006 Dec 15. PMID: 17142770.", + "Case report: a case of wood-smoke-related pulmonary disease. Diaz JV, Koff J, Gotway MB, Nishimura S, Balmes JR. Environ Health Perspect. 2006 May. PMID: 16675433.", + "Inverted appendiceal orifice masquerading as a cecal polyp on virtual colonoscopy. Koff JM, Choi JR, Hwang I. Gastrointest Endosc. 2005 Aug. PMID: 16047004.", + "Maintenance immunosuppression use and the associated risk of avascular necrosis after kidney transplantation in the United States. Abbott KC, Koff J, Bohen EM, Oglesby RJ, Agodoa LY, Lentine KL, Schnitzler MA. Transplantation. 2005 Feb 15. PMID: 15699764.", + "Retained endoclip. Koff JM, Napierkowski JJ, Smith MT. Gastrointest Endosc. 2005 Feb. PMID: 15729242.", + "Impact of diabetes and hepatitis after kidney transplantation on patients who are affected by hepatitis C virus. Abbott KC, Lentine KL, Bucci JR, Agodoa LY, Koff JM, Holtzmuller KC, Schnitzler MA. J Am Soc Nephrol. 2004 Dec. PMID: 15579520.", + "Echolalia in a liver transplant recipient. Koff JM, Matsumoto CS, Holtzmuller KC. Transplantation. 2004 Aug 15. PMID: 15316384.", + "Hepatitis C with normal liver enzymes: to treat or not to treat. Pro: most patients should be treated. Koff JM, Younossi Z. Am J Gastroenterol. 2004 Jun. PMID: 15180709.", + "Obtaining antibiotics without a prescription. Goff BJ, Koff JM, Geiling JA. N Engl J Med. 2002 Jul 18. PMID: 12124419.", + "The Anlyan Center for Medical Research & Education 300 Cedar Street New Haven, CT 06510", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Krause Lab", + "lab_url": "https://medicine.yale.edu/lab/krause/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/krause/publications", + "publications": null + }, + { + "lab_name": "Kriegel Lab", + "lab_url": "https://medicine.yale.edu/lab/kriegel/", + "research_bio": "INFORMATION FOR Copy Link The gut microbiota, the collection of trillions of commensals colonizing the gastrointestinal tract, does not elicit a pathologic immune response in healthy hosts even though immune cells are constantly in contact with microbial antigens at the mucosal surfaces. This phenomenon is partly due to the fact thatthe human microbiota and immune system have co-evolved for millennia with the host. Diet and environmental influences that have shaped these processes in the past are very different in today's societies. Recent changes in the gut microbial community composition are thought to contribute to metabolic and immune-mediated diseases. An emerging theme in autoimmunity research is that outgrowth of detrimental commensals (\"pathobionts\") or loss of beneficial commensals (\"symbionts\") unleashes the autoimmune process in a genetically susceptible host by various mechanisms. While evidence exists for this paradigm in some mouse models, the proof in human autoimmune diseases is still outstanding. Major aims of this laboratory are to define the microbial community composition ofgastrointestinal, cutaneous and oral microbiomesin autoimmune diseases, to study host-microbiota interactions in vitro and vivo, and to potentially prove causal relationships using humanized gnotobiotic animals. The ultimate goal is to develop novel biomarkers and therapeutic strategies for human autoimmune diseases. Copy Link The study“Translocation of a gut pathobiont drives autoimmunity in mice and humans”by Manfredo Vieira et al. published on March 9, 2018, inSciencecan be accessed without a paywall via our website using the following links: A 3-minutevideosummarizing this work can be foundpublished here on YouTube. Click here to read the accompanyingYaleNewsarticle. Our study in collaboration with the Wolin laboratory entitled“Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus”by Greiling et al. published on March 28, 2018, inScience Translational Medicineis accessible by clicking here to visit the Science Magzine website. A 2-minutevideosummarizing this work can be foundpublished here on YouTube. Click here to read the accompanyingYaleNewsarticle. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Krishnakumar Lab", + "lab_url": "https://medicine.yale.edu/lab/krishnakumar/", + "research_bio": "INFORMATION FOR Copy Link Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/krishnakumar/publications", + "publications": null + }, + { + "lab_name": "Kyriakides Lab", + "lab_url": "https://medicine.yale.edu/lab/kyriakides/", + "research_bio": "INFORMATION FOR The main area of my research is the elucidation of the molecular events that dictate the course of healing and especially inflammation and angiogenesis following the implantation of biomaterials and scaffolds for tissue engineering applications. Our primary research focus is on three molecules, MCP-1, MMP-9, and thrombospondin (TSP)-2 that we have shown to be critical to various aspects of these processes. In addition, through the process of molecular dissection of cell-matrix interactions, we aim to incorporate rational design in the development of bioengineering applications such as tissue-engineered vascular grafts. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/kyriakides/publications/", + "publications": [ + "Yale School of Medicine /", + "Pathology /", + "Research Role of TSP-2 Molecular Events in the Foreign Body Response", + "Role of TSP-2", + "Molecular Events in the Foreign Body Response", + "News", + "People", + "Publications", + "Contact Us", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "Contact Us", + "News", + "", + "", + "", + "", + "", + "", + "10 Amistad Street PO Box 208089 New Haven, CT 06509-8089", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Laboratory for Healthy Minds", + "lab_url": "https://medicine.yale.edu/lab/lhm/", + "research_bio": "INFORMATION FOR The Yale LHM lab conducts translational research on stress and addiction using multimodal methods such as fMRI, ECG and HPA axis measures. This multimodal approach provides valuable, neurobiological information on the dynamic interactions between the central nervous system and its periphery. LHM lab also develops technology-assisted assessments and intervention programs to aid and improve health practice and outcome. Copy Link Using functional magnetic resonance imaging (fMRI), we examine brain activity and connectivity patterns to understand the neural mechanisms and to predict specific risk factors associated with stress and addiction. Copy Link We examine heart rate (HR) and heart rate variability (HRV) using electrocardiogram (ECG), often concurrently with fMRI. HR spontaneously fluctuates, even during resting conditions. HRV is the time interval between heartbeats and allows detection of these fluctuations in specific frequencies. HR and HRV provides insight into autonomic and cardiovascular function. We are interested in HR/HRV’s interactions with brain and behaviors in stress, addiction and coping mechanisms. Copy Link Stress responses trigger HPA axis arousal. Glucocorticoids increases dopamine efflux in the prefrontal cortex (PFC), leading to PFC dysfunction and enhancing the reinforcing effects of substances under dyscontrolled stress states. We examine stress hormone responses (e.g., cortisol, ACTH) to understand HPA axis function and its interactions with brain-behavior relationships. Copy Link LHM develops computerized and smartphone-based assessment and intervention tools to reach out sub-clinical and clinical populations who reside in various community settings. ", + "publications_page": null, + "publications": null + }, + { + "lab_name": "LaMotte Lab", + "lab_url": "https://medicine.yale.edu/lab/lamotte/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/lamotte/publications/", + "publications": [ + "Yale School of Medicine /", + "Anesthesiology /", + "Members", + "Publications", + "Contact Us", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Members", + "Publications", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Tompkins Memorial Pavilion 333 Cedar Street PO Box 208051 New Haven, CT 06520-8051", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Le Zhang Lab", + "lab_url": "https://medicine.yale.edu/lab/le-zhang/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Lee Lab", + "lab_url": "https://medicine.yale.edu/lab/mlee/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Levey Lab", + "lab_url": "https://medicine.yale.edu/lab/leveylab/", + "research_bio": "INFORMATION FOR Welcome to Levey Lab, a hub for groundbreaking research in genome-wide association studies (GWAS). Led by Dr. Daniel F. Levey, our team is at the forefront of unraveling the genetic underpinnings of various complex traits, with a focus on the intersection of anxiety, depression, substance use disorders and personality traits. At Levey Lab, we harness the power of GWAS to identify genetic variants associated with traits such as disease susceptibility, drug repurposing, and complex phenotypes. Through advanced statistical analysis and collaboration with experts across disciplines, we strive to translate genomic discoveries into potential novel biological targets and public health interventions. Our website offers a glimpse into our current projects, methodologies, and publicly shared datasets. Whether you're a fellow researcher, a potential collaborator, or simply curious about the latest advancements in genomics, we invite you to explore and engage with our work. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/leveylab/publications", + "publications": null + }, + { + "lab_name": "Lolis Lab", + "lab_url": "https://medicine.yale.edu/lab/lolis/", + "research_bio": "INFORMATION FOR The focus of the lab is to study proteins involved in inflammation and cancer. X-ray crystallography (or NMR) is used to determine the structure of these proteins or protein complexed to other physiological molecules or small molecule inhibitors. Structural biology is complemented by a variety of other techniques to understand the signaling pathway of these molecules or the mechanism that leads to disease. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Lombroso Lab", + "lab_url": "https://medicine.yale.edu/lab/lombroso/", + "research_bio": "INFORMATION FOR The Lombroso Laboratory studies the processes of mammalian learning that are disrupted in various neuropsychiatric disorders. We are involved in translational neuroscience with a focus on Alzheimer's disease, fragile X syndrome, and schizophrenia. Central to this investigation is a brain-specific protein tyrosine phosphatase called STEP and its role in regulating intracellular signaling. Signals that lead to STEP inactivation potentiate learning, whereas signals that lead to STEP activation oppose the development of synaptic plasticity. Reducing STEP levels significantly attenuates behavioral and cognitive deficits in each of these disorders. These studies validate STEP as a target for drug discovery. Therefore, a separate project in the lab is characterizing inhibitors of STEP in cellular and in vivo models. We're a proud part of the Yale Child Study Center. Visit thedepartment websiteto learn more about the rest of our group. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/lombroso/publications/", + "publications": [ + "Yale School of Medicine /", + "Child Study Center /", + "Faculty and Staff", + "Former Lab Members", + "Undergraduate Research", + "Contact", + "Research Alzheimer's Disease Fragile X Syndrome Schizophrenia In the News", + "Alzheimer's Disease", + "Fragile X Syndrome", + "Schizophrenia", + "In the News", + "Publications Development and Neurobiology Columns", + "Development and Neurobiology Columns", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Home", + "Publications", + "Development and Neurobiology Columns", + "", + "", + "", + "", + "", + "", + "Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain. Dedek A, Xu J, Lorenzo LÉ, Godin AG, Kandegedara CM, Glavina G, Landrigan JA, Lombroso PJ, De Koninck Y, Tsai EC, Hildebrand ME. Brain. 2022 Apr 29. PMID: 35323848.", + "Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP). Lambert LJ, Grotegut S, Celeridad M, Gosalia P, Backer LJ, Bobkov AA, Salaniwal S, Chung TD, Zeng FY, Pass I, Lombroso PJ, Cosford ND, Tautz L. Int J Mol Sci. 2021 Apr 23; 2021 Apr 23. PMID: 33922601.", + "STEP inhibition prevents Aβ-mediated damage in dendritic complexity and spine density in Alzheimer's disease. Chatterjee M, Kwon J, Benedict J, Kamceva M, Kurup P, Lombroso PJ. Exp Brain Res. 2021 Mar; 2021 Jan 9. PMID: 33420799.", + "Inhibition of striatal-enriched protein tyrosine phosphatase (STEP) activity reverses behavioral deficits in a rodent model of autism. Chatterjee M, Singh P, Xu J, Lombroso PJ, Kurup PK. Behav Brain Res. 2020 Aug 5; 2020 May 24. PMID: 32461127.", + "The activity of the Striatal-enriched protein tyrosine phosphatase in neuronal cells is modulated by adenosine A(2A) receptor. Mallozzi C, Pepponi R, Visentin S, Chiodi V, Lombroso PJ, Bader M, Popoli P, Domenici MR. J Neurochem. 2020 Feb; 2019 Oct 10. PMID: 31520531.", + "Altered Intracellular Calcium Homeostasis Underlying Enhanced Glutamatergic Transmission in Striatal-Enriched Tyrosine Phosphatase (STEP) Knockout Mice. Bosco F, Valente P, Milanese M, Piccini A, Messa M, Bonanno G, Lombroso P, Baldelli P, Benfenati F, Giovedì S. Mol Neurobiol. 2018 Oct; 2018 Mar 5. PMID: 29508281.", + "The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline. Castonguay D, Dufort-Gervais J, Ménard C, Chatterjee M, Quirion R, Bontempi B, Schneider JS, Arnsten AFT, Nairn AC, Norris CM, Ferland G, Bézard E, Gaudreau P, Lombroso PJ, Brouillette J. Curr Biol. 2018 Apr 2; 2018 Mar 22. PMID: 29576474.", + "Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP(61). Xu J, Kurup P, Nairn AC, Lombroso PJ. Mol Neurobiol. 2018 Apr; 2017 May 2. PMID: 28466270.", + "STEP inhibition reverses behavioral, electrophysiologic, and synaptic abnormalities in Fmr1 KO mice. Chatterjee M, Kurup PK, Lundbye CJ, Hugger Toft AK, Kwon J, Benedict J, Kamceva M, Banke TG, Lombroso PJ. Neuropharmacology. 2018 Jan; 2017 Sep 21. PMID: 28943283.", + "Intra-prelimbic cortical inhibition of striatal-enriched tyrosine phosphatase suppresses cocaine seeking in rats. Siemsen BM, Lombroso PJ, McGinty JF. Addict Biol. 2018 Jan; 2017 Mar 28. PMID: 28349660.", + "Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases. Tjin CC, Otley KD, Baguley TD, Kurup P, Xu J, Nairn AC, Lombroso PJ, Ellman JA. ACS Cent Sci. 2017 Dec 27; 2017 Dec 6. PMID: 29296673.", + "X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors. Witten MR, Wissler L, Snow M, Geschwindner S, Read JA, Brandon NJ, Nairn AC, Lombroso PJ, Käck H, Ellman JA. J Med Chem. 2017 Nov 22; 2017 Nov 8. PMID: 29116812.", + "Molecular underpinnings of neurodegenerative disorders: striatal-enriched protein tyrosine phosphatase signaling and synaptic plasticity. Lombroso PJ, Ogren M, Kurup P, Nairn AC. F1000Res. 2016; 2016 Dec 29. PMID: 29098072.", + "STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit. Tian M, Xu J, Lei G, Lombroso PJ, Jackson MF, MacDonald JF. Sci Rep. 2016 Nov 18; 2016 Nov 18. PMID: 27857196.", + "BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome. Saavedra A, Puigdellívol M, Tyebji S, Kurup P, Xu J, Ginés S, Alberch J, Lombroso PJ, Pérez-Navarro E. Mol Neurobiol. 2016 Aug; 2015 Jul 30. PMID: 26223799.", + "Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice. Xu J, Kurup P, Baguley TD, Foscue E, Ellman JA, Nairn AC, Lombroso PJ. Cell Mol Life Sci. 2016 Apr; 2015 Oct 8. PMID: 26450419.", + "Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibition. Azkona G, Saavedra A, Aira Z, Aluja D, Xifró X, Baguley T, Alberch J, Ellman JA, Lombroso PJ, Azkue JJ, Pérez-Navarro E. Pain. 2016 Feb. PMID: 26270590.", + "Role of Striatal-Enriched Tyrosine Phosphatase in Neuronal Function. Kamceva M, Benedict J, Nairn AC, Lombroso PJ. Neural Plast. 2016; 2016 Apr 12. PMID: 27190655.", + "Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels. Xu J, Kurup P, Azkona G, Baguley TD, Saavedra A, Nairn AC, Ellman JA, Pérez-Navarro E, Lombroso PJ. J Neurochem. 2016 Jan; 2015 Sep 17. PMID: 26316048.", + "Striatal-enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway. Xu J, Kurup P, Foscue E, Lombroso PJ. J Neurochem. 2015 Aug; 2015 May 25. PMID: 25951993.", + "Striatal-enriched protein tyrosine phosphatase controls responses to aversive stimuli: implication for ethanol drinking. Legastelois R, Darcq E, Wegner SA, Lombroso PJ, Ron D. PLoS One. 2015; 2015 May 20. PMID: 25992601.", + "Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP. Baguley TD, Nairn AC, Lombroso PJ, Ellman JA. Bioorg Med Chem Lett. 2015 Mar 1; 2015 Jan 20. PMID: 25666825.", + "STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease. Kurup PK, Xu J, Videira RA, Ononenyi C, Baltazar G, Lombroso PJ, Nairn AC. Proc Natl Acad Sci U S A. 2015 Jan 27; 2015 Jan 12. PMID: 25583483.", + "Disruption of striatal-enriched protein tyrosine phosphatase (STEP) function in neuropsychiatric disorders. Karasawa T, Lombroso PJ. Neurosci Res. 2014 Dec; 2014 Sep 10. PMID: 25218562.", + "Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease. Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Ononenyi C, Foscue E, Anderson GM, Gresack J, Cuny GD, Glicksman MA, Greengard P, Lam TT, Tautz L, Nairn AC, Ellman JA, Lombroso PJ. PLoS Biol. 2014 Aug; 2014 Aug 5. PMID: 25093460.", + "Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP. Chiodi V, Mallozzi C, Ferrante A, Chen JF, Lombroso PJ, Di Stasi AM, Popoli P, Domenici MR. Neuropsychopharmacology. 2014 Feb; 2013 Aug 30. PMID: 23989619.", + "Neuroprotective role of a brain-enriched tyrosine phosphatase, STEP, in focal cerebral ischemia. Deb I, Manhas N, Poddar R, Rajagopal S, Allan AM, Lombroso PJ, Rosenberg GA, Candelario-Jalil E, Paul S. J Neurosci. 2013 Nov 6. PMID: 24198371.", + "Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase. Baguley TD, Xu HC, Chatterjee M, Nairn AC, Lombroso PJ, Ellman JA. J Med Chem. 2013 Oct 10; 2013 Oct 1. PMID: 24083656.", + "A common STEP in the synaptic pathology of diverse neuropsychiatric disorders. Johnson MA, Lombroso PJ. Yale J Biol Med. 2012 Dec; 2012 Dec 13. PMID: 23239949.", + "Striatal-enriched protein-tyrosine phosphatase (STEP) regulates Pyk2 kinase activity. Xu J, Kurup P, Bartos JA, Patriarchi T, Hell JW, Lombroso PJ. J Biol Chem. 2012 Jun 15; 2012 Apr 27. PMID: 22544749.", + "Striatal-enriched protein tyrosine phosphatase in Alzheimer's disease. Xu J, Kurup P, Nairn AC, Lombroso PJ. Adv Pharmacol. 2012. PMID: 22840751.", + "Therapeutic implications for striatal-enriched protein tyrosine phosphatase (STEP) in neuropsychiatric disorders. Goebel-Goody SM, Baum M, Paspalas CD, Fernandez SM, Carty NC, Kurup P, Lombroso PJ. Pharmacol Rev. 2012 Jan; 2011 Nov 16. PMID: 22090472.", + "Taking STEPs forward to understand fragile X syndrome. Goebel-Goody SM, Lombroso PJ. Results Probl Cell Differ. 2012. PMID: 22009355.", + "Reduced levels of the tyrosine phosphatase STEP block β amyloid-mediated GluA1/GluA2 receptor internalization. Zhang Y, Kurup P, Xu J, Anderson GM, Greengard P, Nairn AC, Lombroso PJ. J Neurochem. 2011 Nov; 2011 Sep 21. PMID: 21883219.", + "Striatal-enriched protein tyrosine phosphatase (STEP) knockout mice have enhanced hippocampal memory. Venkitaramani DV, Moura PJ, Picciotto MR, Lombroso PJ. Eur J Neurosci. 2011 Jun; 2011 Apr 19. PMID: 21501258.", + "Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model. Zhang Y, Kurup P, Xu J, Carty N, Fernandez SM, Nygaard HB, Pittenger C, Greengard P, Strittmatter SM, Nairn AC, Lombroso PJ. Proc Natl Acad Sci U S A. 2010 Nov 2; 2010 Oct 18. PMID: 20956308.", + "The role of STEP in Alzheimer's disease. Kurup P, Zhang Y, Venkitaramani DV, Xu J, Lombroso PJ. Channels (Austin). 2010 Sep-Oct; 2010 Sep 6. PMID: 20699650.", + "Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61. Kurup P, Zhang Y, Xu J, Venkitaramani DV, Haroutunian V, Greengard P, Nairn AC, Lombroso PJ. J Neurosci. 2010 Apr 28. PMID: 20427654.", + "Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP. Xu J, Kurup P, Zhang Y, Goebel-Goody SM, Wu PH, Hawasli AH, Baum ML, Bibb JA, Lombroso PJ. J Neurosci. 2009 Jul 22. PMID: 19625523.", + "A substrate trapping mutant form of striatal-enriched protein tyrosine phosphatase prevents amphetamine-induced stereotypies and long-term potentiation in the striatum. Tashev R, Moura PJ, Venkitaramani DV, Prosperetti C, Centonze D, Paul S, Lombroso PJ. Biol Psychiatry. 2009 Apr 15; 2008 Nov 20. PMID: 19026408.", + "Knockout of striatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation. Venkitaramani DV, Paul S, Zhang Y, Kurup P, Ding L, Tressler L, Allen M, Sacca R, Picciotto MR, Lombroso PJ. Synapse. 2009 Jan. PMID: 18932218.", + "The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation. Zhang Y, Venkitaramani DV, Gladding CM, Zhang Y, Kurup P, Molnar E, Collingridge GL, Lombroso PJ. J Neurosci. 2008 Oct 15. PMID: 18923032.", + "Translation of striatal-enriched protein tyrosine phosphatase (STEP) after beta1-adrenergic receptor stimulation. Hu Y, Zhang Y, Venkitaramani DV, Lombroso PJ. J Neurochem. 2007 Oct; 2007 Jul 10. PMID: 17623046.", + "The striatal-enriched protein tyrosine phosphatase gates long-term potentiation and fear memory in the lateral amygdala. Paul S, Olausson P, Venkitaramani DV, Ruchkina I, Moran TD, Tronson N, Mills E, Hakim S, Salter MW, Taylor JR, Lombroso PJ. Biol Psychiatry. 2007 May 1; 2006 Nov 1. PMID: 17081505.", + "NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Paul S, Nairn AC, Wang P, Lombroso PJ. Nat Neurosci. 2003 Jan. PMID: 12483215.", + "Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420. Nguyen TH, Liu J, Lombroso PJ. J Biol Chem. 2002 Jul 5; 2002 Apr 30. PMID: 11983687.", + "Sterling Hall of Medicine 333 Cedar Street New Haven, CT 06520-8023", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Longbrake Lab", + "lab_url": "https://medicine.yale.edu/lab/longbrake/", + "research_bio": "INFORMATION FOR Copy Link Copy Link Copy Link Associate Professor of Neurology; Director, Clinical Research, Neuroimmunology; Director, Fellowship Program, Multiple Sclerosis & Other Inflammatory Brain Disease; Interim Academic Chief, Neuroimmunology, Neurology Clinical Research Coordinator Neuroimmunology Clinical Research Manager Clinical Research Coordinator, Neurology Postgraduate Associate Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/longbrake/publications", + "publications": [ + "Yale School of Medicine /", + "Neurology /", + "Research", + "Clinical Trials Enrolling Participants", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Clinical Trials Enrolling Participants", + "Publications", + "", + "", + "", + "", + "", + "", + "Automated segmentation of multiple sclerosis lesions, paramagnetic rims, and central vein sign on MRI provides reliable diagnostic biomarkers. Hu F, Ren Z, Chen L, Valcarcel AM, Dworkin J, Renner B, Daboul L, O'Donnell CM, Verter ED, Manning AR, Clark KA, Bae E, Chen C, Lou C, Satterthwaite TD, Shou H, Bilello M, Nakamura K, Bar-Or A, Calabresi PA, Freeman L, Henry RG, Longbrake EE, Oh J, Schindler MK, Absinta M, Solomon AJ, Sicotte NL, Ontaneda D, Reich DS, Sati P, Shinohara RT. Imaging Neurosci (Camb). 2025; 2025 Oct 10. PMID: 41089191.", + "Differential results of genetic risk scoring for multiple sclerosis in European and African American populations. Rivier CA, Xu L, Clocchiatti-Tuozzo S, Zhao H, Ohno-Machado L, Hafler DA, Falcone GJ, Longbrake EE. Mult Scler. 2025 Oct; 2025 Sep 24. PMID: 40991630.", + "Frequency and Diagnostic Implications of Paramagnetic Rim Lesions in People Presenting for Diagnosis to a Multiple Sclerosis Clinic. Renner B, Verter ED, Absinta M, Daboul L, Raza P, Martin ML, Cao Q, O'Donnell CM, Rodrigues PR, Ramos M, Prchkovska V, Derbyshire J, Azevedo CJ, Bar-Or A, Caverzasi E, Calabresi PA, Cree BAC, Freeman L, Henry RG, Longbrake EE, Oh J, Papinutto N, Pelletier D, Samudralwar RD, Schindler MK, Sotirchos ES, Sicotte NL, Solomon AJ, Shinohara RT, Reich DS, Ontaneda D, Sati P. Neurology. 2025 Sep 23; 2025 Sep 2. PMID: 40893055.", + "Long COVID in People With Multiple Sclerosis and Related Disorders: A Multicenter Cross-Sectional Study. Hu C, Son J, McAlpine L, Walker ELS, Dahl M, Song E, Ferreira Brito S, Kavak K, Onomichi K, Bar-Or A, Perrone C, Riley CS, Weinstock-Guttman B, De Jager PL, Longbrake EE, Xia Z. Ann Clin Transl Neurol. 2025 Sep 5; 2025 Sep 5. PMID: 40910585.", + "Efficacy and safety of sipavibart for prevention of COVID-19 in individuals who are immunocompromised (SUPERNOVA): a randomised, controlled, double-blind, phase 3 trial. Haidar G, Thomas S, Loubet P, Baker RI, Benfield T, Boonyaratanakornkit J, Kiertiburanakul S, Kim AHJ, Longbrake EE, Molina JM, Paredes R, Tucker D, Uriel A, Weinmann-Menke J, Aksyuk AA, Clegg LE, Currie A, Yang H, Flyrin K, Gibbs M, Shroff M, Perez JL, Chang LJ, Cohen TS. Lancet Infect Dis. 2025 Jul; 2025 Feb 24. PMID: 40015292.", + "Transcriptomic profiling after B cell depletion reveals central and peripheral immune cell changes in multiple sclerosis. Wei J, Moon J, Yasumizu Y, Zhang L, Radassi K, Buitrago-Pocasangre N, Deerhake ME, Strauli N, Chen CW, Herman A, Pedotti R, Raposo C, Yim I, Pappalardo J, Longbrake EE, Sumida TS, Axisa PP, Hafler DA. J Clin Invest. 2025 Jun 2; 2025 Mar 11. PMID: 40067358.", + "Evaluation of the relationship between brainstem lesions and apnea hypopnea index in patients with multiple sclerosis. Levit E, Cohen I, Mahajan A, Ulano A, Longbrake EE, Solomon AJ. Mult Scler. 2025 Jun; 2025 Mar 29. PMID: 40156308.", + "Inflamed Microglia like Macrophages in the Central Nervous System of Prodromal Parkinson's Disease. Zhang L, Yasumizu Y, Deerhake ME, Moon J, Buitrago-Pocasangre N, Russo A, Wang H, Zhu B, Seibyl JP, Reddy V, Wang Q, Spillantini MG, Posner DA, Clatworthy M, Sumida TS, Longbrake EE, Cedarbaum JM, Hafler DA. bioRxiv. 2025 May 21; 2025 May 21. PMID: 40475455.", + "Long COVID in people with multiple sclerosis and related disorders: a multicenter cross-sectional study. Hu C, Son J, McAlpine L, Walker EL, Dahl M, Song E, Ferreira Brito S, Kavak K, Onomichi K, Bar-Or A, Perrone C, Riley CS, Weinstock Guttman B, De Jager PL, Longbrake EE, Xia Z. medRxiv. 2025 May 21; 2025 May 21. PMID: 40475143.", + "Alterations in Gut Microbiome-Host Relationships After Immune Perturbation in Patients With Multiple Sclerosis. Gupta VK, Janda GS, Pump HK, Lele N, Cruz I, Cohen I, Ruff WE, Hafler DA, Sung J, Longbrake EE. Neurol Neuroimmunol Neuroinflamm. 2025 Mar; 2025 Jan 16. PMID: 39819054.", + "Real-world infection risk in multiple sclerosis patients on long-term immunomodulatory treatments. Lambert CM, Hussain T, Peters J, Longbrake EE. Mult Scler Relat Disord. 2025 Feb; 2024 Dec 24. PMID: 39755026.", + "Reliability of Central Vein Sign Imaging With 3T FLAIR* in a Multicenter Study. Martin ML, Cao Q, Luskin E, Renner B, Daboul L, O'Donnell CM, Rodrigues P, Derbyshire J, Azevedo CJ, Bar-Or A, Caverzasi E, Calabresi P, Cree BAC, Freeman L, Henry RG, Longbrake EE, Oh J, Papinutto N, Pelletier D, Prchkovska V, Ramos M, Samudralwar RD, Schindler MK, Sotirchos ES, Sicotte NL, Solomon AJ, Reich DS, Ontaneda D, Shinohara RT, Sati P. J Neuroimaging. 2025 Jan-Feb. PMID: 39838609.", + "Incorporation of the central vein sign into the McDonald criteria. Amin M, Nakamura K, Daboul L, O'Donnell C, Cao Q, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi PA, Cree BAC, Freeman L, Henry R, Longbrake EE, Oh J, Papinutto N, Pelletier D, Prčkovska V, Raza PC, Ramos M, Samudralwar R, Schindler M, Sotirchos ES, Sicotte N, Solomon AJ, Shinohara R, Reich DS, Sati P, Ontaneda D. Mult Scler Relat Disord. 2025 Jan; 2024 Nov 25. PMID: 39622133.", + "Real-World Safety and Effectiveness of Dimethyl Fumarate in Patients with MS: Results from the ESTEEM Phase 4 and PROCLAIM Phase 3 Studies with a Focus on Older Patients. Mao-Draayer Y, Bar-Or A, Balashov K, Foley J, Smoot K, Longbrake EE, Robertson D, Mendoza JP, Lewin JB, Everage N, Božin I, Lyons J, Mokliatchouk O, Bame E, Giuliani F. Adv Ther. 2025 Jan; 2024 Nov 21. PMID: 39570545.", + "Multicenter validation of automated detection of paramagnetic rim lesions on brain MRI in multiple sclerosis. Chen L, Ren Z, Clark KA, Lou C, Liu F, Cao Q, Manning AR, Martin ML, Luskin E, O'Donnell CM, Azevedo CJ, Calabresi PA, Freeman L, Henry RG, Longbrake EE, Oh J, Papinutto N, Bilello M, Song JW, Kaisey M, Sicotte NL, Reich DS, Solomon AJ, Ontaneda D, Sati P, Absinta M, Schindler MK, Shinohara RT. J Neuroimaging. 2024 Nov-Dec; 2024 Oct 15. PMID: 39410780.", + "Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis. Toljan K, Daboul L, Raza P, Martin ML, Cao Q, O'Donnell CM, Rodrigues P, Derbyshire J, Azevedo CJ, Bar-Or A, Caverzasi E, Calabresi PA, Cree BA, Freeman L, Henry RG, Longbrake EE, Oh J, Papinutto N, Pelletier D, Samudralwar RD, Schindler MK, Sotirchos ES, Sicotte NL, Solomon AJ, Shinohara RT, Reich DS, Sati P, Ontaneda D. Mult Scler. 2024 Sep; 2024 Sep 5. PMID: 39234802.", + "Gut Microbiome Wellness Index 2 enhances health status prediction from gut microbiome taxonomic profiles. Chang D, Gupta VK, Hur B, Cobo-López S, Cunningham KY, Han NS, Lee I, Kronzer VL, Teigen LM, Karnatovskaia LV, Longbrake EE, Davis JM 3rd, Nelson H, Sung J. Nat Commun. 2024 Aug 28; 2024 Aug 28. PMID: 39198444.", + "Meta-analysis identifies common gut microbiota associated with multiple sclerosis. Lin Q, Dorsett Y, Mirza A, Tremlett H, Piccio L, Longbrake EE, Choileain SN, Hafler DA, Cox LM, Weiner HL, Yamamura T, Chen K, Wu Y, Zhou Y. Genome Med. 2024 Jul 31; 2024 Jul 31. PMID: 39085949.", + "Choroid plexus volume differentiates MS from its mimics. Levit E, Ren Z, Gonzenbach V, Azevedo CJ, Calabresi PA, Cree BA, Freeman L, Longbrake EE, Oh J, Schindler MK, Sicotte NL, Reich DS, Ontaneda D, Sati P, Cao Q, Shinohara RT, Solomon AJ. Mult Scler. 2024 Jul; 2024 Mar 13. PMID: 38481081.", + "Shifting our attention earlier in the multiple sclerosis disease course. Epstein SE, Longbrake EE. Curr Opin Neurol. 2024 Jun 1; 2024 Mar 28. PMID: 38546031.", + "Emerging Cerebrospinal Fluid Biomarkers of Disease Activity and Progression in Multiple Sclerosis. Cross AH, Gelfand JM, Thebault S, Bennett JL, von Büdingen HC, Cameron B, Carruthers R, Edwards K, Fallis R, Gerstein R, Giacomini PS, Greenberg B, Hafler DA, Ionete C, Kaunzner UW, Kodama L, Lock C, Longbrake EE, Musch B, Pardo G, Piehl F, Weber MS, Yuen S, Ziemssen T, Bose G, Freedman MS, Anania VG, Ramesh A, Winger RC, Jia X, Herman A, Harp C, Bar-Or A. JAMA Neurol. 2024 Mar 11; 2024 Mar 11. PMID: 38466277.", + "A Noncanonical CD56dimCD16dim/- NK Cell Subset Indicative of Prior Cytotoxic Activity Is Elevated in Patients with Autoantibody-Mediated Neurologic Diseases. Yandamuri SS, Filipek B, Lele N, Cohen I, Bennett JL, Nowak RJ, Sotirchos ES, Longbrake EE, Mace EM, O'Connor KC. J Immunol. 2024 Mar 1. PMID: 38251887.", + "Systems Analysis of Immune Changes after B-cell Depletion in Autoimmune Multiple Sclerosis. Wei J, Moon J, Yasumizu Y, Zhang L, Radassi K, Buitrago-Pocasangre N, Deerhake ME, Strauli N, Chan A, Herman A, Pedotte R, Raposo C, Tackenberg B, Yim I, Pappalardo J, Longbrake EE, Sumida TS, Axisa PP, Hafler DA. bioRxiv. 2024 Feb 9; 2024 Feb 9. PMID: 38370778.", + "Impact of the COVID-19 Pandemic on the Personal Networks and Neurological Outcomes of People With Multiple Sclerosis: Cross-Sectional and Longitudinal Case-Control Study. Riley C, Venkatesh S, Dhand A, Doshi N, Kavak K, Levit E, Perrone C, Weinstock-Guttman B, Longbrake E, De Jager P, Xia Z. JMIR Public Health Surveill. 2024 Feb 6; 2024 Feb 6. PMID: 38319703.", + "A multicenter pilot study evaluating simplified central vein assessment for the diagnosis of multiple sclerosis. Daboul L, O'Donnell CM, Amin M, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi PA, Cree BA, Freeman L, Henry RG, Longbrake EE, Oh J, Papinutto N, Pelletier D, Prchkovska V, Raza P, Ramos M, Samudralwar RD, Schindler MK, Sotirchos ES, Sicotte NL, Solomon AJ, Shinohara RT, Reich DS, Sati P, Ontaneda D. Mult Scler. 2024 Jan; 2023 Dec 13. PMID: 38088067.", + "Secondary hypogammaglobulinemia in patients with multiple sclerosis on anti-CD20 therapy: Pathogenesis, risk of infection, and disease management. Alvarez E, Longbrake EE, Rammohan KW, Stankiewicz J, Hersh CM. Mult Scler Relat Disord. 2023 Nov; 2023 Sep 15. PMID: 37783194.", + "Anti-CD20 monoclonal antibody therapy in postpartum women with neurological conditions. Anderson A, Rowles W, Poole S, Balan A, Bevan C, Brandstadter R, Ciplea AI, Cooper J, Fabian M, Hale TW, Jacobs D, Kakara M, Krysko KM, Longbrake EE, Marcus J, Repovic P, Riley CS, Romeo AR, Rutatangwa A, West T, Hellwig K, LaHue SC, Bove R. Ann Clin Transl Neurol. 2023 Nov; 2023 Sep 7. PMID: 37675826.", + "Gut Microbiome Wellness Index 2 for Enhanced Health Status Prediction from Gut Microbiome Taxonomic Profiles. Chang D, Gupta VK, Hur B, Cobo-López S, Cunningham KY, Han NS, Lee I, Kronzer VL, Teigen LM, Karnatovskaia LV, Longbrake EE, Davis JM 3rd, Nelson H, Sung J. bioRxiv. 2023 Oct 2; 2023 Oct 2. PMID: 37873265.", + "Microfluidic Immuno-Serolomic Assay Reveals Systems Level Association with COVID-19 Pathology and Vaccine Protection. Kim D, Biancon G, Bai Z, VanOudenhove J, Liu Y, Kothari S, Gowda L, Kwan JM, Buitrago-Pocasangre NC, Lele N, Asashima H, Racke MK, Wilson JE, Givens TS, Tomayko MM, Schulz WL, Longbrake EE, Hafler DA, Halene S, Fan R. Small Methods. 2023 Oct; 2023 Jun 13. PMID: 37312418.", + "Early Treatment for Multiple Sclerosis: Time Is Brain. Longbrake EE, Kalincik T. Neurology. 2023 Sep 26; 2023 Jul 19. PMID: 37468283.", + "Influence of menstrual cycle and hormonal contraceptive use on MS symptom fluctuations: A pilot study. Taylor H, Alhasan S, Saleem M, Poole S, Jiang F, Longbrake EE, Bove R. Mult Scler Relat Disord. 2023 Sep; 2023 Jun 30. PMID: 37480738.", + "Prior cycles of anti-CD20 antibodies affect antibody responses after repeated SARS-CoV-2 mRNA vaccination. Asashima H, Kim D, Wang K, Lele N, Buitrago-Pocasangre NC, Lutz R, Cruz I, Raddassi K, Ruff WE, Racke MK, Wilson JE, Givens TS, Grifoni A, Weiskopf D, Sette A, Kleinstein SH, Montgomery RR, Shaw AC, Li F, Fan R, Hafler DA, Tomayko MM, Longbrake EE. JCI Insight. 2023 Aug 22; 2023 Aug 22. PMID: 37606046.", + "MOGAD patient autoantibodies induce complement, phagocytosis, and cellular cytotoxicity. Yandamuri SS, Filipek B, Obaid AH, Lele N, Thurman JM, Makhani N, Nowak RJ, Guo Y, Lucchinetti CF, Flanagan EP, Longbrake EE, O'Connor KC. JCI Insight. 2023 Jun 8; 2023 Jun 8. PMID: 37097758.", + "Time for the Next Step in Clinical Trial Evolution? Longbrake EE. Ann Neurol. 2023 Jun; 2023 Apr 10. PMID: 36976460.", + "Future of Neurology & Technology: Neuroimaging Made Accessible Using Low-Field, Portable MRI. Parasuram NR, Crawford AL, Mazurek MH, Chavva IR, Beekman R, Gilmore EJ, Petersen NH, Payabvash S, Sze G, Eugenio Iglesias J, Omay SB, Matouk C, Longbrake EE, de Havenon A, Schiff SJ, Rosen MS, Kimberly WT, Sheth KN. Neurology. 2023 May 30; 2023 Jan 31. PMID: 36720639.", + "Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity. Shinoda K, Li R, Rezk A, Mexhitaj I, Patterson KR, Kakara M, Zuroff L, Bennett JL, von Büdingen HC, Carruthers R, Edwards KR, Fallis R, Giacomini PS, Greenberg BM, Hafler DA, Ionete C, Kaunzner UW, Lock CB, Longbrake EE, Pardo G, Piehl F, Weber MS, Ziemssen T, Jacobs D, Gelfand JM, Cross AH, Cameron B, Musch B, Winger RC, Jia X, Harp CT, Herman A, Bar-Or A. Proc Natl Acad Sci U S A. 2023 Jan 17; 2023 Jan 12. PMID: 36634138.", + "Effect of GBCA Use on Detection and Diagnostic Performance of the Central Vein Sign: Evaluation Using a 3-T FLAIR* Sequence in Patients With Suspected Multiple Sclerosis. Daboul L, O'Donnell CM, Cao Q, Amin M, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi P, Cree BAC, Freeman L, Henry RG, Longbrake EE, Nakamura K, Oh J, Papinutto N, Pelletier D, Samudralwar RD, Suthiphosuwan S, Schindler MK, Sotirchos ES, Sicotte NL, Solomon AJ, Shinohara RT, Reich DS, Ontaneda D, Sati P. AJR Am J Roentgenol. 2023 Jan; 2022 Aug 17. PMID: 35975888.", + "Infection risk in a real-world cohort of patients treated with long-term B-cell depletion for autoimmune neurologic disease. Peters J, Longbrake EE. Mult Scler Relat Disord. 2022 Dec; 2022 Nov 5. PMID: 36544307.", + "High-Efficacy Therapies for Treatment-Naïve Individuals with Relapsing-Remitting Multiple Sclerosis. Freeman L, Longbrake EE, Coyle PK, Hendin B, Vollmer T. CNS Drugs. 2022 Dec; 2022 Nov 9. PMID: 36350491.", + "Impact of resilience, social support, and personality traits in patients with neuroinflammatory diseases during the COVID-19 pandemic. Jakimovski D, Kavak KS, Longbrake EE, Levit E, Perrone CM, Bar-Or A, Benedict RH, Riley CS, De Jager PL, Venkatesh S, Walker ELS, Xia Z, Weinstock-Guttman B. Mult Scler Relat Disord. 2022 Dec; 2022 Oct 9. PMID: 36283322.", + "The CELLO trial: Protocol of a planned phase 4 study to assess the efficacy of Ocrelizumab in patients with radiologically isolated syndrome. Longbrake EE, Hua LH, Mowry EM, Gauthier SA, Alvarez E, Cross AH, Pei J, Priest J, Raposo C, Hafler DA, Winger RC. Mult Scler Relat Disord. 2022 Dec; 2022 Aug 22. PMID: 36031693.", + "Impact of the COVID-19 Pandemic on Personal Networks and Neurological Outcomes of People with Multiple Sclerosis: A Case-Control Cross-sectional and Longitudinal Analysis. Riley CS, Venkatesh S, Dhand A, Doshi N, Kavak K, Levit EE, Perrone C, Weinstock-Guttman B, Longbrake EE, De Jager PL, Xia Z. medRxiv. 2022 Nov 29; 2022 Nov 29. PMID: 36203554.", + "Toward Precision Phenotyping of Multiple Sclerosis. Pitt D, Lo CH, Gauthier SA, Hickman RA, Longbrake E, Airas LM, Mao-Draayer Y, Riley C, De Jager PL, Wesley S, Boster A, Topalli I, Bagnato F, Mansoor M, Stuve O, Kister I, Pelletier D, Stathopoulos P, Dutta R, Lincoln MR. Neurol Neuroimmunol Neuroinflamm. 2022 Nov; 2022 Aug 30. PMID: 36041861.", + "Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis. Asashima H, Axisa PP, Pham THG, Longbrake EE, Ruff WE, Lele N, Cohen I, Raddassi K, Sumida TS, Hafler DA. J Clin Invest. 2022 Oct 17; 2022 Oct 17. PMID: 36250467.", + "Microfluidic immuno-serology assay revealed a limited diversity of protection against COVID-19 in patients with altered immunity. Kim D, Biancon G, Bai Z, VanOudenhove J, Liu Y, Kothari S, Gowda L, Kwan JM, Buitrago-Pocasangre NC, Lele N, Asashima H, Racke MK, Wilson JE, Givens TS, Tomayko MM, Schulz WL, Longbrake EE, Hafler DA, Halene S, Fan R. bioRxiv. 2022 Sep 2; 2022 Sep 2. PMID: 36093346.", + "Curriculum Innovations: Virtual Didactics as a Tool for Harmonizing Education About Rare Topics in Neuroimmunology. Peters J, Cohen JA, Corboy JR, Hopkins SE, Hua LH, Kakara M, McFaul D, Obeidat AZ, Yadav V, Longbrake EE. Neurol Educ. 2022 Sep. PMID: 38725979.", + "Myelin Oligodendrocyte Glycoprotein-Associated Disorders. Longbrake E. Continuum (Minneap Minn). 2022 Aug 1. PMID: 35938661.", + "The White Matter Rounds experience: The importance of a multidisciplinary network to accelerate the diagnostic process for adult patients with rare white matter disorders. Huang YT, Giacomini PS, Massie R, Venkateswaran S, Trudelle AM, Fadda G, Sharifian-Dorche M, Boudjani H, Poliquin-Lasnier L, Airas L, Saveriano AW, Ziller MG, Miller E, Martinez-Rios C, Wilson N, Davila J, Rush C, Longbrake EE, Longoni G, Macaron G, Bernard G, Tampieri D, Antel J, Brais B, La Piana R. Front Neurol. 2022; 2022 Jul 25. PMID: 35959404.", + "Seroconversion after COVID-19 vaccination for multiple sclerosis patients on high efficacy disease modifying medications. Levit E, Longbrake EE, Stoll SS. Mult Scler Relat Disord. 2022 Apr; 2022 Mar 3. PMID: 35276450.", + "Worsening physical functioning in patients with neuroinflammatory disease during the COVID-19 pandemic. Levit E, Cohen I, Dahl M, Edwards K, Weinstock-Guttman B, Ishikawa T, Kavak K, Leavitt V, Nelson K, Onomichi K, Bar-Or A, Perrone C, Riley C, Venkatesh S, De Jager PL, Xia Z, Longbrake EE. Mult Scler Relat Disord. 2022 Feb; 2022 Jan 4. PMID: 35016114.", + "Vaccination Against SARS-CoV-2 in Neuroinflammatory Disease: Early Safety/Tolerability Data. Epstein S, Xia Z, Lee AJ, Dahl M, Edwards K, Levit E, Longbrake EE, Perrone C, Kavak K, Weinstock-Guttman B, Diallo F, Ricci A, Riley CS, De Jager PL, Farber R, Wesley SF. Mult Scler Relat Disord. 2022 Jan; 2021 Dec 2. PMID: 34923427.", + "A New England COVID-19 Registry of Patients With CNS Demyelinating Disease: A Pilot Analysis. Money KM, Mahatoo A, Samaan S, Anand P, Baber U, Bailey M, Bakshi R, Bouley A, Bower A, Cahill J, Houtchens M, Katz J, Lathi E, Levit E, Longbrake EE, McAdams M, Napoli S, Raibagkar P, Wade P, Sloane JA. Neurol Neuroimmunol Neuroinflamm. 2021 Sep; 2021 Aug 2. PMID: 34341094.", + "(23)Na imaging: Worth its salt for understanding multiple sclerosis. Longbrake EE, Hafler DA. Proc Natl Acad Sci U S A. 2021 Aug 17. PMID: 34376559.", + "Neuroinflammation Associated With Tumor Necrosis Factor-α Inhibitor Exposure. Yu AW, Pecsok M, Longbrake EE, Wesley SF. Neurol Clin Pract. 2021 Aug. PMID: 34484946.", + "Consensus Curriculum for Fellowship Training in Multiple Sclerosis and Neuroimmunology. Hua LH, Obeidat AZ, Amezcua L, Cohen JA, Costello K, Dunn J, Gelfand JM, Goldman MD, Hopkins S, Jeffery D, Krieger S, Newsome SD, Shah S, Sicotte NL, Yadav V, Longbrake EE. Neurol Clin Pract. 2021 Aug. PMID: 34484933.", + "Influence of immunomodulatory drugs on the gut microbiota. Cohen I, Ruff WE, Longbrake EE. Transl Res. 2021 Jul; 2021 Jan 27. PMID: 33515779.", + "MOG-associated encephalitis following SARS-COV-2 infection. Peters J, Alhasan S, Vogels CBF, Grubaugh ND, Farhadian S, Longbrake EE. Mult Scler Relat Disord. 2021 May; 2021 Feb 23. PMID: 33647592.", + "Dimethyl fumarate treatment shifts the immune environment toward an anti-inflammatory cell profile while maintaining protective humoral immunity. Longbrake EE, Mao-Draayer Y, Cascione M, Zielinski T, Bame E, Brassat D, Chen C, Kapadia S, Mendoza JP, Miller C, Parks B, Xing D, Robertson D. Mult Scler. 2021 May; 2020 Jul 27. PMID: 32716690.", + "The Role of Immune Checkpoint Therapy in Propagating Neurologic Immune-Related Adverse Events: Inducing or \"Unmasking\" Autoimmunity? Gardin T, Longbrake EE. Neurology. 2021 Apr 20; 2021 Mar 16. PMID: 33727404.", + "Manifestations and impact of the COVID-19 pandemic in neuroinflammatory diseases. Levin SN, Venkatesh S, Nelson KE, Li Y, Aguerre I, Zhu W, Masown K, Rimmer KT, Diaconu CI, Onomichi KB, Leavitt VM, Levine LL, Strauss-Farber R, Vargas WS, Banwell B, Bar-Or A, Berger JR, Goodman AD, Longbrake EE, Oh J, Weinstock-Guttman B, Thakur KT, Edwards KR, Riley CS, Xia Z, De Jager PL. Ann Clin Transl Neurol. 2021 Apr; 2021 Feb 22. PMID: 33616290.", + "Therapeutic considerations in a case of progressive encephalomyelitis with rigidity and myoclonus. Gluck L, Hernandez AL, Wesley SF, Fulbright RK, Longbrake EE, Stathopoulos P. J Neurol Sci. 2020 Sep 15; 2020 Jun 18. PMID: 32593886.", + "Outcomes and future directions for neuroimmunology/multiple sclerosis fellowship training: Survey of recent trainees. Hua LH, Obeidat AZ, Longbrake EE. Mult Scler Relat Disord. 2020 Sep; 2020 Jun 10. PMID: 32585616.", + "Sex effects across the lifespan in women with multiple sclerosis. Krysko KM, Graves JS, Dobson R, Altintas A, Amato MP, Bernard J, Bonavita S, Bove R, Cavalla P, Clerico M, Corona T, Doshi A, Fragoso Y, Jacobs D, Jokubaitis V, Landi D, Llamosa G, Longbrake EE, Maillart E, Marta M, Midaglia L, Shah S, Tintore M, van der Walt A, Voskuhl R, Wang Y, Zabad RK, Zeydan B, Houtchens M, Hellwig K. Ther Adv Neurol Disord. 2020; 2020 Jul 1. PMID: 32655689.", + "Education Research: Multiple sclerosis and neuroimmunology fellowship training status in the United States. Obeidat AZ, Jassam YN, Hua LH, Cutter G, Ford CC, Halper J, Lisak RP, Sicotte NL, Longbrake EE. Neurology. 2020 Mar 17; 2020 Feb 27. PMID: 32107321.", + "CXCR3+ T cells in multiple sclerosis correlate with reduced diversity of the gut microbiome. Choileáin SN, Kleinewietfeld M, Raddassi K, Hafler DA, Ruff WE, Longbrake EE. J Transl Autoimmun. 2020; 2019 Dec 20. PMID: 32743517.", + "Siponimod Chips Away at Progressive MS. Longbrake EE, Hafler DA. Cell. 2019 Dec 12; 2019 Dec 12. PMID: 31951523.", + "Streamlined EDSS for use in multiple sclerosis clinical practice: Development and cross-sectional comparison to EDSS. Baldassari LE, Salter AR, Longbrake EE, Cross AH, Naismith RT. Mult Scler. 2018 Sep; 2017 Aug 2. PMID: 28766993.", + "Dimethyl fumarate induces changes in B- and T-lymphocyte function independent of the effects on absolute lymphocyte count. Longbrake EE, Cantoni C, Chahin S, Cignarella F, Cross AH, Piccio L. Mult Scler. 2018 May; 2017 May 8. PMID: 28480794.", + "Effectiveness of alternative dose fingolimod for multiple sclerosis. Longbrake EE, Kantor D, Pawate S, Bradshaw MJ, von Geldern G, Chahin S, Cross AH, Parks BJ, Rice M, Khoury SJ, Yamout B, Zeineddine M, Russell-Giller S, Caminero-Rodriguez A, Edwards K, Lathi E, VanderKodde D, Meador W, Berkovich R, Ge L, Bacon TE, Kister I. Neurol Clin Pract. 2018 Apr. PMID: 29708225.", + "A Neurology Clerkship Curriculum Using Video-Based Lectures and Just-in-Time Teaching (JiTT). Dominguez M, DiCapua D, Leydon G, Loomis C, Longbrake EE, Schaefer SM, Becker KP, Detyniecki K, Gottschalk C, Salardini A, Encandela JA, Moeller JJ. MedEdPORTAL. 2018 Mar 16; 2018 Mar 16. PMID: 30800891.", + "Quantitative visual tests after poorly recovered optic neuritis due to multiple sclerosis. Longbrake EE, Lancia S, Tutlam N, Trinkaus K, Naismith RT. Mult Scler Relat Disord. 2016 Nov; 2016 Nov 4. PMID: 27919490.", + "The contemporary spectrum of multiple sclerosis misdiagnosis: A multicenter study. Solomon AJ, Bourdette DN, Cross AH, Applebee A, Skidd PM, Howard DB, Spain RI, Cameron MH, Kim E, Mass MK, Yadav V, Whitham RH, Longbrake EE, Naismith RT, Wu GF, Parks BJ, Wingerchuk DM, Rabin BL, Toledano M, Tobin WO, Kantarci OH, Carter JL, Keegan BM, Weinshenker BG. Neurology. 2016 Sep 27; 2016 Aug 31. PMID: 27581217.", + "Linking Genotype to Clinical Phenotype in Multiple Sclerosis: In Search of the Holy Grail. Longbrake EE, Hafler DA. JAMA Neurol. 2016 Jul 1. PMID: 27244583.", + "An older dog with newer tricks: Predicting efficacy of IFN-β treatment for multiple sclerosis. Wu GF, Longbrake EE. Neurol Neuroimmunol Neuroinflamm. 2016 Apr; 2016 Apr 7. PMID: 27110589.", + "Effect of Multiple Sclerosis Disease-Modifying Therapies on B Cells and Humoral Immunity. Longbrake EE, Cross AH. JAMA Neurol. 2016 Feb. PMID: 26720195.", + "Efficacy and tolerability of oral versus injectable disease-modifying therapies for multiple sclerosis in clinical practice. Longbrake EE, Cross AH, Salter A. Mult Scler J Exp Transl Clin. 2016 Jan-Dec; 2016 Nov 1. PMID: 28280599.", + "Dimethyl fumarate associated lymphopenia in clinical practice. Longbrake EE, Cross AH. Mult Scler. 2015 May; 2014 Nov 28. PMID: 25432948.", + "Dimethyl fumarate-associated lymphopenia: Risk factors and clinical significance. Longbrake EE, Naismith RT, Parks BJ, Wu GF, Cross AH. Mult Scler J Exp Transl Clin. 2015 Jan-Dec; 2015 Jul 31. PMID: 26550483.", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Louvi Laboratory", + "lab_url": "https://medicine.yale.edu/lab/louvi/", + "research_bio": "INFORMATION FOR Copy Link Our laboratory is interested in understanding the molecular mechanisms governing the development of the mammalian brain and how the perturbation of basic biological processes leads to clinically significant brain pathologies. Working closely with other research groups within the Yale Program on Neurogenetics,we studythe cellular and molecular mechanisms underlying neurovascular and structural brain disorders associated with specific genetic lesions, aiming to gain insight into fundamental neurodevelopmental processes and to obtain information relevant for the design of rational therapeutic approaches. Copy Link Angeliki Louvi is a Professor atYale School of Medicine, Deputy Director of theMD-PhD Program, and a member of the Yale Program on Neurogenetics and theInterdepartmental Neuroscience Program. She obtained her PhD from theDepartment of Genetics and Developmentat Columbia University Irving Medical Center and did post-doctoral work at theÉcole normale supérieureand at theUniversity of Chicago. She came to Yale in 2004. Yale researchers may have found a treatment target for a spectrum of genetic disorders that lead to brain malformations, seizures, and intellectual disability. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/louvi/publications/", + "publications": [ + "Yale School of Medicine /", + "Neurosurgery /", + "Research Structural Brain Disorders Cerebral Cavernous Malformations (CCM) Notch Lineages in the CNS CADASIL", + "Structural Brain Disorders", + "Cerebral Cavernous Malformations (CCM)", + "Notch Lineages in the CNS", + "CADASIL", + "Closer to Free", + "Lab Members Former Members", + "Former Members", + "Fondation Santé", + "Publications", + "Contact Us", + "The Notch Meeting", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Lab Members", + "Publications", + "The Notch Meeting", + "Closer to Free", + "Fondation Santé", + "Contact Us", + "", + "", + "", + "", + "", + "", + "A Human Neural Tube Model Using 4D Self-Folding Smart Scaffolds. Dell'Amico C, Chiesa I, Toffano A, Esposito A, Mancini P, Magliaro C, Louvi A, De Maria C, Onorati M. Adv Healthc Mater. 2025 Oct 23; 2025 Oct 23. PMID: 41126690.", + "Dysregulation of mTOR signalling is a converging mechanism in lissencephaly. Zhang C, Liang D, Ercan-Sencicek AG, Bulut AS, Cortes J, Cheng IQ, Henegariu O, Nishimura S, Wang X, Peksen AB, Takeo Y, Caglar C, Lam TT, Koroglu MN, Narayanan A, Lopez-Giraldez F, Miyagishima DF, Mishra-Gorur K, Barak T, Yasuno K, Erson-Omay EZ, Yalcinkaya C, Wang G, Mane S, Kaymakcalan H, Guzel A, Caglayan AO, Tuysuz B, Sestan N, Gunel M, Louvi A, Bilguvar K. Nature. 2025 Feb; 2025 Jan 1. PMID: 39743596.", + "Reply to Pisan et al.: Pathogenicity of inherited TRAF7 mutations in congenital heart disease. Mishra-Gorur K, Barak T, Kaulen LD, Henegariu O, Jin SC, Aguilera SM, Yalbir E, Goles G, Nishimura S, Miyagishima D, Djenoune L, Altinok S, Rai DK, Viviano S, Prendergast A, Zerillo C, Ozcan K, Baran B, Sencar L, Goc N, Yarman Y, Ercan-Encicek AG, Bilguvar K, Lifton RP, Moliterno J, Louvi A, Yuan S, Deniz E, Brueckner M, Gunel M. Proc Natl Acad Sci U S A. 2024 Mar 19; 2024 Mar 11. PMID: 38466853.", + "Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas. Youngblood MW, Erson-Omay Z, Li C, Najem H, Coșkun S, Tyrtova E, Montejo JD, Miyagishima DF, Barak T, Nishimura S, Harmancı AS, Clark VE, Duran D, Huttner A, Avşar T, Bayri Y, Schramm J, Boetto J, Peyre M, Riche M, Goldbrunner R, Amankulor N, Louvi A, Bilgüvar K, Pamir MN, Özduman K, Kilic T, Knight JR, Simon M, Horbinski C, Kalamarides M, Timmer M, Heimberger AB, Mishra-Gorur K, Moliterno J, Yasuno K, Günel M. Nat Commun. 2023 Oct 7; 2023 Oct 7. PMID: 37805627.", + "Microcephaly-associated protein WDR62 shuttles from the Golgi apparatus to the spindle poles in human neural progenitors. Dell'Amico C, Angulo Salavarria MM, Takeo Y, Saotome I, Dell'Anno MT, Galimberti M, Pellegrino E, Cattaneo E, Louvi A, Onorati M. Elife. 2023 Jun 5; 2023 Jun 5. PMID: 37272619.", + "Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease. Mishra-Gorur K, Barak T, Kaulen LD, Henegariu O, Jin SC, Aguilera SM, Yalbir E, Goles G, Nishimura S, Miyagishima D, Djenoune L, Altinok S, Rai DK, Viviano S, Prendergast A, Zerillo C, Ozcan K, Baran B, Sencar L, Goc N, Yarman Y, Ercan-Sencicek AG, Bilguvar K, Lifton RP, Moliterno J, Louvi A, Yuan S, Deniz E, Brueckner M, Gunel M. Proc Natl Acad Sci U S A. 2023 Apr 18; 2023 Apr 12. PMID: 37043537.", + "Altered Expression of Several Molecular Mediators of Cerebrospinal Fluid Production in Hyp Mice. Kaplan J, Tommasini S, Yao GQ, Zhu M, Nishimura S, Ghazarian S, Louvi A, Insogna K. J Endocr Soc. 2023 Feb 9; 2023 Feb 6. PMID: 36819458.", + "Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells. Parmigiani E, Ivanek R, Rolando C, Hafen K, Turchinovich G, Lehmann FM, Gerber A, Brkic S, Frank S, Meyer SC, Wakimoto H, Günel M, Louvi A, Mariani L, Finke D, Holländer G, Hutter G, Tussiwand R, Taylor V, Giachino C. Dev Cell. 2022 Aug 8; 2022 Jul 7. PMID: 35803280.", + "Cellular Origin of Sporadic CCMs. Reply. Peyre M, Louvi A, Kalamarides M. N Engl J Med. 2022 Mar 31. PMID: 35353973.", + "Modeling uniquely human gene regulatory function via targeted humanization of the mouse genome. Dutrow EV, Emera D, Yim K, Uebbing S, Kocher AA, Krenzer M, Nottoli T, Burkhardt DB, Krishnaswamy S, Louvi A, Noonan JP. Nat Commun. 2022 Jan 13; 2022 Jan 13. PMID: 35027568.", + "PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans. Barak T, Ristori E, Ercan-Sencicek AG, Miyagishima DF, Nelson-Williams C, Dong W, Jin SC, Prendergast A, Armero W, Henegariu O, Erson-Omay EZ, Harmancı AS, Guy M, Gültekin B, Kilic D, Rai DK, Goc N, Aguilera SM, Gülez B, Altinok S, Ozcan K, Yarman Y, Coskun S, Sempou E, Deniz E, Hintzen J, Cox A, Fomchenko E, Jung SW, Ozturk AK, Louvi A, Bilgüvar K, Connolly ES Jr, Khokha MK, Kahle KT, Yasuno K, Lifton RP, Mishra-Gorur K, Nicoli S, Günel M. Nat Med. 2021 Dec; 2021 Dec 9. PMID: 34887573.", + "Somatic PIK3CA Mutations in Sporadic Cerebral Cavernous Malformations. Peyre M, Miyagishima D, Bielle F, Chapon F, Sierant M, Venot Q, Lerond J, Marijon P, Abi-Jaoude S, Le Van T, Labreche K, Houlston R, Faisant M, Clémenceau S, Boch AL, Nouet A, Carpentier A, Boetto J, Louvi A, Kalamarides M. N Engl J Med. 2021 Sep 9. PMID: 34496175.", + "Neuroinvasion of SARS-CoV-2 in human and mouse brain. Song E, Zhang C, Israelow B, Lu-Culligan A, Prado AV, Skriabine S, Lu P, Weizman OE, Liu F, Dai Y, Szigeti-Buck K, Yasumoto Y, Wang G, Castaldi C, Heltke J, Ng E, Wheeler J, Alfajaro MM, Levavasseur E, Fontes B, Ravindra NG, Van Dijk D, Mane S, Gunel M, Ring A, Kazmi SAJ, Zhang K, Wilen CB, Horvath TL, Plu I, Haik S, Thomas JL, Louvi A, Farhadian SF, Huttner A, Seilhean D, Renier N, Bilguvar K, Iwasaki A. J Exp Med. 2021 Mar 1. PMID: 33433624.", + "Neuroinvasion of SARS-CoV-2 in human and mouse brain. Song E, Zhang C, Israelow B, Lu-Culligan A, Prado AV, Skriabine S, Lu P, Weizman OE, Liu F, Dai Y, Szigeti-Buck K, Yasumoto Y, Wang G, Castaldi C, Heltke J, Ng E, Wheeler J, Alfajaro MM, Levavasseur E, Fontes B, Ravindra NG, Van Dijk D, Mane S, Gunel M, Ring A, Kazmi SAJ, Zhang K, Wilen CB, Horvath TL, Plu I, Haik S, Thomas JL, Louvi A, Farhadian SF, Huttner A, Seilhean D, Renier N, Bilguvar K, Iwasaki A. bioRxiv. 2020 Sep 8; 2020 Sep 8. PMID: 32935108.", + "The Notch pathway in CNS homeostasis and neurodegeneration. Ho DM, Artavanis-Tsakonas S, Louvi A. Wiley Interdiscip Rev Dev Biol. 2020 Jan; 2019 Sep 10. PMID: 31502763.", + "Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus. Zhang R, Boareto M, Engler A, Louvi A, Giachino C, Iber D, Taylor V. Cell Rep. 2019 Aug 6. PMID: 31390563.", + "Cerebrovascular disorders associated with genetic lesions. Karschnia P, Nishimura S, Louvi A. Cell Mol Life Sci. 2019 Jan; 2018 Oct 16. PMID: 30327838.", + "Notch2 Signaling Maintains NSC Quiescence in the Murine Ventricular-Subventricular Zone. Engler A, Rolando C, Giachino C, Saotome I, Erni A, Brien C, Zhang R, Zimber-Strobl U, Radtke F, Artavanis-Tsakonas S, Louvi A, Taylor V. Cell Rep. 2018 Jan 23; 2018 Jan 28. PMID: 29386140.", + "Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis. Gifford GB, Demitrack ES, Keeley TM, Tam A, La Cunza N, Dedhia PH, Spence JR, Simeone DM, Saotome I, Louvi A, Siebel CW, Samuelson LC. Gut. 2017 Jun; 2016 Mar 1. PMID: 26933171.", + "Combined HMG-COA reductase and prenylation inhibition in treatment of CCM. Nishimura S, Mishra-Gorur K, Park J, Surovtseva YV, Sebti SM, Levchenko A, Louvi A, Gunel M. Proc Natl Acad Sci U S A. 2017 May 23; 2017 May 12. PMID: 28500274.", + "Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly. Sgourdou P, Mishra-Gorur K, Saotome I, Henagariu O, Tuysuz B, Campos C, Ishigame K, Giannikou K, Quon JL, Sestan N, Caglayan AO, Gunel M, Louvi A. Sci Rep. 2017 Mar 8; 2017 Mar 8. PMID: 28272472.", + "B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models. Shi C, Shenkar R, Zeineddine HA, Girard R, Fam MD, Austin C, Moore T, Lightle R, Zhang L, Wu M, Cao Y, Gunel M, Louvi A, Rorrer A, Gallione C, Marchuk DA, Awad IA. J Neuroimmune Pharmacol. 2016 Jun; 2016 Apr 16. PMID: 27086141.", + "Integrated genomic characterization of IDH1-mutant glioma malignant progression. Bai H, Harmancı AS, Erson-Omay EZ, Li J, Coşkun S, Simon M, Krischek B, Özduman K, Omay SB, Sorensen EA, Turcan Ş, Bakırcığlu M, Carrión-Grant G, Murray PB, Clark VE, Ercan-Sencicek AG, Knight J, Sencar L, Altınok S, Kaulen LD, Gülez B, Timmer M, Schramm J, Mishra-Gorur K, Henegariu O, Moliterno J, Louvi A, Chan TA, Tannheimer SL, Pamir MN, Vortmeyer AO, Bilguvar K, Yasuno K, Günel M. Nat Genet. 2016 Jan; 2015 Nov 30. PMID: 26618343.", + "Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ, Su B. Nat Commun. 2015 Aug 3; 2015 Aug 3. PMID: 26235885.", + "Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development. Nishimura S, Bilgüvar K, Ishigame K, Sestan N, Günel M, Louvi A. PLoS One. 2015; 2015 Apr 15. PMID: 25875176.", + "Mutations in KATNB1 Cause Complex Cerebral Malformations by Disrupting Asymmetrically Dividing Neural Progenitors. Mishra-Gorur K, Çağlayan AO, Schaffer AE, Chabu C, Henegariu O, Vonhoff F, Akgümüş GT, Nishimura S, Han W, Tu S, Baran B, Gümüş H, Dilber C, Zaki MS, Hossni HAA, Rivière JB, Kayserili H, Spencer EG, Rosti RÖ, Schroth J, Per H, Çağlar C, Çağlar Ç, Dölen D, Baranoski JF, Kumandaş S, Minja FJ, Erson-Omay EZ, Mane SM, Lifton RP, Xu T, Keshishian H, Dobyns WB, Chi NC, Šestan N, Louvi A, Bilgüvar K, Yasuno K, Gleeson JG, Günel M. Neuron. 2015 Jan 7; 2015 Jan 7. PMID: 29654772.", + "Mutations in KATNB1 cause complex cerebral malformations by disrupting asymmetrically dividing neural progenitors. Mishra-Gorur K, Çağlayan AO, Schaffer AE, Chabu C, Henegariu O, Vonhoff F, Akgümüş GT, Nishimura S, Han W, Tu S, Baran B, Gümüş H, Dilber C, Zaki MS, Hossni HA, Rivière JB, Kayserili H, Spencer EG, Rosti RÖ, Schroth J, Per H, Çağlar C, Çağlar Ç, Dölen D, Baranoski JF, Kumandaş S, Minja FJ, Erson-Omay EZ, Mane SM, Lifton RP, Xu T, Keshishian H, Dobyns WB, Chi NC, Šestan N, Louvi A, Bilgüvar K, Yasuno K, Gleeson JG, Günel M. Neuron. 2014 Dec 17. PMID: 25521378.", + "Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration. Louvi A, Nishimura S, Günel M. Development. 2014 Mar. PMID: 24595293.", + "Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration. Bilguvar K, Tyagi NK, Ozkara C, Tuysuz B, Bakircioglu M, Choi M, Delil S, Caglayan AO, Baranoski JF, Erturk O, Yalcinkaya C, Karacorlu M, Dincer A, Johnson MH, Mane S, Chandra SS, Louvi A, Boggon TJ, Lifton RP, Horwich AL, Gunel M. Proc Natl Acad Sci U S A. 2013 Feb 26; 2013 Jan 28. PMID: 23359680.", + "Notch and disease: a growing field. Louvi A, Artavanis-Tsakonas S. Semin Cell Dev Biol. 2012 Jun; 2012 Feb 20. PMID: 22373641.", + "WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP. J Biol Chem. 2011 Aug 26; 2011 Jul 6. PMID: 21733846.", + "Recessive LAMC3 mutations cause malformations of occipital cortical development. Barak T, Kwan KY, Louvi A, Demirbilek V, Saygı S, Tüysüz B, Choi M, Boyacı H, Doerschner K, Zhu Y, Kaymakçalan H, Yılmaz S, Bakırcıoğlu M, Cağlayan AO, Oztürk AK, Yasuno K, Brunken WJ, Atalar E, Yalçınkaya C, Dinçer A, Bronen RA, Mane S, Ozçelik T, Lifton RP, Sestan N, Bilgüvar K, Günel M. Nat Genet. 2011 Jun; 2011 May 15. PMID: 21572413.", + "Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease. Arboleda-Velasquez JF, Manent J, Lee JH, Tikka S, Ospina C, Vanderburg CR, Frosch MP, Rodríguez-Falcón M, Villen J, Gygi S, Lopera F, Kalimo H, Moskowitz MA, Ayata C, Louvi A, Artavanis-Tsakonas S. Proc Natl Acad Sci U S A. 2011 May 24; 2011 May 9. PMID: 21555590.", + "Cilia in the CNS: the quiet organelle claims center stage. Louvi A, Grove EA. Neuron. 2011 Mar 24. PMID: 21435552.", + "Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology. Louvi A, Chen L, Two AM, Zhang H, Min W, Günel M. Proc Natl Acad Sci U S A. 2011 Mar 1; 2011 Feb 14. PMID: 21321212.", + "Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice. Fre S, Hannezo E, Sale S, Huyghe M, Lafkas D, Kissel H, Louvi A, Greve J, Louvard D, Artavanis-Tsakonas S. PLoS One. 2011; 2011 Oct 3. PMID: 21991352.", + "Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations. Bilgüvar K, Oztürk AK, Louvi A, Kwan KY, Choi M, Tatli B, Yalnizoğlu D, Tüysüz B, Cağlayan AO, Gökben S, Kaymakçalan H, Barak T, Bakircioğlu M, Yasuno K, Ho W, Sanders S, Zhu Y, Yilmaz S, Dinçer A, Johnson MH, Bronen RA, Koçer N, Per H, Mane S, Pamir MN, Yalçinkaya C, Kumandaş S, Topçu M, Ozmen M, Sestan N, Lifton RP, State MW, Günel M. Nature. 2010 Sep 9; 2010 Aug 22. PMID: 20729831.", + "L-histidine decarboxylase and Tourette's syndrome. Ercan-Sencicek AG, Stillman AA, Ghosh AK, Bilguvar K, O'Roak BJ, Mason CE, Abbott T, Gupta A, King RA, Pauls DL, Tischfield JA, Heiman GA, Singer HS, Gilbert DL, Hoekstra PJ, Morgan TM, Loring E, Yasuno K, Fernandez T, Sanders S, Louvi A, Cho JH, Mane S, Colangelo CM, Biederer T, Lifton RP, Gunel M, State MW. N Engl J Med. 2010 May 20; 2010 May 5. PMID: 20445167.", + "Apoptotic functions of PDCD10/CCM3, the gene mutated in cerebral cavernous malformation 3. Chen L, Tanriover G, Yano H, Friedlander R, Louvi A, Gunel M. Stroke. 2009 Apr; 2009 Feb 26. PMID: 19246713.", + "Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome. Stillman AA, Krsnik Z, Sun J, Rasin MR, State MW, Sestan N, Louvi A. J Comp Neurol. 2009 Mar 1. PMID: 19105198.", + "Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. Shibazaki S, Yu Z, Nishio S, Tian X, Thomson RB, Mitobe M, Louvi A, Velazquez H, Ishibe S, Cantley LG, Igarashi P, Somlo S. Hum Mol Genet. 2008 Jun 1; 2008 Feb 7. PMID: 18263604.", + "PDCD10, the gene mutated in cerebral cavernous malformation 3, is expressed in the neurovascular unit. Tanriover G, Boylan AJ, Diluna ML, Pricola KL, Louvi A, Gunel M. Neurosurgery. 2008 Apr. PMID: 18496199.", + "Linking Notch signaling to ischemic stroke. Arboleda-Velasquez JF, Zhou Z, Shin HK, Louvi A, Kim HH, Savitz SI, Liao JK, Salomone S, Ayata C, Moskowitz MA, Artavanis-Tsakonas S. Proc Natl Acad Sci U S A. 2008 Mar 25; 2008 Mar 17. PMID: 18347334.", + "Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Bakkaloglu B, O'Roak BJ, Louvi A, Gupta AR, Abelson JF, Morgan TM, Chawarska K, Klin A, Ercan-Sencicek AG, Stillman AA, Tanriover G, Abrahams BS, Duvall JA, Robbins EM, Geschwind DH, Biederer T, Gunel M, Lifton RP, State MW. Am J Hum Genet. 2008 Jan. PMID: 18179895.", + "The derivatives of the Wnt3a lineage in the central nervous system. Louvi A, Yoshida M, Grove EA. J Comp Neurol. 2007 Oct 10. PMID: 17701978.", + "Notch signalling in vertebrate neural development. Louvi A, Artavanis-Tsakonas S. Nat Rev Neurosci. 2006 Feb. PMID: 16429119.", + "CCM2 expression parallels that of CCM1. Seker A, Pricola KL, Guclu B, Ozturk AK, Louvi A, Gunel M. Stroke. 2006 Feb; 2005 Dec 22. PMID: 16373645.", + "CADASIL: a critical look at a Notch disease. Louvi A, Arboleda-Velasquez JF, Artavanis-Tsakonas S. Dev Neurosci. 2006. PMID: 16508299.", + "WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability. Kahle KT, Rinehart J, de Los Heros P, Louvi A, Meade P, Vazquez N, Hebert SC, Gamba G, Gimenez I, Lifton RP. Proc Natl Acad Sci U S A. 2005 Nov 15; 2005 Nov 7. PMID: 16275911.", + "Sequence variants in SLITRK1 are associated with Tourette's syndrome. Abelson JF, Kwan KY, O'Roak BJ, Baek DY, Stillman AA, Morgan TM, Mathews CA, Pauls DL, Rasin MR, Gunel M, Davis NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure LS 4th, Kurlan R, Singer HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Sestan N, State MW. Science. 2005 Oct 14. PMID: 16224024.", + "Regionalization of the isthmic and cerebellar primordia. Narboux-Nême N, Louvi A, Alexandre P, Wassef M. Prog Brain Res. 2005. PMID: 15856550.", + "Presenilin 1 in migration and morphogenesis in the central nervous system. Louvi A, Sisodia SS, Grove EA. Development. 2004 Jul; 2004 May 26. PMID: 15163631.", + "The isthmic neuroepithelium is essential for cerebellar midline fusion. Louvi A, Alexandre P, Métin C, Wurst W, Wassef M. Development. 2003 Nov; 2003 Sep 24. PMID: 14507778.", + "Conserved expression of Hoxa1 in neurons at the ventral forebrain/midbrain boundary of vertebrates. McClintock JM, Jozefowicz C, Assimacopoulos S, Grove EA, Louvi A, Prince VE. Dev Genes Evol. 2003 Aug; 2003 May 14. PMID: 12748854.", + "Ectopic engrailed 1 expression in the dorsal midline causes cell death, abnormal differentiation of circumventricular organs and errors in axonal pathfinding. Louvi A, Wassef M. Development. 2000 Sep. PMID: 10952903.", + "Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development. Louvi A, Accili D, Efstratiadis A. Dev Biol. 1997 Sep 1. PMID: 9281335.", + "Insulin-like growth factor II stimulates cell proliferation through the insulin receptor. Morrione A, Valentinis B, Xu SQ, Yumet G, Louvi A, Efstratiadis A, Baserga R. Proc Natl Acad Sci U S A. 1997 Apr 15. PMID: 9108054.", + "Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes. Filson AJ, Louvi A, Efstratiadis A, Robertson EJ. Development. 1993 Jul. PMID: 8076514.", + "A cDNA clone encoding the ADP/ATP translocase of Drosophila melanogaster shows a high degree of similarity with the mammalian ADP/ATP translocases. Louvi A, Tsitilou SG. J Mol Evol. 1992 Jul. PMID: 1387687.", + "", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Lu Lab", + "lab_url": "https://medicine.yale.edu/lab/lu/", + "research_bio": "INFORMATION FOR Copy Link We are interested in using genomics to understand the role of non-coding RNAs in mammalian development and disease. Currently, we are focusing on the following topics. 1. Non-coding RNAs in blood stem cell differentiation and malignancies 2. MicroRNA-mediated control of embryonic stem cell fates 3. MicroRNA mechanisms. Copy Link Cell Differentiation; Hematologic Diseases; Hematopoiesis; Neoplasms; Cell Lineage Copy Link", + "publications_page": "https://medicine.yale.edu/lab/lu/publications", + "publications": null + }, + { + "lab_name": "LusKing Lab", + "lab_url": "https://medicine.yale.edu/lab/lusking/", + "research_bio": "INFORMATION FOR Copy Link The LusKing Lab investigates fundamental aspects of nuclear structure, dynamics, and integrity. We communicate our knowledge to both the scientific community and the general public. The lab provides a rich training environment for scientists at all levels to become interdisciplinary researchers capable of working effectively both individually and as a team. Our group is proud to effect positive change in our institutional, local, and national scientific communities. Copy Link We lead a passionate and diverse research group that equally emphasizes providing an environment for scientific research and training. As such, we strive to establish a community where scientific discovery is as passionately pursued as personal and professional ambition. Our mission is to make fundamental discoveries in the field of nuclear cell biology at the interface of basic and medical science. We work hard to not only advance scientific knowledge but also to disseminate that knowledge through engaging in scientific outreach and teaching. Further, we recognize that our potential can only be reached when the contributions of all members of our local communities are heard and valued. To this end, we strive to create a lab environment built fundamentally on respect, kindness, and compassion, in which all members are supported and celebrated. We seek to purposefully amplify and uplift the voices of all diverse perspectives and experiences. Copy Link We are recruiting new members to join our team at all career stages. If you are interested, please contactMeganand/orPatrick. See more details under “People”. 00:04:52 Copy Link Professor of Cell Biology and of Molecular, Cellular and Development Biology; Co-Leader, DNA Damage and Genome Integrity, Yale Cancer Center; Associate Cancer Center Director, Basic Science Professor of Cell Biology; Co-Director, Molecular Cell Biology, Genetics and Development Track, Cell Biology; Co-Director, Cellular, Molecular, and Quantitative Biology Training Program, Cell Biology Copy Link", + "publications_page": "https://medicine.yale.edu/lab/lusking/publications", + "publications": [ + "Yale School of Medicine /", + "Cell Biology /", + "People Environment/Training Join Our Team", + "Environment/Training", + "Join Our Team", + "Publications", + "Research", + "Lab Fun", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "People", + "Research", + "Lab Fun", + "News", + "Publications", + "", + "", + "", + "", + "", + "", + "Nuclear mechanics as a determinant of nuclear pore complex plasticity. Lusk CP, Morgan KJ, King MC. Nat Cell Biol. 2025 Oct; 2025 Sep 19. PMID: 40973737.", + "Clinical, neuropathological, and biochemical characterization of ALS in a large CHCHD10 R15L family. Kwan JY, Lantz CI, Korobeynikov VA, Snyder A, Huang X, Haselhuhn T, Dore KN, Madruga A, Danielian LE, Schindler AB, Chia R, Rasheed M, Crook J, Szabo M, Portley M, Sherer CM, King MC, Huang TH, Kosa P, Bielekova B, Ward ME, Grunseich C, Shneider NA, Traynor BJ, Narendra DP. medRxiv. 2025 Sep 26; 2025 Sep 26. PMID: 41040684.", + "Visualizing nuclear pore complex plasticity with pan-expansion microscopy. Morgan KJ, Carley E, Coyne AN, Rothstein JD, Lusk CP, King MC. J Cell Biol. 2025 Sep 1; 2025 Jun 12. PMID: 40504117.", + "Sense, plug, and seal: proteins as both rapid responders and constitutive barriers supporting organelle compartmentalization. King MC, Lusk CP, Ader NR. Mol Biol Cell. 2025 Aug 1; 2025 Jul 2. PMID: 40601416.", + "Coarse-grained chromatin dynamics by tracking multiple similarly labeled gene loci. Mader A, Rodriguez AI, Yuan T, Surovtsev I, King MC, Mochrie SGJ. Biophys J. 2025 Jul 1; 2025 May 13. PMID: 40369871.", + "Visualizing nuclear pore complex plasticity with pan-Expansion Microscopy. Morgan KJ, Carley E, Coyne AN, Rothstein JD, Lusk CP, King MC. bioRxiv. 2025 Apr 7; 2025 Apr 7. PMID: 39345637.", + "Coarse-grained chromatin dynamics by tracking multiple similarly labeled gene loci. Mader A, Rodriguez AI, Yuan T, Surovtsev I, King MC, Mochrie SGJ. bioRxiv. 2025 Mar 2; 2025 Mar 2. PMID: 40060506.", + "A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope. Mannino PJ, Perun A, Surovtsev IV, Ader NR, Shao L, Rodriguez EC, Melia TJ, King MC, Lusk CP. Nat Cell Biol. 2025 Mar; 2025 Feb 7. PMID: 39920277.", + "Nup107 contributes to the maternal-to-zygotic transition by preventing the premature nuclear export of pri-miR427. Kostiuk V, Kabir R, Levangie K, Empke S, Morgan K, Owens NDL, Lusk CP, Khokha MK. Development. 2025 Jan 15; 2025 Feb 4. PMID: 39791357.", + "A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope. Mannino PJ, Perun A, Surovtsev IV, Ader NR, Shao L, Rodriguez EC, Melia TJ, King MC, Lusk CP. bioRxiv. 2024 Nov 17; 2024 Nov 17. PMID: 38405892.", + "Channel width modulates the permeability of DNA origami-based nuclear pore mimics. Feng Q, Saladin M, Wu C, Cao E, Zheng W, Zhang A, Bhardwaj P, Li X, Shen Q, Kapinos LE, Kozai T, Mariappan M, Lusk CP, Xiong Y, Lim RYH, Lin C. Sci Adv. 2024 Nov 15; 2024 Nov 13. PMID: 39536094.", + "Cohesin distribution alone predicts chromatin organization in yeast via conserved-current loop extrusion. Yuan T, Yan H, Li KC, Surovtsev I, King MC, Mochrie SGJ. Genome Biol. 2024 Nov 14; 2024 Nov 14. PMID: 39543681.", + "A-tisket, a-tasket, what a beautiful nuclear basket. Lusk CP, King MC. Cell. 2024 Sep 19. PMID: 39303690.", + "BRCA1, BRCA2, and Associated Cancer Risks and Management for Male Patients: A Review. Cheng HH, Shevach JW, Castro E, Couch FJ, Domchek SM, Eeles RA, Giri VN, Hall MJ, King MC, Lin DW, Loeb S, Morgan TM, Offit K, Pritchard CC, Schaeffer EM, Szymaniak BM, Vassy JL, Katona BW, Maxwell KN. JAMA Oncol. 2024 Sep 1. PMID: 39052257.", + "The condensation of HP1α/Swi6 imparts nuclear stiffness. Williams JF, Surovtsev IV, Schreiner SM, Chen Z, Raiymbek G, Nguyen H, Hu Y, Biteen JS, Mochrie SGJ, Ragunathan K, King MC. Cell Rep. 2024 Jul 23; 2024 Jun 20. PMID: 38900638.", + "Identifying topologically associating domains using differential kernels. Maisuradze L, King MC, Surovtsev IV, Mochrie SGJ, Shattuck MD, O'Hern CS. PLoS Comput Biol. 2024 Jul; 2024 Jul 15. PMID: 39008525.", + "The multidimensional roles of intermediate filaments - bridging genetic diversity with form, functions, and targets. Lusk CP, Eriksson JE. Curr Opin Cell Biol. 2024 Jun; 2024 Apr 10. PMID: 38604107.", + "Channel width modulates the permeability of DNA origami based nuclear pore mimics. Feng Q, Saladin M, Wu C, Cao E, Zheng W, Zhang A, Bhardwaj P, Li X, Shen Q, Kapinos LE, Mariappan M, Lusk CP, Xiong Y, Lim RYH, Lin C. bioRxiv. 2024 May 12; 2024 May 12. PMID: 38766144.", + "Effect of loops on the mean-square displacement of Rouse-model chromatin. Yuan T, Yan H, Bailey MLP, Williams JF, Surovtsev I, King MC, Mochrie SGJ. Phys Rev E. 2024 Apr. PMID: 38755928.", + "It is time to reconsider the culture of volunteerism in undergraduate research. King MC. J Cell Sci. 2023 Dec 15; 2023 Dec 30. PMID: 38158844.", + "Dynamic regulation of LINC complex composition and function across tissues and contexts. King MC. FEBS Lett. 2023 Nov; 2023 Oct 24. PMID: 37846646.", + "Changing the guard-nuclear pore complex quality control. Veldsink AC, Gallardo P, Lusk CP, Veenhoff LM. FEBS Lett. 2023 Nov; 2023 Sep 24. PMID: 37715940.", + "An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity. Ader NR, Chen L, Surovtsev IV, Chadwick WL, Rodriguez EC, King MC, Lusk CP. Nat Cell Biol. 2023 Oct; 2023 Oct 2. PMID: 37783794.", + "Acetyl-methyllysine marks chromatin at active transcription start sites. Lu-Culligan WJ, Connor LJ, Xie Y, Ekundayo BE, Rose BT, Machyna M, Pintado-Urbanc AP, Zimmer JT, Vock IW, Bhanu NV, King MC, Garcia BA, Bleichert F, Simon MD. Nature. 2023 Oct; 2023 Sep 20. PMID: 37731000.", + "Loops and the activity of loop extrusion factors constrain chromatin dynamics. Bailey MLP, Surovtsev I, Williams JF, Yan H, Yuan T, Li K, Duseau K, Mochrie SGJ, King MC. Mol Biol Cell. 2023 Jul 1; 2023 Apr 26. PMID: 37126401.", + "Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels. Shen Q, Feng Q, Wu C, Xiong Q, Tian T, Yuan S, Shi J, Bedwell GJ, Yang R, Aiken C, Engelman AN, Lusk CP, Lin C, Xiong Y. Nat Struct Mol Biol. 2023 Apr; 2023 Feb 20. PMID: 36807645.", + "The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores. Shen Q, Kumari S, Xu C, Jang S, Shi J, Burdick RC, Levintov L, Xiong Q, Wu C, Devarkar SC, Tian T, Tripler TN, Hu Y, Yuan S, Temple J, Feng Q, Lusk CP, Aiken C, Engelman AN, Perilla JR, Pathak VK, Lin C, Xiong Y. Proc Natl Acad Sci U S A. 2023 Mar 28; 2023 Mar 21. PMID: 36943880.", + "Functionalized DNA-Origami-Protein Nanopores Generate Large Transmembrane Channels with Programmable Size-Selectivity. Shen Q, Xiong Q, Zhou K, Feng Q, Liu L, Tian T, Wu C, Xiong Y, Melia TJ, Lusk CP, Lin C. J Am Chem Soc. 2023 Jan 18; 2022 Dec 28. PMID: 36577119.", + "Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling. Hwang WY, Kostiuk V, González DP, Lusk CP, Khokha MK. Elife. 2022 Oct 27; 2022 Oct 27. PMID: 36300792.", + "Integrating mechanical signals into cellular identity. Carley E, King MC, Guo S. Trends Cell Biol. 2022 Aug; 2022 Mar 23. PMID: 35337714.", + "Homology-directed repair involves multiple strand invasion cycles in fission yeast. Vines AJ, Cox K, Leland BA, King MC. Mol Biol Cell. 2022 Apr 1; 2022 Jan 26. PMID: 35080989.", + "Emerging Connections between Nuclear Pore Complex Homeostasis and ALS. Chandra S, Lusk CP. Int J Mol Sci. 2022 Jan 25; 2022 Jan 25. PMID: 35163252.", + "One ring doesn't rule them all: Distinct nuclear pore complexes in a single cell. McCarthy MR, Lusk CP. Cell. 2022 Jan 20. PMID: 35063070.", + "Nuclear pore complexes feel the strain. Lusk CP, King MC. Mol Cell. 2021 Dec 16. PMID: 34919818.", + "Atg39 selectively captures inner nuclear membrane into lumenal vesicles for delivery to the autophagosome. Chandra S, Mannino PJ, Thaller DJ, Ader NR, King MC, Melia TJ, Lusk CP. J Cell Biol. 2021 Dec 6; 2021 Oct 29. PMID: 34714326.", + "Nuclear detox of unsaturated fat. Mannino PJ, Lusk CP. Dev Cell. 2021 Sep 27. PMID: 34582769.", + "Adaptation and validation of a computerized neurocognitive battery in the Xhosa of South Africa. Scott JC, Moore TM, Stein DJ, Pretorius A, Zingela Z, Nagdee M, Ngqengelele L, Campbell M, Sibeko G, King MC, McClellan JM, Port AM, Jackson C, Ruparel K, Susser ES, Gur RC. Neuropsychology. 2021 Sep; 2021 Jul 5. PMID: 34242045.", + "DNA-Origami NanoTrap for Studying the Selective Barriers Formed by Phenylalanine-Glycine-Rich Nucleoporins. Shen Q, Tian T, Xiong Q, Ellis Fisher PD, Xiong Y, Melia TJ, Lusk CP, Lin C. J Am Chem Soc. 2021 Aug 11; 2021 Jul 29. PMID: 34324340.", + "Extrusion of chromatin loops by a composite loop extrusion factor. Yan H, Surovtsev I, Williams JF, Bailey MLP, King MC, Mochrie SGJ. Phys Rev E. 2021 Aug. PMID: 34525654.", + "Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS. Coyne AN, Baskerville V, Zaepfel BL, Dickson DW, Rigo F, Bennett F, Lusk CP, Rothstein JD. Sci Transl Med. 2021 Jul 28. PMID: 34321318.", + "Heh2/Man1 may be an evolutionarily conserved sensor of NPC assembly state. Borah S, Thaller DJ, Hakhverdyan Z, Rodriguez EC, Isenhour AW, Rout MP, King MC, Lusk CP. Mol Biol Cell. 2021 Jul 15; 2021 May 19. PMID: 34010011.", + "The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation. Carley E, Stewart RM, Zieman A, Jalilian I, King DE, Zubek A, Lin S, Horsley V, King MC. Elife. 2021 Mar 29; 2021 Mar 29. PMID: 33779546.", + "Covariance distributions in single particle tracking. Bailey MLP, Yan H, Surovtsev I, Williams JF, King MC, Mochrie SGJ. Phys Rev E. 2021 Mar. PMID: 33862686.", + "Direct binding of ESCRT protein Chm7 to phosphatidic acid-rich membranes at nuclear envelope herniations. Thaller DJ, Tong D, Marklew CJ, Ader NR, Mannino PJ, Borah S, King MC, Ciani B, Lusk CP. J Cell Biol. 2021 Mar 1. PMID: 33464310.", + "Nucleoporin NUP205 plays a critical role in cilia and congenital disease. Marquez J, Bhattacharya D, Lusk CP, Khokha MK. Dev Biol. 2021 Jan 1; 2020 Oct 13. PMID: 33065118.", + "Telomere biology disorder prevalence and phenotypes in adults with familial hematologic and/or pulmonary presentations. Feurstein S, Adegunsoye A, Mojsilovic D, Vij R, West DePersia AH, Rajagopal PS, Osman A, Collins RH, Kim RH, Gore SD, Greenberg P, Godley LA, Li Z, Del Gaudio D, Subramanian HP, Das S, Walsh T, Gulsuner S, Segal JP, Husain AN, Gurbuxani S, King MC, Strek ME, Churpek JE. Blood Adv. 2020 Oct 13. PMID: 33035329.", + "A physicochemical perspective of aging from single-cell analysis of pH, macromolecular and organellar crowding in yeast. Mouton SN, Thaller DJ, Crane MM, Rempel IL, Terpstra OT, Steen A, Kaeberlein M, Lusk CP, Boersma AJ, Veenhoff LM. Elife. 2020 Sep 29; 2020 Sep 29. PMID: 32990592.", + "Going nuclear: Recent developments, cutting-edge tools, and new paradigms. Belmont AS, King MC. Curr Opin Cell Biol. 2020 Jun. PMID: 32682519.", + "Oncometabolites suppress DNA repair by disrupting local chromatin signalling. Sulkowski PL, Oeck S, Dow J, Economos NG, Mirfakhraie L, Liu Y, Noronha K, Bao X, Li J, Shuch BM, King MC, Bindra RS, Glazer PM. Nature. 2020 Jun; 2020 Jun 3. PMID: 32494005.", + "Torsin ATPase deficiency leads to defects in nuclear pore biogenesis and sequestration of MLF2. Rampello AJ, Laudermilch E, Vishnoi N, Prophet SM, Shao L, Zhao C, Lusk CP, Schlieker C. J Cell Biol. 2020 Jun 1. PMID: 32342107.", + "CHMPions of repair: Emerging perspectives on sensing and repairing the nuclear envelope barrier. Lusk CP, Ader NR. Curr Opin Cell Biol. 2020 Jun; 2020 Feb 24. PMID: 32105978.", + "Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes. Li P, Lees JA, Lusk CP, Reinisch KM. J Cell Biol. 2020 May 4. PMID: 32182622.", + "Differential turnover of Nup188 controls its levels at centrosomes and role in centriole duplication. Vishnoi N, Dhanasekeran K, Chalfant M, Surovstev I, Khokha MK, Lusk CP. J Cell Biol. 2020 Mar 2. PMID: 32211895.", + "Genetics of schizophrenia in the South African Xhosa. Gulsuner S, Stein DJ, Susser ES, Sibeko G, Pretorius A, Walsh T, Majara L, Mndini MM, Mqulwana SG, Ntola OA, Casadei S, Ngqengelele LL, Korchina V, van der Merwe C, Malan M, Fader KM, Feng M, Willoughby E, Muzny D, Baldinger A, Andrews HF, Gur RC, Gibbs RA, Zingela Z, Nagdee M, Ramesar RS, King MC, McClellan JM. Science. 2020 Jan 31. PMID: 32001654.", + "Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells. Hwang S, Williams JF, Kneissig M, Lioudyno M, Rivera I, Helguera P, Busciglio J, Storchova Z, King MC, Torres EM. Cell Rep. 2019 Nov 19. PMID: 31747614.", + "RNA-DNA Hybrids Support Recombination-Based Telomere Maintenance in Fission Yeast. Hu Y, Bennett HW, Liu N, Moravec M, Williams JF, Azzalin CM, King MC. Genetics. 2019 Oct; 2019 Aug 12. PMID: 31405990.", + "Quantification of Biomolecular Dynamics Inside Real and Synthetic Nuclear Pore Complexes Using Time-Resolved Atomic Force Microscopy. Stanley GJ, Akpinar B, Shen Q, Fisher PDE, Lusk CP, Lin C, Hoogenboom BW. ACS Nano. 2019 Jul 23; 2019 Jul 1. PMID: 31241896.", + "Loss of nuclear envelope integrity? No probLEM-BAF has it covered. King MC, Lusk CP. J Cell Biol. 2019 Jul 1; 2019 Jun 14. PMID: 31201264.", + "Ablation of SUN2-containing LINC complexes drives cardiac hypertrophy without interstitial fibrosis. Stewart RM, Rodriguez EC, King MC. Mol Biol Cell. 2019 Jul 1; 2019 May 15. PMID: 31091167.", + "Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics. Rempel IL, Crane MM, Thaller DJ, Mishra A, Jansen DP, Janssens G, Popken P, Akşit A, Kaeberlein M, van der Giessen E, Steen A, Onck PR, Lusk CP, Veenhoff LM. Elife. 2019 Jun 3; 2019 Jun 3. PMID: 31157618.", + "MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation. Hu X, Liu ZZ, Chen X, Schulz VP, Kumar A, Hartman AA, Weinstein J, Johnston JF, Rodriguez EC, Eastman AE, Cheng J, Min L, Zhong M, Carroll C, Gallagher PG, Lu J, Schwartz M, King MC, Krause DS, Guo S. Nat Commun. 2019 Apr 12; 2019 Apr 12. PMID: 30979898.", + "An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system. Thaller DJ, Allegretti M, Borah S, Ronchi P, Beck M, Lusk CP. Elife. 2019 Apr 3; 2019 Apr 3. PMID: 30942170.", + "A versatile image analysis platform for three-dimensional nuclear reconstruction. Williams JF, Mochrie SGJ, King MC. Methods. 2019 Mar 15; 2018 Oct 22. PMID: 30359725.", + "Intensive Surveillance with Biannual Dynamic Contrast-Enhanced Magnetic Resonance Imaging Downstages Breast Cancer in BRCA1 Mutation Carriers. Guindalini RSC, Zheng Y, Abe H, Whitaker K, Yoshimatsu TF, Walsh T, Schacht D, Kulkarni K, Sheth D, Verp MS, Bradbury AR, Churpek J, Obeid E, Mueller J, Khramtsova G, Liu F, Raoul A, Cao H, Romero IL, Hong S, Livingston R, Jaskowiak N, Wang X, Debiasi M, Pritchard CC, King MC, Karczmar G, Newstead GM, Huo D, Olopade OI. Clin Cancer Res. 2019 Mar 15; 2018 Aug 28. PMID: 30154229.", + "Expression of TorsinA in a heterologous yeast system reveals interactions with lumenal domains of LINC and nuclear pore complex components. Chalfant M, Barber KW, Borah S, Thaller D, Lusk CP. Mol Biol Cell. 2019 Mar 1; 2019 Jan 9. PMID: 30625036.", + "Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways. Klein HL, Bačinskaja G, Che J, Cheblal A, Elango R, Epshtein A, Fitzgerald DM, Gómez-González B, Khan SR, Kumar S, Leland BA, Marie L, Mei Q, Miné-Hattab J, Piotrowska A, Polleys EJ, Putnam CD, Radchenko EA, Saada AA, Sakofsky CJ, Shim EY, Stracy M, Xia J, Yan Z, Yin Y, Aguilera A, Argueso JL, Freudenreich CH, Gasser SM, Gordenin DA, Haber JE, Ira G, Jinks-Robertson S, King MC, Kolodner RD, Kuzminov A, Lambert SA, Lee SE, Miller KM, Mirkin SM, Petes TD, Rosenberg SM, Rothstein R, Symington LS, Zawadzki P, Kim N, Lisby M, Malkova A. Microb Cell. 2019 Jan 7; 2019 Jan 7. PMID: 30652105.", + "Rotten to the Core: Why Micronuclei Rupture. Lusk CP, King MC. Dev Cell. 2018 Nov 5. PMID: 30399332.", + "Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome. Braun DA, Lovric S, Schapiro D, Schneider R, Marquez J, Asif M, Hussain MS, Daga A, Widmeier E, Rao J, Ashraf S, Tan W, Lusk CP, Kolb A, Jobst-Schwan T, Schmidt JM, Hoogstraten CA, Eddy K, Kitzler TM, Shril S, Moawia A, Schrage K, Khayyat AIA, Lawson JA, Gee HY, Warejko JK, Hermle T, Majmundar AJ, Hugo H, Budde B, Motameny S, Altmüller J, Noegel AA, Fathy HM, Gale DP, Waseem SS, Khan A, Kerecuk L, Hashmi S, Mohebbi N, Ettenger R, Serdaroğlu E, Alhasan KA, Hashem M, Goncalves S, Ariceta G, Ubetagoyena M, Antonin W, Baig SM, Alkuraya FS, Shen Q, Xu H, Antignac C, Lifton RP, Mane S, Nürnberg P, Khokha MK, Hildebrandt F. J Clin Invest. 2018 Oct 1; 2018 Sep 4. PMID: 30179222.", + "Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks. Leland BA, Chen AC, Zhao AY, Wharton RC, King MC. Elife. 2018 Apr 26; 2018 Apr 26. PMID: 29697047.", + "A Programmable DNA Origami Platform for Organizing Intrinsically Disordered Nucleoporins within Nanopore Confinement. Fisher PDE, Shen Q, Akpinar B, Davis LK, Chung KKH, Baddeley D, Šarić A, Melia TJ, Hoogenboom BW, Lin C, Lusk CP. ACS Nano. 2018 Feb 27; 2018 Jan 25. PMID: 29350911.", + "Mutations in Homologous Recombination Genes and Outcomes in Ovarian Carcinoma Patients in GOG 218: An NRG Oncology/Gynecologic Oncology Group Study. Norquist BM, Brady MF, Harrell MI, Walsh T, Lee MK, Gulsuner S, Bernards SS, Casadei S, Burger RA, Tewari KS, Backes F, Mannel RS, Glaser G, Bailey C, Rubin S, Soper J, Lankes HA, Ramirez NC, King MC, Birrer MJ, Swisher EM. Clin Cancer Res. 2018 Feb 15; 2017 Nov 30. PMID: 29191972.", + "Multiplexed fluctuation-dissipation-theorem calibration of optical tweezers inside living cells. Yan H, Johnston JF, Cahn SB, King MC, Mochrie SGJ. Rev Sci Instrum. 2017 Nov. PMID: 29195389.", + "Not just Salk. Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M, Brugge J, Cech T, Colwell R, Craig N, deLange T, Eisen M, Gottesman S, Green R, Handelsman J, Kimble J, King MC, Lehmann R, Marder E, Mullins D, O'Shea E, Schmid S, Seydoux G, Spradling A, Storz G, Szostak J, Telesnitsky A, Tilghman S, Tjian R, Vale R, Wolberger C, Zakian V. Science. 2017 Sep 15. PMID: 28912235.", + "The nucleus: keeping it together by keeping it apart. Lusk CP, King MC. Curr Opin Cell Biol. 2017 Feb; 2017 Feb 23. PMID: 28236735.", + "TeloPCR-seq: a high-throughput sequencing approach for telomeres. Bennett HW, Liu N, Hu Y, King MC. FEBS Lett. 2016 Dec; 2016 Oct 21. PMID: 27714790.", + "Chm7 and Heh1 collaborate to link nuclear pore complex quality control with nuclear envelope sealing. Webster BM, Thaller DJ, Jäger J, Ochmann SE, Borah S, Lusk CP. EMBO J. 2016 Nov 15; 2016 Oct 12. PMID: 27733427.", + "Congenital Heart Disease Genetics Uncovers Context-Dependent Organization and Function of Nucleoporins at Cilia. Del Viso F, Huang F, Myers J, Chalfant M, Zhang Y, Reza N, Bewersdorf J, Lusk CP, Khokha MK. Dev Cell. 2016 Sep 12; 2016 Sep 1. PMID: 27593162.", + "Ultra-High Resolution 3D Imaging of Whole Cells. Huang F, Sirinakis G, Allgeyer ES, Schroeder LK, Duim WC, Kromann EB, Phan T, Rivera-Molina FE, Myers JR, Irnov I, Lessard M, Zhang Y, Handel MA, Jacobs-Wagner C, Lusk CP, Rothman JE, Toomre D, Booth MJ, Bewersdorf J. Cell. 2016 Aug 11; 2016 Jul 7. PMID: 27397506.", + "A model for coordinating nuclear mechanics and membrane remodeling to support nuclear integrity. King MC, Lusk CP. Curr Opin Cell Biol. 2016 Aug; 2016 Mar 28. PMID: 27031045.", + "Baby Nuclear Pores Grow Up Faster All the Time. Lusk CP. Cell. 2016 Jul 28. PMID: 27471962.", + "Improved Determination of Subnuclear Position Enabled by Three-Dimensional Membrane Reconstruction. Zhao Y, Schreiner SM, Koo PK, Colombi P, King MC, Mochrie SG. Biophys J. 2016 Jul 12. PMID: 27410730.", + "TERRA promotes telomerase-mediated telomere elongation in Schizosaccharomyces pombe. Moravec M, Wischnewski H, Bah A, Hu Y, Liu N, Lafranchi L, King MC, Azzalin CM. EMBO Rep. 2016 Jul; 2016 May 6. PMID: 27154402.", + "MYO3A Causes Human Dominant Deafness and Interacts with Protocadherin 15-CD2 Isoform. Grati M, Yan D, Raval MH, Walsh T, Ma Q, Chakchouk I, Kannan-Sundhari A, Mittal R, Masmoudi S, Blanton SH, Tekin M, King MC, Yengo CM, Liu XZ. Hum Mutat. 2016 May; 2016 Feb 16. PMID: 26841241.", + "Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication. Lahaye X, Satoh T, Gentili M, Cerboni S, Silvin A, Conrad C, Ahmed-Belkacem A, Rodriguez EC, Guichou JF, Bosquet N, Piel M, Le Grand R, King MC, Pawlotsky JM, Manel N. Cell Rep. 2016 Apr 26; 2016 Apr 14. PMID: 27149839.", + "Inherited Mutations in Women With Ovarian Carcinoma. Norquist BM, Harrell MI, Brady MF, Walsh T, Lee MK, Gulsuner S, Bernards SS, Casadei S, Yi Q, Burger RA, Chan JK, Davidson SA, Mannel RS, DiSilvestro PA, Lankes HA, Ramirez NC, King MC, Swisher EM, Birrer MJ. JAMA Oncol. 2016 Apr. PMID: 26720728.", + "Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments. Thiam HR, Vargas P, Carpi N, Crespo CL, Raab M, Terriac E, King MC, Jacobelli J, Alberts AS, Stradal T, Lennon-Dumenil AM, Piel M. Nat Commun. 2016 Mar 15; 2016 Mar 15. PMID: 26975831.", + "Border Safety: Quality Control at the Nuclear Envelope. Webster BM, Lusk CP. Trends Cell Biol. 2016 Jan; 2015 Oct 1. PMID: 26437591.", + "Forces, fluctuations, and self-organization in the nucleus. Pederson T, King MC, Marko JF. Mol Biol Cell. 2015 Nov 5. PMID: 26543199.", + "The tethering of chromatin to the nuclear envelope supports nuclear mechanics. Schreiner SM, Koo PK, Zhao Y, Mochrie SG, King MC. Nat Commun. 2015 Jun 15; 2015 Jun 15. PMID: 26074052.", + "Nuclear-cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions. Stewart RM, Zubek AE, Rosowski KA, Schreiner SM, Horsley V, King MC. J Cell Biol. 2015 May 11. PMID: 25963820.", + "ESCRTs breach the nuclear border. Webster BM, Lusk CP. Nucleus. 2015; 2015 May 5. PMID: 25942571.", + "Macromolecular transport between the nucleus and the cytoplasm: Advances in mechanism and emerging links to disease. Tran EJ, King MC, Corbett AH. Biochim Biophys Acta. 2014 Nov; 2014 Aug 9. PMID: 25116306.", + "Surveillance of nuclear pore complex assembly by ESCRT-III/Vps4. Webster BM, Colombi P, Jäger J, Lusk CP. Cell. 2014 Oct 9. PMID: 25303532.", + "The KASH protein Kms2 coordinates mitotic remodeling of the spindle pole body. Wälde S, King MC. J Cell Sci. 2014 Aug 15; 2014 Jun 24. PMID: 24963130.", + "A role for nuclear envelope-bridging complexes in homology-directed repair. Swartz RK, Rodriguez EC, King MC. Mol Biol Cell. 2014 Aug 15; 2014 Jun 18. PMID: 24943839.", + "Toward a consensus on the mechanism of nuclear pore complex inheritance. Lusk CP, Colombi P. Nucleus. 2014 Mar-Apr; 2014 Feb 25. PMID: 24637838.", + "Organization, stability, and expression of the genome. King MC. Mol Biol Cell. 2014 Mar. PMID: 24626848.", + "Using LacO arrays to monitor DNA double-strand break dynamics in live Schizosaccharomyces pombe cells. Leland BA, King MC. Methods Mol Biol. 2014. PMID: 25030924.", + "A quality control mechanism linking meiotic success to release of ascospores. Guo H, King MC. PLoS One. 2013; 2013 Dec 2. PMID: 24312672.", + "The transmission of nuclear pore complexes to daughter cells requires a cytoplasmic pool of Nsp1. Colombi P, Webster BM, Fröhlich F, Lusk CP. J Cell Biol. 2013 Oct 28. PMID: 24165936.", + "Maps & Directions", + "Calendar", + "Contact Us", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Ma Lab", + "lab_url": "https://medicine.yale.edu/lab/ma/", + "research_bio": "INFORMATION FOR Shuangge (Steven) Ma is an Associate Professor of Biostatistics at the Yale School of Public Health. Dr. Ma received his Ph.D. degree in statistics at University of Wisconsin in 2004. Prior to arriving at Yale, Dr. Ma was a Senior Fellow in Collaborative Health Studies Coordinating Center (CHSCC) and Department of Biostatistics at University of Washington. He has been involved in developing novel statistical and bioinformatics methodologies for analysis of cancer (NHL, breast cancer, melanoma, lung cancer), mental disorders, and cardiovascular diseases. He has also been involved in health economics research, with special interest in health insurance in developing countries. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/ma/publications/", + "publications": [ + "Yale School of Public Health /", + "Principal Investigator", + "Research", + "Publications", + "Contact", + "Prospective Students", + "Alumni", + "Donors", + "Employers", + "Academic Calendar", + "myYSPH Members", + "Support YSPH", + "Principal Investigator", + "Research", + "Publications", + "Contact", + "", + "", + "", + "", + "", + "", + "Robust sparse Bayesian regression for longitudinal gene-environment interactions. Fan K, Jiang Y, Ma S, Wang W, Wu C. J R Stat Soc Ser C Appl Stat. 2025 Dec; 2025 Apr 8. PMID: 41245172.", + "Ordinal Sparse Neural Networks for Modeling Gene- and Imaging-Environment Interactions. Xue J, Xu Y, Li J, Ma S, Fang K. Stat Med. 2025 Oct. PMID: 41105049.", + "Intranasal hemagglutinin protein boosters induce protective mucosal immunity against influenza A viruses in mice. Moriyama M, Rodrigues G, Wang J, Jayewickreme R, Hudak A, Dong H, Homer RJ, Ma S, Iwasaki A. Proc Natl Acad Sci U S A. 2025 Sep 30; 2025 Sep 24. PMID: 40991437.", + "Local Clustering for Functional Data. Chen Y, Zhang Q, Ma S. J Comput Graph Stat. 2025 Sep; 2025 Feb 10. PMID: 41200425.", + "NETWORK-BASED MODELING OF EMOTIONAL EXPRESSIONS FOR MULTIPLE CANCERS VIA A LINGUISTIC ANALYSIS OF AN ONLINE HEALTH COMMUNITY. Fan X, Liu M, Ma S. Ann Appl Stat. 2025 Sep; 2025 Aug 28. PMID: 41104371.", + "GE-IA-NAM: gene-environment interaction analysis via imaging-assisted neural additive model. Li J, Xu Y, Ma S, Fang K. Bioinformatics. 2025 Sep 1. PMID: 40880282.", + "Joint modeling of mixed outcomes using a rank-based sparse neural network. Xue J, Xu Y, Li J, Ma S, Fang K. J Biomed Inform. 2025 Sep; 2025 Jul 5. PMID: 40623577.", + "Subgroup Testing in the Change-Plane Cox Model. Zhang X, Ren P, Shi X, Ma S, Liu X. Stat Med. 2025 Jul. PMID: 40662752.", + "Robust Transfer Learning for High-Dimensional GLM Using γ -Divergence With Applications to Cancer Genomics. Xu F, Ma S, Zhang Q, Xu Y. Stat Med. 2025 Jul. PMID: 40662636.", + "Adoption of Broad Genomic Profiling in Patients With Cancer. Wang X, Rothen J, Huang S, Long JB, Soulos PR, Goldberg SB, Mamtani R, Presley CJ, Kunst N, Ma S, Wang SY, Gross CP, Dinan MA. JAMA Oncol. 2025 Jun 1. PMID: 40244595.", + "BPI25-017: A Novel Integrated Classification Schema for Molecular Findings by Potential Clinical Actionability: A Tool for Assessment of Real-World Cancer Care in the Targeted Therapy Era. Wang X, Long JB, Rothen J, Soulos PR, Robinson TJ, Presley CJ, Goldberg SB, Mamtani R, Wang SY, Kunst N, Ma S, Huang S, Gross CP, Dinan MA. J Natl Compr Canc Netw. 2025 Mar 28; 2025 Mar 28. PMID: 40154428.", + "High-Dimensional Gene-Environment Interaction Analysis. Wu M, Li Y, Ma S. Annu Rev Stat Appl. 2025 Mar; 2024 Sep 11. PMID: 40881670.", + "Hierarchical Multi-Label Classification With Gene-Environment Interactions in Disease Modeling. Li J, Zhang Q, Ma S, Fang K, Xu Y. Stat Med. 2025 Feb 10. PMID: 39865593.", + "Bayesian Modeling of Cancer Outcomes Using Genetic Variables Assisted by Pathological Imaging Data. Im Y, Li R, Ma S. Stat Med. 2025 Feb 10. PMID: 39840672.", + "Integrative rank-based regression for multi-source high-dimensional data with multi-type responses. Xu F, Ma S, Zhang Q. J Appl Stat. 2025; 2025 Jan 16. PMID: 40904949.", + "A Selective Review of Network Analysis Methods for Gene Expression Data. Li R, Yi H, Ma S. Methods Mol Biol. 2025. PMID: 39900765.", + "Incorporating prior information in gene expression network-based cancer heterogeneity analysis. Li R, Xu S, Li Y, Tang Z, Feng D, Cai J, Ma S. Biostatistics. 2024 Dec 31. PMID: 39074174.", + "Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors. Kwan JM, Shen M, Akhlaghi N, Hu JR, Mora R, Cross JL, Jiang M, Mankbadi M, Wang P, Zaman S, Lee S, Im Y, Feher A, Liu YH, Ma SS, Tao W, Wei W, Baldassarre LA. PLoS One. 2024; 2024 Dec 2. PMID: 39621799.", + "The spike-and-slab quantile LASSO for robust variable selection in cancer genomics studies. Liu Y, Ren J, Ma S, Wu C. Stat Med. 2024 Nov 20; 2024 Sep 11. PMID: 39260448.", + "CTHRC1(+) fibroblasts and SPP1(+) macrophages synergistically contribute to pro-tumorigenic tumor microenvironment in pancreatic ductal adenocarcinoma. Li E, Cheung HCZ, Ma S. Sci Rep. 2024 Jul 29; 2024 Jul 29. PMID: 39075108.", + "Editorial. Ma S. Brief Bioinform. 2024 Jul 25. PMID: 39288229.", + "HEARTSVG: a fast and accurate method for identifying spatially variable genes in large-scale spatial transcriptomics. Yuan X, Ma Y, Gao R, Cui S, Wang Y, Fa B, Ma S, Wei T, Ma S, Yu Z. Nat Commun. 2024 Jul 7; 2024 Jul 7. PMID: 38972896.", + "Estimation of multiple networks with common structures in heterogeneous subgroups. Qin X, Hu J, Ma S, Wu M. J Multivar Anal. 2024 Jul; 2024 Feb 13. PMID: 38433779.", + "Partial Hepatectomy and Ablation for Survival of Early-Stage Hepatocellular Carcinoma Patients: A Bayesian Emulation Analysis. Wang J, Im Y, Wang R, Ma S. Life (Basel). 2024 May 22; 2024 May 22. PMID: 38929645.", + "Information-incorporated sparse hierarchical cancer heterogeneity analysis. Han W, Zhang S, Ma S, Ren M. Stat Med. 2024 May 20; 2024 Mar 30. PMID: 38553996.", + "Endocrine disrupting chemical mixture exposure and risk of papillary thyroid cancer in U.S. military personnel: A nested case-control study. Denic-Roberts H, McAdam J, Sjodin A, Davis M, Jones R, Ward MH, Hoang TD, Ma S, Zhang Y, Rusiecki JA. Sci Total Environ. 2024 Apr 20; 2024 Feb 28. PMID: 38428594.", + "Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches. Yang BZ, Xiang B, Wang T, Ma S, Li CR. Psychiatry Res. 2024 Apr; 2024 Feb 28. PMID: 38422867.", + "Hierarchical False Discovery Rate Control for High-dimensional Survival Analysis with Interactions. Liang W, Zhang Q, Ma S. Comput Stat Data Anal. 2024 Apr; 2023 Dec 5. PMID: 38098875.", + "Prediction Consistency Regularization for Learning with Noise Labels Based on Contrastive Clustering. Sun X, Zhang S, Ma S. Entropy (Basel). 2024 Mar 30; 2024 Mar 30. PMID: 38667864.", + "Organochlorine pesticides and risk of papillary thyroid cancer in U.S. military personnel: a nested case-control study. Rusiecki JA, McAdam J, Denic-Roberts H, Sjodin A, Davis M, Jones R, Hoang TD, Ward MH, Ma S, Zhang Y. Environ Health. 2024 Mar 19; 2024 Mar 19. PMID: 38504322.", + "A QUANTITATIVE LINGUISTIC ANALYSIS OF A CANCER ONLINE HEALTH COMMUNITY WITH A SMOOTH LATENT SPACE MODEL. Liu M, Fan X, Ma S. Ann Appl Stat. 2024 Mar; 2024 Jan 31. PMID: 40881042.", + "Gene-environment interaction analysis under the Cox model. Fang K, Li J, Xu Y, Ma S, Zhang Q. Ann Inst Stat Math. 2023 Dec; 2023 Apr 10. PMID: 39990259.", + "FunctanSNP: an R package for functional analysis of dense SNP data (with interactions). Ren R, Fang K, Zhang Q, Ma S. Bioinformatics. 2023 Dec 1. PMID: 38060266.", + "Pathological imaging-assisted cancer gene-environment interaction analysis. Fang K, Li J, Zhang Q, Xu Y, Ma S. Biometrics. 2023 Dec; 2023 May 17. PMID: 37132273.", + "Bi-level structured functional analysis for genome-wide association studies. Wu M, Wang F, Ge Y, Ma S, Li Y. Biometrics. 2023 Dec; 2023 May 7. PMID: 37098961.", + "The Bayesian Regularized Quantile Varying Coefficient Model. Zhou F, Ren J, Ma S, Wu C. Comput Stat Data Anal. 2023 Nov; 2023 Jun 23. PMID: 38746689.", + "Locally sparse quantile estimation for a partially functional interaction model. Liang W, Zhang Q, Ma S. Comput Stat Data Anal. 2023 Oct; 2023 May 25. PMID: 39555004.", + "Comparative Effectiveness Analysis of Lumpectomy and Mastectomy for Elderly Female Breast Cancer Patients: A Deep Learning-based Big Data Analysis. Wang J, Zhang S, Yi H, Ma S. Yale J Biol Med. 2023 Sep; 2023 Sep 29. PMID: 37781001.", + "ZINBMM: a general mixture model for simultaneous clustering and gene selection using single-cell transcriptomic data. Li Y, Wu M, Ma S, Wu M. Genome Biol. 2023 Sep 11; 2023 Sep 11. PMID: 37697330.", + "Two-level Bayesian interaction analysis for survival data incorporating pathway information. Qin X, Ma S, Wu M. Biometrics. 2023 Sep; 2022 Dec 27. PMID: 36524727.", + "Prior information-assisted integrative analysis of multiple datasets. Wang F, Liang D, Li Y, Ma S. Bioinformatics. 2023 Aug 1. PMID: 37490475.", + "Aligned deep neural network for integrative analysis with high-dimensional input. Zhang S, Zhang S, Yi H, Ma S. J Biomed Inform. 2023 Aug; 2023 Jun 28. PMID: 37391115.", + "Robust Bayesian variable selection for gene-environment interactions. Ren J, Zhou F, Li X, Ma S, Jiang Y, Wu C. Biometrics. 2023 Jun; 2022 Apr 16. PMID: 35394058.", + "Bayesian finite mixture of regression analysis for cancer based on histopathological imaging-environment interactions. Im Y, Huang Y, Tan A, Ma S. Biostatistics. 2023 Apr 14. PMID: 37057611.", + "HETEROGENEITY ANALYSIS VIA INTEGRATING MULTI-SOURCES HIGH-DIMENSIONAL DATA WITH APPLICATIONS TO CANCER STUDIES. Zhong T, Zhang Q, Huang J, Wu M, Ma S. Stat Sin. 2023 Apr. PMID: 38037567.", + "Unified model-free interaction screening via CV-entropy filter. Xiong W, Chen Y, Ma S. Comput Stat Data Anal. 2023 Apr; 2022 Dec 28. PMID: 36910335.", + "Gene-environment interaction analysis via deep learning. Wu S, Xu Y, Zhang Q, Ma S. Genet Epidemiol. 2023 Apr; 2023 Feb 19. PMID: 36807383.", + "SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity. Jaycox JR, Lucas C, Yildirim I, Dai Y, Wang EY, Monteiro V, Lord S, Carlin J, Kita M, Buckner JH, Ma S, Campbell M, Ko A, Omer S, Lucas CL, Speake C, Iwasaki A, Ring AM. Nat Commun. 2023 Mar 9; 2023 Mar 9. PMID: 36894554.", + "Human disease clinical treatment network for the elderly: analysis of the medicare inpatient length of stay and readmission data. Mei H, Jia R, Qiao G, Lin Z, Ma S. Biometrics. 2023 Mar; 2021 Sep 16. PMID: 34411297.", + "Rank-Based Greedy Model Averaging for High-Dimensional Survival Data. He B, Ma S, Zhang X, Zhu LX. J Am Stat Assoc. 2023; 2022 Jul 7. PMID: 39552724.", + "A General Framework for Identifying Hierarchical Interactions and Its Application to Genomics Data. Xiao Z, Xingjie S, Yiming L, Xu L, Ma S. J Comput Graph Stat. 2023; 2023 Feb 6. PMID: 38009111.", + "Spatio-temporally smoothed deep survival neural network. Li Y, Liang D, Ma S, Ma C. J Biomed Inform. 2023 Jan; 2022 Dec 1. PMID: 36462600.", + "Hierarchical cancer heterogeneity analysis based on histopathological imaging features. Ren M, Zhang Q, Zhang S, Zhong T, Huang J, Ma S. Biometrics. 2022 Dec; 2021 Aug 22. PMID: 34390584.", + "Multidimensional molecular measurements-environment interaction analysis for disease outcomes. Xu Y, Wu M, Ma S. Biometrics. 2022 Dec; 2021 Aug 1. PMID: 34213006.", + "A high-efficiency differential expression method for cancer heterogeneity using large-scale single-cell RNA-sequencing data. Yuan X, Ma S, Fa B, Wei T, Ma Y, Wang Y, Lv W, Zhang Y, Zheng J, Chen G, Sun J, Yu Z. Front Genet. 2022; 2022 Nov 29. PMID: 36523772.", + "A Linguistic Analysis of News Coverage of E-Healthcare in China with a Heterogeneous Graphical Model. Liu M, Fan X, Ma S. Entropy (Basel). 2022 Oct 29; 2022 Oct 29. PMID: 36359647.", + "A tree-based gene-environment interaction analysis with rare features. Liu M, Zhang Q, Ma S. Stat Anal Data Min. 2022 Oct; 2022 Mar 1. PMID: 38046814.", + "Replicability in cancer omics data analysis: measures and empirical explorations. Wang J, Liang H, Zhang Q, Ma S. Brief Bioinform. 2022 Sep 20. PMID: 35876281.", + "Survival Analysis with High-Dimensional Omics Data Using a Threshold Gradient Descent Regularization-Based Neural Network Approach. Fan Y, Zhang S, Ma S. Genes (Basel). 2022 Sep 19; 2022 Sep 19. PMID: 36140842.", + "A nested case-control study of serum polychlorinated biphenyls and papillary thyroid cancer risk among U.S. military service members. Zhuo H, Huang H, Sjodin A, Jin L, Ma S, Denic-Roberts H, Warren JL, Jones R, Davis M, Sun P, Yu H, Ward MH, Udelsman R, Zhang Y, Rusiecki JA. Environ Res. 2022 Sep; 2022 May 2. PMID: 35504340.", + "HIV viral transcription and immune perturbations in the CNS of people with HIV despite ART. Farhadian SF, Lindenbaum O, Zhao J, Corley MJ, Im Y, Walsh H, Vecchio A, Garcia-Milian R, Chiarella J, Chintanaphol M, Calvi R, Wang G, Ndhlovu LC, Yoon J, Trotta D, Ma S, Kluger Y, Spudich S. JCI Insight. 2022 Jul 8; 2022 Jul 8. PMID: 35801589.", + "Sparse group variable selection for gene-environment interactions in the longitudinal study. Zhou F, Lu X, Ren J, Fan K, Ma S, Wu C. Genet Epidemiol. 2022 Jul; 2022 Jun 29. PMID: 35766061.", + "Changes in prostate cancer survival among insured patients in relation to USPSTF screening recommendations. Kim IE Jr, Kim DD, Kim S, Ma S, Jang TL, Singer EA, Ghodoussipour S, Kim IY. BMC Urol. 2022 Jun 25; 2022 Jun 25. PMID: 35752822.", + "Information-incorporated Gaussian graphical model for gene expression data. Yi H, Zhang Q, Lin C, Ma S. Biometrics. 2022 Jun; 2021 Feb 12. PMID: 33527365.", + "Gaussian graphical model-based heterogeneity analysis via penalized fusion. Ren M, Zhang S, Zhang Q, Ma S. Biometrics. 2022 Jun; 2021 Feb 5. PMID: 33501648.", + "GEInfo: an R package for gene-environment interaction analysis incorporating prior information. Wang X, Liu H, Ma S. Bioinformatics. 2022 May 26. PMID: 35485739.", + "iSFun: an R package for integrative dimension reduction analysis. Fang K, Ren R, Zhang Q, Ma S. Bioinformatics. 2022 May 26. PMID: 35441661.", + "No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination. Lu-Culligan A, Tabachnikova A, Pérez-Then E, Tokuyama M, Lee HJ, Lucas C, Silva Monteiro V, Miric M, Brache V, Cochon L, Muenker MC, Mohanty S, Huang J, Kang I, Dela Cruz C, Farhadian S, Campbell M, Yildirim I, Shaw AC, Ma S, Vermund SH, Ko AI, Omer SB, Iwasaki A. PLoS Biol. 2022 May; 2022 May 24. PMID: 35609110.", + "Network-based cancer heterogeneity analysis incorporating multi-view of prior information. Li Y, Xu S, Ma S, Wu M. Bioinformatics. 2022 May 13. PMID: 35561185.", + "Biclustering analysis of functionals via penalized fusion. Fang K, Chen Y, Ma S, Zhang Q. J Multivar Anal. 2022 May; 2021 Oct 29. PMID: 36817965.", + "Integrative functional linear model for genome-wide association studies with multiple traits. Li Y, Wang F, Wu M, Ma S. Biostatistics. 2022 Apr 13. PMID: 33040145.", + "Bayesian hierarchical finite mixture of regression for histopathological imaging-based cancer data analysis. Im Y, Huang Y, Huang J, Ma S. Stat Med. 2022 Mar 15; 2022 Jan 13. PMID: 35028949.", + "Analysis of cancer omics data: a selective review of statistical techniques. Ma C, Wu M, Ma S. Brief Bioinform. 2022 Mar 10. PMID: 35039832.", + "Gene-environment interaction identification via penalized robust divergence. Ren M, Zhang S, Ma S, Zhang Q. Biom J. 2022 Mar; 2021 Nov 1. PMID: 34725857.", + "Comparative Analysis of Social Support in Online Health Communities Using a Word Co-Occurrence Network Analysis Approach. Liu M, Zou X, Chen J, Ma S. Entropy (Basel). 2022 Jan 25; 2022 Jan 25. PMID: 35205469.", + "Default risk prediction and feature extraction using a penalized deep neural network. Lin C, Qiao N, Zhang W, Li Y, Ma S. Stat Comput. 2022; 2022 Sep 15. PMID: 36124203.", + "Gene-gene interaction analysis incorporating network information via a structured Bayesian approach. Qin X, Ma S, Wu M. Stat Med. 2021 Dec 20; 2021 Sep 20. PMID: 34542187.", + "Histopathological imaging-based cancer heterogeneity analysis via penalized fusion with model averaging. He B, Zhong T, Huang J, Liu Y, Zhang Q, Ma S. Biometrics. 2021 Dec; 2020 Aug 29. PMID: 32822084.", + "An emulated target trial analysis based on Medicare data suggested non-inferiority of Dabigatran versus Rivaroxaban. Mei H, Wang J, Ma S. J Clin Epidemiol. 2021 Nov; 2021 Jul 14. PMID: 34271110.", + "GEInter: an R package for robust gene-environment interaction analysis. Wu M, Qin X, Ma S. Bioinformatics. 2021 Oct 25. PMID: 33961050.", + "HeteroGGM: an R package for Gaussian graphical model-based heterogeneity analysis. Ren M, Zhang S, Zhang Q, Ma S. Bioinformatics. 2021 Sep 29. PMID: 33638346.", + "Assisted differential network analysis for gene expression data. Yi H, Ma S. Genet Epidemiol. 2021 Sep; 2021 Jun 26. PMID: 34174112.", + "Marginal false discovery rate for a penalized transformation survival model. Liang W, Ma S, Lin C. Comput Stat Data Anal. 2021 Aug; 2021 Apr 2. PMID: 34393307.", + "Biomarker-guided heterogeneity analysis of genetic regulations via multivariate sparse fusion. Zhang S, Hu X, Luo Z, Jiang Y, Sun Y, Ma S. Stat Med. 2021 Jul 30; 2021 Apr 27. PMID: 33906263.", + "DReSS: a method to quantitatively describe the influence of structural perturbations on state spaces of genetic regulatory networks. Yin Z, Guo B, Ma S, Sun Y, Mi Z, Zheng Z. Brief Bioinform. 2021 Jul 20. PMID: 33313791.", + "Kynurenic acid may underlie sex-specific immune responses to COVID-19. Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Yan H, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh JE, Silva J, Wong P, Ko AI, Khan SA, Iwasaki A, Johnson CH. Sci Signal. 2021 Jul 6; 2021 Jul 6. PMID: 34230210.", + "Diverse functional autoantibodies in patients with COVID-19. Wang EY, Mao T, Klein J, Dai Y, Huck JD, Jaycox JR, Liu F, Zhou T, Israelow B, Wong P, Coppi A, Lucas C, Silva J, Oh JE, Song E, Perotti ES, Zheng NS, Fischer S, Campbell M, Fournier JB, Wyllie AL, Vogels CBF, Ott IM, Kalinich CC, Petrone ME, Watkins AE, Dela Cruz C, Farhadian SF, Schulz WL, Ma S, Grubaugh ND, Ko AI, Iwasaki A, Ring AM. Nature. 2021 Jul; 2021 May 19. PMID: 34010947.", + "Assisted estimation of gene expression graphical models. Yi H, Zhang Q, Sun Y, Ma S. Genet Epidemiol. 2021 Jun; 2021 Feb 1. PMID: 33527531.", + "Vertical integration methods for gene expression data analysis. Wu M, Yi H, Ma S. Brief Bioinform. 2021 May 20. PMID: 32793970.", + "Human disease clinical treatment network for the elderly: The analysis of medicare inpatient length of stay data. Mei H, Jia R, Qiao G, Lin Z, Ma S. Stat Med. 2021 Apr 15; 2021 Feb 2. PMID: 33527492.", + "Integrative sparse partial least squares. Liang W, Ma S, Zhang Q, Zhu T. Stat Med. 2021 Apr; 2021 Feb 8. PMID: 33559203.", + "A likelihood ratio test on temporal trends in age-period-cohort models with applications to the disparities of heart disease mortality among US populations and comparison with Japan. Fu W, Ding J, Gao K, Ma S, Tian L. Stat Med. 2021 Feb 10; 2020 Nov 18. PMID: 33210329.", + "Differential immunomodulatory effect of PARP inhibition in BRCA1 deficient and competent tumor cells. Alvarado-Cruz I, Mahmoud M, Khan M, Zhao S, Oeck S, Meas R, Clairmont K, Quintana V, Zhu Y, Porciuncula A, Wyatt H, Ma S, Shyr Y, Kong Y, LoRusso PM, Laverty D, Nagel ZD, Schalper KA, Krauthammer M, Sweasy JB. Biochem Pharmacol. 2021 Feb; 2020 Dec 4. PMID: 33285109.", + "Saliva viral load is a dynamic unifying correlate of COVID-19 severity and mortality. Silva J, Lucas C, Sundaram M, Israelow B, Wong P, Klein J, Tokuyama M, Lu P, Venkataraman A, Liu F, Mao T, Oh JE, Park A, Casanovas-Massana A, Vogels CBF, Muenker MC, Zell J, Fournier JB, Campbell M, Chiorazzi M, Fuentes ER, Petrone ME, Kalinich CC, Ott IM, Watkins A, Moore AJ, Nakahata M, Farhadian S, Cruz CD, Ko AI, Schulz WL, Ring A, Ma S, Omer S, Wyllie AL, Iwasaki A. medRxiv. 2021 Jan 10; 2021 Jan 10. PMID: 33442706.", + "Integration of Proteomics and Other Omics Data. Wu M, Jiang Y, Ma S. Methods Mol Biol. 2021. PMID: 34236669.", + "Gene-Environment Interaction: A Variable Selection Perspective. Zhou F, Ren J, Lu X, Ma S, Wu C. Methods Mol Biol. 2021. PMID: 33733358.", + "Regional Adoption of Commercial Gene Expression Testing for Prostate Cancer. Leapman MS, Wang R, Ma S, Gross CP, Ma X. JAMA Oncol. 2021 Jan 1. PMID: 33237277.", + "Identification of Prognostic Genes and Pathways in Lung Adenocarcinoma Using a Bayesian Approach. Jiang Y, Huang Y, Du Y, Zhao Y, Ren J, Ma S, Wu C. Cancer Inform. 2017; 2020 Dec 10. PMID: 33354107.", + "Evaluation of Survival Outcomes of Endovascular Versus Open Aortic Repair for Abdominal Aortic Aneurysms with a Big Data Approach. Mei H, Xu Y, Wang J, Ma S. Entropy (Basel). 2020 Nov 30; 2020 Nov 30. PMID: 33265931.", + "Associations of physical activity and screen time with suboptimal health status and sleep quality among Chinese college freshmen: A cross-sectional study. Ma C, Zhou L, Xu W, Ma S, Wang Y. PLoS One. 2020; 2020 Sep 18. PMID: 32946516.", + "Calendar", + "PO Box 208034 New Haven, CT 06520-8034", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Madri Lab", + "lab_url": "https://medicine.yale.edu/lab/madri/", + "research_bio": "INFORMATION FOR Copy Link Current projects ongoing in the Madri laboratory: Read more about ourResearch Projects in the Madri Lab. Lectures from the Symposium in honor of Joseph A. Madri, Professor Emeritus of Pathology, Friday, April 28, 2017, Yale Medical School. Speakers: Jon S. Morrow, Laura R. Ment, Dita Gratzinger, Olivier N. Kocher, and Mina J. Bissell. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/madri/publications/", + "publications": [ + "Yale School of Medicine /", + "Pathology /", + "Research", + "News", + "People", + "Publications", + "Contact", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "Contact", + "News", + "", + "", + "", + "", + "", + "", + "CD31 as a probable responding and gate-keeping protein of the blood-brain barrier and the risk of Alzheimer's disease. Zhang Z, Gan Q, Han J, Tao Q, Qiu WQ, Madri JA. J Cereb Blood Flow Metab. 2023 Jul; 2023 Apr 12. PMID: 37051650.", + "A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells. Boisvert EM, Means RE, Michaud M, Thomson JJ, Madri JA, Katz SG. J Vis Exp. 2020 Mar 4; 2020 Mar 4. PMID: 32202516.", + "Somatic PRKAR1A mutation in sporadic atrial myxoma with cerebral parenchymal metastases: a case report. Roque A, Kimbrough T, Traner C, Baehring JM, Huttner A, Adams J, Canosa S, Sklar J, Madri JA. J Med Case Rep. 2019 Dec 25; 2019 Dec 25. PMID: 31874650.", + "Minocycline mitigates the effect of neonatal hypoxic insult on human brain organoids. Boisvert EM, Means RE, Michaud M, Madri JA, Katz SG. Cell Death Dis. 2019 Apr 11; 2019 Apr 11. PMID: 30975982.", + "MMP-2: A modulator of neuronal precursor activity and cognitive and motor behaviors. Li Q, Michaud M, Shankar R, Canosa S, Schwartz M, Madri JA. Behav Brain Res. 2017 Aug 30; 2017 Jun 27. PMID: 28666838.", + "As human lung microvascular endothelia achieve confluence, src family kinases are activated, and tyrosine-phosphorylated p120 catenin physically couples NEU1 sialidase to CD31. Hyun SW, Liu A, Liu Z, Lillehoj EP, Madri JA, Reynolds AB, Goldblum SE. Cell Signal. 2017 Jul; 2017 Mar 24. PMID: 28343945.", + "-NOD Mice Having a Lyn Tyrosine Kinase Mutation Exhibit Abnormal Neutrophil Chemotaxis. Wu Y, Hannigan M, Zhan L, Madri JA, Huang CK. J Cell Physiol. 2017 Jul; 2017 Mar 27. PMID: 27591397.", + "CD44 Promotes Inflammation and Extracellular Matrix Production During Arteriovenous Fistula Maturation. Kuwahara G, Hashimoto T, Tsuneki M, Yamamoto K, Assi R, Foster TR, Hanisch JJ, Bai H, Hu H, Protack CD, Hall MR, Schardt JS, Jay SM, Madri JA, Kodama S, Dardik A. Arterioscler Thromb Vasc Biol. 2017 Jun; 2017 Apr 27. PMID: 28450292.", + "Increased Oxidative Stress and Hypoxia Inducible Factor-1 Expression during Arteriovenous Fistula Maturation. Sadaghianloo N, Yamamoto K, Bai H, Tsuneki M, Protack CD, Hall MR, Declemy S, Hassen-Khodja R, Madri J, Dardik A. Ann Vasc Surg. 2017 May; 2017 Feb 3. PMID: 28163173.", + "The role of endothelial HIF-1 αin the response to sublethal hypoxia in C57BL/6 mouse pups. Li Q, Michaud M, Park C, Huang Y, Couture R, Girodano F, Schwartz ML, Madri JA. Lab Invest. 2017 Apr; 2017 Jan 16. PMID: 28092362.", + "Targeted proteomics effectively quantifies differences between native lung and detergent-decellularized lung extracellular matrices. Calle EA, Hill RC, Leiby KL, Le AV, Gard AL, Madri JA, Hansen KC, Niklason LE. Acta Biomater. 2016 Dec; 2016 Sep 29. PMID: 27693690.", + "CD44 Influences Fibroblast Behaviors Via Modulation of Cell-Cell and Cell-Matrix Interactions, Affecting Survivin and Hippo Pathways. Tsuneki M, Madri JA. J Cell Physiol. 2016 Mar. PMID: 26248063.", + "ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy. Albright RA, Stabach P, Cao W, Kavanagh D, Mullen I, Braddock AA, Covo MS, Tehan M, Yang G, Cheng Z, Bouchard K, Yu ZX, Thorn S, Wang X, Folta-Stogniew EJ, Negrete A, Sinusas AJ, Shiloach J, Zubal G, Madri JA, De La Cruz EM, Braddock DT. Nat Commun. 2015 Dec 1; 2015 Dec 1. PMID: 26624227.", + "Modulation of Sox10, HIF-1α, Survivin, and YAP by Minocycline in the Treatment of Neurodevelopmental Handicaps following Hypoxic Insult. Li Q, Tsuneki M, Krauthammer M, Couture R, Schwartz M, Madri JA. Am J Pathol. 2015 Sep; 2015 Jul 22. PMID: 26209807.", + "A hydrogel-endothelial cell implant mimics infantile hemangioma: modulation by survivin and the Hippo pathway. Tsuneki M, Hardee S, Michaud M, Morotti R, Lavik E, Madri JA. Lab Invest. 2015 Jul; 2015 May 11. PMID: 25961170.", + "Disturbed shear stress reduces Klf2 expression in arterial-venous fistulae in vivo. Yamamoto K, Protack CD, Kuwahara G, Tsuneki M, Hashimoto T, Hall MR, Assi R, Brownson KE, Foster TR, Bai H, Wang M, Madri JA, Dardik A. Physiol Rep. 2015 Mar. PMID: 25780089.", + "Temporal regulation of venous extracellular matrix components during arteriovenous fistula maturation. Hall MR, Yamamoto K, Protack CD, Tsuneki M, Kuwahara G, Assi R, Brownson KE, Bai H, Madri JA, Dardik A. J Vasc Access. 2015 Mar-Apr; 2014 Sep 8. PMID: 25262757.", + "Adhesion molecule-mediated hippo pathway modulates hemangioendothelioma cell behavior. Tsuneki M, Madri JA. Mol Cell Biol. 2014 Dec; 2014 Sep 29. PMID: 25266662.", + "Stratified control of IGF-I expression by hypoxia and stress hormones in osteoblasts. McCarthy TL, Yun Z, Madri JA, Centrella M. Gene. 2014 Apr 10; 2014 Jan 15. PMID: 24440782.", + "NEU1 sialidase regulates the sialylation state of CD31 and disrupts CD31-driven capillary-like tube formation in human lung microvascular endothelia. Lee C, Liu A, Miranda-Ribera A, Hyun SW, Lillehoj EP, Cross AS, Passaniti A, Grimm PR, Kim BY, Welling PA, Madri JA, DeLisser HM, Goldblum SE. J Biol Chem. 2014 Mar 28; 2014 Feb 18. PMID: 24550400.", + "CD44 regulation of endothelial cell proliferation and apoptosis via modulation of CD31 and VE-cadherin expression. Tsuneki M, Madri JA. J Biol Chem. 2014 Feb 28; 2014 Jan 14. PMID: 24425872.", + "The mouse aortocaval fistula recapitulates human arteriovenous fistula maturation. Yamamoto K, Protack CD, Tsuneki M, Hall MR, Wong DJ, Lu DY, Assi R, Williams WT, Sadaghianloo N, Bai H, Miyata T, Madri JA, Dardik A. Am J Physiol Heart Circ Physiol. 2013 Dec; 2013 Oct 4. PMID: 24097429.", + "Modeling the neurovascular niche: unbiased transcriptome analysis of the murine subventricular zone in response to hypoxic insult. Li Q, Canosa S, Flynn K, Michaud M, Krauthammer M, Madri JA. PLoS One. 2013; 2013 Oct 11. PMID: 24146847.", + "CD44 regulates vascular endothelial barrier integrity via a PECAM-1 dependent mechanism. Flynn KM, Michaud M, Canosa S, Madri JA. Angiogenesis. 2013 Jul; 2013 Mar 17. PMID: 23504212.", + "CD44 deficiency contributes to enhanced experimental autoimmune encephalomyelitis: a role in immune cells and vascular cells of the blood-brain barrier. Flynn KM, Michaud M, Madri JA. Am J Pathol. 2013 Apr; 2013 Feb 12. PMID: 23416161.", + "Brain regional angiogenic potential at the neurovascular unit during normal aging. Murugesan N, Demarest TG, Madri JA, Pachter JS. Neurobiol Aging. 2012 May; 2011 Oct 21. PMID: 22019053.", + "Phosphorus-31 MRI of hard and soft solids using quadratic echo line-narrowing. Frey MA, Michaud M, VanHouten JN, Insogna KL, Madri JA, Barrett SE. Proc Natl Acad Sci U S A. 2012 Apr 3; 2012 Mar 19. PMID: 22431609.", + "Short term interactions with long term consequences: modulation of chimeric vessels by neural progenitors. Williams C, Rauch MF, Michaud M, Robinson R, Xu H, Madri J, Lavik E. PLoS One. 2012; 2012 Dec 27. PMID: 23300890.", + "Characterization of the natural history of extracellular matrix production in tissue-engineered vascular grafts during neovessel formation. Naito Y, Williams-Fritze M, Duncan DR, Church SN, Hibino N, Madri JA, Humphrey JD, Shinoka T, Breuer CK. Cells Tissues Organs. 2012; 2011 Oct 12. PMID: 21996715.", + "A critical role for macrophages in neovessel formation and the development of stenosis in tissue-engineered vascular grafts. Hibino N, Yi T, Duncan DR, Rathore A, Dean E, Naito Y, Dardik A, Kyriakides T, Madri J, Pober JS, Shinoka T, Breuer CK. FASEB J. 2011 Dec; 2011 Aug 24. PMID: 21865316.", + "Cyclic strain delays the expression of tissue factor induced by thrombin in human umbilical vein endothelial cells. Yamashita N, Abe R, Nixon AM, Rochier AL, Madri JA, Sumpio BE. Int J Angiol. 2011 Sep. PMID: 22942631.", + "Varying effects of hemodynamic forces on tissue factor RNA expression in human endothelial cells. Abe R, Yamashita N, Rochier A, Nixon A, Abe R, Madri JA, Sumpio BE. J Surg Res. 2011 Sep; 2011 May 4. PMID: 21592524.", + "Laminar shear, but not orbital shear, has a synergistic effect with thrombin stimulation on tissue factor expression in human umbilical vein endothelial cells. Rochier A, Nixon A, Yamashita N, Abe R, Abe R, Madri JA, Sumpio BE. J Vasc Surg. 2011 Aug; 2011 Mar 2. PMID: 21367569.", + "GSK-3β: a signaling pathway node modulating neural stem cell and endothelial cell interactions. Li Q, Michaud M, Canosa S, Kuo A, Madri JA. Angiogenesis. 2011 May; 2011 Jan 21. PMID: 21253820.", + "Pulsatile to-fro flow induces greater and sustained expression of tissue factor RNA in HUVEC than unidirectional laminar flow. Abe R, Yamashita N, Rochier A, Abe R, Nixon A, Madri JA, Sumpio BE. Am J Physiol Heart Circ Physiol. 2011 Apr; 2011 Jan 21. PMID: 21257914.", + "Myometrial wound healing post-Cesarean delivery in the MRL/MpJ mouse model of uterine scarring. Buhimschi CS, Zhao G, Sora N, Madri JA, Buhimschi IA. Am J Pathol. 2010 Jul; 2010 May 20. PMID: 20489145.", + "An implantable vascularized protein gel construct that supports human fetal hepatoblast survival and infection by hepatitis C virus in mice. Harding MJ, Lepus CM, Gibson TF, Shepherd BR, Gerber SA, Graham M, Paturzo FX, Rahner C, Madri JA, Bothwell AL, Lindenbach BD, Pober JS. PLoS One. 2010 Apr 1; 2010 Apr 1. PMID: 20376322.", + "Insights into monocyte-driven osteoclastogenesis and its link with hematopoiesis: regulatory roles of PECAM-1 (CD31) and SHP-1. Wu Y, Madri J. Crit Rev Immunol. 2010. PMID: 21083524.", + "Strain differences in behavioral and cellular responses to perinatal hypoxia and relationships to neural stem cell survival and self-renewal: Modeling the neurovascular niche. Li Q, Liu J, Michaud M, Schwartz ML, Madri JA. Am J Pathol. 2009 Nov; 2009 Oct 8. PMID: 19815710.", + "Modeling the neurovascular niche: implications for recovery from CNS injury. Madri JA. J Physiol Pharmacol. 2009 Oct. PMID: 20083857.", + "VEGF-A and Semaphorin3A: modulators of vascular sympathetic innervation. Long JB, Jay SM, Segal SS, Madri JA. Dev Biol. 2009 Oct 1; 2009 Jul 23. PMID: 19631637.", + "Characterization of RAGE, HMGB1, and S100beta in inflammation-induced preterm birth and fetal tissue injury. Buhimschi CS, Baumbusch MA, Dulay AT, Oliver EA, Lee S, Zhao G, Bhandari V, Ehrenkranz RA, Weiner CP, Madri JA, Buhimschi IA. Am J Pathol. 2009 Sep; 2009 Aug 13. PMID: 19679874.", + "Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future. Buhimschi CS, Bhandari V, Han YW, Dulay AT, Baumbusch MA, Madri JA, Buhimschi IA. Curr Opin Infect Dis. 2009 Jun. PMID: 19395960.", + "Bone marrow monocyte PECAM-1 deficiency elicits increased osteoclastogenesis resulting in trabecular bone loss. Wu Y, Tworkoski K, Michaud M, Madri JA. J Immunol. 2009 Mar 1. PMID: 19234161.", + "Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects. Nath AK, Krauthammer M, Li P, Davidov E, Butler LC, Copel J, Katajamaa M, Oresic M, Buhimschi I, Buhimschi C, Snyder M, Madri JA. PLoS One. 2009; 2009 Jan 19. PMID: 19156209.", + "Engineering angiogenesis following spinal cord injury: a coculture of neural progenitor and endothelial cells in a degradable polymer implant leads to an increase in vessel density and formation of the blood-spinal cord barrier. Rauch MF, Hynes SR, Bertram J, Redmond A, Robinson R, Williams C, Xu H, Madri JA, Lavik EB. Eur J Neurosci. 2009 Jan. PMID: 19120441.", + "Fibroblast-type reticular stromal cells regulate the lymph node vasculature. Chyou S, Ekland EH, Carpenter AC, Tzeng TC, Tian S, Michaud M, Madri JA, Lu TT. J Immunol. 2008 Sep 15. PMID: 18768843.", + "Matrix metalloproteinase 9 facilitates West Nile virus entry into the brain. Wang P, Dai J, Bai F, Kong KF, Wong SJ, Montgomery RR, Madri JA, Fikrig E. J Virol. 2008 Sep; 2008 Jul 16. PMID: 18632868.", + "Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction. Kalinowski L, Dobrucki LW, Meoli DF, Dione DP, Sadeghi MM, Madri JA, Sinusas AJ. J Appl Physiol (1985). 2008 May; 2008 Mar 20. PMID: 18356482.", + "Modeling the neurovascular niche: murine strain differences mimic the range of responses to chronic hypoxia in the premature newborn. Li Q, Michaud M, Stewart W, Schwartz M, Madri JA. J Neurosci Res. 2008 May 1. PMID: 18092360.", + "Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascades. Nath AK, Brown RM, Michaud M, Sierra-Honigmann MR, Snyder M, Madri JA. J Cell Biol. 2008 Apr 21; 2008 Apr 14. PMID: 18411306.", + "TNF-alpha induces MMP2 gelatinase activity and MT1-MMP expression in an in vitro model of nucleus pulposus tissue degeneration. Séguin CA, Pilliar RM, Madri JA, Kandel RA. Spine (Phila Pa 1976). 2008 Feb 15. PMID: 18277865.", + "Co-culture of primary neural progenitor and endothelial cells in a macroporous gel promotes stable vascular networks in vivo. Rauch MF, Michaud M, Xu H, Madri JA, Lavik EB. J Biomater Sci Polym Ed. 2008. PMID: 18973724.", + "Differential effects of shear stress and cyclic strain on Sp1 phosphorylation by protein kinase Czeta modulates membrane type 1-matrix metalloproteinase in endothelial cells. Kim JI, Cordova AC, Hirayama Y, Madri JA, Sumpio BE. Endothelium. 2008 Jan-Feb. PMID: 18568943.", + "PECAM-1: a multifaceted regulator of megakaryocytopoiesis. Wu Y, Welte T, Michaud M, Madri JA. Blood. 2007 Aug 1; 2007 Apr 5. PMID: 17412889.", + "MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization. Wu Y, Zhan L, Ai Y, Hannigan M, Gaestel M, Huang CK, Madri JA. Biochem Biophys Res Commun. 2007 Jun 22; 2007 Apr 24. PMID: 17481585.", + "Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth. Mosig RA, Dowling O, DiFeo A, Ramirez MC, Parker IC, Abe E, Diouri J, Aqeel AA, Wylie JD, Oblander SA, Madri J, Bianco P, Apte SS, Zaidi M, Doty SB, Majeska RJ, Schaffler MB, Martignetti JA. Hum Mol Genet. 2007 May 1; 2007 Mar 30. PMID: 17400654.", + "Juvenile hyaline fibromatosis and infantile systemic hyalinosis overlap associated with a novel mutation in capillary morphogenesis protein-2 gene. Antaya RJ, Cajaiba MM, Madri J, Lopez MA, Ramirez MC, Martignetti JA, Reyes-Múgica M. Am J Dermatopathol. 2007 Feb. PMID: 17284973.", + "PECAM-1 modulates thrombin-induced tissue factor expression on endothelial cells. Zhang JJ, Kelm RJ, Biswas P, Kashgarian M, Madri JA. J Cell Physiol. 2007 Feb. PMID: 17111362.", + "Modeling the neurovascular niche: VEGF- and BDNF-mediated cross-talk between neural stem cells and endothelial cells: an in vitro study. Li Q, Ford MC, Lavik EB, Madri JA. J Neurosci Res. 2006 Dec. PMID: 17061253.", + "Gamma delta T cells facilitate adaptive immunity against West Nile virus infection in mice. Wang T, Gao Y, Scully E, Davis CT, Anderson JF, Welte T, Ledizet M, Koski R, Madri JA, Barrett A, Yin Z, Craft J, Fikrig E. J Immunol. 2006 Aug 1. PMID: 16849493.", + "PECAM-1 affects GSK-3beta-mediated beta-catenin phosphorylation and degradation. Biswas P, Canosa S, Schoenfeld D, Schoenfeld J, Li P, Cheas LC, Zhang J, Cordova A, Sumpio B, Madri JA. Am J Pathol. 2006 Jul. PMID: 16816383.", + "The roles of nitric oxide in murine cardiovascular development. Nath AK, Madri JA. Dev Biol. 2006 Apr 1; 2006 Jan 25. PMID: 16442519.", + "Effects of a novel tylophorine analog on collagen-induced arthritis through inhibition of the innate immune response. You X, Pan M, Gao W, Shiah HS, Tao J, Zhang D, Koumpouras F, Wang S, Zhao H, Madri JA, Baker D, Cheng YC, Yin Z. Arthritis Rheum. 2006 Mar. PMID: 16508970.", + "A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks in vivo. Ford MC, Bertram JP, Hynes SR, Michaud M, Li Q, Young M, Segal SS, Madri JA, Lavik EB. Proc Natl Acad Sci U S A. 2006 Feb 21; 2006 Feb 10. PMID: 16473951.", + "Neutrophils lacking platelet-endothelial cell adhesion molecule-1 exhibit loss of directionality and motility in CXCR2-mediated chemotaxis. Wu Y, Stabach P, Michaud M, Madri JA. J Immunol. 2005 Sep 15. PMID: 16148090.", + "Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alphavbeta3 integrin after murine hindlimb ischemia. Hua J, Dobrucki LW, Sadeghi MM, Zhang J, Bourke BN, Cavaliere P, Song J, Chow C, Jahanshad N, van Royen N, Buschmann I, Madri JA, Mendizabal M, Sinusas AJ. Circulation. 2005 Jun 21; 2005 Jun 13. PMID: 15956134.", + "Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response. Peng T, Hao L, Madri JA, Su X, Elias JA, Stahl GL, Squinto S, Wang Y. J Clin Invest. 2005 Jun; 2005 May 12. PMID: 15902311.", + "Identification of the regions of PECAM-1 involved in beta- and gamma-catenin associations. Biswas P, Zhang J, Schoenfeld JD, Schoenfeld D, Gratzinger D, Canosa S, Madri JA. Biochem Biophys Res Commun. 2005 Apr 22. PMID: 15766557.", + "MAPKs (ERK1/2, p38) and AKT can be phosphorylated by shear stress independently of platelet endothelial cell adhesion molecule-1 (CD31) in vascular endothelial cells. Sumpio BE, Yun S, Cordova AC, Haga M, Zhang J, Koh Y, Madri JA. J Biol Chem. 2005 Mar 25; 2005 Jan 24. PMID: 15668248.", + "Enhanced susceptibility to endotoxic shock and impaired STAT3 signaling in CD31-deficient mice. Carrithers M, Tandon S, Canosa S, Michaud M, Graesser D, Madri JA. Am J Pathol. 2005 Jan. PMID: 15632011.", + "MMP-2 null mice exhibit an early onset and severe experimental autoimmune encephalomyelitis due to an increase in MMP-9 expression and activity. Esparza J, Kruse M, Lee J, Michaud M, Madri JA. FASEB J. 2004 Nov. PMID: 15522913.", + "A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels. Hallaq H, Pinter E, Enciso J, McGrath J, Zeiss C, Brueckner M, Madri J, Jacobs HC, Wilson CM, Vasavada H, Jiang X, Bogue CW. Development. 2004 Oct. PMID: 15459110.", + "Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brain-derived endothelial cells. Kim H, Li Q, Hempstead BL, Madri JA. J Biol Chem. 2004 Aug 6; 2004 May 28. PMID: 15169782.", + "Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. Meoli DF, Sadeghi MM, Krassilnikova S, Bourke BN, Giordano FJ, Dione DP, Su H, Edwards DS, Liu S, Harris TD, Madri JA, Zaret BL, Sinusas AJ. J Clin Invest. 2004 Jun. PMID: 15199403.", + "Nitric oxide modulates murine yolk sac vasculogenesis and rescues glucose induced vasculopathy. Nath AK, Enciso J, Kuniyasu M, Hao XY, Madri JA, Pinter E. Development. 2004 May. PMID: 15128676.", + "Histamine inhibits conducted vasodilation through endothelium-derived NO production in arterioles of mouse skeletal muscle. Payne GW, Madri JA, Sessa WC, Segal SS. FASEB J. 2004 Feb. PMID: 14769822.", + "Transcriptional up-regulation of endothelial cell matrix metalloproteinase-2 in response to extracellular cues involves GATA-2. Han X, Boyd PJ, Colgan S, Madri JA, Haas TL. J Biol Chem. 2003 Nov 28; 2003 Sep 25. PMID: 14512418.", + "PECAM-1: old friend, new partners. Ilan N, Madri JA. Curr Opin Cell Biol. 2003 Oct. PMID: 14519385.", + "Vascular endothelial growth factor expression, beta-catenin tyrosine phosphorylation, and endothelial proliferative behavior: a pathway for transformation? Ilan N, Tucker A, Madri JA. Lab Invest. 2003 Aug. PMID: 12920240.", + "Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho. Gratzinger D, Canosa S, Engelhardt B, Madri JA. FASEB J. 2003 Aug. PMID: 12890700.", + "Abolition of arteriolar dilation but not constriction to histamine in cremaster muscle of eNOS-/- mice. Payne GW, Madri JA, Sessa WC, Segal SS. Am J Physiol Heart Circ Physiol. 2003 Aug; 2003 Apr 10. PMID: 12689855.", + "Maternal diabetes: effects on embryonic vascular development--a vascular endothelial growth factor-A-mediated process. Madri JA, Enciso J, Pinter E. Pediatr Dev Pathol. 2003 Jul-Aug. PMID: 14692647.", + "PECAM-1 promotes beta-catenin accumulation and stimulates endothelial cell proliferation. Biswas P, Canosa S, Schoenfeld J, Schoenfeld D, Tucker A, Madri JA. Biochem Biophys Res Commun. 2003 Mar 28. PMID: 12646189.", + "Lack of platelet endothelial cell adhesion molecule-1 attenuates foreign body inflammation because of decreased angiogenesis. Solowiej A, Biswas P, Graesser D, Madri JA. Am J Pathol. 2003 Mar. PMID: 12598328.", + "Elevated glucose inhibits VEGF-A-mediated endocardial cushion formation: modulation by PECAM-1 and MMP-2. Enciso JM, Gratzinger D, Camenisch TD, Canosa S, Pinter E, Madri JA. J Cell Biol. 2003 Feb 17. PMID: 12591918.", + "Platelet-endothelial cell adhesion molecule-1 modulates endothelial migration through its immunoreceptor tyrosine-based inhibitory motif. Gratzinger D, Barreuther M, Madri JA. Biochem Biophys Res Commun. 2003 Jan 31. PMID: 12535670.", + "The evolving roles of cell surface proteases in health and disease: implications for developmental, adaptive, inflammatory, and neoplastic processes. Madri JA. Curr Top Dev Biol. 2003. PMID: 12696757.", + "Disrupted synaptic development in the hypoxic newborn brain. Curristin SM, Cao A, Stewart WB, Zhang H, Madri JA, Morrow JS, Ment LR. Proc Natl Acad Sci U S A. 2002 Nov 26; 2002 Nov 15. PMID: 12438650.", + "Transcription factor Sp1 phosphorylation induced by shear stress inhibits membrane type 1-matrix metalloproteinase expression in endothelium. Yun S, Dardik A, Haga M, Yamashita A, Yamaguchi S, Koh Y, Madri JA, Sumpio BE. J Biol Chem. 2002 Sep 20; 2002 Jul 1. PMID: 12093818.", + "Cyclic strain stimulates early growth response gene product 1-mediated expression of membrane type 1 matrix metalloproteinase in endothelium. Yamaguchi S, Yamaguchi M, Yatsuyanagi E, Yun SS, Nakajima N, Madri JA, Sumpio BE. Lab Invest. 2002 Jul. PMID: 12118097.", + "Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system. Ogunshola OO, Antic A, Donoghue MJ, Fan SY, Kim H, Stewart WB, Madri JA, Ment LR. J Biol Chem. 2002 Mar 29; 2002 Jan 3. PMID: 11777931.", + "Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice. Graesser D, Solowiej A, Bruckner M, Osterweil E, Juedes A, Davis S, Ruddle NH, Engelhardt B, Madri JA. J Clin Invest. 2002 Feb. PMID: 11827998.", + "Astrocyte-derived VEGF mediates survival and tube stabilization of hypoxic brain microvascular endothelial cells in vitro. Chow J, Ogunshola O, Fan SY, Li Y, Ment LR, Madri JA. Brain Res Dev Brain Res. 2001 Sep 23. PMID: 11557101.", + "pp60(c-src) modulates microvascular endothelial phenotype and in vitro angiogenesis. Marx M, Warren SL, Madri JA. Exp Mol Pathol. 2001 Jun. PMID: 11417999.", + "Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion. Xie B, Zhao J, Kitagawa M, Durbin J, Madri JA, Guan JL, Fu XY. J Biol Chem. 2001 Jun 1; 2001 Feb 21. PMID: 11278462.", + "Hyperglycemia-induced vasculopathy in the murine conceptus is mediated via reductions of VEGF-A expression and VEGF receptor activation. Pinter E, Haigh J, Nagy A, Madri JA. Am J Pathol. 2001 Apr. PMID: 11290536.", + "Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse. Ilan N, Cheung L, Miller S, Mohsenin A, Tucker A, Madri JA. Dev Biol. 2001 Apr 1. PMID: 11254359.", + "PECAM-1 shedding during apoptosis generates a membrane-anchored truncated molecule with unique signaling characteristics. Ilan N, Mohsenin A, Cheung L, Madri JA. FASEB J. 2001 Feb. PMID: 11156952.", + "Matrix metalloproteinase activity is required for activity-induced angiogenesis in rat skeletal muscle. Haas TL, Milkiewicz M, Davis SJ, Zhou AL, Egginton S, Brown MD, Madri JA, Hudlicka O. Am J Physiol Heart Circ Physiol. 2000 Oct. PMID: 11009439.", + "Lauder Hall 310 Cedar Street PO Box 208023 New Haven, CT 06520-8023 Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Magid-Bernstein Lab", + "lab_url": "https://medicine.yale.edu/lab/magid-bernstein/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/magid-bernstein/publications/", + "publications": [ + "Yale School of Medicine /", + "Neurology /", + "Research", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Publications", + "", + "", + "", + "", + "", + "", + "Operationalizing a complex acute clinical trial: Lessons from the BEACH study. Sorensen G, Remillard W, Schlechter M, Kampp M, Whisler Brady C, Kildahl K, Mould A, Ziai W, Lane K, Van Eldik LJ, Distasio A, Lu J, Sansing LH, Hanley DF, Magid-Bernstein J. J Clin Transl Sci. 2025; 2025 Sep 12. PMID: 41040632.", + "Early CSF inflammatory markers after aneurysmal subarachnoid hemorrhage and their relationship to disease severity and shunt placement. Magid-Bernstein J, Yan J, Herman AL, He Z, Johnson CW, Beatty H, Choi R, Velazquez S, Sorensen G, Jayasundara S, Grychowski L, Amllay A, Falcone GJ, Kim J, Petersen N, O'Keefe L, Gilmore EJ, Matouk C, Sheth KN, Sansing LH. J Stroke Cerebrovasc Dis. 2025 Sep; 2025 Jul 8. PMID: 40639751.", + "Impact of Nimodipine-Induced Blood Pressure Reductions on Cerebral Autoregulation and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage. Stoehr KA, Bartolome D, Jayasundara S, Thinzar P, Vargas D, Kim J, Magid-Bernstein J, O'Keefe LM, de Havenon A, Hebert R, Matouk C, Sheth KN, Gilmore EJ, Ortega-Gutierrez S, Petersen NH. Neurocrit Care. 2025 Aug 22; 2025 Aug 22. PMID: 40847251.", + "Do the Benefits of Blood Pressure Control in ICH Outweigh the Risks? Magid-Bernstein J, Murthy SB. JAMA Neurol. 2025 Jun 1. PMID: 40257789.", + "Operationalizing a complex acute clinical trial: Lessons from the BEACH study. Sorensen G, Remillard W, Schlechter M, Kampp M, Sansing LH, Brady CW, Kidahl K, Ziai W, Van Eldik L, Distasio A, Lu J, Magid-Bernstein J, Hanley D. medRxiv. 2025 Mar 31; 2025 Mar 31. PMID: 40236420.", + "Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage. Rivier CA, Renedo D, Marini S, Magid-Bernstein JR, de Havenon A, Rosand J, Hanley DF, Ziai WC, Mayer SA, Woo D, Sansing LH, Sheth KN, Anderson CD, Falcone GJ. Ann Neurol. 2025 Feb; 2024 Nov 5. PMID: 39499118.", + "Characterization of CSF inflammatory markers after hemorrhagic stroke and their relationship to disease severity. Magid-Bernstein J, Yan J, Herman AL, He Z, Johnson CW, Beatty H, Choi R, Velazquez S, Neeman E, Falcone G, Kim J, Petersen N, Gilmore EJ, Matouk C, Sheth K, Sansing L. medRxiv. 2023 Dec 7; 2023 Dec 7. PMID: 38106157.", + "Guidelines in Action: Management of Acute and Chronic Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage. Parasram M, Park J, Al-Dulaimi MW, Magid-Bernstein JR. Stroke. 2023 Dec; 2023 Oct 16. PMID: 37842781.", + "Acute and subacute neurovascular impact of cryptogenic air emboli. Gummerson CE, Parasram M, Peng TJ, Picard JM, Kahn PA, Angelus E, Bhatt S, de Havenon A, Jasne AS, Magid-Bernstein J. Surg Neurol Int. 2023; 2023 Aug 11. PMID: 37680929.", + "Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Ammar AA, Elsamadicy AA, Ammar MA, Reeves BC, Koo AB, Falcone GJ, Hwang DY, Petersen N, Kim JA, Beekman R, Prust M, Magid-Bernstein J, Acosta JN, Herbert R, Sheth KN, Matouk CC, Gilmore EJ. Clin Neurol Neurosurg. 2023 Mar; 2023 Feb 9. PMID: 36791588.", + "Intraventricular Hemorrhage Expansion in the CLEAR III Trial: A Post Hoc Exploratory Analysis. Roh DJ, Asonye IS, Carvalho Poyraz F, Magid-Bernstein JR, Joiner EF, Avadhani R, Awad I, Hanley DF, Ziai WC, Murthy SB. Stroke. 2022 Jun; 2022 Jan 28. PMID: 35086362.", + "Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions. Magid-Bernstein J, Girard R, Polster S, Srinath A, Romanos S, Awad IA, Sansing LH. Circ Res. 2022 Apr 15; 2022 Apr 14. PMID: 35420918.", + "Cerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials. Magid-Bernstein JR, Li Y, Cho SM, Piran PJ, Roh DJ, Gupta A, Shoamanesh A, Merkler A, Zhang C, Avadhani R, Montano N, Iadecola C, Falcone GJ, Sheth KN, Qureshi AI, Rosand J, Goldstein J, Awad I, Hanley DF, Kamel H, Ziai WC, Murthy SB. Neurology. 2022 Mar 8; 2021 Dec 22. PMID: 34937780.", + "Reversible Cerebral Vasoconstriction Syndrome: Symptoms, Incidence, and Resource Utilization in a Population-Based US Cohort. Magid-Bernstein J, Omran SS, Parikh NS, Merkler AE, Navi B, Kamel H. Neurology. 2021 Jul 19; 2021 Jul 19. PMID: 34050007.", + "Impacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage. Magid-Bernstein J, Beaman CB, Carvalho-Poyraz F, Boehme A, Hod EA, Francis RO, Elkind MSV, Agarwal S, Park S, Claassen J, Connolly ES, Roh D. Blood. 2021 May 13. PMID: 33649761.", + "Red Blood Cell Transfusions and Outcomes After Intracerebral Hemorrhage. Roh DJ, Carvalho Poyraz F, Magid-Bernstein J, Elkind MSV, Agarwal S, Park S, Claassen J, Connolly ES, Hod E, Murthy SB. J Stroke Cerebrovasc Dis. 2020 Dec; 2020 Sep 26. PMID: 32992186.", + "A rare case of HIV CNS escape in a patient previously considered a viral controller. Magid-Bernstein J, Guo CY, Chow FC, Thakur KT. Int J STD AIDS. 2020 Jun. PMID: 32538333.", + "Low hemoglobin and hematoma expansion after intracerebral hemorrhage. Roh DJ, Albers DJ, Magid-Bernstein J, Doyle K, Hod E, Eisenberger A, Murthy S, Witsch J, Park S, Agarwal S, Connolly ES, Elkind MSV, Claassen J. Neurology. 2019 Jul 23; 2019 Jun 17. PMID: 31209179.", + "Prognostic Value of the Neurological Examination in Cardiac Arrest Patients After Therapeutic Hypothermia. Matthews EA, Magid-Bernstein J, Sobczak E, Velazquez A, Falo CM, Park S, Claassen J, Agarwal S. Neurohospitalist. 2018 Apr; 2017 Oct 29. PMID: 29623156.", + "Human CD39(+) T(reg) Cells Express Th17-Associated Surface Markers and Suppress IL-17 via a Stat3-Dependent Mechanism. Magid-Bernstein JR, Rohowsky-Kochan CM. J Interferon Cytokine Res. 2017 Apr; 2017 Feb 24. PMID: 28387597.", + "Use of early head CT following out-of-hospital cardiopulmonary arrest. Reynolds AS, Matthews E, Magid-Bernstein J, Rodriguez A, Park S, Claassen J, Agarwal S. Resuscitation. 2017 Apr; 2017 Jan 3. PMID: 28057527.", + "Unexpected Rapid Improvement and Neurogenic Stunned Myocardium in a Patient With Acute Motor Axonal Neuropathy: A Case Report and Literature Review. Magid-Bernstein J, Al-Mufti F, Merkler AE, Roh D, Patel S, May TL, Agarwal S, Claassen J, Park S. J Clin Neuromuscul Dis. 2016 Mar. PMID: 26905914.", + "Case report: cytokine and CD4+ T-cell profiles of monozygotic twins with autism and divergent comorbidities and drug treatment. Magid-Bernstein J, Mahajan K, Lincoln J, Ming X, Rohowsky-Kochan C. J Child Neurol. 2015 Mar; 2014 Apr 15. PMID: 24736120.", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Makhani Lab", + "lab_url": "https://medicine.yale.edu/lab/makhani/", + "research_bio": "INFORMATION FOR The Makhani lab is part of the Department of Pediatrics and the Department of Neurology at the Yale School of Medicine. Our lab’s work is largely translational and involves collaborations with radiologists and immune-biologists. Our work is focused on studying Multiple Sclerosis (MS) and related neuro-immunological disorders in children. Our specific goal is to identify risk factors for these conditions in children and to translate our findings to the development of interventions to prevent disease. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Manuelidis Lab", + "lab_url": "https://medicine.yale.edu/lab/manuelidis/", + "research_bio": "INFORMATION FOR We maintain and consult on the broad archival diagnostic and educational neuropathology specimens of YNHH and other sources from 1951-1996. We also make available other unusual specimens collected by our team according to APHIS guidelines as well as preservation of irreplaceable materials. Our team contributes to the development of rational policies for agricultural and medical practices such as those involving the national blood supply. (LM is a member of the FDA TSE advisory committee and has served on an advisory panel on Alzheimer’s Disease and related disorders to the Us Department of Health). In addition, we: Copy Link Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/manuelidis/particles/", + "publications": [ + "Yale School of Medicine /", + "Surgery /", + "Neuropathology /", + "CJD Agents", + "Poetry", + "Neuropathology", + "Infectious Particles", + "Journals covers", + "CJD Discoveries", + "Writings", + "DNA-Chromosomes", + "Cushing-Eisenhardt Collaboration", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "CJD Agents", + "Infectious Particles", + "CJD Discoveries", + "DNA-Chromosomes", + "Poetry", + "Journals covers", + "Writings", + "Cushing-Eisenhardt Collaboration", + "Neuropathology", + "", + "", + "", + "", + "", + "", + "Removal of PrP in brain homogenates does not reduce the infectivity PMID 21793014", + "When the “infectious” PrP amyloid increases, infectivity falls by 10,000 fold PMID 22509412", + "All infectious preparations contain circular DNAs of >500nt by molecular analysis PMID 21165784", + "CJD and scrapie agent particles, as viral structures, require nucleic acids to infect cells Download PDF", + "Infectious particles, stress, and induced prion amyloids Download PDF", + "Continuous production of prions after infectious particles are eliminated Download PDF", + "", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Martin Lab", + "lab_url": "https://medicine.yale.edu/lab/martin/", + "research_bio": "INFORMATION FOR Copy Link Our overall goal is to understand how regulation of the muscular layer of blood vessels contributes to normal vessel function and to cardiovascular disease. Hyperproliferation or dysfunction in vascular smooth muscle cells contributes to atherosclerosis, hypertension, organ transplant failure, and failure of revascularization therapies such as balloon angioplasty or bypass surgery. By understanding the regulatory mechanisms of vascular smooth muscle, we aim to develop new therapies for treatment and prevention of cardiovascular diseases. Key areas of interest:Vascular smooth muscle; Differentiation; Signal transduction; Transcription; Epigenetics Disease models:Atherosclerosis, Intimal Hyperplasia, Transplant Vasculopathy, Obesity and Diabetes", + "publications_page": null, + "publications": null + }, + { + "lab_name": "McAlpine Lab", + "lab_url": "https://medicine.yale.edu/lab/mcalpine/", + "research_bio": "INFORMATION FOR Long COVID is a pressing public health issue affecting almost millions of Americans. Our goal is to understand and address the mechanisms that damage nervous system after COVID-19. Our studies focus on the underlying neuropathophysiology of Long COVID using a variety of modalities. All our methods are concentrated on imaging, data, and samples collected from humans to understand damage to the central, autonomic, and peripheral nervous systems. Our research participants are recruited locally and throughout the United States. We work with a wide range of collaborators at Yale University and beyond. The main modality we use is advanced research-based MRI of the brain. We apply a wide range of sequences including structural, vascular, and other techniques. Other tools we have recently applied include vascular, neuronal, and immunologic biomarker testing, as well as extensive neuropsychological testing. Copy Link Copy Link Copy Link Copy Link Assistant Professor of Neurology Postgraduate Associate Postgraduate Associate Copy Link", + "publications_page": "https://medicine.yale.edu/lab/mcalpine/publications/", + "publications": [ + "Yale School of Medicine /", + "Neurology /", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Publications", + "", + "", + "", + "", + "", + "", + "CSF immune cell alterations in women with neuropsychiatric Long COVID Orlinick B, Mehta S, McAlpine L , Khoshbakht S, Fertuzinhos S, Nelson A, Chiarella J , Das B, Patel V, Filippidis P, Corley M, Spudich S , Farhadian S . CSF immune cell alterations in women with neuropsychiatric Long COVID . The Journal Of Infectious Diseases 2025, jiaf468. PMID: 40920586 , DOI: 10.1093/infdis/jiaf468 . Peer-Reviewed Original Research Altmetric Concepts Peripheral blood mononuclear cells Cerebrospinal fluid Peripheral blood mononuclear cell samples Immune cell alterations Blood mononuclear cells Long COVID Acute COVID-19 Lumbar puncture Genes related to oxidative stress Mononuclear cells Androgen responsiveness Cellular stress pathways Molecular profiling Neurological syndrome Blood draw Immune response Cell alterations COVID status Reactive oxygen species P53 response Stress pathways Women MTORC1 signaling Oxidative stress Lipid metabolism", + "What is brain fog? Mcalpine L . What is brain fog? Brain & Life 2025, 21: 29-29. DOI: 10.1097/01.nnn.0001118424.96839.ae . Peer-Reviewed Original Research", + "Internal Tremors and Vibrations in Long COVID: A Cross-Sectional Study Zhou T, Sawano M , Arun A, Caraballo C , Michelsen T, McAlpine L , Bhattacharjee B , Lu Y , Khera R , Huang C , Warner F , Herrin J , Iwasaki A , Krumholz H . Internal Tremors and Vibrations in Long COVID: A Cross-Sectional Study . The American Journal Of Medicine 2024, 138: 1010-1018.e14. PMID: 39069199 , PMCID: PMC12023347 , DOI: 10.1016/j.amjmed.2024.07.008 . Peer-Reviewed Original Research Citations Altmetric Concepts New-onset conditions Internal tremor Long COVID symptoms COVID symptoms Non-Hispanic whites Cross-sectional study Quality of life Visual analogue scale Worse health Health status Study participants Demographic characteristics Analogue scale Outcome variables Neurological conditions Long COVID Mast cell disorders Treatment experience Health Comorbidities Symptoms Median age People Cell disorders", + "Case-Control Study of Individuals With Small Fiber Neuropathy After COVID-19 McAlpine L , Zubair A , Joseph P, Spudich S . Case-Control Study of Individuals With Small Fiber Neuropathy After COVID-19 . Neurology Neuroimmunology & Neuroinflammation 2024, 11: e200244. PMID: 38630952 , PMCID: PMC11087026 , DOI: 10.1212/nxi.0000000000200244 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Autonomic Nervous System Diseases Case-Control Studies COVID-19 Fatigue Syndrome, Chronic Female Humans Immunoglobulins, Intravenous Male Middle Aged Post-Acute COVID-19 Syndrome Retrospective Studies Small Fiber Neuropathy Concepts Invasive cardiopulmonary exercise testing Small fiber neuropathy Case-control study Fiber neuropathy Skin biopsies Clinical response to treatment Neurovascular dysregulation Treated with IVIG Retrospective chart review Case-control study of individuals Retrospective cohort study Response to treatment Cardiopulmonary exercise testing Class III evidence Myalgic encephalomyelitis/chronic fatigue syndrome IVIG group Clinical response Neuropathic symptoms Chart review IVIG Study of individuals Cohort study III evidence Clinical trials COVID-19 illness", + "Focal White Matter Damage in Individuals with Cognitive Impairment After COVID-19 (P11-13.004) McAlpine L , Nelson A, Chiarella J , Lacadie C, Farhadian S , Constable T , Spudich S . Focal White Matter Damage in Individuals with Cognitive Impairment After COVID-19 (P11-13.004) . Neurology 2024, 102 DOI: 10.1212/wnl.0000000000204666 . Peer-Reviewed Original Research", + "Virology, ecology, epidemiology, pathology, and treatment of eastern equine encephalitis Zubair A , McAlpine L , Gobeske K . Virology, ecology, epidemiology, pathology, and treatment of eastern equine encephalitis . Journal Of The Neurological Sciences 2024, 457: 122886. PMID: 38278094 , DOI: 10.1016/j.jns.2024.122886 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Disease Outbreaks Encephalitis Virus, Eastern Equine Encephalomyelitis, Eastern Equine Horses Humans Concepts Eastern equine encephalitis Equine encephalitis Neuroinvasive arboviral disease Transmission cycle Viral diseases Arboviral diseases Infection rate Public health burden Ecological conditions Health burden Epidemiology of arboviral diseases Outbreak North America", + "Self-Reported Neuropsychiatric Post–COVID-19 Condition and CSF Markers of Neuroinflammation Farhadian S , Reisert H, McAlpine L , Chiarella J , Kosana P, Yoon J , Spudich S . Self-Reported Neuropsychiatric Post–COVID-19 Condition and CSF Markers of Neuroinflammation . JAMA Network Open 2023, 6: e2342741. PMID: 37948085 , PMCID: PMC10638645 , DOI: 10.1001/jamanetworkopen.2023.42741 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Brain COVID-19 Humans Neuroinflammatory Diseases Self Report Concepts Blood-brain barrier disruption Cerebrospinal fluid markers Case-control study Post COVID-19 condition Neuropsychiatric symptoms Barrier disruption CSF markers Fluid markers Neuroinflammation Markers Symptoms", + "Plasmapheresis Versus Intravenous Immunoglobulin in Patients With Autoimmune Neuromuscular and Neuro-immunological Conditions Zubair A , Rethana M, Ma A, McAlpine L , Abulaban A, Munro B, Patwa H , Nowak R , Roy B . Plasmapheresis Versus Intravenous Immunoglobulin in Patients With Autoimmune Neuromuscular and Neuro-immunological Conditions . Journal Of Clinical Neuromuscular Disease 2023, 25: 11-17. PMID: 37611265 , DOI: 10.1097/cnd.0000000000000439 . Peer-Reviewed Original Research Citations MeSH Keywords and Concepts MeSH Keywords Adult Aged Autoimmune Diseases of the Nervous System Drug-Related Side Effects and Adverse Reactions Guillain-Barre Syndrome Humans Immune System Diseases Immunoglobulins, Intravenous Myasthenia Gravis Plasmapheresis Retrospective Studies Concepts Neuro-immunological disease Intravenous immunoglobulin Autoimmune neurological disorders Autoimmune neuromuscular disorder Adult patients Elderly patients Neurological disorders Neuromuscular disorders Chronic inflammatory demyelinating polyradiculoneuropathy National Inpatient Sample database National Inpatient Sample dataset Inflammatory demyelinating polyradiculoneuropathy Safe therapeutic choice Retrospective chart review Appropriate clinical setting Side effect profile Demyelinating polyradiculoneuropathy IVIG use Chart review Younger patients Myasthenia gravis Effect profile Medical history Primary diagnosis Therapeutic choice", + "Neurological sequelae of vaccines McAlpine L , Zubair A . Neurological sequelae of vaccines . Neurological Sciences 2023, 44: 1505-1513. PMID: 36622478 , PMCID: PMC9838503 , DOI: 10.1007/s10072-022-06581-z . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Encephalomyelitis, Acute Disseminated Guillain-Barre Syndrome Humans Myelitis, Transverse Vaccination Vaccines Concepts Guillain-Barre syndrome Infectious diseases Neurological sequelae Acute disseminated encephalomyelitis Systemic immune activation Mild adverse reactions Disseminated encephalomyelitis Local soreness Neurologic sequelae Transverse myelitis Adverse events Recent vaccination Immune activation Adverse reactions Disease onset Potential pathogenesis Safe option Potential treatment Early identification Vaccine Sequelae Rapid diagnosis Adverse effects Typical symptoms Disease", + "Anti-SARS-CoV-2 and Autoantibody Profiling of a COVID-19 Patient With Subacute Psychosis Who Remitted After Treatment With Intravenous Immunoglobulin McAlpine L , Lifland B, Check J, Angarita G, Ngo T, Chen P, Dandekar R, Alvarenga B, Browne W, Pleasure S, Wilson M, Spudich S , Farhadian S , Bartley C. Anti-SARS-CoV-2 and Autoantibody Profiling of a COVID-19 Patient With Subacute Psychosis Who Remitted After Treatment With Intravenous Immunoglobulin . Biological Psychiatry 2022, 93: e25-e29. PMID: 36481066 , PMCID: PMC9722219 , DOI: 10.1016/j.biopsych.2022.09.007 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords COVID-19 Humans Immunoglobulins, Intravenous Psychotic Disorders SARS-CoV-2 Concepts COVID-19 patients SARS-CoV-2 Intravenous immunoglobulin Autoantibody profiling Patients Psychosis Immunoglobulin", + "Intravenous Immune Globulins vs Plasma Exchange Usage in Patients with Neuromuscular and Neuro-immunological Conditions (P4-13.007) Rethana M, Zubair A , Ma A, McAlpine L , Abulaban A, Nowak R , Roy B . Intravenous Immune Globulins vs Plasma Exchange Usage in Patients with Neuromuscular and Neuro-immunological Conditions (P4-13.007) . Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.2392 . Peer-Reviewed Original Research Concepts Intravenous immune globulin Immune globulin Patients Neuromuscular Globulin", + "Case Series: Post-COVID Small Fiber Neuropathy (P9-9.002) McAlpine L , Zubair A , Spudich S . Case Series: Post-COVID Small Fiber Neuropathy (P9-9.002) . Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.348 . Peer-Reviewed Original Research Citations", + "Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients (2402) McAlpine L , Zubair A , Maran I, Chojecka P, Lleva P , Jasne A , Navaratnam D , Matouk C , Schindler J , Chun H, Lee A , Spudich S , Sharma R, Sansing L . Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients (2402) . Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.2402 . 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Sparrow Fellowship in the Clinical Neuroscience of Autism", + "Hilibrand Postdoctoral Fellowship in Autism Research", + "Sara S. Sparrow Fellowship in the Clinical Neuroscience of Autism", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Home", + "Publications", + "Posters", + "Books", + "Article Summaries", + "", + "", + "", + "", + "", + "", + "Reduced social prioritization: An underlying mechanism driving slower latency to look at faces in autism. Griffin JW, Willis HC, Dommer K, Naples A, Dawson G, Jeste S, Faja S, Bernier R, Kleinhans N, Levin A, Hellemann G, Senturk D, Dziura J, Sugar C, Webb SJ, McPartland JC, Shic F. J Psychopathol Clin Sci. 2025 Oct 16; 2025 Oct 16. PMID: 41100279.", + "Number of alpha peaks in the electroencephalogram is associated with clinical phenotype and copy number variation in youths with autism. Arutiunian V, Opdahl M, Sullivan CAW, Santhosh M, Neuhaus E, Borland H, Bernier RA, Bookheimer SY, Dapretto M, Jack A, Jeste S, McPartland JC, Naples A, Van Horn JD, Pelphrey KA, Webb SJ, Gupta AR. Biol Psychiatry Cogn Neurosci Neuroimaging. 2025 Oct 14; 2025 Oct 14. PMID: 41101705.", + "Do in-scanner tasks outperform rest for predicting autistic traits using functional connectivity data? Horien C, Mandino F, Greene AS, Shen X, Powell K, Vernetti A, O'Connor D, Adkinson BD, Tejavibulya L, McPartland JC, Volkmar FR, Chun M, Chawarska K, Lake EMR, Rosenberg MD, Satterthwaite T, Scheinost D, Finn E, Constable RT. medRxiv. 2025 Sep 16; 2025 Sep 16. PMID: 39867399.", + "Widespread associations between behavioral metrics and brain microstructure in ASD suggest age mediates subtypes of ASD. Ressa HJ, Newman BT, Jacokes Z, McPartland JC, Kleinhans NM, Druzgal TJ, Pelphrey KA, Van Horn JD. Imaging Neurosci (Camb). 2025; 2025 Sep 10. PMID: 40948605.", + "Parsing the heterogeneity of social motivation in autism. Chetcuti L, Hardan AY, Spackman E, Loth E, McPartland JC, Frazier TW, Youngstrom EA, Uljarevic M. J Child Psychol Psychiatry. 2025 Sep; 2025 Mar 16. PMID: 40091308.", + "Face perception, attention, and memory as predictors of social change in autistic children. Webb SJ, Kwan B, Bernier R, Charwarska K, Dawson G, Dziura J, Faja S, Hellmann G, Jeste S, Kleinhans N, Levin A, Naples A, Sabatos-DeVito M, Şentürk D, Shic F, Sugar C, McPartland JC. J Neurodev Disord. 2025 Aug 30; 2025 Aug 30. PMID: 40885894.", + "Advancing scientific understanding of the drive to socially engage: from broad constructs to transdiagnostic 'building blocks'. Chetcuti L, Hardan AY, Frazier TW, Loth E, McPartland JC, Youngstrom EA, Uljarevic M. Mol Psychiatry. 2025 Aug 26; 2025 Aug 26. PMID: 40858780.", + "Structural determinants of signal speed: Estimated axonal latency and its multimodal validation during face processing in autism. Coleman CR, Nance MG, Jacokes Z, Druzgal TJ, Arutiunian V, Kresse A, Sullivan CAW, Santhosh M, Neuhaus E, Borland H, Bernier RA, Bookheimer SY, Dapretto M, Jack A, Kleinhans NM, Jeste S, McPartland JC, Naples A, Geschwind D, Gupta AR, Webb SJ, Pelphrey KA, Van Horn JD, Newman BT, Puglia MH. bioRxiv. 2025 Jun 24; 2025 Jun 24. PMID: 40166310.", + "Enhancer-driven gene regulatory network of forebrain human development provides insights into autism. Jourdon A, Mariani J, Natu A, Wu F, Li B, Capauto D, Hagy KT, Norton S, Tomasini L, Safi A, Amiri A, Schreiner J, Nguyen CK, Nolan N, Nelson MP, Ramos DM, Ward ME, Szekely A, McPartland JC, Pelphrey K, Ventola P, Chawarska K, Gersbach CA, Crawford GE, Abyzov A, Vaccarino FM. bioRxiv. 2025 May 11; 2025 May 11. PMID: 40654911.", + "A common genetic variant in the Neurexin family member CNTNAP2 is related to language but not communication skills in youth with Autism Spectrum Disorder. 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PMID: 33318557.", + "N400 amplitude, latency, and variability reflect temporal integration of beat gesture and pitch accent during language processing. Morett LM, Landi N, Irwin J, McPartland JC. Brain Res. 2020 Nov 15; 2020 Aug 17. PMID: 32818527.", + "Contrast Is in the Eye of the Beholder: Infelicitous Beat Gesture Increases Cognitive Load During Online Spoken Discourse Comprehension. Morett LM, Roche JM, Fraundorf SH, McPartland JC. Cogn Sci. 2020 Oct. PMID: 33073404.", + "Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder. Constable PA, Ritvo ER, Ritvo AR, Lee IO, McNair ML, Stahl D, Sowden J, Quinn S, Skuse DH, Thompson DA, McPartland JC. J Autism Dev Disord. 2020 Aug. PMID: 32034650.", + "Sex Differences in Functional Connectivity of the Salience, Default Mode, and Central Executive Networks in Youth with ASD. Lawrence KE, Hernandez LM, Bowman HC, Padgaonkar NT, Fuster E, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, Geschwind DH, McPartland JC, Nelson CA, Webb SJ, Pelphrey KA, Green SA, Bookheimer SY, Dapretto M. Cereb Cortex. 2020 Jul 30. PMID: 32350530.", + "Autism Spectrum Disorder and Schizophrenia Are Better Differentiated by Positive Symptoms Than Negative Symptoms. Trevisan DA, Foss-Feig JH, Naples AJ, Srihari V, Anticevic A, McPartland JC. Front Psychiatry. 2020; 2020 Jun 11. PMID: 32595540.", + "Neural responsivity to social rewards in autistic female youth. Lawrence KE, Hernandez LM, Eilbott J, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, Geschwind DH, McPartland JC, Nelson CA, Webb SJ, Pelphrey KA, Bookheimer SY, Dapretto M. Transl Psychiatry. 2020 Jun 2; 2020 Jun 2. PMID: 32488083.", + "Day-to-Day Test-Retest Reliability of EEG Profiles in Children With Autism Spectrum Disorder and Typical Development. Levin AR, Naples AJ, Scheffler AW, Webb SJ, Shic F, Sugar CA, Murias M, Bernier RA, Chawarska K, Dawson G, Faja S, Jeste S, Nelson CA, McPartland JC, Şentürk D. Front Integr Neurosci. 2020; 2020 Apr 30. PMID: 32425762.", + "The Presence of Another Person Influences Oscillatory Cortical Dynamics During Dual Brain EEG Recording. Rolison MJ, Naples AJ, Rutherford HJV, McPartland JC. Front Psychiatry. 2020; 2020 Apr 17. PMID: 32362842.", + "The Autism Biomarkers Consortium for Clinical Trials (ABC-CT): Scientific Context, Study Design, and Progress Toward Biomarker Qualification. McPartland JC, Bernier RA, Jeste SS, Dawson G, Nelson CA, Chawarska K, Earl R, Faja S, Johnson SP, Sikich L, Brandt CA, Dziura JD, Rozenblit L, Hellemann G, Levin AR, Murias M, Naples AJ, Platt ML, Sabatos-DeVito M, Shic F, Senturk D, Sugar CA, Webb SJ. Front Integr Neurosci. 2020; 2020 Apr 9. PMID: 32346363.", + "Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity. Hernandez LM, Lawrence KE, Padgaonkar NT, Inada M, Hoekstra JN, Lowe JK, Eilbott J, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, McPartland JC, Webb SJ, Pelphrey KA, Green SA, Geschwind DH, Bookheimer SY, Dapretto M. Transl Psychiatry. 2020 Mar 3; 2020 Mar 3. PMID: 32127526.", + "Biomarker Acquisition and Quality Control for Multi-Site Studies: The Autism Biomarkers Consortium for Clinical Trials. Webb SJ, Shic F, Murias M, Sugar CA, Naples AJ, Barney E, Borland H, Hellemann G, Johnson S, Kim M, Levin AR, Sabatos-DeVito M, Santhosh M, Senturk D, Dziura J, Bernier RA, Chawarska K, Dawson G, Faja S, Jeste S, McPartland J. Front Integr Neurosci. 2019; 2020 Feb 7. PMID: 32116579.", + "Real-Time Eye-to-Eye Contact Is Associated With Cross-Brain Neural Coupling in Angular Gyrus. Noah JA, Zhang X, Dravida S, Ono Y, Naples A, McPartland JC, Hirsch J. Front Hum Neurosci. 2020; 2020 Feb 6. PMID: 32116606.", + "Self-reported social impairments predict depressive disorder in adults with autism spectrum disorder. Day TC, McNaughton KA, Naples AJ, McPartland JC. Autism. 2020 Feb; 2019 Jun 25. PMID: 31238701.", + "Reply to Taylor et al.: Acknowledging the multidimensionality of autism when predicting social psychological skill. Gollwitzer A, Martel C, McPartland JC, Bargh JA. Proc Natl Acad Sci U S A. 2019 Dec 17; 2019 Dec 10. PMID: 31822624.", + "Autistic and alexithymic traits modulate distinct aspects of face perception. Desai A, Foss-Feig JH, Naples AJ, Coffman M, Trevisan DA, McPartland JC. Brain Cogn. 2019 Dec; 2019 Nov 14. PMID: 31734588.", + "A meta-analysis on the relationship between interoceptive awareness and alexithymia: Distinguishing interoceptive accuracy and sensibility. Trevisan DA, Altschuler MR, Bagdasarov A, Carlos C, Duan S, Hamo E, Kala S, McNair ML, Parker T, Stahl D, Winkelman T, Zhou M, McPartland JC. J Abnorm Psychol. 2019 Nov; 2019 Aug 5. PMID: 31380655.", + "Autism spectrum traits predict higher social psychological skill. Gollwitzer A, Martel C, McPartland JC, Bargh JA. Proc Natl Acad Sci U S A. 2019 Sep 24; 2019 Sep 9. PMID: 31501348.", + "Methodological considerations in the use of Noldus EthoVision XT video tracking of children with autism in multi-site studies. Sabatos-DeVito M, Murias M, Dawson G, Howell T, Yuan A, Marsan S, Bernier RA, Brandt CA, Chawarska K, Dzuira JD, Faja S, Jeste SS, Naples A, Nelson CA, Shic F, Sugar CA, Webb SJ, McPartland JC. Biol Psychol. 2019 Sep; 2019 Jun 1. PMID: 31163191.", + "Oxytocin Enhances the Neural Efficiency of Social Perception. Tillman R, Gordon I, Naples A, Rolison M, Leckman JF, Feldman R, Pelphrey KA, McPartland JC. Front Hum Neurosci. 2019; 2019 Mar 11. PMID: 30914935.", + "Reply to: Can the N170 Be Used as an Electrophysiological Biomarker Indexing Face Processing Difficulties in Autism Spectrum Disorder? Kang E, McPartland JC, Keifer CM, Foss-Feig JH, Levy EJ, Lerner MD. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Mar; 2018 Nov 1. PMID: 30391290.", + "The Potential of Repetitive Transcranial Magnetic Stimulation for Autism Spectrum Disorder: A Consensus Statement. Cole EJ, Enticott PG, Oberman LM, Gwynette MF, Casanova MF, Jackson SLJ, Jannati A, McPartland JC, Naples AJ, Puts NAJ. Biol Psychiatry. 2019 Feb 15; 2018 Aug 11. PMID: 30103951.", + "Yale Child Study Center 230 South Frontage Road New Haven, CT 06520", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Melia Lab", + "lab_url": "https://medicine.yale.edu/lab/melia/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Menon Lab", + "lab_url": "https://medicine.yale.edu/lab/menon/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/menon/publications", + "publications": null + }, + { + "lab_name": "mHealth Research and Innovation Lab", + "lab_url": "https://medicine.yale.edu/lab/mhri/", + "research_bio": "INFORMATION FOR Copy Link The mission of the Yale mHealth Research and Innovation (mHRI) Lab is to conduct cutting-edge, high-impact research on the development and implementation of digital health interventions, especially mHealth and eHealth, with the goal of improving health outcomes among LGBTQ populations. The mHRI Lab provides an inclusive space for training, research, and collaboration for students and faculty to foster growth in research on improving health outcomes in the areas of HIV treatment and prevention, mental health, and substance abuse. Copy Link Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Micevic Lab", + "lab_url": "https://medicine.yale.edu/lab/micevic/", + "research_bio": "INFORMATION FOR Our group is broadly interested in melanoma epigenetics and with specific interests in identifying epigenetic mechanisms regulating anti tumor immunity and functio. Using mouse models, single cell approaches, genetic perturbation tools and clinical tissues samples, the group aims to lay the foundation for the next-generation of cancer immunotherapies. Learn more about what we are working on in the lab. See published research by members of the lab. Meet the members of the lab. See contact information for the lab and learn about joining us. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Mishra Lab", + "lab_url": "https://medicine.yale.edu/lab/mishra/", + "research_bio": "INFORMATION FOR The Mishra Lab focuses on clinical research regarding stroke care, including acute intervention, prevention, and post-stroke recovery. It collaborates locally and globally, including with research groups within the United States Veterans Health Administration. Copy Link Recent advances in stroke management have led to a significant reduction in stroke mortality. However, we have not made much progress in preventing and treating one of its most common and serious complications, post-stroke epilepsy (PSE). Moreover, the level of scientific evidence to manage PSE patients remains low. Therefore, identifying the epileptogenic changes soon after stroke is critical. In service of this mission, we lead several national and international collaborative projects, including efforts through theInternational Post-Stroke Epilepsy Research Consortium (IPSERC). Copy Link We have a long-standing interest in reperfusion stroke therapy, perfusion imaging, and the management of behavioral manifestations of stroke. Collaborative scientific efforts to manage hemispatial neglect are underway. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/mishra/publications/", + "publications": [ + "Yale School of Medicine /", + "Neurology /", + "Selected Publications", + "Selected Abstracts", + "Conference Publications", + "People", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Selected Publications", + "Selected Abstracts", + "Conference Publications", + "People", + "", + "", + "", + "", + "", + "", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Mlynarczyk Lab", + "lab_url": "https://medicine.yale.edu/lab/mlynarczyk/", + "research_bio": "INFORMATION FOR At the interface between immunology, cancer and metabolism, the Mlynarczyk lab focuses on understanding competitive mechanisms of cell survival and expansion, through the lens of germinal centers and the cancers that originate from them. Exploring the Interface Between Immunology and Cancer Copy Link We are a new and welcoming lab and actively foster a dynamic, inclusive, and flourishing team environment, allowing everyone to grow as ascientist and person. Our goal is to carry out collaborative, rigorous and ground-breaking research towards developing targeted and rational treatments for patients who need it the most. Our lab is located on the 6thfloor at 300 George Street, connected to all other buildings of the School of Medicine. Our floor hosts a combination of early- mid- and well-established groups, forming a highly interactive, rich, and vibrant environment for trainees. The open lab space, shared lounge area and conference rooms provide opportunities for fruitful interactions. We use the newly renovated and fully equipped mouse facility as well as flow core facility on the 2ndfloor. We take part in multi-lab meetings, journal clubs, departmental RIP seminars across campus and benefit from the thriving research, education, and health-care communities as well as training programs atYale University. Copy Link We are always looking for self-motivated, smart and science-driven experimental and computational scientists to join our team. Please emailcoraline.mlynarczyk@yale.eduif you are interested (include cover letter and CV). Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Moeckel Lab", + "lab_url": "https://medicine.yale.edu/lab/moeckel/", + "research_bio": "INFORMATION FOR The Moeckel lab at Yale studies the molecular mechanisms of kidney cell regeneration and repair after ischemic/hypoxic and toxic injury. Moreover, the lab is also studying the role of intrinsic progenitor cells in cell injury repair after acute kidney injury (AKI). Another focus is to understand the molecular mechanisms that drive progression of chronic kidney disease after ischemic or toxic AKI. Please see ourResearchpage to read more about the research projects in our Lab. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/moeckel/publications/", + "publications": [ + "Yale School of Medicine /", + "Pathology /", + "Research", + "News", + "People", + "Publications", + "Contact Us", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "Contact Us", + "News", + "", + "", + "", + "", + "", + "", + "APOBEC-1 deletion enhances cisplatin-induced acute kidney injury. Guo X, Blanc V, Davidson NO, Velazquez H, Chen TM, Moledina DG, Moeckel GW, Safirstein RL, Desir GV. Sci Rep. 2023 Dec 14; 2023 Dec 14. PMID: 38097707.", + "Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis. Melchinger H, Calderon-Gutierrez F, Obeid W, Xu L, Shaw MM, Luciano RL, Kuperman M, Moeckel GW, Kashgarian M, Wilson FP, Parikh CR, Moledina DG. Clin J Am Soc Nephrol. 2022 Sep; 2022 Aug 10. PMID: 35948365.", + "Severe AKI in a Patient on Multiple Antimicrobial Agents for Leg Infection. Rehan A, Moeckel GW, Perazella MA. Kidney360. 2022 Feb 24; 2022 Feb 24. PMID: 35373119.", + "Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis. Moledina DG, Wilson FP, Kukova L, Obeid W, Luciano R, Kuperman M, Moeckel GW, Kashgarian M, Perazella MA, Cantley LG, Parikh CR. Nephrol Dial Transplant. 2021 Sep 27. PMID: 33125471.", + "Tubular Cell Dropout in Preimplantation Deceased Donor Biopsies as a Predictor of Delayed Graft Function. Avigan ZM, Singh N, Kliegel JA, Weiss M, Moeckel GW, Cantley LG. Transplant Direct. 2021 Jul; 2021 Jun 18. PMID: 34476295.", + "Response of the ENPP1-Deficient Skeletal Phenotype to Oral Phosphate Supplementation and/or Enzyme Replacement Therapy: Comparative Studies in Humans and Mice. Ferreira CR, Kavanagh D, Oheim R, Zimmerman K, Stürznickel J, Li X, Stabach P, Rettig RL, Calderone L, MacKichan C, Wang A, Hutchinson HA, Nelson T, Tommasini SM, von Kroge S, Fiedler IA, Lester ER, Moeckel GW, Busse B, Schinke T, Carpenter TO, Levine MA, Horowitz MC, Braddock DT. J Bone Miner Res. 2021 May; 2021 Feb 18. PMID: 33465815.", + "Collagenofibrotic glomerulopathy in a kidney transplant recipient: A first report. Jdiaa SS, Moeckel GW, Kfoury HM, Medawar WA, Abu-Alfa AK. Am J Transplant. 2021 May; 2020 Dec 23. PMID: 33206467.", + "PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus. Han X, Vesely MD, Yang W, Sanmamed MF, Badri T, Alawa J, López-Giráldez F, Gaule P, Lee SW, Zhang JP, Nie X, Nassar A, Boto A, Flies DB, Zheng L, Kim TK, Moeckel GW, McNiff JM, Chen L. Sci Transl Med. 2019 Dec 11. PMID: 31826980.", + "Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction pattern. Roy SF, Ko CJ, Moeckel GW, Mcniff JM. J Cutan Pathol. 2019 Oct; 2019 Jul 5. PMID: 31157457.", + "Development of a 2-dimensional atlas of the human kidney with imaging mass cytometry. Singh N, Avigan ZM, Kliegel JA, Shuch BM, Montgomery RR, Moeckel GW, Cantley LG. JCI Insight. 2019 Jun 20; 2019 Jun 20. PMID: 31217358.", + "Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. Moledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, Obeid W, Lin H, Kuperman M, Moeckel GW, Kashgarian M, Cantley LG, Parikh CR. JCI Insight. 2019 May 16; 2019 May 16. PMID: 31092735.", + "Regulated necrosis and failed repair in cisplatin-induced chronic kidney disease. Landau SI, Guo X, Velazquez H, Torres R, Olson E, Garcia-Milian R, Moeckel GW, Desir GV, Safirstein R. Kidney Int. 2019 Apr. PMID: 30904067.", + "Update on the Native Kidney Biopsy: Core Curriculum 2019. Luciano RL, Moeckel GW. Am J Kidney Dis. 2019 Mar; 2019 Jan 17. PMID: 30661724.", + "TREX1 Mutation Causing Autosomal Dominant Thrombotic Microangiopathy and CKD-A Novel Presentation. Gulati A, Bale AE, Dykas DJ, Bia MJ, Danovitch GM, Moeckel GW, Somlo S, Dahl NK. Am J Kidney Dis. 2018 Dec; 2018 Jun 22. PMID: 29941221.", + "Pathologic Perspectives on Acute Tubular Injury Assessment in the Kidney Biopsy. Moeckel GW. Semin Nephrol. 2018 Jan. PMID: 29291758.", + "Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI. Nakazawa D, Kumar SV, Marschner J, Desai J, Holderied A, Rath L, Kraft F, Lei Y, Fukasawa Y, Moeckel GW, Angelotti ML, Liapis H, Anders HJ. J Am Soc Nephrol. 2017 Jun; 2017 Jan 10. PMID: 28073931.", + "Isoforms of Spectrin and Ankyrin Reflect the Functional Topography of the Mouse Kidney. Stankewich MC, Moeckel GW, Ji L, Ardito T, Morrow JS. PLoS One. 2016; 2016 Jan 4. PMID: 26727517.", + "Antiphospholipid Antibody Syndrome: Raised Intracranial Pressure Without Cerebral Venous Sinus Thrombosis. Rudich DS, Yun SH, Liebling A, Silbert JE, Moeckel GW, Lesser RL. J Neuroophthalmol. 2015 Dec. PMID: 26049680.", + "GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury. Huen SC, Huynh L, Marlier A, Lee Y, Moeckel GW, Cantley LG. J Am Soc Nephrol. 2015 Jun; 2014 Nov 11. PMID: 25388222.", + "Quantification and localization of M2 macrophages in human kidneys with acute tubular injury. Palmer MB, Vichot AA, Cantley LG, Moeckel GW. Int J Nephrol Renovasc Dis. 2014; 2014 Nov 7. PMID: 25404860.", + "Role of medullary progenitor cells in epithelial cell migration and proliferation. Chen D, Chen Z, Zhang Y, Park C, Al-Omari A, Moeckel GW. Am J Physiol Renal Physiol. 2014 Jul 1; 2014 May 7. PMID: 24808539.", + "Early B-cell factor 1 is an essential transcription factor for postnatal glomerular maturation. Fretz JA, Nelson T, Velazquez H, Xi Y, Moeckel GW, Horowitz MC. Kidney Int. 2014 May; 2013 Oct 30. PMID: 24172684.", + "Cytomegalovirus glomerulopathy and cytomegalovirus interstitial nephritis on sequential transplant kidney biopsies. Vichot AA, Formica RN Jr, Moeckel GW. Am J Kidney Dis. 2014 Mar; 2013 Oct 25. PMID: 24568687.", + "Hypertonic stress and cell death. Focus on \"Multiple cell death pathways are independently activated by lethal hypertonicity in renal epithelial cells\". Moeckel GW. Am J Physiol Cell Physiol. 2013 Nov 15; 2013 Sep 4. PMID: 24005043.", + "Aldosterone stimulates fibronectin synthesis in renal fibroblasts through mineralocorticoid receptor-dependent and independent mechanisms. Chen D, Chen Z, Park C, Centrella M, McCarthy T, Chen L, Al-Omari A, Moeckel GW. Gene. 2013 Nov 15; 2013 Aug 30. PMID: 23994292.", + "NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy. Knauf F, Asplin JR, Granja I, Schmidt IM, Moeckel GW, David RJ, Flavell RA, Aronson PS. Kidney Int. 2013 Nov; 2013 Jun 5. PMID: 23739234.", + "Warfarin-related nephropathy in a patient with mild IgA nephropathy on dabigatran and aspirin. Moeckel GW, Luciano RL, Brewster UC. Clin Kidney J. 2013 Oct; 2013 Sep 10. PMID: 26120444.", + "Macrophage-specific deletion of transforming growth factor-β1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury. Huen SC, Moeckel GW, Cantley LG. Am J Physiol Renal Physiol. 2013 Aug 15; 2013 Jun 12. PMID: 23761668.", + "Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome. Lemaire M, Frémeaux-Bacchi V, Schaefer F, Choi M, Tang WH, Le Quintrec M, Fakhouri F, Taque S, Nobili F, Martinez F, Ji W, Overton JD, Mane SM, Nürnberg G, Altmüller J, Thiele H, Morin D, Deschenes G, Baudouin V, Llanas B, Collard L, Majid MA, Simkova E, Nürnberg P, Rioux-Leclerc N, Moeckel GW, Gubler MC, Hwa J, Loirat C, Lifton RP. Nat Genet. 2013 May; 2013 Mar 31. PMID: 23542698.", + "Chitinase-like protein Brp-39/YKL-40 modulates the renal response to ischemic injury and predicts delayed allograft function. Schmidt IM, Hall IE, Kale S, Lee S, He CH, Lee Y, Chupp GL, Moeckel GW, Lee CG, Elias JA, Parikh CR, Cantley LG. J Am Soc Nephrol. 2013 Feb; 2013 Jan 4. PMID: 23291472.", + "Inorganic phosphate stimulates fibronectin expression in renal fibroblasts. Chen Z, Chen D, McCarthy TL, Centrella M, Zhang Y, Moeckel GW. Cell Physiol Biochem. 2012; 2012 Jun 18. PMID: 22759963.", + "Resolution of proteinuria in a patient with focal segmental glomerulosclerosis following BiPAP initiation for obesity hypoventilation syndrome. Hall IE, Kashgarian M, Moeckel GW, Dahl NK. Clin Nephrol. 2012 Jan. PMID: 22185970.", + "Proteinuria and glomerular injury associated with the anti-angiogenesis drug Vargatef™. Manjunath V, Moeckel GW, Mahnensmith R, Perazella MA. NDT Plus. 2011 Dec; 2011 Jun 1. PMID: 25984216.", + "Podocyte vascular endothelial growth factor (Vegf₁₆₄) overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetes. Veron D, Bertuccio CA, Marlier A, Reidy K, Garcia AM, Jimenez J, Velazquez H, Kashgarian M, Moeckel GW, Tufro A. Diabetologia. 2011 May; 2011 Feb 12. PMID: 21318407.", + "SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function. Jurczak MJ, Lee HY, Birkenfeld AL, Jornayvaz FR, Frederick DW, Pongratz RL, Zhao X, Moeckel GW, Samuel VT, Whaley JM, Shulman GI, Kibbey RG. Diabetes. 2011 Mar. PMID: 21357472.", + "Nephrotoxicity from chemotherapeutic agents: clinical manifestations, pathobiology, and prevention/therapy. Perazella MA, Moeckel GW. Semin Nephrol. 2010 Nov. PMID: 21146122.", + "Hematuria and decreased kidney function as initial signs of acute B-cell lymphoblastic leukemia. Seo-Mayer P, Kenney B, McNamara J, Stein J, Moeckel GW. Am J Kidney Dis. 2010 Nov. PMID: 20599308.", + "Hypertonicity-induced mitochondrial membrane permeability in renal medullary interstitial cells: protective role of osmolytes. Zhang L, Chen D, Chen Z, Moeckel GW. Cell Physiol Biochem. 2010; 2010 May 18. PMID: 20511721.", + "Deletion of the Met receptor in the collecting duct decreases renal repair following ureteral obstruction. Ma H, Saenko M, Opuko A, Togawa A, Soda K, Marlier A, Moeckel GW, Cantley LG, Ishibe S. Kidney Int. 2009 Oct; 2009 Aug 12. PMID: 19675527.", + "310 Cedar Street PO Box 208023 New Haven, CT 06520-8023", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Moliterno Lab", + "lab_url": "https://medicine.yale.edu/lab/moliterno/", + "research_bio": "INFORMATION FOR Under the leadership of Dr. Jennifer Moliterno, the Section Chief of Neurosurgical Oncology in the Yale Department of Neurosurgery, the Yale Primary Brain Tumor Surgery Program is the busiest in Connecticut, as we continue to perform the highest volume of brain tumor surgeries each year. We are privileged to do so as part of an academic community of impressive scientific interest and work in brain tumors. Over the past several years, an increasing number of laboratories across our campus have benefited from our high volume of primary brain tumor specimens from these surgical procedures. Additionally, we have developed one of the largest prospective databases with detailed clinical and genomic data of primary brain tumors. The Yale Primary Brain Tumor Surgery Program is dedicated to supporting brain tumor research and has spearheaded this biospecimen oversight. The Moliterno Lab has been founded as a centralized tumor bank, with primary brain tumor specimens being established as sphere cultures and patient derived xenografts. Our focus is then on clinical observation-derived research, as well as that generated from data mining. Our tissue bank is also then available for the collaborative study of brain tumor pathology. Diseases of interest include all types of primary brain tumors, most commonly gliomas, meningiomas and schwannomas. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/moliterno/selected-manuscripts", + "publications": null + }, + { + "lab_name": "Montalvo-Ortiz Lab", + "lab_url": "https://medicine.yale.edu/lab/montalvo-ortiz/", + "research_bio": "INFORMATION FOR Copy Link To advance the understanding of the genetic and epigenetic architecture as a way to dissect the underlying mechanisms of the complex interplay between genes and environment that contributes to an increased risk for psychiatric disorders. We are committed to scientific excellence, work ethic, creativity, innovation, and societal relevance of our findings. We foster an environment that that promotes collaboration, networking, career development, mentorship, and sponsorship. Our ultimate goal is to support and train the next generation of scientists, equipping them to carry forward our mission and lead impactful research to uncover the biological foundations of psychiatric disorders. Copy Link Our group is focused on understanding the genomic and epigenomic architecture of neuropsychiatric disorders. Copy Link We use cutting-edge approaches to dissect the epigenomic landscape of psychiatric disorders in human peripheral and postmortem brain tissue. We focused on studying substance use disorders, post-traumatic stress disorder, and major depression, and related traits.. Multi-omics datasets (genomics, methylomics, transcriptomics, proteomics) are investigated to better understand the underlying mechanisms and identify predictors or biomarkers for these disorders. Copy Link We also seek to advance psychiatric genomics in Latin American populations based on our work in the Latin American Genomics Consortium (LAGC) and Psychiatric Genomics Consortium (PGC). The main goals include 1) increasing sample size of genomic studies by meta-analysis, 2) recruitment and genotyping of new samples, 3) methods development and 4) education and training. Our work is funded by the National Institute of Health and the Department of Veteran’s Affairs. Copy Link National Institutes of Health U.S. Department of Veterans Affairs Copy Link Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Morris-Cosgrove Lab", + "lab_url": "https://medicine.yale.edu/lab/morris/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Morrow Lab", + "lab_url": "https://medicine.yale.edu/lab/morrow/", + "research_bio": "INFORMATION FOR Copy Link In the Morrow Lab, our focus of research is the spectrin membrane cytoskeleton and its evidently pivotal role in the process of organizing specialized membrane-surface domains that are central to the integrated function of all multicellular organisms. Among the questions we research and discuss are: How is it that cells are so elegant in their spatial design? How do tissues and cells achieve specialized or polarized domains? How does the cellular scaffold comprised of a protein called spectrin contribute to forming and maintaining order within membranes? And in terms of practical relevance to disease processes: How does the loss of spectrin function contribute to red blood cell disorders such as hereditary hemolytic anemia or diseases of the central nervous system including cerebellar ataxias and intellectual disability? Please visit ourResearchpage to read more about the research in our Lab. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/morrow/publications/", + "publications": null + }, + { + "lab_name": "Mothes Lab", + "lab_url": "https://medicine.yale.edu/lab/mothes/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Mu Lab", + "lab_url": "https://medicine.yale.edu/lab/mu/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Multi-modal Imaging, Neuroinformatics, & Data Science (MINDS) Laboratory", + "lab_url": "https://medicine.yale.edu/lab/scheinost/", + "research_bio": "INFORMATION FOR Our research center is located in The Anlyan Center (TAC) at Yale University in New Haven, CT. Our research group comprises academics and clinicians spanning physics, psychiatry, neuroscience, and biology, but the focus of the group is on new functional magnetic resonance imaging (fMRI) methods, primarily encompassing functional connectivity, multiscale analysis, machine learning, statistical benchmarking, and software development. Active topics of investigation include: individualized parcellation, connectivity-based predictive modeling (CPM), methodology reproducibility, and web-based software development. Copy Link Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Müschen Lab", + "lab_url": "https://medicine.yale.edu/lab/muschen/", + "research_bio": "INFORMATION FOR Copy Link Less than 1 in 2,000 cells in the human body are B-cells. Once activated, B-cells divide at a faster rate than any other cell type and produce antibodies to neutralize foreign pathogens. Unlike other cell types, B-cells undergo multiple rounds of somatic gene recombination and hypermutation of immunoglobulin genes to evolve antibodies that bind to antigen with high affinity. Hence, adaptive immune protection by B-cells comes with an approximately 300-fold increased risk of malignant transformation compared to other cell types.B-cell leukemia/lymphomarepresent the most frequent type of cancer in children (31%) and account for 10% of all cancers in adults. To prevent the production of harmful autoantibodies and autoimmune disease, autoreactive B-cells and pre-malignant clones are eliminated by a process termed negative selection. Despite strict and rigorous negative selection, B-cells frequently give rise to autoimmune diseases and B-cell malignancies such as leukemia and lymphoma. Since humans can live without B-cells for extended periods of time, the Müschen laboratory systematically investigated lineage-specific vulnerabilities that are common in B-cell leukemia/lymphoma but not any other cell type. Contrary to established dogma, these mechanisms are not only active in preventing autoimmune disease but also represent a novel class of therapeutic oncogenic targets in malignant B-cell tumors. Over the past five years, the Müschen Laboratory established innovative conceptual frameworks for the understanding of B-cell signaling mechanisms and negative selection, some of which are summarized below:", + "publications_page": "https://medicine.yale.edu/lab/muschen/publications", + "publications": null + }, + { + "lab_name": "Muzumdar Lab", + "lab_url": "https://medicine.yale.edu/lab/muzumdar/", + "research_bio": "INFORMATION FOR Our laboratory is interested in understanding the mechanisms by which genetic, environmental, and host factors contribute to cancer initiation, progression, and maintenance. Leveraging a combination of sophisticated genetically-engineered cell and animal models, we seek to define the molecular basis for the tumor cell and host adaptations that drive cancer progression. Furthermore, we usegenetic and pharmacologic approachescombined with novelnanoparticle-based delivery methodsto augment or impede these adaptations and determine the consequences on cancer development in these models. The ultimate goal of our research is to identify new strategies for cancer prevention and treatment. Having opened our doors in late 2017, our lab is actively seeking postdoctoral fellows, graduate students, and postgraduate associates to join us in our research journey. We invite you to read more about our researchon this websiteand on Twitter at@MuzumdarLab. Also, check out our most recent work identifying a local pancreatic endocrine-exocrine signaling axis as a driver of obesity-associated pancreatic ductal adenocarcinoma, published in the journalCelland featured in Research Highlights byNature Reviews CancerandCancer Discovery.", + "publications_page": "https://medicine.yale.edu/lab/muzumdar/publications", + "publications": [ + "Yale School of Medicine /", + "Genetics /", + "Research Targeting KRAS in pancreatic cancer Deciphering the mechanistic link between obesity and pancreatic cancer Tracing tumor progression in KRAS-driven cancers", + "Targeting KRAS in pancreatic cancer", + "Deciphering the mechanistic link between obesity and pancreatic cancer", + "Tracing tumor progression in KRAS-driven cancers", + "Contact Us", + "Lab Members", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Lab Members", + "Publications", + "News", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Tracing the evolution of single-cell 3D genomes in Kras-driven cancers Liu M, Jin S, Agabiti S, Jensen T , Yang T, Radda J, Ruiz C, Baldissera G, Rajaei M, Li F , Townsend J , Muzumdar M , Wang S . Tracing the evolution of single-cell 3D genomes in Kras-driven cancers . Nature Genetics 2025, 1-13. PMID: 40825871 , DOI: 10.1038/s41588-025-02297-w . Peer-Reviewed Original Research Citations Altmetric Concepts Cell-to-cell heterogeneity Genome-wide chromatin Genome compaction Genome architecture Genomic structure Genome mapping Genome regulation Lung adenocarcinoma Dependent genes KRAS-driven cancers Genome Mouse lung adenocarcinoma Cancer progression Early tumor progression Single cells Cancer state Genes Pancreatic ductal adenocarcinoma Invasive tumors Therapeutic biomarkers Ductal adenocarcinoma Tumor progression Compartmental changes Chromatin Cancer", + "Direct genetic transformation bypasses tumor-associated DNA methylation alterations Hetzel S, Hodis E, Torlai Triglia E, Kovacsovics A, Steinmann K, Gnirke A, Cui M, McQuaid D, Weigert R, Pohl G, Muzumdar M , Leyvraz S, Keilholz U, Yaspo M, Regev A, Kretzmer H, Smith Z , Meissner A. Direct genetic transformation bypasses tumor-associated DNA methylation alterations . Genome Biology 2025, 26: 212. PMID: 40676699 , PMCID: PMC12273271 , DOI: 10.1186/s13059-025-03650-2 . Peer-Reviewed Original Research MeSH Keywords and Concepts MeSH Keywords Animals Cell Transformation, Neoplastic DNA Methylation Epigenesis, Genetic Gene Expression Regulation, Neoplastic Humans Mice Neoplasms Promoter Regions, Genetic Concepts De novo methylation Epigenetic aspects DNA methylation landscape DNA methylation alterations DNA methylation levels Methylation landscape Mutant cells Promoter sequences Extensive proliferation in vitro Methylation alterations Cellular transformation Methylation levels Human cells Genetic transformation Global change Healthy human cells Clinical samples Animal systems ConclusionsOur results Molecular reference Proliferation in vitro Cells Mouse model Tumor model DNA", + "Keep It Moving: Physical Activity in the Prevention of Obesity-Driven Pancreatic Cancer. Sogunro A, Muzumdar M . Keep It Moving: Physical Activity in the Prevention of Obesity-Driven Pancreatic Cancer. Cancer Research 2024, 84: 2935-2937. PMID: 39279380 , DOI: 10.1158/0008-5472.can-24-1474 . Peer-Reviewed Original Research Citations MeSH Keywords and Concepts MeSH Keywords Animals Carcinoma, Pancreatic Ductal Diet, High-Fat Disease Models, Animal Exercise Humans Mice Obesity Pancreatic Neoplasms Physical Conditioning, Animal Tumor Microenvironment Concepts Pancreatic ductal adenocarcinoma Tumor microenvironment Antitumor effect Pancreatic cancer Obese mice Physical activity Advanced tumor growth Systemic cytokine production Myeloid cell infiltration Pancreatic ductal adenocarcinoma development Effect of obesity High-fat diet-induced obesity Diet-induced obesity Syngeneic allografts Advanced tumors Protumorigenic effects Lean mice White adipose tissue Cell infiltration Ductal adenocarcinoma Obesity-associated Tumor growth Cytokine production Impact of physical activity Inflammatory cytokines", + "Perioperative Modified FOLFIRINOX for Resectable Pancreatic Cancer Cecchini M , Salem R, Robert M , Czerniak S, Blaha O , Zelterman D , Rajaei M, Townsend J, Cai G, Chowdhury S, Yugawa D, Tseng R, Arbelaez C, Jiao J, Shroyer K, Thumar J , Kortmansky J , Zaheer W, Fischbach N , Persico J, Stein S, Khan S, Cha C, Billingsley K , Kunstman J, Johung K , Wiess C, Muzumdar M , Spickard E, Aushev V, Laliotis G, Jurdi A, Liu M, Escobar-Hoyos L , Lacy J. Perioperative Modified FOLFIRINOX for Resectable Pancreatic Cancer . JAMA Oncology 2024, 10: 1027-1035. PMID: 38900452 , PMCID: PMC11190830 , DOI: 10.1001/jamaoncol.2024.1575 . Peer-Reviewed Original Research Citations Altmetric Concepts Progression-free survival Pancreatic ductal adenocarcinoma Overall survival CtDNA levels Phase 2 nonrandomized controlled trial Analysis of circulating tumor DNA Median progression-free survival Resectable pancreatic ductal adenocarcinoma Controlled Trials Assess surgical candidacy Baseline ctDNA level Modified 5-fluorouracil Resectable pancreatic cancer Pancreatic protocol computed tomography Associated with recurrence Tumor molecular features Aggressive malignant tumor Kaplan-Meier estimates Randomized clinical trials Standard of care CtDNA-positive Preoperative cycles Nonrandomized controlled trials Unresectable disease Modified FOLFIRINOX", + "994 NANOSTRING GEOMX SPATIAL TRANSCRIPTOMIC ANALYSIS OF PANCREATIC ISLETS IN DIABETIC AND NONDIABETIC PANCREATIC CANCER PATIENTS REVEALS BETA CELL DEDIFFERENTIATION ASSOCIATED WITH ER STRESS PATHWAYS AND ALTERED LIPID METABOLISM Waldron R, Lugea A, Yong J, Muranaka H, Che M, Ramanujan V, Muzumdar M , Kaufman R, Pandol S. 994 NANOSTRING GEOMX SPATIAL TRANSCRIPTOMIC ANALYSIS OF PANCREATIC ISLETS IN DIABETIC AND NONDIABETIC PANCREATIC CANCER PATIENTS REVEALS BETA CELL DEDIFFERENTIATION ASSOCIATED WITH ER STRESS PATHWAYS AND ALTERED LIPID METABOLISM . Gastroenterology 2024, 166: s-242. DOI: 10.1016/s0016-5085(24)01042-4 . Peer-Reviewed Original Research Concepts ER stress pathway Transcriptome analysis Stress pathways Spatial transcriptomic analysis Pancreatic islets", + "Imaging nanoscale-spatial oligomeric organization of membrane proteins directly from native membranes at single-molecule resolution Walker G, Brown C, Ge X, Kumar S, Muzumdar M , Gupta K , Bhattacharyya M . Imaging nanoscale-spatial oligomeric organization of membrane proteins directly from native membranes at single-molecule resolution . Biophysical Journal 2024, 123: 348a. DOI: 10.1016/j.bpj.2023.11.2115 . Peer-Reviewed Original Research Concepts Single-molecule resolution Membrane proteins Oligomeric organization Native membranes", + "Oligomeric organization of membrane proteins from native membranes at nanoscale spatial and single-molecule resolution Walker G, Brown C, Ge X, Kumar S, Muzumdar M , Gupta K , Bhattacharyya M . Oligomeric organization of membrane proteins from native membranes at nanoscale spatial and single-molecule resolution . Nature Nanotechnology 2023, 19: 85-94. PMID: 38012273 , PMCID: PMC10981947 , DOI: 10.1038/s41565-023-01547-4 . Peer-Reviewed Original Research Citations Altmetric Concepts Membrane proteins Native membranes Oligomeric organization Diverse membrane proteins Membrane protein biology Native cell membranes Target membrane proteins Native membrane environment Single-molecule resolution Single-molecule platform Receptor tyrosine kinases Oligomeric distribution Native nanodiscs Oligomerization status Protein biology Small GTPase Growth factor binding Membrane environment Oligomeric assemblies Tyrosine kinase Critical regulator Oncogenic mutations Cell membrane Protein Membrane", + "Decoding the obesity–cancer connection: lessons from preclinical models of pancreatic adenocarcinoma Ruiz C, Garcia C, Jacox J , Lawres L , Muzumdar M . Decoding the obesity–cancer connection: lessons from preclinical models of pancreatic adenocarcinoma . Life Science Alliance 2023, 6: e202302228. PMID: 37648285 , PMCID: PMC10474221 , DOI: 10.26508/lsa.202302228 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Adenocarcinoma Carcinogenesis Cell Transformation, Neoplastic Humans Obesity Pancreatic Neoplasms Concepts Pancreatic adenocarcinoma Preclinical models Obesity-cancer connection Obesity-associated cancers Microbial dysbiosis Hormone dysregulation Early progression Risk factors Worldwide prevalence Pancreatic tumorigenesis Obesity Preclinical modeling Cancer types Cancer development Tumor cells Adenocarcinoma Tumor initiation Cancer Metabolic state Cellular metabolism Novel strategy Dysbiosis Inflammation Therapy Prevalence", + "Physical Restraints in Advanced Illness #462 McQuaid D , Roberts A, Lescott S, Prsic E. Physical Restraints in Advanced Illness #462 . Journal Of Palliative Medicine 2023, 26: 1150-1152. DOI: 10.1089/jpm.2023.0174 . Peer-Reviewed Original Research", + "Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433-448. Mastracci T, Apte M, Amundadottir L, Alvarsson A, Artandi S, Bellin M, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, Ouaamari A, Gaulton K, Geisz A, Goodarzi M, Hara M, Hull-Meichle R, Kleger A, Klein A, Kopp J, Kulkarni R, Muzumdar M , Naren A, Oakes S, Olesen S, Phelps E, Powers A, Stabler C, Tirkes T, Whitcomb D, Yadav D, Yong J, Zaghloul N, Pandol S, Sander M. Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433-448. Diabetes 2023, 72: 1173. PMID: 37116182 , PMCID: PMC10382644 , DOI: 10.2337/db23-er08 . Peer-Reviewed Original Research Altmetric Concepts Endocrine compartment Integrated physiology Physiology Compartments", + "Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Mastracci T, Apte M, Amundadottir L, Alvarsson A, Artandi S, Bellin M, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton K, Geisz A, Goodarzi M, Hara M, Hull-Meichle R, Kleger A, Klein A, Kopp J, Kulkarni R, Muzumdar M , Naren A, Oakes S, Olesen S, Phelps E, Powers A, Stabler C, Tirkes T, Whitcomb D, Yadav D, Yong J, Zaghloul N, Pandol S, Sander M. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023, 72: 433-448. PMID: 36940317 , PMCID: PMC10033248 , DOI: 10.2337/db22-0942 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Diabetes Mellitus Humans Islets of Langerhans Pancreas Pancreas, Exocrine Pancreatic Diseases Concepts Pancreatic disease Endocrine compartment Exocrine disease Basic science investigators Exocrine disorder Integrated physiology Metabolic influences Exocrine pancreas Disease Disease mechanisms Normal physiology National Institute Pancreas anatomy Genetic drivers Pancreas Multiple presentations Exocrine Current knowledge", + "Oligomeric distribution of membrane proteins in native-membrane environment at nanoscale spatial and single-molecule resolution Walker G, Brown C, Ge X, Gupta K , Muzumdar M , Bhattacharyya M . Oligomeric distribution of membrane proteins in native-membrane environment at nanoscale spatial and single-molecule resolution . Biophysical Journal 2023, 122: 457a. DOI: 10.1016/j.bpj.2022.11.2457 . Peer-Reviewed Original Research Concepts Native membrane environment Single-molecule resolution Membrane proteins Oligomeric distribution Protein Nanoscale", + "Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases Mastracci T, Apte M, Amundadottir L, Alvarsson A, Artandi S, Bellin M, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, Ouaamari A, Gaulton K, Geisz A, Goodarzi M, Hara M, Hull-Meichle R, Kleger A, Klein A, Kopp J, Kulkarni R, Muzumdar M , Naren A, Oakes S, Olesen S, Phelps E, Powers A, Stabler C, Tirkes T, Whitcomb D, Yadav D, Yong J, Zaghloul N, Sander M, Pandol S. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases . Pancreas 2022, 51: 1061-1073. PMID: 37078927 , PMCID: PMC10328394 , DOI: 10.1097/mpa.0000000000002170 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Diabetes Mellitus Humans Islets of Langerhans Pancreas Pancreas, Exocrine Pancreatic Diseases Concepts Pancreatic disease Endocrine compartment Exocrine disease Basic science investigators Exocrine disorder Integrated physiology Metabolic influences Disease Exocrine pancreas Disease mechanisms Normal physiology National Institute Pancreas anatomy Genetic drivers Pancreas Exocrine Multiple presentations", + "IRF8 as a Novel Marker to Differentiate Between CD30-Positive Large Cell Lymphomas McQuaid DC , Katz SG , Xu ML . IRF8 as a Novel Marker to Differentiate Between CD30-Positive Large Cell Lymphomas . American Journal Of Clinical Pathology 2022, 158: 173-176. PMID: 35460405 , PMCID: PMC10664184 , DOI: 10.1093/ajcp/aqac044 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords Diagnosis, Differential Hodgkin Disease Humans Interferon Regulatory Factors Ki-1 Antigen Lymphoma, Large-Cell, Anaplastic Receptor Protein-Tyrosine Kinases Retrospective Studies", + "Global assessment of IRF8 as a novel cancer biomarker McQuaid DC , Panse G , Wang WL, Pinkus GS, Katz SG , Xu ML . Global assessment of IRF8 as a novel cancer biomarker . Human Pathology 2022, 122: 1-10. PMID: 35085599 , PMCID: PMC10621657 , DOI: 10.1016/j.humpath.2022.01.004 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Biomarkers, Tumor Humans Interferon Regulatory Factors Neoplasms Retrospective Studies Sarcoma Concepts Blastic plasmacytoid dendritic cell neoplasm Interferon regulatory factor 8 Myeloid sarcoma Differential diagnosis Plasmacytoid dendritic cell neoplasm Desmoplastic small round cell tumor Small round cell tumor Triple-negative breast cancer Strong uniform expression Dendritic cell neoplasm Broad differential diagnosis Negative breast cancer Round cell tumor Absence of CD34 IHC expression patterns Acute monocytic leukemia Novel immunohistochemical marker Types of cancer Regulatory factor 8 Cancer Genome Atlas Novel cancer biomarkers Retrospective study Synovial sarcoma Cell tumors Pleomorphic sarcoma", + "Establishment of a novel mesenchymal stem cell-based regimen for chronic myeloid leukemia differentiation therapy Zuo S, Sun L, Wang Y, Chen B, Wang J, Ge X , Lu Y, Yang N, Shen P. Establishment of a novel mesenchymal stem cell-based regimen for chronic myeloid leukemia differentiation therapy . Cell Death & Disease 2021, 12: 208. PMID: 33627636 , PMCID: PMC7904926 , DOI: 10.1038/s41419-021-03499-w . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Benzoates Cell Lineage Coculture Techniques Gene Expression Regulation, Leukemic Humans Hydrazines Janus Kinases K562 Cells Leukemia, Myelogenous, Chronic, BCR-ABL Positive Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells Mice, Nude Mitogen-Activated Protein Kinases Pyrazoles Receptors, Thrombopoietin Signal Transduction STAT Transcription Factors Thrombopoiesis Umbilical Cord Xenograft Model Antitumor Assays Concepts Chronic myeloid leukemia Tyrosine kinase inhibitors Progression of CML CML cells UC-MSCs Differentiation therapy Current tyrosine kinase inhibitors Therapeutic potential Mesenchymal stem cell treatment Acute promyelocytic leukemia (APL) treatment Immature white blood cells Severe adverse effects White blood cells Trans retinoic acid Stem cell treatment Stem/progenitor cells Complete remission Treatment regimen Tumor burden CML patients Cure rate MAPK signaling pathways Peripheral blood Hematopoietic stem/progenitor cells Myeloid leukemia", + "5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING Tian J, Zhang D, Kurbatov V , Wang Q, Wang Y, Fang D, Wu L , Bosenberg M , Muzumdar MD , Khan S , Lu Q, Yan Q , Lu J . 5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING . The EMBO Journal 2021, 40: embj2020106065. PMID: 33615517 , PMCID: PMC8013832 , DOI: 10.15252/embj.2020106065 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Antineoplastic Agents Cell Line, Tumor Cells, Cultured Drug Resistance, Neoplasm Female Fluorouracil Humans Interferon Type I Membrane Proteins Mice Mice, Inbred BALB C Mice, Inbred C57BL Nucleotidyltransferases T-Lymphocytes Tumor Microenvironment Concepts Anti-tumor immunity Tumor burden Subsequent type I interferon production High STING expression Intratumoral T cells T-cell depletion Type I interferon production I interferon production Loss of STING Immunocompetent hosts Colorectal specimens T cells STING expression Better survival High dose Therapeutic effectiveness Human colorectal specimens Melanoma tumors Interferon production Chemotherapeutic drugs Murine colon Immunity Efficacy Stings Colon", + "Cryptic Cachexia Odio CD, O'Brien CR, Jacox J , Jain D, Lee AI. Cryptic Cachexia . New England Journal Of Medicine 2020, 383: 68-74. PMID: 32609985 , DOI: 10.1056/nejmcps1817531 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Adenocarcinoma Anti-Bacterial Agents Ascites Cachexia Colostomy Diagnosis, Differential Duodenum Humans Male Middle Aged Radiography, Thoracic Rectal Neoplasms Recurrence Tomography, X-Ray Computed Weight Loss Whipple Disease Concepts Rectal adenocarcinoma Weight loss Cachexia Colostomy Adenocarcinoma", + "Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma Chung KM, Singh J, Lawres L , Dorans KJ, Garcia C, Burkhardt DB, Robbins R, Bhutkar A, Cardone R, Zhao X, Babic A, Vayrynen SA, Dias Costa A, Nowak JA, Chang DT, Dunne RF, Hezel AF, Koong AC, Wilhelm JJ, Bellin MD, Nylander V, Gloyn AL, McCarthy MI, Kibbey RG , Krishnaswamy S , Wolpin BM, Jacks T, Fuchs CS , Muzumdar MD . Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma . Cell 2020, 181: 832-847.e18. PMID: 32304665 , PMCID: PMC7266008 , DOI: 10.1016/j.cell.2020.03.062 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Carcinogenesis Carcinoma, Pancreatic Ductal Cell Line Cell Line, Tumor Cell Transformation, Neoplastic Disease Models, Animal Disease Progression Endocrine Cells Exocrine Glands Female Gene Expression Regulation, Neoplastic Humans Male Mice Mice, Inbred C57BL Mutation Obesity Pancreatic Neoplasms Signal Transduction Tumor Microenvironment Concepts Pancreatic ductal adenocarcinoma PDAC progression Ductal adenocarcinoma Major modifiable risk factor Modifiable risk factors Beta cell expression Obesity-associated changes Autochthonous mouse model Pancreatic ductal tumorigenesis Driver gene mutations Peptide hormone cholecystokinin Risk factors PDAC development Mouse model Obesity Hormone cholecystokinin Oncogenic Kras Cell expression Tumor microenvironment Dietary induction Cancer development Gene mutations Reversible role Murine samples Progression", + "Identification of DHODH as a therapeutic target in small cell lung cancer Li L, Ng SR, Colón CI, Drapkin BJ, Hsu PP, Li Z, Nabel CS, Lewis CA, Romero R, Mercer KL, Bhutkar A, Phat S, Myers DT, Muzumdar MD , Westcott PMK, Beytagh MC, Farago AF, Vander Heiden MG, Dyson NJ, Jacks T. Identification of DHODH as a therapeutic target in small cell lung cancer . Science Translational Medicine 2019, 11 PMID: 31694929 , PMCID: PMC7401885 , DOI: 10.1126/scitranslmed.aaw7852 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Adenocarcinoma Animals Biphenyl Compounds Carcinoma, Pancreatic Ductal Cell Line, Tumor DCMP Deaminase Dihydroorotate Dehydrogenase Disease Progression Enzyme Inhibitors Humans Lung Neoplasms Mice Molecular Targeted Therapy Oxidoreductases Acting on CH-CH Group Donors Pancreatic Neoplasms Pyrimidines Small Cell Lung Carcinoma Survival Analysis Xenograft Model Antitumor Assays Concepts Small cell lung cancer Cell lung cancer Pancreatic ductal adenocarcinoma Lung cancer Lung adenocarcinoma Mouse model SCLC cells Therapeutic target Human patient-derived xenograft models Aggressive lung cancer subtype Patient-derived xenograft models Lung cancer subtypes Autochthonous mouse model Potential therapeutic target SCLC tumor growth Genetic driver events Treatment landscape Poor prognosis Ductal adenocarcinoma Xenograft model Cancer subtypes Tumor growth Pharmacological inhibition Dihydroorotate dehydrogenase Genetic vulnerability", + "Treatment of obesity-related inflammation with a novel synthetic pentacyclic oleanane triterpenoids via modulation of macrophage polarization Yang N, Tang Q, Qin W, Li Z, Wang D, Zhang W, Cao X, Lu Y, Ge X , Sun H, Shen P. Treatment of obesity-related inflammation with a novel synthetic pentacyclic oleanane triterpenoids via modulation of macrophage polarization . EBioMedicine 2019, 45: 473-486. PMID: 31285187 , PMCID: PMC6642413 , DOI: 10.1016/j.ebiom.2019.06.053 . Peer-Reviewed Original Research Citations MeSH Keywords and Concepts MeSH Keywords Adipose Tissue Animals Cell Polarity China Diet, High-Fat Disease Models, Animal Humans Inflammation Macrophages Male Mice Mice, Obese Obesity Oleanolic Acid Pentacyclic Triterpenes Signal Transduction Concepts Macrophage polarization Adipose inflammation Obese mice Metabolic disorders Obesity-related metabolic disorders HFD mouse model Obesity-related inflammation Pro-inflammatory phenotype High-fat diet Promising therapeutic strategy Chemical small molecules Fatty acid oxidation Chronic inflammation Magnetic cell sorting Fat diet M1 polarization M2 polarization Metabolic dysfunction Mouse model Therapeutic strategies Inflammation CDDO-Me Compound oleanolic acid Inflammation treatment Histological analysis", + "iRGD-guided tumor-penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer Lo JH, Hao L, Muzumdar MD , Raghavan S, Kwon EJ, Pulver EM, Hsu F, Aguirre AJ, Wolpin BM, Fuchs CS , Hahn WC, Jacks T, Bhatia SN. iRGD-guided tumor-penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer . Molecular Cancer Therapeutics 2018, 17: molcanther.1090.2017. PMID: 30097486 , PMCID: PMC6298224 , DOI: 10.1158/1535-7163.mct-17-1090 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Adenocarcinoma Animals Cell Line, Tumor Cell Proliferation Cell-Penetrating Peptides Mice, Nude Models, Biological Nanoparticles Oligopeptides Organoids Pancreatic Neoplasms Polyethylene Glycols Proto-Oncogene Proteins p21(ras) RNA, Small Interfering Concepts Pancreatic ductal adenocarcinoma Pancreatic cancer Cancer-related death Receptor expression patterns Site of disease PDAC cell lines Mol Cancer Ther Therapeutic trials Autochthonous tumors Ductal adenocarcinoma Mouse model Stromal barrier Tumor growth Systemic delivery Neuropilin-1 Peptide iRGD Tumor-penetrating ability Three-dimensional organoids SiRNA Tumor targeting Cell lines Therapy Cancer Stroma IRGD", + "Small molecule activators of protein phosphatase 2A for the treatment of castration-resistant prostate cancer. McClinch K, Avelar R, Callejas D, Izadmehr S, Wiredja D, Perl A, Sangodkar J, Kastrinsky D, Schlatzer D, Cooper M, Kiselar J, Stachnik A, Yao S, Hoon D, McQuaid D , Zaware N, Gong Y, Brautigan D, Plymate S, Sprenger C, Oh W , Levine A, Kirschenbaum A, Sfakianos J, Sears R, DiFeo A, Ioannou Y, Ohlmeyer M, Narla G, Galsky M. Small molecule activators of protein phosphatase 2A for the treatment of castration-resistant prostate cancer. Cancer Research 2018, 78: canres.0123.2017. PMID: 29358171 , PMCID: PMC5899650 , DOI: 10.1158/0008-5472.can-17-0123 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Cell Line, Tumor Enzyme Activators Heterografts Humans Male Mice Mice, SCID Phosphoproteins Prostatic Neoplasms, Castration-Resistant Protein Phosphatase 2C Proteomics Receptors, Androgen RNA, Messenger Small Molecule Libraries Concepts Castrate-resistant prostate cancer Androgen receptor Prostate cancer CRPC cells Human castrate-resistant prostate cancer Multiple oncogenic signaling pathways Small molecule activators Androgen deprivation therapy Advanced prostate cancer Primary prostate cancer Murine xenograft model Growth inhibitory effects Deprivation therapy CRPC treatment Time-dependent manner Oncogenic signaling pathways Preclinical proof Xenograft model AR degradation Cancer Res Tumor suppressor PP2A Tumor formation Cancer Aberrant reactivation Signaling pathways", + "Differences in Nanoparticle Uptake in Transplanted and Autochthonous Models of Pancreatic Cancer Tao Z, Muzumdar MD , Detappe A, Huang X, Xu ES, Yu Y, Mouhieddine TH, Song H, Jacks T, Ghoroghchian PP. Differences in Nanoparticle Uptake in Transplanted and Autochthonous Models of Pancreatic Cancer . Nano Letters 2018, 18: 2195-2208. PMID: 29533667 , PMCID: PMC5957485 , DOI: 10.1021/acs.nanolett.7b04043 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Antineoplastic Agents Carcinoma, Pancreatic Ductal Cell Line, Tumor Female Humans Lactones Mice Mice, Nude Micelles Nanoparticles Neoplasm Transplantation Neoplasms, Experimental Optical Imaging Organoplatinum Compounds Oxaliplatin Pancreatic Neoplasms Polyethylene Glycols Concepts Pancreatic ductal adenocarcinoma Human pancreatic ductal adenocarcinoma Pancreatic tumors Mouse model Autochthonous model Poor overall prognosis Autochthonous mouse model Autochthonous tumor model Tumor cell clusters Overall prognosis Survival outcomes Pancreatic cancer Ductal adenocarcinoma Transplanted tumor Preclinical studies Free drug formulation Dense stroma Preclinical testing Tumor model Tumors Oxaliplatin Noninvasive optical imaging Anticancer agents Anticancer drugs Therapeutic formulations", + "Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells Chen PY, Muzumdar M , Dorans KJ, Robbins R, Bhutkar A, Del Rosario A, Mertins P, Qiao J, Schafer AC, Gertler F, Carr S, Jacks T. Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells . Cancer Research 2018, 78: 985-1002. PMID: 29279356 , PMCID: PMC5837062 , DOI: 10.1158/0008-5472.can-17-2129 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Cell Line, Tumor Drug Resistance, Neoplasm Gene Expression Profiling Gene Knockdown Techniques Humans Mice Mice, Inbred NOD Mice, SCID Pancreatic Neoplasms Protein Kinase Inhibitors Proto-Oncogene Proteins p21(ras) Signal Transduction Concepts Murine PDAC cells PDAC cells Nontranscriptional mechanisms KRAS inhibitors Global phosphoproteomic profiling Activated KRAS Hallmark genetic alterations Transcriptional changes Phosphoproteomic profiling Cell signaling Cell states Pathway components Tumor-initiating capacity Pancreatic ductal adenocarcinoma Temporal control Genetic alterations Cell morphology Mechanistic directions Kras expression KRAS Cells Proliferative kinetics Inhibitors Novel KRAS inhibitors Adherence properties", + "Yale Cancer Biology Institute Advanced Bioscience Center 840 West Campus Drive West Haven, CT 06516 Maps & Directions", + "Calendar", + "", + "", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Myung Lab", + "lab_url": "https://medicine.yale.edu/lab/myung/", + "research_bio": "INFORMATION FOR The Myung Lab investigates the processes underlying hair follicle development and regeneration in skin. We combine cutting-edge techniques, including multi-photon imaging, quantitative RNA fluorescent in situ hybridization, single-cell RNA/ATAC sequencing, and CUT&RUN with in vivo mouse genetic models to study the molecular and cellular mechanisms that control embryonic hair follicle development. Our goal is to apply this knowledge in adult skin to promote hair follicle regeneration and wound healing. Copy Link Vice Chair of Research. Associate Professor of Dermatology and of Pathology.", + "publications_page": "https://medicine.yale.edu/lab/myung/research/", + "publications": [ + "Yale School of Medicine /", + "Dermatology /", + "Research & Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research & Publications", + "", + "", + "", + "", + "", + "", + "How do hair follicles initially form during embryogenesis?", + "How can hair follicles form de novo in adult skin?", + "Can mechanisms of development and regeneration be repurposed to suppress skin cancer?", + "Cluster-independent multiscale marker identification in single-cell RNA-seq data using localized marker detector (LMD). Li R, Qu R, Parisi F, Strino F, Lam H, Stanley JS 3rd, Cheng X, Myung P, Kluger Y. Commun Biol. 2025 Jul 16; 2025 Jul 16. PMID: 40670619.", + "Interaction of Wnt and SHH gradients synchronizes cell cycle exit and differentiation. Li R, Jiang Y, Platt S, Peterson KA, Lam H, Van S, Lim CH, Levinsohn J, Barber EL, Wang D, Taketo MM, Kluger Y, Myung P. bioRxiv. 2025 Jul 1; 2025 Jul 1. PMID: 40631112.", + "Genetic Analysis of Epidermal Inclusion Cysts Reveals NEK9 Variants as a Common Driver of Comedogenesis and Cyst Formation. Ellis KT, Myung P, Cohen J, Choate KA. J Invest Dermatol. 2025 Jun; 2024 Dec 18. PMID: 39706256.", + "Cognitive bias in the patient encounter: Part II. Debiasing using an adaptive toolbox. Ko CJ, Gehlhausen JR, Cohen JM, Jiang Y, Myung P, Croskerry P. J Am Acad Dermatol. 2025 Feb; 2024 Apr 6. PMID: 38588820.", + "Gene trajectory inference for single-cell data by optimal transport metrics. Qu R, Cheng X, Sefik E, Stanley Iii JS, Landa B, Strino F, Platt S, Garritano J, Odell ID, Coifman R, Flavell RA, Myung P, Kluger Y. Nat Biotechnol. 2025 Feb; 2024 Apr 5. PMID: 38580861.", + "LMD: Cluster-Independent Multiscale Marker Identification in Single-cell RNA-seq Data. Li R, Qu R, Parisi F, Strino F, Lam H, Stanley JS, Cheng X, Myung P, Kluger Y. bioRxiv. 2024 Oct 17; 2024 Oct 17. PMID: 38014159.", + "The development of hair follicles and nail. Lee SH, Platt S, Lim CH, Ito M, Myung P. Dev Biol. 2024 Sep; 2024 May 15. PMID: 38759942.", + "Rapidly progressive subungual gray-brown melanonychia. Echeandia-Francis C, Nock MR, Myung P, Zubek AE. JAAD Case Rep. 2024 Feb; 2024 Jan 28. PMID: 38414828.", + "Solving a molecular cryptogram for the human fingerprint. Myung P, Ito M. Cell. 2023 Mar 2. PMID: 36868211.", + "The origins of skin diversity: lessons from dermal fibroblasts. Myung P, Andl T, Atit R. Development. 2022 Dec 1; 2022 Nov 29. PMID: 36444877.", + "Segmental basaloid follicular hamartomas derive from a post-zygotic SMO p.L412F pathogenic variant and express hair follicle development-related proteins in a pattern that distinguish them from basal cell carcinomas. Atzmony L, Ugwu N, Bercovitch LG, Robinson-Bostom L, Ko CJ, Myung P, Choate KA. Am J Med Genet A. 2022 Dec; 2022 Aug 16. PMID: 35972041.", + "Decomposing a deterministic path to mesenchymal niche formation by two intersecting morphogen gradients. Qu R, Gupta K, Dong D, Jiang Y, Landa B, Saez C, Strickland G, Levinsohn J, Weng PL, Taketo MM, Kluger Y, Myung P. Dev Cell. 2022 Apr 25; 2022 Apr 13. PMID: 35421372.", + "Pink plaques on the face of an adolescent male. Gehlhausen JR, Myung P, Zubek A. Int J Dermatol. 2021 Jun; 2020 Oct 20. PMID: 33084046.", + "Tender subcubcutaneous plaques in a patient with acute myeloid leukemia. Olamiju B, Myung P, Grant M, Leventhal JS. Int J Dermatol. 2021 Mar; 2020 May 19. PMID: 32424815.", + "Inference and analysis of cell-cell communication using CellChat. Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, Kuan CH, Myung P, Plikus MV, Nie Q. Nat Commun. 2021 Feb 17; 2021 Feb 17. PMID: 33597522.", + "Cutaneous Vasculitis After Ustekinumab Induction in Crohn's Disease. Chugh R, Proctor DD, Little A, Myung P, Cowper S, Imaeda S, Pashankar DS, Al-Bawardy B. Inflamm Bowel Dis. 2021 Feb 16. PMID: 33179735.", + "Cutaneous Involvement in Plasma Cell Myeloma. Panse G, Subtil A, McNiff JM, Glusac EJ, Ko CJ, Galan A, Myung P, Xu ML. Am J Clin Pathol. 2021 Jan 4. PMID: 32885235.", + "Ixekizumab-induced alopecia areata. Eldirany SA, Myung P, Bunick CG. JAAD Case Rep. 2020 Jan; 2019 Dec 26. PMID: 31909139.", + "A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease. Sun Q, Lee W, Mohri Y, Takeo M, Lim CH, Xu X, Myung P, Atit RP, Taketo MM, Moubarak RS, Schober M, Osman I, Gay DL, Saur D, Nishimura EK, Ito M. Nat Commun. 2019 Nov 4; 2019 Nov 4. PMID: 31685822.", + "Multinucleate cell angiohistiocytoma: A clinicopathologic study of 62 cases and proposed diagnostic criteria. Roy SF, Dong D, Myung P, McNiff JM. J Cutan Pathol. 2019 Aug; 2019 Apr 23. PMID: 30927287.", + "Putting Cell Competition under the Microscope. Levinsohn J, Myung P. Dev Cell. 2019 Jun 17. PMID: 31211989.", + "Single-Cell Analysis Reveals a Hair Follicle Dermal Niche Molecular Differentiation Trajectory that Begins Prior to Morphogenesis. Gupta K, Levinsohn J, Linderman G, Chen D, Sun TY, Dong D, Taketo MM, Bosenberg M, Kluger Y, Choate K, Myung P. Dev Cell. 2019 Jan 7; 2018 Dec 27. PMID: 30595533.", + "Cutaneous immunohistochemical staining pattern of p53β isoforms. Ko CJ, Myung P, Leffell DJ, Bourdon JC. J Clin Pathol. 2018 Dec; 2018 Oct 10. PMID: 30305316.", + "Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing. Lim CH, Sun Q, Ratti K, Lee SH, Zheng Y, Takeo M, Lee W, Rabbani P, Plikus MV, Cain JE, Wang DH, Watkins DN, Millar S, Taketo MM, Myung P, Cotsarelis G, Ito M. Nat Commun. 2018 Nov 21; 2018 Nov 21. PMID: 30464171.", + "Dissecting Wnt Signaling for Melanocyte Regulation during Wound Healing. Sun Q, Rabbani P, Takeo M, Lee SH, Lim CH, Noel ES, Taketo MM, Myung P, Millar S, Ito M. J Invest Dermatol. 2018 Jul; 2018 Feb 8. PMID: 29428355.", + "Hardwiring Stem Cell Communication through Tissue Structure. Xin T, Greco V, Myung P. Cell. 2016 Mar 10. PMID: 26967287.", + "Diverse cutaneous manifestations of Erdheim-Chester disease in a woman with a history of Langerhans cell histiocytosis. Neckman JP, Kim J, Mathur M, Myung P, Girardi M. JAAD Case Rep. 2016 Mar; 2016 Mar 5. PMID: 27051852.", + "Stem Cells Show Parental Control. Myung P, Greco V. Cell. 2015 Jul 30. PMID: 26232219.", + "Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool. Mesa KR, Rompolas P, Zito G, Myung P, Sun TY, Brown S, Gonzalez DG, Blagoev KB, Haberman AM, Greco V. Nature. 2015 Jun 4; 2015 Apr 6. PMID: 25849774.", + "β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche. Deschene ER, Myung P, Rompolas P, Zito G, Sun TY, Taketo MM, Saotome I, Greco V. Science. 2014 Mar 21. PMID: 24653033.", + "Epithelial Wnt ligand secretion is required for adult hair follicle growth and regeneration. Myung PS, Takeo M, Ito M, Atit RP. J Invest Dermatol. 2013 Jan; 2012 Jul 19. PMID: 22810306.", + "Dissecting the bulge in hair regeneration. Myung P, Ito M. J Clin Invest. 2012 Feb; 2012 Feb 1. PMID: 22293183.", + "Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration. Rabbani P, Takeo M, Chou W, Myung P, Bosenberg M, Chin L, Taketo MM, Ito M. Cell. 2011 Jun 10. PMID: 21663796.", + "Defining the hair follicle stem cell (Part II). Myung P, Andl T, Ito M. J Cutan Pathol. 2009 Oct. PMID: 19712246.", + "Defining the hair follicle stem cell (Part I). Myung P, Andl T, Ito M. J Cutan Pathol. 2009 Sep. PMID: 19674210.", + "Eosinophilic granuloma manifesting as painless cervical lymphadenopathy in a patient positive for human immunodeficiency virus 1. Myung PS, Kundu M, Abboud SK. Arch Otolaryngol Head Neck Surg. 2008 Feb. PMID: 18283165.", + "Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function. Singer AL, Bunnell SC, Obstfeld AE, Jordan MS, Wu JN, Myung PS, Samelson LE, Koretzky GA. J Biol Chem. 2004 Apr 9; 2004 Jan 13. PMID: 14722089.", + "Macrophage activation and Fcgamma receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors. Nichols KE, Haines K, Myung PS, Newbrough S, Myers E, Jumaa H, Shedlock DJ, Shen H, Koretzky GA. J Leukoc Biol. 2004 Mar; 2003 Dec 23. PMID: 14694181.", + "Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling. Judd BA, Myung PS, Obergfell A, Myers EE, Cheng AM, Watson SP, Pear WS, Allman D, Shattil SJ, Koretzky GA. J Exp Med. 2002 Mar 18. PMID: 11901197.", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Navaratnam Lab", + "lab_url": "https://medicine.yale.edu/lab/navaratnam/", + "research_bio": "INFORMATION FOR Copy Link My clinical interests and responsibilities include hearing and balance, as well as stroke. I have a weekly clinic in the Hearing and Balance Center, where I see patients with a range of hearing and balance problems. For more details please see theHearing and Balance Center's Website. I also attend on the in-patient and consult service at YNHH and I am a member of the YNHH stroke service, which provides 24/7 stroke coverage for Yale New Haven Hospital. I am the director of the clinical neuroscience module for second-year medical students. I also direct a course on the molecular and cellular mechanisms of neurological disease. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Neuroimmunology Lab", + "lab_url": "https://medicine.yale.edu/lab/hafler/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/hafler/publications/", + "publications": null + }, + { + "lab_name": "NeuroPET Imaging Program", + "lab_url": "https://medicine.yale.edu/lab/neuropet/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Neuroscience of Learning and Memory", + "lab_url": "https://medicine.yale.edu/lab/brown/", + "research_bio": "INFORMATION FOR My laboratory studies the mechanisms of learning and memory and their age-related changes. Research ranges from the molecular to the behavioral levels of analysis, with a focus on rapid forms of learning. The medial temporal lobe (MTL) brain structures on which I have concentrated include the hippocampus, amygdala, and perirhinal cortex. Collectively, these MTL structures are implicated in aspects of declarative and emotional memory and they are early targets of neurodegeneration in Alzheimer's disease. My working hypothesis has been that associative long-term potentiation (LTP) a Hebbian form of synaptic plasticity is responsible for certain rapid forms of associative learning in the MTLs and elsewhere. Accordingly, one long-term research thrust has been to develop techniques that enable a rigorous analysis and understanding of synapses and neurons in these structures, all of which appear to participate in rapid learning. In vitro methods applied to brain slices include current- and voltage clamp analysis, using sharp and whole-cell recordings; quantal analysis; confocal and dual-photon microscopy; Ca2+ imaging; and dual-labeling and anatomical reconstructions of recorded neurons. It now appears that Hebbian synaptic plasticity is widespread throughout phylogeny. A second long-term research objective has been to understand the causal connections between synaptic and neuronal modifications, the affected circuits, and the resulting behavioral or cognitive changes. In vivo methods include Pavlovian and instrumental conditioning, behavioral neuropharmacology, and behavioral neurophysiology. These experiments can be followed by further in vitro analysis. Computer simulations of synapses, neurons, and circuits are used to evaluate hypotheses, to interpret findings, and to integrate information across different levels of analysis.", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Nguyen Lab", + "lab_url": "https://medicine.yale.edu/lab/nguyen/", + "research_bio": "INFORMATION FOR Nguyen Lab Group 2023 Cancer metastasis remains the major cause of cancer-related deaths. We use multi-disciplinary methods to study the cellular and molecular origins of invasive cancers, including those originating from the lungs. In sum, our approach strives to answer the following question: how does the biology of cancer metastasis relate to normal physiological processes? ReadThis Storyand see ourResearchpage for more on what we're thinking about. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/nguyen/publications/", + "publications": [ + "Yale School of Medicine /", + "Pathology /", + "Research", + "News", + "People", + "Publications", + "Contact", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "Contact", + "News", + "", + "", + "", + "", + "", + "", + "Intracranial metastases from solid tumors: Call to Action and Consensus from the Society for Neuro-Oncology and American Society of Clinical Oncology Collaborative. Sharma A, Boyce Kennedy L, Van Swearingen AED, Ahluwalia MS, Bagley SJ, Chiang VL, Chung C, Cittelly DM, Daras M, Davies MA, Fecci PE, Haas-Kogan DA, Hattangadi-Gluth JA, Jerzak KJ, Kim MM, Malani R, Mehta MP, Moss NS, Neman J, Nguyen DX, Priceman SJ, Sahebjam S, Shih HA, Soffietti R, Wang N, Zimmer A, Goldberg S, Khasraw M, Anders CK, Lin NU. Neuro Oncol. 2025 Oct 1; 2025 Oct 1. PMID: 41051254.", + "An in vivo screen identifies NAT10 as a master regulator of brain metastasis. Chen JF, Xu P, Cai WL, Chen H, Wingrove E, Shi X, Li W, Biancon G, Zhang M, Balabaki A, Krop ED, Asare E, Zhang Y, Yin M, Tebaldi T, Meier JL, Westbrook TF, Halene S, Liu Y, Shen H, Nguyen DX, Yan Q. Sci Adv. 2025 Mar 28; 2025 Mar 26. PMID: 40138393.", + "ASCL1 Drives Tolerance to Osimertinib in EGFR Mutant Lung Cancer in Permissive Cellular Contexts. Hu B, Wiesehöfer M, de Miguel FJ, Liu Z, Chan LH, Choi J, Melnick MA, Arnal Estape A, Walther Z, Zhao D, Lopez-Giraldez F, Wurtz A, Cai G, Fan R, Gettinger S, Xiao A, Yan Q, Homer R, Nguyen DX, Politi K. Cancer Res. 2024 Apr 15. PMID: 38359163.", + "Patient-Derived Models of Cancer in the NCI PDMC Consortium: Selection, Pitfalls, and Practical Recommendations. Habowski AN, Budagavi DP, Scherer SD, Aurora AB, Caligiuri G, Flynn WF, Langer EM, Brody JR, Sears RC, Foggetti G, Arnal Estape A, Nguyen DX, Politi KA, Shen X, Hsu DS, Peehl DM, Kurhanewicz J, Sriram R, Suarez M, Xiao S, Du Y, Li XN, Navone NM, Labanca E, Willey CD. Cancers (Basel). 2024 Jan 29; 2024 Jan 29. PMID: 38339316.", + "Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer. de Miguel FJ, Gentile C, Feng WW, Silva SJ, Sankar A, Exposito F, Cai WL, Melnick MA, Robles-Oteiza C, Hinkley MM, Tsai JA, Hartley AV, Wei J, Wurtz A, Li F, Toki MI, Rimm DL, Homer R, Wilen CB, Xiao AZ, Qi J, Yan Q, Nguyen DX, Jänne PA, Kadoch C, Politi KA. Cancer Cell. 2023 Aug 14; 2023 Aug 3. PMID: 37541244.", + "Epigenetic markers and therapeutic targets for metastasis. Kravitz CJ, Yan Q, Nguyen DX. Cancer Metastasis Rev. 2023 Jun; 2023 Jun 7. PMID: 37286865.", + "Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer. Adua SJ, Arnal-Estapé A, Zhao M, Qi B, Liu ZZ, Kravitz C, Hulme H, Strittmatter N, López-Giráldez F, Chande S, Albert AE, Melnick MA, Hu B, Politi K, Chiang V, Colclough N, Goodwin RJA, Cross D, Smith P, Nguyen DX. Nat Commun. 2022 Dec 12; 2022 Dec 12. PMID: 36509758.", + "Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities. Karz A, Dimitrova M, Kleffman K, Alvarez-Breckenridge C, Atkins MB, Boire A, Bosenberg M, Brastianos P, Cahill DP, Chen Q, Ferguson S, Forsyth P, Glitza Oliva IC, Goldberg SB, Holmen SL, Knisely JPS, Merlino G, Nguyen DX, Pacold ME, Perez-Guijarro E, Smalley KSM, Tawbi HA, Wen PY, Davies MA, Kluger HM, Mehnert JM, Hernando E. Pigment Cell Melanoma Res. 2022 Nov; 2022 Sep 1. PMID: 35912544.", + "Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation. Cai WL, Chen JF, Chen H, Wingrove E, Kurley SJ, Chan LH, Zhang M, Arnal-Estape A, Zhao M, Balabaki A, Li W, Yu X, Krop ED, Dou Y, Liu Y, Jin J, Westbrook TF, Nguyen DX, Yan Q. Elife. 2022 Aug 31; 2022 Aug 31. PMID: 36043466.", + "Preclinical Models for the Study of Lung Cancer Pathogenesis and Therapy Development. Arnal-Estapé A, Foggetti G, Starrett JH, Nguyen DX, Politi K. Cold Spring Harb Perspect Med. 2021 Dec 1; 2021 Dec 1. PMID: 34518338.", + "Measuring Faculty Effort: A Quantitative Approach That Aligns Personal and Institutional Goals in Pathology at Yale. Morrow JS, Gershkovich P, Gibson J, Gilshannon M, Kowalski D, Levi AW, Nguyen DX, Rimm DL, Xu ML, Sinard J. Acad Pathol. 2021 Jan-Dec; 2021 Oct 7. PMID: 34646939.", + "Condensing and constraining WNT by TGF-β. Patel KD, Nguyen DX. Nat Cell Biol. 2021 Mar. PMID: 33723426.", + "Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs. Colclough N, Chen K, Johnström P, Strittmatter N, Yan Y, Wrigley GL, Schou M, Goodwin R, Varnäs K, Adua SJ, Zhao M, Nguyen DX, Maglennon G, Barton P, Atkinson J, Zhang L, Janefeldt A, Wilson J, Smith A, Takano A, Arakawa R, Kondrashov M, Malmquist J, Revunov E, Vazquez-Romero A, Moein MM, Windhorst AD, Karp NA, Finlay MRV, Ward RA, Yates JWT, Smith PD, Farde L, Cheng Z, Cross DAE. Clin Cancer Res. 2021 Jan 1; 2020 Oct 7. PMID: 33028591.", + "Tumor progression and chromatin landscape of lung cancer are regulated by the lineage factor GATA6. Arnal-Estapé A, Cai WL, Albert AE, Zhao M, Stevens LE, López-Giráldez F, Patel KD, Tyagi S, Schmitt EM, Westbrook TF, Nguyen DX. Oncogene. 2020 Apr; 2020 Mar 10. PMID: 32157212.", + "Specific chromatin landscapes and transcription factors couple breast cancer subtype with metastatic relapse to lung or brain. Cai WL, Greer CB, Chen JF, Arnal-Estapé A, Cao J, Yan Q, Nguyen DX. BMC Med Genomics. 2020 Mar 6; 2020 Mar 6. PMID: 32143622.", + "Adaptive Protein Translation by the Integrated Stress Response Maintains the Proliferative and Migratory Capacity of Lung Adenocarcinoma Cells. Albert AE, Adua SJ, Cai WL, Arnal-Estapé A, Cline GW, Liu Z, Zhao M, Cao PD, Mariappan M, Nguyen DX. Mol Cancer Res. 2019 Dec; 2019 Sep 24. PMID: 31551255.", + "Hair follicle regeneration suppresses Ras-driven oncogenic growth. Pineda CM, Gonzalez DG, Matte-Martone C, Boucher J, Lathrop E, Gallini S, Fons NR, Xin T, Tai K, Marsh E, Nguyen DX, Suozzi KC, Beronja S, Greco V. J Cell Biol. 2019 Oct 7; 2019 Sep 5. PMID: 31488583.", + "Perilesional edema in brain metastases: potential causes and implications for treatment with immune therapy. Tran TT, Mahajan A, Chiang VL, Goldberg SB, Nguyen DX, Jilaveanu LB, Kluger HM. J Immunother Cancer. 2019 Jul 30; 2019 Jul 30. PMID: 31362777.", + "Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis. Wingrove E, Liu ZZ, Patel KD, Arnal-Estapé A, Cai WL, Melnick MA, Politi K, Monteiro C, Zhu L, Valiente M, Kluger HM, Chiang VL, Nguyen DX. Cell Rep. 2019 Apr 23. PMID: 31018140.", + "Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment. Stevens LE, Arnal-Estapé A, Nguyen DX. J Vis Exp. 2018 Jun 28; 2018 Jun 28. PMID: 30010648.", + "Extracellular Matrix Receptor Expression in Subtypes of Lung Adenocarcinoma Potentiates Outgrowth of Micrometastases. Stevens LE, Cheung WKC, Adua SJ, Arnal-Estapé A, Zhao M, Liu Z, Brewer K, Herbst RS, Nguyen DX. Cancer Res. 2017 Apr 15; 2017 Feb 14. PMID: 28196904.", + "Lineage factors and differentiation states in lung cancer progression. Cheung WK, Nguyen DX. Oncogene. 2015 Nov 19; 2015 Mar 30. PMID: 25823023.", + "Sweets for a bitter end: lung cancer cell-surface protein glycosylation mediates metastatic colonization. Arnal-Estapé A, Nguyen DX. Cancer Discov. 2015 Feb. PMID: 25656895.", + "Neuregulin 1-activated ERBB4 interacts with YAP to induce Hippo pathway target genes and promote cell migration. Haskins JW, Nguyen DX, Stern DF. Sci Signal. 2014 Dec 9; 2014 Dec 9. PMID: 25492965.", + "The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor. Karlin KL, Mondal G, Hartman JK, Tyagi S, Kurley SJ, Bland CS, Hsu TY, Renwick A, Fang JE, Migliaccio I, Callaway C, Nair A, Dominguez-Vidana R, Nguyen DX, Osborne CK, Schiff R, Yu-Lee LY, Jung SY, Edwards DP, Hilsenbeck SG, Rosen JM, Zhang XH, Shaw CA, Couch FJ, Westbrook TF. Cell Rep. 2014 Nov 20; 2014 Nov 6. PMID: 25453754.", + "Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk. Zito G, Saotome I, Liu Z, Ferro EG, Sun TY, Nguyen DX, Bilguvar K, Ko CJ, Greco V. Nat Commun. 2014 Mar 26; 2014 Mar 26. PMID: 24667544.", + "Histone demethylase RBP2 is critical for breast cancer progression and metastasis. Cao J, Liu Z, Cheung WK, Zhao M, Chen SY, Chan SW, Booth CJ, Nguyen DX, Yan Q. Cell Rep. 2014 Mar 13; 2014 Feb 27. PMID: 24582965.", + "EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Breindel JL, Haskins JW, Cowell EP, Zhao M, Nguyen DX, Stern DF. Cancer Res. 2013 Aug 15; 2013 Jun 21. PMID: 23794705.", + "Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis. Cheung WK, Zhao M, Liu Z, Stevens LE, Cao PD, Fang JE, Westbrook TF, Nguyen DX. Cancer Cell. 2013 Jun 10; 2013 May 23. PMID: 23707782.", + "Cell lineage specification in tumor progression and metastasis. Cao PD, Cheung WK, Nguyen DX. Discov Med. 2011 Oct. PMID: 22031670.", + "Tracing the origins of metastasis. Nguyen DX. J Pathol. 2011 Jan; 2010 Oct 29. PMID: 21125675.", + "Modeling metastasis in the mouse. Bos PD, Nguyen DX, Massagué J. Curr Opin Pharmacol. 2010 Oct; 2010 Jul 1. PMID: 20598638.", + "Tumor self-seeding by circulating cancer cells. Kim MY, Oskarsson T, Acharyya S, Nguyen DX, Zhang XH, Norton L, Massagué J. Cell. 2009 Dec 24. PMID: 20064377.", + "WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Nguyen DX, Chiang AC, Zhang XH, Kim JY, Kris MG, Ladanyi M, Gerald WL, Massagué J. Cell. 2009 Jul 10; 2009 Jul 2. PMID: 19576624.", + "Genes that mediate breast cancer metastasis to the brain. Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX, Minn AJ, van de Vijver MJ, Gerald WL, Foekens JA, Massagué J. Nature. 2009 Jun 18; 2009 May 6. PMID: 19421193.", + "Metastasis: from dissemination to organ-specific colonization. Nguyen DX, Bos PD, Massagué J. Nat Rev Cancer. 2009 Apr. PMID: 19308067.", + "Genetic determinants of cancer metastasis. Nguyen DX, Massagué J. Nat Rev Genet. 2007 May. PMID: 17440531.", + "Lung metastasis genes couple breast tumor size and metastatic spread. Minn AJ, Gupta GP, Padua D, Bos P, Nguyen DX, Nuyten D, Kreike B, Zhang Y, Wang Y, Ishwaran H, Foekens JA, van de Vijver M, Massagué J. Proc Natl Acad Sci U S A. 2007 Apr 17; 2007 Apr 9. PMID: 17420468.", + "Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Gupta GP, Nguyen DX, Chiang AC, Bos PD, Kim JY, Nadal C, Gomis RR, Manova-Todorova K, Massagué J. Nature. 2007 Apr 12. PMID: 17429393.", + "Brady Memorial Laboratory 310 Cedar Street, BML338 New Haven, CT 06520-8023 Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Niklason Lab", + "lab_url": "https://medicine.yale.edu/lab/niklason/", + "research_bio": "INFORMATION FOR Our laboratory seeks to utilize cells, in combination with what we know about their function, embryonic development, and physiological environments, to create functional tissues and organs that may one day help patients. This approach to Regenerative Medicine is firmly rooted in biology, yet makes ample use of engineering principles such as Design Criteria, biomechanical forces, biomimetic bioreactors, and the like. For our work in vascular engineering, we are focusing on the differentiation of human iPS cells into vascular smooth muscle and endothelial phenotypes, novel bioreactor development, and chemical modifications of engineered vascular tissues to enhance their biocompatibility. We focus on both “large vessel” (i.e. arterial) and “small vessel” (i.e. capillary) engineering, using both small and large animals as testbeds. For our work in lung cell therapy and whole lung regeneration, we utilize acellular lung scaffolds that are generated by the careful and quantitative decellularization of adult organs from a variety of species. These scaffolds are then repopulated with stem cell-derived and differentiated cells of various lineages. Design goals are the generation of patent microvasculature, differentiated epithelial lining, and appropriate tissue mechanics including surfactant-dependent compliance. Copy Link Airway cast of a decellularized adult rat lung that is imaged by scanning electron microscopy. Preservation of alveolar airsac structures is evident. High resolution computed tomography 3-D reconstruction of rat left pulmonary artery, after decellularization. Preservation of multiple generations of vascular branching and hierarchy is evident. Decellularized rat lung scaffold that is repopulated with both microvascular lung endothelial cells, and with neonatal rat mixed epithelium. Extensive repopulation of airways and vasculature is achievable. First implantation in the U.S. of an engineered artery in a patient, wherein the artery was engineered and then decellularized using technology developed in the Niklason laboratory. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/niklason/publications", + "publications": null + }, + { + "lab_name": "Nitabach Lab", + "lab_url": "https://medicine.yale.edu/lab/nitabach/", + "research_bio": "INFORMATION FOR Lighting a path to understanding the brain's 'language' The Nitabach lab is focused broadly on the use of genetic, physiological, and behavioral approaches to understanding the information processing principles by which neural circuits control animal behavior. Particular behaviors we are interested in include sleep, circadian rhythms, multisensory integration, and learning. Most of our work is pursued using as model organisms Drosophila melanogaster fruit flies and Caenorhabditis elegans nematode fruit worms. Specific technical approaches employed include whole-cell patch-clamp electrophysiology, optical imaging of membrane voltage and intracellular second messengers, cell-specific genetic targeting of biophysical and biochemical effectors, and sophisticated behavioral assays. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/nitabach/publications", + "publications": null + }, + { + "lab_name": "Noonan Lab", + "lab_url": "https://medicine.yale.edu/lab/noonan/", + "research_bio": "INFORMATION FOR Copy Link What makes us human? Our capacities for invention, language and abstract thought set us apart from all other living things. With the sequencing of the human genome and the genomes of our closest primate relatives, locating the origins of such uniquely human characteristics has become a tractable genetic problem. Many human traits are based on anatomical changes, including increased brain size and changes in the morphology of the limbs, that evolved due to genetic changes in development. Our laboratory uses a combination of computational and in vivo experimental approaches to study human-specific changes in developmental gene regulation. We are pursuing an integrated strategy that synthesizes maps of human-specific accelerated evolution in noncoding DNAs, in vivo analysis of cis-regulatory elements, and functional genomic atlases of human development to reveal the genetic basis of unique human biology. Copy Link Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Nutrition, Exercise and Weight Management Studies for Cancer Prevention and Survivorship", + "lab_url": "https://medicine.yale.edu/lab/irwin/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "O'Connor Lab", + "lab_url": "https://medicine.yale.edu/lab/oconnor/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/oconnor/publications/", + "publications": [ + "Yale School of Medicine /", + "Neurology /", + "About the Lab Members Myasthenia Gravis Multiple Sclerosis Neuromyelitis Spectrum Disorder (NMOSD) Inflammatory Myopathies", + "Members", + "Myasthenia Gravis", + "Multiple Sclerosis", + "Neuromyelitis Spectrum Disorder (NMOSD)", + "Inflammatory Myopathies", + "Contact Us", + "Photos & Events", + "News", + "Recent Publications", + "Summary of Disclosures", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "About the Lab", + "Photos & Events", + "Recent Publications", + "Summary of Disclosures", + "Contact Us", + "News", + "", + "", + "", + "", + "", + "", + "IgA autoantibodies demonstrate a novel mechanism of MuSK myasthenia gravis pathology. Masi G, Chen K, Bayer AC, Bayarri-Olmos R, Pham MC, Wallace A, Falso S, Evoli A, Iorio R, Hoehn KB, Iwasaki A, Nowak RJ, O'Connor KC. Brain. 2025 Oct 28; 2025 Oct 28. PMID: 41147199.", + "Therapeutic IgG- and IgM-specific proteases disarm the acetylcholine receptor autoantibodies that drive myasthenia gravis pathology. Bayer AC, Sanmarco LM, Pellerin A, Masi G, Plasencia A, Anderson JM, Nowak RJ, Damato V, Massacesi L, Pham MC, Khani-Habibabadi F, Vital H, Higginson-Scott N, Otipoby KL, Xing Y, Mascanfroni ID, O'Connor KC. Proc Natl Acad Sci U S A. 2025 Oct 28; 2025 Oct 21. PMID: 41118207.", + "Screening for Congenital Myasthenic Syndromes in Adults With Seronegative Myasthenia Gravis Using Next-Generation Sequencing. Krenn M, Wagner M, Schuller H, Pugna I, Rath J, Zulehner G, Keritam O, Weng R, Koneczny I, Schiavo E, Damato V, Kleinveld VEA, Kiss C, Gold V, Quasthoff S, Masi G, O'Connor KC, Canning J, Waters PJ, Lenz D, Blüthner M, Pavlov M, Graf E, Winkelmann J, Löscher WN, Zimprich F, Cetin H. Neurology. 2025 Oct 21; 2025 Sep 26. PMID: 41004697.", + "A Distinct Immunological Signature in Late-Onset Myasthenia Gravis: Insights from an Exploratory Proteomics Study. Roy B, Chen J, Khani-Habibabadi F, McLaren N, Soliven BC, Juel VC, O'Connor KC, Nowak RJ, Kusner LL, Kaminski HJ. Ann Neurol. 2025 Sep 6; 2025 Sep 6. PMID: 40913424.", + "AChR Autoantibody Pathogenic Properties Are Heterogeneously Distributed and Undergo Temporal Changes Among Patients With Myasthenia Gravis. Khani-Habibabadi F, Roy B, Pham MC, Obaid AH, Filipek B, Nowak RJ, O'Connor KC. Neurol Neuroimmunol Neuroinflamm. 2025 Sep; 2025 Jul 18. PMID: 40680247.", + "TB or not TB: That depends on the antibody Fc. Kumar S, O'Connor KC. Sci Immunol. 2025 Jul 4; 2025 Jul 4. PMID: 40614213.", + "Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures. Li H, Pham MC, Teng J, O'Connor KC, Noviello CM, Hibbs RE. Cell. 2025 May 1; 2025 Apr 8. PMID: 40203823.", + "MuSK is a substrate for CaMK2β but this interaction is dispensable for MuSK activation in vivo. Prömer JJ, Wolske S, Castets P, van Woerden GM, Barresi C, O'Connor KC, Herbst R. Sci Rep. 2025 Apr 28; 2025 Apr 28. PMID: 40295530.", + "Permissive central tolerance plus defective peripheral checkpoints license pathogenic memory B cells in CASPR2-antibody encephalitis. Sun B, Fernandes D, Soltys J, Kienzler AK, Paneva S, Harrison R, Ramanathan S, Harrison AL, Makuch M, Fichtner ML, Donat RF, Akdeniz D, Bayuangga H, Im MG, Williams R, Vasconcelos A, Thomsen S, Fower A, Sun R, Fox H, Mgbachi V, Davies A, Tseng M, Handel A, Kelly M, Zhao M, Bancroft J, Bashford-Rogers R, Pluvinage JV, Dandekar R, Alvarenga BD, Dustin LB, Rinaldi S, Owens R, Anthony D, Bennett DL, Waters P, Davis SJ, Wilson MR, O'Connor KC, Carvalho AL, Irani SR. Sci Adv. 2025 Apr 18; 2025 Apr 16. PMID: 40238887.", + "Luck gone cold: A trifecta of B cell mutations associates with cryoglobulinemia. Chen K, O'Connor KC. Sci Immunol. 2025 Apr 4; 2025 Apr 4. PMID: 40184441.", + "Does thymectomy in adults have long-term health consequences? Detterbeck FC, Kaminski HJ, Blasberg JD, O'Connor KC. J Thorac Cardiovasc Surg. 2025 Mar; 2024 Dec 6. PMID: 39641701.", + "Composition and function of AChR chimeric autoantibody receptor T cells for antigen-specific B cell depletion in myasthenia gravis. Oh S, Khani-Habibabadi F, O'Connor KC, Payne AS. Sci Adv. 2025 Feb 28; 2025 Feb 28. PMID: 40020066.", + "Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis. Sun B, Fernandes D, Kienzler AK, Paneva S, Harrison R, Ramanathan S, Harrison AL, Makuch M, Fichtner ML, Donat RF, Akdeniz D, Bayuangga H, Im MG, Williams R, Vasconcelos A, Thomsen S, Fower A, Sun R, Fox H, Mgbachi V, Davies A, Tseng M, Handel A, Kelly M, Zhao M, Bancroft J, Bashford-Rogers R, Pluvinage JV, Dandekar R, Alvarenga BD, Dustin L, Rinaldi S, Owens R, Anthony D, Bennett DL, Waters P, Davis SJ, Wilson MR, O'Connor KC, Soltys J, Carvalho AL, Irani SR. bioRxiv. 2025 Jan 14; 2025 Jan 14. PMID: 39868113.", + "Contribution of cellular immune dysregulation to myasthenia gravis pathology. Bayer AC, Nowak RJ, O'Connor KC. Int Rev Neurobiol. 2025; 2025 May 20. PMID: 40675740.", + "Author Correction: Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells. Oh S, Mao X, Manfredo-Vieira S, Lee J, Patel D, Choi EJ, Alvarado A, Cottman-Thomas E, Maseda D, Tsao PY, Ellebrecht CT, Khella SL, Richman DP, O'Connor KC, Herzberg U, Binder GK, Milone MC, Basu S, Payne AS. Nat Biotechnol. 2024 Dec. PMID: 39543316.", + "Fluorescence-detection size-exclusion chromatography specifically detects autoantibodies targeting the ganglionic acetylcholine receptor in patients with autoimmune autonomic ganglionopathy. Baxter L, Hopkins S, O'Connor KC, Pham MC, Nowak RJ, Monson NL, Blackburn K, Hibbs RE, Vernino S, Noviello CM. J Neuroimmunol. 2024 Nov 15; 2024 Sep 8. PMID: 39277987.", + "Tricky Ts play possum to propagate autoimmune disease. Panicker AJ, O'Connor KC. Sci Immunol. 2024 Oct 4; 2024 Oct 4. PMID: 39365872.", + "B cell and aquaporin-4 antibody relationships with neuromyelitis optica spectrum disorder activity. Bennett JL, Pittock SJ, Paul F, Kim HJ, Irani SR, O'Connor KC, Patterson KR, Smith MA, Gunsior M, Mittereder N, Rees WA, Cimbora D, Cree BAC. Ann Clin Transl Neurol. 2024 Oct; 2024 Sep 2. PMID: 39222408.", + "Hide-&-Go-PhiP-Seq: Finding an elusive predictive MS biomarker. Wallace A, O'Connor KC. Sci Immunol. 2024 Jun 7; 2024 Jun 7. PMID: 38848339.", + "Unveiling the proteome-wide autoreactome enables enhanced evaluation of emerging CAR T cell therapies in autoimmunity. Bodansky A, Yu DJ, Rallistan A, Kalaycioglu M, Boonyaratanakornkit J, Green DJ, Gauthier J, Turtle CJ, Zorn K, O'Donovan B, Mandel-Brehm C, Asaki J, Kortbawi H, Kung AF, Rackaityte E, Wang CY, Saxena A, de Dios K, Masi G, Nowak RJ, O'Connor KC, Li H, Diaz VE, Saloner R, Casaletto KB, Gontrum EQ, Chan B, Kramer JH, Wilson MR, Utz PJ, Hill JA, Jackson SW, Anderson MS, DeRisi JL. J Clin Invest. 2024 May 16; 2024 May 16. PMID: 38753445.", + "A Noncanonical CD56dimCD16dim/- NK Cell Subset Indicative of Prior Cytotoxic Activity Is Elevated in Patients with Autoantibody-Mediated Neurologic Diseases. Yandamuri SS, Filipek B, Lele N, Cohen I, Bennett JL, Nowak RJ, Sotirchos ES, Longbrake EE, Mace EM, O'Connor KC. J Immunol. 2024 Mar 1. PMID: 38251887.", + "Unveiling the autoreactome: Proteome-wide immunological fingerprints reveal the promise of plasma cell depleting therapy. Bodansky A, Yu DJ, Rallistan A, Kalaycioglu M, Boonyaratanakornkit J, Green DJ, Gauthier J, Turtle CJ, Zorn K, O'Donovan B, Mandel-Brehm C, Asaki J, Kortbawi H, Kung AF, Rackaityte E, Wang CY, Saxena A, de Dios K, Masi G, Nowak RJ, O'Connor KC, Li H, Diaz VE, Casaletto KB, Gontrum EQ, Chan B, Kramer JH, Wilson MR, Utz PJ, Hill JA, Jackson SW, Anderson MS, DeRisi JL. medRxiv. 2023 Dec 20; 2023 Dec 20. PMID: 38196603.", + "Remission of severe myasthenia gravis after autologous stem cell transplantation. Schlatter MI, Yandamuri SS, O'Connor KC, Nowak RJ, Pham MC, Obaid AH, Redman C, Provost M, McSweeney PA, Pearlman ML, Tees MT, Bowen JD, Nash RA, Georges GE. Ann Clin Transl Neurol. 2023 Nov; 2023 Sep 19. PMID: 37726935.", + "From drab to Fab; PLP1's fit is redressed for MS. Bayer AC, O'Connor KC. Sci Immunol. 2023 Oct 13; 2023 Oct 6. PMID: 37801515.", + "Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells. Oh S, Mao X, Manfredo-Vieira S, Lee J, Patel D, Choi EJ, Alvarado A, Cottman-Thomas E, Maseda D, Tsao PY, Ellebrecht CT, Khella SL, Richman DP, O'Connor KC, Herzberg U, Binder GK, Milone MC, Basu S, Payne AS. Nat Biotechnol. 2023 Sep; 2023 Jan 19. PMID: 36658341.", + "Toddler's T cells are taught in muco-school. Khani-Habibabadi F, O'Connor KC. Sci Immunol. 2023 Aug 4; 2023 Aug 4. PMID: 37540737.", + "Individual myasthenia gravis autoantibody clones can efficiently mediate multiple mechanisms of pathology. Pham MC, Masi G, Patzina R, Obaid AH, Oxendine SR, Oh S, Payne AS, Nowak RJ, O'Connor KC. Acta Neuropathol. 2023 Aug; 2023 Jun 21. PMID: 37344701.", + "MOGAD patient autoantibodies induce complement, phagocytosis, and cellular cytotoxicity. Yandamuri SS, Filipek B, Obaid AH, Lele N, Thurman JM, Makhani N, Nowak RJ, Guo Y, Lucchinetti CF, Flanagan EP, Longbrake EE, O'Connor KC. JCI Insight. 2023 Jun 8; 2023 Jun 8. PMID: 37097758.", + "The Plasma Cell Infiltrate Populating the Muscle Tissue of Patients with Inclusion Body Myositis Features Distinct B Cell Receptor Repertoire Properties. Jiang R, Roy B, Wu Q, Mohanty S, Nowak RJ, Shaw AC, Kleinstein SH, O'Connor KC. Immunohorizons. 2023 May 1. PMID: 37171806.", + "Clinicoserological insights into patients with immune checkpoint inhibitor-induced myasthenia gravis. Masi G, Pham MC, Karatz T, Oh S, Payne AS, Nowak RJ, Howard JF Jr, Guptill JT, Juel VC, O'Connor KC. Ann Clin Transl Neurol. 2023 May; 2023 Mar 16. PMID: 36924454.", + "Plasmablasts from the past: Nostalgic B cells can't let go. Ohashi SN, O'Connor KC. Sci Immunol. 2023 Mar 10; 2023 Mar 3. PMID: 36867677.", + "SAkuraBONSAI: Protocol design of a novel, prospective study to explore clinical, imaging, and biomarker outcomes in patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorder receiving open-label satralizumab. Bennett JL, Fujihara K, Kim HJ, Marignier R, O'Connor KC, Sergott RC, Traboulsee A, Wiendl H, Wuerfel J, Zamvil SS, Anania VG, Buffels R, Künzel T, Lekkerkerker AN, Lennon-Chrimes S, Pittock SJ. Front Neurol. 2023; 2023 Feb 17. PMID: 36873431.", + "Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy. Fichtner ML, Hoehn KB, Ford EE, Mane-Damas M, Oh S, Waters P, Payne AS, Smith ML, Watson CT, Losen M, Martinez-Martinez P, Nowak RJ, Kleinstein SH, O'Connor KC. Acta Neuropathol Commun. 2022 Oct 28; 2022 Oct 28. PMID: 36307868.", + "EBVerified TCRs and multiple sclerosis. Sefik E, O'Connor KC. Sci Immunol. 2022 Oct 14; 2022 Oct 7. PMID: 36206354.", + "Novel pathophysiological insights in autoimmune myasthenia gravis. Masi G, O'Connor KC. Curr Opin Neurol. 2022 Oct 1; 2022 Aug 4. PMID: 35942663.", + "Inflammatory Responses After Ischemic Stroke. DeLong JH, Ohashi SN, O'Connor KC, Sansing LH. Semin Immunopathol. 2022 Sep; 2022 Jun 29. PMID: 35767089.", + "Heterogeneity of Acetylcholine Receptor Autoantibody-Mediated Complement Activity in Patients With Myasthenia Gravis. Obaid AH, Zografou C, Vadysirisack DD, Munro-Sheldon B, Fichtner ML, Roy B, Philbrick WM, Bennett JL, Nowak RJ, O'Connor KC. Neurol Neuroimmunol Neuroinflamm. 2022 Jul; 2022 Apr 26. PMID: 35473886.", + "The clinical need for clustered AChR cell-based assay testing of seronegative MG. Masi G, Li Y, Karatz T, Pham MC, Oxendine SR, Nowak RJ, Guptill JT, O'Connor KC. J Neuroimmunol. 2022 Jun 15; 2022 Mar 25. PMID: 35366559.", + "Reliability of patient self-reports to clinician-assigned functional scores of inclusion body myositis. Roy B, Zubair A, Petschke K, O'Connor KC, Paltiel AD, Nowak RJ. J Neurol Sci. 2022 May 15; 2022 Mar 15. PMID: 35344793.", + "Myasthenia gravis complement activity is independent of autoantibody titer and disease severity. Fichtner ML, Hoarty MD, Vadysirisack DD, Munro-Sheldon B, Nowak RJ, O'Connor KC. PLoS One. 2022; 2022 Mar 15. PMID: 35290370.", + "Phase 2 Trial of Rituximab in Acetylcholine Receptor Antibody-Positive Generalized Myasthenia Gravis: The BeatMG Study. Nowak RJ, Coffey CS, Goldstein JM, Dimachkie MM, Benatar M, Kissel JT, Wolfe GI, Burns TM, Freimer ML, Nations S, Granit V, Smith AG, Richman DP, Ciafaloni E, Al-Lozi MT, Sams LA, Quan D, Ubogu E, Pearson B, Sharma A, Yankey JW, Uribe L, Shy M, Amato AA, Conwit R, O'Connor KC, Hafler DA, Cudkowicz ME, Barohn RJ. Neurology. 2022 Jan 25; 2022 Jan 25. PMID: 34857535.", + "COVID-19 Vaccination Reactogenicity in Persons With Multiple Sclerosis. Briggs FBS, Mateen FJ, Schmidt H, Currie KM, Siefers HM, Crouthamel S, Bebo BF, Fiol J, Racke MK, O'Connor KC, Kolaczkowski LG, Klein P, Loud S, McBurney RN. Neurol Neuroimmunol Neuroinflamm. 2022 Jan; 2021 Nov 9. PMID: 34753828.", + "GABA-cadabra: autoantibodies trick neurotransmitter receptors and induce seizures. Masi G, O'Connor KC. Sci Immunol. 2021 Dec 3; 2021 Dec 3. PMID: 34860582.", + "Elevated N-Linked Glycosylation of IgG V Regions in Myasthenia Gravis Disease Subtypes. Mandel-Brehm C, Fichtner ML, Jiang R, Winton VJ, Vazquez SE, Pham MC, Hoehn KB, Kelleher NL, Nowak RJ, Kleinstein SH, Wilson MR, DeRisi JL, O'Connor KC. J Immunol. 2021 Oct 15; 2021 Sep 20. PMID: 34544801.", + "Lost in post-translational modification-Dengue virus writes its own sequel. Yandamuri SS, O'Connor KC. Sci Immunol. 2021 Jul 2. PMID: 34215681.", + "Brain tumor T cells inhibited by their natural KLR(B1) instinct. Oxendine S, O'Connor KC. Sci Immunol. 2021 Apr 2. PMID: 33811061.", + "CD4+ follicular regulatory T cells optimize the influenza virus-specific B cell response. Lu Y, Jiang R, Freyn AW, Wang J, Strohmeier S, Lederer K, Locci M, Zhao H, Angeletti D, O'Connor KC, Kleinstein SH, Nachbagauer R, Craft J. J Exp Med. 2021 Mar 1. PMID: 33326020.", + "Affinity maturation is required for pathogenic monovalent IgG4 autoantibody development in myasthenia gravis. Fichtner ML, Vieni C, Redler RL, Kolich L, Jiang R, Takata K, Stathopoulos P, Suarez PA, Nowak RJ, Burden SJ, Ekiert DC, O'Connor KC. J Exp Med. 2020 Dec 7. PMID: 32820331.", + "Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis. Jiang R, Hoehn KB, Lee CS, Pham MC, Homer RJ, Detterbeck FC, Aban I, Jacobson L, Vincent A, Nowak RJ, Kaminski HJ, Kleinstein SH, O'Connor KC. Proc Natl Acad Sci U S A. 2020 Dec 1; 2020 Nov 16. PMID: 33199596.", + "Two mAbs take a stab at influenza's NActive site. Pham MC, O'Connor KC. Sci Immunol. 2020 Nov 6. PMID: 33158977.", + "High-throughput investigation of molecular and cellular biomarkers in NMOSD. Yandamuri SS, Jiang R, Sharma A, Cotzomi E, Zografou C, Ma AK, Alvey JS, Cook LJ, Smith TJ, Yeaman MR, O'Connor KC. Neurol Neuroimmunol Neuroinflamm. 2020 Sep; 2020 Aug 4. PMID: 32753407.", + "The B cell immunobiology that underlies CNS autoantibody-mediated diseases. Sun B, Ramberger M, O'Connor KC, Bashford-Rogers RJM, Irani SR. Nat Rev Neurol. 2020 Sep; 2020 Jul 28. PMID: 32724223.", + "Single-cell repertoire tracing identifies rituximab-resistant B cells during myasthenia gravis relapses. Jiang R, Fichtner ML, Hoehn KB, Pham MC, Stathopoulos P, Nowak RJ, Kleinstein SH, O'Connor KC. JCI Insight. 2020 Jul 23; 2020 Jul 23. PMID: 32573488.", + "Exploring outcomes and characteristics of myasthenia gravis: Rationale, aims and design of registry - The EXPLORE-MG registry. Anil R, Kumar A, Alaparthi S, Sharma A, Nye JL, Roy B, O'Connor KC, Nowak RJ. J Neurol Sci. 2020 Jul 15; 2020 Apr 16. PMID: 32388060.", + "Sweet and low-autoantibodies deny oligodendrocytes their sugar fix. Hernandez AL, O'Connor KC. Sci Immunol. 2020 Jun 5. PMID: 32503879.", + "Autoimmune Pathology in Myasthenia Gravis Disease Subtypes Is Governed by Divergent Mechanisms of Immunopathology. Fichtner ML, Jiang R, Bourke A, Nowak RJ, O'Connor KC. Front Immunol. 2020; 2020 May 27. PMID: 32547535.", + "Impaired B-cell tolerance checkpoints promote the development of autoimmune diseases and pathogenic autoantibodies. Meffre E, O'Connor KC. Immunol Rev. 2019 Nov; 2019 Nov 12. PMID: 31721234.", + "Phenotypic and Ig Repertoire Analyses Indicate a Common Origin of IgD(-)CD27(-) Double Negative B Cells in Healthy Individuals and Multiple Sclerosis Patients. Fraussen J, Marquez S, Takata K, Beckers L, Montes Diaz G, Zografou C, Van Wijmeersch B, Villar LM, O'Connor KC, Kleinstein SH, Somers V. J Immunol. 2019 Sep 15; 2019 Aug 7. PMID: 31391234.", + "Characterization of pathogenic monoclonal autoantibodies derived from muscle-specific kinase myasthenia gravis patients. Takata K, Stathopoulos P, Cao M, Mané-Damas M, Fichtner ML, Benotti ES, Jacobson L, Waters P, Irani SR, Martinez-Martinez P, Beeson D, Losen M, Vincent A, Nowak RJ, O'Connor KC. JCI Insight. 2019 Jun 20; 2019 Jun 20. PMID: 31217355.", + "Early B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production. Cotzomi E, Stathopoulos P, Lee CS, Ritchie AM, Soltys JN, Delmotte FR, Oe T, Sng J, Jiang R, Ma AK, Vander Heiden JA, Kleinstein SH, Levy M, Bennett JL, Meffre E, O'Connor KC. Brain. 2019 Jun 1. PMID: 31056665.", + "Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity. Stathopoulos P, Chastre A, Waters P, Irani S, Fichtner ML, Benotti ES, Guthridge JM, Seifert J, Nowak RJ, Buckner JH, Holers VM, James JA, Hafler DA, O'Connor KC. J Immunol. 2019 Apr 15; 2019 Mar 1. PMID: 30824481.", + "Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients. James JA, Chen H, Young KA, Bemis EA, Seifert J, Bourn RL, Deane KD, Demoruelle MK, Feser M, O'Dell JR, Weisman MH, Keating RM, Gaffney PM, Kelly JA, Langefeld CD, Harley JB, Robinson W, Hafler DA, O'Connor KC, Buckner J, Guthridge JM, Norris JM, Holers VM. EBioMedicine. 2019 Apr; 2019 Apr 3. PMID: 30952617.", + "Identification of Subject-Specific Immunoglobulin Alleles From Expressed Repertoire Sequencing Data. Gadala-Maria D, Gidoni M, Marquez S, Vander Heiden JA, Kos JT, Watson CT, O'Connor KC, Yaari G, Kleinstein SH. Front Immunol. 2019; 2019 Feb 13. PMID: 30814994.", + "Belly-born B cells bathe the brain. Stathopoulos PA, O'Connor KC. Sci Immunol. 2019 Feb 1. PMID: 30709846.", + "B cells drive auto-T cells to the brain. Pappalardo JL, O'Connor KC. Sci Immunol. 2018 Oct 5. PMID: 30291134.", + "Bats are \"blind\" to the deadly effects of viruses. O'Connor KC. Sci Immunol. 2018 Jun 1. PMID: 29858289.", + "B cells in the pathophysiology of myasthenia gravis. Yi JS, Guptill JT, Stathopoulos P, Nowak RJ, O'Connor KC. Muscle Nerve. 2018 Feb; 2017 Sep 30. PMID: 28940642.", + "Mechanisms underlying B cell immune dysregulation and autoantibody production in MuSK myasthenia gravis. Stathopoulos P, Kumar A, Heiden JAV, Pascual-Goñi E, Nowak RJ, O'Connor KC. Ann N Y Acad Sci. 2018 Jan. PMID: 29381221.", + "In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence. Hillmer AT, Sandiego CM, Hannestad J, Angarita GA, Kumar A, McGovern EM, Huang Y, O'Connor KC, Carson RE, O'Malley SS, Cosgrove KP. Mol Psychiatry. 2017 Dec; 2017 Feb 28. PMID: 28242869.", + "Autoantibody-producing plasmablasts after B cell depletion identified in muscle-specific kinase myasthenia gravis. Stathopoulos P, Kumar A, Nowak RJ, O'Connor KC. JCI Insight. 2017 Sep 7; 2017 Sep 7. PMID: 28878127.", + "Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing. Vander Heiden JA, Stathopoulos P, Zhou JQ, Chen L, Gilbert TJ, Bolen CR, Barohn RJ, Dimachkie MM, Ciafaloni E, Broering TJ, Vigneault F, Nowak RJ, Kleinstein SH, O'Connor KC. J Immunol. 2017 Feb 15; 2017 Jan 13. PMID: 28087666.", + "Durability of the Rituximab Response in Acetylcholine Receptor Autoantibody-Positive Myasthenia Gravis. Robeson KR, Kumar A, Keung B, DiCapua DB, Grodinsky E, Patwa HS, Stathopoulos PA, Goldstein JM, O'Connor KC, Nowak RJ. JAMA Neurol. 2017 Jan 1. PMID: 27893014.", + "A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data. Cui A, Di Niro R, Vander Heiden JA, Briggs AW, Adams K, Gilbert T, O'Connor KC, Vigneault F, Shlomchik MJ, Kleinstein SH. J Immunol. 2016 Nov 1; 2016 Oct 5. PMID: 27707999.", + "Compromised fidelity of B-cell tolerance checkpoints in AChR and MuSK myasthenia gravis. Lee JY, Stathopoulos P, Gupta S, Bannock JM, Barohn RJ, Cotzomi E, Dimachkie MM, Jacobson L, Lee CS, Morbach H, Querol L, Shan JL, Vander Heiden JA, Waters P, Vincent A, Nowak RJ, O'Connor KC. Ann Clin Transl Neurol. 2016 Jun; 2016 Apr 27. PMID: 27547772.", + "Evaluation of KIR4.1 as an Immune Target in Multiple Sclerosis. Chastre A, Hafler DA, O'Connor KC. N Engl J Med. 2016 Apr 14. PMID: 27074083.", + "Autoreactive T Cells from Patients with Myasthenia Gravis Are Characterized by Elevated IL-17, IFN-γ, and GM-CSF and Diminished IL-10 Production. Cao Y, Amezquita RA, Kleinstein SH, Stathopoulos P, Nowak RJ, O'Connor KC. J Immunol. 2016 Mar 1; 2016 Jan 29. PMID: 26826242.", + "Current and future immunotherapy targets in autoimmune neurology. Hu MY, Stathopoulos P, O'connor KC, Pittock SJ, Nowak RJ. Handb Clin Neurol. 2016. PMID: 27112694.", + "Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins. Willis SN, Stathopoulos P, Chastre A, Compton SD, Hafler DA, O'Connor KC. Front Immunol. 2015; 2015 Nov 25. PMID: 26648933.", + "Imaging robust microglial activation after lipopolysaccharide administration in humans with PET. Sandiego CM, Gallezot JD, Pittman B, Nabulsi N, Lim K, Lin SF, Matuskey D, Lee JY, O'Connor KC, Huang Y, Carson RE, Hannestad J, Cosgrove KP. Proc Natl Acad Sci U S A. 2015 Oct 6; 2015 Sep 18. PMID: 26385967.", + "Demographic and clinical features of inclusion body myositis in North America. Paltiel AD, Ingvarsson E, Lee DK, Leff RL, Nowak RJ, Petschke KD, Richards-Shubik S, Zhou A, Shubik M, O'Connor KC. Muscle Nerve. 2015 Oct; 2015 Feb 17. PMID: 25557419.", + "Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome. Xu GJ, Kula T, Xu Q, Li MZ, Vernon SD, Ndung'u T, Ruxrungtham K, Sanchez J, Brander C, Chung RT, O'Connor KC, Walker B, Larman HB, Elledge SJ. Science. 2015 Jun 5. PMID: 26045439.", + "B lymphocytes in neuromyelitis optica. Bennett JL, O'Connor KC, Bar-Or A, Zamvil SS, Hemmer B, Tedder TF, von Büdingen HC, Stuve O, Yeaman MR, Smith TJ, Stadelmann C. Neurol Neuroimmunol Neuroinflamm. 2015 Jun; 2015 May 7. PMID: 25977932.", + "(11)C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas. Park E, Gallezot JD, Delgadillo A, Liu S, Planeta B, Lin SF, O'Connor KC, Lim K, Lee JY, Chastre A, Chen MK, Seneca N, Leppert D, Huang Y, Carson RE, Pelletier D. Eur J Nucl Med Mol Imaging. 2015 Jun; 2015 Apr 2. PMID: 25833352.", + "MOG cell-based assay detects non-MS patients with inflammatory neurologic disease. Waters P, Woodhall M, O'Connor KC, Reindl M, Lang B, Sato DK, Juryńczyk M, Tackley G, Rocha J, Takahashi T, Misu T, Nakashima I, Palace J, Fujihara K, Leite MI, Vincent A. Neurol Neuroimmunol Neuroinflamm. 2015 Jun; 2015 Mar 19. PMID: 25821844.", + "Interleukin-10+ regulatory B cells arise within antigen-experienced CD40+ B cells to maintain tolerance to islet autoantigens. Kleffel S, Vergani A, Tezza S, Ben Nasr M, Niewczas MA, Wong S, Bassi R, D'Addio F, Schatton T, Abdi R, Atkinson M, Sayegh MH, Wen L, Wasserfall CH, O'Connor KC, Fiorina P. Diabetes. 2015 Jan; 2014 Sep 3. PMID: 25187361.", + "B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes. Stern JN, Yaari G, Vander Heiden JA, Church G, Donahue WF, Hintzen RQ, Huttner AJ, Laman JD, Nagra RM, Nylander A, Pitt D, Ramanan S, Siddiqui BA, Vigneault F, Kleinstein SH, Hafler DA, O'Connor KC. Sci Transl Med. 2014 Aug 6. PMID: 25100741.", + "pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires. Vander Heiden JA, Yaari G, Uduman M, Stern JN, O'Connor KC, Hafler DA, Vigneault F, Kleinstein SH. Bioinformatics. 2014 Jul 1; 2014 Mar 10. PMID: 24618469.", + "A molecular view of multiple sclerosis and experimental autoimmune encephalitis: what can we learn from the epitope data? Vaughan K, Peters B, O'Connor KC, Martin R, Sette A. J Neuroimmunol. 2014 Feb 15; 2013 Dec 12. PMID: 24365494.", + "Long-term benefit of rituximab in MuSK autoantibody myasthenia gravis patients. Keung B, Robeson KR, DiCapua DB, Rosen JB, O'Connor KC, Goldstein JM, Nowak RJ. J Neurol Neurosurg Psychiatry. 2013 Dec; 2013 Jun 12. PMID: 23761915.", + "Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data. Yaari G, Vander Heiden JA, Uduman M, Gadala-Maria D, Gupta N, Stern JN, O'Connor KC, Hafler DA, Laserson U, Vigneault F, Kleinstein SH. Front Immunol. 2013; 2013 Nov 15. PMID: 24298272.", + "The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells. Fang L, Lowther DE, Meizlish ML, Anderson RC, Bruce JN, Devine L, Huttner AJ, Kleinstein SH, Lee JY, Stern JN, Yaari G, Lovato L, Cronk KM, O'Connor KC. Neuro Oncol. 2013 Nov; 2013 Aug 26. PMID: 23978377.", + "Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing-remitting multiple sclerosis. Van Haren K, Tomooka BH, Kidd BA, Banwell B, Bar-Or A, Chitnis T, Tenembaum SN, Pohl D, Rostasy K, Dale RC, O'Connor KC, Hafler DA, Steinman L, Robinson WH. Mult Scler. 2013 Nov; 2013 Apr 23. PMID: 23612879.", + "The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: a [¹¹C]PBR28 PET study. Hannestad J, DellaGioia N, Gallezot JD, Lim K, Nabulsi N, Esterlis I, Pittman B, Lee JY, O'Connor KC, Pelletier D, Carson RE. Brain Behav Immun. 2013 Oct; 2013 Jul 9. PMID: 23850810.", + "Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. Querol L, Clark PL, Bailey MA, Cotsapas C, Cross AH, Hafler DA, Kleinstein SH, Lee JY, Yaari G, Willis SN, O'Connor KC. Neurology. 2013 Sep 10; 2013 Aug 6. PMID: 23921886.", + "Specific peripheral B cell tolerance defects in patients with multiple sclerosis. Kinnunen T, Chamberlain N, Morbach H, Cantaert T, Lynch M, Preston-Hurlburt P, Herold KC, Hafler DA, O'Connor KC, Meffre E. J Clin Invest. 2013 Jun; 2013 May 15. PMID: 23676463.", + "PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. Larman HB, Laserson U, Querol L, Verhaeghen K, Solimini NL, Xu GJ, Klarenbeek PL, Church GM, Hafler DA, Plenge RM, Nigrovic PA, De Jager PL, Weets I, Martens GA, O'Connor KC, Elledge SJ. J Autoimmun. 2013 Jun; 2013 Mar 13. PMID: 23497938.", + "Autoantibodies produced at the site of tissue damage provide evidence of humoral autoimmunity in inclusion body myositis. Ray A, Amato AA, Bradshaw EM, Felice KJ, DiCapua DB, Goldstein JM, Lundberg IE, Nowak RJ, Ploegh HL, Spooner E, Wu Q, Willis SN, O'Connor KC. PLoS One. 2012; 2012 Oct 5. PMID: 23071619.", + "Cortical injury in multiple sclerosis; the role of the immune system. Walker CA, Huttner AJ, O'Connor KC. BMC Neurol. 2011 Dec 6; 2011 Dec 6. PMID: 22145746.", + "Acute demyelinating disease after oral therapy with herbal extracts. Kostianovsky A, Maskin P, Noriega MM, Soler C, Bonelli I, Riley CS, O'Connor KC, Saubidet CN, Alvarez PA. Case Rep Neurol. 2011 May; 2011 Jun 25. PMID: 21738505.", + "Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. Obermeier B, Lovato L, Mentele R, Brück W, Forne I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O'Connor KC, Dornmair K. J Neuroimmunol. 2011 Apr; 2011 Feb 24. PMID: 21353315.", + "Fichtner, M.L, C. Vieni, Redler, R.L., Kolich L., Jiang, R., Takata, P. Stathopoulos, P. Suarez, R.J. Nowak, S.J. Burden, D.C. Ekiert and K.C. O'Connor (2020). Self-antigen driven affinity maturation is required for pathogenic monovalent IgG4 autoantibody development. BioRxiv doi: https://doi.org/10.1101/2020.03.14.988758", + "Jiang, R., M.L. Fichtner, K.B. Hoehn, P. Stathopoulos, R.J. Nowak, S.H. Kleinstein, K.C. O'Connor (2020). Single-cell repertoire tracing identifies rituximab refractory B cells during myasthenia gravis relapses. BioRxiv doi: https://doi.org/10.1101/840389", + "Fichtner, M.L., Jiang R., Bourke, A., Nowak R.J. and K.C. O'Connor (2020). Autoimmune pathology in myasthenia gravis disease subtypes are governed by divergent mechanisms of immunopathology. Provisionally accepted https://www.frontiersin.org/articles/10.3389/fimmu.2020.00776/abstract", + "", + "Calendar", + "Contact Us", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Oktay Lab", + "lab_url": "https://medicine.yale.edu/lab/oktay/", + "research_bio": "INFORMATION FOR The overarching aim of the Oktay laboratory is to prevent, retard or reverse age- or chemotherapy-induced gamete aging and preserve fertility in human. Our lab focuses on DNA repair andBRCA-related gene function as it relates to gamete aging and fertility preservation. Oktay lab has discovered the role ofBRCAfunction and related ATM-mediated DNA double strand break repair genes in oocyte aging. In addition to translational work on fertility preservation, Oktay laboratory is currently focusing on upstream mechanisms that result in the age-related decline in ATM-mediated DNA DSB repair deficiency in human oocytes. Further, Oktay lab focuses on the molecular mechanisms of oocyte death induced by chemotherapy, aging, as well as other stressors, and the prevention of such death by pharmacological means. Regulation of primordial follicle growth initiation is another focus, where the discoveries in our lab soon should enable us to manipulate how primordial follicle reserve is depleted, slowing down a component of ovarian aging. Reverse engineered, same discoveries may also allow us to grow human primordial folliclesin vitro, without a need for tissue transplantation. Copy Link Oktay lab is a leading NIH-funded laboratory in ovarian biology, aging, and fertility preservation. We first observed that women withBRCA-mutations show low responses to ovarian stimulation. Foloowing these observation we then discovered that oocytes are capable of self repair of chemotherapy-induced DNA double strand breaks (DSBs) via the activation of ATM-mediated DNA DSB repair. As a result, our laboratory gathered more focus onBRCA-mutation carriers as an experiment of nature in ATM-mediated DNA repair deficiency. In astudy published in Science Translational Medicine, we found that the ability to repair DNA DSBs is crucial in the maintenance of ovarian reserve. In the same study, we showed thatBRCA-mutations lead to lower serum AMH levels in women and lower primordial follicle reserve in mice. Our lab also showed that oocytes ofBRCA-mutation carriers gather a higher number of DNA breaks with age. Moreover, we found that a naturally occurring ceramide-induced death inhibitor S1P prevents human primordial follicle death triggered by gonadotoxic chemotherapy agents. Given the common mechanism of oocyte death and dysfunction through DNA damage and ATM-Pathway, we put forward the DNA Repair theory of oocyte aging (Titus et al Sci Transl 2013). This theory explains both the age-induced ovarian reserve decline and decline in oocyte quality (Turan & Oktay, Hum Reprod Update 2021?). This theory and the goal to slow down ovarian aging is being studied with numerous cutting edge techniques including human ovarian xenografting, organ cultures, laser capture, single-oocyte qRT-PCR and RNA-sequencing, single oocyte bisulfite sequencing, RNA-interference in oocytes, gene editing via CRSPR and dCAS9-CRISPR and other molecular approaches. Because of its fertility preservation expertise and access to human organ donor tissue, our laboratory performs majority of its studies with human tissue complemented by clinical translational studies. Mechanistic work is supplemented by rodent and cell culture data when needed. Given its translational character of the laboratory basic and clinical research merges to create innovative treatments to prevent or delay reproductive aging. This includes recent utility of planned ovarian tissue cryopreservation and its perimenopausal transplantation to significantly dela age-at menopause (Oktay KH, Marin L, Petrikovsky B, Terrani M, Babayev SN. Delaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time? Trends Mol Med. 2021 Aug;27(8):753-761. doi: 10.1016/j.molmed.2021.01.005. Epub 2021 Feb 4. PMID: 33549473; PMCID: PMC8427891.) Copy Link Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Pain and Addiction Interaction Neuroscience (PAIN) Lab", + "lab_url": "https://medicine.yale.edu/lab/pain/", + "research_bio": "INFORMATION FOR Copy Link The mission of the Pain and Addiction Interaction Neuroscience (PAIN) Lab is to pioneer new approaches for understanding and treating chronic pain and substance use disorders. We achieve this by integrating behavioral pharmacology, multimodal pain assessment, and advanced clinical trial methods. Our research is dedicated to translating cutting-edge neurobiological insights into innovative, non-opioid therapeutic options. Copy Link To fulfill our mission, we utilize our extensive expertise in Phase 1 and Phase 2 human laboratory studies. These studies are designed to explore the intricate mechanisms of pain and reward, providing a deeper understanding of these complex conditions. Our commitment to integrated care for individuals suffering from pain and addiction allows us to uncover and address the vital connections between chronic pain and addictive behaviors. Our multidisciplinary approach combines behavioral pharmacology with state-of-the-art psychophysical and pharmacokinetic techniques. We employ comprehensive multimodal assessment methods to capture the complexity of human pain and addiction experiences. This enables us to translate our findings into practical and innovative treatment solutions. Copy Link We are closely linked to the VA Connecticut Healthcare System and the Clinical Neuroscience Research Unit (CNRU) at the Connecticut Mental Health Center (CMHC). Through these collaborations, we aim to enhance the lives of those affected by chronic pain and substance use disorders by developing evidence-based, non-opioid interventions. Ongoing research at the PAIN Lab News about the lab and its members. Advancing the knowledge and treatments of chronic pain and substance use disorders is only possible through the generous participation of volunteers and families. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/pain/publications", + "publications": null + }, + { + "lab_name": "Park Lab", + "lab_url": "https://medicine.yale.edu/lab/park/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/park/publications/", + "publications": null + }, + { + "lab_name": "Petersen Lab", + "lab_url": "https://medicine.yale.edu/lab/petersen/", + "research_bio": "INFORMATION FOR Copy Link Our goal is to use novel neuromonitoring techniques to optimize cerebral blood flow following acute neurovascular injury. In the last few years, the lab’s clinical research focus has been preventing neurologic worsening after ischemic stroke and subarachnoid hemorrhage. With active collaborations across the Neurology, Neurosurgery, and Neuroradiology Departments at Yale, as well as with teams at the University of Iowa and Massachusetts General Hospital, Dr. Petersen and the YCVL have successfully published a number of clinically translatable reports that aspire to improve and personalize patient care. Apply to become a Postgraduate Research Associate in the YCVL! Copy Link", + "publications_page": "https://medicine.yale.edu/lab/petersen/publications/", + "publications": [ + "Yale School of Medicine /", + "Neurology /", + "Research Cerebral Hemodyanmics after Large-vessel Occlusion Ischemic Stroke Autoregulation-Oriented Blood Pressure Management in Acute Brain Injury Blood PREssure Augmentation in Large-vessel Occlusion Stroke Study (PRESS)", + "Cerebral Hemodyanmics after Large-vessel Occlusion Ischemic Stroke", + "Autoregulation-Oriented Blood Pressure Management in Acute Brain Injury", + "Blood PREssure Augmentation in Large-vessel Occlusion Stroke Study (PRESS)", + "People", + "Publications Abstracts", + "Abstracts", + "News Gallery", + "Gallery", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Home", + "Publications", + "Abstracts", + "", + "", + "", + "", + "", + "", + "Aggregated postpartum cerebral autoregulatory curves in normotensive individuals, preeclampsia with severe features, and superimposed preeclampsia with severe features. Woolcock H, Katsidoniotaki M, Taliadouros Meng L, Haghighi N, van Wingerden AS, Alian A, Booker WA, Bello NA, Marshall RS, Kougioumtzoglou IA, Petersen NH, Miller EC. Physiol Meas. 2025 Sep 17; 2025 Sep 17. PMID: 40845907.", + "Impact of Nimodipine-Induced Blood Pressure Reductions on Cerebral Autoregulation and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage. Stoehr KA, Bartolome D, Jayasundara S, Thinzar P, Vargas D, Kim J, Magid-Bernstein J, O'Keefe LM, de Havenon A, Hebert R, Matouk C, Sheth KN, Gilmore EJ, Ortega-Gutierrez S, Petersen NH. Neurocrit Care. 2025 Aug 22; 2025 Aug 22. PMID: 40847251.", + "Use of a dedicated open transcarotid access system for neurovascular disease. Sujijantarat N, Renedo D, Antonios J, Koo AB, Amllay A, Nowicki K, Cord BJ, Hebert R, de Havenon A, Sheth KN, Petersen NH, Matouk C. J Neurointerv Surg. 2025 Mar 17; 2025 Mar 17. PMID: 38719442.", + "Anesthetic management for large vessel occlusion acute ischemic stroke with tandem lesions. Farooqui M, Galecio-Castillo M, Hassan AE, Divani AA, Jumaa M, Ribo M, Petersen NH, Abraham MG, Fifi JT, Guerrero WR, Malik A, Siegler JE, Nguyen TN, Sheth SA, Yoo AJ, Linares G, Janjua N, Quispe-Orozco D, Tekle WG, Sabbagh SY, Zaidi SF, Olive Gadea M, Prasad A, Qureshi A, De Leacy RA, Abdalkader M, Salazar-Marioni S, Soomro J, Gordon W, Turabova C, Rodriguez-Calienes A, Vivanco-Suarez J, Mokin M, Yavagal DR, Jovin TG, Ortega-Gutierrez S. J Neurointerv Surg. 2025 Jan 17; 2025 Jan 17. PMID: 38429099.", + "Physiology, Cerebral Autoregulation. Silverman A, Petersen NH. 2025 Jan. PMID: 31985976.", + "Postpartum Blood Pressure Variability and Heart Rate Variability in Preeclampsia. van Wingerden AS, Katsidoniotaki M, Haghighi N, Almonte C, Woolcock Martinez H, Valdes E, Castro P, Alian A, Booker W, Bello NA, Marshall RS, Kougioumtzoglou IA, Petersen NH, Miller EC. Hypertension. 2024 Dec; 2024 Oct 15. PMID: 39403810.", + "Association between intraprocedural drops in blood pressure and infarct growth rate patterns after acute large-vessel occlusions. Galecio-Castillo M, Quispe-Orozco D, Farooqui M, Dajles A, Vivanco-Suarez J, Rodriguez-Calienes A, Prasad A, Begunova L, Petersen NH, Ortega-Gutierrez S. J Neurointerv Surg. 2024 Nov 22; 2024 Nov 22. PMID: 37923382.", + "Endovascular Treatment of Patients With Acute Ischemic Stroke With Tandem Lesions Presenting With Low Alberta Stroke Program Early Computed Tomography Score. Galecio-Castillo M, Farooqui M, Guerrero WR, Ribo M, Hassan AE, Jumaa MA, Divani AA, Abraham MG, Petersen NH, Fifi JT, Malik A, Siegler JE, Nguyen TN, Sheth SA, Linares G, Janjua N, Soomro J, Quispe-Orozco D, Olivé-Gadea M, Tekle WG, Zaidi SF, Sabbagh SY, Barkley T, Prasad A, De Leacy RA, Abdalkader M, Salazar-Marioni S, Gordon W, Turabova C, Rodriguez-Calienes A, Dibas M, Mokin M, Yavagal DR, Yoo AJ, Sarraj A, Jovin TG, Ortega-Gutierrez S. J Am Heart Assoc. 2024 Nov 19; 2024 Nov 7. PMID: 39508172.", + "Mediation Analysis of Acute Carotid Stenting in Tandem Lesions: Effect on Functional Outcome in a Multicenter Registry. Rodriguez Calienes A, Galecio-Castillo M, Petersen NH, Ribo M, Farooqui M, Hassan AE, Jumaa MA, Divani AA, Abraham MG, Fifi JT, Guerrero WR, Malik AM, Siegler JE, Nguyen TN, Sheth S, Yoo AJ, Linares G, Janjua N, Quispe-Orozco D, Lu Y, Vivanco-Suarez J, Dibas M, Mokin M, Yavagal DR, Jovin TG, Ortega-Gutierrez S. Neurology. 2024 Aug 13; 2024 Jul 3. PMID: 38959444.", + "Impact of Therapeutic Interventions on Cerebral Autoregulatory Function Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study. Prasad A, Gilmore EJ, Kim JA, Begunova L, Olexa M, Beekman R, Falcone GJ, Matouk C, Ortega-Gutierrez S, Temkin NR, Barber J, Diaz-Arrastia R, de Havenon A, Petersen NH. Neurocrit Care. 2024 Aug; 2023 Dec 29. PMID: 38158481.", + "Cervical Dissection in Patients With Tandem Lesions Is Associated With Distal Embolism and Lower Recanalization Success. Galecio-Castillo M, Guerrero WR, Hassan AE, Farooqui M, Jumaa MA, Divani AA, Abraham MG, Petersen NH, Fifi JT, Malik AM, Siegler JE, Nguyen TN, Sheth SA, Yoo AJ, Linares G, Janjua N, Quispe-Orozco D, Olivé-Gadea M, Tekle WG, Zaidi SF, Sabbagh SY, Barkley T, Prasad A, De Leacy RA, Abdalkader M, Salazar-Marioni S, Soomro J, Gordon W, Turabova C, Rodriguez-Calienes A, Dibas M, Mokin M, Yavagal DR, Ribo M, Jovin TG, Ortega-Gutierrez S. Stroke. 2024 Jul; 2024 Jun 24. PMID: 38913799.", + "Primary and Secondary Intracerebral Hemorrhage in Pregnant and Nonpregnant Young Adults by SMASH-UP Criteria. Sariyeva M, Haghighi N, Mitchell A, Booker WA, Petersen NH, Shields AD, Ghoshal S, Agarwal S, Park S, Claassen J, Connolly ES, Roh DJ, Miller EC. J Am Heart Assoc. 2024 Apr 2; 2024 Mar 27. PMID: 38533990.", + "Deviation From Personalized Blood Pressure Targets Correlates With Worse Outcome After Successful Recanalization. Zhang Z, Pu Y, Yu L, Bai H, Duan W, Liu X, Nie X, Wen Z, Zheng L, Hu X, Leng X, Pan Y, Petersen NH, Liu L. J Am Heart Assoc. 2024 Apr 2; 2024 Mar 27. PMID: 38533955.", + "Blood Pressure Trajectories and Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke. Katsanos AH, Joundi RA, Palaiodimou L, Ahmed N, Kim JT, Goyal N, Maier IL, de Havenon A, Anadani M, Matusevicius M, Mistry EA, Khatri P, Arthur AS, Sarraj A, Yaghi S, Shoamanesh A, Catanese L, Psychogios MN, Tsioufis K, Malhotra K, Spiotta AM, Sandset EC, Alexandrov AV, Petersen NH, Tsivgoulis G. Hypertension. 2024 Mar; 2024 Jan 2. PMID: 38164751.", + "Uncertainty-aware deep-learning model for prediction of supratentorial hematoma expansion from admission non-contrast head computed tomography scan. Tran AT, Zeevi T, Haider SP, Abou Karam G, Berson ER, Tharmaseelan H, Qureshi AI, Sanelli PC, Werring DJ, Malhotra A, Petersen NH, de Havenon A, Falcone GJ, Sheth KN, Payabvash S. NPJ Digit Med. 2024 Feb 6; 2024 Feb 6. PMID: 38321131.", + "Detection of Intracerebral Hemorrhage Using Low-Field, Portable Magnetic Resonance Imaging in Patients With Stroke. Mazurek MH, Parasuram NR, Peng TJ, Beekman R, Yadlapalli V, Sorby-Adams AJ, Lalwani D, Zabinska J, Gilmore EJ, Petersen NH, Falcone GJ, Sujijantarat N, Matouk C, Payabvash S, Sze G, Schiff SJ, Iglesias JE, Rosen MS, de Havenon A, Kimberly WT, Sheth KN. Stroke. 2023 Nov; 2023 Oct 5. PMID: 37795593.", + "Safety Outcomes of Mechanical Thrombectomy Versus Combined Thrombectomy and Intravenous Thrombolysis in Tandem Lesions. Rodriguez-Calienes A, Galecio-Castillo M, Farooqui M, Hassan AE, Jumaa MA, Divani AA, Ribo M, Abraham M, Petersen NH, Fifi J, Guerrero WR, Malik AM, Siegler JE, Nguyen TN, Yoo AJ, Linares G, Janjua N, Quispe-Orozco D, Tekle WG, Alhajala H, Ikram A, Rizzo F, Qureshi A, Begunova L, Matsouka S, Vigilante N, Salazar-Marioni S, Abdalkader M, Gordon W, Soomro J, Turabova C, Vivanco-Suarez J, Mokin M, Yavagal DR, Jovin T, Sheth S, Ortega-Gutierrez S. Stroke. 2023 Oct; 2023 Aug 21. PMID: 37602387.", + "Association of Blood Pressure Variability With Death and Discharge Destination Among Critically Ill Patients With and Without Stroke. Stulberg EL, Harris BRE, Zheutlin AR, Delic A, Sheibani N, Anadani M, Yaghi S, Petersen NH, de Havenon A. Neurology. 2023 Sep 12; 2023 Jul 24. PMID: 37487742.", + "Clinical and Safety Outcomes of Endovascular Therapy 6 to 24 Hours After Large Vessel Occlusion Ischemic Stroke With Tandem Lesions. Galecio-Castillo M, Farooqui M, Hassan AE, Jumaa MA, Divani AA, Ribo M, Abraham M, Petersen NH, Fifi JT, Guerrero WR, Malik AM, Siegler JE, Nguyen TN, Sheth S, Yoo AJ, Linares G, Janjua N, Quispe-Orozco D, Tekle W, Zaidi SF, Sabbagh SY, Olivé-Gadea M, Barkley T, Leacy R, Sprankle KW, Abdalkader M, Salazar-Marioni S, Soomro J, Gordon W, Turabova C, Vivanco-Suarez J, Rodriguez-Calienes A, Mokin M, Yavagal DR, Jovin T, Ortega-Gutierrez S. J Stroke. 2023 Sep; 2023 Aug 23. PMID: 37607694.", + "Mechanical thrombectomy beyond 24 hours from last known well in tandem lesions: A multicenter cohort study. Rodriguez-Calienes A, Hassan AE, Siegler JE, Galecio-Castillo M, Farooqui M, Jumaa MA, Janjua N, Divani AA, Ribo M, Abraham M, Petersen NH, Fifi J, Guerrero WR, Malik AM, Nguyen TN, Sheth S, Yoo AJ, Linares G, Lu Y, Vivanco-Suarez J, Ortega-Gutierrez S. Interv Neuroradiol. 2023 Aug 29; 2023 Aug 29. PMID: 37642978.", + "Future of Neurology & Technology: Neuroimaging Made Accessible Using Low-Field, Portable MRI. Parasuram NR, Crawford AL, Mazurek MH, Chavva IR, Beekman R, Gilmore EJ, Petersen NH, Payabvash S, Sze G, Eugenio Iglesias J, Omay SB, Matouk C, Longbrake EE, de Havenon A, Schiff SJ, Rosen MS, Kimberly WT, Sheth KN. Neurology. 2023 May 30; 2023 Jan 31. PMID: 36720639.", + "Precision Medicine in Neurocritical Care for Cerebrovascular Disease Cases. Petersen NH, Sheth KN, Jha RM. Stroke. 2023 May; 2023 Feb 15. PMID: 36789774.", + "Reduced-order modeling and analysis of dynamic cerebral autoregulation via diffusion maps. Dos Santos KRM, Katsidoniotaki MI, Miller EC, Petersen NH, Marshall RS, Kougioumtzoglou IA. Physiol Meas. 2023 Apr 12; 2023 Apr 12. PMID: 36963111.", + "Polygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors. Acosta JN, Both CP, Demarais ZS, Conlon CJ, Leasure AC, Torres-Lopez VM, de Havenon A, Petersen NH, Gill TM, Sansing LH, Sheth KN, Falcone GJ. Neurology. 2023 Apr 11; 2023 Jan 23. PMID: 36690452.", + "Temporal profiles of systolic blood pressure variability and neurologic outcomes after endovascular thrombectomy. Prasad A, Kobsa J, Kodali S, Bartolome D, Begunova L, Quispe-Orozco D, Farooqui M, Zevallos C, Ortega-Gutiérrez S, Anadani M, Almallouhi E, Spiotta AM, Giles JA, Keyrouz SG, Kim JT, Maier IL, Liman J, Psychogios MN, Riou-Comte N, Richard S, Gory B, Quintero Wolfe S, Brown PA, Fargen KM, Mistry EA, Fakhri H, Mistry A, Wong KH, Nascimento FA, Kan P, de Havenon A, Sheth KN, Petersen NH. Eur Stroke J. 2022 Dec; 2022 Jun 24. PMID: 36478756.", + "Interaction of Mean Arterial Pressure and Blood Pressure Variability in Critically Ill Brain Injured Patients. de Havenon A, Petersen NH, Stulberg EL, Anadani M, Biffi A, Sheth KN. Stroke. 2022 Dec; 2022 Nov 11. PMID: 36367101.", + "Similar admission NIHSS may represent larger tissue-at-risk in patients with right-sided versus left-sided large vessel occlusion. Mak A, Matouk C, Avery EW, Behland J, Frey D, Madai VI, Vajkoczy P, Malhotra A, Abou Karam A, Sanelli P, Falcone GJ, Petersen NH, Sansing L, Sheth KN, Payabvash S. J Neurointerv Surg. 2022 Oct; 2021 Oct 13. PMID: 34645705.", + "Association of Chronic Kidney Disease With Risk of Intracerebral Hemorrhage. Vanent KN, Leasure AC, Acosta JN, Kuohn LR, Woo D, Murthy SB, Kamel H, Messé SR, Mullen MT, Cohen JB, Cohen DL, Townsend RR, Petersen NH, Sansing LH, Gill TM, Sheth KN, Falcone GJ. JAMA Neurol. 2022 Sep 1. PMID: 35969388.", + "Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke. Yuen MM, Prabhat AM, Mazurek MH, Chavva IR, Crawford A, Cahn BA, Beekman R, Kim JA, Gobeske KT, Petersen NH, Falcone GJ, Gilmore EJ, Hwang DY, Jasne AS, Amin H, Sharma R, Matouk C, Ward A, Schindler J, Sansing L, de Havenon A, Aydin A, Wira C, Sze G, Rosen MS, Kimberly WT, Sheth KN. Sci Adv. 2022 Apr 22; 2022 Apr 20. PMID: 35442729.", + "Blood Pressure Trajectory Groups and Outcome After Endovascular Thrombectomy: A Multicenter Study. Petersen NH, Kodali S, Meng C, Li F, Nguyen CK, Peshwe KU, Strander S, Silverman A, Kimmel A, Wang A, Anadani M, Almallouhi E, Spiotta AM, Kim JT, Giles JA, Keyrouz SG, Farooqui M, Zevallos C, Maier IL, Psychogios MN, Liman J, Riou-Comte N, Richard S, Gory B, Quintero Wolfe S, Brown PA, Fargen KM, Mistry EA, Fakhri H, Mistry AM, Wong KH, de Havenon A, Nascimento FA, Kan P, Matouk C, Ortega-Gutiérrez S, Sheth KN. Stroke. 2022 Apr; 2021 Nov 16. PMID: 34781705.", + "Real-Time Imaging of Aneurysmal Rupture Causing an Isolated Acute Subdural Hematoma. Hong C, Renedo D, Sujijantarat N, Koo A, Falcone GJ, Malhotra A, Petersen NH, Matouk C. Neurology. 2022 Mar 1; 2021 Dec 22. PMID: 34937782.", + "The Utility of Quantitative EEG in Detecting Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage. Baang HY, Chen HY, Herman AL, Gilmore EJ, Hirsch LJ, Sheth KN, Petersen NH, Zafar SF, Rosenthal ES, Westover MB, Kim JA. J Clin Neurophysiol. 2022 Mar 1. PMID: 34510093.", + "Combining Transcranial Doppler and EEG Data to Predict Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. Chen HY, Elmer J, Zafar SF, Ghanta M, Moura Junior V, Rosenthal ES, Gilmore EJ, Hirsch LJ, Zaveri HP, Sheth KN, Petersen NH, Westover MB, Kim JA. Neurology. 2022 Feb 1; 2021 Nov 29. PMID: 34845057.", + "Bedside Assessment of Cerebral Autoregulation: Working Toward a Common Monitoring Standard. Petersen NH. Neurocrit Care. 2022 Feb; 2021 Aug 17. PMID: 34405322.", + "Blood Pressure After Endovascular Thrombectomy and Outcomes in Patients With Acute Ischemic Stroke: An Individual Patient Data Meta-analysis. Katsanos AH, Malhotra K, Ahmed N, Seitidis G, Mistry EA, Mavridis D, Kim JT, Veroniki AA, Maier I, Matusevicius M, Khatri P, Anadani M, Goyal N, Arthur AS, Sarraj A, Yaghi S, Shoamanesh A, Catanese L, Kantzanou M, Psaltopoulou T, Rentzos A, Psychogios M, Van Adel B, Spiotta AM, Sandset EC, de Havenon A, Alexandrov AV, Petersen NH, Tsivgoulis G. Neurology. 2022 Jan 18; 2021 Nov 12. PMID: 34772799.", + "Blood Pressure Management After Endovascular Thrombectomy. Peng TJ, Ortega-Gutiérrez S, de Havenon A, Petersen NH. Front Neurol. 2021; 2021 Sep 3. PMID: 34539562.", + "Direct carotid puncture for mechanical thrombectomy in acute ischemic stroke patients with prohibitive vascular access. Cord BJ, Kodali S, Strander S, Silverman A, Wang A, Chouairi F, Koo AB, Nguyen CK, Peshwe K, Kimmel A, Porto CM, Hebert RM, Falcone GJ, Sheth KN, Sansing LH, Schindler JL, Matouk CC, Petersen NH. J Neurosurg. 2021 Jul 1; 2020 Aug 14. PMID: 32796146.", + "Admission Hemoglobin Levels Are Associated With Functional Outcome in Spontaneous Intracerebral Hemorrhage. Acosta JN, Leasure AC, Kuohn LR, Both CP, Petersen NH, Sansing LH, Matouk CC, Testai F, Langefeld CD, Woo D, Kamel H, Murthy SB, Qureshi A, Mayer SA, Sheth KN, Falcone GJ. Crit Care Med. 2021 May 1. PMID: 33591003.", + "Endovascular thrombectomy in acute ischemic stroke patients with COVID-19: prevalence, demographics, and outcomes. de Havenon A, Yaghi S, Mistry EA, Delic A, Hohmann S, Shippey E, Stulberg E, Tirschwell D, Frontera JA, Petersen NH, Anadani M. J Neurointerv Surg. 2020 Nov; 2020 Sep 28. PMID: 32989032.", + "Editorial Commentary to Article \"The Magnitude of Blood Pressure Reduction Predicts Poor In-hospital Outcome in Acute Intracerebral Hemorrhage\" by Divani et al. Petersen NH. Neurocrit Care. 2020 Oct. PMID: 32638193.", + "Blood pressure reduction and outcome after endovascular therapy with successful reperfusion: a multicenter study. Anadani M, Arthur AS, Alawieh A, Orabi Y, Alexandrov A, Goyal N, Psychogios MN, Maier I, Kim JT, Keyrouz SG, de Havenon A, Petersen NH, Pandhi A, Swisher CB, Inamullah O, Liman J, Kodali S, Giles JA, Allen M, Wolfe SQ, Tsivgoulis G, Cagle BA, Oravec CS, Gory B, De Marini P, Kan P, Rahman S, Richard S, Nascimento FA, Spiotta A. J Neurointerv Surg. 2020 Oct; 2019 Dec 5. PMID: 31806668.", + "Effects of Collateral Status on Infarct Distribution Following Endovascular Therapy in Large Vessel Occlusion Stroke. Al-Dasuqi K, Payabvash S, Torres-Flores GA, Strander SM, Nguyen CK, Peshwe KU, Kodali S, Silverman A, Malhotra A, Johnson MH, Matouk CC, Schindler JL, Sansing LH, Falcone GJ, Sheth KN, Petersen NH. Stroke. 2020 Sep; 2020 Aug 12. PMID: 32781941.", + "Hemodynamics and Hemorrhagic Transformation After Endovascular Therapy for Ischemic Stroke. Silverman A, Kodali S, Sheth KN, Petersen NH. Front Neurol. 2020; 2020 Jul 17. PMID: 32765416.", + "Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage. Falcone GJ, Kirsch E, Acosta JN, Noche RB, Leasure A, Marini S, Chung J, Selim M, Meschia JF, Brown DL, Worrall BB, Tirschwell DL, Jagiella JM, Schmidt H, Jimenez-Conde J, Fernandez-Cadenas I, Lindgren A, Slowik A, Gill D, Holmes M, Phuah CL, Petersen NH, Matouk Md CN, Gunel M, Sansing L, Bennett D, Chen Z, Sun LL, Clarke R, Walters RG, Gill TM, Biffi A, Kathiresan S, Langefeld CD, Woo D, Rosand J, Sheth KN, Anderson CD. Ann Neurol. 2020 Jul; 2020 May 7. PMID: 32277781.", + "Pre-endovascular therapy change in blood pressure is associated with outcomes in patients with stroke. Mistry EA, Dakay K, Petersen NH, Jayaraman M, McTaggart R, Furie K, Mistry A, Mehta T, Arora N, De Los Rios La Rosa F, Starosciak AK, Siegler JE, Barnhill N, Patel K, Assad S, Tarboosh A, Cruz AS, Wagner J, Fortuny E, Bennett A, James RF, Jagadeesan BD, Streib C, Kasner S, Weber S, Chitale RV, Volpi J, Mayer SA, Khatri P, Yaghi S. J Neurol Neurosurg Psychiatry. 2020 Apr; 2020 Feb 6. PMID: 32029540.", + "Fixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke. Petersen NH, Silverman A, Strander SM, Kodali S, Wang A, Sansing LH, Schindler JL, Falcone GJ, Gilmore EJ, Jasne AS, Cord B, Hebert RM, Johnson M, Matouk CC, Sheth KN. Stroke. 2020 Mar; 2020 Feb 12. PMID: 32078493.", + "Poor Outcomes Related to Anterior Extension of Large Hemispheric Infarction: Topographic Analysis of GAMES-RP Trial MRI Scans. Payabvash S, Falcone GJ, Sze GK, Jain A, Beslow LA, Petersen NH, Sheth KN, Kimberly WT. J Stroke Cerebrovasc Dis. 2020 Feb; 2019 Nov 29. PMID: 31787498.", + "Changes on Dynamic Cerebral Autoregulation Are Associated with Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage. Ortega-Gutierrez S, Samaniego EA, Reccius A, Huang A, Zheng-Lin B, Masukar A, Marshall RS, Petersen NH. Acta Neurochir Suppl. 2020. PMID: 31407076.", + "Response by Petersen et al to Letter Regarding Article, \"Decreases in Blood Pressure During Thrombectomy Are Associated With Larger Infarct Volumes and Worse Functional Outcome\". Petersen NH, Silverman A, Kimmel AC, Sheth KN. Stroke. 2019 Nov; 2019 Oct 18. PMID: 31623540.", + "Deviation From Personalized Blood Pressure Targets Is Associated With Worse Outcome After Subarachnoid Hemorrhage. Silverman A, Kodali S, Strander S, Gilmore EJ, Kimmel A, Wang A, Cord B, Falcone G, Hebert R, Matouk C, Sheth KN, Petersen NH. Stroke. 2019 Oct; 2019 Sep 9. PMID: 31495332.", + "Association of Personalized Blood Pressure Targets With Hemorrhagic Transformation and Functional Outcome After Endovascular Stroke Therapy. Petersen NH, Silverman A, Wang A, Strander S, Kodali S, Matouk C, Sheth KN. JAMA Neurol. 2019 Oct 1. PMID: 31355872.", + "Decreases in Blood Pressure During Thrombectomy Are Associated With Larger Infarct Volumes and Worse Functional Outcome. Petersen NH, Ortega-Gutierrez S, Wang A, Lopez GV, Strander S, Kodali S, Silverman A, Zheng-Lin B, Dandapat S, Sansing LH, Schindler JL, Falcone GJ, Gilmore EJ, Amin H, Cord B, Hebert RM, Matouk C, Sheth KN. Stroke. 2019 Jul; 2019 Jun 4. PMID: 31159701.", + "Towards Individualized Blood Pressure Management After Stroke. Petersen NH, Kodali S, Sheth KN. Am J Hypertens. 2019 Feb 12. PMID: 30590406.", + "Long-Term Outcomes in Patients Aged ≤70 Years With Intravenous Glyburide From the Phase II GAMES-RP Study of Large Hemispheric Infarction: An Exploratory Analysis. Sheth KN, Petersen NH, Cheung K, Elm JJ, Hinson HE, Molyneaux BJ, Beslow LA, Sze GK, Simard JM, Kimberly WT. Stroke. 2018 Jun; 2018 May 22. PMID: 29789393.", + "Autoregulation in the Neuro ICU. Wang A, Ortega-Gutierrez S, Petersen NH. Curr Treat Options Neurol. 2018 May 17; 2018 May 17. PMID: 29770889.", + "Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative. Lansky AJ, Messé SR, Brickman AM, Dwyer M, Bart van der Worp H, Lazar RM, Pietras CG, Abrams KJ, McFadden E, Petersen NH, Browndyke J, Prendergast B, Ng VG, Cutlip DE, Kapadia S, Krucoff MW, Linke A, Scala Moy C, Schofer J, van Es GA, Virmani R, Popma J, Parides MK, Kodali S, Bilello M, Zivadinov R, Akar J, Furie KL, Gress D, Voros S, Moses J, Greer D, Forrest JK, Holmes D, Kappetein AP, Mack M, Baumbach A. Eur Heart J. 2018 May 14. PMID: 28171522.", + "Dedicated Afternoon Rounds for ICU Patients' Families and Family Satisfaction With Care. Weber U, Johnson J, Anderson N, Knies AK, Nhundu B, Bautista C, Huang KB, Hamza M, White J, Coppola A, Akgün KM, Greer DM, Marcolini EG, Gilmore EJ, Petersen NH, Timario N, Poskus K, Sheth KN, Hwang DY. Crit Care Med. 2018 Apr. PMID: 29300237.", + "Functional Improvement Among Intracerebral Hemorrhage (ICH) Survivors up to 12 Months Post-injury. Sreekrishnan A, Leasure AC, Shi FD, Hwang DY, Schindler JL, Petersen NH, Gilmore EJ, Kamel H, Sansing LH, Greer DM, Sheth KN. Neurocrit Care. 2017 Dec. PMID: 28685394.", + "Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative. Lansky AJ, Messé SR, Brickman AM, Dwyer M, van der Worp HB, Lazar RM, Pietras CG, Abrams KJ, McFadden E, Petersen NH, Browndyke J, Prendergast B, Ng VG, Cutlip DE, Kapadia S, Krucoff MW, Linke A, Moy CS, Schofer J, van Es GA, Virmani R, Popma J, Parides MK, Kodali S, Bilello M, Zivadinov R, Akar J, Furie KL, Gress D, Voros S, Moses J, Greer D, Forrest JK, Holmes D, Kappetein AP, Mack M, Baumbach A. J Am Coll Cardiol. 2017 Feb 14. PMID: 28183511.", + "Intracerebral Hemorrhage Location and Functional Outcomes of Patients: A Systematic Literature Review and Meta-Analysis. Sreekrishnan A, Dearborn JL, Greer DM, Shi FD, Hwang DY, Leasure AC, Zhou SE, Gilmore EJ, Matouk CC, Petersen NH, Sansing LH, Sheth KN. Neurocrit Care. 2016 Dec. PMID: 27160888.", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Pi Lab", + "lab_url": "https://medicine.yale.edu/lab/pi/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/pi/publications", + "publications": null + }, + { + "lab_name": "Pierce Lab", + "lab_url": "https://medicine.yale.edu/lab/pierce/", + "research_bio": "INFORMATION FOR Our passion is to understand blood vessel dysfunction in the setting of critical illness. Blood vessels, and the endothelial cells that line them, extend to within micron of all the cells in the human body. Blood vessels regulate blood volume, flow and fluidity as well as immune and platelet activation. To understand how these processes break down in the setting of critical illness we must understand the fundamental biology of endothelial cells and care for the sickest patients. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/pierce/publications", + "publications": null + }, + { + "lab_name": "Pillai Lab", + "lab_url": "https://medicine.yale.edu/lab/pillai/", + "research_bio": "INFORMATION FOR Welcome to the Pillai Laboratory at the Section of Medical Oncology and Hematology, Yale Cancer Center and Dept of Medicine, Yale School of Medicine. The Pillai Lab investigates the molecular and biochemical mechanisms that govern hematopoiesis—the process of blood cell production—in both healthy and disease states. Adult hematopoiesis is a highly complex and dynamic process, and our research focuses on the pivotal role of RNA processing in orchestrating this cascade. We combine genome-wide and transcriptome-wide approaches with classical hematopoietic assays to uncover how RNA regulation contributes to normal blood formation and how its dysregulation drives disease. Copy Link Presented by Integrative Medicine & Support Services at Smilow Cancer Hospital Yale Cancer Center Sponsor Yale Cancer Center/Smilow North Haven Sponsors Yale Cancer Center Sponsors Yale Cancer Center Sponsors Yale Cancer Center Sponsors Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Pitt Lab", + "lab_url": "https://medicine.yale.edu/lab/pitt/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "PittLab", + "lab_url": "https://medicine.yale.edu/lab/pittlab/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Pitzer Lab", + "lab_url": "https://medicine.yale.edu/lab/pitzer/", + "research_bio": "INFORMATION FOR Our research focuses on mathematical modeling of infectious diseases, with a special emphasis on the transmission dynamics of enteric diseases. We use mathematical models to examine the drivers underlying patterns of disease in the population, and to predict the potential population-level impact of intOur research focuses on mathematical modeling of infectious diseases, with a special emphasis on the transmission dynamics of vaccine-preventable and enteric diseases. We use mathematical models to examine the drivers underlying patterns of disease in the population, and to predict the potential population-level impact of interventions such as vaccination and improvements in sanitation. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Polimanti Lab", + "lab_url": "https://medicine.yale.edu/lab/polimanti/", + "research_bio": "INFORMATION FOR Our group is conducting research across multiple domains including Human Genetics, Biological Psychiatry, Evolutionary Biology, Statistical Genetics, and Computational Biology. The overarching goal of our efforts is to understand the link between the human genome and phenome from multiple perspectives. We are part of the Yale Psychiatry Division of Human Genetics, the Yale Department of Biomedical Informatics & Data Science, the Yale Department of Chronic Disease Epidemiology, and the Veterans Affairs Clinical Epidemiology Research Center. Our ongoing studies are currently funded by the National Institute on Drug Abuse, the National Institute on Mental Health, the Department of the Veterans Affairs, One Mind, and the American Foundation for Suicide Prevention. Additionally, we are also involved in large collaborative projects including the Psychiatric Genomics Consortium, the Million Veteran Program, and COVID-19 Host Genetic Initiative. We are always looking forward to recruiting enthusiastic and curious scientists. Get in touch to learn more about current opportunities to support potential trainees. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/polimanti/publications/", + "publications": [ + "Yale School of Medicine /", + "Psychiatry /", + "People", + "Contact", + "Publications", + "Photos", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "People", + "Publications", + "Photos", + "News", + "Contact", + "", + "", + "", + "", + "", + "", + "Understanding the Comorbidities Among Psychiatric Disorders, Chronic Low Back Pain, and Spinal Degenerative Disease Using Observational and Genetically Informed Analyses. Qiu D, Friligkou E, He J, Cabrera-Mendoza B, Aslan M, Gupta M, Polimanti R. Biol Psychiatry Glob Open Sci. 2025 Nov; 2025 Aug 11. PMID: 41036474.", + "The landscape of suicide risk factors in Latin America. Cabrera-Mendoza B, Fries GR, Polimanti R. Psychiatry Res. 2025 Sep; 2025 Jun 16. PMID: 40674133.", + "Epigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses. Pathak GA, Pietrzak RH, Lacobelle A, Overstreet C, Wendt FR, Deak JD, Friligkou E, Nunez YZ, Montalvo-Ortiz JL, Levey DF, Kranzler HR, Gelernter J, Polimanti R. Mol Psychiatry. 2025 Sep; 2025 Apr 17. PMID: 40247127.", + "Age-, sex-, and ancestry-specific prevalence of hearing loss in UK Biobank and All of Us Research Program. He J, Curhan SG, Curhan GC, Polimanti R. Aging Dis. 2025 Jul 16; 2025 Jul 16. PMID: 40681351.", + "Integration of Metabolomic and Brain Imaging Data Highlights Pleiotropy Among Posttraumatic Stress Disorder, Glycoprotein Acetyls, and Pallidum Structure. Løkhammer S, Tesfaye M, Cabrera-Mendoza B, Sandås K, Pathak GA, Friligkou E, Le Hellard S, Polimanti R. Biol Psychiatry Glob Open Sci. 2025 Jul; 2025 Mar 17. PMID: 40270839.", + "Integrating genome-wide information and wearable device data to explore the link of anxiety and antidepressants with pulse rate variability. Friligkou E, Koller D, Pathak GA, Miller EJ, Lampert R, Stein MB, Polimanti R. Mol Psychiatry. 2025 Jun; 2024 Nov 18. PMID: 39558002.", + "Unraveling the genetics of gulf war illness in diverse participants enrolled in the million veteran program. Pathak GA, Koller D, Cabrera-Mendoza B, Nono Djotsa ABS, Wendt FR, De Lillo A, Friligkou E, He J, Kouakou MR, Duong LM, Vahey J, Steele L, Quaden R, Harrington KM, Ahmed ST, Gaziano JM, Concato J, Zhao H, Radhakrishnan K, Gelernter J, Gifford E, Aslan M, Helmer DA, Hauser ER, Polimanti R. Hum Mol Genet. 2025 May 14; 2025 May 14. PMID: 40366759.", + "Characterizing pleiotropy among bipolar disorder, schizophrenia, and major depression: a genome-wide cross-disorder meta-analysis. Friligkou E, Pathak GA, Tylee DS, De Lillo A, Koller D, Cabrera-Mendoza B, Polimanti R. Psychol Med. 2025 May 13; 2025 May 13. PMID: 40357923.", + "Sex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias. He J, Cabrera-Mendoza B, Friligkou E, Mecca AP, van Dyck CH, Pathak GA, Polimanti R. Alzheimers Dement. 2025 May. PMID: 40421744.", + "Observational and Genetic Analyses of Traumatic Experiences and Endometriosis. Koller D, Løkhammer S, Goroshchuk O, Denner V, Stiltner B, Mitjans M, He J, Taylor HS, Lawn RB, Koenen KC, Polimanti R. JAMA Psychiatry. 2025 Apr 1. PMID: 39908042.", + "Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors. Deiana G, He J, Cabrera-Mendoza B, Ciccocioppo R, Napolioni V, Polimanti R. Transl Psychiatry. 2025 Feb 20; 2025 Feb 20. PMID: 39979292.", + "Genetically Informed Study Highlights Income-Independent Effect of Schizophrenia Liability on Mental and Physical Health. Kouakou MR, Cabrera-Mendoza B, Pathak GA, Cannon TD, Polimanti R. Schizophr Bull. 2024 Dec 20. PMID: 38848523.", + "Identifying Genetically Inferred Effects Linking Posttraumatic Stress Disorder to Women's Health, Lipid Disorders, and Malaria Medications. Pathak GA, Wendt FR, Maihofer AX, Ressler KJ, Stein MB, Koenen KC, Nievergelt CM, Polimanti R. Am J Psychiatry. 2024 Dec 1; 2024 Oct 9. PMID: 39380377.", + "Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation. He J, Cabrera-Mendoza B, De Angelis F, Pathak GA, Koller D, Curhan SG, Curhan GC, Mecca AP, van Dyck CH, Polimanti R. Brain. 2024 Oct 3. PMID: 38454550.", + "Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study. Friligkou E, Løkhammer S, Cabrera-Mendoza B, Shen J, He J, Deiana G, Zanoaga MD, Asgel Z, Pilcher A, Di Lascio L, Makharashvili A, Koller D, Tylee DS, Pathak GA, Polimanti R. Nat Genet. 2024 Oct; 2024 Sep 18. PMID: 39294497.", + "Association patterns of antisocial personality disorder across substance use disorders. Low A, Stiltner B, Nunez YZ, Adhikari K, Deak JD, Pietrzak RH, Kranzler HR, Gelernter J, Polimanti R. Transl Psychiatry. 2024 Aug 28; 2024 Aug 28. PMID: 39198385.", + "Estimating the direct effects of the genetic liabilities to bipolar disorder, schizophrenia, and behavioral traits on suicide attempt using a multivariable Mendelian randomization approach. Cabrera-Mendoza B, Aydin N, Fries GR, Docherty AR, Walss-Bass C, Polimanti R. Neuropsychopharmacology. 2024 Aug; 2024 Feb 23. PMID: 38396255.", + "Using Medical Records to Investigate the Genetics of Treatment-Resistant Depression Across Health Care Systems. Polimanti R. Am J Psychiatry. 2024 Jul 1. PMID: 38946279.", + "Distinguishing vulnerability and resilience to posttraumatic stress disorder evaluating traumatic experiences, genetic risk and electronic health records. Løkhammer S, Koller D, Wendt FR, Choi KW, He J, Friligkou E, Overstreet C, Gelernter J, Hellard SL, Polimanti R. Psychiatry Res. 2024 Jul; 2024 May 8. PMID: 38744179.", + "Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders. Koller D, Friligkou E, Stiltner B, Pathak GA, Løkhammer S, Levey DF, Zhou H, Hatoum AS, Deak JD, Kember RL, Treur JL, Kranzler HR, Johnson EC, Stein MB, Gelernter J, Polimanti R. Mol Psychiatry. 2024 Jul; 2024 Feb 15. PMID: 38355787.", + "Unraveling COVID-19 relationship with anxiety disorders and symptoms using genome-wide data. Asgel Z, Kouakou MR, Koller D, Pathak GA, Cabrera-Mendoza B, Polimanti R. J Affect Disord. 2024 May 1; 2024 Feb 19. PMID: 38382819.", + "The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits. Cabrera-Mendoza B, Wendt FR, Pathak GA, Yengo L, Polimanti R. Nat Hum Behav. 2024 May; 2024 Feb 16. PMID: 38366106.", + "Brainwide Mendelian Randomization Study of Anxiety Disorders and Symptoms. Zanoaga MD, Friligkou E, He J, Pathak GA, Koller D, Cabrera-Mendoza B, Stein MB, Polimanti R. Biol Psychiatry. 2024 Apr 15; 2023 Nov 14. PMID: 37967698.", + "Clinical spectrum of Transthyretin amyloidogenic mutations among diverse population origins. De Lillo A, Pathak GA, Low A, De Angelis F, Abou Alaiwi S, Miller EJ, Fuciarelli M, Polimanti R. Hum Genomics. 2024 Mar 25; 2024 Mar 25. PMID: 38523305.", + "Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders. Koller D, Mitjans M, Kouakou M, Friligkou E, Cabrera-Mendoza B, Deak JD, Llonga N, Pathak GA, Stiltner B, Løkhammer S, Levey DF, Zhou H, Hatoum AS, Kember RL, Kranzler HR, Stein MB, Corominas R, Demontis D, Artigas MS, Ramos-Quiroga JA, Gelernter J, Ribasés M, Cormand B, Polimanti R. Psychiatry Res. 2024 Mar; 2024 Feb 3. PMID: 38335780.", + "A perspective on translating genomic discoveries into targets for brain-machine interface and deep brain stimulation devices. Valentim WL, Tylee DS, Polimanti R. WIREs Mech Dis. 2024 Mar-Apr; 2023 Dec 7. PMID: 38059513.", + "Genetic Liability to Posttraumatic Stress Disorder Symptoms and Its Association With Cardiometabolic and Respiratory Outcomes. Pathak GA, Singh K, Choi KW, Fang Y, Kouakou MR, Lee YH, Zhou X, Fritsche LG, Wendt FR, Davis LK, Polimanti R. JAMA Psychiatry. 2024 Jan 1. PMID: 37910111.", + "Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder. Stiltner B, Pietrzak RH, Tylee DS, Nunez YZ, Adhikari K, Kranzler HR, Gelernter J, Polimanti R. iScience. 2023 Aug 18; 2023 Jul 16. PMID: 37554454.", + "Enrichment of self-domestication and neural crest function loci in the heritability of neurodevelopmental disorders. Koller D, Benítez-Burraco A, Polimanti R. Hum Genet. 2023 Aug; 2023 Mar 17. PMID: 36930228.", + "Phenome-wide genetic-correlation analysis and genetically informed causal inference of amyotrophic lateral sclerosis. D'Antona S, Pathak GA, Koller D, Porro D, Cava C, Polimanti R. Hum Genet. 2023 Aug; 2023 Feb 11. PMID: 36773064.", + "Characterizing the polygenic architecture of complex traits in populations of East Asian and European descent. De Lillo A, Wendt FR, Pathak GA, Polimanti R. Hum Genomics. 2023 Jul 20; 2023 Jul 20. PMID: 37475089.", + "Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program. Wendt FR, Pathak GA, Vahey J, Qin X, Koller D, Cabrera-Mendoza B, Haeny A, Harrington KM, Rajeevan N, Duong LM, Levey DF, De Angelis F, De Lillo A, Bigdeli TB, Pyarajan S, Gaziano JM, Gelernter J, Aslan M, Provenzale D, Helmer DA, Hauser ER, Polimanti R. Hum Genomics. 2023 Jun 2; 2023 Jun 2. PMID: 37268996.", + "Sex differences in the polygenic architecture of hearing problems in adults. De Angelis F, Zeleznik OA, Wendt FR, Pathak GA, Tylee DS, De Lillo A, Koller D, Cabrera-Mendoza B, Clifford RE, Maihofer AX, Nievergelt CM, Curhan GC, Curhan SG, Polimanti R. Genome Med. 2023 May 11; 2023 May 11. PMID: 37165447.", + "Sex-Specific Genetic and Transcriptomic Liability to Neuroticism. Wendt FR, Pathak GA, Singh K, Stein MB, Koenen KC, Krystal JH, Gelernter J, Davis LK, Polimanti R. Biol Psychiatry. 2023 Feb 1; 2022 Aug 5. PMID: 36244801.", + "Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders. Koller D, Pathak GA, Wendt FR, Tylee DS, Levey DF, Overstreet C, Gelernter J, Taylor HS, Polimanti R. JAMA Netw Open. 2023 Jan 3; 2023 Jan 3. PMID: 36652249.", + "Phenome-wide association study of loci harboring de novo tandem repeat mutations in UK Biobank exomes. Wendt FR, Pathak GA, Polimanti R. Nat Commun. 2022 Dec 12; 2022 Dec 12. PMID: 36509785.", + "Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations. Koller D, Wendt FR, Pathak GA, De Lillo A, De Angelis F, Cabrera-Mendoza B, Tucci S, Polimanti R. BMC Biol. 2022 Nov 7; 2022 Nov 7. PMID: 36344982.", + "The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study. Cabrera-Mendoza B, Wendt FR, Pathak GA, De Angelis F, De Lillo A, Koller D, Polimanti R. Int J Epidemiol. 2022 Oct 13. PMID: 35751636.", + "Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records. Polimanti R, Wendt FR, Pathak GA, Tylee DS, Tcheandjieu C, Hilliard AT, Levey DF, Adhikari K, Gaziano JM, O'Donnell CJ, Assimes TL, Stein MB, Gelernter J. Mol Psychiatry. 2022 Oct; 2022 Aug 19. PMID: 35986173.", + "Not Only Gene Discovery: Genome-wide Association Studies and Polygenic Risk Scores as Tools to Dissect the Heterogeneity of Major Depressive Disorder. Polimanti R. Biol Psychiatry. 2022 Aug 1. PMID: 35835505.", + "An Atlas of Genetic Correlations and Genetically Informed Associations Linking Psychiatric and Immune-Related Phenotypes. Tylee DS, Lee YK, Wendt FR, Pathak GA, Levey DF, De Angelis F, Gelernter J, Polimanti R. JAMA Psychiatry. 2022 Jul 1. PMID: 35507366.", + "From Evolutionary History to the Concepts of Race and Ancestry: Shifting Our Perspective in Clinical Research. Haeny AM, Polimanti R. Biol Psychiatry. 2022 Jun 15; 2022 Apr 26. PMID: 35483984.", + "The integration of genetically-regulated transcriptomics and electronic health records highlights a pattern of medical outcomes related to increased hepatic transthyretin expression. Pathak GA, De Lillo A, Wendt FR, De Angelis F, Koller D, Cabrera Mendoza B, Jacoby D, Miller EJ, Buxbaum JN, Polimanti R. Amyloid. 2022 Jun; 2021 Dec 22. PMID: 34935565.", + "Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder. Wendt FR, Pathak GA, Deak JD, De Angelis F, Koller D, Cabrera-Mendoza B, Lebovitch DS, Levey DF, Stein MB, Kranzler HR, Koenen KC, Gelernter J, Huckins LM, Polimanti R. Mol Psychiatry. 2022 Apr; 2022 Feb 18. PMID: 35181757.", + "Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events. Wendt FR, Warrier V, Pathak GA, Koenen KC, Stein MB, Krystal JH, Pietrzak RH, Gelernter J, Goldfarb EV, Baron-Cohen S, Polimanti R. Neurobiol Stress. 2022 Mar; 2022 Feb 21. PMID: 35242894.", + "Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. Pathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O' Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. Mol Psychiatry. 2022 Mar; 2022 Mar 3. PMID: 35241783.", + "Host Genetic Liability for Severe COVID-19 Associates with Alcohol Drinking Behavior and Diabetic Outcomes in Participants of European Descent. Wendt FR, De Lillo A, Pathak GA, De Angelis F, Polimanti R. Front Genet. 2021; 2021 Dec 13. PMID: 34966408.", + "Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic risk. De Angelis F, Wendt FR, Pathak GA, Tylee DS, Goswami A, Gelernter J, Polimanti R. Transl Psychiatry. 2021 Nov 13; 2021 Nov 13. PMID: 34775470.", + "Disentangling sex differences in the shared genetic architecture of posttraumatic stress disorder, traumatic experiences, and social support with body size and composition. Muniz Carvalho C, Wendt FR, Pathak GA, Maihofer AX, Stein DJ, Sumner JA, Hemmings SMJ, Nievergelt CM, Koenen KC, Gelernter J, Belangero SI, Polimanti R. Neurobiol Stress. 2021 Nov; 2021 Sep 17. PMID: 34611531.", + "Genetics of substance use disorders in the era of big data. Gelernter J, Polimanti R. Nat Rev Genet. 2021 Nov; 2021 Jul 1. PMID: 34211176.", + "Posttraumatic stress disorder: from gene discovery to disease biology. Polimanti R, Wendt FR. Psychol Med. 2021 Oct; 2021 Feb 15. PMID: 33583458.", + "Biobank Scale Pharmacogenomics Informs the Genetic Underpinnings of Simvastatin Use. Wendt FR, Koller D, Pathak GA, Jacoby D, Miller EJ, Polimanti R. Clin Pharmacol Ther. 2021 Sep; 2021 Apr 30. PMID: 33837531.", + "ACE2 Netlas: In silico Functional Characterization and Drug-Gene Interactions of ACE2 Gene Network to Understand Its Potential Involvement in COVID-19 Susceptibility. Pathak GA, Wendt FR, Goswami A, Koller D, De Angelis F, Polimanti R. Front Genet. 2021; 2021 Aug 27. PMID: 34512723.", + "Cross-ancestry genome-wide association studies identified heterogeneous loci associated with differences of allele frequency and regulome tagging between participants of European descent and other ancestry groups from the UK Biobank. De Lillo A, D'Antona S, Pathak GA, Wendt FR, De Angelis F, Fuciarelli M, Polimanti R. Hum Mol Genet. 2021 Jul 9. PMID: 33890984.", + "Role of microbes in the pathogenesis of neuropsychiatric disorders. Goswami A, Wendt FR, Pathak GA, Tylee DS, De Angelis F, De Lillo A, Polimanti R. Front Neuroendocrinol. 2021 Jul; 2021 May 4. PMID: 33957173.", + "Pleiotropic effects of telomere length loci with brain morphology and brain tissue expression. Pathak GA, Wendt FR, Levey DF, Mecca AP, van Dyck CH, Gelernter J, Polimanti R. Hum Mol Genet. 2021 Jun 26. PMID: 33831179.", + "Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality. Wendt FR, Pathak GA, Levey DF, Nuñez YZ, Overstreet C, Tyrrell C, Adhikari K, De Angelis F, Tylee DS, Goswami A, Krystal JH, Abdallah CG, Stein MB, Kranzler HR, Gelernter J, Polimanti R. Neurobiol Stress. 2021 May; 2021 Feb 18. PMID: 33665242.", + "Dissecting the genetic association of C-reactive protein with PTSD, traumatic events, and social support. Muniz Carvalho C, Wendt FR, Maihofer AX, Stein DJ, Stein MB, Sumner JA, Hemmings SMJ, Nievergelt CM, Koenen KC, Gelernter J, Belangero SI, Polimanti R. Neuropsychopharmacology. 2021 May; 2020 Mar 16. PMID: 32179874.", + "Multivariate genome-wide analysis of education, socioeconomic status and brain phenome. Wendt FR, Pathak GA, Lencz T, Krystal JH, Gelernter J, Polimanti R. Nat Hum Behav. 2021 Apr; 2020 Dec 21. PMID: 33349686.", + "Epigenomic Profiles of African-American Transthyretin Val122Ile Carriers Reveals Putatively Dysregulated Amyloid Mechanisms. Pathak GA, Wendt FR, De Lillo A, Nunez YZ, Goswami A, De Angelis F, Fuciarelli M, Kranzler HR, Gelernter J, Polimanti R. Circ Genom Precis Med. 2021 Feb; 2021 Jan 11. PMID: 33428857.", + "Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality. Polimanti R, Levey DF, Pathak GA, Wendt FR, Nunez YZ, Ursano RJ, Kessler RC, Kranzler HR, Stein MB, Gelernter J. Transl Psychiatry. 2021 Jan 11; 2021 Jan 11. PMID: 33431810.", + "Characterizing the effect of background selection on the polygenicity of brain-related traits. Wendt FR, Pathak GA, Overstreet C, Tylee DS, Gelernter J, Atkinson EG, Polimanti R. Genomics. 2021 Jan; 2020 Dec 2. PMID: 33278486.", + "Epigenetic profiling of Italian patients identified methylation sites associated with hereditary transthyretin amyloidosis. De Lillo A, Pathak GA, De Angelis F, Di Girolamo M, Luigetti M, Sabatelli M, Perfetto F, Frusconi S, Manfellotto D, Fuciarelli M, Polimanti R. Clin Epigenetics. 2020 Nov 17; 2020 Nov 17. PMID: 33203445.", + "Introducing Complex Psychiatry. Gelernter J, Polimanti R. Complex Psychiatry. 2020 Oct; 2020 May 14. PMID: 34883505.", + "Polygenic risk for autism spectrum disorder associates with anger recognition in a neurodevelopment-focused phenome-wide scan of unaffected youths from a population-based cohort. Wendt FR, Carvalho CM, Pathak GA, Gelernter J, Polimanti R. PLoS Genet. 2020 Sep; 2020 Sep 17. PMID: 32941431.", + "Phenotypic and Molecular Characterization of Risk Loci Associated With Asthma and Lung Function. Karaca M, Atceken N, Karaca Ş, Civelek E, Şekerel BE, Polimanti R. Allergy Asthma Immunol Res. 2020 Sep. PMID: 32638561.", + "Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium. Polimanti R, Walters RK, Johnson EC, McClintick JN, Adkins AE, Adkins DE, Bacanu SA, Bierut LJ, Bigdeli TB, Brown S, Bucholz KK, Copeland WE, Costello EJ, Degenhardt L, Farrer LA, Foroud TM, Fox L, Goate AM, Grucza R, Hack LM, Hancock DB, Hartz SM, Heath AC, Hewitt JK, Hopfer CJ, Johnson EO, Kendler KS, Kranzler HR, Krauter K, Lai D, Madden PAF, Martin NG, Maes HH, Nelson EC, Peterson RE, Porjesz B, Riley BP, Saccone N, Stallings M, Wall TL, Webb BT, Wetherill L, Edenberg HJ, Agrawal A, Gelernter J. Mol Psychiatry. 2020 Aug; 2020 Feb 26. PMID: 32099098.", + "Heterogeneity and Polygenicity in Psychiatric Disorders: A Genome-Wide Perspective. Wendt FR, Pathak GA, Tylee DS, Goswami A, Polimanti R. Chronic Stress (Thousand Oaks). 2020 Jan-Dec; 2020 May 18. PMID: 32518889.", + "Investigating Causality Between Blood Metabolites and Emotional and Behavioral Responses to Traumatic Stress: a Mendelian Randomization Study. Carvalho CM, Wendt FR, Stein DJ, Stein MB, Gelernter J, Belangero SI, Polimanti R. Mol Neurobiol. 2020 Mar; 2019 Nov 30. PMID: 31786776.", + "Phenome-wide association study of TTR and RBP4 genes in 361,194 individuals reveals novel insights in the genetics of hereditary and wildtype transthyretin amyloidoses. De Lillo A, De Angelis F, Di Girolamo M, Luigetti M, Frusconi S, Manfellotto D, Fuciarelli M, Polimanti R. Hum Genet. 2019 Dec; 2019 Oct 29. PMID: 31659433.", + "Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders. Wendt FR, Muniz Carvalho C, Pathak GA, Gelernter J, Polimanti R. J Clin Med. 2019 Nov 21; 2019 Nov 21. PMID: 31766499.", + "Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder: A Mendelian Randomization Study. Polimanti R, Ratanatharathorn A, Maihofer AX, Choi KW, Stein MB, Morey RA, Logue MW, Nievergelt CM, Stein DJ, Koenen KC, Gelernter J. JAMA Netw Open. 2019 May 3; 2019 May 3. PMID: 31050786.", + "Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium. Polimanti R, Peterson RE, Ong JS, MacGregor S, Edwards AC, Clarke TK, Frank J, Gerring Z, Gillespie NA, Lind PA, Maes HH, Martin NG, Mbarek H, Medland SE, Streit F, Agrawal A, Edenberg HJ, Kendler KS, Lewis CM, Sullivan PF, Wray NR, Gelernter J, Derks EM. Psychol Med. 2019 May; 2019 Apr 1. PMID: 30929657.", + "Increased Risk of Multiple Outpatient Surgeries in African-American Carriers of Transthyretin Val122Ile Mutation Is Modulated by Non-Coding Variants. Polimanti R, Nuñez YZ, Gelernter J. J Clin Med. 2019 Feb 22; 2019 Feb 22. PMID: 30813263.", + "Phenomic Impact of Genetically-Determined Euthyroid Function and Molecular Differences between Thyroid Disorders. Ravera S, Carrasco N, Gelernter J, Polimanti R. J Clin Med. 2018 Sep 21; 2018 Sep 21. PMID: 30248900.", + "Genetically determined schizophrenia is not associated with impaired glucose homeostasis. Polimanti R, Gelernter J, Stein DJ. Schizophr Res. 2018 May; 2017 Oct 29. PMID: 29092750.", + "Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits. Polimanti R, Kayser MH, Gelernter J. Genome Med. 2018 Mar 26; 2018 Mar 26. PMID: 29580271.", + "ADH1B: From alcoholism, natural selection, and cancer to the human phenome. Polimanti R, Gelernter J. Am J Med Genet B Neuropsychiatr Genet. 2018 Mar; 2017 Mar 27. PMID: 28349588.", + "Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers. Polimanti R, Kaufman J, Zhao H, Kranzler HR, Ursano RJ, Kessler RC, Stein MB, Gelernter J. Acta Psychiatr Scand. 2018 Feb; 2017 Dec 11. PMID: 29230810.", + "A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus. Polimanti R, Kaufman J, Zhao H, Kranzler HR, Ursano RJ, Kessler RC, Gelernter J, Stein MB. Mol Psychiatry. 2018 Jan; 2017 Mar 7. PMID: 28265120.", + "Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors. Polimanti R, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Am J Med Genet B Neuropsychiatr Genet. 2017 Dec; 2017 Oct 9. PMID: 28990359.", + "A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder. Polimanti R, Amstadter AB, Stein MB, Almli LM, Baker DG, Bierut LJ, Bradley B, Farrer LA, Johnson EO, King A, Kranzler HR, Maihofer AX, Rice JP, Roberts AL, Saccone NL, Zhao H, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC, Gelernter J. Genome Med. 2017 Nov 27; 2017 Nov 27. PMID: 29178946.", + "Non-coding variants contribute to the clinical heterogeneity of TTR amyloidosis. Iorio A, De Lillo A, De Angelis F, Di Girolamo M, Luigetti M, Sabatelli M, Pradotto L, Mauro A, Mazzeo A, Stancanelli C, Perfetto F, Frusconi S, My F, Manfellotto D, Fuciarelli M, Polimanti R. Eur J Hum Genet. 2017 Sep; 2017 Jun 21. PMID: 28635949.", + "S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours. Polimanti R, Meda SA, Pearlson GD, Zhao H, Sherva R, Farrer LA, Kranzler HR, Gelernter J. J Psychiatry Neurosci. 2017 Jun. PMID: 28418321.", + "Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers. Polimanti R, Jensen KP, Gelernter J. Sci Rep. 2017 Apr 21; 2017 Apr 21. PMID: 28432340.", + "Duplication of FOXP2 binding sites within CNTNAP2 gene in a girl with neurodevelopmental delay. Polimanti R, Squitti R, Pantaleo M, Giglio S, Zito G. Minerva Pediatr. 2017 Apr; 2016 May 24. PMID: 27215640.", + "Population diversity of the genetically determined TTR expression in human tissues and its implications in TTR amyloidosis. Iorio A, De Angelis F, Di Girolamo M, Luigetti M, Pradotto LG, Mazzeo A, Frusconi S, My F, Manfellotto D, Fuciarelli M, Polimanti R. BMC Genomics. 2017 Mar 23; 2017 Mar 23. PMID: 28335735.", + "Schizophrenia and substance use comorbidity: a genome-wide perspective. Polimanti R, Agrawal A, Gelernter J. Genome Med. 2017 Mar 21; 2017 Mar 21. PMID: 28327175.", + "Genome-wide association study of body mass index in subjects with alcohol dependence. Polimanti R, Zhang H, Smith AH, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Addict Biol. 2017 Mar; 2015 Oct 12. PMID: 26458734.", + "Cross-Phenotype Polygenic Risk Score Analysis of Persistent Post-Concussive Symptoms in U.S. Army Soldiers with Deployment-Acquired Traumatic Brain Injury. Polimanti R, Chen CY, Ursano RJ, Heeringa SG, Jain S, Kessler RC, Nock MK, Smoller JW, Sun X, Gelernter J, Stein MB. J Neurotrauma. 2017 Feb 15; 2016 Aug 25. PMID: 27439997.", + "Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder. Polimanti R, Gelernter J. PLoS Genet. 2017 Feb; 2017 Feb 10. PMID: 28187187.", + "The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene. Polimanti R, Wang Q, Meda SA, Patel KT, Pearlson GD, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Neuropsychopharmacology. 2017 Feb; 2016 Aug 17. PMID: 27531626.", + "Maps & Directions", + "Calendar", + "Contact us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Politi Lab", + "lab_url": "https://medicine.yale.edu/lab/politi/", + "research_bio": "INFORMATION FOR Copy Link In the laboratory we study lung cancer to answer the following questions: What are the alterations in cellular pathways that cause tumors to form? How can we interfere with these pathways to get tumors to regress? How do tumors become resistant to drugs? How can we detect tumors early when they are still curable? See thePoliti Lab Researchpage to read more in depth about the work we are doing in our Lab. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/politi/publications", + "publications": [ + "Yale School of Medicine /", + "Pathology /", + "Research", + "Contact Us", + "People", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "News", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Epigenetic priming promotes tyrosine kinase inhibitor resistance and oncogene amplification. Starble RM, Sun EG, Gbyli R, Radda J, Lu J, Jensen TB, Sun N, Khudaverdyan N, Zhao T, Hu B, Melnick MA, Zhao S, Roper N, Wang GG, Tackett AJ, Wang Y, Song J, Politi K, Wang S, Xiao AZ. Nat Struct Mol Biol. 2025 Oct 23; 2025 Oct 23. PMID: 41131337.", + "Advances in Lung Cancer Basic and Translational Research in 2025 - Overview and Perspectives Focusing on NSCLC. Mascaux C, Sen T, Sanchez-Cespedes M, Ortiz-Cuaran S, Bossé Y, Dammeijer F, Cavic M, Barr MP, Arulananda S, Armisen R, Berger AH, Bianchi F, Carbone DP, Cerciello F, Lockwood WW, Mitsudomi T, Ohara S, Politi K, Qin S, Roisman LC, Samstein R, Skoulidis F, Tan AC, Thomas A, Zhang J, Wynes MW, John T, Tsao MS. J Thorac Oncol. 2025 Oct; 2025 Jun 3. PMID: 40473107.", + "Lasering in on Uncommon EGFR Mutations. Kim SY, Politi K, Goldberg SB. J Thorac Oncol. 2025 Sep. PMID: 40914593.", + "EED Maintains the Small Cell Lung Cancer Neuroendocrine Phenotype and Drives Lung Cancer Histological Transformation. Li Y, Laimon YN, Cho H, Vivero M, De Oliveira GR, Delcea A, Savla V, Chen Y, Durmaz YT, Qiu X, Kukreja S, Li R, Zarif TE, Lu W, Orden MV, Berchuck JE, Bronson RT, Li S, Ji H, Politi K, Freedman ML, Long HW, Signoretti S, Oser MG. bioRxiv. 2025 Jul 10; 2025 Jul 10. PMID: 40672300.", + "Quantitative Protein Expression of Antibody-Drug Conjugate Targets in EGFR Mutated and Wild-type Non-Small Cell Lung Cancer. Trontzas IP, He M, Wurtz A, Robbins CJ, Robinson N, Bates K, Liu M, Aung TN, Scott L, Chan N, Burela S, Schillo J, Liebler DC, Hill S, Morrison RD, Vathiotis I, Syrigos KN, Goldberg SB, Politi K, Rimm DL. Clin Cancer Res. 2025 Jul 1. PMID: 40047548.", + "Intratumoral IL12 mRNA administration activates innate and adaptive pathways in checkpoint inhibitor-resistant tumors resulting in complete responses. Lakshmipathi J, Santha S, Li M, Qian Y, Roy SF, Luheshi N, Politi K, Bosenberg M, Eyles J, Muthusamy V. Cancer Immunol Immunother. 2025 Jun 25; 2025 Jun 25. PMID: 40560386.", + "Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation. Baro M, Lee H, Kelley V, Lou R, Phoomak C, Politi K, Zeiss CJ, Van Zandt M, Contessa JN. Cell Chem Biol. 2025 Jun 19; 2025 Jun 9. PMID: 40494352.", + "AURKA inhibition amplifies DNA replication stress to foster WEE1 kinase dependency and synergistic antitumor effects with WEE1 inhibition in cancers. Lee JW, Shi J, Barrantes J, Chaurasia P, Kim S, Cruz-Gomez S, Yang C, Gu J, Zhao H, Zhao D, Schiff B, Roche A, Perry EB, Townsend JP, Kupfer GM, Politi K, Golemis E, Burtness B. bioRxiv. 2025 May 29; 2025 May 29. PMID: 40501675.", + "The Evolution of Mouse Models of Cancer: Past, Present, and Future. Abate-Shen C, Politi K. Cold Spring Harb Perspect Med. 2025 May 5; 2025 May 5. PMID: 38772706.", + "Intratumoral IL12 mRNA administration activates innate and adaptive pathways in checkpoint inhibitor resistant tumors resulting in complete responses. Lakshmipathi J, Santha S, Li M, Qian Y, Roy SF, Luheshi N, Politi K, Bosenberg M, Eyles J, Muthusamy V. Res Sq. 2025 Apr 17; 2025 Apr 17. PMID: 40321762.", + "Epigenetic priming promotes acquisition of tyrosine kinase inhibitor resistance and oncogene amplification in human lung cancer. Starble RM, Sun EG, Gbyli R, Radda J, Lu J, Jensen TB, Sun N, Khudaverdyan N, Hu B, Melnick MA, Zhao S, Roper N, Wang GG, Song J, Politi K, Wang S, Xiao AZ. bioRxiv. 2025 Jan 27; 2025 Jan 27. PMID: 39974875.", + "Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer. Robles-Oteíza C, Hastings K, Choi J, Sirois I, Ravi A, Expósito F, de Miguel F, Knight JR, López-Giráldez F, Choi H, Socci ND, Merghoub T, Awad M, Getz G, Gainor J, Hellmann MD, Caron É, Kaech SM, Politi K. J Exp Med. 2025 Jan 6; 2024 Nov 25. PMID: 39585348.", + "OST Catalytic Subunit Redundancy Enables Therapeutic Targeting of N-Glycosylation. Baro M, Lee H, Kelley V, Lou R, Phoomak C, Politi K, Zeiss CJ, Van Zandt M, Contessa JN. bioRxiv. 2024 Dec 5; 2024 Dec 5. PMID: 39677793.", + "Chitinase 3-like-1 (CHI3L1) in the pathogenesis of epidermal growth factor receptor mutant non-small cell lung cancer. Kamle S, Ma B, Schor G, Bailey M, Pham B, Cho I, Khan H, Azzoli C, Hofstetter M, Sadanaga T, Herbst R, Politi K, Lee CG, Elias JA. Transl Oncol. 2024 Nov; 2024 Aug 22. PMID: 39178575.", + "Author Correction: Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer. Robichaux JP, Elamin YY, Tan Z, Carter BW, Zhang S, Liu S, Li S, Chen T, Poteete A, Estrada-Bernal A, Le AT, Truini A, Nilsson MB, Sun H, Roarty E, Goldberg SB, Brahmer JR, Altan M, Lu C, Papadimitrakopoulou V, Politi K, Doebele RC, Wong KK, Heymach JV. Nat Med. 2024 Sep. PMID: 39164519.", + "Overexpression of Malat1 drives metastasis through inflammatory reprogramming of the tumor microenvironment. Martinez-Terroba E, Plasek-Hegde LM, Chiotakakos I, Li V, de Miguel FJ, Robles-Oteiza C, Tyagi A, Politi K, Zamudio JR, Dimitrova N. Sci Immunol. 2024 Jun 14; 2024 Jun 14. PMID: 38875320.", + "ASCL1 Drives Tolerance to Osimertinib in EGFR Mutant Lung Cancer in Permissive Cellular Contexts. Hu B, Wiesehöfer M, de Miguel FJ, Liu Z, Chan LH, Choi J, Melnick MA, Arnal Estape A, Walther Z, Zhao D, Lopez-Giraldez F, Wurtz A, Cai G, Fan R, Gettinger S, Xiao A, Yan Q, Homer R, Nguyen DX, Politi K. Cancer Res. 2024 Apr 15. PMID: 38359163.", + "Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma. Kim IK, Diamond MS, Yuan S, Kemp SB, Kahn BM, Li Q, Lin JH, Li J, Norgard RJ, Thomas SK, Merolle M, Katsuda T, Tobias JW, Baslan T, Politi K, Vonderheide RH, Stanger BZ. Nat Commun. 2024 Feb 20; 2024 Feb 20. PMID: 38378697.", + "Co-Occurring Alterations in Multiple Tumor Suppressor Genes Are Associated With Worse Outcomes in Patients With EGFR-Mutant Lung Cancer. Stockhammer P, Grant M, Wurtz A, Foggetti G, Expósito F, Gu J, Zhao H, Choi J, Chung S, Li F, Walther Z, Dietz J, Duffield E, Gettinger S, Politi K, Goldberg SB. J Thorac Oncol. 2024 Feb; 2023 Oct 6. PMID: 37806385.", + "Patient-Derived Models of Cancer in the NCI PDMC Consortium: Selection, Pitfalls, and Practical Recommendations. Habowski AN, Budagavi DP, Scherer SD, Aurora AB, Caligiuri G, Flynn WF, Langer EM, Brody JR, Sears RC, Foggetti G, Arnal Estape A, Nguyen DX, Politi KA, Shen X, Hsu DS, Peehl DM, Kurhanewicz J, Sriram R, Suarez M, Xiao S, Du Y, Li XN, Navone NM, Labanca E, Willey CD. Cancers (Basel). 2024 Jan 29; 2024 Jan 29. PMID: 38339316.", + "EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and Growth. Kuhlmann-Hogan A, Cordes T, Xu Z, Kuna RS, Traina KA, Robles-Oteíza C, Ayeni D, Kwong EM, Levy S, Globig AM, Nobari MM, Cheng GZ, Leibel SL, Homer RJ, Shaw RJ, Metallo CM, Politi K, Kaech SM. Cancer Discov. 2024 Jan 25; 2024 Jan 25. PMID: 38270272.", + "EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth. Kuhlmann-Hogan A, Cordes T, Xu Z, Kuna RS, Traina KA, Robles-Oteiza C, Ayeni D, Kwong EM, Levy S, Globig AM, Nobari MM, Cheng GZ, Leibel SL, Homer RJ, Shaw RJ, Metallo CM, Politi K, Kaech SM. Cancer Discov. 2024 Jan 19; 2024 Jan 19. PMID: 38241033.", + "The New NCI Precision Medicine Trials. Harris LN, Blanke CD, Erba HP, Ford JM, Gray RJ, LeBlanc ML, Hu-Lieskovan S, Litzow MR, Luger SM, Meric-Bernstam F, O'Dwyer PJ, Othus MKD, Politi K, Shepherd LE, Allegra CJ, Chen HX, Ivy SP, Korde LA, Little RF, McShane LM, Moscow JA, Patton DR, Thurin M, Yee LM, Doroshow JH. Clin Cancer Res. 2023 Dec 1. PMID: 37531248.", + "Oncogenic context shapes the fitness landscape of tumor suppression. Blair LM, Juan JM, Sebastian L, Tran VB, Nie W, Wall GD, Gerceker M, Lai IK, Apilado EA, Grenot G, Amar D, Foggetti G, Do Carmo M, Ugur Z, Deng D, Chenchik A, Paz Zafra M, Dow LE, Politi K, MacQuitty JJ, Petrov DA, Winslow MM, Rosen MJ, Winters IP. Nat Commun. 2023 Oct 12; 2023 Oct 12. PMID: 37828026.", + "Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer. de Miguel FJ, Gentile C, Feng WW, Silva SJ, Sankar A, Exposito F, Cai WL, Melnick MA, Robles-Oteiza C, Hinkley MM, Tsai JA, Hartley AV, Wei J, Wurtz A, Li F, Toki MI, Rimm DL, Homer R, Wilen CB, Xiao AZ, Qi J, Yan Q, Nguyen DX, Jänne PA, Kadoch C, Politi KA. Cancer Cell. 2023 Aug 14; 2023 Aug 3. PMID: 37541244.", + "Effect of Dietary Supplementation with a Mixture of Natural Antioxidants on Milk Yield, Composition, Oxidation Stability and Udder Health in Dairy Ewes. Karageorgou A, Tsafou M, Goliomytis M, Hager-Theodorides A, Politi K, Simitzis P. Antioxidants (Basel). 2023 Aug 6; 2023 Aug 6. PMID: 37627566.", + "PTEN Loss Confers Resistance to Anti-PD-1 Therapy in Non-Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells. Exposito F, Redrado M, Houry M, Hastings K, Molero-Abraham M, Lozano T, Solorzano JL, Sanz-Ortega J, Adradas V, Amat R, Redin E, Leon S, Legarra N, Garcia J, Serrano D, Valencia K, Robles-Oteiza C, Foggetti G, Otegui N, Felip E, Lasarte JJ, Paz-Ares L, Zugazagoitia J, Politi K, Montuenga L, Calvo A. Cancer Res. 2023 Aug 1. PMID: 37311042.", + "Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment. Chiorazzi M, Martinek J, Krasnick B, Zheng Y, Robbins KJ, Qu R, Kaufmann G, Skidmore Z, Juric M, Henze LA, Brösecke F, Adonyi A, Zhao J, Shan L, Sefik E, Mudd J, Bi Y, Goedegebuure SP, Griffith M, Griffith O, Oyedeji A, Fertuzinhos S, Garcia-Milian R, Boffa D, Detterbeck F, Dhanasopon A, Blasberg J, Judson B, Gettinger S, Politi K, Kluger Y, Palucka K, Fields RC, Flavell RA. J Immunother Cancer. 2023 Jul. PMID: 37487666.", + "Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy. Kim IK, Diamond M, Yuan S, Kemp S, Li Q, Lin J, Li J, Norgard R, Thomas S, Merolle M, Katsuda T, Tobias J, Politi K, Vonderheide R, Stanger B. Res Sq. 2023 Jun 1; 2023 Jun 1. PMID: 37398248.", + "Efficacy of Osimertinib in Patients with Lung Cancer Positive for Uncommon EGFR Exon 19 Deletion Mutations. Grant MJ, Aredo JV, Starrett JH, Stockhammer P, van Alderwerelt van Rosenburgh IK, Wurtz A, Piper-Valillo AJ, Piotrowska Z, Falcon C, Yu HA, Aggarwal C, Scholes D, Patil T, Nguyen C, Phadke M, Li FY, Neal J, Lemmon MA, Walther Z, Politi K, Goldberg SB. Clin Cancer Res. 2023 Jun 1. PMID: 36913537.", + "An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1. Aftab F, Rodriguez-Fuguet A, Silva L, Kobayashi IS, Sun J, Politi K, Levantini E, Zhang W, Kobayashi SS, Zhang WC. Br J Cancer. 2023 May; 2023 Feb 21. PMID: 36810913.", + "EGFR (+) lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth. Kuhlmann-Hogan A, Cordes T, Xu Z, Traina KA, Robles-Oteíza C, Ayeni D, Kwong EM, Levy SR, Nobari M, Cheng GZ, Shaw R, Leibel SL, Metallo CM, Politi K, Kaech SM. bioRxiv. 2023 Apr 17; 2023 Apr 17. PMID: 37131637.", + "Challenges and opportunities for modeling aging and cancer. Anczuków O, Airhart S, Chuang JH, Coussens LM, Kuchel GA, Korstanje R, Li S, Lucido AL, McAllister SS, Politi K, Polyak K, Ratliff T, Ren G, Trowbridge JJ, Ucar D, Palucka K. Cancer Cell. 2023 Apr 10; 2023 Mar 30. PMID: 37001528.", + "Overexpressed Malat1 Drives Metastasis through Inflammatory Reprogramming of Lung Adenocarcinoma Microenvironment. Mart Nez-Terroba E, de Miguel FJ, Li V, Robles-Oteiza C, Politi K, Zamudio JR, Dimitrova N. bioRxiv. 2023 Mar 23; 2023 Mar 23. PMID: 36993368.", + "Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer. Adua SJ, Arnal-Estapé A, Zhao M, Qi B, Liu ZZ, Kravitz C, Hulme H, Strittmatter N, López-Giráldez F, Chande S, Albert AE, Melnick MA, Hu B, Politi K, Chiang V, Colclough N, Goodwin RJA, Cross D, Smith P, Nguyen DX. Nat Commun. 2022 Dec 12; 2022 Dec 12. PMID: 36509758.", + "A path to translation: How 3D patient tumor avatars enable next generation precision oncology. Bose S, Barroso M, Chheda MG, Clevers H, Elez E, Kaochar S, Kopetz SE, Li XN, Meric-Bernstam F, Meyer CA, Mou H, Naegle KM, Pera MF, Perova Z, Politi KA, Raphael BJ, Robson P, Sears RC, Tabernero J, Tuveson DA, Welm AL, Welm BE, Willey CD, Salnikow K, Chuang JH, Shen X. Cancer Cell. 2022 Dec 12; 2022 Oct 20. PMID: 36270276.", + "YES1 Is a Druggable Oncogenic Target in SCLC. Redin E, Garrido-Martin EM, Valencia K, Redrado M, Solorzano JL, Carias R, Echepare M, Exposito F, Serrano D, Ferrer I, Nunez-Buiza A, Garmendia I, García-Pedrero JM, Gurpide A, Paz-Ares L, Politi K, Montuenga LM, Calvo A. J Thorac Oncol. 2022 Dec; 2022 Aug 18. PMID: 35988891.", + "Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations. van Alderwerelt van Rosenburgh IK, Lu DM, Grant MJ, Stayrook SE, Phadke M, Walther Z, Goldberg SB, Politi K, Lemmon MA, Ashtekar KD, Tsutsui Y. Nat Commun. 2022 Nov 10; 2022 Nov 10. PMID: 36357385.", + "Circulating Tumor DNA Kinetics Predict Progression-Free and Overall Survival in EGFR TKI-Treated Patients with EGFR-Mutant NSCLC (SWOG S1403). Mack PC, Miao J, Redman MW, Moon J, Goldberg SB, Herbst RS, Melnick MA, Walther Z, Hirsch FR, Politi K, Kelly K, Gandara DR. Clin Cancer Res. 2022 Sep 1. PMID: 35713632.", + "Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment. Papadas A, Deb G, Cicala A, Officer A, Hope C, Pagenkopf A, Flietner E, Morrow ZT, Emmerich P, Wiesner J, Arauz G, Bansal V, Esbona K, Capitini CM, Matkowskyj KA, Deming DA, Politi K, Abrams SI, Harismendy O, Asimakopoulos F. Cell Rep. 2022 Aug 16. PMID: 35977482.", + "Author Correction: Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer. Bartolacci C, Andreani C, Vale G, Berto S, Melegari M, Crouch AC, Baluya DL, Kemble G, Hodges K, Starrett J, Politi K, Starnes SL, Lorenzini D, Raso MG, Solis Soto LM, Behrens C, Kadara H, Gao B, Wistuba II, Minna JD, McDonald JG, Scaglioni PP. Nat Commun. 2022 Aug 8; 2022 Aug 8. PMID: 35941179.", + "Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer. Bartolacci C, Andreani C, Vale G, Berto S, Melegari M, Crouch AC, Baluya DL, Kemble G, Hodges K, Starrett J, Politi K, Starnes SL, Lorenzini D, Raso MG, Solis Soto LM, Behrens C, Kadara H, Gao B, Wistuba II, Minna JD, McDonald JG, Scaglioni PP. Nat Commun. 2022 Jul 26; 2022 Jul 26. PMID: 35882862.", + "A group approach to growing as a principal investigator. Greco V, Politi K, Eisenbarth S, Colón-Ramos D, Giraldez AJ, Bewersdorf J, Berg DN. Curr Biol. 2022 Jun 6. PMID: 35671717.", + "Anti-PD-L1 and anti-CD73 combination therapy promotes T cell response to EGFR-mutated NSCLC. Tu E, McGlinchey K, Wang J, Martin P, Ching SL, Floc'h N, Kurasawa J, Starrett JH, Lazdun Y, Wetzel L, Nuttall B, Ng FS, Coffman KT, Smith PD, Politi K, Cooper ZA, Streicher K. JCI Insight. 2022 Feb 8; 2022 Feb 8. PMID: 35132961.", + "Multimodal analysis suggests differential immuno-metabolic crosstalk in lung squamous cell carcinoma and adenocarcinoma. Leitner BP, Givechian KB, Ospanova S, Beisenbayeva A, Politi K, Perry RJ. NPJ Precis Oncol. 2022 Jan 27; 2022 Jan 27. PMID: 35087143.", + "Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment. Foggetti G, Li C, Cai H, Petrov DA, Winslow MM, Politi K. Mol Cell Oncol. 2022; 2022 Jan 14. PMID: 35252550.", + "Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein. Tripathi BK, Anderman MF, Bhargava D, Boccuzzi L, Qian X, Wang D, Durkin ME, Papageorge AG, de Miguel FJ, Politi K, Walters KJ, Doroshow JH, Lowy DR. Nat Commun. 2021 Dec 3; 2021 Dec 3. PMID: 34862367.", + "Preclinical Models for the Study of Lung Cancer Pathogenesis and Therapy Development. Arnal-Estapé A, Foggetti G, Starrett JH, Nguyen DX, Politi K. Cold Spring Harb Perspect Med. 2021 Dec 1; 2021 Dec 1. PMID: 34518338.", + "Elevated murine HB-EGF confers sensitivity to diphtheria toxin in EGFR-mutant lung adenocarcinoma. Robles-Oteiza C, Ayeni D, Levy S, Homer RJ, Kaech SM, Politi K. Dis Model Mech. 2021 Nov 1; 2021 Nov 15. PMID: 34494649.", + "Cycling cancer persister cells arise from lineages with distinct programs. Oren Y, Tsabar M, Cuoco MS, Amir-Zilberstein L, Cabanos HF, Hütter JC, Hu B, Thakore PI, Tabaka M, Fulco CP, Colgan W, Cuevas BM, Hurvitz SA, Slamon DJ, Deik A, Pierce KA, Clish C, Hata AN, Zaganjor E, Lahav G, Politi K, Brugge JS, Regev A. Nature. 2021 Aug; 2021 Aug 11. PMID: 34381210.", + "Genetic Determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo. Foggetti G, Li C, Cai H, Hellyer JA, Lin WY, Ayeni D, Hastings K, Choi J, Wurtz A, Andrejka L, Maghini DG, Rashleigh N, Levy S, Homer R, Gettinger SN, Diehn M, Wakelee HA, Petrov DA, Winslow MM, Politi K. Cancer Discov. 2021 Jul; 2021 Mar 11. PMID: 33707235.", + "Genetic Diversity and Epidemiological Significance of Wild Boar HEV-3 Strains Circulating in Poland. Kozyra I, Bigoraj E, Jabłoński A, Politi K, Rzeżutka A. Viruses. 2021 Jun 19; 2021 Jun 19. PMID: 34205456.", + "Hesperidin and Naringin Improve Broiler Meat Fatty Acid Profile and Modulate the Expression of Genes Involved in Fatty Acid β-oxidation and Antioxidant Defense in a Dose Dependent Manner. Hager-Theodorides AL, Massouras T, Simitzis PE, Moschou K, Zoidis E, Sfakianaki E, Politi K, Charismiadou M, Goliomytis M, Deligeorgis S. Foods. 2021 Mar 31; 2021 Mar 31. PMID: 33807218.", + "Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection. Wei J, Alfajaro MM, DeWeirdt PC, Hanna RE, Lu-Culligan WJ, Cai WL, Strine MS, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Ravindra NG, Gasque V, de Miguel FJ, Patil A, Chen H, Oguntuyo KY, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach BD, Politi K, van Dijk D, Kadoch C, Simon MD, Yan Q, Doench JG, Wilen CB. Cell. 2021 Jan 7; 2020 Oct 20. PMID: 33147444.", + "Randomized Trial of Afatinib Plus Cetuximab Versus Afatinib Alone for First-Line Treatment of EGFR-Mutant Non-Small-Cell Lung Cancer: Final Results From SWOG S1403. Goldberg SB, Redman MW, Lilenbaum R, Politi K, Stinchcombe TE, Horn L, Chen EH, Mashru SH, Gettinger SN, Melnick MA, Herbst RS, Baumgart MA, Miao J, Moon J, Kelly K, Gandara DR. J Clin Oncol. 2020 Dec 1; 2020 Oct 6. PMID: 33021871.", + "Deconstructing tumor heterogeneity: the stromal perspective. Vickman RE, Faget DV, Beachy P, Beebe D, Bhowmick NA, Cukierman E, Deng WM, Granneman JG, Hildesheim J, Kalluri R, Lau KS, Lengyel E, Lundeberg J, Moscat J, Nelson PS, Pietras K, Politi K, Puré E, Scherz-Shouval R, Sherman MH, Tuveson D, Weeraratna AT, White RM, Wong MH, Woodhouse EC, Zheng Y, Hayward SW, Stewart SA. Oncotarget. 2020 Oct 6; 2020 Oct 6. PMID: 33088423.", + "Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection. Wei J, Alfajaro MM, Hanna RE, DeWeirdt PC, Strine MS, Lu-Culligan WJ, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Gasque V, de Miguel F, Chen H, Oguntuyo K, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach B, Politi K, van Dijk D, Simon MD, Yan Q, Doench JG, Wilen CB. bioRxiv. 2020 Jun 17; 2020 Jun 17. PMID: 32869025.", + "Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations. Starrett JH, Guernet AA, Cuomo ME, Poels KE, van Alderwerelt van Rosenburgh IK, Nagelberg A, Farnsworth D, Price KS, Khan H, Ashtekar KD, Gaefele M, Ayeni D, Stewart TF, Kuhlmann A, Kaech SM, Unni AM, Homer R, Lockwood WW, Michor F, Goldberg SB, Lemmon MA, Smith PD, Cross DAE, Politi K. Cancer Res. 2020 May 15; 2020 Mar 19. PMID: 32193290.", + "Leveraging Patient-Derived Models for Immunotherapy Research. Politi K. Am Soc Clin Oncol Educ Book. 2020 May. PMID: 32511030.", + "Assessment of IFNγ responsiveness in patient-derived xenografts. Cardenas JJ, Robles-Oteiza C, Politi K. Methods Enzymol. 2020; 2019 Dec 9. PMID: 31948560.", + "The EGFR Exon 19 Mutant L747-A750>P Exhibits Distinct Sensitivity to Tyrosine Kinase Inhibitors in Lung Adenocarcinoma. Truini A, Starrett JH, Stewart T, Ashtekar K, Walther Z, Wurtz A, Lu D, Park JH, DeVeaux M, Song X, Gettinger S, Zelterman D, Lemmon MA, Goldberg SB, Politi K. Clin Cancer Res. 2019 Nov 1; 2019 Jun 10. PMID: 31182434.", + "The great debate at \"Immunotherapy Bridge 2018\", Naples, November 29th, 2018. Ascierto PA, Butterfield LH, Demaria S, Ferris RL, Freeman GJ, Lo RS, Mantovani A, Nathan P, Hamid O, Politi K, Puzanov I. J Immunother Cancer. 2019 Aug 15; 2019 Aug 15. PMID: 31416487.", + "Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non-Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis. Datar I, Sanmamed MF, Wang J, Henick BS, Choi J, Badri T, Dong W, Mani N, Toki M, Mejías LD, Lozano MD, Perez-Gracia JL, Velcheti V, Hellmann MD, Gainor JF, McEachern K, Jenkins D, Syrigos K, Politi K, Gettinger S, Rimm DL, Herbst RS, Melero I, Chen L, Schalper KA. Clin Cancer Res. 2019 Aug 1; 2019 May 3. PMID: 31053602.", + "Immunotherapy in Non-Small Cell Lung Cancer: Facts and Hopes. Doroshow DB, Sanmamed MF, Hastings K, Politi K, Rimm DL, Chen L, Melero I, Schalper KA, Herbst RS. Clin Cancer Res. 2019 Aug 1; 2019 Mar 1. PMID: 30824587.", + "Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors. Ayeni D, Miller B, Kuhlmann A, Ho PC, Robles-Oteiza C, Gaefele M, Levy S, de Miguel FJ, Perry C, Guan T, Krystal G, Lockwood W, Zelterman D, Homer R, Liu Z, Kaech S, Politi K. J Immunother Cancer. 2019 Jul 10; 2019 Jul 10. PMID: 31291990.", + "Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop. Bedognetti D, Ceccarelli M, Galluzzi L, Lu R, Palucka K, Samayoa J, Spranger S, Warren S, Wong KK, Ziv E, Chowell D, Coussens LM, De Carvalho DD, DeNardo DG, Galon J, Kaufman HL, Kirchhoff T, Lotze MT, Luke JJ, Minn AJ, Politi K, Shultz LD, Simon R, Thórsson V, Weidhaas JB, Ascierto ML, Ascierto PA, Barnes JM, Barsan V, Bommareddy PK, Bot A, Church SE, Ciliberto G, De Maria A, Draganov D, Ho WS, McGee HM, Monette A, Murphy JF, Nisticò P, Park W, Patel M, Quigley M, Radvanyi L, Raftopoulos H, Rudqvist NP, Snyder A, Sweis RF, Valpione S, Zappasodi R, Butterfield LH, Disis ML, Fox BA, Cesano A, Marincola FM. J Immunother Cancer. 2019 Jul 4; 2019 Jul 4. PMID: 31272507.", + "Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop. Bedognetti D, Ceccarelli M, Galluzzi L, Lu R, Palucka K, Samayoa J, Spranger S, Warren S, Wong KK, Ziv E, Chowell D, Coussens LM, De Carvalho DD, DeNardo DG, Galon J, Kaufman HL, Kirchhoff T, Lotze MT, Luke JJ, Minn AJ, Politi K, Shultz LD, Simon R, Thórsson V, Weidhaas JB, Ascierto ML, Ascierto PA, Barnes JM, Barsan V, Bommareddy PK, Bot A, Church SE, Ciliberto G, De Maria A, Draganov D, Ho WS, McGee HM, Monette A, Murphy JF, Nisticò P, Park W, Patel M, Quigley M, Radvanyi L, Raftopoulos H, Rudqvist NP, Snyder A, Sweis RF, Valpione S, Zappasodi R, Butterfield LH, Disis ML, Fox BA, Cesano A, Marincola FM. J Immunother Cancer. 2019 May 22; 2019 May 22. PMID: 31113486.", + "Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis. Wingrove E, Liu ZZ, Patel KD, Arnal-Estapé A, Cai WL, Melnick MA, Politi K, Monteiro C, Zhu L, Valiente M, Kluger HM, Chiang VL, Nguyen DX. Cell Rep. 2019 Apr 23. PMID: 31018140.", + "miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma. Zhang WC, Wells JM, Chow KH, Huang H, Yuan M, Saxena T, Melnick MA, Politi K, Asara JM, Costa DB, Bult CJ, Slack FJ. Nat Metab. 2019 Apr; 2019 Apr 8. PMID: 31535082.", + "YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics. Fan PD, Narzisi G, Jayaprakash AD, Venturini E, Robine N, Smibert P, Germer S, Yu HA, Jordan EJ, Paik PK, Janjigian YY, Chaft JE, Wang L, Jungbluth AA, Middha S, Spraggon L, Qiao H, Lovly CM, Kris MG, Riely GJ, Politi K, Varmus H, Ladanyi M. Proc Natl Acad Sci U S A. 2018 Jun 26; 2018 Jun 6. PMID: 29875142.", + "ERBB Signaling Interrupted: Targeting Ligand-Induced Pathway Activation. Wilson FH, Politi K. Cancer Discov. 2018 Jun. PMID: 29858224.", + "Clinical Features and Management of Acquired Resistance to PD-1 Axis Inhibitors in 26 Patients With Advanced Non-Small Cell Lung Cancer. Gettinger SN, Wurtz A, Goldberg SB, Rimm D, Schalper K, Kaech S, Kavathas P, Chiang A, Lilenbaum R, Zelterman D, Politi K, Herbst RS. J Thorac Oncol. 2018 Jun; 2018 Mar 22. PMID: 29578107.", + "Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer. Robichaux JP, Elamin YY, Tan Z, Carter BW, Zhang S, Liu S, Li S, Chen T, Poteete A, Estrada-Bernal A, Le AT, Truini A, Nilsson MB, Sun H, Roarty E, Goldberg SB, Brahmer JR, Altan M, Lu C, Papadimitrakopoulou V, Politi K, Doebele RC, Wong KK, Heymach JV. Nat Med. 2018 May; 2018 Apr 23. PMID: 29686424.", + "Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA. Goldberg SB, Narayan A, Kole AJ, Decker RH, Teysir J, Carriero NJ, Lee A, Nemati R, Nath SK, Mane SM, Deng Y, Sukumar N, Zelterman D, Boffa DJ, Politi K, Gettinger SN, Wilson LD, Herbst RS, Patel AA. Clin Cancer Res. 2018 Apr 15; 2018 Jan 12. PMID: 29330207.", + "The Impact of Smoking and TP53 Mutations in Lung Adenocarcinoma Patients with Targetable Mutations-The Lung Cancer Mutation Consortium (LCMC2). Aisner DL, Sholl LM, Berry LD, Rossi MR, Chen H, Fujimoto J, Moreira AL, Ramalingam SS, Villaruz LC, Otterson GA, Haura E, Politi K, Glisson B, Cetnar J, Garon EB, Schiller J, Waqar SN, Sequist LV, Brahmer J, Shyr Y, Kugler K, Wistuba II, Johnson BE, Minna JD, Kris MG, Bunn PA, Kwiatkowski DJ. Clin Cancer Res. 2018 Mar 1; 2017 Dec 7. PMID: 29217530.", + "Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer. Gettinger S, Choi J, Hastings K, Truini A, Datar I, Sowell R, Wurtz A, Dong W, Cai G, Melnick MA, Du VY, Schlessinger J, Goldberg SB, Chiang A, Sanmamed MF, Melero I, Agorreta J, Montuenga LM, Lifton R, Ferrone S, Kavathas P, Rimm DL, Kaech SM, Schalper K, Herbst RS, Politi K. Cancer Discov. 2017 Dec; 2017 Oct 12. PMID: 29025772.", + "Genome-Wide RNA Interference: Functional Genomics in the Postgenomics Era. Politi K, Wajapeyee N. Cold Spring Harb Protoc. 2017 Sep 1; 2017 Sep 1. PMID: 28864574.", + "Therapy-induced E-cadherin downregulation alters expression of programmed death ligand-1 in lung cancer cells. Suda K, Rozeboom L, Rivard CJ, Yu H, Ellison K, Melnick MAC, Hinz TK, Chan D, Heasley LE, Politi K, Mitsudomi T, Hirsch FR. Lung Cancer. 2017 Jul; 2017 Apr 19. PMID: 28577937.", + "Increased EGFR Phosphorylation Correlates with Higher Programmed Death Ligand-1 Expression: Analysis of TKI-Resistant Lung Cancer Cell Lines. Suda K, Rozeboom L, Furugaki K, Yu H, Melnick MAC, Ellison K, Rivard CJ, Politi K, Mitsudomi T, Hirsch FR. Biomed Res Int. 2017; 2017 Oct 8. PMID: 29119113.", + "Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma. McFadden DG, Politi K, Bhutkar A, Chen FK, Song X, Pirun M, Santiago PM, Kim-Kiselak C, Platt JT, Lee E, Hodges E, Rosebrock AP, Bronson RT, Socci ND, Hannon GJ, Jacks T, Varmus H. Proc Natl Acad Sci U S A. 2016 Oct 18; 2016 Oct 4. PMID: 27702896.", + "PD-1 Axis Inhibitors in EGFR- and ALK-Driven Lung Cancer: Lost Cause? Gettinger S, Politi K. Clin Cancer Res. 2016 Sep 15; 2016 Jul 28. PMID: 27470969.", + "Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells. Forloni M, Gupta R, Nagarajan A, Sun LS, Dong Y, Pirazzoli V, Toki M, Wurtz A, Melnick MA, Kobayashi S, Homer RJ, Rimm DL, Gettinger SJ, Politi K, Dogra SK, Wajapeyee N. Cell Rep. 2016 Jul 12; 2016 Jun 23. PMID: 27346347.", + "Afatinib plus Cetuximab Delays Resistance Compared to Single-Agent Erlotinib or Afatinib in Mouse Models of TKI-Naïve EGFR L858R-Induced Lung Adenocarcinoma. Pirazzoli V, Ayeni D, Meador CB, Sanganahalli BG, Hyder F, de Stanchina E, Goldberg SB, Pao W, Politi K. Clin Cancer Res. 2016 Jan 15; 2015 Sep 4. PMID: 26341921.", + "Emerging Agents and New Mutations in EGFR-Mutant Lung Cancer. Ayeni D, Politi K, Goldberg SB. Clin Cancer Res. 2015 Sep 1; 2015 Jul 13. PMID: 26169963.", + "The Next Wave of EGFR Tyrosine Kinase Inhibitors Enter the Clinic. Politi K, Ayeni D, Lynch T. Cancer Cell. 2015 Jun 8. PMID: 26058074.", + "Lung cancer in the era of precision medicine. Politi K, Herbst RS. Clin Cancer Res. 2015 May 15. PMID: 25979927.", + "EGFR Mutations in Non-Small-Cell Lung Cancer: Find, Divide, and Conquer. Morgensztern D, Politi K, Herbst RS. JAMA Oncol. 2015 May. PMID: 26181013.", + "Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma. Maity TK, Venugopalan A, Linnoila I, Cultraro CM, Giannakou A, Nemati R, Zhang X, Webster JD, Ritt D, Ghosal S, Hoschuetzky H, Simpson RM, Biswas R, Politi K, Morrison DK, Varmus HE, Guha U. Cancer Discov. 2015 May; 2015 Mar 3. PMID: 25735773.", + "Isolation of epithelial, endothelial, and immune cells from lungs of transgenic mice with oncogene-induced lung adenocarcinomas. Bantikassegn A, Song X, Politi K. Am J Respir Cell Mol Biol. 2015 Apr. PMID: 25347711.", + "ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas. Song X, Fan PD, Bantikassegn A, Guha U, Threadgill DW, Varmus H, Politi K. Cancer Res. 2015 Mar 15; 2015 Jan 16. PMID: 25596284.", + "Optimizing the sequence of anti-EGFR-targeted therapy in EGFR-mutant lung cancer. Meador CB, Jin H, de Stanchina E, Nebhan CA, Pirazzoli V, Wang L, Lu P, Vuong H, Hutchinson KE, Jia P, Chen X, Eisenberg R, Ladanyi M, Politi K, Zhao Z, Lovly CM, Cross DA, Pao W. Mol Cancer Ther. 2015 Feb; 2014 Dec 4. PMID: 25477325.", + "Perfect ALKemy: optimizing the use of ALK-directed therapies in lung cancer. Politi K, Gettinger S. Clin Cancer Res. 2014 Nov 15; 2014 Sep 16. PMID: 25228532.", + "Acquired resistance of EGFR-mutant lung adenocarcinomas to afatinib plus cetuximab is associated with activation of mTORC1. Pirazzoli V, Nebhan C, Song X, Wurtz A, Walther Z, Cai G, Zhao Z, Jia P, de Stanchina E, Shapiro EM, Gale M, Yin R, Horn L, Carbone DP, Stephens PJ, Miller V, Gettinger S, Pao W, Politi K. Cell Rep. 2014 May 22; 2014 May 9. PMID: 24813888.", + "Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer. de Bruin EC, Cowell C, Warne PH, Jiang M, Saunders RE, Melnick MA, Gettinger S, Walther Z, Wurtz A, Heynen GJ, Heideman DA, Gómez-Román J, García-Castaño A, Gong Y, Ladanyi M, Varmus H, Bernards R, Smit EF, Politi K, Downward J. Cancer Discov. 2014 May; 2014 Feb 17. PMID: 24535670.", + "MYCxing it up with FGFR1 in squamous cell lung cancer. Lockwood W, Politi K. Cancer Discov. 2014 Feb. PMID: 24501305.", + "Generation of drug-resistant tumors using intermittent dosing of tyrosine kinase inhibitors in mouse. Pirazzoli V, Politi K. Cold Spring Harb Protoc. 2014 Feb 1; 2014 Feb 1. PMID: 24492774.", + "Translational therapeutics in genetically engineered mouse models of cancer. Olive KP, Politi K. Cold Spring Harb Protoc. 2014 Feb 1; 2014 Feb 1. PMID: 24492770.", + "De novo selection of oncogenes. Chacón KM, Petti LM, Scheideman EH, Pirazzoli V, Politi K, DiMaio D. Proc Natl Acad Sci U S A. 2014 Jan 7; 2013 Dec 16. PMID: 24344264.", + "DOK2 inhibits EGFR-mutated lung adenocarcinoma. Berger AH, Chen M, Morotti A, Janas JA, Niki M, Bronson RT, Taylor BS, Ladanyi M, Van Aelst L, Politi K, Varmus HE, Pandolfi PP. PLoS One. 2013; 2013 Nov 8. PMID: 24255704.", + "Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance. Jia P, Jin H, Meador CB, Xia J, Ohashi K, Liu L, Pirazzoli V, Dahlman KB, Politi K, Michor F, Zhao Z, Pao W. Genome Res. 2013 Sep; 2013 Jun 3. PMID: 23733853.", + "Sterling Hall of Medicine 333 Cedar Street New Haven, CT 06520-8023 Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Pollitt Lab", + "lab_url": "https://medicine.yale.edu/lab/pollitt/", + "research_bio": "INFORMATION FOR Exposure to air pollution is unavoidable and ranks in the top ten global health risks attributable to non-communicable diseases. Research in the Pollitt lab is focus on understanding the relationship between exposure to complex mixtures of air pollutants and disease. The research team is developing novel analytical approaches to characterise personal environmental exposures to understand how these pollutant exposures can adversely affect health. We use mass spectrometry techniques to analyse environmental and biological samples for pollutants and metabolites related to air pollutant exposure. Copy Link Principal Investigator Associate Professor of Epidemiology (Environmental Health); Affiliated Faculty, Yale Institute for Global Health", + "publications_page": "https://medicine.yale.edu/lab/pollitt/publications/", + "publications": [ + "Yale School of Public Health /", + "Environmental Health Sciences /", + "Projects Healthy Air Network Monitoring Chemicals in Outdoor Air PFAS Polysorbates COVID-19", + "Healthy Air Network", + "Monitoring Chemicals in Outdoor Air", + "PFAS", + "Polysorbates", + "COVID-19", + "Contact Us", + "People", + "News", + "Publications", + "Prospective Students", + "Alumni", + "Donors", + "Employers", + "Academic Calendar", + "myYSPH Members", + "Support YSPH", + "Projects", + "People", + "News", + "Publications", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Shedding Light on PFAS Dark Matter Using a Novel GC-HRMS Approach. Koelmel JP, Lin EZ, Chang P, Johnson E, Stelben P, Liu S, Nishida K, Tsugawa H, Lin A, Newton S, Casey JS, Nikiforov V, Roberts D, Aksenov A, Okeme J, Metayer C, Vieira VM, Manz KE, Braun JM, Pennell KD, Robey NM, Bangma J, Strynar M, Townsend TG, Bowden JA, Godri Pollitt KJ. Environ Sci Technol. 2025 Nov 17; 2025 Nov 17. PMID: 41249893.", + "Emerging PFAS in Songbird Eggs from a Belgian Hotspot Site. Cappelli F, Groffen T, Buytaert J, Prinsen E, Eens M, Bervoets L, Zhao L, Yin S, Koelmel JP, Kummer M, Godri Pollitt K, Covaci A. Environ Res. 2025 Oct 17; 2025 Oct 17. PMID: 41110788.", + "Exposure to per- and polyfluoroalkyl substances in residential settled dust and risk of childhood acute lymphoblastic leukemia. Metayer C, Morimoto LM, Vieira VM, Godri Pollitt KJ, Bartell SM, Wong L, Young TM. Int J Cancer. 2025 Jul 1; 2025 Feb 14. PMID: 39950710.", + "FluoroMatch IM: An Interactive Software for PFAS Analysis by Ion Mobility Spectrometry. Smolinski R, Koelmel JP, Stelben P, Weil D, Godri D, Schiessel D, Kummer M, Stow SM, Mohsin S, Royer L, McKenzie-Coe A, Lubinsky T, DeBord D, Chevallier O, Rennie EE, Godri Pollitt KJ, McDonough C. Environ Sci Technol. 2025 Apr 8; 2025 Mar 25. PMID: 40133053.", + "Filling the Gaps in PFAS Detection: Integrating GC-MS Non-Targeted Analysis for Comprehensive Environmental Monitoring and Exposure Assessment. Newton SR, Bowden JA, Charest N, Jackson SR, Koelmel JP, Liberatore HK, Lin AM, Lowe CN, Nieto S, Godri Pollitt KJ, Robuck AR, Rostkowski P, Townsend TG, Wallace MAG, Williams AJ. Environ Sci Technol Lett. 2025 Jan 23. PMID: 40206203.", + "Expanding PFAS Identification with Transformation Product Libraries: Nontargeted Analysis Reveals Biotransformation Products in Mice. Liu S, Dukes DA, Koelmel JP, Stelben P, Finch J, Okeme J, Lowe C, Williams A, Godri D, Rennie EE, Parry E, McDonough CA, Godri Pollitt KJ. Environ Sci Technol. 2025 Jan 14; 2024 Dec 20. PMID: 39704186.", + "A deployable film method to enable replicable sampling of low-abundance environmental microbiomes. Mankiewicz Ledins P, Lin EZ, Bhattacharya C, Pollitt KJG, Dyson AH, Hénaff EM. Sci Rep. 2024 Oct 11; 2024 Oct 11. PMID: 39394219.", + "Personal exposure to airborne organic pollutants and lung function changes among healthy older adults. Guo X, Ren H, Sun P, Ding E, Fang J, Fang K, Ma X, Li C, Li C, Xu Y, Cao K, Lin EZ, Guo P, Pollitt KJG, Tong S, Tang S, Shi X. Environ Res. 2024 Oct 1; 2024 Jun 13. PMID: 38876423.", + "Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study. Ding E, Deng F, Fang J, Liu J, Yan W, Yao Q, Miao K, Wang Y, Sun P, Li C, Liu Y, Dong H, Dong L, Zhang X, Lu Y, Lin X, Ding C, Li T, Shi Y, Cai Y, Liu X, Godri Pollitt KJ, Ji JS, Tong S, Tang S, Shi X. Environ Health Perspect. 2024 Sep; 2024 Sep 6. PMID: 39240788.", + "High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage. Lai Y, Koelmel JP, Walker DI, Price EJ, Papazian S, Manz KE, Castilla-Fernández D, Bowden JA, Nikiforov V, David A, Bessonneau V, Amer B, Seethapathy S, Hu X, Lin EZ, Jbebli A, McNeil BR, Barupal D, Cerasa M, Xie H, Kalia V, Nandakumar R, Singh R, Tian Z, Gao P, Zhao Y, Froment J, Rostkowski P, Dubey S, Coufalíková K, Seličová H, Hecht H, Liu S, Udhani HH, Restituito S, Tchou-Wong KM, Lu K, Martin JW, Warth B, Godri Pollitt KJ, Klánová J, Fiehn O, Metz TO, Pennell KD, Jones DP, Miller GW. Environ Sci Technol. 2024 Jul 23; 2024 Jul 10. PMID: 38984754.", + "Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60-69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study. Sun P, Guo X, Ding E, Li C, Ren H, Xu Y, Qian J, Deng F, Shi W, Dong H, Lin EZ, Guo P, Fang J, Zhang Q, Zhao W, Tong S, Lu X, Pollitt KJG, Shi X, Tang S. Environ Health Perspect. 2024 Jul; 2024 Jul 19. PMID: 39028628.", + "PolyMatch: Novel Libraries, Algorithms, and Visualizations for Discovering Polymers and Chemical Series. Koelmel JP, Stelben P, Oranzi N, Kummer M, Godri D, Qi J, Rennie EE, Lin E, Weil D, Godri Pollitt KJ. J Am Soc Mass Spectrom. 2024 Mar 6; 2024 Feb 1. PMID: 38301121.", + "Assessment of wood smoke induced pulmonary toxicity in normal- and chronic bronchitis-like bronchial and alveolar lung mucosa models at air-liquid interface. Upadhyay S, Rahman M, Rinaldi S, Koelmel J, Lin EZ, Mahesh PA, Beckers J, Johanson G, Pollitt KJG, Palmberg L, Irmler M, Ganguly K. Respir Res. 2024 Jan 20; 2024 Jan 20. PMID: 38245732.", + "Household air pollution and risk of pulmonary tuberculosis in HIV-Infected adults. Katoto PDMC, Bihehe D, Brand A, Mushi R, Kusinza A, Alwood BW, van Zyl-Smit RN, Tamuzi JL, Sam-Agudu NA, Yotebieng M, Metcalfe J, Theron G, Godri Pollitt KJ, Lesosky M, Vanoirbeek J, Mortimer K, Nawrot T, Nemery B, Nachega JB. Environ Health. 2024 Jan 17; 2024 Jan 17. PMID: 38233832.", + "Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids. Zheng J, Sun B, Berardi D, Lu L, Yan H, Zheng S, Aladelokun O, Xie Y, Cai Y, Godri Pollitt KJ, Khan SA, Johnson CH. Environ Sci Technol. 2023 Dec 19; 2023 Dec 8. PMID: 38064429.", + "Per- and polyfluoroalkyl substances and sleep health in U.S. adults, NHANES 2005-2014. Guo P, Jin Z, Bellia G, Luo J, Inoue K, Pollitt KJG, Deziel NC, Liew Z. Environ Res. 2023 Nov 15; 2023 Sep 6. PMID: 37683785.", + "Expanding Per- and Polyfluoroalkyl Substances Coverage in Nontargeted Analysis Using Data-Independent Analysis and IonDecon. Koelmel JP, Kummer M, Chevallier O, Hindle R, Hunt K, Camacho CG, Abril N, Gill EL, Beecher CWW, Garrett TJ, Yost RA, Townsend TG, Klein C, Rennie EE, Bowden JA, Godri Pollitt KJ. J Am Soc Mass Spectrom. 2023 Nov 1; 2023 Sep 26. PMID: 37751518.", + "Household Air Pollution and Risk of Pulmonary Tuberculosis in HIV-Infected Adults. Katoto PDMC, Bihehe D, Brand A, Mushi R, Kusinza A, Alwood BW, van Zyl-Smit RN, Tamuzi JL, Sam-Agudu NA, Yotebieng M, Metcalfe J, Theron G, Godri Pollitt KJ, Lesosky M, Vanoirbeek J, Mortimer K, Nawrot T, Nemery B, Nachega JB. Res Sq. 2023 Oct 10; 2023 Oct 10. PMID: 37886487.", + "Assessment of children's personal and land use regression model-estimated exposure to NO(2) in Springfield, Massachusetts. Gao D, Esenther S, Minet L, De Jesus A, Hudson S, Leaderer B, Hatzopoulou M, Godri Pollitt KJ. Sci Total Environ. 2023 Sep 20; 2023 Jun 10. PMID: 37302586.", + "Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study. Rosen Vollmar AK, Lin EZ, Nason SL, Santiago K, Johnson CH, Ma X, Godri Pollitt KJ, Deziel NC. J Expo Sci Environ Epidemiol. 2023 Sep; 2023 Sep 20. PMID: 37730931.", + "Adequacy of stationary measurements as proxies for residential personal exposure to gaseous and particle air pollutants. González Serrano V, Lin EZ, Godri Pollitt KJ, Licina D. Environ Res. 2023 Aug 15; 2023 May 22. PMID: 37224948.", + "Within-city spatial variations in long-term average outdoor oxidant gas concentrations and cardiovascular mortality: Effect modification by oxidative potential in the Canadian Census Health and Environment Cohort. Ripley S, Gao D, Pollitt KJG, Lakey PSJ, Shiraiwa M, Hatzopoulou M, Weichenthal S. Environ Epidemiol. 2023 Aug; 2023 Jun 21. PMID: 37545813.", + "Novel perfluoroalkyl substances (PFAS) discovered in whole blood using automated non-targeted analysis of dried blood spots. Koelmel JP, Lin EZ, Parry E, Stelben P, Rennie EE, Godri Pollitt KJ. Sci Total Environ. 2023 Jul 20; 2023 Apr 24. PMID: 37100129.", + "Trace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots - Demonstration of reproducibility and comparability to venous blood samples. Lin EZ, Nason SL, Zhong A, Fortner J, Godri Pollitt KJ. Sci Total Environ. 2023 Jul 20; 2023 Apr 23. PMID: 37094673.", + "Non-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome. Manz KE, Feerick A, Braun JM, Feng YL, Hall A, Koelmel J, Manzano C, Newton SR, Pennell KD, Place BJ, Godri Pollitt KJ, Prasse C, Young JA. J Expo Sci Environ Epidemiol. 2023 Jul; 2023 Jun 28. PMID: 37380877.", + "Characterizing the external exposome using passive samplers-comparative assessment of chemical exposures using different wearable form factors. Lin EZ, Nichols A, Zhou Y, Koelmel JP, Godri Pollitt KJ. J Expo Sci Environ Epidemiol. 2023 Jul; 2022 Jul 15. PMID: 35840784.", + "Wearable Passive Samplers for Assessing Environmental Exposure to Organic Chemicals: Current Approaches and Future Directions. Okeme JO, Koelmel JP, Johnson E, Lin EZ, Gao D, Pollitt KJG. Curr Environ Health Rep. 2023 Jun; 2023 Feb 23. PMID: 36821032.", + "Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Ding E, Deng F, Fang J, Li T, Hou M, Liu J, Miao K, Yan W, Fang K, Shi W, Fu Y, Liu Y, Dong H, Dong L, Ding C, Liu X, Pollitt KJG, Ji JS, Shi Y, Cai Y, Tang S, Shi X. Environ Health Perspect. 2023 Apr; 2023 Apr 12. PMID: 37042841.", + "Paired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study. Wi CI, Gent JF, Bublitz JT, King KS, Ryu E, Sorrentino K, Plano J, McKay L, Porcher J, Wheeler PH, Chiarella SE, DeWan AT, Godri Pollitt KJ, Sheares BJ, Leaderer B, Juhn YJ. J Prim Care Community Health. 2023 Jan-Dec. PMID: 37243352.", + "Hemoglobin normalization outperforms other methods for standardizing dried blood spot metabolomics: A comparative study. Jain A, Morris M, Lin EZ, Khan SA, Ma X, Deziel NC, Godri Pollitt KJ, Johnson CH. Sci Total Environ. 2023 Jan 1; 2022 Sep 13. PMID: 36113793.", + "Personal airborne chemical exposure and epigenetic ageing biomarkers in healthy Chinese elderly individuals: Evidence from mixture approaches. Shi W, Gao X, Cao Y, Chen Y, Cui Q, Deng F, Yang B, Lin EZ, Fang J, Li T, Tang S, Godri Pollitt KJ, Shi X. Environ Int. 2022 Dec; 2022 Nov 3. PMID: 36375280.", + "Personal air pollutant exposure monitoring in South African children in the VHEMBE birth cohort. DeLay K, Lin EZ, Koelmel JP, Bornman R, Obida M, Chevrier J, Godri Pollitt KJ. Environ Int. 2022 Dec; 2022 Sep 16. PMID: 36260950.", + "Unequal airborne exposure to toxic metals associated with race, ethnicity, and segregation in the USA. Kodros JK, Bell ML, Dominici F, L'Orange C, Godri Pollitt KJ, Weichenthal S, Wu X, Volckens J. Nat Commun. 2022 Nov 1; 2022 Nov 1. PMID: 36319637.", + "An actionable annotation scoring framework for gas chromatography-high-resolution mass spectrometry. Koelmel JP, Xie H, Price EJ, Lin EZ, Manz KE, Stelben P, Paige MK, Papazian S, Okeme J, Jones DP, Barupal D, Bowden JA, Rostkowski P, Pennell KD, Nikiforov V, Wang T, Hu X, Lai Y, Miller GW, Walker DI, Martin JW, Godri Pollitt KJ. Exposome. 2022; 2022 Aug 25. PMID: 36483216.", + "Emerging and Legacy Per- and Polyfluoroalkyl Substances in an Elderly Population in Jinan, China: The Exposure Level, Short-Term Variation, and Intake Assessment. Jia X, Jin Q, Fang J, Shi Y, Hou M, Dong H, Liu Y, Deng F, Zhou Y, Godri Pollitt KJ, Tang S, Shi X, Cai Y. Environ Sci Technol. 2022 Jun 21; 2022 May 18. PMID: 35584234.", + "Predicting Spatial Variations in Multiple Measures of PM(2.5) Oxidative Potential and Magnetite Nanoparticles in Toronto and Montreal, Canada. Ripley S, Minet L, Zalzal J, Godri Pollitt K, Gao D, Lakey PSJ, Shiraiwa M, Maher BA, Hatzopoulou M, Weichenthal S. Environ Sci Technol. 2022 Jun 7; 2021 Dec 29. PMID: 34965092.", + "Corrigendum to \"Exposure to organophosphate esters in elderly people: Relationships of OPE body burdens with indoor air and dust concentrations and food consumption\" [Environ. Int. 157 (2021) 106803]. Hou M, Fang J, Shi Y, Tang S, Dong H, Liu Y, Deng F, Giesy JP, Pollitt KJG, Cai Y, Shi X. Environ Int. 2022 Jun; 2022 May 2. PMID: 35512529.", + "Changes in Sewage Sludge Chemical Signatures During a COVID-19 Community Lockdown, Part 2: Nontargeted Analysis of Sludge and Evaluation with COVID-19 Metrics. Nason SL, Lin E, Godri Pollitt KJ, Peccia J. Environ Toxicol Chem. 2022 May; 2021 Nov 2. PMID: 34729807.", + "Assessing the External Exposome Using Wearable Passive Samplers and High-Resolution Mass Spectrometry among South African Children Participating in the VHEMBE Study. Koelmel JP, Lin EZ, DeLay K, Williams AJ, Zhou Y, Bornman R, Obida M, Chevrier J, Godri Pollitt KJ. Environ Sci Technol. 2022 Feb 15; 2022 Jan 28. PMID: 35089017.", + "Development and Application of a Polydimethylsiloxane-Based Passive Air Sampler to Assess Personal Exposure to SARS-CoV-2. Angel DM, Gao D, DeLay K, Lin EZ, Eldred J, Arnold W, Santiago R, Redlich C, Martinello RA, Sherman JD, Peccia J, Godri Pollitt KJ. Environ Sci Technol Lett. 2022 Feb 8; 2022 Jan 11. PMID: 37566382.", + "Room-level ventilation in schools and universities. McNeill VF, Corsi R, Huffman JA, King C, Klein R, Lamore M, Maeng DY, Miller SL, Lee Ng N, Olsiewski P, Godri Pollitt KJ, Segalman R, Sessions A, Squires T, Westgate S. Atmos Environ X. 2022 Jan; 2022 Jan 26. PMID: 35098105.", + "FluoroMatch 2.0-making automated and comprehensive non-targeted PFAS annotation a reality. Koelmel JP, Stelben P, McDonough CA, Dukes DA, Aristizabal-Henao JJ, Nason SL, Li Y, Sternberg S, Lin E, Beckmann M, Williams AJ, Draper J, Finch JP, Munk JK, Deigl C, Rennie EE, Bowden JA, Godri Pollitt KJ. Anal Bioanal Chem. 2022 Jan; 2021 May 20. PMID: 34014358.", + "Prevalence and Implications of Per- and Polyfluoroalkyl Substances (PFAS) in Settled Dust. Savvaides T, Koelmel JP, Zhou Y, Lin EZ, Stelben P, Aristizabal-Henao JJ, Bowden JA, Godri Pollitt KJ. Curr Environ Health Rep. 2021 Dec; 2022 Jan 5. PMID: 34985714.", + "The exposome in practice: an exploratory panel study of biomarkers of air pollutant exposure in Chinese people aged 60-69 years (China BAPE Study). Tang S, Li T, Fang J, Chen R, Cha Y, Wang Y, Zhu M, Zhang Y, Chen Y, Du Y, Yu T, Thompson DC, Godri Pollitt KJ, Vasiliou V, Ji JS, Kan H, Zhang JJ, Shi X. Environ Int. 2021 Dec; 2021 Sep 12. PMID: 34525388.", + "Exposure to organophosphate esters in elderly people: Relationships of OPE body burdens with indoor air and dust concentrations and food consumption. Hou M, Fang J, Shi Y, Tang S, Dong H, Liu Y, Deng F, Giesy JP, Godri Pollitt KJ, Cai Y, Shi X. Environ Int. 2021 Dec; 2021 Aug 5. PMID: 34365320.", + "Exploring personal chemical exposures in China with wearable air pollutant monitors: A repeated-measure study in healthy older adults in Jinan, China. Guo P, Lin EZ, Koelmel JP, Ding E, Gao Y, Deng F, Dong H, Liu Y, Cha Y, Fang J, Shi X, Tang S, Godri Pollitt KJ. Environ Int. 2021 Nov; 2021 Jun 19. PMID: 34153889.", + "An accessible method for screening aerosol filtration identifies poor-performing commercial masks and respirators. Schilling K, Gentner DR, Wilen L, Medina A, Buehler C, Perez-Lorenzo LJ, Pollitt KJG, Bergemann R, Bernardo N, Peccia J, Wilczynski V, Lattanza L. J Expo Sci Environ Epidemiol. 2021 Nov; 2020 Aug 6. PMID: 32764709.", + "Survey of airborne organic compounds in residential communities near a natural gas compressor station: Response to community concern. Vollet Martin KA, Lin EZ, Hilbert TJ, Godri Pollitt KJ, Haynes EN. Environ Adv. 2021 Oct; 2021 Jun 13. PMID: 36185588.", + "Predicting Spatial Variations in Multiple Measures of Oxidative Burden for Outdoor Fine Particulate Air Pollution across Canada. Xu JW, Martin RV, Evans GJ, Umbrio D, Traub A, Meng J, van Donkelaar A, You H, Kulka R, Burnett RT, Godri Pollitt KJ, Weichenthal S. Environ Sci Technol. 2021 Jul 20; 2021 Jul 9. PMID: 34241996.", + "Yale School of Public Health Symposium: An overview of the challenges and opportunities associated with per- and polyfluoroalkyl substances (PFAS). Hagstrom AL, Anastas P, Boissevain A, Borrel A, Deziel NC, Fenton SE, Fields C, Fortner JD, Franceschi-Hofmann N, Frigon R, Jin L, Kim JH, Kleinstreuer NC, Koelmel J, Lei Y, Liew Z, Ma X, Mathieu L, Nason SL, Organtini K, Oulhote Y, Pociu S, Godri Pollitt KJ, Saiers J, Thompson DC, Toal B, Weiner EJ, Whirledge S, Zhang Y, Vasiliou V. Sci Total Environ. 2021 Jul 15; 2021 Mar 3. PMID: 33714836.", + "A Novel Technique for Redox Lipidomics Using Mass Spectrometry: Application on Vegetable Oils Used to Fry Potatoes. Koelmel JP, Aristizabal-Henao JJ, Ni Z, Fedorova M, Kato S, Otoki Y, Nakagawa K, Lin EZ, Godri Pollitt KJ, Vasiliou V, Guingab JD, Garrett TJ, Williams TL, Bowden JA, Penumetcha M. J Am Soc Mass Spectrom. 2021 Jul 7; 2021 Jun 7. PMID: 34096708.", + "Solid fuels use for cooking and sleep health in adults aged 45 years and older in China. Yu H, Luo J, Chen K, Pollitt KJG, Liew Z. Sci Rep. 2021 Jun 25; 2021 Jun 25. PMID: 34172775.", + "Software Comparison for Nontargeted Analysis of PFAS in AFFF-Contaminated Soil. Nason SL, Koelmel J, Zuverza-Mena N, Stanley C, Tamez C, Bowden JA, Godri Pollitt KJ. J Am Soc Mass Spectrom. 2021 Apr 7; 2020 Nov 23. PMID: 33226225.", + "Head, Shoulders, Knees, and Toes: Placement of Wearable Passive Samplers Alters Exposure Profiles Observed. Koelmel JP, Lin EZ, Nichols A, Guo P, Zhou Y, Godri Pollitt KJ. Environ Sci Technol. 2021 Mar 16; 2021 Feb 24. PMID: 33625210.", + "Use of Exposomic Methods Incorporating Sensors in Environmental Epidemiology. Doherty BT, Koelmel JP, Lin EZ, Romano ME, Godri Pollitt KJ. Curr Environ Health Rep. 2021 Mar; 2021 Feb 10. PMID: 33569731.", + "Use of Untargeted Metabolomics to Explore the Air Pollution-Related Disease Continuum. Jin L, Godri Pollitt KJ, Liew Z, Rosen Vollmar AK, Vasiliou V, Johnson CH, Zhang Y. Curr Environ Health Rep. 2021 Mar; 2021 Jan 9. PMID: 33420964.", + "Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community. Katoto PDMC, Kayembe-Kitenge T, Pollitt KJG, Martens DS, Ghosh M, Nachega JB, Nemery B, Nawrot TS. Sci Rep. 2021 Feb 17; 2021 Feb 17. PMID: 33597559.", + "Exploring the external exposome using wearable passive samplers - The China BAPE study. Koelmel JP, Lin EZ, Guo P, Zhou J, He J, Chen A, Gao Y, Deng F, Dong H, Liu Y, Cha Y, Fang J, Beecher C, Shi X, Tang S, Godri Pollitt KJ. Environ Pollut. 2021 Feb 1; 2020 Dec 6. PMID: 33360595.", + "Reopening Schools After a Novel Coronavirus Surge. Li D, Lin EZ, Brault MA, Paquette J, Vermund SH, Godri Pollitt KJ. Adv Exp Med Biol. 2021. PMID: 33973212.", + "COVID-19 update: the first 6 months of the pandemic. Novelli G, Biancolella M, Mehrian-Shai R, Erickson C, Godri Pollitt KJ, Vasiliou V, Watt J, Reichardt JKV. Hum Genomics. 2020 Dec 23; 2020 Dec 23. PMID: 33357238.", + "Addressing the challenges of E-cigarette safety profiling by assessment of pulmonary toxicological response in bronchial and alveolar mucosa models. Ganguly K, Nordström A, Thimraj TA, Rahman M, Ramström M, Sompa SI, Lin EZ, O'Brien F, Koelmel J, Ernstgård L, Johanson G, Pollitt KJG, Palmberg L, Upadhyay S. Sci Rep. 2020 Nov 24; 2020 Nov 24. PMID: 33235237.", + "Performance analysis of portable HEPA filters and temporary plastic anterooms on the spread of surrogate coronavirus. Mousavi ES, Godri Pollitt KJ, Sherman J, Martinello RA. Build Environ. 2020 Oct; 2020 Aug 13. PMID: 32834420.", + "Clinical, Epidemiological and Experimental Approaches to Assess Adverse Health Outcomes of Indoor Biomass Smoke Exposure: Conclusions from An Indo-Swedish Workshop in Mysuru, January 2020. Padukudru Anand M, Larsson K, Johanson G, Phuleria HC, Ravindra PV, Ernstgård L, Mabalirajan U, Krishna M, Palmberg L, Pollitt KJG, Upadhyay S, Ganguly K. Toxics. 2020 Sep 5; 2020 Sep 5. PMID: 32899560.", + "Toward Comprehensive Per- and Polyfluoroalkyl Substances Annotation Using FluoroMatch Software and Intelligent High-Resolution Tandem Mass Spectrometry Acquisition. Koelmel JP, Paige MK, Aristizabal-Henao JJ, Robey NM, Nason SL, Stelben PJ, Li Y, Kroeger NM, Napolitano MP, Savvaides T, Vasiliou V, Rostkowski P, Garrett TJ, Lin E, Deigl C, Jobst K, Townsend TG, Godri Pollitt KJ, Bowden JA. Anal Chem. 2020 Aug 18; 2020 Aug 6. PMID: 32806901.", + "COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission. Godri Pollitt KJ, Peccia J, Ko AI, Kaminski N, Dela Cruz CS, Nebert DW, Reichardt JKV, Thompson DC, Vasiliou V. Hum Genomics. 2020 May 12; 2020 May 12. PMID: 32398162.", + "Ambient particulate matter oxidative potential: Chemical determinants, associated health effects, and strategies for risk management. Gao D, Ripley S, Weichenthal S, Godri Pollitt KJ. Free Radic Biol Med. 2020 May 1; 2020 May 11. PMID: 32430137.", + "Environmental lipidomics: understanding the response of organisms and ecosystems to a changing world. Koelmel JP, Napolitano MP, Ulmer CZ, Vasiliou V, Garrett TJ, Yost RA, Prasad MNV, Godri Pollitt KJ, Bowden JA. Metabolomics. 2020 Apr 19; 2020 Apr 19. PMID: 32307636.", + "1,4-Dioxane as an emerging water contaminant: State of the science and evaluation of research needs. Godri Pollitt KJ, Kim JH, Peccia J, Elimelech M, Zhang Y, Charkoftaki G, Hodges B, Zucker I, Huang H, Deziel NC, Murphy K, Ishii M, Johnson CH, Boissevain A, O'Keefe E, Anastas PT, Orlicky D, Thompson DC, Vasiliou V. Sci Total Environ. 2019 Nov 10; 2019 Jun 28. PMID: 31302550.", + "Assessment of the in vitro toxicity of the disinfection byproduct 2,6-dichloro-1,4-benzoquinone and its transformed derivatives. Hung S, Mohan A, Reckhow DA, Godri Pollitt KJ. Chemosphere. 2019 Nov; 2019 Jun 12. PMID: 31519098.", + "Biodiesel fuels: A greener diesel? A review from a health perspective. Godri Pollitt KJ, Chhan D, Rais K, Pan K, Wallace JS. Sci Total Environ. 2019 Oct 20; 2019 Jun 8. PMID: 31726536.", + "Long-term leaching of arsenic from pressure-treated playground structures in the northeastern United States. Deramos King CM, Dozier CS, Campbell JL, Curry ED, Godri Pollitt KJ. Sci Total Environ. 2019 Mar 15; 2018 Nov 22. PMID: 30530151.", + "Carbonaceous aerosol sampling of gasoline direct injection engine exhaust with an integrated organic gas and particle sampler. Zimmerman N, Rais K, Jeong CH, Pant P, Delgado-Saborit JM, Wallace JS, Evans GJ, Brook JR, Godri Pollitt KJ. Sci Total Environ. 2019 Feb 20; 2018 Oct 26. PMID: 30586812.", + "Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study. Liu L, Urch B, Szyszkowicz M, Evans G, Speck M, Van Huang A, Leingartner K, Shutt RH, Pelletier G, Gold DR, Brook JR, Godri Pollitt K, Silverman FS. Environ Int. 2018 Dec; 2018 Nov 9. PMID: 30420132.", + "Fine Particulate Air Pollution and Adverse Birth Outcomes: Effect Modification by Regional Nonvolatile Oxidative Potential. Lavigne É, Burnett RT, Stieb DM, Evans GJ, Godri Pollitt KJ, Chen H, van Rijswijk D, Weichenthal S. Environ Health Perspect. 2018 Jul; 2018 Jul 31. PMID: 30073952.", + "Comparison of Airway Responses Induced in a Mouse Model by the Gas and Particulate Fractions of Gasoline Direct Injection Engine Exhaust. Maikawa CL, Zimmerman N, Ramos M, Shah M, Wallace JS, Pollitt KJG. Int J Environ Res Public Health. 2018 Mar 1; 2018 Mar 1. PMID: 29494515.", + "Biomonitoring-based exposure assessment of benzene, toluene, ethylbenzene and xylene among workers at petroleum distribution facilities. Heibati B, Godri Pollitt KJ, Charati JY, Ducatman A, Shokrzadeh M, Karimi A, Mohammadyan M. Ecotoxicol Environ Saf. 2018 Mar; 2017 Nov 13. PMID: 29145162.", + "BTEX exposure assessment and quantitative risk assessment among petroleum product distributors. Heibati B, Pollitt KJG, Karimi A, Yazdani Charati J, Ducatman A, Shokrzadeh M, Mohammadyan M. Ecotoxicol Environ Saf. 2017 Oct; 2017 Jun 27. PMID: 28666218.", + "Assessment of indoor and outdoor particulate air pollution at an urban background site in Iran. Mohammadyan M, Ghoochani M, Kloog I, Abdul-Wahab SA, Yetilmezsoy K, Heibati B, Godri Pollitt KJ. Environ Monit Assess. 2017 May; 2017 Apr 27. PMID: 28451957.", + "Murine precision-cut lung slices exhibit acute responses following exposure to gasoline direct injection engine emissions. Maikawa CL, Zimmerman N, Rais K, Shah M, Hawley B, Pant P, Jeong CH, Delgado-Saborit JM, Volckens J, Evans G, Wallace JS, Godri Pollitt KJ. Sci Total Environ. 2016 Oct 15; 2016 Jun 29. PMID: 27369091.", + "Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma. Maikawa CL, Weichenthal S, Wheeler AJ, Dobbin NA, Smargiassi A, Evans G, Liu L, Goldberg MS, Pollitt KJ. Environ Health Perspect. 2016 Oct; 2016 May 6. PMID: 27152705.", + "Trace metal exposure is associated with increased exhaled nitric oxide in asthmatic children. Godri Pollitt KJ, Maikawa CL, Wheeler AJ, Weichenthal S, Dobbin NA, Liu L, Goldberg MS. Environ Health. 2016 Sep 1; 2016 Sep 1. PMID: 27586245.", + "Fine Particulate Matter and Emergency Room Visits for Respiratory Illness. Effect Modification by Oxidative Potential. Weichenthal SA, Lavigne E, Evans GJ, Godri Pollitt KJ, Burnett RT. Am J Respir Crit Care Med. 2016 Sep 1. PMID: 26963193.", + "Oxidative burden of fine particulate air pollution and risk of cause-specific mortality in the Canadian Census Health and Environment Cohort (CanCHEC). Weichenthal S, Crouse DL, Pinault L, Godri-Pollitt K, Lavigne E, Evans G, van Donkelaar A, Martin RV, Burnett RT. Environ Res. 2016 Apr; 2015 Dec 30. PMID: 26745732.", + "The PM10 fraction of road dust in the UK and India: Characterization, source profiles and oxidative potential. Pant P, Baker SJ, Shukla A, Maikawa C, Godri Pollitt KJ, Harrison RM. Sci Total Environ. 2015 Oct 15; 2015 May 29. PMID: 26033216.", + "Syk mediates airway contractility independent of leukocyte function. Wang X, Khanna N, Wu J, Godri Pollitt K, Evans GJ, Chow CW, Scott JA. Allergy. 2015 Apr; 2015 Jan 26. PMID: 25556883.", + "PM2.5, oxidant defence and cardiorespiratory health: a review. Weichenthal SA, Godri-Pollitt K, Villeneuve PJ. Environ Health. 2013 May 4; 2013 May 4. PMID: 23641908.", + "Acute nasal pro-inflammatory response to air pollution depends on characteristics other than particle mass concentration or oxidative potential: the RAPTES project. Steenhof M, Mudway IS, Gosens I, Hoek G, Godri KJ, Kelly FJ, Harrison RM, Pieters RH, Cassee FR, Lebret E, Brunekreef BA, Strak M, Janssen NA. Occup Environ Med. 2013 May; 2013 Feb 21. PMID: 23428835.", + "Components of ambient air pollution affect thrombin generation in healthy humans: the RAPTES project. Strak M, Hoek G, Steenhof M, Kilinc E, Godri KJ, Gosens I, Mudway IS, van Oerle R, Spronk HM, Cassee FR, Kelly FJ, Harrison RM, Brunekreef B, Lebret E, Janssen NA. Occup Environ Med. 2013 May; 2013 Feb 1. PMID: 23378445.", + "Composition of PM affects acute vascular inflammatory and coagulative markers - the RAPTES project. Strak M, Hoek G, Godri KJ, Gosens I, Mudway IS, van Oerle R, Spronk HM, Cassee FR, Lebret E, Kelly FJ, Harrison RM, Brunekreef B, Steenhof M, Janssen NA. PLoS One. 2013; 2013 Mar 13. PMID: 23516583.", + "Airborne particulate matter and acute lung inflammation: Strak et al. Respond. Strak M, Janssen NA, Gosens I, Cassee FR, Lebret E, Godri KJ, Mudway IS, Kelly FJ, Harrison RM, Brunekreef B, Steenhof M, Hoek G. Environ Health Perspect. 2013 Jan. PMID: 23287312.", + "Respiratory health effects of airborne particulate matter: the role of particle size, composition, and oxidative potential-the RAPTES project. Strak M, Janssen NA, Godri KJ, Gosens I, Mudway IS, Cassee FR, Lebret E, Kelly FJ, Harrison RM, Brunekreef B, Steenhof M, Hoek G. Environ Health Perspect. 2012 Aug; 2012 May 2. PMID: 22552951.", + "In vitro toxicity of particulate matter (PM) collected at different sites in the Netherlands is associated with PM composition, size fraction and oxidative potential--the RAPTES project. Steenhof M, Gosens I, Strak M, Godri KJ, Hoek G, Cassee FR, Mudway IS, Kelly FJ, Harrison RM, Lebret E, Brunekreef B, Janssen NA, Pieters RH. Part Fibre Toxicol. 2011 Sep 2; 2011 Sep 2. PMID: 21888644.", + "Increased oxidative burden associated with traffic component of ambient particulate matter at roadside and urban background schools sites in London. Godri KJ, Harrison RM, Evans T, Baker T, Dunster C, Mudway IS, Kelly FJ. PLoS One. 2011; 2011 Jul 27. PMID: 21818283.", + "Particulate oxidative burden associated with firework activity. Godri KJ, Green DC, Fuller GW, Dall'Osto M, Beddows DC, Kelly FJ, Harrison RM, Mudway IS. Environ Sci Technol. 2010 Nov 1. PMID: 20886897.", + "Particulate matter oxidative potential from waste transfer station activity. Godri KJ, Duggan ST, Fuller GW, Baker T, Green D, Kelly FJ, Mudway IS. Environ Health Perspect. 2010 Apr. PMID: 20368130.", + "YSPH Calendar", + "Maps & Directions", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Powers Lab", + "lab_url": "https://medicine.yale.edu/lab/powers/", + "research_bio": "INFORMATION FOR Here in the lab, we work to find new approaches to understanding the symptoms of mental illness in a way that leads to new methods of diagnosis, risk stratification, and treatment. Our research combines advanced methods in psychophysics, neuroimaging, and computational modeling with detailed interviewing and phenomenological analysis to understand how the symptoms of psychosis emerge. Our hope is that, by understanding the processes that give rise to the most distressing aspects of psychotic illness, we might intervene directly in these processes at the earliest possible time, bending our patients' clinical trajectories toward better functioning and recovery. In addition to understanding how these symptoms emerge, we aim to gain a deeper understanding of the factors that protect people at clinical high risk of psychosis against the development of the illness. This effort entails working with people who hear voices but do not seek--and, often, do not require--the help of a psychiatrist or other mental health professionals. By learning from these experiences, we hope to develop new ways of helping those with voices that are distressing. Because our work ranges from qualitative analysis of clinical interviews to highly quantitative computational methods, our lab welcomes people of all skill levels who share a passion for understanding the symptoms of psychosis. The Powers Lab uses methods as diverse as computational modeling, functional imaging, electrophysiology, psychophysics, and qualitative analysis to understand psychotic experiences as they emerge. We are closely linked to the PRIME Psychosis Risk Research Clinic at Yale, where Dr. Powers works with young people at clinical high risk of developing psychosis. Our goal is to further our understanding of the symptoms that impact our patients and to bring that understanding to bear on the development of new diagnostic and treatment approaches for those distressed or impaired by their experiences. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/powers/publications", + "publications": [ + "Yale School of Medicine /", + "Psychiatry /", + "People", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "People", + "Publications", + "", + "", + "", + "", + "", + "", + "Sterling Hall of Medicine 333 Cedar Street New Haven, CT 06520-8023 Maps & Directions", + "Calendar", + "Contact Us", + "", + "", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Qyang Lab", + "lab_url": "https://medicine.yale.edu/lab/qyang/", + "research_bio": "INFORMATION FOR Copy Link Our stem cell and regenerative medicine laboratory focuses on establishing novel cellular, tissue engineered, and animal models of human cardiovascular disease for the purpose of elucidating causative mechanisms and identifying therapeutic interventions to treat these diseases. Through a close collaboration with several clinicians at Yale, we are able to procure cells from healthy subjects and from those with clinically manifesting cardiovascular diseases. These cells include dermal fibroblasts derived from skin punch biopsies and peripheral mononuclear blood cells, which are reprogrammed into induced pluripotent stem cells (iPSCs) by introducing stem cell factors. iPSCs are self-renewable indefinitely and can differentiate into functional cardiovascular cells. Our unique position, made possible by Yale’s clinical resources, gives us the ability to derive unlimited numbers of patient specific cardiovascular cells for use in our investigations into cardiovascular disease mechanisms and the discovery of potential therapeutic treatments by performing high-throughput drug screening. This research paradigm also places our group in a great position to generate autologous, allogeneic or hypoimmunogenic “universal” stem cell based cardiovascular tissues for organ repair. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/qyang/publications/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Cardiovascular Medicine /", + "Research", + "Photos", + "People", + "Contact", + "Publications", + "Funding", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "Funding", + "Photos", + "Contact", + "", + "", + "", + "", + "", + "", + "SHP2 genetic variants in NSML-associated RASopathies disrupt the PZR-IRX transcription factor signaling axis. Perla S, Stiegler AL, Yi JS, Enyenihi L, Zhang L, Riaz M, An E, Qyang Y, Boggon TJ, Bennett AM. Proc Natl Acad Sci U S A. 2025 Sep 2; 2025 Aug 25. PMID: 40854126.", + "Cardiac macrophage: Insights from murine models to translational potential for human studies. Liu Y, Wang TT, Lu Y, Riaz M, Qyang Y. J Mol Cell Cardiol. 2025 Jul; 2025 May 10. PMID: 40354877.", + "Advanced tissue-engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes. Luo H, Anderson CW, Li X, Lu Y, Hoareau M, Xing Q, Fooladi S, Liu Y, Xu Z, Park J, Fallon ME, Thomas J, Gruber PJ, Elder RW, Mak M, Riaz M, Campbell SG, Qyang Y. Acta Biomater. 2025 Jun 27; 2025 Jun 27. PMID: 40582540.", + "Application of instant assembly of collagen to bioprint cardiac tissues. Xiao H, Liang Z, Gong X, Jordan SN, Rossello-Martinez A, Gokhan I, Li X, Wen Z, Lee S, Campbell SG, Qyang Y, Mak M. APL Bioeng. 2025 Jun; 2025 Jun 12. PMID: 40520649.", + "Generation of Orthogonal Gradients of the Matrix Stiffness and Chemotactic Cues in a Suspended Array of Hydrogel to Study hMSCs Migration. Xu Z, Ponek A, Thomas J, Qyang Y. ACS Sens. 2025 Mar 28; 2025 Feb 28. PMID: 40021359.", + "Advancements in techniques for human iPSC-derived cardiomyocytes maturation: mechanical and electrical stimulation approaches. Lu Y, Liu Y, Yan Y, Fooladi S, Qyang Y. Biophys Rev. 2025 Feb; 2025 Jan 3. PMID: 40060015.", + "Vascular endothelial cells derived from transgene-free pig induced pluripotent stem cells for vascular tissue engineering. Batty L, Park J, Qin L, Riaz M, Lin Y, Xu Z, Gao X, Li X, Lopez C, Zhang W, Hoareau M, Fallon ME, Huang Y, Luo H, Luo J, Ménoret S, Li P, Jiang Z, Smith P, Sachs DH, Tellides G, Ignacio Anegon, Pober JS, Liu P, Qyang Y. Acta Biomater. 2025 Jan 24; 2024 Dec 15. PMID: 39681154.", + "Fully biologic endothelialized-tissue-engineered vascular conduits provide antithrombotic function and graft patency. Park J, Riaz M, Qin L, Zhang W, Batty L, Fooladi S, Kural MH, Li X, Luo H, Xu Z, Wang J, Banno K, Gu SX, Yuan Y, Anderson CW, Ellis MW, Zhou J, Luo J, Shi X, Shin JH, Liu Y, Lee S, Yoder MC, Elder RW, Mak M, Thorn S, Sinusas A, Gruber PJ, Hwa J, Tellides G, Niklason LE, Qyang Y. Cell Stem Cell. 2025 Jan 2; 2024 Dec 6. PMID: 39644899.", + "UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling. Harrison AG, Yang D, Cahoon JG, Geng T, Cao Z, Karginov TA, Hu Y, Li X, Chiari CC, Qyang Y, Vella AT, Fan Z, Vanaja SK, Rathinam VA, Witczak CA, Bogan JS, Wang P. Nat Immunol. 2024 Dec; 2024 Nov 20. PMID: 39567760.", + "De Novo Elastin Assembly Alleviates Development of Supravalvular Aortic Stenosis-Brief Report. Ellis MW, Riaz M, Huang Y, Anderson CW, Hoareau M, Li X, Luo H, Lee S, Park J, Luo J, Batty LD, Huang Q, Lopez CA, Reinhardt DP, Tellides G, Qyang Y. Arterioscler Thromb Vasc Biol. 2024 Jul; 2024 May 16. PMID: 38752350.", + "UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling. Wang P, Harrison A, Yang D, Cahoon J, Geng T, Cao Z, Karginov T, Chiari C, Li X, Qyang Y, Vella A, Fan Z, Vanaja SK, Rathinam V, Witczak C, Bogan J. Res Sq. 2024 Jun 4; 2024 Jun 4. PMID: 38883790.", + "The relationship between elastin cross linking and alveolar wall rupture in human pulmonary emphysema. Fagiola M, Reznik S, Riaz M, Qyang Y, Lee S, Avella J, Turino G, Cantor J. Am J Physiol Lung Cell Mol Physiol. 2023 Jun 1; 2023 Apr 4. PMID: 37014816.", + "Signaling network model of cardiomyocyte morphological changes in familial cardiomyopathy. Khalilimeybodi A, Riaz M, Campbell SG, Omens JH, McCulloch AD, Qyang Y, Saucerman JJ. J Mol Cell Cardiol. 2023 Jan; 2022 Nov 10. PMID: 36370475.", + "Muscle LIM Protein Force-Sensing Mediates Sarcomeric Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy. Riaz M, Park J, Sewanan LR, Ren Y, Schwan J, Das SK, Pomianowski PT, Huang Y, Ellis MW, Luo J, Liu J, Song L, Chen IP, Qiu C, Yazawa M, Tellides G, Hwa J, Young LH, Yang L, Marboe CC, Jacoby DL, Campbell SG, Qyang Y. Circulation. 2022 Apr 19; 2022 Apr 6. PMID: 35384713.", + "Readily Available Tissue-Engineered Vascular Grafts Derived From Human Induced Pluripotent Stem Cells. Luo J, Qin L, Park J, Kural MH, Huang Y, Shi X, Riaz M, Wang J, Ellis MW, Anderson CW, Yuan Y, Ren Y, Yoder MC, Tellides G, Niklason LE, Qyang Y. Circ Res. 2022 Mar 18; 2022 Feb 22. PMID: 35189711.", + "Epigallocatechin gallate facilitates extracellular elastin fiber formation in induced pluripotent stem cell derived vascular smooth muscle cells for tissue engineering. Ellis MW, Riaz M, Huang Y, Anderson CW, Luo J, Park J, Lopez CA, Batty LD, Gibson KH, Qyang Y. J Mol Cell Cardiol. 2022 Feb; 2021 Dec 31. PMID: 34979103.", + "Methods for Differentiating hiPSCs into Vascular Smooth Muscle Cells. Li ML, Luo J, Ellis MW, Riaz M, Ajaj Y, Qyang Y. Methods Mol Biol. 2022. PMID: 34591296.", + "Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation. Sewanan LR, Park J, Rynkiewicz MJ, Racca AW, Papoutsidakis N, Schwan J, Jacoby DL, Moore JR, Lehman W, Qyang Y, Campbell SG. J Gen Physiol. 2021 Sep 6; 2021 Jul 28. PMID: 34319370.", + "An ex vivo physiologic and hyperplastic vessel culture model to study intra-arterial stent therapies. Wang J, Kural MH, Wu J, Leiby KL, Mishra V, Lysyy T, Li G, Luo J, Greaney A, Tellides G, Qyang Y, Huang N, Niklason LE. Biomaterials. 2021 Aug; 2021 May 29. PMID: 34087584.", + "PECUU-ECM Patches: The Future of Ischemic Heart Disease Repair. Ajaj Y, Akingbesote ND, Qyang Y. JACC Basic Transl Sci. 2021 May; 2021 May 24. PMID: 34101774.", + "Human-Induced Pluripotent Stem-Cell-Derived Smooth Muscle Cells Increase Angiogenesis to Treat Hindlimb Ischemia. Gao X, Gao M, Gorecka J, Langford J, Liu J, Luo J, Taniguchi R, Matsubara Y, Liu H, Guo L, Gu Y, Qyang Y, Dardik A. Cells. 2021 Apr 2; 2021 Apr 2. PMID: 33918299.", + "Shortening Velocity Causes Myosin Isoform Shift in Human Engineered Heart Tissues. Ng R, Sewanan LR, Stankey P, Li X, Qyang Y, Campbell S. Circ Res. 2021 Jan 22; 2020 Nov 13. PMID: 33183160.", + "Efficient Differentiation of Human Induced Pluripotent Stem Cells into Endothelial Cells under Xenogeneic-free Conditions for Vascular Tissue Engineering. Luo J, Shi X, Lin Y, Yuan Y, Kural MH, Wang J, Ellis MW, Anderson CW, Zhang SM, Riaz M, Niklason LE, Qyang Y. Acta Biomater. 2021 Jan 1; 2020 Nov 6. PMID: 33166710.", + "Xenogeneic-free generation of vascular smooth muscle cells from human induced pluripotent stem cells for vascular tissue engineering. Luo J, Lin Y, Shi X, Li G, Kural MH, Anderson CW, Ellis MW, Riaz M, Tellides G, Niklason LE, Qyang Y. Acta Biomater. 2021 Jan 1; 2020 Oct 29. PMID: 33130306.", + "Contractile work directly modulates mitochondrial protein levels in human engineered heart tissues. Ng R, Sewanan LR, Brill AL, Stankey P, Li X, Qyang Y, Ehrlich BE, Campbell SG. Am J Physiol Heart Circ Physiol. 2020 Jun 1; 2020 May 8. PMID: 32383992.", + "Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human iPSCs. Luo J, Qin L, Zhao L, Gui L, Ellis MW, Huang Y, Kural MH, Clark JA, Ono S, Wang J, Yuan Y, Zhang SM, Cong X, Li G, Riaz M, Lopez C, Hotta A, Campbell S, Tellides G, Dardik A, Niklason LE, Qyang Y. Cell Stem Cell. 2020 Feb 6; 2020 Jan 16. PMID: 31956039.", + "Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing. Gorecka J, Gao X, Fereydooni A, Dash BC, Luo J, Lee SR, Taniguchi R, Hsia HC, Qyang Y, Dardik A. Regen Med. 2020 Feb; 2020 Mar 31. PMID: 32228292.", + "Modular design of a tissue engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes. Park J, Anderson CW, Sewanan LR, Kural MH, Huang Y, Luo J, Gui L, Riaz M, Lopez CA, Ng R, Das SK, Wang J, Niklason L, Campbell SG, Qyang Y. Acta Biomater. 2020 Jan 15; 2019 Oct 19. PMID: 31634626.", + "Polydopamine and collagen coated micro-grated polydimethylsiloxane for human mesenchymal stem cell culture. Sharma D, Jia W, Long F, Pati S, Chen Q, Qyang Y, Lee B, Choi CK, Zhao F. Bioact Mater. 2019 Dec; 2019 Feb 21. PMID: 30873506.", + "Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes. Sewanan LR, Schwan J, Kluger J, Park J, Jacoby DL, Qyang Y, Campbell SG. JACC Basic Transl Sci. 2019 Aug; 2019 Jul 24. PMID: 31468004.", + "Patient mutations linked to arrhythmogenic cardiomyopathy enhance calpain-mediated desmoplakin degradation. Ng R, Manring H, Papoutsidakis N, Albertelli T, Tsai N, See CJ, Li X, Park J, Stevens TL, Bobbili PJ, Riaz M, Ren Y, Stoddard CE, Janssen PM, Bunch TJ, Hall SP, Lo YC, Jacoby DL, Qyang Y, Wright N, Ackermann MA, Campbell SG. JCI Insight. 2019 Jun 13; 2019 Jun 13. PMID: 31194698.", + "Sarcomere-Directed Calcium Reporters in Cardiomyocytes. Campbell SG, Qyang Y, Hinson JT. Circ Res. 2019 Apr 12. PMID: 30973804.", + "The potential and limitations of induced pluripotent stem cells to achieve wound healing. Gorecka J, Kostiuk V, Fereydooni A, Gonzalez L, Luo J, Dash B, Isaji T, Ono S, Liu S, Lee SR, Xu J, Liu J, Taniguchi R, Yastula B, Hsia HC, Qyang Y, Dardik A. Stem Cell Res Ther. 2019 Mar 12; 2019 Mar 12. PMID: 30867069.", + "Modeling elastin-associated vasculopathy with patient induced pluripotent stem cells and tissue engineering. Ellis MW, Luo J, Qyang Y. Cell Mol Life Sci. 2019 Mar; 2018 Nov 20. PMID: 30460472.", + "Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering. Luo J, Qin L, Kural MH, Schwan J, Li X, Bartulos O, Cong XQ, Ren Y, Gui L, Li G, Ellis MW, Li P, Kotton DN, Dardik A, Pober JS, Tellides G, Rolle M, Campbell S, Hawley RJ, Sachs DH, Niklason LE, Qyang Y. Biomaterials. 2017 Dec; 2017 Sep 19. PMID: 28942128.", + "mTOR (Mechanistic Target of Rapamycin) Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice. Jiao Y, Li G, Li Q, Ali R, Qin L, Li W, Qyang Y, Greif DM, Geirsson A, Humphrey JD, Tellides G. Arterioscler Thromb Vasc Biol. 2017 Sep; 2017 Jul 27. PMID: 28751568.", + "Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells. Sivarapatna A, Ghaedi M, Xiao Y, Han E, Aryal B, Zhou J, Fernandez-Hernando C, Qyang Y, Hirschi KK, Niklason LE. Cell Transplant. 2017 Aug. PMID: 28901188.", + "Stem Cells in Cardiovascular Medicine: the Road to Regenerative Therapies. Anderson CW, Boardman N, Luo J, Park J, Qyang Y. Curr Cardiol Rep. 2017 Apr. PMID: 28324469.", + "Alk2/ACVR1 and Alk3/BMPR1A Provide Essential Function for Bone Morphogenetic Protein-Induced Retinal Angiogenesis. Lee HW, Chong DC, Ola R, Dunworth WP, Meadows S, Ka J, Kaartinen VM, Qyang Y, Cleaver O, Bautch VL, Eichmann A, Jin SW. Arterioscler Thromb Vasc Biol. 2017 Apr; 2017 Feb 23. PMID: 28232325.", + "Implantable tissue-engineered blood vessels from human induced pluripotent stem cells. Gui L, Dash BC, Luo J, Qin L, Zhao L, Yamamoto K, Hashimoto T, Wu H, Dardik A, Tellides G, Niklason LE, Qyang Y. Biomaterials. 2016 Sep; 2016 Jun 14. PMID: 27336184.", + "Anisotropic engineered heart tissue made from laser-cut decellularized myocardium. Schwan J, Kwaczala AT, Ryan TJ, Bartulos O, Ren Y, Sewanan LR, Morris AH, Jacoby DL, Qyang Y, Campbell SG. Sci Rep. 2016 Aug 30; 2016 Aug 30. PMID: 27572147.", + "Tissue-Engineered Vascular Rings from Human iPSC-Derived Smooth Muscle Cells. Dash BC, Levi K, Schwan J, Luo J, Bartulos O, Wu H, Qiu C, Yi T, Ren Y, Campbell S, Rolle MW, Qyang Y. Stem Cell Reports. 2016 Jul 12. PMID: 27411102.", + "ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction. Bartulos O, Zhuang ZW, Huang Y, Mikush N, Suh C, Bregasi A, Wang L, Chang W, Krause DS, Young LH, Pober JS, Qyang Y. JCI Insight. 2016 Jul 7. PMID: 27525311.", + "Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis. Misra A, Sheikh AQ, Kumar A, Luo J, Zhang J, Hinton RB, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif DM. J Exp Med. 2016 Mar 7; 2016 Feb 8. PMID: 26858344.", + "Efficient gene disruption in cultured primary human endothelial cells by CRISPR/Cas9. Abrahimi P, Chang WG, Kluger MS, Qyang Y, Tellides G, Saltzman WM, Pober JS. Circ Res. 2015 Jul 3; 2015 May 4. PMID: 25940550.", + "Induced pluripotent stem cell-derived vascular smooth muscle cells: methods and application. Dash BC, Jiang Z, Suh C, Qyang Y. Biochem J. 2015 Jan 15. PMID: 25559088.", + "Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor. Sivarapatna A, Ghaedi M, Le AV, Mendez JJ, Qyang Y, Niklason LE. Biomaterials. 2015; 2015 Mar 24. PMID: 25890758.", + "Functional cardiomyocytes derived from Isl1 cardiac progenitors via Bmp4 stimulation. Cagavi E, Bartulos O, Suh CY, Sun B, Yue Z, Jiang Z, Yue L, Qyang Y. PLoS One. 2014; 2014 Dec 18. PMID: 25522363.", + "Advancements in Induced Pluripotent Stem Cell Technology for Cardiac Regenerative Medicine. Suh CY, Wang Z, Bártulos O, Qyang Y. J Cardiovasc Pharmacol Ther. 2014 Jul; 2014 Mar 19. PMID: 24651517.", + "Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos. Dunworth WP, Cardona-Costa J, Bozkulak EC, Kim JD, Meadows S, Fischer JC, Wang Y, Cleaver O, Qyang Y, Ober EA, Jin SW. Circ Res. 2014 Jan 3; 2013 Oct 11. PMID: 24122719.", + "Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency. Li W, Li Q, Qin L, Ali R, Qyang Y, Tassabehji M, Pober BR, Sessa WC, Giordano FJ, Tellides G. Arterioscler Thromb Vasc Biol. 2013 May; 2013 Mar 14. PMID: 23493289.", + "Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells. Ge X, Ren Y, Bartulos O, Lee MY, Yue Z, Kim KY, Li W, Amos PJ, Bozkulak EC, Iyer A, Zheng W, Zhao H, Martin KA, Kotton DN, Tellides G, Park IH, Yue L, Qyang Y. Circulation. 2012 Oct 2; 2012 Aug 22. PMID: 22914687.", + "Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2. Kim JD, Kang H, Larrivée B, Lee MY, Mettlen M, Schmid SL, Roman BL, Qyang Y, Eichmann A, Jin SW. Dev Cell. 2012 Aug 14. PMID: 22898784.", + "Regenerating functional heart tissue for myocardial repair. Alcon A, Cagavi Bozkulak E, Qyang Y. Cell Mol Life Sci. 2012 Aug; 2012 Mar 3. PMID: 22388688.", + "Evaluation of the use of an induced puripotent stem cell sheet for the construction of tissue-engineered vascular grafts. Hibino N, Duncan DR, Nalbandian A, Yi T, Qyang Y, Shinoka T, Breuer CK. J Thorac Cardiovasc Surg. 2012 Mar; 2012 Jan 12. PMID: 22244569.", + "Derivation of functional ventricular cardiomyocytes using endogenous promoter sequence from murine embryonic stem cells. Lee MY, Sun B, Schliffke S, Yue Z, Ye M, Paavola J, Bozkulak EC, Amos PJ, Ren Y, Ju R, Jung YW, Ge X, Yue L, Ehrlich BE, Qyang Y. Stem Cell Res. 2012 Jan; 2011 Aug 22. PMID: 22099020.", + "Methods of cell purification: a critical juncture for laboratory research and translational science. Amos PJ, Cagavi Bozkulak E, Qyang Y. Cells Tissues Organs. 2012; 2011 Oct 12. PMID: 21996576.", + "High density cultures of embryoid bodies enhanced cardiac differentiation of murine embryonic stem cells. Lee MY, Cagavi Bozkulak E, Schliffke S, Amos PJ, Ren Y, Ge X, Ehrlich BE, Qyang Y. Biochem Biophys Res Commun. 2011 Dec 9; 2011 Nov 6. PMID: 22079290.", + "Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells. Ren Y, Lee MY, Schliffke S, Paavola J, Amos PJ, Ge X, Ye M, Zhu S, Senyei G, Lum L, Ehrlich BE, Qyang Y. J Mol Cell Cardiol. 2011 Sep; 2011 May 4. PMID: 21569778.", + "Regeneration of a heart cell. Qyang Y, Senyei G. Yale J Biol Med. 2009 Sep. PMID: 19774125.", + "The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L, Granger A, Moretti A, Caron L, Wu X, Clarke J, Taketo MM, Laugwitz KL, Moon RT, Gruber P, Evans SM, Ding S, Chien KR. Cell Stem Cell. 2007 Aug 16; 2007 Jun 14. PMID: 18371348.", + "Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, Qyang Y, Bu L, Sasaki M, Martin-Puig S, Sun Y, Evans SM, Laugwitz KL, Chien KR. Cell. 2006 Dec 15; 2006 Nov 22. PMID: 17123592.", + "Isl1Cre reveals a common Bmp pathway in heart and limb development. Yang L, Cai CL, Lin L, Qyang Y, Chung C, Monteiro RM, Mummery CL, Fishman GI, Cogen A, Evans S. Development. 2006 Apr. PMID: 16556916.", + "T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Cai CL, Zhou W, Yang L, Bu L, Qyang Y, Zhang X, Li X, Rosenfeld MG, Chen J, Evans S. Development. 2005 May; 2005 Apr 20. PMID: 15843407.", + "Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage. Qyang Y, Chambers SM, Wang P, Xia X, Chen X, Goodell MA, Zheng H. Biochemistry. 2004 May 11. PMID: 15122901.", + "The novel Rho GTPase-activating protein family protein, Rga8, provides a potential link between Cdc42/p21-activated kinase and Rho signaling pathways in the fission yeast, Schizosaccharomyces pombe. Yang P, Qyang Y, Bartholomeusz G, Zhou X, Marcus S. J Biol Chem. 2003 Dec 5; 2003 Sep 23. PMID: 14506270.", + "The p21-activated kinase, Shk1, is required for proper regulation of microtubule dynamics in the fission yeast, Schizosaccharomyces pombe. Qyang Y, Yang P, Du H, Lai H, Kim H, Marcus S. Mol Microbiol. 2002 Apr. PMID: 11972773.", + "300 George Street New Haven, CT 06511", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Rakic Lab", + "lab_url": "https://medicine.yale.edu/lab/rakic/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/rakic/publications", + "publications": null + }, + { + "lab_name": "Ranganathan Research Lab", + "lab_url": "https://medicine.yale.edu/lab/ranganathan/", + "research_bio": "INFORMATION FOR Our lab is focused on the intersection of psychiatry, neuroscience, and substance use to advance knowledge of the underlying pathophysiology of psychiatric disorders, including schizophrenia and depression, and to develop novel biomarkers and treatments. We use a multidimensional approach considering the biological, psychological, and environmental factors that contribute to these conditions. We particularly investigate the impact of cannabis and cannabinoids on mental health, factors that influence the negative effects, as well as potential therapeutic benefits in the context of psychiatric disorders. We work to identify innovative biomarkers, therapeutic targets, and potential treatments by integrating laboratory, clinical and community-based research and through collaborations with clinicians, neuroscientists, and mental health professionals. We seek to bridge the gap between scientific breakthroughs and their practical applications. Our ultimate goal is to enhance the quality of life for those affected by these disorders and to deepen our understanding of both the complexities of mental health and the role of cannabis in mental health treatment. Please utilize the resources listed below: Copy Link Ranganathan Research Lab, VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT, 06516", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Rangaraju Lab", + "lab_url": "https://medicine.yale.edu/lab/rangaraju/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Regan Lab", + "lab_url": "https://medicine.yale.edu/lab/regan/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Reid Lab for Innovation in Population Health", + "lab_url": "https://medicine.yale.edu/lab/reid/", + "research_bio": "INFORMATION FOR The Reid Lab for Innovation in Population Health is dedicated to improving the health of patients, communities and populations locally and globally. We are an international team of clinicians and researchers focused on addressing inequities in health, with a particular interest in palliative and emergency care. Our research is centered on describing, evaluating and implementing upstream strategies to decrease inequities in health. Through collaborations with global partners and multidisciplinary, multicultural teams, we co-create and implement complex interventions in austere and resource-constrained environments that seek to improve access to and quality of care while reducing health inequities.", + "publications_page": "https://medicine.yale.edu/lab/reid/publications/", + "publications": [ + "Yale School of Medicine /", + "Emergency Medicine /", + "Lab Members", + "Research & Projects", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Lab Members", + "Research & Projects", + "Publications", + "", + "", + "", + "", + "", + "", + "Factors affecting initiation of palliative care in a Ugandan Emergency Department. Nalugya LG, Harborne D, Reid E. Afr J Emerg Med. 2021 Dec; 2021 Oct 28. PMID: 34765429.", + "Leadership communication, stress, and burnout among frontline emergency department staff amid the COVID-19 pandemic: A mixed methods approach. Sangal RB, Bray A, Reid E, Ulrich A, Liebhardt B, Venkatesh AK, King M. Healthc (Amst). 2021 Dec; 2021 Aug 13. PMID: 34411923.", + "Effectiveness and Reach of the Primary Palliative Care for Emergency Medicine (PRIM-ER) Pilot Study: a Qualitative Analysis. Chung FR, Turecamo S, Cuthel AM, Grudzen CR. J Gen Intern Med. 2021 Feb; 2020 Oct 27. PMID: 33111240.", + "Rationale and study design: A randomized controlled trial of early palliative care in newly diagnosed cancer patients in Addis Ababa, Ethiopia. Reid E, Abathun E, Diribi J, Mamo Y, Hall P, Fallon M, Wondemagegnhu T, Grant L. Contemp Clin Trials Commun. 2020 Jun; 2020 Apr 6. PMID: 32309673.", + "Global Emergency Medicine: A Review of the Literature from 2018. Trehan I, Osei-Ampofo M, Balhara KS, Hexom BJ, Kivlehan SM, Modi P, Pousson AY, Selvam A, Quao NSA, Cho DK, Becker TK, Levine AC. Acad Emerg Med. 2019 Oct; 2019 Aug 22. PMID: 31313411.", + "Is palliative care cost-effective in low-income and middle-income countries? A mixed-methods systematic review. Reid EA, Kovalerchik O, Jubanyik K, Brown S, Hersey D, Grant L. BMJ Support Palliat Care. 2019 Jun; 2018 Oct 1. PMID: 30274970.", + "Caring for Life-Limiting Illness in Ethiopia: A Mixed-Methods Assessment of Outpatient Palliative Care Needs. Reid EA, Gudina EK, Ayers N, Tigineh W, Azmera YM. J Palliat Med. 2018 May; 2018 Feb 9. PMID: 29425055.", + "What is the value of palliative care provision in low-resource settings? Anderson RE, Grant L. BMJ Glob Health. 2017; 2017 Feb 14. PMID: 28588999.", + "Global Emergency Medicine: A Review of the Literature From 2015. Becker TK, Hansoti B, Bartels S, Bisanzo M, Jacquet GA, Lunney K, Marsh R, Osei-Ampofo M, Trehan I, Lam C, Levine AC. Acad Emerg Med. 2016 Oct; 2016 Sep 20. PMID: 27146277.", + "A Rare but Lethal Cause of Chest Pain. Anderson RE, Wilcox S, Miller ES. J Emerg Med. 2015 Nov; 2015 Aug 15. PMID: 26281817.", + "Global emergency medicine: a review of the literature from 2014. Becker TK, Bartels S, Hansoti B, Jacquet GA, Lunney K, Marsh R, Osei-Ampofo M, Lam C, Levine AC. Acad Emerg Med. 2015 Aug; 2015 Jul 29. PMID: 26223901.", + "Defining the anesthesia gap for reproductive health procedures in resource-limited settings. Anderson RE, Ahn R, Nelson BD, Chavez J, de Redon E, Burke T. Int J Gynaecol Obstet. 2014 Dec; 2014 Aug 13. PMID: 25179170.", + "Emergency and urgent care capacity in a resource-limited setting: an assessment of health facilities in western Kenya. Burke TF, Hines R, Ahn R, Walters M, Young D, Anderson RE, Tom SM, Clark R, Obita W, Nelson BD. BMJ Open. 2014 Sep 26; 2014 Sep 26. PMID: 25260371.", + "Bright-blood T(2)-weighted MRI has high diagnostic accuracy for myocardial hemorrhage in myocardial infarction: a preclinical validation study in swine. Payne AR, Berry C, Kellman P, Anderson R, Hsu LY, Chen MY, McPhaden AR, Watkins S, Schenke W, Wright V, Lederman RJ, Aletras AH, Arai AE. Circ Cardiovasc Imaging. 2011 Nov; 2011 Sep 19. PMID: 21930836.", + "High-risk myocardial infarction in the young: the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial. Anderson RE, Pfeffer MA, Thune JJ, McMurray JJ, Califf RM, Velazquez E, White HD, Rouleau JL, Skali H, Maggioni A, Solomon SD. Am Heart J. 2008 Apr; 2008 Jan 31. PMID: 18371480.", + "Seamco Building 464 Congress Avenue New Haven, CT 06510", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Reinisch Laboratory", + "lab_url": "https://medicine.yale.edu/lab/reinisch/", + "research_bio": "INFORMATION FOR Copy Link A defining feature of cells are membrane bilayers that separate them from their environment and, in eukaryotic cells, delineate intracellular organelles with specialized functions. For cells to live and replicate, they must be able to maintain and expand these membranes. In eukaryotes, the lipid building blocks of membranes are made mostly in the endoplasmic reticulum (ER) and then transported to other organelles from there. While the role of vesicle trafficking for lipid transfer between organelles has long been known, we have only in the last decade begun to appreciate the importance of non-vesicular protein-mediated lipid transfer at so-called membrane contact sites, where two organelles are closely apposed. Indeed, the ER, the main site of lipid synthesis, contacts every other cellular organelle at such sites. The main focus of the laboratory is to identify and characterize the protein residents of contact sites in order to better elucidate the still largely unknown lipid transfer processes that occur there, their molecular basis, and their role in physiology. Contact site residents include lipid “shuttles”, proteins that equilibrate lipids between organelles, typically one lipid at a time, in order to fine-tune the lipid compositions of apposed contact site membranes. In addition, our group was central to the discovery of elongated lipid transfer proteins in the VPS13 family that span between organelles and serve as bridges, with long hydrophobic grooves that solubilize lipid fatty acid moieties, allowing for bulk lipid flow across the aqueous space between membranes. Our work suggests that these lipid transfer bridges work in partnership with integral membrane proteins, such as scramblases, to function in membrane expansion and organelle biogenesis, for example in the de novo formation of the autophagosome or the yeast prospore membrane. The role of protein-mediated lipid transfer in organelle biogenesis was unanticipated and previously thought to involve exclusively the fusion of hundreds of vesicles, as vesicles were until recently the only known mechanism for bulk lipid movement. We are continuing our systematic characterization of contact site proteins and their physiological roles; emphasis going forward is to dissect the mechanisms by which bridge-like lipid transporters collaborate with integral membrane proteins, including scramblases, to transfer lipids directionally from their site of synthesis to other organelles for membrane maintenance or de novo organelle formation. *Denotes co-first authors; † denotes co-corresponding authors. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/reinisch/publications/", + "publications": [ + "Yale School of Medicine /", + "Cell Biology /", + "Publications", + "People", + "Our Events", + "Contact", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Publications", + "People", + "Our Events", + "Contact", + "", + "", + "", + "", + "", + "", + "1 Li D, 1 Rocha-Roa C, Schilling MA, * Reinisch KM, *Vanni S. Lipid scrambling is a general feature of protein insertases. Proc Natl Acad Sci U S A. 2024; 121 (17): e2319476121. doi: 10.1073/pnas.2319476121. PMID38621120.", + "Wan N, Hong Z, Parson MAH, Korfhage JL, Burke JE, Melia TJ, and Reinisch KM. Spartin-mediated lipid transfer facilitates lipid droplet turnover. Proc Natl Acad Sci U S A. 2024; 121(3): e2314093121. doi: 10.1073/pnas.2314093121. PMID38190532.", + "Hong Z, Adlakha J, Wan N, Guinn E, Giska F, Gupta K, Melia TJ, Reinisch KM. Mitoguardin-2-mediated lipid transfer preserves mitochondrial morphology and lipid droplet formation. J Cell Biol. 2022; 221(12):e202207022. doi: 10.1083/jcb.202207022. PMID36282247.", + "1 Hanna MG, 1 Suen PH, Wu Y, *Reinisch KM, *De Camilli P. SHIP164 is a chorein motif lipid transfer protein that controls endosome-Golgi membrane traffic. J Cell Biol. 2022 Jun 6;221(6):e202111018. doi: 10.1083/jcb.202111018. PMID35499567.", + "1 Adlakha J, 1 Hong Z, Li P, Reinisch KM. Structural and biochemical insights into lipid transport by VPS13 proteins. J Cell Biol. 2022; 221(5):e202202030. doi: 10.1083/jcb.202202030. PMID35357422.", + "*Melia TJ, *Reinisch KM. A possible role for VPS13-family proteins in bulk lipid transfer, membrane expansion and organelle biogenesis. J Cell Sci. 2022;135(5):jcs259357. doi: 10.1242/jcs.259357. PMID35267021.", + "*Reinisch KM, *Melia TJ . \"VTT\"-domain proteins VMP1 and TMEM41B function in lipid homeostasis globally and locally as ER scramblases. Contact 2021; 4:10.1177/25152564211024494. doi: 10.1177/25152564211024494. PMID34447902.", + "1 Ghanbarpour A, 1 Valverde DP, *Melia TJ, *Reinisch KM. A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis. Proc Natl Acad Sci U S A. 2021; 118(16):e2101562118. doi: 10.1073/pnas.2101562118. PMID33850023.", + "*Leonzino M, *Reinisch KM, *De Camilli P. Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport. Biochim Biophys Acta Mol Cell Biol Lipids. 2021;1866(10):159003. doi: 10.1016/j.bbalip.2021.159003. PMID34216812.", + "*Reinisch KM, *Prinz WA. Mechanisms of nonvesicular lipid transport. J Cell Biol. 2021;220(3):e202012058. doi: 10.1083/jcb.202012058. PMID33605998.", + "1 Lees JA, 1Li P, Kumar N, Weisman LS, Reinisch KM. Insights into Lysosomal PI(3,5)P2 Homeostasis from a Structural-Biochemical Analysis of the PIKfyve Lipid Kinase Complex. Mol Cell. 2020; 80(4):736-743.e4. doi: 10.1016/j.molcel.2020.10.003. PMID33098764.", + "*Lees JA, *Reinisch KM. Inter-organelle lipid transfer: a channel model for Vps13 and chorein-N motif proteins. Curr Opin Cell Biol. 2020; 65:66-71. doi: 10.1016/j.ceb.2020.02.008. PMID32213462; PMC7885529.", + "Li P., Lees JA., Lusk CP., Reinisch KM., Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes. J Cell Biol . 2020 May 4; jcb. 202001161.", + "Scorrano L, De Matteis MA, Emr S, Giordano F, Hajnóczky G, Kornmann B, Lackner LL, Levine TP, Pellegrini L, Reinisch K, Rizzuto R, Simmen T, Stenmark H, Ungermann C, Schuldiner M. Coming together to define membrane contact sites. Nat Commun. 2019;10(1):1287. doi: 10.1038/s41467-019-09253-3. PMID30894536.", + "Valverde DP. 1 , Yu S. 1 , Boggavarapu V., Kumar N., Lees JA., Walz* T., Reinisch * KM., Melia* TJ. ATG2 transports lipids to promote autophagosome biogenesis. J Cell Biol . 2019 Apr 5;jcb. 201811139. 1 co-first authors, *co-corresponding authors.", + "Kumar N. 1 , Leonzino M. 1 , Hancock-Cerutti W., Horenkamp FA, Li P, Wheeler H, Reinisch * KM. VPS13A and VPS13C are lipid transfer proteins differentially localized at ER contact sites. J Cell Biol . 2018 Aug 9;jcb. 201807019. 1 co-first authors, *co-corresponding authors.", + "Horenkamp FA. 1 , Valverde DP. 1 , Nunnari J, Reinisch * KM. Molecular basis for sterol transport by StART-like lipid transfer domains. EMBO J . 2018 Mar 15;37(6). 1 co-first authors, *co-corresponding authors.", + "Lees JA. 1 , Zhang Y. 1 , Oh MS., Schauder CM., Yu X., Baskin JM., Dobbs K., Notarangelo LD., De Camilli* P., Walz* T., Reinisch * KM.Architecture of the human PI4KIIIa lipid kinase complex. PNAS 2017 Dec 26;114(52):13720-25. 1 co-first authors, *co-corresponding authors.", + "Lees JA. 1 , Messa M. 1 , Sun EW., Wheeler H., Torta F., Wenk MR., De Camilli* P., Reinisch * KM. Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion. Science . 2017 Feb 17;355(6326). 1 co-first authors, *co-corresponding authors.", + "Baskin JM. 1 , Wu X. 1 , Christiano R., Oh MS., Schauder CM., Gazzerro E., Messa M., Baldassari S., Assereto S., Biancheri R., Zara F., Minetti C., Raimondi A., Simons M., Walther TC., Reinisch * KM., De Camilli* P. The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Nature Cell Biology 2016, Jan;18(1):132-8. 1 co-first authors, *co-corresponding authors.", + "Horenkamp FA., Kauffman KJ., Kohler LJ., Sherwood RK., Krueger KP., Shteyn V., Roy CR., Melia* TJ., Reinisch * K.M. The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs. Dev Cell 2015, 14;34(5) :569-76. *co-corresponding authors.", + "Krishnakumar* SS., Li F., Coleman J., Schauder CM., Kümmel D., Pincet F., Rothman JE., Reinisch * K.M. Re-visiting the trans insertion model for complexin clamping. Elife 2015 Apr 2;4. *co-corresponding authors.", + "Cai Y., Deng Y., Horenkamp F., Reinisch * K.M., Burd* C.G. Sac1-Vps74 structure reveals a mechanism to terminate phosphoinositide signaling in the Golgi apparatus. JCB 2014, 206 :485-91. *co-corresponding authors.", + "Schauder C.M., Wu X., Saheki Y., Narayanaswamy P., Torta F., Wenk M.R., De Camilli* P., Reinisch * K.M. Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer. Nature 2014, 510 :552-55. *co-corresponding authors.", + "Langemeyer L., Nunes Bastos R., Cai Y., Itzen A., Reinisch K.M., Barr F.A. Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation. e Life 2014, 3 :e01623", + "Horenkamp F.A., Mukherjee S., Alix E., Schauder C.M., Hubber A.M., Roy C.R., Reinisch K.M. Legionella pneumophila subversion of host vesicular transport by SidC effector proteins. Traffic 2014, 15 :488-99.", + "Wu X., Chi R.J., Baskin J.M., Lucast L., Burd C.G., De Camilli P., Reinisch K.M. Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex. Dev. Cell 2014, 28 :19-29.", + "Tan D. 1 , Cai Y 1 , Wang J., Zhang J., Menon S., Chou H.T., Ferro-Novick S.*, Reinisch K.M.*, Walz T*. The EM structure of the TRAPPIII complex leads to the identification of a requirement for COPII vesicles on the macroautophagy pathway. PNAS 2013, 110 :19432-7. 1 co-first authors, *co-corresponding authors.", + "Wu, X., Bradley, M.J., Kümmel, D., Cai, Y., De La Cruz, E.M., Barr, F.A., Reinisch , K.M. Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate. PNAS 2011, 108 :18672-18677.", + "Kümmel, D., Krishnakumar, S.S., Radoff, D.T., Li, F., Giraudo, C.G., Pincet, F., Rothman*, J.E., Reinisch *, K.M. Complexin cross-links pre-fusion SNAREs into a zig-zag assembly. NSMB 2011, 18 :927-933. *co-corresponding authors.", + "Hughson, F.M. & Reinisch , K.M. Structure and mechanism in membrane trafficking. Curr. Opin. Cell Biol. 2010, 22 :454-460.", + "Hamill, S., *Wolin, S.L., and * Reinisch , K.M. Structure and function of the polymerase core of TRAMP, a RNA surveillance complex. PNAS 2010, 107 : 15045-15050. *co-corresponding authors.", + "Vasan, N., Hutagalung, A., Novick, P., and Reinisch , K.M. Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of Golgi-associated retrograde protein (GARP) complex to a family of tethering complexes. PNAS 2010, 107 : 14176-14181.", + "Sclafani, A., Chen, S., Rivera-Molina, F., Reinisch , K., Novick, P., Ferro-Novick, S. Establishing a role for the GTPase Ypt1 at the late Golgi. Traffic 2010, 11 : 520-532.", + "Barrowman, J., Bhandari, D., Reinisch , K. & Ferro-Novick, S. TRAPP complexes in membrane traffic: convergence through a common Rab. Nat. Rev. Cell Biol. 2010, 11: 759-763.", + "Chin, H.F., Cai, Y., Menon, S., Ferro-Novick, S., Reinisch , K.M., De La Cruz, E.M. Kinetic analysis of TRAPP, a multimeric Ypt1p exchange factor. JMB 2009, 389 : 275-288.", + "Dong, G., Wearsch, P.A., Peaper, D.R., Cresswell*, P., and Reinisch *, K.M. Insights into MHC class I peptide loading from the structure of the tapasin/ERp57 heterodimer. Immunity 2009, 30 : 21-32. *co-corresponding authors.", + "Cai, Y., Chin, H.F., Lazarova, D., Menon, S., Fu, C., Sclafani, A., Cai, H., Rodgers, D.W., De La Cruz, E.M., Ferro-Novick*, S. & Reinisch *, K.M. The structural basis for the activation of the Rab Ypt1p by the TRAPP membrane tethering complexes. Cell 2008, 133 :1202-1213. *co-corresponding authors.", + "Cai, H., Reinisch , K. & Ferro-Novick, S. Coats, tethers, Rabs, SNAREs work together to mediate the intracellular destination of a transport vesicle. Dev. Cell 2007, 12 : 671-682.", + "Cai, H., Yu, S., Menon, S., Cai, Y., Lazarova, D., Fu, C., Reinisch , K., Hay, J.C. & Ferro-Novick, S. TRAPPI tethers COPII vesicles by binding the coat subunit Sec23. Nature 2007, 445 : 941-944.", + "Dong, G., Medkova, M., Novick*, P. & Reinisch *, K.M. A catalytic coiled-coil: activation of the Rab GTPase Sec4p by Sec2p. Mol. Cell 2007, 25 :455-462. *co-corresponding authors.", + "Wolin, S.L. & Reinisch , K.M.Emerging themes in non-coding RNA quality control. Curr. Opin. Struct. Biol. 2007, 17 : 209-214.", + "Fuchs, G., Stein, A.J., Fu, C., Reinisch *, K.M. & Wolin*, S.L. Structural and biochemical basis for misfolded RNA recognition by the Ro autoantigen. Nat. Struct. Mol. Biol. 2006, 13 :1002-1009. *co-corresponding authors.", + "Wolin, S.L. & Reinisch, K.M. The Ro 60kDa autoantigen comes into focus: interpreting epitope mapping experiments on the basis of structure. Autoimmun . Rev. 2006, 5 : 367-372.", + "Dong, G., Hutagalung, A.H., Fu, C., Novick*, P. & Reinisch *, K.M. The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif. Nat. Struct. Mol. Biol. 2005, 12 : 1094-1100. *co-corresponding authors", + "Stein, A.J., Fuchs, G., Fu, C., Wolin, S.L. & Reinisch , K.M. Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity. Cell 2005, 121 :529-539.", + "Dong, G., Chakshusmathi, G, Wolin, S.L. & Reinisch , K.M. Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch. EMBO J . 2004, 23 :1000-1007.", + "Reinisch , K.M. The dsRNA viridae and their catalytic capsids. Nat. Struct. Biol. 2002, 9 : 714-716.", + "Reinisch , K.M., Nibert, M.L. & Harrison, S.C. Structure of the reovirus core at 3.6 Å resolution. Nature 2000, 404 : 960-967.", + "Luongo, C.L., Reinisch , K.M., Harrison, S.C. & Nibert, M.L. Identification of the guanylyltransferase region and active site in reovirus mRNA capping protein lambda2. J. Biol. Chem. 2000, 275 : 2804-2810.", + "Reinisch , K.M., Chen, L., Verdine, G.L. & Lipscomb, W.N. The crystal structure of HaeIII methyltransferase covalently complexed to DNA: an extrahelical cytosine and rearranged base pairing. Cell 1995, 82 : 143-153.", + "Reinisch , K.M., Chen, L., Verdine, G.L. & Lipscomb, W.N. Crystallization and preliminary crystallographic analysis of a DNA (cytosine-5)-methyltransferase from Haemophilus aegyptius bound covalently to DNA. J. Mol. Biol. 1994, 238 : 626-629.", + "Sterling Hall of Medicine 333 Cedar Street New Haven, CT 06520", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Reinke Lab", + "lab_url": "https://medicine.yale.edu/lab/reinke/", + "research_bio": "INFORMATION FOR The fate of any species depends on the quality of its germ cells. These highly specialized cells are the only ones capable of contributing genetic information to the next generation; every other cell in the body exists no longer than a single lifetime. Because germ cells are the repository of the future, the genome of these cells must be protected from mutations and other forms of damage. However, germ cells are not simply passive carriers of genetic information, but must also undergo complex events such as meiosis, gametogenesis, and fertilization. To correctly implement these programs while preserving genome integrity, germ cells have a unique arsenal of tricks to control genes during germ cell development and function. The nematode C. elegans is an ideal model system for exploring gene regulation in germ cells because it provides powerful genetics, cell biology, and genomics approaches to address outstanding questions in the field. Currently, we are investigating multiple transcriptional and epigenetic mechanisms that determine germ cell fate and function. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/reinke/publications/", + "publications": null + }, + { + "lab_name": "Resilience, Empowerment, & Addiction Leadership Lab", + "lab_url": "https://medicine.yale.edu/lab/haeny/", + "research_bio": "INFORMATION FOR Welcome to the Resilience, Empowerment, & Addiction Leadership (REAL) lab. The REAL lab focuses on developing leaders passionate about building resilience through empowerment to promote improvements in addiction and other health outcomes among priority populations. We believe collaboration is key, so we foster an environment where various perspectives come together to spark creativity and drive discovery. Our research is attentive to constructs like craving, racial stress, identity, internalized oppression, and social determinants of health. We address pressing issues in addiction research using sophisticated methods including personalized imagery racial stress script procedures, data harmonization techniques, and psychometric testing including evaluating measurement invariance. Past and ongoing research projects span a variety of topics that include conceptualizing and assessing craving for alcohol, stimulants, nicotine, opioids, and cannabis; attending to racial stress and trauma in treatment; evaluating alcohol and drug treatment utilization, barriers, and outcomes; and understanding the process of self-change. We leverage both quantitative and qualitative methodologies to address our research questions.Through partnerships with community members with lived experience and other key stakeholders, we aim to translate our findings into real-world solutions that make a difference. Together, we will shape the future and create a positive impact through research. Copy Link For any inquiries, please contact us, Monday to Friday, 8:00 am - 5:00 pm EST", + "publications_page": "https://medicine.yale.edu/lab/haeny/publications/", + "publications": null + }, + { + "lab_name": "Rimm Lab", + "lab_url": "https://medicine.yale.edu/lab/rimm/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Rinehart Lab", + "lab_url": "https://medicine.yale.edu/lab/rinehart/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Rizzolo Lab", + "lab_url": "https://medicine.yale.edu/lab/rizzolo/", + "research_bio": "INFORMATION FOR Retinal degenerations are major causes of visual impairment, especially in aging and diabetic populations. My laboratory uses human embryonic and induced pluripotent stem cells to study and treat retinal disease. The retinal pigment epithelium (RPE) separates photoreceptors from their blood supply in the choroid, and therefore, is responsible for their health. We demonstrated how RPE functions are regulated by interactions with the retina and the choroid. Our goal is to bioengineer a three-dimensional culture model that includes RPE and retinal neurons derived from human stem cells. The Rizzolo Lab conducts research in both the biomedical field of with its study of retinal pigment epithelium (RPE) as well as educational research with its design of a \"Clinically-Engaged Anatomy\" curriculum. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/rizzolo/publications/", + "publications": [ + "Yale School of Medicine /", + "Surgery /", + "Research Biomedical Research Educational Research", + "Biomedical Research", + "Educational Research", + "Publications", + "Lab Members", + "Contact", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Publications", + "Lab Members", + "Contact", + "", + "", + "", + "", + "", + "", + "Tibial plateau fractures are associated with ligamentous and meniscal injuries. Preoperative evaluation of magnetic resonance imaging influences surgical treatment. Risitano S, Giustra F, Bosco F, Rea A, Cacciola G, Rizzolo R, Sabatini L, Capella M, Massè A. Eur J Trauma Emerg Surg. 2024 Oct; 2024 Jun 26. PMID: 38926170.", + "Retinal Cell Transplantation, Biomaterials, and In Vitro Models for Developing Next-generation Therapies of Age-related Macular Degeneration. Rizzolo LJ, Nasonkin IO, Adelman RA. Stem Cells Transl Med. 2022 Mar 31. PMID: 35356975.", + "Analysis of Population Representation Among Willed Whole-Body Donors to Facilitate the Construction of a Body Donation Program in China: From the Perspective of Medical Students and Anatomists. Zhang H, Chen K, Wang N, Zhang D, Zhang Q, Tang K, Wan M, Gong C, Hong X, Qiu W, Rizzolo LJ, Ma C. Omega (Westport). 2022 Mar; 2020 Jun 9. PMID: 32515268.", + "Altered transcriptome and disease-related phenotype emerge only after fibroblasts harvested from patients with age-related macular degeneration are differentiated into retinal pigment epithelium. Cai H, Gong J, Noggle S, Paull D, Rizzolo LJ, Del Priore LV, Fields MA. Exp Eye Res. 2021 Jun; 2021 Apr 22. PMID: 33895162.", + "Knockdown of Claudin-19 in the Retinal Pigment Epithelium Is Accompanied by Slowed Phagocytosis and Increased Expression of SQSTM1. Liu F, Peng S, Adelman RA, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2021 Feb 1. PMID: 33591357.", + "Partially Differentiated Neuroretinal Cells Promote Maturation of the Retinal Pigment Epithelium. Singh D, Chen X, Xia T, Ghiassi-Nejad M, Tainsh L, Adelman RA, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2020 Nov 2. PMID: 33151282.", + "Unstimulated, Serum-free Cultures of Retinal Pigment Epithelium Excrete Large Mounds of Drusen-like Deposits. Chen X, Singh D, Adelman RA, Rizzolo LJ. Curr Eye Res. 2020 Nov; 2020 Mar 30. PMID: 32202447.", + "Claudins regulate gene and protein expression of the retinal pigment epithelium independent of their association with tight junctions. Liu F, Xu T, Peng S, Adelman RA, Rizzolo LJ. Exp Eye Res. 2020 Sep; 2020 Jul 23. PMID: 32712183.", + "Interactions of the choroid, Bruch's membrane, retinal pigment epithelium, and neurosensory retina collaborate to form the outer blood-retinal-barrier. Fields MA, Del Priore LV, Adelman RA, Rizzolo LJ. Prog Retin Eye Res. 2020 May; 2019 Nov 5. PMID: 31704339.", + "Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions. Gong J, Cai H, Noggle S, Paull D, Rizzolo LJ, Del Priore LV, Fields MA. Stem Cells Transl Med. 2020 Mar; 2019 Dec 16. PMID: 31840941.", + "Disease-associated mutations of claudin-19 disrupt retinal neurogenesis and visual function. Wang SB, Xu T, Peng S, Singh D, Ghiassi-Nejad M, Adelman RA, Rizzolo LJ. Commun Biol. 2019; 2019 Mar 25. PMID: 30937396.", + "A biodegradable scaffold enhances differentiation of embryonic stem cells into a thick sheet of retinal cells. Singh D, Wang SB, Xia T, Tainsh L, Ghiassi-Nejad M, Xu T, Peng S, Adelman RA, Rizzolo LJ. Biomaterials. 2018 Feb; 2017 Oct 31. PMID: 29128844.", + "Neferine, is not inducer but blocker for macroautophagic flux targeting on lysosome malfunction. Xu T, Singh D, Liu J, Li H, Peng S, Rizzolo LJ, Wang SB. Biochem Biophys Res Commun. 2018 Jan 1; 2017 Nov 29. PMID: 29197576.", + "Effects of diabetic retinopathy on the barrier functions of the retinal pigment epithelium. Xia T, Rizzolo LJ. Vision Res. 2017 Oct; 2017 Mar 30. PMID: 28347688.", + "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression. Peng S, Wang SB, Singh D, Zhao PY, Davis K, Chen B, Adelman RA, Rizzolo LJ. Exp Eye Res. 2016 Oct; 2016 Sep 1. PMID: 27593915.", + "Human Adult Retinal Pigment Epithelial Stem Cell-Derived RPE Monolayers Exhibit Key Physiological Characteristics of Native Tissue. Blenkinsop TA, Saini JS, Maminishkis A, Bharti K, Wan Q, Banzon T, Lotfi M, Davis J, Singh D, Rizzolo LJ, Miller S, Temple S, Stern JH. Invest Ophthalmol Vis Sci. 2015 Nov. PMID: 26540654.", + "The student's dilemma, liver edition: incorporating the sonographer's language into clinical anatomy education. Hall MK, Mirjalili SA, Moore CL, Rizzolo LJ. Anat Sci Educ. 2015 May-Jun; 2015 Jan 8. PMID: 25573229.", + "TRP Channels Localize to Subdomains of the Apical Plasma Membrane in Human Fetal Retinal Pigment Epithelium. Zhao PY, Gan G, Peng S, Wang SB, Chen B, Adelman RA, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2015 Mar 3; 2015 Mar 3. PMID: 25736794.", + "Barrier properties of cultured retinal pigment epithelium. Rizzolo LJ. Exp Eye Res. 2014 Sep; 2014 Apr 14. PMID: 24731966.", + "Engineering a blood-retinal barrier with human embryonic stem cell-derived retinal pigment epithelium: transcriptome and functional analysis. Peng S, Gan G, Qiu C, Zhong M, An H, Adelman RA, Rizzolo LJ. Stem Cells Transl Med. 2013 Jul; 2013 Jun 3. PMID: 23734062.", + "Effects of proinflammatory cytokines on the claudin-19 rich tight junctions of human retinal pigment epithelium. Peng S, Gan G, Rao VS, Adelman RA, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2012 Jul 27; 2012 Jul 27. PMID: 22761260.", + "Differential expression of claudins in retinas during normal development and the angiogenesis of oxygen-induced retinopathy. Luo Y, Xiao W, Zhu X, Mao Y, Liu X, Chen X, Huang J, Tang S, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2011 Sep 29; 2011 Sep 29. PMID: 21862644.", + "Integration of tight junctions and claudins with the barrier functions of the retinal pigment epithelium. Rizzolo LJ, Peng S, Luo Y, Xiao W. Prog Retin Eye Res. 2011 Sep; 2011 Jun 17. PMID: 21704180.", + "Claudin-19 and the barrier properties of the human retinal pigment epithelium. Peng S, Rao VS, Adelman RA, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2011 Mar; 2011 Mar 14. PMID: 21071746.", + "Effectiveness of a shortened, clinically engaged anatomy course for physician assistant students. Rizzolo LJ, Rando WC, O'Brien MK, Garino A, Stewart WB. Anat Sci Educ. 2011 Mar-Apr; 2011 Feb 18. PMID: 21337718.", + "Minimal effects of VEGF and anti-VEGF drugs on the permeability or selectivity of RPE tight junctions. Peng S, Adelman RA, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2010 Jun; 2009 Dec 30. PMID: 20042644.", + "Design, implementation, and evaluation of an innovative anatomy course. Rizzolo LJ, Rando WC, O'Brien MK, Haims AH, Abrahams JJ, Stewart WB. Anat Sci Educ. 2010 May-Jun. PMID: 20496432.", + "The 2008 anatomy ceremony: essays. Elansary M, Goldberg B, Qian T, Rizzolo LJ. Yale J Biol Med. 2009 Mar. PMID: 19325944.", + "A novel rabbit model for studying RPE transplantation. Cong L, Sun D, Zhang Z, Jiao W, Rizzolo LJ, Peng S. Invest Ophthalmol Vis Sci. 2008 Sep; 2008 May 23. PMID: 18502985.", + "Anatomists debate the value of a teaching credential. Rizzolo LJ, Drake RL. Anat Sci Educ. 2008 Mar-Apr. PMID: 19177383.", + "Diffusible retinal secretions regulate the expression of tight junctions and other diverse functions of the retinal pigment epithelium. Sun R, Peng S, Chen X, Zhang H, Rizzolo LJ. Mol Vis. 2008; 2008 Dec 8. PMID: 19057659.", + "Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier. Rizzolo LJ, Chen X, Weitzman M, Sun R, Zhang H. Mol Vis. 2007 Jul 23; 2007 Jul 23. PMID: 17679949.", + "Development and role of tight junctions in the retinal pigment epithelium. Rizzolo LJ. Int Rev Cytol. 2007. PMID: 17338922.", + "Should we continue teaching anatomy by dissection when ...? Rizzolo LJ, Stewart WB. Anat Rec B New Anat. 2006 Nov. PMID: 17109419.", + "Expression of JAM-A, AF-6, PAR-3 and PAR-6 during the assembly and remodeling of RPE tight junctions. Luo Y, Fukuhara M, Weitzman M, Rizzolo LJ. Brain Res. 2006 Sep 19; 2006 Jul 21. PMID: 16859655.", + "Effects of culture conditions on heterogeneity and the apical junctional complex of the ARPE-19 cell line. Luo Y, Zhuo Y, Fukuhara M, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2006 Aug. PMID: 16877439.", + "Anatomical instruction and training for professionalism from the 19th to the 21st centuries. Warner JH, Rizzolo LJ. Clin Anat. 2006 Jul. PMID: 16617459.", + "Design principles for developing an efficient clinical anatomy course. Rizzolo LJ, Stewart WB, O'Brien M, Haims A, Rando W, Abrahams J, Dunne S, Wang S, Aden M. Med Teach. 2006 Mar. PMID: 16707295.", + "The apical and basal environments of the retinal pigment epithelium regulate the maturation of tight junctions during development. Rahner C, Fukuhara M, Peng S, Kojima S, Rizzolo LJ. J Cell Sci. 2004 Jul 1. PMID: 15226402.", + "Apical and basal regulation of the permeability of the retinal pigment epithelium. Peng S, Rahner C, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2003 Feb. PMID: 12556417.", + "Human dissection: an approach to interweaving the traditional and humanistic goals of medical education. Rizzolo LJ. Anat Rec. 2002 Dec 15. PMID: 12467081.", + "Correlation of Web usage and exam performance in a human anatomy and development course. Rizzolo LJ, Aden M, Stewart WB. Clin Anat. 2002 Aug. PMID: 12203379.", + "Claudin 5 is transiently expressed during the development of the retinal pigment epithelium. Kojima S, Rahner C, Peng S, Rizzolo LJ. J Membr Biol. 2002 Mar 15. PMID: 11944085.", + "Defects in the MITF(mi/mi) apical surface are associated with a failure of outer segment elongation. Bumsted KM, Rizzolo LJ, Barnstable CJ. Exp Eye Res. 2001 Sep. PMID: 11520113.", + "Differential regulation of tight junction permeability during development of the retinal pigment epithelium. Ban Y, Rizzolo LJ. Am J Physiol Cell Physiol. 2000 Sep. PMID: 10942725.", + "Regulation of glucose transporters during development of the retinal pigment epithelium. Ban Y, Rizzolo LJ. Brain Res Dev Brain Res. 2000 May 11. PMID: 10837896.", + "Two secreted retinal factors regulate different stages of development of the outer blood-retinal barrier. Ban Y, Wilt SD, Rizzolo LJ. Brain Res Dev Brain Res. 2000 Feb 7. PMID: 10675776.", + "Polarization of the Na+, K(+)-ATPase in epithelia derived from the neuroepithelium. Rizzolo LJ. Int Rev Cytol. 1999. PMID: 9750268.", + "Protein-binding domains of the tight junction protein, ZO-2, are highly conserved between avian and mammalian species. Collins JR, Rizzolo LJ. Biochem Biophys Res Commun. 1998 Nov 27. PMID: 9837755.", + "A culture model of development reveals multiple properties of RPE tight junctions. Ban Y, Rizzolo LJ. Mol Vis. 1997 Dec 31; 1997 Dec 31. PMID: 9479009.", + "Remodeling of junctional complexes during the development of the outer blood-retinal barrier. Williams CD, Rizzolo LJ. Anat Rec. 1997 Nov. PMID: 9372172.", + "Polarity and the development of the outer blood-retinal barrier. Rizzolo LJ. Histol Histopathol. 1997 Oct. PMID: 9302567.", + "Differentiation and transdifferentiation of the retinal pigment epithelium. Zhao S, Rizzolo LJ, Barnstable CJ. Int Rev Cytol. 1997. PMID: 9066129.", + "The distribution of Na+,K(+)-ATPase and 5A11 antigen in apical microvilli of the retinal pigment epithelium is unrelated to alpha-spectrin. Rizzolo LJ, Zhou S. J Cell Sci. 1995 Nov. PMID: 8586673.", + "The neural retina maintains integrins in the apical membrane of the RPE early in development. Rizzolo LJ, Zhou S, Li ZQ. Invest Ophthalmol Vis Sci. 1994 Apr. PMID: 8163344.", + "Diffusible, retinal factors stimulate the barrier properties of junctional complexes in the retinal pigment epithelium. Rizzolo LJ, Li ZQ. J Cell Sci. 1993 Nov. PMID: 8308068.", + "Apical orientation of the microtubule organizing center and associated gamma-tubulin during the polarization of the retinal pigment epithelium in vivo. Rizzolo LJ, Joshi HC. Dev Biol. 1993 May. PMID: 8482407.", + "Basement membrane stimulates the polarized distribution of integrins but not the Na,K-ATPase in the retinal pigment epithelium. Rizzolo LJ. Cell Regul. 1991 Nov. PMID: 1667092.", + "The polarity of the retinal pigment epithelium is developmentally regulated. Rizzolo LJ, Heiges M. Exp Eye Res. 1991 Oct. PMID: 1657628.", + "The distribution of Na+,K(+)-ATPase in the retinal pigmented epithelium from chicken embryo is polarized in vivo but not in primary cell culture. Rizzolo LJ. Exp Eye Res. 1990 Oct. PMID: 2170160.", + "A growth hormone-vesicular stomatitis virus G hybrid protein is rapidly degraded in lysosomes following transport to the cell surface. Rizzolo LJ. Eur J Cell Biol. 1989 Jun. PMID: 2547615.", + "Post-translational protein modification in the endoplasmic reticulum. Demonstration of fatty acylase and deoxymannojirimycin-sensitive alpha-mannosidase activities. Rizzolo LJ, Kornfeld R. J Biol Chem. 1988 Jul 5. PMID: 2967826.", + "The influenza hemagglutinin insertion signal is not cleaved and does not halt translocation when presented to the endoplasmic reticulum membrane as part of a translocating polypeptide. Finidori J, Rizzolo L, Gonzalez A, Kreibich G, Adesnik M, Sabatini DD. J Cell Biol. 1987 Jun. PMID: 3294860.", + "Nonpolarized secretion of truncated forms of the influenza hemagglutinin and the vesicular stomatitus virus G protein from MDCK cells. Gonzalez A, Rizzolo L, Rindler M, Adesnik M, Sabatini DD, Gottlieb T. Proc Natl Acad Sci U S A. 1987 Jun. PMID: 3035552.", + "Secretion of endogenous and exogenous proteins from polarized MDCK cell monolayers. Gottlieb TA, Beaudry G, Rizzolo L, Colman A, Rindler M, Adesnik M, Sabatini DD. Proc Natl Acad Sci U S A. 1986 Apr. PMID: 3083413.", + "Sorting and endocytosis of viral glycoproteins in transfected polarized epithelial cells. Gottlieb TA, Gonzalez A, Rizzolo L, Rindler MJ, Adesnik M, Sabatini DD. J Cell Biol. 1986 Apr. PMID: 3007530.", + "Biosynthesis and intracellular sorting of growth hormone-viral envelope glycoprotein hybrids. Rizzolo LJ, Finidori J, Gonzalez A, Arpin M, Ivanov IE, Adesnik M, Sabatini DD. J Cell Biol. 1985 Oct. PMID: 2995406.", + "Kinetics and protein subunit interactions of Escherichia coli phosphatidylserine decarboxylase in detergent solution. Rizzolo LJ. Biochemistry. 1981 Feb 17. PMID: 7011377.", + "Behavior of fragmented calcium (II) adenosine triphosphatase from sarcoplasmic reticulum in detergent solution. Rizzolo LJ, Tanford C. Biochemistry. 1978 Sep 19. PMID: 152120.", + "Denaturation of the tryptic fragments of the calcium (II) adenosine triphosphatase from sarcoplasmic reticulum by guanidinium hydrochloride. Rizzolo LJ, Tanford C. Biochemistry. 1978 Sep 19. PMID: 152119.", + "Molecular weights and hydrophobicity of the polypeptide chain of sarcoplasmic reticulum calcium(II) adenosine triphosphatase and of its primary tryptic fragments. Rizzolo LJ, Maire M, Reynolds JA, Tanford C. Biochemistry. 1976 Aug 10. PMID: 133715.", + "Brady Memorial Laboratory 310 Cedar Street New Haven, CT 06520-8023 Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Rodeheffer Lab", + "lab_url": "https://medicine.yale.edu/lab/rodeheffer/", + "research_bio": "INFORMATION FOR The primary focus of the Rodeheffer laboratory is to elucidate the cellular and molecular mechanisms that control adipose tissue mass in both normal and disease states. Adipose tissue is primarily composed of lipid-filled adipocytes, which arise from adipocyte precursor cells during embryonic and postnatal development. In obesity, adipocyte precursor cells give rise to new adipocytes, contributing the the growth of white adipose tissue. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/rodeheffer/publications/", + "publications": [ + "Yale School of Medicine /", + "Yale Center for Molecular and Systems Metabolism (YMSM) /", + "Research", + "People", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "News", + "", + "", + "", + "", + "", + "", + "Jeffery E, Wing A, Holtrup B, Sebo Z, Kaplan J, Saavedra-Pena R, Church CD, Colman L, Berry R, Rodeheffer MS (2016). The adipose tissue microenvironment regulates depot-specific adipogenesis in obesity. Cell Metabolism, 24, 1-9.", + "Jeffery E, Church CD, Holtrup B, Colman L, Rodeheffer MS. (2015). Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity . Nature Cell Biol, 17, 376-386.", + "Jeffery E, Berry R, Church CD, Yu S, Shook BA, Horsley V, Rosen ED, and Rodeheffer MS (2014). Characterization of Cre recombinase models for the study of adipose tissue . Adipocyte 3 , 206-211.", + "Berry R, and Rodeheffer MS. (2013). Characterization of the adipocyte cellular lineage in vivo . Nat Cell Biol 15 , 302-308.", + "Birsoy K, Berry R, Wang T, Ceyhan O, Tavazoie S, Friedman JM, and Rodeheffer MS. (2011). Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis . Development 138 , 4709-4719.", + "Rodeheffer MS, Birsoy K, and Friedman JM. (2008). Identification of white adipocyte progenitor cells in vivo . Cell 135 , 240-249.", + "Berry R, Jeffery E, and Rodeheffer MS. (2014). Weighing in on adipocyte precursors . Cell Metab 19 , 8-20.", + "Berry R, Church CD, Gericke MT, Jeffery E, Colman L, and Rodeheffer MS. (2014). Imaging of adipose tissue . Methods Enzymol 537 , 47-73.", + "Church CD, Berry R, and Rodeheffer MS. (2014). Isolation and study of adipocyte precursors . Methods Enzymol 537, 47-73.", + "Gattu AK, Swenson ES, Iwakiri Y, Samuel VT, Troiano N, Berry R, Church CD, Rodeheffer MS, Carpenter TO, and Chung C. (2013). Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content . FASEB J 27 , 4384-4394.", + "Festa E, Fretz J, Berry R, Schmidt B, Rodeheffer MS, Horowitz M, and Horsley V. (2011). Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling . Cell 146 , 761-771.", + "Brady Memorial Laboratory 310 Cedar Street PO Box 208016 New Haven, CT 06520-8016", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Rose Lab", + "lab_url": "https://medicine.yale.edu/lab/rose/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/rose/publications/", + "publications": null + }, + { + "lab_name": "Rothman Lab", + "lab_url": "https://medicine.yale.edu/lab/rothman/", + "research_bio": "INFORMATION FOR Membrane fusion is a fundamental biological process for organelle formation, nutrient uptake, and the secretion of hormones and neurotransmitters. It is central to vesicular transport, storage, and release in many areas of endocrine and exocrine physiology, and imbalances in these processes give rise to important diseases, such as diabetes. We employ diverse biophysical, biochemical, and cell biological approaches to characterize the fundamental participants in intracellular transport processes. Over 30 years ago, we observed what we interpreted to be vesicular transport in crude extracts of tissue culture cells. In subsequent years we found... Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/rothman/publications/", + "publications": null + }, + { + "lab_name": "Roy Lab", + "lab_url": "https://medicine.yale.edu/lab/roy/", + "research_bio": "INFORMATION FOR Our focus is understanding the B cell dysfunction in inflammatory neuropathies, including acute and chronic inflammatory demyelinating polyneuropathies (AIDP and CIDP) and autoimmune nodopathies (AINs). We are combining bioinformatics and molecular biology to address some fundamental questions on disease pathomechanism and identify the key drivers underlying B cell dysfunction. This is a translational laboratory with our biorepository and national and international collaborations. The lab leverages well-curated human blood and tissue samples that are linked with clinical and demographic data, along with diagnostic studies. The lab’s goal is to identify new therapeutic targets for these diseases and improve patient care. We are also interested in studying inclusion body myositis (IBM), a type of idiopathic inflammatory myositis that does not have any treatment. Plasma cells are often noted in muscle biopsies of IBM patients, but their function in disease pathogenesis is unknown. We are using deep immunophenotyping to understand the impact of plasma cells in IBM. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Rudnick Laboratory", + "lab_url": "https://medicine.yale.edu/lab/rudnick/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/rudnick/publications/", + "publications": null + }, + { + "lab_name": "Sadeghi Lab", + "lab_url": "https://medicine.yale.edu/lab/sadeghi/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Safdar Lab", + "lab_url": "https://medicine.yale.edu/lab/safdar/", + "research_bio": "INFORMATION FOR Welcome to our lab, where we conduct sex and gender-specific research in microvascular health, focusing on the heart, brain, and COVID-19. Led by Dr. Safdar, our team includes a diverse group of researchers with varied expertise, and a broad grant portfolio from NIH, CDC, Foundations, and Investigator Initiated Industry awards. We have successfully conducted numerous clinical trials, epidemiological studies, and translational research projects. Our lab led the seminal work in describing coronary microvascular dysfunction (CMD) in emergency department patients using a clinical phenotype based on cardiac PET/CT. CMD predominantly affects female patients and is a cause of recurrent chest pain presentations to the ED. We now lead the Yale CMD Registry, a prospective registry and bio repository committed to comprehensive patient monitoring with a multi-system lens through an integrated, multidisciplinary clinical approach. We're not just researchers; we're collaborators. Actively engaging across diverse disciplines, federal and industry partners, we amplify our impact. Our exploration extends the thread of microvascular dysfunction beyond its cardiac manifestations, probing the systemic nature of the disease. Our work spans domains of cardiovascular health, cognitive dysfunction, COVID-19, and exercise and fitness, seamlessly integrating sex and gender-specific insights across diagnostic, mechanistic and therapeutic domains. Our objective extends beyond mere understanding; we aim to translate our findings into tangible advancements in patient care and public health. Through meticulous approach and with a multisystem team, we aim to develop precision-based tools for diagnosis, therapeutics, and risk prediction of microvascular dysfunction on clinical outcomes. Join us in pushing the boundaries of knowledge, as we strive to find new ways of diagnosing and treating microvascular dysfunction and push the frontiers of precison medicine. Dr. Safdar presenting the proteomics results of Yale-CMD registry at the European Scientific Congress in London, August 2024. Copy Link Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Sansing Lab", + "lab_url": "https://medicine.yale.edu/lab/sansing/", + "research_bio": "INFORMATION FOR Copy Link Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Schaefer Lab", + "lab_url": "https://medicine.yale.edu/lab/schaefer/", + "research_bio": "INFORMATION FOR Copy Link Throughout our bodies, human cells coexist with diverse and abundant bacteria, and a vast library of chemicals and macromolecules is exchanged between them.Our immune system plays dual physiological roles in this ecosystem, fighting against pathogenic bacteria while conversely maintaining complex, stable commensal populations. Concordantly, microbial networks play myriad and profound roles in human physiology and illness. To identify, understand, and modulate signaling at the human:microbe interface,our laboratory integratesleading-edge chemical biology, proteomics, microbiology, immunology, and structural biology. Copy Link We welcome enthusiastic and curious scientists from diverse personal and professional backgrounds. Our group strives to advance science and profoundly impact human health. Our mission requires tackling challenging science, and we value a positive work environment that promotes mentorship, communication, and transparent and rigorous science. Lab members should feel supported and a sense of agency in their work Reflecting our collaborative atmosphere within our lab, we are excited to work with the broader scientific community. Department of Microbial Pathogenesis, 295 Congress Ave. BCMM 345/443, New Haven, CT 06519, United States", + "publications_page": "https://medicine.yale.edu/lab/schaefer/publications/", + "publications": [ + "Yale School of Medicine /", + "Microbial Pathogenesis /", + "Our science", + "Join us", + "News", + "Publications", + "Our lab", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Our science", + "News", + "Publications", + "Our lab", + "Join us", + "", + "", + "", + "", + "", + "", + "Hypoxia Induces Extensive Protein and Proteolytic Remodeling of the Cell Surface in Pancreatic Adenocarcinoma (PDAC) Cell Lines Lui I, Schaefer K , Kirkemo L, Zhou J, Perera R, Leung K, Wells J. Hypoxia Induces Extensive Protein and Proteolytic Remodeling of the Cell Surface in Pancreatic Adenocarcinoma (PDAC) Cell Lines . Journal Of Proteome Research 2025, 24: 2791-2800. PMID: 40312771 , PMCID: PMC12161487 , DOI: 10.1021/acs.jproteome.4c01037 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Carcinoma, Pancreatic Ductal Cell Hypoxia Cell Line, Tumor Humans Membrane Proteins Pancreatic Neoplasms Proteolysis Proteomics Tumor Microenvironment Concepts Proteolytic remodeling Cell surface Pancreatic ductal adenocarcinoma Cell lines Cell surface proteins Upregulation of proteins Cellular response to hypoxia N-terminomics Tumor microenvironment Cellular processes Pancreatic ductal adenocarcinoma cell lines Surface proteins Shed proteins Metabolic processes Molecular events Tissue development Cellular adhesion Protein Mass spectrometry technology Cancer progression Hypoxia regulation Hypoxia-induced alterations Proteolysis Response to hypoxia Therapeutic target", + "Engineered Proteins and Chemical Tools to Probe the Cell Surface Proteome Leung K, Schaefer K , Lin Z, Yao Z, Wells J. Engineered Proteins and Chemical Tools to Probe the Cell Surface Proteome . Chemical Reviews 2025, 125: 4069-4110. PMID: 40178992 , PMCID: PMC12022999 , DOI: 10.1021/acs.chemrev.4c00554 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Humans Membrane Proteins Protein Engineering Protein Processing, Post-Translational Proteome Proteomics Concepts Proximity labeling proteomics Cell surface proteome Surface proteome Target discovery Proximity labeling techniques Protein-protein interactions Post-translational modifications Membrane protein complexes Cell surface glycosylation Cell surface proteins Peptide MHC complexes Extracellular post-translational modification Disease-associated changes Labeling proteomics Protein complexes Proteome level Proteomic approach Surface glycosylation Engineered proteins Surfaceome Proteolytic remodeling Surface proteins Proteomics Functional importance Cell surface", + "Multiscale photocatalytic proximity labeling reveals cell surface neighbors on and between cells Lin Z, Schaefer K , Lui I, Yao Z, Fossati A, Swaney D, Palar A, Sali A, Wells J. Multiscale photocatalytic proximity labeling reveals cell surface neighbors on and between cells . Science 2024, 385: eadl5763. PMID: 39024454 , DOI: 10.1126/science.adl5763 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Catalysis Cell Membrane Eosine Yellowish-(YS) ErbB Receptors Fluorescent Dyes Humans Light Photochemical Processes Protein Interaction Maps Proteomics Receptors, Chimeric Antigen Staining and Labeling T-Lymphocytes Concepts Proximity labeling proteomics Protein neighborhoods Oncogenic epidermal growth factor receptor Proximity labeling AlphaFold-Multimer Labeling radius Labeling proteomics Protein network Cell surface Epidermal growth factor receptor Visible light illumination Growth factor receptor Photo-probes Factor receptor Eosin Y Cells Light illumination Interactome", + "Direct Identification of Proteolytic Cleavages on Living Cells Using a Glycan-Tethered Peptide Ligase Schaefer K , Lui I, Byrnes J, Kang E, Zhou J, Weeks A, Wells J. Direct Identification of Proteolytic Cleavages on Living Cells Using a Glycan-Tethered Peptide Ligase . ACS Central Science 2022, 8: 1447-1456. PMID: 36313159 , PMCID: PMC9615116 , DOI: 10.1021/acscentsci.2c00899 . Peer-Reviewed Original Research Citations Altmetric Concepts Neo-N-termini Proteolytic cleavage N-terminomics Peptide ligase N-terminal nucleophile Remodeling of proteins Living cells Cell surface proteins Surface of living cells Cancer cell growth Cell-cell interactions Malignant cell phenotype Extracellular proteases Cleavage site Cellular context Signaling proteins Membrane proteins Proteomic approach Proteomic analysis Proteomic studies Surface proteins Cell growth Cell types Protein Ligase", + "Lipoteichoic acid polymer length is determined by competition between free starter units Hesser A, Schaefer K , Lee W, Walker S. Lipoteichoic acid polymer length is determined by competition between free starter units . Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 29669-29676. PMID: 33172991 , PMCID: PMC7703640 , DOI: 10.1073/pnas.2008929117 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Bacterial Proteins Cell Membrane Glycolipids Lipids Lipopolysaccharides Polymers Staphylococcus aureus Teichoic Acids Concepts Starter unit Gram-positive bacteria Lipoteichoic acid Alternative starter units Lipoteichoic acid synthase Lipoteichoic acid polymers Polymer length Carbohydrate polymers Anionic glycopolymers Diglucosyl diacylglycerol Lipid anchor Acid synthase Extracellular leaflet Biological functions Cell growth Reconstituted system Binding sites LtaS Phosphatidylglycerol Cell membrane Structural diversity Bacteria Short polymers Polymer Enzyme", + "Structure and reconstitution of a hydrolase complex that may release peptidoglycan from the membrane after polymerization Schaefer K , Owens T, Page J, Santiago M, Kahne D, Walker S. Structure and reconstitution of a hydrolase complex that may release peptidoglycan from the membrane after polymerization . Nature Microbiology 2020, 6: 34-43. PMID: 33168989 , PMCID: PMC7755832 , DOI: 10.1038/s41564-020-00808-5 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Cell Membrane Cell Wall Hydrolases Membrane Proteins Peptidoglycan Staphylococcus aureus Uridine Diphosphate N-Acetylmuramic Acid Concepts Mature peptidoglycan Lipid II Membrane proteins Polytopic membrane proteins Peptidoglycan cell wall Cell wall assembly Cell wall hydrolases CaaX proteases Glycan strands Cell wall matrix Nascent peptidoglycan Membrane-anchored Transmembrane helices Peptidoglycan strands Peptidoglycan Peptidoglycan polymer Cell wall Protein scaffold Hydrolase Wall assembly Wall matrix Bacteria Active site Protein Membrane", + "An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike Schoof M, Faust B, Saunders R, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle C, Puchades C, Azumaya C, Kratochvil H, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen H, Chio C, Merz G, Thompson M, Diwanji D, Schaefer K , Anand A, Dobzinski N, Zha B, Simoneau C, Leon K, White K, Chio U, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith A, Rizo A, Moss F, Brilot A, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill A, Nock S, Liu Y, Krogan N, Ralston C, Swaney D, García-Sastre A, Ott M, Vignuzzi M, Walter P, Manglik A, Azumaya C, Puchades C, Sun M, Braxton J, Brilot A, Gupta M, Li F, Lopez K, Melo A, Merz G, Moss F, Paulino J, Pospiech T, Pourmal S, Rizo A, Smith A, Thomas P, Wang F, Yu Z, Dickinson M, Nguyen H, Asarnow D, Campbell M, Chio C, Chio U, Diwanji D, Faust B, Gupta M, Hoppe N, Jin M, Li J, Liu Y, Merz G, Sangwan S, Tsui T, Trenker R, Trinidad D, Tse E, Zhang K, Zhou F, Herrera N, Kratochvil H, Schulze-Gahmen U, Thompson M, Young I, Biel J, Deshpande I, Liu X, Billesbølle C, Nowotny C, Smith A, Zhao J, Bowen A, Hoppe N, Li Y, Nguyen P, Safari M, Schaefer K, Whitis N, Moritz M, Owens T, Diallo A, Kim K, Peters J, Titus E, Chen J, Doan L, Flores S, Lam V, Li Y, Lo M, Thwin A, Wankowicz S, Zhang Y, Bulkley D, Joves A, Joves A, McKay L, Tabios M, Rosenberg O, Verba K, Agard D, Cheng Y, Fraser J, Frost A, Jura N, Kortemme T, Krogan N, Manglik A, Southworth D, Stroud R. An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike . Science 2020, 370: 1473-1479. PMID: 33154106 , PMCID: PMC7857409 , DOI: 10.1126/science.abe3255 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Angiotensin-Converting Enzyme 2 Animals Antibodies, Neutralizing Antibodies, Viral Antibody Affinity Chlorocebus aethiops Cryoelectron Microscopy Humans Neutralization Tests Protein Binding Protein Stability Single-Domain Antibodies Spike Glycoprotein, Coronavirus Vero Cells Concepts Angiotensin-converting enzyme 2 Structure-guided design Cell receptor angiotensin-converting enzyme 2 Host cell receptor angiotensin-converting enzyme 2 Binds angiotensin-converting enzyme 2 Receptor angiotensin-converting enzyme 2 Cryo-electron microscopy Receptor-binding domain Binding domain Femtomolar affinity Host cells Inactive conformation Synthetic nanobodies Nanobody sequences Cryo-EM Spike protein SARS-CoV-2 infection Nanobodies Affinity maturation Airway epithelia Enzyme 2 Severe acute respiratory syndrome coronavirus 2 Acute respiratory syndrome coronavirus 2 Trivalent nanobody Respiratory syndrome coronavirus 2", + "Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms Gordon D, Hiatt J, Bouhaddou M, Rezelj V, Ulferts S, Braberg H, Jureka A, Obernier K, Guo J, Batra J, Kaake R, Weckstein A, Owens T, Gupta M, Pourmal S, Titus E, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O’Meara M, Tummino T, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney D, Fabius J, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas K, Naing Z, Pulido E, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero M, Burke D, Koh C, Vallet T, Silvas J, Azumaya C, Billesbølle C, Brilot A, Campbell M, Diallo A, Dickinson M, Diwanji D, Herrera N, Hoppe N, Kratochvil H, Liu Y, Merz G, Moritz M, Nguyen H, Nowotny C, Puchades C, Rizo A, Schulze-Gahmen U, Smith A, Sun M, Young I, Zhao J, Asarnow D, Biel J, Bowen A, Braxton J, Chen J, Chio C, Chio U, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam V, Li F, Li J, Li Y, Li Y, Liu X, Lo M, Lopez K, Melo A, Moss F, Nguyen P, Paulino J, Pawar K, Peters J, Pospiech T, Safari M, Sangwan S, Schaefer K , Thomas P, Thwin A, Trenker R, Tse E, Tsui T, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, Hodder A, Shun-Shion A, Williams D, White K, Rosales R, Kehrer T, Miorin L, Moreno E, Patel A, Rihn S, Khalid M, Vallejo-Gracia A, Fozouni P, Simoneau C, Roth T, Wu D, Karim M, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie C, Elliott M, Brown F, Burness K, Reid E, Dorward M, Johnson C, Wilkinson S, Geyer A, Giesel D, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough K, Lind A, Klesh R, Hemphill K, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard K, Sali A, Agard D, Cheng Y, Fraser J, Frost A, Jura N, Kortemme T, Manglik A, Southworth D, Stroud R, Alessi D, Davies P, Frieman M, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, Shokat K, García-Sastre A, Rassen J, Grosse R, Rosenberg O, Verba K, Basler C, Vignuzzi M, Peden A, Beltrao P, Krogan N, Owens T, Gupta M, Pourmal S, Titus E, Azumaya C, Billesbølle C, Brilot A, Campbell M, Diallo A, Dickinson M, Diwanji D, Herrera N, Hoppe N, Kratochvil H, Liu Y, Merz G, Moritz M, Nguyen H, Nowotny C, Puchades C, Rizo A, Schulze-Gahmen U, Smith A, Sun M, Young I, Zhao J, Asarnow D, Biel J, Bowen A, Braxton J, Chen J, Chio C, Chio U, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam V, Li F, Li J, Li Y, Li Y, Liu X, Lo M, Lopez K, Melo A, Moss F, Nguyen P, Paulino J, Pawar K, Peters J, Pospiech T, Safari M, Sangwan S, Schaefer K, Thomas P, Thwin A, Trenker R, Tse E, Tsui T, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Trinidad D, Agard D, Cheng Y, Fraser J, Frost A, Jura N, Kortemme T, Manglik A, Southworth D, Stroud R, Rosenberg O, Verba K, Damas J, Hughes G, Keough K, Painter C, Persky N, Corbo M, Kirilenko B, Hiller M, Koepfli K, Kaplow I, Wirthlin M, Pfenning A, Zhao H, Genereux D, Swofford R, Lind A, Pollard K, Ryderq O, Nweeia M, Meadows J, Dong M, Wallerman O, Marinescu V, Lindblad-Toh K, Ray D, Power S, Teeling E, Chauhan G, Li S, Karlsson E, Lewin H. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms . Science 2020, 370: eabe9403. PMID: 33060197 , PMCID: PMC7808408 , DOI: 10.1126/science.abe9403 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Conserved Sequence Coronavirus Nucleocapsid Proteins COVID-19 Cryoelectron Microscopy Host Microbial Interactions Humans Mitochondrial Membrane Transport Proteins Mitochondrial Precursor Protein Import Complex Proteins Phosphoproteins Protein Conformation Protein Interaction Maps SARS-CoV-2 Severe Acute Respiratory Syndrome Severe acute respiratory syndrome-related coronavirus Concepts SARS-CoV-1 SARS-CoV-2 ORF9b Protein localization analysis Protein interaction network Mitochondrial chaperone protein Protein-protein interactions Functional genetic screens Host factors Patient genetic data Cryo-electron microscopy Genetic data Genetic screening Interaction network Chaperone proteins SARS-CoV-2 Molecular mechanisms Middle East respiratory syndrome coronavirus Potential drug treatments Disease mechanisms Respiratory syndrome coronavirus MERS-CoV Local analysis Syndrome coronavirus Coronavirus proliferation Host", + "Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan Do T, Schaefer K , Santiago A, Coe K, Fernandes P, Kahne D, Pinho M, Walker S. Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan . Nature Microbiology 2020, 5: 291-303. PMID: 31932712 , PMCID: PMC7046134 , DOI: 10.1038/s41564-019-0632-1 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Bacterial Proteins Cell Cycle Cell Division Gene Deletion Genes, Bacterial Models, Biological Mutation N-Acetylmuramoyl-L-alanine Amidase Peptidoglycan Recombinant Proteins Staphylococcus aureus Substrate Specificity Concepts Peptidoglycan synthesis Cell division Cell growth Uncrosslinked peptidoglycan Stem peptides Cell cycle Defects due to loss Membrane protein complexes Transposon screen Peptidoglycan synthases Division site Partner proteins Assembled enzyme Subcellular location Cell periphery Polymerase activity Protein complexes Daughter cells Peptidoglycan Assembly sites Staphylococcus aureus Amidase Cell expansion Synthase activity Peptide", + "Direction of Chain Growth and Substrate Preferences of Shape, Elongation, Division, and Sporulation-Family Peptidoglycan Glycosyltransferases Welsh M, Schaefer K , Taguchi A, Kahne D, Walker S. Direction of Chain Growth and Substrate Preferences of Shape, Elongation, Division, and Sporulation-Family Peptidoglycan Glycosyltransferases . Journal Of The American Chemical Society 2019, 141: 12994-12997. PMID: 31386359 , PMCID: PMC6738341 , DOI: 10.1021/jacs.9b06358 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Bacterial Proteins Biosynthetic Pathways Humans Peptidoglycan Peptidoglycan Glycosyltransferase Staphylococcal Infections Staphylococcus aureus Substrate Specificity Concepts Peptidoglycan glycosyltransferases Substrate preference Lipid II Cell wall Mature cell walls Bacterial cell wall Glycan strands SEDS proteins Glycan chains Decades bacteria Peptidoglycan polymerases Peptidoglycan Glycopeptide precursors Lipid requirements FtsW II monomer Glycosyltransferases Polymerase Glycans Structural studies Bacteria RodA Enzyme Lipid Antibiotics", + "MreB filaments align along greatest principal membrane curvature to orient cell wall synthesis Hussain S, Wivagg C, Szwedziak P, Wong F, Schaefer K , Izoré T, Renner L, Holmes M, Sun Y, Bisson-Filho A, Walker S, Amir A, Löwe J, Garner E. MreB filaments align along greatest principal membrane curvature to orient cell wall synthesis . ELife 2018, 7: e32471. PMID: 29469806 , PMCID: PMC5854468 , DOI: 10.7554/elife.32471 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Bacillus subtilis Bacterial Proteins Cell Membrane Cell Wall Peptidoglycan Protein Transport Concepts MreB motion MreB filaments Membrane curvature Stable maintenance Principal membrane curvatures Cell wall synthesis Rod shape Wall synthesis MreB Peptidoglycan synthesis Cell wall Spherical cells Filaments Cells Biophysical model Stationary filaments Protoplasts", + "Substrate Preferences Establish the Order of Cell Wall Assembly in Staphylococcus aureus Schaefer K , Owens T, Kahne D, Walker S. Substrate Preferences Establish the Order of Cell Wall Assembly in Staphylococcus aureus . Journal Of The American Chemical Society 2018, 140: 2442-2445. PMID: 29402087 , PMCID: PMC5870139 , DOI: 10.1021/jacs.7b13551 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Carbohydrate Conformation Cell Wall Ligases Models, Molecular Peptidoglycan Staphylococcus aureus Substrate Specificity Teichoic Acids Concepts Cell wall assembly Cross-linked peptidoglycan Biosynthetic pathway Peptidoglycan binding site Wall assembly Stages of peptidoglycan synthesis Gram-positive bacterial cell wall Complex biosynthetic pathways Wall teichoic acid Bacterial cell wall Peptidoglycan substrate Acid precursors Peptidoglycan intermediates Peptidoglycan synthesis Un-cross-linked Protein ligase Stem peptides Substrate preference Peptidoglycan chains Teichoic acid Supramolecular structures Peptidoglycan Biosynthetic events Chitin oligomers Ligase", + "Identification of a Functionally Unique Family of Penicillin-Binding Proteins Welsh M, Taguchi A, Schaefer K , Van Tyne D, Lebreton F, Gilmore M, Kahne D, Walker S. Identification of a Functionally Unique Family of Penicillin-Binding Proteins . Journal Of The American Chemical Society 2017, 139: 17727-17730. PMID: 29182854 , PMCID: PMC5729098 , DOI: 10.1021/jacs.7b10170 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Amines Bacterial Proteins Catalytic Domain Cell Wall Enterococcus faecalis Lysine Molecular Weight Penicillin-Binding Proteins Peptidoglycan Peptidyl Transferases Streptococcus gordonii Uridine Diphosphate N-Acetylmuramic Acid Concepts Penicillin-binding proteins Low-molecular-weight penicillin-binding proteins Family of penicillin-binding proteins Unique family High-molecular-weight penicillin-binding proteins Biochemical studies Cell wall assembly Peptidoglycan cross-linking Biochemical studies of proteins Bacterial cell wall Study of proteins D-amino acids Peptidoglycan precursors Lipid II Peptidoglycan Cell wall Affinity handles D-amino Protein Wall assembly Hydrolase Chemical tagging", + "Peptidoglycan Cross-Linking Preferences of Staphylococcus aureus Penicillin-Binding Proteins Have Implications for Treating MRSA Infections Srisuknimit V, Qiao Y, Schaefer K , Kahne D, Walker S. Peptidoglycan Cross-Linking Preferences of Staphylococcus aureus Penicillin-Binding Proteins Have Implications for Treating MRSA Infections . Journal Of The American Chemical Society 2017, 139: 9791-9794. PMID: 28691491 , PMCID: PMC5613940 , DOI: 10.1021/jacs.7b04881 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Anti-Bacterial Agents beta-Lactams Cross-Linking Reagents Methicillin-Resistant Staphylococcus aureus Molecular Structure Penicillin-Binding Proteins Peptidoglycan Peptidyl Transferases Staphylococcal Infections Concepts Methicillin-resistant Staphylococcus aureus Cross-linked peptidoglycan Peptidoglycan strands Methicillin-resistant Staphylococcus aureus strains B-lactam Treat MRSA infections Cell wall precursors Penicillin-binding proteins Glycan strands Lipid II Wall precursors PBP2a Branch lengths MRSA infections Peptidoglycan Global public health problem Public health problem Monoglycine Protein Strands PBP Small molecules Ideal target Cells Glycine", + "Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams Qiao Y, Srisuknimit V, Rubino F, Schaefer K , Ruiz N, Walker S, Kahne D. Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams . Nature Chemical Biology 2017, 13: 793-798. PMID: 28553948 , PMCID: PMC5478438 , DOI: 10.1038/nchembio.2388 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Bacterial Proteins beta-Lactams Cell Wall Lipids Molecular Structure Penicillin-Binding Proteins Peptidyl Transferases Staphylococcus aureus Concepts B-lactam Lipid II", + "In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins Schaefer K , Matano L, Qiao Y, Kahne D, Walker S. In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins . Nature Chemical Biology 2017, 13: 396-401. PMID: 28166208 , PMCID: PMC5362317 , DOI: 10.1038/nchembio.2302 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Bacterial Proteins Cell Wall In Vitro Techniques Ligases Molecular Structure Peptidoglycan Staphylococcus aureus Concepts Staphylococcus aureus cell wall In vitro reconstitution LCP proteins Family proteins Cell wall Reconstitution experiments Chemoenzymatic synthesis Protein Peptidoglycan Biosynthesis Reconstitution Cells", + "The Mechanism of Action of Lysobactin Lee W, Schaefer K , Qiao Y, Srisuknimit V, Steinmetz H, Müller R, Kahne D, Walker S. The Mechanism of Action of Lysobactin . Journal Of The American Chemical Society 2015, 138: 100-103. PMID: 26683668 , PMCID: PMC4817722 , DOI: 10.1021/jacs.5b11807 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Depsipeptides Microscopy, Electron, Transmission Staphylococcus aureus Streptococcus pneumoniae Concepts Wall teichoic acid Molecular mechanisms Cell envelope damage Cell wall precursors Lipid II binding Molecular mechanisms of action Mechanism of killing Biosynthetic pathway Lipid I Lipid II Wall precursors Teichoic acid Envelope damage Staphylococcus aureus Lysobactin Peptidoglycan Enzyme inhibition assay II binding In vivo efficacy Mechanism of action Inhibition assay Septal defect Pathway Lipid Biosynthesis", + "Detection of Lipid-Linked Peptidoglycan Precursors by Exploiting an Unexpected Transpeptidase Reaction Qiao Y, Lebar M, Schirner K, Schaefer K , Tsukamoto H, Kahne D, Walker S. Detection of Lipid-Linked Peptidoglycan Precursors by Exploiting an Unexpected Transpeptidase Reaction . Journal Of The American Chemical Society 2014, 136: 14678-14681. PMID: 25291014 , PMCID: PMC4210121 , DOI: 10.1021/ja508147s . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Bacterial Proteins Monosaccharides Oligopeptides Penicillin-Binding Proteins Peptidoglycan Peptidyl Transferases Protein Structure, Tertiary Staphylococcus aureus Uridine Diphosphate N-Acetylmuramic Acid Concepts Penicillin-binding proteins D-amino acids Lipid II Exogenous d-amino acids Antibiotic mechanism of action Cross-linked PG Peptidoglycan precursors Lipid I Antibiotic mechanisms Bacterial peptidoglycan Genetic studies PBP4 S. aureus TP domain Staphylococcus aureus Transpeptidase reaction Enzymatic activity Low abundance Pharmacological perturbations Activity in vivo Biochemical studies Cellular PG Peptidoglycan PG polymers Sensitive assay", + "Maps & Directions", + "Calendar", + "Contact Us", + "", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Schalper Lab", + "lab_url": "https://medicine.yale.edu/lab/schalper/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Scharfe Laboratory", + "lab_url": "https://medicine.yale.edu/lab/scharfe/", + "research_bio": "INFORMATION FOR Our laboratory develops new tools and genomic approaches for molecular screening and diagnostics and the study of disease pathogenesis. We couple experimental and computational techniques to fully integrate all steps of highly multiplexed molecular assays, which include nucleic acid extraction from small and challenging clinical samples, targeted (multi-gene panels, exome) and genome sequencing, detection of rare single nucleotide and copy number variants, and data interpretation in the context of clinical findings. We use laboratory automation to increase assay precision and speed, and work on implementing these techniques into rapid disease screening and diagnostics. Our lab is located in a highly translational setting next to theYale DNA Diagnostic Laboratoryand we collaborate with clinical colleagues and researcher at Yale and other institutions. Please read here about our most recent projects. Copy Link Are you excited about genetic disease research and diagnostics and do you want to make an impact in medicine? We are always seeking talented students, postdocs, programmers, and researchers with outstanding experimental and/or computational skills or have a strong interest in developing such skills. For more information, send an email toDr Curt Scharfe. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/scharfe/publications/", + "publications": [ + "Yale School of Medicine /", + "Genetics /", + "Research Newborn Screening (NBS) Rapid Genotyping to Improve Patient Care Multiplex Microhaplotype Sequencing (mMHseq) Multiplex Viral Sequencing (mVseq)", + "Newborn Screening (NBS)", + "Rapid Genotyping to Improve Patient Care", + "Multiplex Microhaplotype Sequencing (mMHseq)", + "Multiplex Viral Sequencing (mVseq)", + "Publications", + "People", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Publications", + "People", + "", + "", + "", + "", + "", + "", + "Laboratory considerations for GRCh37 to GRCh38 reference genome transition: A laboratory quality assurance bulletin of the American College of Medical Genetics and Genomics (ACMG). Aggarwal VS, Guha S, Lebo MS, Retterer K, Scharfe C, Bean LJH. Genet Med Open. 2025; 2025 Jul 24. PMID: 40747514.", + "Beyond the Evidence: How Race, Chronological Age, and Developmental Age Shape Juror Verdicts in Sexual Assault Cases. Fraser BM, Pica E, Pozzulo JD, Korn J, Scharfe C. Behav Sci Law. 2025 Jul-Aug; 2025 May 7. PMID: 40331924.", + "Allele-specific electrical genotyping for diagnosis of transthyretin amyloidosis. Tayyab M, Gandotra N, Sui J, Scharfe C, Javanmard M. Commun Eng. 2025 Mar 13; 2025 Mar 13. PMID: 40082707.", + "CFTR haplotype phasing using long-read genome sequencing from ultralow input DNA. Gandotra N, Tyagi A, Tikhonova I, Storer C, Scharfe C. Genet Med Open. 2025; 2025 Jan 7. PMID: 40027236.", + "Phenylalanine hydroxylase deficiency diagnosis and management: A 2023 evidence-based clinical guideline of the American College of Medical Genetics and Genomics (ACMG). Smith WE, Berry SA, Bloom K, Brown C, Burton BK, Demarest OM, Jenkins GP, Malinowski J, McBride KL, Mroczkowski HJ, Scharfe C, Vockley J. Genet Med. 2025 Jan; 2024 Dec 4. PMID: 39630157.", + "Association of Maternal Age and Blood Markers for Metabolic Disease in Newborns. Xie Y, Peng G, Zhao H, Scharfe C. Metabolites. 2023 Dec 20; 2023 Dec 20. PMID: 38276295.", + "NBSTRN Tools to Advance Newborn Screening Research and Support Newborn Screening Stakeholders. Chan K, Hu Z, Bush LW, Cope H, Holm IA, Kingsmore SF, Wilhelm K, Scharfe C, Brower A. Int J Neonatal Screen. 2023 Oct 30; 2023 Oct 30. PMID: 37987476.", + "Digital assay for rapid electronic quantification of clinical pathogens using DNA nanoballs. Tayyab M, Barrett D, van Riel G, Liu S, Reinius B, Scharfe C, Griffin P, Steinmetz LM, Javanmard M, Pelechano V. Sci Adv. 2023 Sep 8; 2023 Sep 6. PMID: 37672583.", + "Contributions from medical geneticists in clinical trials of genetic therapies: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG). Peña LDM, Burrage LC, Enns GM, Esplin ED, Harding C, Mendell JR, Niu ZN, Scharfe C, Yu T, Koeberl DD. Genet Med. 2023 Jun; 2023 Apr 9. PMID: 37031408.", + "Validation of a targeted metabolomics panel for improved second-tier newborn screening. Mak J, Peng G, Le A, Gandotra N, Enns GM, Scharfe C, Cowan TM. J Inherit Metab Dis. 2023 Mar; 2023 Feb 2. PMID: 36680545.", + "Nucleic Acid Quantification by Multi-Frequency Impedance Cytometry and Machine Learning. Kokabi M, Sui J, Gandotra N, Pournadali Khamseh A, Scharfe C, Javanmard M. Biosensors (Basel). 2023 Feb 24; 2023 Feb 24. PMID: 36979528.", + "A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension. Gunawardhana KL, Hong L, Rugira T, Uebbing S, Kucharczak J, Mehta S, Karunamuni DR, Cabera-Mendoza B, Gandotra N, Scharfe C, Polimanti R, Noonan JP, Mani A. J Clin Invest. 2023 Feb 15; 2023 Feb 15. PMID: 36602864.", + "Metabolic diversity in human populations and correlation with genetic and ancestral geographic distances. Peng G, Pakstis AJ, Gandotra N, Cowan TM, Zhao H, Kidd KK, Scharfe C. Mol Genet Metab. 2022 Nov; 2022 Oct 13. PMID: 36252453.", + "A multipurpose panel of microhaplotypes for use with STR markers in casework. Kidd KK, Pakstis AJ, Gandotra N, Scharfe C, Podini D. Forensic Sci Int Genet. 2022 Sep; 2022 Jun 3. PMID: 35696960.", + "dbRUSP: An Interactive Database to Investigate Inborn Metabolic Differences for Improved Genetic Disease Screening. Peng G, Zhang Y, Zhao H, Scharfe C. Int J Neonatal Screen. 2022 Aug 29; 2022 Aug 29. PMID: 36135348.", + "Population-Based Screening of Newborns: Findings From the NBS Expansion Study (Part One). Brower A, Chan K, Williams M, Berry S, Currier R, Rinaldo P, Caggana M, Gaviglio A, Wilcox W, Steiner R, Holm IA, Taylor J, Orsini JJ, Brunelli L, Adelberg J, Bodamer O, Viall S, Scharfe C, Wasserstein M, Chen JY, Escolar M, Goldenberg A, Swoboda K, Ficicioglu C, Matern D, Lee R, Watson M. Front Genet. 2022; 2022 Jul 22. PMID: 35938011.", + "The population genetics characteristics of a 90 locus panel of microhaplotypes. Pakstis AJ, Gandotra N, Speed WC, Murtha M, Scharfe C, Kidd KK. Hum Genet. 2021 Dec; 2021 Oct 13. PMID: 34643790.", + "Multi-frequency impedance sensing for detection and sizing of DNA fragments. Sui J, Gandotra N, Xie P, Lin Z, Scharfe C, Javanmard M. Sci Rep. 2021 Mar 22; 2021 Mar 22. PMID: 33753781.", + "Timing of Newborn Blood Collection Alters Metabolic Disease Screening Performance. Peng G, Tang Y, Cowan TM, Zhao H, Scharfe C. Front Pediatr. 2020; 2021 Jan 20. PMID: 33553077.", + "Massively parallel discovery of human-specific substitutions that alter enhancer activity. Uebbing S, Gockley J, Reilly SK, Kocher AA, Geller E, Gandotra N, Scharfe C, Cotney J, Noonan JP. Proc Natl Acad Sci U S A. 2021 Jan 12. PMID: 33372131.", + "Ethnic variability in newborn metabolic screening markers associated with false-positive outcomes. Peng G, Tang Y, Gandotra N, Enns GM, Cowan TM, Zhao H, Scharfe C. J Inherit Metab Dis. 2020 Sep; 2020 Apr 17. PMID: 32216101.", + "Validation of novel forensic DNA markers using multiplex microhaplotype sequencing. Gandotra N, Speed WC, Qin W, Tang Y, Pakstis AJ, Kidd KK, Scharfe C. Forensic Sci Int Genet. 2020 Jul; 2020 Mar 18. PMID: 32305739.", + "Reducing False-Positive Results in Newborn Screening Using Machine Learning. Peng G, Tang Y, Cowan TM, Enns GM, Zhao H, Scharfe C. Int J Neonatal Screen. 2020 Mar; 2020 Mar 3. PMID: 32190768.", + "Assessment of network module identification across complex diseases. Choobdar S, Ahsen ME, Crawford J, Tomasoni M, Fang T, Lamparter D, Lin J, Hescott B, Hu X, Mercer J, Natoli T, Narayan R, Subramanian A, Zhang JD, Stolovitzky G, Kutalik Z, Lage K, Slonim DK, Saez-Rodriguez J, Cowen LJ, Bergmann S, Marbach D. Nat Methods. 2019 Sep; 2019 Aug 30. PMID: 31471613.", + "Combining newborn metabolic and DNA analysis for second-tier testing of methylmalonic acidemia. Peng G, Shen P, Gandotra N, Le A, Fung E, Jelliffe-Pawlowski L, Davis RW, Enns GM, Zhao H, Cowan TM, Scharfe C. Genet Med. 2019 Apr; 2018 Sep 13. PMID: 30209273.", + "Elevated methylmalonic acidemia (MMA) screening markers in Hispanic and preterm newborns. Peng G, de Fontnouvelle CA, Enns GM, Cowan TM, Zhao H, Scharfe C. Mol Genet Metab. 2019 Jan; 2018 Nov 10. PMID: 30448007.", + "Transplant Virus Detection Using Multiplex Targeted Sequencing. Tan SK, Shen P, Lefterova MI, Sahoo MK, Fung E, Odegaard JI, Davis RW, Pinsky BA, Scharfe C. J Appl Lab Med. 2018 Mar. PMID: 31245786.", + "Common data elements for clinical research in mitochondrial disease: a National Institute for Neurological Disorders and Stroke project. Karaa A, Rahman S, Lombès A, Yu-Wai-Man P, Sheikh MK, Alai-Hansen S, Cohen BH, Dimmock D, Emrick L, Falk MJ, McCormack S, Mirsky D, Moore T, Parikh S, Shoffner J, Taivassalo T, Tarnopolsky M, Tein I, Odenkirchen JC, Goldstein A. J Inherit Metab Dis. 2017 May; 2017 Mar 16. PMID: 28303425.", + "Acylcarnitine Profiles Reflect Metabolic Vulnerability for Necrotizing Enterocolitis in Newborns Born Premature. Sylvester KG, Kastenberg ZJ, Moss RL, Enns GM, Cowan TM, Shaw GM, Stevenson DK, Sinclair TJ, Scharfe C, Ryckman KK, Jelliffe-Pawlowski LL. J Pediatr. 2017 Feb; 2016 Nov 8. PMID: 27836286.", + "Next-Generation Molecular Testing of Newborn Dried Blood Spots for Cystic Fibrosis. Lefterova MI, Shen P, Odegaard JI, Fung E, Chiang T, Peng G, Davis RW, Wang W, Kharrazi M, Schrijver I, Scharfe C. J Mol Diagn. 2016 Mar; 2016 Feb 1. PMID: 26847993.", + "A Rapid, High-Quality, Cost-Effective, Comprehensive and Expandable Targeted Next-Generation Sequencing Assay for Inherited Heart Diseases. Wilson KD, Shen P, Fung E, Karakikes I, Zhang A, InanlooRahatloo K, Odegaard J, Sallam K, Davis RW, Lui GK, Ashley EA, Scharfe C, Wu JC. Circ Res. 2015 Sep 11; 2015 Aug 11. PMID: 26265630.", + "A functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system. Schlecht U, Suresh S, Xu W, Aparicio AM, Chu A, Proctor MJ, Davis RW, Scharfe C, St Onge RP. BMC Genomics. 2014 Apr 5; 2014 Apr 5. PMID: 24708151.", + "Multiplex target capture with double-stranded DNA probes. Shen P, Wang W, Chi AK, Fan Y, Davis RW, Scharfe C. Genome Med. 2013; 2013 May 29. PMID: 23718862.", + "Rare variant detection using family-based sequencing analysis. Peng G, Fan Y, Palculict TB, Shen P, Ruteshouser EC, Chi AK, Davis RW, Huff V, Scharfe C, Wang W. Proc Natl Acad Sci U S A. 2013 Mar 5; 2013 Feb 20. PMID: 23426633.", + "Forward chemical genetics in yeast for discovery of chemical probes targeting metabolism. St Onge R, Schlecht U, Scharfe C, Evangelista M. Molecules. 2012 Nov 5; 2012 Nov 5. PMID: 23128089.", + "SRMA: an R package for resequencing array data analysis. Zhang N, Xu Y, O'Hely M, Speed TP, Scharfe C, Wang W. Bioinformatics. 2012 Jul 15; 2012 May 10. PMID: 22581181.", + "High-quality DNA sequence capture of 524 disease candidate genes. Shen P, Wang W, Krishnakumar S, Palm C, Chi AK, Enns GM, Davis RW, Speed TP, Mindrinos MN, Scharfe C. Proc Natl Acad Sci U S A. 2011 Apr 19; 2011 Apr 5. PMID: 21467225.", + "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing. Wang W, Shen P, Thiyagarajan S, Lin S, Palm C, Horvath R, Klopstock T, Cutler D, Pique L, Schrijver I, Davis RW, Mindrinos M, Speed TP, Scharfe C. Nucleic Acids Res. 2011 Jan; 2010 Sep 15. PMID: 20843780.", + "Semi-automated library preparation for high-throughput DNA sequencing platforms. Farias-Hesson E, Erikson J, Atkins A, Shen P, Davis RW, Scharfe C, Pourmand N. J Biomed Biotechnol. 2010; 2010 Jun 8. PMID: 20625503.", + "Mapping gene associations in human mitochondria using clinical disease phenotypes. Scharfe C, Lu HH, Neuenburg JK, Allen EA, Li GC, Klopstock T, Cowan TM, Enns GM, Davis RW. PLoS Comput Biol. 2009 Apr; 2009 Apr 24. PMID: 19390613.", + "Mitochondrial DNA analysis by multiplex denaturing high-performance liquid chromatography and selective sequencing in pediatric patients with cardiomyopathy. Schrijver I, Pique LM, Traynis I, Scharfe C, Sehnert AJ. Genet Med. 2009 Feb. PMID: 19265752.", + "MitoP2: the mitochondrial proteome database--now including mouse data. Prokisch H, Andreoli C, Ahting U, Heiss K, Ruepp A, Scharfe C, Meitinger T. Nucleic Acids Res. 2006 Jan 1. PMID: 16381964.", + "Proteome analysis of mitochondrial outer membrane from Neurospora crassa. Schmitt S, Prokisch H, Schlunck T, Camp DG 2nd, Ahting U, Waizenegger T, Scharfe C, Meitinger T, Imhof A, Neupert W, Oefner PJ, Rapaport D. Proteomics. 2006 Jan. PMID: 16294304.", + "The role of selection in the evolution of human mitochondrial genomes. Kivisild T, Shen P, Wall DP, Do B, Sung R, Davis K, Passarino G, Underhill PA, Scharfe C, Torroni A, Scozzari R, Modiano D, Coppa A, de Knijff P, Feldman M, Cavalli-Sforza LL, Oefner PJ. Genetics. 2006 Jan; 2005 Sep 19. PMID: 16172508.", + "Identifying new candidate genes for hereditary facial paresis on chromosome 3q21-q22 by RNA in situ hybridization in mouse. van der Zwaag B, Burbach JP, Scharfe C, Oefner PJ, Brunner HG, Padberg GW, van Bokhoven H. Genomics. 2005 Jul; 2005 Apr 20. PMID: 15953540.", + "Integrative analysis of the mitochondrial proteome in yeast. Prokisch H, Scharfe C, Camp DG 2nd, Xiao W, David L, Andreoli C, Monroe ME, Moore RJ, Gritsenko MA, Kozany C, Hixson KK, Mottaz HM, Zischka H, Ueffing M, Herman ZS, Davis RW, Meitinger T, Oefner PJ, Smith RD, Steinmetz LM. PLoS Biol. 2004 Jun; 2004 Jun 15. PMID: 15208715.", + "MitoP2, an integrated database on mitochondrial proteins in yeast and man. Andreoli C, Prokisch H, Hörtnagel K, Mueller JC, Münsterkötter M, Scharfe C, Meitinger T. Nucleic Acids Res. 2004 Jan 1. PMID: 14681457.", + "A tRNA(Ala) mutation causing mitochondrial myopathy clinically resembling myotonic dystrophy. Horváth R, Lochmüller H, Scharfe C, Do BH, Oefner PJ, Müller-Höcker J, Schoser BG, Pongratz D, Auer DP, Jaksch M. J Med Genet. 2003 Oct. PMID: 14569122.", + "Role of duplicate genes in genetic robustness against null mutations. Gu Z, Steinmetz LM, Gu X, Scharfe C, Davis RW, Li WH. Nature. 2003 Jan 2. PMID: 12511954.", + "Childhood onset mitochondrial myopathy and lactic acidosis caused by a stop mutation in the mitochondrial cytochrome c oxidase III gene. Horváth R, Scharfe C, Hoeltzenbein M, Do BH, Schröder C, Warzok R, Vogelgesang S, Lochmüller H, Müller-Höcker J, Gerbitz KD, Oefner PJ, Jaksch M. J Med Genet. 2002 Nov. PMID: 12414820.", + "Systematic screen for human disease genes in yeast. Steinmetz LM, Scharfe C, Deutschbauer AM, Mokranjac D, Herman ZS, Jones T, Chu AM, Giaever G, Prokisch H, Oefner PJ, Davis RW. Nat Genet. 2002 Aug; 2002 Jul 22. PMID: 12134146.", + "Evolutionary rate in the protein interaction network. Fraser HB, Hirsh AE, Steinmetz LM, Scharfe C, Feldman MW. Science. 2002 Apr 26. PMID: 11976460.", + "Frequency of mitochondrial transfer RNA mutations and deletions in 225 patients presenting with respiratory chain deficiencies. Jaksch M, Kleinle S, Scharfe C, Klopstock T, Pongratz D, Müller-Höcker J, Gerbitz KD, Liechti-Gallati S, Lochmuller H, Horvath R. J Med Genet. 2001 Oct. PMID: 11584044.", + "The complete form of X-linked congenital stationary night blindness is caused by mutations in a gene encoding a leucine-rich repeat protein. Pusch CM, Zeitz C, Brandau O, Pesch K, Achatz H, Feil S, Scharfe C, Maurer J, Jacobi FK, Pinckers A, Andreasson S, Hardcastle A, Wissinger B, Berger W, Meindl A. Nat Genet. 2000 Nov. PMID: 11062472.", + "A novel mutation in the thiamine responsive megaloblastic anaemia gene SLC19A2 in a patient with deficiency of respiratory chain complex I. Scharfe C, Hauschild M, Klopstock T, Janssen AJ, Heidemann PH, Meitinger T, Jaksch M. J Med Genet. 2000 Sep. PMID: 10978358.", + "MITOP, the mitochondrial proteome database: 2000 update. Scharfe C, Zaccaria P, Hoertnagel K, Jaksch M, Klopstock T, Dembowski M, Lill R, Prokisch H, Gerbitz KD, Neupert W, Mewes HW, Meitinger T. Nucleic Acids Res. 2000 Jan 1. PMID: 10592209.", + "MITOP: database for mitochondria-related proteins, genes and diseases. Scharfe C, Zaccaria P, Hoertnagel K, Jaksch M, Klopstock T, Lill R, Prokisch H, Gerbitz KD, Mewes HW, Meitinger T. Nucleic Acids Res. 1999 Jan 1. PMID: 9847163.", + "Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein. Strom TM, Hörtnagel K, Hofmann S, Gekeler F, Scharfe C, Rabl W, Gerbitz KD, Meitinger T. Hum Mol Genet. 1998 Dec. PMID: 9817917.", + "Report of the second international workshop on human chromosome 10 mapping 1997. Meitinger T, Scharfe C, Call K, Moschonas N. Cytogenet Cell Genet. 1997. PMID: 9465886.", + "Scharfe Lab SHM-I 322 333 Cedar Street New Haven, CT 06520-8005 Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Schiff Lab", + "lab_url": "https://medicine.yale.edu/lab/schiff/", + "research_bio": "INFORMATION FOR Copy Link Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Schlessinger Lab", + "lab_url": "https://medicine.yale.edu/lab/schlessinger/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Schlieker Lab", + "lab_url": "https://medicine.yale.edu/lab/schlieker/", + "research_bio": "INFORMATION FOR Graduation We explore how cells build and safeguard two vital structures — thenuclear envelopeand theendoplasmic reticulum— to ensure protein quality control and cellular homeostasis. Our work focuses on how disruptions in membrane organization andphase separationdrive the formation of aberrant condensates connected to neurological disease. To tackle these questions, we develop and apply new tools that let us probe and modulate these processes across scales. By integratingcell biology, biochemistry, and computational approaches, we aim to uncover fundamental principles of cellular organization and translate these discoveries into novel therapeutic strategies. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/schlieker/publications/", + "publications": [ + "Yale School of Medicine /", + "Molecular Biophysics and Biochemistry /", + "Research", + "Positions", + "Members", + "Photos", + "Publications", + "Contact", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Members", + "Publications", + "Contact", + "Positions", + "Photos", + "", + "", + "", + "", + "", + "", + "Nodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation. Naughton BS, Devarkar SC, Todorow V, Mallik S, Oxendine S, Junnarkar S, Ren Y, Berro J, Kirstein J, Xiong Y, Schlieker C. J Cell Biol. 2025 Sep 1; 2025 Jul 15. PMID: 40663102.", + "Genetically encoded mechano-sensors with versatile readouts and compact size. Ren Y, Yang J, Saito T, Glomb O, Kumar A, Mousavi SI, Naughton B, de Fontnouvelle C, Fujita B, Xi Z, Schlieker C, Yogev S, Zhang Y, Berro J. bioRxiv. 2025 Jul 1; 2025 Jul 1. PMID: 39868242.", + "Integrative Chemical Genetics Platform Identifies Condensate Modulators Linked to Neurological Disorders. Poch D, Mukherjee C, Mallik S, Todorow V, Kuiper EFE, Dhingra N, Surovtseva YV, Schlieker C. bioRxiv. 2025 Jun 8; 2025 Jun 8. PMID: 40502095.", + "Protein folding and quality control during nuclear transport. Mallik S, Poch D, Burick S, Schlieker C. Curr Opin Cell Biol. 2024 Oct; 2024 Aug 13. PMID: 39142062.", + "Coordinating nucleoporin condensation and nuclear pore complex assembly. Kuiper EFE, Prophet SM, Schlieker C. FEBS Lett. 2023 Oct; 2023 Aug 30. PMID: 37620293.", + "Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins. Tsai PL, Cameron CJF, Forni MF, Wasko RR, Naughton BS, Horsley V, Gerstein MB, Schlieker C. Cell Rep. 2022 Nov 22. PMID: 36417855.", + "Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities. Prophet SM, Rampello AJ, Niescier RF, Gentile JE, Mallik S, Koleske AJ, Schlieker C. Nat Cell Biol. 2022 Nov; 2022 Oct 27. PMID: 36302970.", + "Neural network based successor representations to form cognitive maps of space and language. Stoewer P, Schlieker C, Schilling A, Metzner C, Maier A, Krauss P. Sci Rep. 2022 Jul 4; 2022 Jul 4. PMID: 35787659.", + "p97/UBXD1 Generate Ubiquitylated Proteins That Are Sequestered into Nuclear Envelope Herniations in Torsin-Deficient Cells. Prophet SM, Naughton BS, Schlieker C. Int J Mol Sci. 2022 Apr 21; 2022 Apr 21. PMID: 35563018.", + "Nodal modulator (NOMO) is required to sustain endoplasmic reticulum morphology. Amaya C, Cameron CJF, Devarkar SC, Seager SJH, Gerstein MB, Xiong Y, Schlieker C. J Biol Chem. 2021 Aug; 2021 Jul 3. PMID: 34224731.", + "Lipid and protein dynamics that shape nuclear envelope identity. Bahmanyar S, Schlieker C. Mol Biol Cell. 2020 Jun 15. PMID: 32530796.", + "Torsin ATPase deficiency leads to defects in nuclear pore biogenesis and sequestration of MLF2. Rampello AJ, Laudermilch E, Vishnoi N, Prophet SM, Shao L, Zhao C, Lusk CP, Schlieker C. J Cell Biol. 2020 Jun 1. PMID: 32342107.", + "The Role of Torsin AAA+ Proteins in Preserving Nuclear Envelope Integrity and Safeguarding Against Disease. Rampello AJ, Prophet SM, Schlieker C. Biomolecules. 2020 Mar 19; 2020 Mar 19. PMID: 32204310.", + "An unbiased approach de-livers unexpected insight into torsin biology. Prophet SM, Schlieker C. J Clin Invest. 2019 Nov 1. PMID: 31589164.", + "Methodologies to monitor protein turnover at the inner nuclear membrane. Tsai PL, Zhao C, Schlieker C. Methods Enzymol. 2019; 2019 Feb 8. PMID: 30910029.", + "Dynamic functional assembly of the Torsin AAA+ ATPase and its modulation by LAP1. Chase AR, Laudermilch E, Wang J, Shigematsu H, Yokoyama T, Schlieker C. Mol Biol Cell. 2017 Oct 15; 2017 Aug 16. PMID: 28814508.", + "Torsin ATPases: Harnessing Dynamic Instability for Function. Chase AR, Laudermilch E, Schlieker C. Front Mol Biosci. 2017; 2017 May 11. PMID: 28553638.", + "Dissecting Torsin/cofactor function at the nuclear envelope: a genetic study. Laudermilch E, Tsai PL, Graham M, Turner E, Zhao C, Schlieker C. Mol Biol Cell. 2016 Dec 15; 2016 Oct 26. PMID: 27798237.", + "Pelger-Huët anomaly and Greenberg skeletal dysplasia: LBR-associated diseases of cholesterol metabolism. Turner EM, Schlieker C. Rare Dis. 2016; 2016 Sep 27. PMID: 27830109.", + "The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations. Tsai PL, Zhao C, Turner E, Schlieker C. Elife. 2016 Jun 23; 2016 Jun 23. PMID: 27336722.", + "Torsin ATPases: structural insights and functional perspectives. Laudermilch E, Schlieker C. Curr Opin Cell Biol. 2016 Jun; 2016 Jan 21. PMID: 26803745.", + "Site-specific Proteolysis Mobilizes TorsinA from the Membrane of the Endoplasmic Reticulum (ER) in Response to ER Stress and B Cell Stimulation. Zhao C, Brown RS, Tang CH, Hu CC, Schlieker C. J Biol Chem. 2016 Apr 29; 2016 Mar 7. PMID: 26953341.", + "A designed repeat protein as an affinity capture reagent. Speltz EB, Brown RS, Hajare HS, Schlieker C, Regan L. Biochem Soc Trans. 2015 Oct. PMID: 26517897.", + "The Torsin Activator LULL1 Is Required for Efficient Growth of Herpes Simplex Virus 1. Turner EM, Brown RS, Laudermilch E, Tsai PL, Schlieker C. J Virol. 2015 Aug; 2015 Jun 3. PMID: 26041288.", + "Torsins: not your typical AAA+ ATPases. Rose AE, Brown RS, Schlieker C. Crit Rev Biochem Mol Biol. 2015; 2015 Oct 13. PMID: 26592310.", + "The mechanism of Torsin ATPase activation. Brown RS, Zhao C, Chase AR, Wang J, Schlieker C. Proc Natl Acad Sci U S A. 2014 Nov 11; 2014 Oct 28. PMID: 25352667.", + "Arresting a Torsin ATPase reshapes the endoplasmic reticulum. Rose AE, Zhao C, Turner EM, Steyer AM, Schlieker C. J Biol Chem. 2014 Jan 3; 2013 Nov 25. PMID: 24275647.", + "Regulation of Torsin ATPases by LAP1 and LULL1. Zhao C, Brown RS, Chase AR, Eisele MR, Schlieker C. Proc Natl Acad Sci U S A. 2013 Apr 23; 2013 Apr 8. PMID: 23569223.", + "A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation. Sehrawat S, Koenig PA, Kirak O, Schlieker C, Fankhauser M, Ploegh HL. Blood. 2013 Feb 14; 2012 Dec 13. PMID: 23243279.", + "Alternative nuclear transport for cellular protein quality control. Rose A, Schlieker C. Trends Cell Biol. 2012 Oct; 2012 Jul 31. PMID: 22858153.", + "Enzymatic blockade of the ubiquitin-proteasome pathway. Ernst R, Claessen JH, Mueller B, Sanyal S, Spooner E, van der Veen AG, Kirak O, Schlieker CD, Weihofen WA, Ploegh HL. PLoS Biol. 2011 Mar; 2011 Mar 29. PMID: 21468303.", + "Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier. Van der Veen AG, Schorpp K, Schlieker C, Buti L, Damon JR, Spooner E, Ploegh HL, Jentsch S. Proc Natl Acad Sci U S A. 2011 Feb 1; 2011 Jan 5. PMID: 21209336.", + "DNA repair: Blocking ubiquitin transfer. Rose A, Schlieker C. Nature. 2010 Aug 19. PMID: 20725029.", + "The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Ernst R, Mueller B, Ploegh HL, Schlieker C. Mol Cell. 2009 Oct 9. PMID: 19818707.", + "A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. Schlieker CD, Van der Veen AG, Damon JR, Spooner E, Ploegh HL. Proc Natl Acad Sci U S A. 2008 Nov 25; 2008 Nov 18. PMID: 19017811.", + "Mechanisms, biology and inhibitors of deubiquitinating enzymes. Love KR, Catic A, Schlieker C, Ploegh HL. Nat Chem Biol. 2007 Nov. PMID: 17948018.", + "A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection. Gredmark S, Schlieker C, Quesada V, Spooner E, Ploegh HL. J Virol. 2007 Oct; 2007 Jul 18. PMID: 17634221.", + "Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes. Schlieker C, Weihofen WA, Frijns E, Kattenhorn LM, Gaudet R, Ploegh HL. Mol Cell. 2007 Mar 9. PMID: 17349955.", + "A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae. Schlieker C, Korbel GA, Kattenhorn LM, Ploegh HL. J Virol. 2005 Dec. PMID: 16306630.", + "ClpV, a unique Hsp100/Clp member of pathogenic proteobacteria. Schlieker C, Zentgraf H, Dersch P, Mogk A. Biol Chem. 2005 Nov. PMID: 16307477.", + "Novel insights into the mechanism of chaperone-assisted protein disaggregation. Weibezahn J, Schlieker C, Tessarz P, Mogk A, Bukau B. Biol Chem. 2005 Aug. PMID: 16201868.", + "Solubilization of aggregated proteins by ClpB/DnaK relies on the continuous extraction of unfolded polypeptides. Schlieker C, Tews I, Bukau B, Mogk A. FEBS Lett. 2004 Dec 17. PMID: 15589844.", + "Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB. Weibezahn J, Tessarz P, Schlieker C, Zahn R, Maglica Z, Lee S, Zentgraf H, Weber-Ban EU, Dougan DA, Tsai FT, Mogk A, Bukau B. Cell. 2004 Nov 24. PMID: 15550247.", + "Substrate recognition by the AAA+ chaperone ClpB. Schlieker C, Weibezahn J, Patzelt H, Tessarz P, Strub C, Zeth K, Erbse A, Schneider-Mergener J, Chin JW, Schultz PG, Bukau B, Mogk A. Nat Struct Mol Biol. 2004 Jul; 2004 Jun 20. PMID: 15208691.", + "A PDZ switch for a cellular stress response. Schlieker C, Mogk A, Bukau B. Cell. 2004 May 14. PMID: 15137934.", + "Broad yet high substrate specificity: the challenge of AAA+ proteins. Mogk A, Dougan D, Weibezahn J, Schlieker C, Turgay K, Bukau B. J Struct Biol. 2004 Apr-May. PMID: 15037240.", + "Poly-L-lysine enhances the protein disaggregation activity of ClpB. Strub C, Schlieker C, Bukau B, Mogk A. FEBS Lett. 2003 Oct 9. PMID: 14550559.", + "Characterization of a trap mutant of the AAA+ chaperone ClpB. Weibezahn J, Schlieker C, Bukau B, Mogk A. J Biol Chem. 2003 Aug 29; 2003 Jun 12. PMID: 12805357.", + "Refolding of substrates bound to small Hsps relies on a disaggregation reaction mediated most efficiently by ClpB/DnaK. Mogk A, Schlieker C, Friedrich KL, Schönfeld HJ, Vierling E, Bukau B. J Biol Chem. 2003 Aug 15; 2003 Jun 4. PMID: 12788951.", + "Roles of individual domains and conserved motifs of the AAA+ chaperone ClpB in oligomerization, ATP hydrolysis, and chaperone activity. Mogk A, Schlieker C, Strub C, Rist W, Weibezahn J, Bukau B. J Biol Chem. 2003 May 16; 2003 Mar 6. PMID: 12624113.", + "Prevention and reversion of protein aggregation by molecular chaperones in the E. coli cytosol: implications for their applicability in biotechnology. Schlieker C, Bukau B, Mogk A. J Biotechnol. 2002 Jun 13. PMID: 12142139.", + "Bass Center 266 Whitney Avenue New Haven, CT 06511", + "Calendar", + "Contact Us", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Schwartz Lab", + "lab_url": "https://medicine.yale.edu/lab/schwartz/", + "research_bio": "INFORMATION FOR How cells coordinate to form mechanically stable, functional three dimensional tissues and organisms is arguably the most interesting and important problem in 21st century biological sciences. It underlies not just normal development and physiology but also cancer and heart disease, the major killers in developed nations. Our lab studies two critical and related aspects of these problems. They are: integrin signaling, or how cells respond to extracellular matrix; and mechanotransduction, or how cells respond to mechanical forces. We study both fundamental aspects of these processes and their roles in the vascular system, particularly atherosclerosis and other vascular diseases. More broadly, we aim to relate our basic discoveries in cell biology to human disease its treatment. Thus, as befits a basic scientist in the Yale Department of Medicine, our research program brings together tools and approaches from cell biology, biophysics and bioengineering with developmental systems and models of human disease. Talin tension TIRF time lapse. Using the tension sensor technology developed in our lab (see Grashoff, 2010 Nature), we developed a sensor for mechanical tension across the focal adhesion protein talin that links integrins to the actin cytoskeleton (see Kumar 2016 J. Cell Biol.). Imaging was done using total internal reflection (TIRF) optics. Frames taken from a movie show talin FRET ratio (FRET emission/acceptor intensity) demonstrating gradients of tension within single focal adhesions, adhesion formation, sliding and disassembly. Copy Link The Department of Internal Medicine is pleased to welcome the following new staff, faculty, postdoctoral fellows, and postdoctoral associates who joined the team in March 2025. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/schwartz/publications/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Cardiovascular Medicine /", + "Research", + "Contact Us", + "Lab History", + "People", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Lab History", + "People", + "Publications", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Mechanomedicine: Present state and future promise. Wang N, Chien S, Schwartz MA. Proc Natl Acad Sci U S A. 2025 Nov 18; 2025 Nov 11. PMID: 41218111.", + "Elucidation of Marcus Relationships for Hydride Transfer Reactions Involving Transition Metal Hydrides. Kumar A, Ertem MZ, Hazari N, Miller AJM. J Am Chem Soc. 2025 Sep 10; 2025 Aug 25. PMID: 40854557.", + "PIEZO1 Overexpression in Hereditary Hemorrhagic Telangiectasia Arteriovenous Malformations. Park H, Lee S, Furtado J, Robinson M, Antaya RJ, Oh SP, Hong YK, Schwartz MA, Young LH, Eichmann A. Circulation. 2025 Sep 2; 2025 Jul 16. PMID: 40665909.", + "Direct Activity Measurement of Heterotrimeric Gi Proteins and Gq Protein By Effector Pulldown. Tanaka K, Schwartz MA. Bio Protoc. 2025 Aug 5; 2025 Aug 5. PMID: 40799476.", + "Why would anyone want to be a scientist? Schwartz MA. J Cell Sci. 2025 Aug 1; 2025 Aug 1. PMID: 40747557.", + "Photoelectrocatalytic Reduction of CO2 to Formate Using Immobilized Molecular Manganese Catalysts on Oxidized Porous Silicon. Hong YH, Jia X, Stewart-Jones E, Kumar A, Wedal JC, Alvarez-Hernandez JL, Donley CL, Gang A, Gibson NJ, Hazari N, Houck M, Jeon S, Kim J, Koh H, Mayer JM, Mercado BQ, Nedzbala HS, Piekut N, Quist C, Stach E, Zhang Y. Chem. 2025 Jul 10; 2025 Mar 7. PMID: 40894117.", + "Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation. Kumar A, Tanaka K, Schwartz MA. Elife. 2025 Jun 26; 2025 Jun 26. PMID: 40568958.", + "Endothelial heterogeneity shapes shear stress response: a transcriptomic perspective. Deng H. Res Pract Thromb Haemost. 2025 May; 2025 Jun 10. PMID: 40678354.", + "Fluid Shear Stress-Regulated Vascular Remodeling: Past, Present, and Future. Deng H, Eichmann A, Schwartz MA. Arterioscler Thromb Vasc Biol. 2025 Jun; 2025 Apr 10. PMID: 40207366.", + "Early Pre-Emptive Kidney Transplant Does Not Offer Any Mortality Benefits: A Study of Trends in Pre-Emptive Kidney Transplantation Over the Last Two Decades. Kumar A, Bonnell L, Kuppachi S. Transplant Proc. 2025 May; 2025 Mar 25. PMID: 40140312.", + "A Survey for Human Tissue-Level Determinants of CAV1 Regulation and Function. Jiménez-Jiménez V, Sánchez-Cabo F, Schwartz MA, Sánchez-Álvarez M, Del Pozo MÁ. Int J Mol Sci. 2025 Apr 17; 2025 Apr 17. PMID: 40332409.", + "Pushing the Boundaries of Living Donation Through Kidney Paired Donation. Kumar A, Nishio Lucar AG, Doshi MD. Am J Kidney Dis. 2025 Apr; 2024 Dec 18. PMID: 39706246.", + "Short-term disruption of TGF-β signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection. Jiang B, Ren P, He C, Wang M, Murtada SI, Ruiz-Rodríguez MJ, Chen Y, Ramachandra AB, Li G, Qin L, Assi R, Schwartz MA, Humphrey JD, Tellides G. JCI Insight. 2025 Feb 11; 2025 Feb 11. PMID: 39932797.", + "Conformational response of α(IIb)β(3) and α(V)β(3) integrins to force. Kolasangiani R, Farzanian K, Chen Y, Schwartz MA, Bidone TC. Structure. 2025 Feb 6; 2024 Dec 19. PMID: 39706199.", + "IGFBP6 contributes to vascular resilience. Schwartz MA. Nat Cardiovasc Res. 2025 Feb. PMID: 39794480.", + "Comparison of Safety and Efficacy of Aspiration Thrombectomy and Ultrasound Accelerated Thrombolysis for Management of Pulmonary Embolism: A Systematic Review and Meta-Analysis. Choksi EJ, Sare A, Shukla PA, Kumar A. Vasc Endovascular Surg. 2025 Feb; 2024 Oct 4. PMID: 39365670.", + "cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling. Deng H, Rukhlenko OS, Joshi D, Hu X, Junk P, Tuliakova A, Kholodenko BN, Schwartz MA. Sci Adv. 2025 Jan 3; 2025 Jan 3. PMID: 39752487.", + "DNA nanodevice for analysis of force-activated protein extension and interactions. Zhou K, Chung M, Cheng J, Powell JT, Yan Q, Liu J, Xiong Y, Schwartz MA, Lin C. bioRxiv. 2024 Dec 11; 2024 Dec 11. PMID: 39554144.", + "Polycomb Repressive Complex 2 promotes atherosclerotic plaque vulnerability. Joshi D, Chakraborty R, Bhogale T, Furtado J, Deng H, Traylor JG Jr, Orr AW, Martin KA, Schwartz MA. bioRxiv. 2024 Dec 2; 2024 Dec 2. PMID: 39703699.", + "Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation. Kumar A, Tanaka K, Schwartz MA. bioRxiv. 2024 Nov 14; 2024 Nov 14. PMID: 38045367.", + "Linear Free Energy Relationships Associated with Hydride Transfer From [(6,6'-R(2)-bpy)Re(CO)(3)H]: A Cautionary Tale in Identifying Hydrogen Bonding Effects in the Secondary Coordination Sphere. Elsby MR, Kumar A, Daniels LM, Ertem MZ, Hazari N, Mercado BQ, Paulus AH. Inorg Chem. 2024 Oct 14; 2024 Sep 30. PMID: 39344157.", + "DNA-Based Molecular Clamp for Probing Protein Interactions and Structure under Force. Chung M, Zhou K, Powell JT, Lin C, Schwartz MA. ACS Nano. 2024 Oct 8; 2024 Sep 29. PMID: 39344156.", + "Endothelial γ-protocadherins inhibit KLF2 and KLF4 to promote atherosclerosis. Joshi D, Coon BG, Chakraborty R, Deng H, Yang Z, Babar MU, Fernandez-Tussy P, Meredith E, Attanasio J, Joshi N, Traylor JG Jr, Orr AW, Fernandez-Hernando C, Libreros S, Schwartz MA. Nat Cardiovasc Res. 2024 Sep; 2024 Sep 4. PMID: 39232138.", + "Controversy in mechanotransduction - the role of endothelial cell-cell junctions in fluid shear stress sensing. X S, Aitken C, Mehta V, Tardajos-Ayllon B, Serbanovic-Canic J, Zhu J, Miao B, Tzima E, Evans P, Fang Y, Schwartz MA. J Cell Sci. 2024 Sep 1; 2024 Sep 9. PMID: 39143856.", + "Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis. Chanduri M, Kumar A, Weiss D, Emuna N, Barsukov I, Shi M, Tanaka K, Wang X, Datye A, Kanyo J, Collin F, Lam T, Schwarz UD, Bai S, Nottoli T, Goult BT, Humphrey JD, Schwartz MA. Sci Adv. 2024 Aug 23; 2024 Aug 21. PMID: 39167642.", + "Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions. Tanaka K, Chen M, Prendergast A, Zhuang Z, Nasiri A, Joshi D, Hintzen J, Chung M, Kumar A, Mani A, Koleske A, Crawford J, Nicoli S, Schwartz MA. EMBO J. 2024 Aug; 2024 Jun 17. PMID: 38886581.", + "A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling. Deng H, Zhang J, Wang Y, Joshi D, Pi X, De Val S, Schwartz MA. Nat Cardiovasc Res. 2024 Jul; 2024 Jul 8. PMID: 39196179.", + "A DNA-based molecular clamp for probing protein interactions and structure under force. Chung M, Zhou K, Powell J, Lin C, Schwartz MA. bioRxiv. 2024 Jun 6; 2024 Jun 6. PMID: 38895381.", + "Integrins as Drug Targets in Vascular and Related Diseases. Meredith E, Schwartz MA. Int J Drug Discov Pharm. 2024 Jun; 2024 Jun 21. PMID: 39703402.", + "Afadin-nectin forces its way to the front. Sebbagh M, Schwartz MA. J Cell Biol. 2024 May 6; 2024 Apr 2. PMID: 38563860.", + "Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities. Stroope C, Nettersheim FS, Coon B, Finney AC, Schwartz MA, Ley K, Rom O, Yurdagul A Jr. Nat Metab. 2024 Apr; 2024 Mar 26. PMID: 38532071.", + "Calcium flow at ER-TGN contact sites facilitates secretory cargo export. Ramazanov BR, Parchure A, Di Martino R, Kumar A, Chung M, Kim Y, Griesbeck O, Schwartz MA, Luini A, von Blume J. Mol Biol Cell. 2024 Apr 1; 2024 Jan 31. PMID: 38294859.", + "Kidney after Liver Transplantation for All: Are You Kidneying Me? Kumar A, Wadei HM. Clin J Am Soc Nephrol. 2024 Mar 1; 2024 Jan 24. PMID: 38265809.", + "A large-scale retrospective study enabled deep-learning based pathological assessment of frozen procurement kidney biopsies to predict graft loss and guide organ utilization. Yi Z, Xi C, Menon MC, Cravedi P, Tedla F, Soto A, Sun Z, Liu K, Zhang J, Wei C, Chen M, Wang W, Veremis B, Garcia-Barros M, Kumar A, Haakinson D, Brody R, Azeloglu EU, Gallon L, O'Connell P, Naesens M, Shapiro R, Colvin RB, Ward S, Salem F, Zhang W. Kidney Int. 2024 Feb; 2023 Nov 3. PMID: 37923131.", + "Gamma protocadherins in vascular endothelial cells inhibit Klf2/4 to promote atherosclerosis. Joshi D, Coon BG, Chakraborty R, Deng H, Fernandez-Tussy P, Meredith E, Traylor JG Jr, Orr AW, Fernandez-Hernando C, Schwartz MA. bioRxiv. 2024 Jan 21; 2024 Jan 21. PMID: 38293157.", + "Dynamic metabolism of endothelial triglycerides protects against atherosclerosis in mice. Boutagy NE, Gamez-Mendez A, Fowler JW, Zhang H, Chaube BK, Esplugues E, Kuo A, Lee S, Horikami D, Zhang J, Citrin KM, Singh AK, Coon BG, Lee MY, Suarez Y, Fernandez-Hernando C, Sessa WC. J Clin Invest. 2024 Jan 4; 2024 Jan 4. PMID: 38175710.", + "Intracellular tension sensor reveals mechanical anisotropy of the actin cytoskeleton. Amiri S, Muresan C, Shang X, Huet-Calderwood C, Schwartz MA, Calderwood DA, Murrell M. Nat Commun. 2023 Dec 4; 2023 Dec 4. PMID: 38049429.", + "Report from the 2023 workshop on endothelial permeability, edema and inflammation. Vestweber D, Claesson-Welsh L, McDonald DM, Williams T, Schwartz MA, Scallan J, Gavins FNE, van Buul J, Gamble J, Vadas M, Annex BH, Messe SR, Perretti M, André H, Ferrara N, Hla T, Nourshargh S, Simons M. Nat Cardiovasc Res. 2023 Dec. PMID: 39196154.", + "SMAD4 maintains the fluid shear stress set point to protect against arterial-venous malformations. Banerjee K, Lin Y, Gahn J, Cordero J, Gupta P, Mohamed I, Graupera M, Dobreva G, Schwartz MA, Ola R. J Clin Invest. 2023 Sep 15; 2023 Sep 15. PMID: 37490341.", + "The importance of character development in scientific research. Schwartz MA, Yap AS. J Cell Sci. 2023 Jul 1; 2023 Jul 5. PMID: 37403645.", + "Altered Integrin Signaling in Thoracic Aortopathy. Humphrey JD, Schwartz MA. Arterioscler Thromb Vasc Biol. 2023 Jul; 2023 May 11. PMID: 37165879.", + "Mechanisms of endothelial flow sensing. Aitken C, Mehta V, Schwartz MA, Tzima E. Nat Cardiovasc Res. 2023 Jun; 2023 Jun 12. PMID: 39195881.", + "FN (Fibronectin)-Integrin α5 Signaling Promotes Thoracic Aortic Aneurysm in a Mouse Model of Marfan Syndrome. Chen M, Cavinato C, Hansen J, Tanaka K, Ren P, Hassab A, Li DS, Youshao E, Tellides G, Iyengar R, Humphrey JD, Schwartz MA. Arterioscler Thromb Vasc Biol. 2023 May; 2023 Mar 30. PMID: 36994727.", + "TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity. Gallego-Paez LM, Edwards WJS, Chanduri M, Guo Y, Koorman T, Lee CY, Grexa N, Derksen P, Yan J, Schwartz MA, Mauer J, Goult BT. J Cell Biol. 2023 May 1; 2023 Mar 6. PMID: 36880935.", + "Dynamic antagonism between key repressive pathways maintains the placental epigenome. Weigert R, Hetzel S, Bailly N, Haggerty C, Ilik IA, Yung PYK, Navarro C, Bolondi A, Kumar AS, Anania C, Brändl B, Meierhofer D, Lupiáñez DG, Müller FJ, Aktas T, Elsässer SJ, Kretzmer H, Smith ZD, Meissner A. Nat Cell Biol. 2023 Apr; 2023 Apr 6. PMID: 37024684.", + "Severely Reduced Kidney Function Assessed by a Single eGFR Determination at the Time of an Isolated Heart Transplant Does Not Predict Inevitable Posttransplant ESKD. Kumar A, Bonnell LN, Thomas CP. Transplantation. 2023 Apr 1; 2022 Oct 14. PMID: 36223634.", + "Integrin α(IIb)β(3) intermediates: From molecular dynamics to adhesion assembly. Tong D, Soley N, Kolasangiani R, Schwartz MA, Bidone TC. Biophys J. 2023 Feb 7; 2022 Dec 23. PMID: 36566352.", + "Endothelial mechanosensing: A forgotten target to treat vascular remodeling in hypertension? Tiezzi M, Deng H, Baeyens N. Biochem Pharmacol. 2022 Dec; 2022 Oct 12. PMID: 36241094.", + "Integrin Conformational Dynamics and Mechanotransduction. Kolasangiani R, Bidone TC, Schwartz MA. Cells. 2022 Nov 12; 2022 Nov 12. PMID: 36429013.", + "The Transplant Kidney Biopsy: In Whose Hands? Virmani S, Kumar A. Kidney360. 2022 Oct 27; 2022 Oct 27. PMID: 36514728.", + "The U-shaped association of post-lung transplant mortality with pretransplant eGFR underscores possible limitations of creatinine-based estimation equations for risk stratification. Kumar A, Bonnell LN, Eberlein M, Thomas CP. J Heart Lung Transplant. 2022 Sep; 2022 Jun 4. PMID: 35778259.", + "Fibronectin-Integrin α5 Signaling in Vascular Complications of Type 1 Diabetes. Chen M, Hu R, Cavinato C, Zhuang ZW, Zhang J, Yun S, Fernandez Tussy P, Singh A, Murtada SI, Tanaka K, Liu M, Fernández-Hernando C, Humphrey JD, Schwartz MA. Diabetes. 2022 Sep 1. PMID: 35771994.", + "The UIP/IPF fibroblastic focus is a collagen biosynthesis factory embedded in a distinct extracellular matrix. Herrera JA, Dingle L, Montero MA, Venkateswaran RV, Blaikley JF, Lawless C, Schwartz MA. JCI Insight. 2022 Aug 22; 2022 Aug 22. PMID: 35852874.", + "MicroRNAs in Mechanical Homeostasis. Herrera JA, Schwartz MA. Cold Spring Harb Perspect Med. 2022 Aug 15; 2022 Aug 15. PMID: 35379658.", + "High Fluid Shear Stress Inhibits Cytokine-Driven Smad2/3 Activation in Vascular Endothelial Cells. Deng H, Schwartz MA. J Am Heart Assoc. 2022 Jul 19; 2022 Jul 15. PMID: 35861829.", + "A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cells. Coon BG, Timalsina S, Astone M, Zhuang ZW, Fang J, Han J, Themen J, Chung M, Yang-Klingler YJ, Jain M, Hirschi KK, Yamamato A, Trudeau LE, Santoro M, Schwartz MA. J Cell Biol. 2022 Jul 4; 2022 Jun 13. PMID: 35695893.", + "The evolution of performing a kidney biopsy: a single center experience comparing native and transplant kidney biopsies performed by interventional radiologists and nephrologists. Emelianova D, Prikis M, Morris CS, Gibson PC, Solomon R, Scriver G, Smith ZT, Bhave A, Shields J, DeSarno M, Kumar A. BMC Nephrol. 2022 Jun 25; 2022 Jun 25. PMID: 35752759.", + "mTOR inhibition prevents angiotensin II-induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice. He C, Jiang B, Wang M, Ren P, Murtada SI, Caulk AW, Li G, Qin L, Assi R, Lovoulos CJ, Schwartz MA, Humphrey JD, Tellides G. JCI Insight. 2022 Feb 8; 2022 Feb 8. PMID: 35132962.", + "MEKK3-TGFβ crosstalk regulates inward arterial remodeling. Deng H, Xu Y, Hu X, Zhuang ZW, Chang Y, Wang Y, Ntokou A, Schwartz MA, Su B, Simons M. Proc Natl Acad Sci U S A. 2021 Dec 21. PMID: 34911761.", + "Progressive Microstructural Deterioration Dictates Evolving Biomechanical Dysfunction in the Marfan Aorta. Cavinato C, Chen M, Weiss D, Ruiz-Rodríguez MJ, Schwartz MA, Humphrey JD. Front Cardiovasc Med. 2021; 2021 Dec 16. PMID: 34977201.", + "Integrin-based mechanosensing through conformational deformation. Driscoll TP, Bidone TC, Ahn SJ, Yu A, Groisman A, Voth GA, Schwartz MA. Biophys J. 2021 Oct 19; 2021 Sep 10. PMID: 34509509.", + "Talin in mechanotransduction and mechanomemory at a glance. Goult BT, Brown NH, Schwartz MA. J Cell Sci. 2021 Oct 15; 2021 Oct 28. PMID: 34708856.", + "Epistatic interaction of PDE4DIP and DES mutations in familial atrial fibrillation with slow conduction. Abou Ziki MD, Bhat N, Neogi A, Driscoll TP, Ugwu N, Liu Y, Smith E, Abboud JM, Chouairi S, Schwartz MA, Akar JG, Mani A. Hum Mutat. 2021 Oct; 2021 Jul 29. PMID: 34289528.", + "Activation of Smad2/3 signaling by low fluid shear stress mediates artery inward remodeling. Deng H, Min E, Baeyens N, Coon BG, Hu R, Zhuang ZW, Chen M, Huang B, Afolabi T, Zarkada G, Acheampong A, McEntee K, Eichmann A, Liu F, Su B, Simons M, Schwartz MA. Proc Natl Acad Sci U S A. 2021 Sep 14. PMID: 34504019.", + "Fibronectin-Mediated Inflammatory Signaling Through Integrin α5 in Vascular Remodeling. Budatha M, Zhang J, Schwartz MA. J Am Heart Assoc. 2021 Sep 7; 2021 Sep 2. PMID: 34472370.", + "Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. Park H, Furtado J, Poulet M, Chung M, Yun S, Lee S, Sessa WC, Franco CA, Schwartz MA, Eichmann A. Circulation. 2021 Sep 7; 2021 Jun 29. PMID: 34182767.", + "Vascular Mechanobiology: Homeostasis, Adaptation, and Disease. Humphrey JD, Schwartz MA. Annu Rev Biomed Eng. 2021 Jul 13. PMID: 34255994.", + "Altered endocytosis in cellular senescence. Shin EY, Soung NK, Schwartz MA, Kim EG. Ageing Res Rev. 2021 Jul; 2021 Mar 19. PMID: 33753287.", + "Developmental Perspectives on Arterial Fate Specification. Chen D, Schwartz MA, Simons M. Front Cell Dev Biol. 2021; 2021 Jun 25. PMID: 34249941.", + "Early events in endothelial flow sensing. Tanaka K, Joshi D, Timalsina S, Schwartz MA. Cytoskeleton (Hoboken). 2021 Jun; 2021 Feb 15. PMID: 33543538.", + "Developmental origins of mechanical homeostasis in the aorta. Murtada SI, Kawamura Y, Li G, Schwartz MA, Tellides G, Humphrey JD. Dev Dyn. 2021 May; 2021 Jan 4. PMID: 33341996.", + "Structural and developmental principles of neuropil assembly in C. elegans. Moyle MW, Barnes KM, Kuchroo M, Gonopolskiy A, Duncan LH, Sengupta T, Shao L, Guo M, Santella A, Christensen R, Kumar A, Wu Y, Moon KR, Wolf G, Krishnaswamy S, Bao Z, Shroff H, Mohler WA, Colón-Ramos DA. Nature. 2021 Mar; 2021 Feb 24. PMID: 33627875.", + "Actin flow-dependent and -independent force transmission through integrins. Driscoll TP, Ahn SJ, Huang B, Kumar A, Schwartz MA. Proc Natl Acad Sci U S A. 2020 Dec 22; 2020 Dec 1. PMID: 33262280.", + "Integrin-mediated adhesions in regulation of cellular senescence. Shin EY, Park JH, You ST, Lee CS, Won SY, Park JJ, Kim HB, Shim J, Soung NK, Lee OJ, Schwartz MA, Kim EG. Sci Adv. 2020 May; 2020 May 6. PMID: 32494696.", + "Endothelial-to-Mesenchymal Transition, Vascular Inflammation, and Atherosclerosis. Chen PY, Schwartz MA, Simons M. Front Cardiovasc Med. 2020; 2020 May 5. PMID: 32478094.", + "Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity. Solis AG, Bielecki P, Steach HR, Sharma L, Harman CCD, Yun S, de Zoete MR, Warnock JN, To SDF, York AG, Mack M, Schwartz MA, Cruz CSD, Palm NW, Jackson R, Flavell RA. Nature. 2019 Nov. PMID: 31712625.", + "Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone NA, Kauffman KJ, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson DG, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz MA, Pober JS, Chittenden TW, Tellides G, Simons M. Nat Metab. 2019 Sep; 2019 Aug 26. PMID: 31572976.", + "Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity. Solis AG, Bielecki P, Steach HR, Sharma L, Harman CCD, Yun S, de Zoete MR, Warnock JN, To SDF, York AG, Mack M, Schwartz MA, Dela Cruz CS, Palm NW, Jackson R, Flavell RA. Nature. 2019 Sep; 2019 Aug 21. PMID: 31435009.", + "Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis. Yun S, Hu R, Schwaemmle ME, Scherer AN, Zhuang Z, Koleske AJ, Pallas DC, Schwartz MA. J Clin Invest. 2019 Aug 13; 2019 Aug 13. PMID: 31408443.", + "Filamin A mediates isotropic distribution of applied force across the actin network. Kumar A, Shutova MS, Tanaka K, Iwamoto DV, Calderwood DA, Svitkina TM, Schwartz MA. J Cell Biol. 2019 Aug 5; 2019 Jul 17. PMID: 31315944.", + "Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation. Ramírez CM, Zhang X, Bandyopadhyay C, Rotllan N, Sugiyama MG, Aryal B, Liu X, He S, Kraehling JR, Ulrich V, Lin CS, Velazquez H, Lasunción MA, Li G, Suárez Y, Tellides G, Swirski FK, Lee WL, Schwartz MA, Sessa WC, Fernández-Hernando C. Circulation. 2019 Jul 16; 2019 Jun 3. PMID: 31154825.", + "Isotropic Light-Sheet Microscopy and Automated Cell Lineage Analyses to Catalogue Caenorhabditis elegans Embryogenesis with Subcellular Resolution. Duncan LH, Moyle MW, Shao L, Sengupta T, Ikegami R, Kumar A, Guo M, Christensen R, Santella A, Bao Z, Shroff H, Mohler W, Colón-Ramos DA. J Vis Exp. 2019 Jun 6; 2019 Jun 6. PMID: 31233035.", + "MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation. Hu X, Liu ZZ, Chen X, Schulz VP, Kumar A, Hartman AA, Weinstein J, Johnston JF, Rodriguez EC, Eastman AE, Cheng J, Min L, Zhong M, Carroll C, Gallagher PG, Lu J, Schwartz M, King MC, Krause DS, Guo S. Nat Commun. 2019 Apr 12; 2019 Apr 12. PMID: 30979898.", + "Coarse-Grained Simulation of Full-Length Integrin Activation. Bidone TC, Polley A, Jin J, Driscoll T, Iwamoto DV, Calderwood DA, Schwartz MA, Voth GA. Biophys J. 2019 Mar 19; 2019 Feb 22. PMID: 30851876.", + "Translocating transcription factors in fluid shear stress-mediated vascular remodeling and disease. Min E, Schwartz MA. Exp Cell Res. 2019 Mar 1; 2019 Jan 8. PMID: 30633880.", + "ARHGAP18: A Flow-Responsive Gene That Regulates Endothelial Cell Alignment and Protects Against Atherosclerosis. Lay AJ, Coleman PR, Formaz-Preston A, Ting KK, Roediger B, Weninger W, Schwartz MA, Vadas MA, Gamble JR. J Am Heart Assoc. 2019 Jan 22. PMID: 30630384.", + "Vinculin and the mechanical response of adherent fibroblasts to matrix deformation. Rosowski KA, Boltyanskiy R, Xiang Y, Van den Dries K, Schwartz MA, Dufresne ER. Sci Rep. 2018 Dec 19; 2018 Dec 19. PMID: 30568231.", + "Talin as a mechanosensitive signaling hub. Goult BT, Yan J, Schwartz MA. J Cell Biol. 2018 Nov 5; 2018 Sep 25. PMID: 30254032.", + "Local Tension on Talin in Focal Adhesions Correlates with F-Actin Alignment at the Nanometer Scale. Kumar A, Anderson KL, Swift MF, Hanein D, Volkmann N, Schwartz MA. Biophys J. 2018 Oct 16; 2018 Sep 10. PMID: 30274833.", + "hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axis. Di Modugno F, Spada S, Palermo B, Visca P, Iapicca P, Di Carlo A, Antoniani B, Sperduti I, Di Benedetto A, Terrenato I, Mottolese M, Gandolfi F, Facciolo F, Chen EI, Schwartz MA, Santoni A, Bissell MJ, Nisticò P. Oncogene. 2018 Oct; 2018 Jun 15. PMID: 29907768.", + "Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy. Liao X, Shen Y, Zhang R, Sugi K, Vasudevan NT, Alaiti MA, Sweet DR, Zhou L, Qing Y, Gerson SL, Fu C, Wynshaw-Boris A, Hu R, Schwartz MA, Fujioka H, Richardson B, Cameron MJ, Hayashi H, Stamler JS, Jain MK. Proc Natl Acad Sci U S A. 2018 May 15; 2018 Apr 30. PMID: 29712858.", + "A unifying concept in vascular health and disease. Schwartz MA, Vestweber D, Simons M. Science. 2018 Apr 20. PMID: 29674582.", + "Addendum: Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification. Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK. Nat Commun. 2018 Feb 14; 2018 Feb 14. PMID: 29445140.", + "Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis. Budatha M, Zhang J, Zhuang ZW, Yun S, Dahlman JE, Anderson DG, Schwartz MA. J Am Heart Assoc. 2018 Jan 30; 2018 Jan 30. PMID: 29382667.", + "Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification. Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK. Nat Commun. 2017 Dec 15; 2017 Dec 15. PMID: 29247167.", + "Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish. Lagendijk AK, Gomez GA, Baek S, Hesselson D, Hughes WE, Paterson S, Conway DE, Belting HG, Affolter M, Smith KA, Schwartz MA, Yap AS, Hogan BM. Nat Commun. 2017 Nov 10; 2017 Nov 10. PMID: 29123087.", + "VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN. Conway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA. Curr Biol. 2017 Jul 24; 2017 Jul 14. PMID: 28712573.", + "Visualizing Calcium Flux in Freely Moving Nematode Embryos. Ardiel EL, Kumar A, Marbach J, Christensen R, Gupta R, Duncan W, Daniels JS, Stuurman N, Colón-Ramos D, Shroff H. Biophys J. 2017 May 9. PMID: 28494967.", + "Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development. Wang Y, Baeyens N, Corti F, Tanaka K, Fang JS, Zhang J, Jin Y, Coon B, Hirschi KK, Schwartz MA, Simons M. Development. 2016 Dec 1; 2016 Oct 27. PMID: 27789626.", + "Dynamic interaction between actin and nesprin2 maintain the cell nucleus in a prestressed state. Kumar A, Shivashankar GV. Methods Appl Fluoresc. 2016 Nov 11; 2016 Nov 11. PMID: 28192301.", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Sefik Lab", + "lab_url": "https://medicine.yale.edu/lab/sefik/", + "research_bio": "INFORMATION FOR At the Sefik Laboratory, we model and mechanistically study human infectious, inflammatory, fibrotic diseases, and cancer. We combine in vitro and in vivo models, bioinformatic approaches, and perturbation studies in humanized mice to examine the role of various human immune cells in disease pathophysiology. Learn more about our current studies that model and mechanistically examine human infectious, inflammatory, fibrotic diseases, and cancer. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/sefik/publications", + "publications": null + }, + { + "lab_name": "Sestan Lab", + "lab_url": "https://medicine.yale.edu/lab/sestan/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/sestan/publications/", + "publications": [ + "Yale School of Medicine /", + "Neuroscience /", + "Research", + "Contact", + "People", + "Publications", + "Resources", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "Resources", + "Contact", + "", + "", + "", + "", + "", + "", + "Unique and divergent features of human brain development. Salamon I, Doyle DZ, Bandler RC, Pattabiraman K, Sestan N. Curr Opin Neurobiol. 2025 Nov 3; 2025 Nov 3. PMID: 41187489.", + "Spatial dynamics of brain development and neuroinflammation. Zhang D, Rubio Rodríguez-Kirby LA, Lin Y, Wang W, Song M, Wang L, Wang L, Kanatani S, Jimenez-Beristain T, Dang Y, Zhong M, Kukanja P, Bao S, Wang S, Chen XL, Gao F, Wang D, Xu H, Ma C, Lou X, Liu Y, Chen J, Sestan N, Uhlén P, Kriegstein A, Zhao H, Castelo-Branco G, Fan R. Nature. 2025 Nov; 2025 Nov 5. PMID: 41193846.", + "The new frontier in understanding human and mammalian brain development. Nowakowski TJ, Nano PR, Matho KS, Chen X, Corrigan EK, Ding W, Gao Y, Heffel M, Jayakumar J, Kaplan HS, Kronman FN, Kovner R, Mannens CCA, Song M, Steyert MR, Venkatesan S, Wallace JL, Wang L, Werner JM, Zhang D, Yuan G, Zuo G, Ament SA, Colantuoni C, Dulac C, Fan R, Gillis J, Kriegstein AR, Krienen FM, Kim Y, Linnarsson S, Mitra PP, Pollen AA, Sestan N, Tward DJ, van Velthoven CTJ, Yao Z, Bhaduri A, Zeng H. Nature. 2025 Nov; 2025 Nov 5. PMID: 41193845.", + "Human-specific features of the cerebellum and ZP2-regulated synapse development. Kim SK, Cherskov A, Sindhwani A, Choi SH, Kim H, Li ML, Zhang M, Mato-Blanco X, Liu Y, Micali N, Young DM, Estacion M, Zhang Y, Ruiz-Jiménez JM, Nadkarni A, Luria V, Sindhu SK, Chatterjee I, Shibata A, Liang D, Cho H, Park S, Spajic A, Kovner R, Glavan M, Chen RJ, Risgaard RD, Li X, Pochareddy S, Karger A, Huttner A, Morozov YM, Daadi EW, Colantuoni C, Gobeske KT, Ely JJ, Hof PR, Daadi MM, Sherwood CC, Duque A, Ma S, Sousa AMM, Waxman SG, Rakic P, Santpere G, Sanders SJ, Sestan N. bioRxiv. 2025 Sep 9; 2025 Sep 9. PMID: 40964325.", + "Spatial transcriptomics reveals human cortical layer and area specification. Qian X, Coleman K, Jiang S, Kriz AJ, Marciano JH, Luo C, Cai C, Manam MD, Caglayan E, Lai A, Exposito-Alonso D, Otani A, Ghosh U, Shao DD, Andersen RE, Neil JE, Johnson R, LeFevre A, Hecht JL, Micali N, Sestan N, Rakic P, Miller MB, Sun L, Stringer C, Li M, Walsh CA. Nature. 2025 Aug; 2025 May 14. PMID: 40369074.", + "Early developmental origins of cortical disorders modeled in human neural stem cells. Mato-Blanco X, Kim SK, Jourdon A, Ma S, Choi SH, Giani AM, Paredes MI, Tebbenkamp ATN, Liu F, Duque A, Vaccarino FM, Sestan N, Colantuoni C, Rakic P, Santpere G, Micali N. Nat Commun. 2025 Jul 9; 2025 Jul 9. PMID: 40634286.", + "Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques. Joyce MKP, Ivanov TG, Krienen FM, Mitchell JF, Ma S, Inoue W, Nandy AS, Datta D, Duque A, Arellano JI, Gupta R, Gonzalez-Burgos G, Lewis DA, Sestan N, McCarroll SA, Martinez-Trujillo J, Froudist-Walsh S, Arnsten AFT. Commun Biol. 2025 Jul 1; 2025 Jul 1. PMID: 40594842.", + "Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD. Hwang A, Skarica M, Xu S, Coudriet J, Lee CY, Lin L, Terwilliger R, Sliby AN, Wang J, Nguyen T, Li H, Wu M, Dai Y, Duan Z, Srinivasan SS, Zhang X, Lin Y, Cruz D, Deans PJM, Huber BR, Levey D, Glausier JR, Lewis DA, Gelernter J, Holtzheimer PE, Friedman MJ, Gerstein M, Sestan N, Brennand KJ, Xu K, Zhao H, Krystal JH, Young KA, Williamson DE, Che A, Zhang J, Girgenti MJ. Nature. 2025 Jul; 2025 Jun 18. PMID: 40533550.", + "Competing Programs Shape Cortical Sensorimotor-Association Axis Development. Tsyporin J, Zhang M, Qi C, Segal A, Finn T, Kim H, Choi SH, Li X, Bandiera S, Pavlovic I, Kim SK, Shibata A, Onishi K, Zhang Z, Hammarlund E, Su G, Salla N, Kachko J, Hawley C, Li S, Doyle DZ, Peng X, Nottoli T, Ruiz-Reig N, Tissir F, Nakagawa Y, Herzog E, Ma S, Gobeske K, Pattabiraman K, Shimogori T, Duque A, Fornito A, Huang H, Shibata M, Chen B, Sestan N. bioRxiv. 2025 Jun 27; 2025 Jun 27. PMID: 40666864.", + "Decoding human brain evolution: Insights from genomics. Liu Y, Li M, Segal A, Zhang M, Sestan N. Curr Opin Neurobiol. 2025 Jun; 2025 May 6. PMID: 40334295.", + "The Effectiveness of Intervention to Reduce Blood-Borne Pathogen Exposure Incidents in Healthcare Workers in the Largest Clinical Setting in Slovenia. Šestan N, Zaletel-Kragelj L, Franko A. Zdr Varst. 2025 Jun; 2025 Feb 28. PMID: 40099104.", + "Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons. Li Z, Kaur N, Santpere G, Muchnik SK, Sindhu SK, Qi C, Shibata M, Clément O, Klarić TS, de Martin X, Luria V, Cho H, Li M, Shibata A, Tebbenkamp ATN, Ma S, Han W, Kim SK, Pochareddy S, Duy PQ, Xing X, Bao Y, Xu X, Gladwyn-Ng IE, Cullen HD, Paolino A, Fenlon LR, Kozulin P, Suárez R, Risgaard RD, Gulden FO, Karger A, Suzuki IK, Hirata T, Gobeske KT, Richards LJ, Sousa AMM, Heng JI, Sestan N. bioRxiv. 2025 May 21; 2025 May 21. PMID: 40475427.", + "Specification of claustro-amygdalar and palaeocortical neurons and circuits. Kaur N, Kovner R, Gulden FO, Pletikos M, Andrijevic D, Zhu T, Silbereis J, Shibata M, Shibata A, Liu Y, Ma S, Salla N, de Martin X, Klarić TS, Burke M, Franjic D, Cho H, Yuen M, Chatterjee I, Soric P, Esakkimuthu D, Moser M, Santpere G, Mineur YS, Pattabiraman K, Picciotto MR, Huang H, Sestan N. Nature. 2025 Feb; 2025 Jan 15. PMID: 39814878.", + "Dysregulation of mTOR signalling is a converging mechanism in lissencephaly. Zhang C, Liang D, Ercan-Sencicek AG, Bulut AS, Cortes J, Cheng IQ, Henegariu O, Nishimura S, Wang X, Peksen AB, Takeo Y, Caglar C, Lam TT, Koroglu MN, Narayanan A, Lopez-Giraldez F, Miyagishima DF, Mishra-Gorur K, Barak T, Yasuno K, Erson-Omay EZ, Yalcinkaya C, Wang G, Mane S, Kaymakcalan H, Guzel A, Caglayan AO, Tuysuz B, Sestan N, Gunel M, Louvi A, Bilguvar K. Nature. 2025 Feb; 2025 Jan 1. PMID: 39743596.", + "The single-cell opioid responses in the context of HIV (SCORCH) consortium. Ament SA, Campbell RR, Lobo MK, Receveur JP, Agrawal K, Borjabad A, Byrareddy SN, Chang L, Clarke D, Emani P, Gabuzda D, Gaulton KJ, Giglio M, Giorgi FM, Gok B, Guda C, Hadas E, Herb BR, Hu W, Huttner A, Ishmam MR, Jacobs MM, Kelschenbach J, Kim DW, Lee C, Liu S, Liu X, Madras BK, Mahurkar AA, Mash DC, Mukamel EA, Niu M, O'Connor RM, Pagan CM, Pang APS, Pillai P, Repunte-Canonigo V, Ruzicka WB, Stanley J, Tickle T, Tsai SA, Wang A, Wills L, Wilson AM, Wright SN, Xu S, Yang J, Zand M, Zhang L, Zhang J, Akbarian S, Buch S, Cheng CS, Corley MJ, Fox HS, Gerstein M, Gummuluru S, Heiman M, Ho YC, Kellis M, Kenny PJ, Kluger Y, Milner TA, Moore DJ, Morgello S, Ndhlovu LC, Rana TM, Sanna PP, Satterlee JS, Sestan N, Spector SA, Spudich S, Tilgner HU, Volsky DJ, White OR, Williams DW, Zeng H. Mol Psychiatry. 2024 Dec; 2024 Jun 15. PMID: 38879719.", + "Functional associations of evolutionarily recent human genes exhibit sensitivity to the 3D genome landscape and disease. Fleck K, Luria V, Garag N, Karger A, Hunter T, Marten D, Phu W, Nam KM, Sestan N, O'Donnell-Luria AH, Erceg J. bioRxiv. 2024 Nov 22; 2024 Nov 22. PMID: 38559085.", + "Individual variation in the emergence of anterior-to-posterior neural fates from human pluripotent stem cells. Kim SK, Seo S, Stein-O'Brien G, Jaishankar A, Ogawa K, Micali N, Luria V, Karger A, Wang Y, Kim H, Hyde TM, Kleinman JE, Voss T, Fertig EJ, Shin JH, Bürli R, Cross AJ, Brandon NJ, Weinberger DR, Chenoweth JG, Hoeppner DJ, Sestan N, Colantuoni C, McKay RD. Stem Cell Reports. 2024 Sep 10; 2024 Aug 15. PMID: 39151428.", + "Spatial dynamics of mammalian brain development and neuroinflammation by multimodal tri-omics mapping. Fan R, Zhang D, Rodríguez-Kirby L, Lin Y, Song M, Wang L, Wang L, Kanatani S, Jimenez-Beristain T, Dang Y, Zhong M, Kukanja P, Wang S, Chen X, Gao F, Wang D, Xu H, Lou X, Liu Y, Chen J, Sestan N, Uhlen P, Kriegstein AR, Zhao H, Castelo-Branco G. Res Sq. 2024 Aug 12; 2024 Aug 12. PMID: 39184075.", + "A Curated Compendium of Transcriptomic Data for the Exploration of Neocortical Development. Sonthalia S, Adkins RS, Orvis J, Li G, Mato Blanco X, Casella A, Liu J, Stein-O'Brien G, Caffo B, Hertzano R, Mahurkar A, Gillis J, Werner J, Ma S, Micali N, Sestan N, Rakic P, Santpere G, Ament SA, Colantuoni C. bioRxiv. 2024 Aug 7; 2024 Aug 7. PMID: 38464021.", + "Spatial dynamics of mammalian brain development and neuroinflammation by multimodal tri-omics mapping. Zhang D, Rubio Rodríguez-Kirby LA, Lin Y, Song M, Wang L, Wang L, Kanatani S, Jimenez-Beristain T, Dang Y, Zhong M, Kukanja P, Wang S, Chen XL, Gao F, Wang D, Xu H, Lou X, Liu Y, Chen J, Sestan N, Uhlén P, Kriegstein A, Zhao H, Castelo-Branco G, Fan R. bioRxiv. 2024 Jul 28; 2024 Jul 28. PMID: 39091821.", + "Sex-Differential Gene Expression in Developing Human Cortex and Its Intersection With Autism Risk Pathways. Kissel LT, Pochareddy S, An JY, Sestan N, Sanders SJ, Wang X, Werling DM. Biol Psychiatry Glob Open Sci. 2024 Jul; 2024 Apr 26. PMID: 38957312.", + "Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells. Mato-Blanco X, Kim SK, Jourdon A, Ma S, Tebbenkamp ATN, Liu F, Duque A, Vaccarino FM, Sestan N, Colantuoni C, Rakic P, Santpere G, Micali N. bioRxiv. 2024 Jun 14; 2024 Jun 14. PMID: 38915580.", + "Single-cell genomics and regulatory networks for 388 human brains. Emani PS, Liu JJ, Clarke D, Jensen M, Warrell J, Gupta C, Meng R, Lee CY, Xu S, Dursun C, Lou S, Chen Y, Chu Z, Galeev T, Hwang A, Li Y, Ni P, Zhou X, Bakken TE, Bendl J, Bicks L, Chatterjee T, Cheng L, Cheng Y, Dai Y, Duan Z, Flaherty M, Fullard JF, Gancz M, Garrido-Martín D, Gaynor-Gillett S, Grundman J, Hawken N, Henry E, Hoffman GE, Huang A, Jiang Y, Jin T, Jorstad NL, Kawaguchi R, Khullar S, Liu J, Liu J, Liu S, Ma S, Margolis M, Mazariegos S, Moore J, Moran JR, Nguyen E, Phalke N, Pjanic M, Pratt H, Quintero D, Rajagopalan AS, Riesenmy TR, Shedd N, Shi M, Spector M, Terwilliger R, Travaglini KJ, Wamsley B, Wang G, Xia Y, Xiao S, Yang AC, Zheng S, Gandal MJ, Lee D, Lein ES, Roussos P, Sestan N, Weng Z, White KP, Won H, Girgenti MJ, Zhang J, Wang D, Geschwind D, Gerstein M. Science. 2024 May 24; 2024 May 24. PMID: 38781369.", + "Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain. Wen C, Margolis M, Dai R, Zhang P, Przytycki PF, Vo DD, Bhattacharya A, Matoba N, Tang M, Jiao C, Kim M, Tsai E, Hoh C, Aygün N, Walker RL, Chatzinakos C, Clarke D, Pratt H, Peters MA, Gerstein M, Daskalakis NP, Weng Z, Jaffe AE, Kleinman JE, Hyde TM, Weinberger DR, Bray NJ, Sestan N, Geschwind DH, Roeder K, Gusev A, Pasaniuc B, Stein JL, Love MI, Pollard KS, Liu C, Gandal MJ. Science. 2024 May 24; 2024 May 24. PMID: 38781368.", + "A novel SMARCC1 BAFopathy implicates neural progenitor epigenetic dysregulation in human hydrocephalus. Singh AK, Allington G, Viviano S, McGee S, Kiziltug E, Ma S, Zhao S, Mekbib KY, Shohfi JP, Duy PQ, DeSpenza T Jr, Furey CG, Reeves BC, Smith H, Sousa AMM, Cherskov A, Allocco A, Nelson-Williams C, Haider S, Rizvi SRA, Alper SL, Sestan N, Shimelis H, Walsh LK, Lifton RP, Moreno-De-Luca A, Jin SC, Kruszka P, Deniz E, Kahle KT. Brain. 2024 Apr 4. PMID: 38128548.", + "VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model. Boisserand LSB, Geraldo LH, Bouchart J, El Kamouh MR, Lee S, Sanganahalli BG, Spajer M, Zhang S, Lee S, Parent M, Xue Y, Skarica M, Yin X, Guegan J, Boyé K, Saceanu Leser F, Jacob L, Poulet M, Li M, Liu X, Velazquez SE, Singhabahu R, Robinson ME, Askenase MH, Osherov A, Sestan N, Zhou J, Alitalo K, Song E, Eichmann A, Sansing LH, Benveniste H, Hyder F, Thomas JL. J Exp Med. 2024 Apr 1; 2024 Mar 5. PMID: 38442272.", + "Single-cell genomics and regulatory networks for 388 human brains. Emani PS, Liu JJ, Clarke D, Jensen M, Warrell J, Gupta C, Meng R, Lee CY, Xu S, Dursun C, Lou S, Chen Y, Chu Z, Galeev T, Hwang A, Li Y, Ni P, Zhou X, Bakken TE, Bendl J, Bicks L, Chatterjee T, Cheng L, Cheng Y, Dai Y, Duan Z, Flaherty M, Fullard JF, Gancz M, Garrido-Martín D, Gaynor-Gillett S, Grundman J, Hawken N, Henry E, Hoffman GE, Huang A, Jiang Y, Jin T, Jorstad NL, Kawaguchi R, Khullar S, Liu J, Liu J, Liu S, Ma S, Margolis M, Mazariegos S, Moore J, Moran JR, Nguyen E, Phalke N, Pjanic M, Pratt H, Quintero D, Rajagopalan AS, Riesenmy TR, Shedd N, Shi M, Spector M, Terwilliger R, Travaglini KJ, Wamsley B, Wang G, Xia Y, Xiao S, Yang AC, Zheng S, Gandal MJ, Lee D, Lein ES, Roussos P, Sestan N, Weng Z, White KP, Won H, Girgenti MJ, Zhang J, Wang D, Geschwind D, Gerstein M. bioRxiv. 2024 Mar 30; 2024 Mar 30. PMID: 38562822.", + "Human-specific features and developmental dynamics of the brain N-glycome. Klarić TS, Gudelj I, Santpere G, Novokmet M, Vučković F, Ma S, Doll HM, Risgaard R, Bathla S, Karger A, Nairn AC, Luria V, Bečeheli I, Sherwood CC, Ely JJ, Hof PR, Sousa AMM, Josić D, Lauc G, Sestan N. Sci Adv. 2023 Dec 8; 2023 Dec 6. PMID: 38055821.", + "Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases. Garrison MA, Jang Y, Bae T, Cherskov A, Emery SB, Fasching L, Jones A, Moldovan JB, Molitor C, Pochareddy S, Peters MA, Shin JH, Wang Y, Yang X, Akbarian S, Chess A, Gage FH, Gleeson JG, Kidd JM, McConnell M, Mills RE, Moran JV, Park PJ, Sestan N, Urban AE, Vaccarino FM, Walsh CA, Weinberger DR, Wheelan SJ, Abyzov A. Sci Data. 2023 Nov 20; 2023 Nov 20. PMID: 37985666.", + "Abl2 repairs microtubules and phase separates with tubulin to promote microtubule nucleation. Duan D, Lyu W, Chai P, Ma S, Wu K, Wu C, Xiong Y, Sestan N, Zhang K, Koleske AJ. Curr Biol. 2023 Nov 6; 2023 Oct 18. PMID: 37858340.", + "Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon. Micali N, Ma S, Li M, Kim SK, Mato-Blanco X, Sindhu SK, Arellano JI, Gao T, Shibata M, Gobeske KT, Duque A, Santpere G, Sestan N, Rakic P. Science. 2023 Oct 13; 2023 Oct 13. PMID: 37824652.", + "A cross-species proteomic map reveals neoteny of human synapse development. Wang L, Pang K, Zhou L, Cebrián-Silla A, González-Granero S, Wang S, Bi Q, White ML, Ho B, Li J, Li T, Perez Y, Huang EJ, Winkler EA, Paredes MF, Kovner R, Sestan N, Pollen AA, Liu P, Li J, Piao X, García-Verdugo JM, Alvarez-Buylla A, Liu Z, Kriegstein AR. Nature. 2023 Oct; 2023 Sep 13. PMID: 37704727.", + "Molecular and cellular mechanisms of human cortical connectivity. Luria V, Ma S, Shibata M, Pattabiraman K, Sestan N. Curr Opin Neurobiol. 2023 Jun; 2023 Mar 13. PMID: 36921362.", + "VEGF-C promotes brain-derived fluid drainage, confers neuroprotection, and improves stroke outcomes. Simoes Braga Boisserand L, Bouchart J, Geraldo LH, Lee S, Sanganahalli BG, Parent M, Zhang S, Xue Y, Skarica M, Guegan J, Li M, Liu X, Poulet M, Askanase M, Osherov A, Spajer M, Kamouh ME, Eichmann A, Alitalo K, Zhou J, Sestan N, Sansing LH, Benveniste H, Hyder F, Thomas JL. bioRxiv. 2023 May 30; 2023 May 30. PMID: 37398128.", + "A neural stem cell paradigm of pediatric hydrocephalus. Duy PQ, Rakic P, Alper SL, Robert SM, Kundishora AJ, Butler WE, Walsh CA, Sestan N, Geschwind DH, Jin SC, Kahle KT. Cereb Cortex. 2023 Apr 4. PMID: 36097331.", + "A novel SMARCC1 -mutant BAFopathy implicates epigenetic dysregulation of neural progenitors in hydrocephalus. Singh AK, Viviano S, Allington G, McGee S, Kiziltug E, Mekbib KY, Shohfi JP, Duy PQ, DeSpenza T, Furey CG, Reeves BC, Smith H, Ma S, Sousa AMM, Cherskov A, Allocco A, Nelson-Williams C, Haider S, Rizvi SRA, Alper SL, Sestan N, Shimelis H, Walsh LK, Lifton RP, Moreno-De-Luca A, Jin SC, Kruszka P, Deniz E, Kahle KT. medRxiv. 2023 Mar 20; 2023 Mar 20. PMID: 36993720.", + "Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brain. Wen C, Margolis M, Dai R, Zhang P, Przytycki PF, Vo DD, Bhattacharya A, Matoba N, Jiao C, Kim M, Tsai E, Hoh C, Aygün N, Walker RL, Chatzinakos C, Clarke D, Pratt H, Consortium P, Peters MA, Gerstein M, Daskalakis NP, Weng Z, Jaffe AE, Kleinman JE, Hyde TM, Weinberger DR, Bray NJ, Sestan N, Geschwind DH, Roeder K, Gusev A, Pasaniuc B, Stein JL, Love MI, Pollard KS, Liu C, Gandal MJ. medRxiv. 2023 Mar 6; 2023 Mar 6. PMID: 36945630.", + "Human-specific features and developmental dynamics of the brain N-glycome. Klarić TS, Gudelj I, Santpere G, Sousa AMM, Novokmet M, Vučković F, Ma S, Bečeheli I, Sherwood CC, Ely JJ, Hof PR, Josić D, Lauc G, Sestan N. bioRxiv. 2023 Jan 11; 2023 Jan 11. PMID: 36711977.", + "Rare Variants: Shared Paths for Therapeutic Development and Neurobiological Investigation. Bearden CE, Chattarji S, Dolmetsch R, Iakoucheva LM, Kushner SA, Sahin M, Sestan N, Shimogori T, Sanders SJ. 2023. PMID: 39874409.", + "Spatiotemporal and genetic regulation of A-to-I editing throughout human brain development. Cuddleston WH, Fan X, Sloofman L, Liang L, Mossotto E, Moore K, Zipkowitz S, Wang M, Zhang B, Wang J, Sestan N, Devlin B, Roeder K, Sanders SJ, Buxbaum JD, Breen MS. Cell Rep. 2022 Nov 1. PMID: 36323256.", + "Developmental dynamics of RNA translation in the human brain. Duffy EE, Finander B, Choi G, Carter AC, Pritisanac I, Alam A, Luria V, Karger A, Phu W, Sherman MA, Assad EG, Pajarillo N, Khitun A, Crouch EE, Ganesh S, Chen J, Berger B, Sestan N, O'Donnell-Luria A, Huang EJ, Griffith EC, Forman-Kay JD, Moses AM, Kalish BT, Greenberg ME. Nat Neurosci. 2022 Oct; 2022 Sep 28. PMID: 36171426.", + "AgRP neurons control structure and function of the medial prefrontal cortex. Stutz B, Waterson MJ, Šestan-Peša M, Dietrich MO, Škarica M, Sestan N, Racz B, Magyar A, Sotonyi P, Liu ZW, Gao XB, Matyas F, Stoiljkovic M, Horvath TL. Mol Psychiatry. 2022 Oct; 2022 Jul 29. PMID: 35906488.", + "Molecular and cellular evolution of the primate dorsolateral prefrontal cortex. 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Copy Link Stanton Honig, MD -Azoospermia or “No Sperm in the Ejaculate” Stanton Honig, MD -Options for Increasing Testosterone If You Have Symptoms Stanton Honig, MD -Male Infertility Guideline Amendments Released Katherine Rotker, MD, and Stanton Honig, MD -Natural, Social, and Lifestyle Recommendations to Optimize Male Reproductive Health Stanton Honig, MD -Overturning Roe vs. Wade Causes Uptick in Vasectomy Consults Stanton Honig, MD -Treatment of Peyronie’s Disease Stanton Honig, MD -Personalizing Care for Patients with Low Testosterone Stanton Honig, MD -Newly-Released Guidelines for Male Infertility: Part 2 Stanton Honig, MD -Yale Urology Celebrates Men’s Health Month and Stresses the Importance of Health Screenings for African-American Men Stanton Honig, MD-Newly-Released Guidelines for Male Infertility: Part 1 Stanton Honig, MD-Can We Help Men Take Care of Themselves? Implications from The PRAMS Study Stanton Honig, MD-Yale Urology Pivots to Optimize Male Reproductive Evaluation and Treatment During COVID-19 Daniel Kellner, MD-Urinary Issues in Older Men Should Not Be Ignored Stanton Honig, MD-Azoospermia or \"No Sperm in the Ejaculate\" Stanton Honig, MD-Maximizing Success Rates and Minimizing Infection Rates for Penile Implants Stanton Honig, MD-At Home Sperm Testing: Should You Do it Early in the Course of Trying to Get Pregnant? Stanton Honig, MD-The Art of Titrating and Optimizing Penile Injection Therapy for Patients with Erectile Dysfunction Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Sight-Saving Engagement and Evaluation in New Haven (SEEN)", + "lab_url": "https://medicine.yale.edu/lab/seen/", + "research_bio": "INFORMATION FOR The Sight-Saving Engagement and Evaluation in New Haven seeks to decrease preventable blindness from diabetic retinopathy through research and community engagement. Our team employs quantitative and qualitative research methods to address health disparities in diabetic retinopathy. We not only identify and contextualize health disparities; we also design sustainable community engaged solutions along the path towards equity. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/seen/publications/", + "publications": [ + "Yale School of Medicine /", + "Ophthalmology /", + "Research/Projects", + "Publications", + "Eradicate TRD Webinar", + "In the News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research/Projects", + "Publications", + "Eradicate TRD Webinar", + "In the News", + "", + "", + "", + "", + "", + "", + "Digital Health Tool for Preventing Blindness From Diabetic Retinopathy: Protocol for a Qualitative Study. Frimpong A, Granados A, Chang T, Fu J, Applebaum SS, Moore SG, Kaur M, Adepoju B, Hari Krishnan V, Levi A, McCall T, Nwanyanwu KH. JMIR Res Protoc. 2025 Nov 12; 2025 Nov 12. PMID: 41223405.", + "Risk Factors and Consequences of Lapses in Proliferative Diabetic Retinopathy Care in a National Cohort. Applebaum SS, Deng Y, Fu JJ, Kane M, Nwanyanwu KH. Diabetes Care. 2025 Nov 1. PMID: 40956999.", + "Proliferative Diabetic Retinopathy Disproportionately Impacts Distressed Communities Near a Northeastern Academic Center. Frimpong AA, Chang TL, Weiss JM, Assanah-Lewis BG, Lu MC, Nwanyanwu KH. Ophthalmol Sci. 2025 Nov-Dec; 2025 Jun 30. PMID: 40893619.", + "Social Determinants Associated with Diabetic Retinopathy Awareness: National Health and Nutrition Examination Survey (2005-2008). Nwanyanwu K, Andoh J, Chen E, Xu Y, Granados A, Deng Y, Desai M, Nunez-Smith M. Am J Ophthalmol. 2025 Oct; 2025 Jun 21. PMID: 40550446.", + "Quality of Care in Patients With Newly Diagnosed Glaucoma. Ige MO, French DD, Chaudhury AS, Li Y, Andrews CA, Kanwar K, Zhou X, Marwah S, Evans CT, Kho AN, Bryar PJ, Stein JD. JAMA Ophthalmol. 2025 Sep 18; 2025 Sep 18. PMID: 40965904.", + "Recommendations for Designing a Digital Health Tool for Blindness Prevention Among High-Risk Diabetic Retinopathy Patients: Qualitative Focus Group Study of Adults With Diabetes. Frimpong A, Granados A, Chang T, Fu J, Moore SG, Applebaum S, Adepoju B, Kaur M, Hari Krishnan V, Levi A, McCall T, Nwanyanwu KH. JMIR Form Res. 2025 Jun 13; 2025 Jun 13. PMID: 40513002.", + "Association between Systemic Methotrexate Therapy and Proliferative Vitreoretinopathy. Chen X, Keenan JD, Stewart JM. Ophthalmol Retina. 2025 May; 2024 Nov 5. PMID: 39505109.", + "Nationwide Prevalence and Geographic Variation of Idiopathic Intracranial Hypertension among Women in the United States. Fraz MA, Kim BM, Chen JJ, Lum F, Chen J, Liu GT, Hamedani AG. Ophthalmology. 2025 Apr; 2024 Nov 6. PMID: 39510331.", + "Duration and Frequency of Lapses in Care Among Patients with Proliferative Diabetic Retinopathy. Applebaum S, Fu J, Nwanyanwu K. Ophthalmic Epidemiol. 2025 Mar 25; 2025 Mar 25. PMID: 40131442.", + "Incidence of Uveitis Following Initiation of Prostaglandin Analogs versus Other Glaucoma Medications: A Study from the Sight Outcomes Research Collaborative Repository. Chauhan MZ, Elhusseiny AM, Marwah S, Sallam AB, Stein JD, Kishor KS. Ophthalmol Glaucoma. 2025 Mar-Apr; 2024 Nov 13. PMID: 39542214.", + "The Impact of Race, Ethnicity, and Sex on Fairness in Artificial Intelligence for Glaucoma Prediction Models. Ravindranath R, Stein JD, Hernandez-Boussard T, Fisher AC, Wang SY. Ophthalmol Sci. 2025 Jan-Feb; 2024 Aug 14. PMID: 39386055.", + "Eye Care in Federally Qualified Health Centers. Woodward MA, Hicks PM, Harris-Nwanyanwu K, Modjtahedi B, Chan RVP, Vogt EL, Lu MC, Newman-Casey PA. Ophthalmology. 2024 Oct; 2024 Apr 30. PMID: 38697267.", + "Seeing in Color: Inclusion and Characterization of Hereditary Eye Disease in African Americans. Owete AC, Ionin R, Huryn LA, Cukras CA, Blain D, Agather AR, Hufnagel RB, Brooks BP, Nwanyanwu K, Zein WM. Transl Vis Sci Technol. 2024 Sep 3. PMID: 39226063.", + "Domestic Violence-Related Ocular Injuries Among Adult Patients: Data from the Nationwide Emergency Department Sample, 2008-2017. Andoh JE, Mehta SK, Chen EM, Mir TA, Nwanyanwu K, Teng CC. Ophthalmic Epidemiol. 2024 Apr; 2023 Jun 22. PMID: 37345877.", + "Epidemiologic trends of domestic violence-related ocular injuries among pediatric patients: data from the Nationwide Emergency Department Sample 2008-2017. Andoh JE, Miguez S, Andoh SE, Mehta S, Mir TA, Chen EM, Jain S, Teng CC, Nwanyanwu K. J AAPOS. 2023 Dec; 2023 Nov 4. PMID: 37931837.", + "Factors Associated With Visual Impairment Among Adults With a History of Criminal Justice Involvement. Andoh JE, Mir TA, Teng CC, Wang EA, Nwanyanwu K. J Correct Health Care. 2023 Oct; 2023 Oct 9. PMID: 37733299.", + "Disparities in Eye Care Access and Utilization: A Narrative Review. Andoh JE, Ezekwesili AC, Nwanyanwu K, Elam A. Annu Rev Vis Sci. 2023 Sep 15; 2023 May 30. PMID: 37254050.", + "Racial, Ethnic, and Socioeconomic Disparities Drive Appointment No-Show in Patients with Chronic Eye Disease. Greig EC, Gonzalez-Colaso R, Nwanyanwu K. J Racial Ethn Health Disparities. 2023 Aug; 2022 Jul 21. PMID: 35864353.", + "Data Sciences and Visual Health Disparities. Legault G, Nwanyanwu K, Baxter SL. Ophthalmology. 2022 Oct; 2022 Sep 1. PMID: 36058740.", + "Disparities in Vision Health and Eye Care. Elam AR, Tseng VL, Rodriguez TM, Mike EV, Warren AK, Coleman AL. Ophthalmology. 2022 Oct; 2022 Sep 1. PMID: 36058735.", + "Data Sources for Evaluating Health Disparities in Ophthalmology: Where We Are and Where We Need to Go. Baxter SL, Nwanyanwu K, Legault G, Lee AY. Ophthalmology. 2022 Oct; 2022 Sep 1. PMID: 36058733.", + "The Impact of Image Processing Algorithms on Optical Coherence Tomography Angiography Metrics and Study Conclusions in Diabetic Retinopathy. Freedman IG, Li E, Hui L, Adelman RA, Nwanyanwu K, Wang JC. Transl Vis Sci Technol. 2022 Sep 1. PMID: 36107113.", + "Deep learning for quality assessment of optical coherence tomography angiography images. Dhodapkar RM, Li E, Nwanyanwu K, Adelman R, Krishnaswamy S, Wang JC. Sci Rep. 2022 Aug 12; 2022 Aug 12. PMID: 35962007.", + "Elevating Social Determinants of Health and Community Engagement in Eye Care-The Time Is Now. Elam AR, Nwanyanwu KH, Scott AW. JAMA Ophthalmol. 2022 May 1. PMID: 35323858.", + "Participatory Science-The Path Toward Health Equity. Nwanyanwu K. JAMA Ophthalmol. 2022 Feb 1. PMID: 34913957.", + "Socioeconomic and Demographic Disparities in the Use of Telemedicine for Ophthalmic Care during the COVID-19 Pandemic. Chen EM, Andoh JE, Nwanyanwu K. Ophthalmology. 2022 Jan; 2021 Jul 8. PMID: 34245753.", + "Addressing Disparities in Ophthalmic Research: The Time Is Now. Nwanyanwu K, Scott AW, Elam AR. JAMA Ophthalmol. 2021 Dec 1. PMID: 34673894.", + "Awareness of Diabetic Retinopathy: Insight From the National Health and Nutrition Examination Survey. Nwanyanwu KMJH, Nunez-Smith M, Gardner TW, Desai MM. Am J Prev Med. 2021 Dec; 2021 Aug 21. PMID: 34426057.", + "Addressing Disparities in Eye Care-The Time Is Now. Scott AW, Elam AR, Nwanyanwu K. JAMA Ophthalmol. 2021 Sep 1. PMID: 34351375.", + "Ophthalmology Departments Remain Among the Least Diverse Clinical Departments at United States Medical Schools. Fairless EA, Nwanyanwu KH, Forster SH, Teng CC. Ophthalmology. 2021 Aug; 2021 Jan 10. PMID: 33440211.", + "Ophthalmic Emergency Department Visits: Factors Associated With Loss to Follow-up. Chen EM, Ahluwalia A, Parikh R, Nwanyanwu K. Am J Ophthalmol. 2021 Feb; 2020 Sep 1. PMID: 32882220.", + "Ophthalmic Medication Expenditures and Out-of-Pocket Spending: An Analysis of United States Prescriptions from 2007 through 2016. Chen EM, Kombo N, Teng CC, Mruthyunjaya P, Nwanyanwu K, Parikh R. Ophthalmology. 2020 Oct; 2020 Apr 28. PMID: 32359935.", + "Neighborhood Deprivation and Adherence to Initial Diabetic Retinopathy Screening. Yusuf R, Chen EM, Nwanyanwu K, Richards B. Ophthalmol Retina. 2020 May; 2020 Jan 28. PMID: 32139294.", + "Barriers to and Facilitators of Diabetic Retinopathy Screening Utilization in a High-Risk Population. Fairless E, Nwanyanwu K. J Racial Ethn Health Disparities. 2019 Dec; 2019 Aug 28. PMID: 31463812.", + "Hemorrhagic occlusive retinal vasculitis leading to the diagnosis of ciliary body melanoma. Williams BK Jr, Joel Welch R, Nwanyanwu KH, Shields CL. Saudi J Ophthalmol. 2019 Jan-Mar; 2018 Sep 24. PMID: 30930668.", + "Spontaneous Rupture of an Iris Stromal Cyst. Hall LB, Nwanyanwu K. Ophthalmology. 2018 Jan. PMID: 29268865.", + "Systematic Review of Community-Engaged Research in Ophthalmology. Nwanyanwu KH, Grossetta Nardini HK, Shaughness G, Nunez-Smith M, Newman-Casey PA. Expert Rev Ophthalmol. 2017; 2017 Apr 19. PMID: 29333193.", + "Ocular Syphilis Presenting as Bilateral Acute Retinal Necrosis in an Immunocompetent Host. Hussnain SA, Ketner S, Coady PA, Kombo N, Nwanyanwu K. Conn Med. 2016 Oct. PMID: 29772137.", + "Idiopathic retinal vasculitis, aneurysms and neuroretinitis case report. Alasil T, Ketner S, Coady PA, Adelman RA, Nwanyanwu KH. Am J Ophthalmol Case Rep. 2016 Jul; 2016 Apr 14. PMID: 29503895.", + "Beyond HbA(1c): Environmental Risk Factors for Diabetic Retinopathy. Nwanyanwu KH, Newman-Casey PA, Gardner TW, Lim JI. J Clin Exp Ophthalmol. 2015 Apr; 2015 Mar 13. PMID: 26973797.", + "Reduced fluorescein angiography and fundus photography use in the management of neovascular macular degeneration and macular edema during the past decade. Schneider EW, Mruthyunjaya P, Talwar N, Harris Nwanyanwu K, Nan B, Stein JD. Invest Ophthalmol Vis Sci. 2014 Jan 29; 2014 Jan 29. PMID: 24346174.", + "Smudge in my vision. Nwanyanwu KH, Lim JI. JAMA Ophthalmol. 2013 Dec. PMID: 24337560.", + "Cost-effectiveness of various interventions for newly diagnosed diabetic macular edema. Stein JD, Newman-Casey PA, Kim DD, Nwanyanwu KH, Johnson MW, Hutton DW. Ophthalmology. 2013 Sep; 2013 May 1. PMID: 23642372.", + "Predicting development of proliferative diabetic retinopathy. Harris Nwanyanwu K, Talwar N, Gardner TW, Wrobel JS, Herman WH, Stein JD. Diabetes Care. 2013 Jun; 2012 Dec 28. PMID: 23275374.", + "Presumed choroidal metastasis secondary to clear cell sarcoma of the right knee. Nwanyanwu KH, Comer G, Demirci H. Int Ophthalmol. 2013 Apr; 2012 Sep 28. PMID: 23053771.", + "Transient monocular vision loss due to churg-strauss syndrome vasculitis. Harris Nwanyanwu KM, De Lott LB, Cornblath WT, Elner VM. JAMA Ophthalmol. 2013 Jan. PMID: 23307226.", + "Maps & Directions", + "Calendar", + "Contact Us", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Simons Lab", + "lab_url": "https://medicine.yale.edu/lab/simons/", + "research_bio": "INFORMATION FOR The two principle research themes in the lab are the mechanisms of arterial and lymphatics formation and angiogenic growth factor signaling. These process are investigated at all levels, including in vitro signaling studies, in vivo mouse transgenic and knock-out models and translational studies in larger animal models and in early phase clinical trials. Arteriogenesis studies are currently concentrating on interactions of FGF, VEGF, Notch/Delta and WNT signaling pathways. Growth factor signaling studies are exploring cross-talks between different signaling pathways and the role of receptor trafficking in regulation of tyrosine kinase receptors signaling. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/simons/publications/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Cardiovascular Medicine /", + "Recent Publications Key Publications", + "Key Publications", + "Current Funding", + "People", + "Lab News Lab News", + "Lab News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Home", + "Recent Publications", + "Key Publications", + "", + "", + "", + "", + "", + "", + "Associations of daily step count with all-cause mortality and cardiovascular mortality in hypertensive US adults: a cohort study from NHANES 2005-2006. Guo T, Zhou Y, Yang G, Zhong A, Pan X, Pu Y, Simons M, Sheng L, Chai X. BMC Public Health. 2025 Jan 11; 2025 Jan 11. PMID: 39799282.", + "Anti-Syndecan 2 Antibody Treatment Reduces Edema Formation and Inflammation of Murine Laser-Induced CNV. Corti F, Locri F, Plastino F, Perrotta P, Zsebo K, Ristori E, Yin X, Song E, André H, Simons M. Transl Vis Sci Technol. 2025 Jan 2. PMID: 39792057.", + "Shear stress is uncoupled from atheroprotective KLK10 in atherosclerotic plaques. Zhou Z, Korteland SA, Tardajos-Ayllon B, Wu J, Chambers E, Weninck J, Simons M, Dunning M, Schenkel T, Diagbouga M, Wentzel J, Fragiadaki M, Evans PC. Atherosclerosis. 2024 Nov; 2024 Oct 4. PMID: 39413592.", + "Glycolysis in hepatic stellate cells coordinates fibrogenic extracellular vesicle release spatially to amplify liver fibrosis. Khanal S, Liu Y, Bamidele AO, Wixom AQ, Washington AM, Jalan-Sakrikar N, Cooper SA, Vuckovic I, Zhang S, Zhong J, Johnson KL, Charlesworth MC, Kim I, Yeon Y, Yoon S, Noh YK, Meroueh C, Timbilla AA, Yaqoob U, Gao J, Kim Y, Lucien F, Huebert RC, Hay N, Simons M, Shah VH, Kostallari E. Sci Adv. 2024 Jun 28; 2024 Jun 28. PMID: 38941469.", + "SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis. Ren R, Ding S, Ma K, Jiang Y, Wang Y, Chen J, Wang Y, Kou Y, Fan X, Zhu X, Qin L, Qiu C, Simons M, Wei X, Yu L. Circ Res. 2024 Jan 19; 2024 Jan 3. PMID: 38166414.", + "Report from the 2023 workshop on endothelial permeability, edema and inflammation. Vestweber D, Claesson-Welsh L, McDonald DM, Williams T, Schwartz MA, Scallan J, Gavins FNE, van Buul J, Gamble J, Vadas M, Annex BH, Messe SR, Perretti M, André H, Ferrara N, Hla T, Nourshargh S, Simons M. Nat Cardiovasc Res. 2023 Dec. PMID: 39196154.", + "Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/Src. Sjöberg E, Melssen M, Richards M, Ding Y, Chanoca C, Chen D, Nwadozi E, Pal S, Love DT, Ninchoji T, Shibuya M, Simons M, Dimberg A, Claesson-Welsh L. J Clin Invest. 2023 Oct 16; 2023 Oct 16. PMID: 37651195.", + "TNFα increases the degradation of pyruvate dehydrogenase kinase 4 by the Lon protease to support proinflammatory genes. Boutagy NE, Fowler JW, Grabinska KA, Cardone R, Sun Q, Vazquez KR, Whalen MB, Zhu X, Chakraborty R, Martin KA, Simons M, Romanoski CE, Kibbey RG, Sessa WC. Proc Natl Acad Sci U S A. 2023 Sep 19; 2023 Sep 11. PMID: 37695914.", + "Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary Hypertension. Zhou X, Jiang Y, Wang Y, Fan L, Zhu Y, Chen Y, Wang Y, Zhu Y, Wang H, Pan Z, Li Z, Zhu X, Ren R, Ge Z, Lai D, Lai EY, Chen T, Wang K, Liang P, Qin L, Liu C, Qiu C, Simons M, Yu L. Circ Res. 2023 Sep; 2023 Aug 17. PMID: 37589160.", + "Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption. Zarkada G, Chen X, Zhou X, Lange M, Zeng L, Lv W, Zhang X, Li Y, Zhou W, Liu K, Chen D, Ricard N, Liao J, Kim YB, Benedito R, Claesson-Welsh L, Alitalo K, Simons M, Ju R, Li X, Eichmann A, Zhang F. Circ Res. 2023 Aug 4; 2023 Jul 18. PMID: 37462027.", + "Endothelial-to-mesenchymal transition: advances and controversies. Simons M. Curr Opin Physiol. 2023 Aug; 2023 May 8. PMID: 37305156.", + "Acetate controls endothelial-to-mesenchymal transition. Zhu X, Wang Y, Soaita I, Lee HW, Bae H, Boutagy N, Bostwick A, Zhang RM, Bowman C, Xu Y, Trefely S, Chen Y, Qin L, Sessa W, Tellides G, Jang C, Snyder NW, Yu L, Arany Z, Simons M. Cell Metab. 2023 Jul 11; 2023 Jun 15. PMID: 37327791.", + "TGFβ signaling pathways in human health and disease. Chen PY, Qin L, Simons M. Front Mol Biosci. 2023; 2023 Jun 1. PMID: 37325472.", + "BMPR1A promotes ID2-ZEB1 interaction to suppress excessive endothelial to mesenchymal transition. Lee HW, Adachi T, Pak B, Park S, Hu X, Choi W, Kowalski PS, Chang CH, Clapham KR, Lee A, Papangeli I, Kim J, Han O, Park J, Anderson DG, Simons M, Jin SW, Chun HJ. Cardiovasc Res. 2023 May 2. PMID: 36166408.", + "High-resolution visualization of pial surface vessels by flattened whole mount staining. Xu Y, Zhang J, Lee HW, Zhang G, Bai Y, Simons M. iScience. 2023 Apr 21; 2023 Mar 22. PMID: 37020957.", + "Translational opportunities of single-cell biology in atherosclerosis. de Winther MPJ, Bäck M, Evans P, Gomez D, Goncalves I, Jørgensen HF, Koenen RR, Lutgens E, Norata GD, Osto E, Dib L, Simons M, Stellos K, Ylä-Herttuala S, Winkels H, Bochaton-Piallat ML, Monaco C. Eur Heart J. 2023 Apr 7. PMID: 36478058.", + "YES to Junctions, No to Src. Simons M, Toomre D. Nat Cardiovasc Res. 2022 Dec; 2022 Dec 7. PMID: 36938496.", + "Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model. Qin L, Jiang B, Zsebo K, Duckers HJ, Simons M, Chen PY. J Vis Exp. 2022 Nov 11; 2022 Nov 11. PMID: 36440832.", + "JAG1-NOTCH4 mechanosensing drives atherosclerosis. Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ, Ariaans M, Li J, Fang Y, Jørgensen HF, Simons M, Krams R, Waltenberger J, Fragiadaki M, Ridger V, De Val S, Francis SE, Chico TJ, Serbanovic-Canic J, Evans PC. Sci Adv. 2022 Sep 2; 2022 Aug 31. PMID: 36044575.", + "Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivo. Greuter T, Yaqoob U, Gan C, Jalan-Sakrikar N, Kostallari E, Lu J, Gao J, Sun L, Liu M, Sehrawat TS, Ibrahim SH, Furuta K, Nozickova K, Huang BQ, Gao B, Simons M, Cao S, Shah VH. J Hepatol. 2022 Sep; 2022 Apr 12. PMID: 35421427.", + "FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis. Zhu X, Qiu C, Wang Y, Jiang Y, Chen Y, Fan L, Ren R, Wang Y, Chen Y, Feng Y, Zhou X, Zhu Y, Ge Z, Lai D, Qin L, Simons M, Yu L. Proc Natl Acad Sci U S A. 2022 Jun 28; 2022 Jun 21. PMID: 35733256.", + "Flow goes forward and cells step backward: endothelial migration. Lee HW, Shin JH, Simons M. Exp Mol Med. 2022 Jun; 2022 Jun 14. PMID: 35701563.", + "Imaging and Analysis of Oil Red O-Stained Whole Aorta Lesions in an Aneurysm Hyperlipidemia Mouse Model. Chen PY, Qin L, Simons M. J Vis Exp. 2022 May 2; 2022 May 2. PMID: 35575528.", + "Endothelium-derived lactate is required for pericyte function and blood-brain barrier maintenance. Lee HW, Xu Y, Zhu X, Jang C, Choi W, Bae H, Wang W, He L, Jin SW, Arany Z, Simons M. EMBO J. 2022 May 2; 2022 Mar 3. PMID: 35243676.", + "Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort. Carapito R, Li R, Helms J, Carapito C, Gujja S, Rolli V, Guimaraes R, Malagon-Lopez J, Spinnhirny P, Lederle A, Mohseninia R, Hirschler A, Muller L, Bastard P, Gervais A, Zhang Q, Danion F, Ruch Y, Schenck M, Collange O, Chamaraux-Tran TN, Molitor A, Pichot A, Bernard A, Tahar O, Bibi-Triki S, Wu H, Paul N, Mayeur S, Larnicol A, Laumond G, Frappier J, Schmidt S, Hanauer A, Macquin C, Stemmelen T, Simons M, Mariette X, Hermine O, Fafi-Kremer S, Goichot B, Drenou B, Kuteifan K, Pottecher J, Mertes PM, Kailasan S, Aman MJ, Pin E, Nilsson P, Thomas A, Viari A, Sanlaville D, Schneider F, Sibilia J, Tharaux PL, Casanova JL, Hansmann Y, Lidar D, Radosavljevic M, Gulcher JR, Meziani F, Moog C, Chittenden TW, Bahram S. Sci Transl Med. 2022 Jan 19; 2022 Jan 19. PMID: 34698500.", + "MEKK3-TGFβ crosstalk regulates inward arterial remodeling. Deng H, Xu Y, Hu X, Zhuang ZW, Chang Y, Wang Y, Ntokou A, Schwartz MA, Su B, Simons M. Proc Natl Acad Sci U S A. 2021 Dec 21. PMID: 34911761.", + "Role of Venous Endothelial Cells in Developmental and Pathologic Angiogenesis. Lee HW, Xu Y, He L, Choi W, Gonzalez D, Jin SW, Simons M. Circulation. 2021 Oct 19; 2021 Sep 3. PMID: 34474596.", + "Activation of Smad2/3 signaling by low fluid shear stress mediates artery inward remodeling. Deng H, Min E, Baeyens N, Coon BG, Hu R, Zhuang ZW, Chen M, Huang B, Afolabi T, Zarkada G, Acheampong A, McEntee K, Eichmann A, Liu F, Su B, Simons M, Schwartz MA. Proc Natl Acad Sci U S A. 2021 Sep 14. PMID: 34504019.", + "Fibroblast growth factors: the keepers of endothelial normalcy. Simons M. J Clin Invest. 2021 Sep 1. PMID: 34623324.", + "Emerging roles of PLCγ1 in endothelial biology. Chen D, Simons M. Sci Signal. 2021 Aug 3; 2021 Aug 3. PMID: 34344833.", + "The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy. Ricard N, Bailly S, Guignabert C, Simons M. Nat Rev Cardiol. 2021 Aug; 2021 Feb 24. PMID: 33627876.", + "Developmental Perspectives on Arterial Fate Specification. Chen D, Schwartz MA, Simons M. Front Cell Dev Biol. 2021; 2021 Jun 25. PMID: 34249941.", + "Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells. Ristori E, Cicaloni V, Salvini L, Tinti L, Tinti C, Simons M, Corti F, Donnini S, Ziche M. Cells. 2020 Nov 19; 2020 Nov 19. PMID: 33228083.", + "In silico phenotype projection of endothelial ERK1/2 signaling. Simons M, Gulcher JR, Chittenden TW. Aging (Albany NY). 2020 Jun 12; 2020 Jun 12. PMID: 32530820.", + "Endothelial-to-Mesenchymal Transition, Vascular Inflammation, and Atherosclerosis. Chen PY, Schwartz MA, Simons M. Front Cardiovasc Med. 2020; 2020 May 5. PMID: 32478094.", + "Smooth Muscle Cell Reprogramming in Aortic Aneurysms. Chen PY, Qin L, Li G, Malagon-Lopez J, Wang Z, Bergaya S, Gujja S, Caulk AW, Murtada SI, Zhang X, Zhuang ZW, Rao DA, Wang G, Tobiasova Z, Jiang B, Montgomery RR, Sun L, Sun H, Fisher EA, Gulcher JR, Fernandez-Hernando C, Humphrey JD, Tellides G, Chittenden TW, Simons M. Cell Stem Cell. 2020 Apr 2. PMID: 32243809.", + "Chronic mTOR activation induces a degradative smooth muscle cell phenotype. Li G, Wang M, Caulk AW, Cilfone NA, Gujja S, Qin L, Chen PY, Chen Z, Yousef S, Jiao Y, He C, Jiang B, Korneva A, Bersi MR, Wang G, Liu X, Mehta S, Geirsson A, Gulcher JR, Chittenden TW, Simons M, Humphrey JD, Tellides G. J Clin Invest. 2020 Mar 2. PMID: 32039915.", + "Resilience, disease and the age of single cell science. Simons M, Chen PY, Chittenden TW. Aging (Albany NY). 2020 Feb 10; 2020 Feb 10. PMID: 32039835.", + "FRS2α-dependent cell fate transition during endocardial cushion morphogenesis. Chen D, Zhu X, Kofler N, Wang Y, Zhou B, Simons M. Dev Biol. 2020 Feb 1; 2019 Oct 25. PMID: 31669335.", + "Isoform-Specific Roles of ERK1 and ERK2 in Arteriogenesis. Ricard N, Zhang J, Zhuang ZW, Simons M. Cells. 2019 Dec 21; 2019 Dec 21. PMID: 31877781.", + "Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone NA, Kauffman KJ, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson DG, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz MA, Pober JS, Chittenden TW, Tellides G, Simons M. Nat Metab. 2019 Sep; 2019 Aug 26. PMID: 31572976.", + "Author Correction: SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis. Zhou HJ, Xu Z, Wang Z, Zhang H, Zhuang ZW, Simons M, Min W. Nat Commun. 2019 Aug 15; 2019 Aug 15. PMID: 31417083.", + "Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium. Ricard N, Scott RP, Booth CJ, Velazquez H, Cilfone NA, Baylon JL, Gulcher JR, Quaggin SE, Chittenden TW, Simons M. J Exp Med. 2019 Aug 5; 2019 Jun 13. PMID: 31196980.", + "Publisher Correction: N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA(165)-dependent neovascularization. Corti F, Wang Y, Rhodes JM, Atri D, Archer-Hartmann S, Zhang J, Zhuang ZW, Chen D, Wang T, Wang Z, Azadi P, Simons M. Nat Commun. 2019 May 7; 2019 May 7. PMID: 31064993.", + "N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA(165)-dependent neovascularization. Corti F, Wang Y, Rhodes JM, Atri D, Archer-Hartmann S, Zhang J, Zhuang ZW, Chen D, Wang T, Wang Z, Azadi P, Simons M. Nat Commun. 2019 Apr 5; 2019 Apr 5. PMID: 30952866.", + "Fibroblast growth factor-transforming growth factor beta dialogues, endothelial cell to mesenchymal transition, and atherosclerosis. Chen PY, Simons M. Curr Opin Lipidol. 2018 Oct. PMID: 30080704.", + "SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis. Zhou HJ, Xu Z, Wang Z, Zhang H, Zhuang ZW, Simons M, Min W. Nat Commun. 2018 Aug 17; 2018 Aug 17. PMID: 30120232.", + "Lacteal junction zippering protects against diet-induced obesity. Zhang F, Zarkada G, Han J, Li J, Dubrac A, Ola R, Genet G, Boyé K, Michon P, Künzel SE, Camporez JP, Singh AK, Fong GH, Simons M, Tso P, Fernández-Hernando C, Shulman GI, Sessa WC, Eichmann A. Science. 2018 Aug 10. PMID: 30093598.", + "Recent advances in understanding lymphangiogenesis and metabolism. Lee HW, Yu P, Simons M. F1000Res. 2018; 2018 Jul 20. PMID: 30079231.", + "Endothelial Metabolic Control of Lymphangiogenesis. Yu P, Wu G, Lee HW, Simons M. Bioessays. 2018 Jun; 2018 May 11. PMID: 29750374.", + "A unifying concept in vascular health and disease. Schwartz MA, Vestweber D, Simons M. Science. 2018 Apr 20. PMID: 29674582.", + "Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis. Lee MY, Gamez-Mendez A, Zhang J, Zhuang Z, Vinyard DJ, Kraehling J, Velazquez H, Brudvig GW, Kyriakides TR, Simons M, Sessa WC. Arterioscler Thromb Vasc Biol. 2018 Apr; 2018 Feb 15. PMID: 29449333.", + "Reprogramming the Endocardium: Trials and Tribulations. Chen D, Simons M. Circ Res. 2018 Mar 30. PMID: 29599272.", + "The Rab-effector protein RABEP2 regulates endosomal trafficking to mediate vascular endothelial growth factor receptor-2 (VEGFR2)-dependent signaling. Kofler N, Corti F, Rivera-Molina F, Deng Y, Toomre D, Simons M. J Biol Chem. 2018 Mar 30; 2018 Feb 7. PMID: 29425100.", + "Metabolic Analysis of Lymphatic Endothelial Cells. Yu P, Alves TC, Kibbey RG, Simons M. Methods Mol Biol. 2018. PMID: 30242770.", + "Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D, Kisseleva T, Brenner DA, Urrutia R, Lomberk G, Gao Y, Ligresti G, Tschumperlin DJ, Revzin A, Cao S, Shah VH. JCI Insight. 2017 Dec 21; 2017 Dec 21. PMID: 29263300.", + "SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling. Zhu X, Ding S, Qiu C, Shi Y, Song L, Wang Y, Wang Y, Li J, Wang Y, Sun Y, Qin L, Chen J, Simons M, Min W, Yu L. Circ Res. 2017 Sep 1; 2017 Jul 31. PMID: 28760777.", + "FGF-dependent metabolic control of vascular development. Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M. Nature. 2017 May 11; 2017 May 3. PMID: 28467822.", + "Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits. Burk K, Mire E, Bellon A, Hocine M, Guillot J, Moraes F, Yoshida Y, Simons M, Chauvet S, Mann F. Nat Commun. 2017 Feb 22; 2017 Feb 22. PMID: 28224988.", + "The molecular basis of endothelial cell plasticity. Dejana E, Hirschi KK, Simons M. Nat Commun. 2017 Feb 9; 2017 Feb 9. PMID: 28181491.", + "Modulation of VEGF receptor 2 signaling by protein phosphatases. Corti F, Simons M. Pharmacol Res. 2017 Jan; 2016 Nov 23. PMID: 27888154.", + "Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development. Wang Y, Baeyens N, Corti F, Tanaka K, Fang JS, Zhang J, Jin Y, Coon B, Hirschi KK, Schwartz MA, Simons M. Development. 2016 Dec 1; 2016 Oct 27. PMID: 27789626.", + "Mechanisms and regulation of endothelial VEGF receptor signalling. Simons M, Gordon E, Claesson-Welsh L. Nat Rev Mol Cell Biol. 2016 Oct; 2016 Jul 27. PMID: 27461391.", + "Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGFβ)-dependent smooth muscle cell phenotype modulation. Chen PY, Qin L, Li G, Tellides G, Simons M. Sci Rep. 2016 Sep 16; 2016 Sep 16. PMID: 27634335.", + "Sympathetic Innervation Promotes Arterial Fate by Enhancing Endothelial ERK Activity. Pardanaud L, Pibouin-Fragner L, Dubrac A, Mathivet T, English I, Brunet I, Simons M, Eichmann A. Circ Res. 2016 Aug 19; 2016 Jun 27. PMID: 27354211.", + "Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression. Chen PY, Qin L, Li G, Tellides G, Simons M. EMBO Mol Med. 2016 Jul; 2016 Jul 1. PMID: 27189169.", + "The expanding role of neuropilin: regulation of transforming growth factor-β and platelet-derived growth factor signaling in the vasculature. Kofler N, Simons M. Curr Opin Hematol. 2016 May. PMID: 26849476.", + "Future Targets in Endothelial Biology: Endothelial Cell to Mesenchymal Transition. Chen PY, Simons M. Curr Drug Targets. 2016. PMID: 27138761.", + "When endothelial cells go rogue. Chen PY, Simons M. EMBO Mol Med. 2016 Jan 1. PMID: 26613939.", + "Endothelial miR-17∼92 cluster negatively regulates arteriogenesis via miRNA-19 repression of WNT signaling. Landskroner-Eiger S, Qiu C, Perrotta P, Siragusa M, Lee MY, Ulrich V, Luciano AK, Zhuang ZW, Corti F, Simons M, Montgomery RL, Wu D, Yu J, Sessa WC. Proc Natl Acad Sci U S A. 2015 Oct 13; 2015 Sep 28. PMID: 26417068.", + "Myosin VI and cardiomyopathy: Left ventricular hypertrophy, fibrosis, and both cardiac and pulmonary vascular endothelial cell defects in the Snell's waltzer mouse. Hegan PS, Lanahan AA, Simons M, Mooseker MS. Cytoskeleton (Hoboken). 2015 Aug. PMID: 26265212.", + "Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis. Wang Y, Cao Y, Yamada S, Thirunavukkarasu M, Nin V, Joshi M, Rishi MT, Bhattacharya S, Camacho-Pereira J, Sharma AK, Shameer K, Kocher JP, Sanchez JA, Wang E, Hoeppner LH, Dutta SK, Leof EB, Shah V, Claffey KP, Chini EN, Simons M, Terzic A, Maulik N, Mukhopadhyay D. Arterioscler Thromb Vasc Biol. 2015 Jun; 2015 Apr 16. PMID: 25882068.", + "When it is better to regress: dynamics of vascular pruning. Ricard N, Simons M. PLoS Biol. 2015 May; 2015 May 15. PMID: 25978860.", + "Molecular controls of arterial morphogenesis. Simons M, Eichmann A. Circ Res. 2015 May 8. PMID: 25953926.", + "Endothelial cell metabolism in normal and diseased vasculature. Eelen G, de Zeeuw P, Simons M, Carmeliet P. Circ Res. 2015 Mar 27. PMID: 25814684.", + "Angiogenesis versus arteriogenesis: neuropilin 1 modulation of VEGF signaling. Kofler NM, Simons M. F1000Prime Rep. 2015; 2015 Mar 3. PMID: 25926977.", + "Molecular controls of lymphatic VEGFR3 signaling. Deng Y, Zhang X, Simons M. Arterioscler Thromb Vasc Biol. 2015 Feb; 2014 Dec 18. PMID: 25524775.", + "Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function. Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood DA, Schwartz M, Simons M, Sessa WC, Kyriakides TR. J Biol Chem. 2015 Jan 2; 2014 Nov 11. PMID: 25389299.", + "ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis. Chang SH, Elemento O, Zhang J, Zhuang ZW, Simons M, Hla T. Proc Natl Acad Sci U S A. 2014 Dec 23; 2014 Nov 24. PMID: 25422430.", + "Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling. Baeyens N, Mulligan-Kehoe MJ, Corti F, Simon DD, Ross TD, Rhodes JM, Wang TZ, Mejean CO, Simons M, Humphrey J, Schwartz MA. Proc Natl Acad Sci U S A. 2014 Dec 2; 2014 Nov 17. PMID: 25404299.", + "Lymphatic fate specification: an ERK-controlled transcriptional program. Yu P, Tung JK, Simons M. Microvasc Res. 2014 Nov; 2014 Aug 15. PMID: 25132472.", + "Fox(y) regulators of VEGF receptors. Ricard N, Simons M. Circ Res. 2014 Sep 26. PMID: 25258399.", + "Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium. Chen PY, Qin L, Tellides G, Simons M. Sci Signal. 2014 Sep 23; 2014 Sep 23. PMID: 25249657.", + "Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. Morrison AR, Yarovinsky TO, Young BD, Moraes F, Ross TD, Ceneri N, Zhang J, Zhuang ZW, Sinusas AJ, Pardi R, Schwartz MA, Simons M, Bender JR. J Exp Med. 2014 Sep 22; 2014 Sep 1. PMID: 25180062.", + "PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells. Lanahan AA, Lech D, Dubrac A, Zhang J, Zhuang ZW, Eichmann A, Simons M. Circulation. 2014 Sep 9; 2014 Jun 30. PMID: 24982127.", + "Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates. Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M, Sessa WC. Proc Natl Acad Sci U S A. 2014 Sep 2; 2014 Aug 18. PMID: 25136137.", + "A brief etymology of the collateral circulation. Faber JE, Chilian WM, Deindl E, van Royen N, Simons M. Arterioscler Thromb Vasc Biol. 2014 Sep; 2014 Jul 10. PMID: 25012127.", + "Receptor tyrosine kinases endocytosis in endothelium: biology and signaling. Zhang X, Simons M. Arterioscler Thromb Vasc Biol. 2014 Sep; 2014 Jun 12. PMID: 24925972.", + "Flow-regulated lymphatic vasculature development and signaling. Wang Y, Simons M. Vasc Cell. 2014; 2014 Jul 9. PMID: 25053993.", + "Vasa vasorum in normal and diseased arteries. Mulligan-Kehoe MJ, Simons M. Circulation. 2014 Jun 17. PMID: 24934463.", + "The docking protein FRS2α is a critical regulator of VEGF receptors signaling. Chen PY, Qin L, Zhuang ZW, Tellides G, Lax I, Schlessinger J, Simons M. Proc Natl Acad Sci U S A. 2014 Apr 15; 2014 Apr 2. PMID: 24706887.", + "Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance. Cao Z, Ding BS, Guo P, Lee SB, Butler JM, Casey SC, Simons M, Tam W, Felsher DW, Shido K, Rafii A, Scandura JM, Rafii S. Cancer Cell. 2014 Mar 17. PMID: 24651014.", + "Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis. Sakurai T, Woolls MJ, Jin SW, Murakami M, Simons M. PLoS One. 2014; 2014 Mar 6. PMID: 24603875.", + "Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways. Ju R, Zhuang ZW, Zhang J, Lanahan AA, Kyriakides T, Sessa WC, Simons M. J Biol Chem. 2014 Jan 3; 2013 Nov 14. PMID: 24235146.", + "Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Ding BS, Cao Z, Lis R, Nolan DJ, Guo P, Simons M, Penfold ME, Shido K, Rabbany SY, Rafii S. Nature. 2014 Jan 2; 2013 Nov 20. PMID: 24256728.", + "Endothelial cell-dependent regulation of arteriogenesis. Moraes F, Paye J, Mac Gabhann F, Zhuang ZW, Zhang J, Lanahan AA, Simons M. Circ Res. 2013 Oct 12; 2013 Jul 29. PMID: 23897694.", + "Need glucose to sprout: local metabolic control of angiogenesis. Eichmann A, Simons M. EMBO Mol Med. 2013 Oct; 2013 Aug 27. PMID: 23982994.", + "Endothelial signaling and the molecular basis of arteriovenous malformation. Atri D, Larrivée B, Eichmann A, Simons M. Cell Mol Life Sci. 2013 Sep 28; 2013 Sep 28. PMID: 24077895.", + "Syndecan-4 signaling at a glance. Elfenbein A, Simons M. J Cell Sci. 2013 Sep 1; 2013 Aug 22. PMID: 23970415.", + "Physiology. Lymphatics are in my veins. Simons M, Eichmann A. Science. 2013 Aug 9. PMID: 23929973.", + "300 George Street New Haven, CT 06510", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Sklar Lab", + "lab_url": "https://medicine.yale.edu/lab/sklar/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/sklar/publications/", + "publications": [ + "Yale School of Medicine /", + "Pathology /", + "Research", + "News", + "People", + "Publications", + "Contact", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "Contact", + "News", + "", + "", + "", + "", + "", + "", + "Concordance between Tumor Tissue and Plasma DNA Genotyping in the NCI-MATCH Trial (EAY131). Gouda MA, Janku F, Yuan Y, Drusbosky LM, Chen AP, Zheng X, Patel K, Hamilton SR, Routbort M, Tricoli JV, Williams PM, Iafrate AJ, Sklar J, Coffey B, Little RF, Arteaga CL, O'Dwyer PJ, Flaherty KT, Harris LN, Meric-Bernstam F. Clin Cancer Res. 2025 Oct 15. PMID: 40388547.", + "A Concordance Study among 26 NGS Laboratories Participating in the NCI Molecular Analysis for Therapy Choice Clinical Trial. Zane LK, Yee LM, Chang TC, Sklar J, Yang G, Wen JD, Li P, Harrington R, Sims DJ, Harper K, Trent JM, LoBello JR, Szelinger S, Benson K, Zeng J, Poorman K, Xu D, Frampton GM, Pavlick DC, Miller VA, Tandon B, Swat W, Weiss L, Funari VA, Conroy JM, Prescott JL, Chandra PK, Ma C, Champion KJ, Baschkopf GX, Fesko YA, Freitas TAK, Tomlins SA, Hovelson DH, White K, Sorrells S, Tell R, Beaubier N, King D, Li L, Kelly K, Uvalic J, Meyers B, Kolhe R, Lindeman NI, Baltay M, Sholl LM, Lopategui J, Vail E, Zhang W, Telatar M, Afkhami M, Hsiao SJ, Mansukhani MM, Adams E, Jiang L, Aldape KD, Raffeld M, Xi L, Stehr H, Segal JP, Aisner DL, Davies KD, Brown NA, Livingston RJ, Konnick EQ, Song W, Solomon JP, Walther Z, McShane LM, Harris LN, Chen AP, Tsongalis GJ, Hamilton SR, Flaherty KT, O'Dwyer PJ, Conley BA, Patton DR, Iafrate AJ, Williams PM, Tricoli JV, Karlovich C. Clin Cancer Res. 2025 Aug 14. PMID: 40465838.", + "Factors Associated With Withdrawal of Life-Sustaining Therapy After Out-of-Hospital Cardiac Arrest. Elfassy MD, Gewarges M, Fan S, McLean B, Tanaka D, Bagga A, Bennett SA, Janusonis I, Nadarajah S, Osei-Yeboah C, Rosh J, Teitelbaum D, Sklar JC, Basuita M, Scales DC, Luk AC, Dorian P. CJC Open. 2025 Apr; 2024 Nov 26. PMID: 40433137.", + "Discovery of Gene Fusions in Driver-Negative Cancer Samples From the National Cancer Institute-Molecular Analysis for Therapy Choice Screening Cohort. Kaluziak ST, Codd EM, Purohit R, Melli B, Kalyan P, Fordham JA, Kirkpatrick G, McShane LM, Chang TC, Yang G, Wang J, Williams PM, Karlovich C, Sklar J, Iafrate AJ. JCO Precis Oncol. 2024 Dec; 2024 Dec 5. PMID: 39637335.", + "NCI10066: a Phase 1/2 study of olaparib in combination with ramucirumab in previously treated metastatic gastric and gastroesophageal junction adenocarcinoma. Cecchini M, Cleary JM, Shyr Y, Chao J, Uboha N, Cho M, Shields A, Pant S, Goff L, Spencer K, Kim E, Stein S, Kortmansky JS, Canosa S, Sklar J, Swisher EM, Radke M, Ivy P, Boerner S, Durecki DE, Hsu CY, LoRusso P, Lacy J. Br J Cancer. 2024 Feb; 2023 Dec 22. PMID: 38135713.", + "Quantitative DNA Repair Biomarkers and Immune Profiling for Temozolomide and Olaparib in Metastatic Colorectal Cancer. Cecchini M, Zhang JY, Wei W, Sklar J, Lacy J, Zhong M, Kong Y, Zhao H, DiPalermo J, Devine L, Stein SM, Kortmansky J, Johung KL, Bindra RS, LoRusso P, Schalper KA. Cancer Res Commun. 2023 Jun; 2023 Jun 28. PMID: 37387791.", + "The NCI-MATCH trial: lessons for precision oncology. O'Dwyer PJ, Gray RJ, Flaherty KT, Chen AP, Li S, Wang V, McShane LM, Patton DR, Tricoli JV, Williams PM, Iafrate AJ, Sklar J, Mitchell EP, Takebe N, Sims DJ, Coffey B, Fu T, Routbort M, Rubinstein LV, Little RF, Arteaga CL, Marinucci D, Hamilton SR, Conley BA, Harris LN, Doroshow JH. Nat Med. 2023 Jun; 2023 Jun 15. PMID: 37322121.", + "Deletion of Jazf1 gene causes early growth retardation and insulin resistance in mice. Lee HY, Jang HR, Li H, Samuel VT, Dudek KD, Osipovich AB, Magnuson MA, Sklar J, Shulman GI. Proc Natl Acad Sci U S A. 2022 Dec 6; 2022 Nov 28. PMID: 36442127.", + "Glycemic variability and indices of glycemic control among pregnant women with type 1 diabetes (T1D) based on the use of continuous glucose monitoring share technology. Sklar J, Pyle L, Snell-Bergeon JK, Garcetti R, Joshee P, Demmitt JK, Polsky S. J Matern Fetal Neonatal Med. 2022 Dec; 2021 Dec 7. PMID: 34875947.", + "Somatic Genomic Testing in Patients With Metastatic or Advanced Cancer: ASCO Provisional Clinical Opinion. Chakravarty D, Johnson A, Sklar J, Lindeman NI, Moore K, Ganesan S, Lovly CM, Perlmutter J, Gray SW, Hwang J, Lieu C, André F, Azad N, Borad M, Tafe L, Messersmith H, Robson M, Meric-Bernstam F. J Clin Oncol. 2022 Apr 10; 2022 Feb 17. PMID: 35175857.", + "Clinical Efficacy of Olaparib in IDH1/IDH2-Mutant Mesenchymal Sarcomas. Eder JP, Doroshow DB, Do KT, Keedy VL, Sklar JS, Glazer P, Bindra R, Shapiro GI. JCO Precis Oncol. 2021 Nov. PMID: 34994649.", + "Ceralasertib-Mediated ATR Inhibition Combined With Olaparib in Advanced Cancers Harboring DNA Damage Response and Repair Alterations (Olaparib Combinations). Mahdi H, Hafez N, Doroshow D, Sohal D, Keedy V, Do KT, LoRusso P, Jürgensmeier J, Avedissian M, Sklar J, Glover C, Felicetti B, Dean E, Mortimer P, Shapiro GI, Eder JP. JCO Precis Oncol. 2021; 2021 Sep 7. PMID: 34527850.", + "Yale Cancer Center Precision Medicine Tumor Board: molecular findings alter a diagnosis and treatment plan. Gibson JA, Finberg KE, Nalbantoglu I, Cecchini M, Ganzak A, Walther Z, Sklar JL, Eder JP, Goldberg SB. Lancet Oncol. 2021 Mar. PMID: 33662283.", + "Molecular Landscape and Actionable Alterations in a Genomically Guided Cancer Clinical Trial: National Cancer Institute Molecular Analysis for Therapy Choice (NCI-MATCH). Flaherty KT, Gray RJ, Chen AP, Li S, McShane LM, Patton D, Hamilton SR, Williams PM, Iafrate AJ, Sklar J, Mitchell EP, Harris LN, Takebe N, Sims DJ, Coffey B, Fu T, Routbort M, Zwiebel JA, Rubinstein LV, Little RF, Arteaga CL, Comis R, Abrams JS, O'Dwyer PJ, Conley BA. J Clin Oncol. 2020 Nov 20; 2020 Oct 13. PMID: 33048619.", + "EBV-Positive Primary Large B-Cell Lymphoma: The Role of Immunohistochemistry and XPO1 in the Diagnosis of Mediastinal Lymphomas. Maracaja DLV, Puthenpura V, Pels SG, O'Malley DP, Sklar JL, Finberg KE, Xu ML. Appl Immunohistochem Mol Morphol. 2020 Nov/Dec. PMID: 31789821.", + "The Molecular Analysis for Therapy Choice (NCI-MATCH) Trial: Lessons for Genomic Trial Design. Flaherty KT, Gray R, Chen A, Li S, Patton D, Hamilton SR, Williams PM, Mitchell EP, Iafrate AJ, Sklar J, Harris LN, McShane LM, Rubinstein LV, Sims DJ, Routbort M, Coffey B, Fu T, Zwiebel JA, Little RF, Marinucci D, Catalano R, Magnan R, Kibbe W, Weil C, Tricoli JV, Alexander B, Kumar S, Schwartz GK, Meric-Bernstam F, Lih CJ, McCaskill-Stevens W, Caimi P, Takebe N, Datta V, Arteaga CL, Abrams JS, Comis R, O'Dwyer PJ, Conley BA. J Natl Cancer Inst. 2020 Oct 1. PMID: 31922567.", + "Yale Cancer Center Precision Medicine Tumor Board: new technology, new drugs, and the value of repeat testing. Hafez N, Walther Z, Eder JP, Sklar JL, Gettinger SN, Finberg KE, Goldberg SB. Lancet Oncol. 2020 Mar; 2020 Mar 2. PMID: 32950226.", + "Somatic PRKAR1A mutation in sporadic atrial myxoma with cerebral parenchymal metastases: a case report. Roque A, Kimbrough T, Traner C, Baehring JM, Huttner A, Adams J, Canosa S, Sklar J, Madri JA. J Med Case Rep. 2019 Dec 25; 2019 Dec 25. PMID: 31874650.", + "The Clinical Autopsy and Genomic Testing. Sklar J. Am J Pathol. 2019 Sep; 2019 Jun 11. PMID: 31199923.", + "Presentation of Liver Failure From a Pericardial Mass. Nguyen VQ, Workman V, Stendahl K, Young L, Sklar J, Baldassarre LA. Circ Cardiovasc Imaging. 2019 Jun; 2019 Jun 6. PMID: 31167559.", + "Yale Cancer Center Precision Medicine Tumor Board: one tumour, multiple targets. Stewart T, Finberg K, Walther Z, Sklar JL, Hafez N, Eder JP, Anderson K, Wilson F, Goldberg SB. Lancet Oncol. 2018 Dec; 2018 Nov 28. PMID: 32956641.", + "Yale Cancer Center Precision Medicine Tumor Board: two patients, one targeted therapy, different outcomes. Cecchini M, Walther Z, Sklar JL, Bindra RS, Petrylak DP, Eder JP, Goldberg SB. Lancet Oncol. 2018 Jan. PMID: 29304353.", + "Introduction to the Yale Precision Medicine Tumor Board. Cecchini M, Walther Z, Sklar JL, Bindra RS, Petrylak DP, Eder JP, Goldberg SB. Lancet Oncol. 2018 Jan. PMID: 29304351.", + "EGFR Exon 19 Deletion in Pancreatic Adenocarcinoma Responds to Erlotinib, Followed by T790M-Mediated Resistance. Cecchini M, Sklar J, Lacy J. J Natl Compr Canc Netw. 2017 Sep. PMID: 28874593.", + "Analytical Validation of the Next-Generation Sequencing Assay for a Nationwide Signal-Finding Clinical Trial: Molecular Analysis for Therapy Choice Clinical Trial. Lih CJ, Harrington RD, Sims DJ, Harper KN, Bouk CH, Datta V, Yau J, Singh RR, Routbort MJ, Luthra R, Patel KP, Mantha GS, Krishnamurthy S, Ronski K, Walther Z, Finberg KE, Canosa S, Robinson H, Raymond A, Le LP, McShane LM, Polley EC, Conley BA, Doroshow JH, Iafrate AJ, Sklar JL, Hamilton SR, Williams PM. J Mol Diagn. 2017 Mar; 2017 Feb 7. PMID: 28188106.", + "The JAZF1-SUZ12 fusion protein disrupts PRC2 complexes and impairs chromatin repression during human endometrial stromal tumorogenesis. Ma X, Wang J, Wang J, Ma CX, Gao X, Patriub V, Sklar JL. Oncotarget. 2017 Jan 17. PMID: 27845897.", + "Genome-wide detection of DNase I hypersensitive sites in single cells and FFPE tissue samples. Jin W, Tang Q, Wan M, Cui K, Zhang Y, Ren G, Ni B, Sklar J, Przytycka TM, Childs R, Levens D, Zhao K. Nature. 2015 Dec 3. PMID: 26605532.", + "A chimeric RNA characteristic of rhabdomyosarcoma in normal myogenesis process. Yuan H, Qin F, Movassagh M, Park H, Golden W, Xie Z, Zhang P, Sklar J, Li H. Cancer Discov. 2013 Dec; 2013 Oct 2. PMID: 24089019.", + "Molecular tumor profiling for prediction of response to anticancer therapies. Walther Z, Sklar J. Cancer J. 2011 Mar-Apr. PMID: 21427550.", + "Gene fusions and RNA trans-splicing in normal and neoplastic human cells. Li H, Wang J, Ma X, Sklar J. Cell Cycle. 2009 Jan 15; 2009 Jan 6. PMID: 19158498.", + "A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells. Li H, Wang J, Mor G, Sklar J. Science. 2008 Sep 5. PMID: 18772439.", + "Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. Li H, Ma X, Wang J, Koontz J, Nucci M, Sklar J. Proc Natl Acad Sci U S A. 2007 Dec 11; 2007 Dec 6. PMID: 18077430.", + "Absence of Y chromosome in human placental site trophoblastic tumor. Hui P, Wang HL, Chu P, Yang B, Huang J, Baergen RN, Sklar J, Yang XJ, Soslow RA. Mod Pathol. 2007 Oct; 2007 Jul 20. PMID: 17643092.", + "Immunoglobulin gene rearrangement analysis in cerebrospinal fluid of patients with lymphoproliferative processes. Baehring JM, Hochberg FH, Betensky RA, Longtine J, Sklar J. J Neurol Sci. 2006 Sep 25; 2006 Jun 9. PMID: 16764890.", + "Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Koontz JI, Soreng AL, Nucci M, Kuo FC, Pauwels P, van Den Berghe H, Dal Cin P, Fletcher JA, Sklar J. Proc Natl Acad Sci U S A. 2001 May 22. PMID: 11371647.", + "Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. Morgan JA, Yin Y, Borowsky AD, Kuo F, Nourmand N, Koontz JI, Reynolds C, Soreng L, Griffin CA, Graeme-Cook F, Harris NL, Weisenburger D, Pinkus GS, Fletcher JA, Sklar J. Cancer Res. 1999 Dec 15. PMID: 10626814.", + "Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers. Kuo FC, Sklar J. J Exp Med. 1997 Nov 3. PMID: 9348312.", + "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J. Mol Cell Biol. 1997 Oct. PMID: 9315665.", + "Detection of mutations by cleavage of DNA heteroduplexes with bacteriophage resolvases. Mashal RD, Koontz J, Sklar J. Nat Genet. 1995 Feb. PMID: 7719346.", + "TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, Sklar J. Cell. 1991 Aug 23. PMID: 1831692.", + "Rapid, nonradioactive detection of clonal T-cell receptor gene rearrangements in lymphoid neoplasms. Bourguin A, Tung R, Galili N, Sklar J. Proc Natl Acad Sci U S A. 1990 Nov. PMID: 2236063.", + "T cell receptor gene trans-rearrangements: chimeric gamma-delta genes in normal lymphoid tissues. Tycko B, Palmer JD, Sklar J. Science. 1989 Sep 15. PMID: 2551037.", + "Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin's disease. Weiss LM, Movahed LA, Warnke RA, Sklar J. N Engl J Med. 1989 Feb 23. PMID: 2536894.", + "Analysis of DNA surrounding the breakpoints of chromosomal translocations involving the beta T cell receptor gene in human lymphoblastic neoplasms. Reynolds TC, Smith SD, Sklar J. Cell. 1987 Jul 3. PMID: 3036364.", + "Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cleary ML, Smith SD, Sklar J. Cell. 1986 Oct 10. PMID: 2875799.", + "Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma. Cleary ML, Meeker TC, Levy S, Lee E, Trela M, Sklar J, Levy R. Cell. 1986 Jan 17. PMID: 3079673.", + "Individual tumors of multifocal EB virus-induced malignant lymphomas in tamarins arise from different B-cell clones. Cleary ML, Epstein MA, Finerty S, Dorfman RF, Bornkamm GW, Kirkwood JK, Morgan AJ, Sklar J. Science. 1985 May 10. PMID: 2986287.", + "Epstein-Barr virus-associated B-cell proliferations of diverse clonal origins after bone marrow transplantation in a 12-year-old patient with severe combined immunodeficiency. Shearer WT, Ritz J, Finegold MJ, Guerra IC, Rosenblatt HM, Lewis DE, Pollack MS, Taber LH, Sumaya CV, Grumet FC. N Engl J Med. 1985 May 2. PMID: 2984567.", + "Brady Memorial Laboratory 310 Cedar Street PO Box 208023 New Haven, CT 06520-8023 Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Library & Reference", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Small Lab", + "lab_url": "https://medicine.yale.edu/lab/small/", + "research_bio": "INFORMATION FOR Our lab has studied the mechanisms of taste, flavor and feeding in humans since the mid 90’s using lesion, neuroimaging, neuropsychology, metabolic, genetic and psychophysics methodologies. For more information about our current research please visit ourResearchandPublicationspages. Scripts and publicly shared data are available onResources. Copy Link Interested in participating in a study? Find more information on Participate (linked), by emailingMDPRC@yale.eduor calling 203-785-7646.", + "publications_page": "https://medicine.yale.edu/lab/small/publications/", + "publications": [ + "Yale School of Medicine /", + "Psychiatry /", + "People", + "Participate", + "Research", + "Resources", + "Publications", + "Positions", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "People", + "Research", + "Publications", + "Positions", + "Participate", + "Resources", + "", + "", + "", + "", + "", + "", + "MDPRC 1 Church St. New Haven, CT 06510 Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Social Gerontology and Health Lab", + "lab_url": "https://medicine.yale.edu/lab/monin/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Solomon Lab", + "lab_url": "https://medicine.yale.edu/lab/solomon/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/solomon/publications/", + "publications": null + }, + { + "lab_name": "Spudich Lab", + "lab_url": "https://medicine.yale.edu/lab/spudich/", + "research_bio": "INFORMATION FOR Copy Link Copy Link Copy Link Copy Link Serena Spudich, MD, MA 300 George St., Rm. 8300C New Haven, CT 06511 serena.spudich@yale.edu 203-737-5309 Copy Link", + "publications_page": "https://medicine.yale.edu/lab/spudich/publications/", + "publications": [ + "Yale School of Medicine /", + "Neurology /", + "Research HIV Associated Reservoirs and Comorbidities Study PET Brain Imaging Studies Primary Infection CNS Events Study Acute HIV and HIV Cure Studies YSCORCH", + "HIV Associated Reservoirs and Comorbidities Study", + "PET Brain Imaging Studies", + "Primary Infection CNS Events Study", + "Acute HIV and HIV Cure Studies", + "YSCORCH", + "News & Updates", + "People", + "Photos", + "Publications", + "Abstracts", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "People", + "Publications", + "Abstracts", + "News & Updates", + "Photos", + "", + "", + "", + "", + "", + "", + "Antiretroviral Therapy Intensification With Dolutegravir and/or Maraviroc Did Not Affect HIV-1 Cell-Associated DNA, RNA, and 2--LTR Circles Over 12 Weeks. Reed JC, Hall L, McKhann A, Kwak G, Goecker EA, Coombs RW, Chen H, Roa J, Vecchio A, Daar ES, Hunt PW, Marra CM, Campbell TB, Ma Q, Swaminathan S, Macatangay BJC, Morse GD, Miller T, Rusin D, Ha B, Alston-Smith B, Paul R, Letendre SL, Spudich SS, Greninger AL. Open Forum Infect Dis. 2025 Oct; 2025 Oct 1. PMID: 41141451.", + "Blood pressure and metabolic outcomes after efavirenz- or dolutegravir-based therapy started in acute HIV infection. Chan P, Moreland S, Sacdalan C, Colby DJ, Ocampo F, Promsena P, Sriplienchan S, Wattana J, Intasan J, Phanuphak N, Vasan S, Paul R, Trautmann L, Spudich S, Kroon E. HIV Med. 2025 Oct; 2025 Jul 30. PMID: 41047593.", + "Inside out: TNFa-RII and sexualized drug use in acute HIV predicts persistent depressive symptoms despite antiretroviral therapy. Chavez JV, Bolzenius J, Chan P, Cho K, Mannarino J, Sacdalan C, Farhadian S, Trautmann L, Ndhlovu LC, Tipsuk S, Crowell TA, Krebs SJ, Slike B, Suttichom D, Colby DJ, Phanuphak N, Kroon E, Vasan S, Sriplienchan S, Spudich S, Paul R, Carrico AW. Brain Behav Immun Health. 2025 Oct; 2025 Jul 28. PMID: 40808976.", + "CSF immune cell alterations in women with neuropsychiatric Long COVID. Orlinick B, Mehta S, McAlpine L, Khoshbakht S, Fertuzinhos S, Nelson A, Chiarella J, Das B, Patel V, Filippidis P, Corley MJ, Spudich SS, Farhadian SF. J Infect Dis. 2025 Sep 8; 2025 Sep 8. PMID: 40920586.", + "Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV. Holroyd KB, Chan P, Sacdalan C, Dumrongpisutikul N, Sriplienchan S, Promensa P, Sailasuta P, Pothisri M, Puttamaswin S, Vasan S, Valcour V, Trautmann L, Spudich S, Paul R, Bolenzius J. Neurology. 2025 May 27; 2025 May 6. PMID: 40327828.", + "Pharmacokinetic approaches to standardize antiviral exposure in cerebrospinal fluid. Avedissian SN, Mu Y, McCarthy C, Bosch RJ, Spudich S, Gandhi RT, McMahon DK, Eron JJ, Mellors JW, Liu J, Podany AT, Fletcher CV. Pharmacotherapy. 2025 May; 2025 Mar 28. PMID: 40152440.", + "Longitudinal CNS and systemic T-lymphocyte and monocyte activation before and after antiretroviral therapy beginning in primary HIV infection. Chan P, Li X, Li F, Emu B, Price RW, Spudich S. Front Immunol. 2025; 2025 Feb 25. PMID: 40070827.", + "Neuropsychiatric and laboratory outcomes of hepatitis C treatment in an early-treated HIV cohort in Thailand. Ocampo F, Sacdalan C, Pinyakorn S, Paudel M, Wansom T, Poltubtim N, Sriplienchan S, Phanuphak N, Paul R, Hsu D, Colby D, Trautmann L, Spudich S, Chan P. AIDS Res Ther. 2025 Feb 19; 2025 Feb 19. PMID: 39972347.", + "Multi-omic Characterization of HIV Effects at Single Cell Level across Human Brain Regions. Yang J, Agrawal K, Stanley J 3rd, Li R, Jacobs N, Wang H, Lu C, Qu R, Clarke D, Chen Y, Jiang Y, Bai D, Zheng S, Fox H, Ho YC, Huttner A, Gerstein M, Kluger Y, Zhang L, Spudich S. bioRxiv. 2025 Feb 8; 2025 Feb 8. PMID: 39975288.", + "The single-cell opioid responses in the context of HIV (SCORCH) consortium. Ament SA, Campbell RR, Lobo MK, Receveur JP, Agrawal K, Borjabad A, Byrareddy SN, Chang L, Clarke D, Emani P, Gabuzda D, Gaulton KJ, Giglio M, Giorgi FM, Gok B, Guda C, Hadas E, Herb BR, Hu W, Huttner A, Ishmam MR, Jacobs MM, Kelschenbach J, Kim DW, Lee C, Liu S, Liu X, Madras BK, Mahurkar AA, Mash DC, Mukamel EA, Niu M, O'Connor RM, Pagan CM, Pang APS, Pillai P, Repunte-Canonigo V, Ruzicka WB, Stanley J, Tickle T, Tsai SA, Wang A, Wills L, Wilson AM, Wright SN, Xu S, Yang J, Zand M, Zhang L, Zhang J, Akbarian S, Buch S, Cheng CS, Corley MJ, Fox HS, Gerstein M, Gummuluru S, Heiman M, Ho YC, Kellis M, Kenny PJ, Kluger Y, Milner TA, Moore DJ, Morgello S, Ndhlovu LC, Rana TM, Sanna PP, Satterlee JS, Sestan N, Spector SA, Spudich S, Tilgner HU, Volsky DJ, White OR, Williams DW, Zeng H. Mol Psychiatry. 2024 Dec; 2024 Jun 15. PMID: 38879719.", + "Medical comorbidities and lower myelin content are associated with poor cognition in young adults with perinatally acquired HIV. Patel PB, Prince DK, Bolenzius J, Ch'en P, Chiarella J, Kolind S, Vavasour I, Pedersen T, Levendovszky SR, Spudich S, Marra C, Paul R. AIDS. 2024 Nov 15; 2024 Aug 7. PMID: 39110577.", + "Neurosymptomatic HIV-1 CSF escape is associated with replication in CNS T cells and inflammation. Kincer LP, Dravid A, Trunfio M, Calcagno A, Zhou S, Vercesi R, Spudich S, Gisslen M, Price RW, Cinque P, Joseph SB. J Clin Invest. 2024 Oct 1; 2024 Oct 1. PMID: 39352388.", + "Changes in cerebrospinal fluid proteins across the spectrum of untreated and treated chronic HIV-1 infection. Hu Z, Cinque P, Dravid A, Hagberg L, Yilmaz A, Zetterberg H, Fuchs D, Gostner J, Blennow K, Spudich SS, Kincer L, Zhou S, Joseph SB, Swanstrom R, Price RW, Gisslén M. PLoS Pathog. 2024 Sep; 2024 Sep 24. PMID: 39316609.", + "Prevalence of detectable HIV-DNA and HIV-RNA in cerebrospinal fluid of youth with perinatal HIV and impaired cognition on antiretroviral therapy. Wagner TA, Tierney C, Huang S, Nichols S, Malee KM, Montañez NA, Coletti A, Spiegel HML, Krotje C, Bone F, Wilkins M, Abuogi L, Purswani M, Bearden A, Wiznia A, Agwu A, Chadwick EG, Richman D, Gandhi M, Mehta P, Macatangay B, Spector SA, Spudich S, Persaud D, Chahroudi A. AIDS. 2024 Aug 1; 2024 Jun 4. PMID: 38814693.", + "Central Nervous System Effects of Early HIV Infection and Consequences of Antiretroviral Therapy Initiation during Acute HIV. Chan P, Spudich S. Viruses. 2024 Jul 5; 2024 Jul 5. PMID: 39066244.", + "Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency. Pluvinage JV, Ngo T, Fouassier C, McDonagh M, Holmes BB, Bartley CM, Kondapavulur S, Hurabielle C, Bodansky A, Pai V, Hinman S, Aslanpour A, Alvarenga BD, Zorn KC, Zamecnik C, McCann A, Asencor AI, Huynh T, Browne W, Tubati A, Haney MS, Douglas VC, Louine M, Cree BAC, Hauser SL, Seeley W, Baranzini SE, Wells JA, Spudich S, Farhadian S, Ramachandran PS, Gillum L, Hales CM, Zikherman J, Anderson MS, Yazdany J, Smith B, Nath A, Suh G, Flanagan EP, Green AJ, Green R, Gelfand JM, DeRisi JL, Pleasure SJ, Wilson MR. Sci Transl Med. 2024 Jun 26; 2024 Jun 26. PMID: 38924428.", + "Framingham risk score based vascular outcomes in acute versus chronic HIV cohorts after 6 years of ART. Holroyd KB, Han WM, Apornpong T, Trautmann L, Gatechompol S, Hiransuthikul A, Ubolyam S, Sacdalan C, Sriplienchan S, Kanaprach R, Kerr S, Avihingsanon A, Spudich S, Chan P. HIV Med. 2024 Jun; 2024 Feb 21. PMID: 38383057.", + "Changes in Cerebrospinal Fluid Proteins across the Spectrum of Untreated and Treated Chronic HIV-1 Infection. Hu Z, Cinque P, Dravid A, Hagberg L, Yilmaz A, Zetterberg H, Fuchs D, Gostner J, Blennow K, Spudich SS, Kincer L, Zhou S, Joseph S, Swanstrom R, Price RW, Gisslén M. bioRxiv. 2024 May 5; 2024 May 5. PMID: 38746436.", + "Case-Control Study of Individuals With Small Fiber Neuropathy After COVID-19. McAlpine L, Zubair AS, Joseph P, Spudich S. Neurol Neuroimmunol Neuroinflamm. 2024 May; 2024 Apr 17. PMID: 38630952.", + "HIV-1-infected T cell clones are shared across cerebrospinal fluid and blood during ART. Wang M, Yoon J, Reisert H, Das B, Orlinick B, Chiarella J, Halvas EK, Mellors J, Pang AP, Barakat LA, Fikrig M, Cyktor J, Kluger Y, Spudich S, Corley MJ, Farhadian SF. JCI Insight. 2024 Apr 8; 2024 Apr 8. PMID: 38587074.", + "Neuropsychiatric and Laboratory Outcomes of Hepatitis C Treatment in an Early-Treated HIV Cohort in Thailand. Ocampo FF, Sacdalan C, Pinyakorn S, Paudel M, Wansom T, Poltubtim N, Sriplienchan S, Phanuphak N, Paul R, Hsu D, Colby D, Trautmann L, Spudich S, Chan P. Res Sq. 2024 Apr 3; 2024 Apr 3. PMID: 38645141.", + "New approaches for understanding the potential role of microbes in Alzheimer's disease. Whitson HE, Banks WA, Diaz MM, Frost B, Kellis M, Lathe R, Schmader KE, Spudich SS, Tanzi R, Garden G. Brain Behav Immun Health. 2024 Mar; 2024 Feb 21. PMID: 38435720.", + "Cerebrospinal fluid pleocytosis is associated with HIV-1 neuroinvasion during acute infection. Chan P, Moreland S, Sacdalan C, Kroon E, Colby D, Sriplienchan S, Pinyakorn S, Phanuphak N, Jagodzinski L, Valcour V, Vasan S, Paul R, Trautmann L, Spudich S. AIDS. 2024 Mar 1; 2023 Nov 22. PMID: 37916464.", + "CD4 dim CD8 bright T cells are inversely associated with neuro-inflammatory markers among people with HIV. Albalawi YA, Shull T, Virdi AK, Subra C, Mitchell J, Slike BM, Jian N, Krebs SJ, Sacdalan C, Ratnaratorn N, Hsu DC, Phanuphak N, Spudich S, Trautmann L, Al-Harthi L. AIDS. 2024 Jan 1; 2023 Oct 3. PMID: 37792358.", + "Self-Reported Neuropsychiatric Post-COVID-19 Condition and CSF Markers of Neuroinflammation. Farhadian SF, Reisert HD, McAlpine L, Chiarella J, Kosana P, Yoon J, Spudich S. JAMA Netw Open. 2023 Nov 1; 2023 Nov 1. PMID: 37948085.", + "Antiretroviral Therapy Intensification for Neurocognitive Impairment in Human Immunodeficiency Virus. Letendre SL, Chen H, McKhann A, Roa J, Vecchio A, Daar ES, Berzins B, Hunt PW, Marra CM, Campbell TB, Coombs RW, Ma Q, Swaminathan S, Macatangay BJC, Morse GD, Miller T, Rusin D, Greninger AL, Ha B, Alston-Smith B, Robertson K, Paul R, Spudich S. Clin Infect Dis. 2023 Sep 18. PMID: 37183889.", + "Consensus Competencies for Postgraduate Fellowship Training in Global Neurology. Schiess N, Kulo V, Anand P, Bearden DR, Berkowitz AL, Birbeck GL, Cervantes-Arslanian A, Chan P, Chishimba LC, Chow FC, Elicer I, Fleury A, Kinikar A, Kvalsund M, Mateen FJ, Mbonde AA, Meyer AL, O'Carroll CB, Ogunniyi A, Patel AA, Rubenstein M, Siddiqi OK, Spudich S, Tackett SA, Thakur KT, Vora N, Zunt J, Saylor DR. Neurology. 2023 Aug 22; 2023 Mar 30. PMID: 36997322.", + "Brain volumetrics differ by Fiebig stage in acute HIV infection. Bolzenius J, Sacdalan C, Ndhlovu LC, Sailasuta N, Trautmann L, Tipsuk S, Crowell TA, Suttichom D, Colby DJ, Phanuphak N, Chan P, Premeaux T, Kroon E, Vasan S, Hsu DC, Valcour V, Ananworanich J, Robb ML, Ake JA, Pohl KM, Sriplienchan S, Spudich S, Paul R. AIDS. 2023 May 1; 2023 Jan 27. PMID: 36723491.", + "Anti-SARS-CoV-2 and Autoantibody Profiling of a COVID-19 Patient With Subacute Psychosis Who Remitted After Treatment With Intravenous Immunoglobulin. McAlpine LS, Lifland B, Check JR, Angarita GA, Ngo TT, Chen P, Dandekar R, Alvarenga BD, Browne WD, Pleasure SJ, Wilson MR, Spudich SS, Farhadian SF, Bartley CM. Biol Psychiatry. 2023 May 1; 2022 Dec 5. PMID: 36481066.", + "Correlation between CD4/CD8 ratio and neurocognitive performance during early HIV infection. Le LT, Price RW, Gisslén M, Zetterberg H, Emu B, Fabre R, Christian P, Andersen S, Spudich S, Vassallo M. HIV Med. 2023 Apr; 2022 Sep 22. PMID: 36134890.", + "Biotypes of Central Nervous System Complications in People With Human Immunodeficiency Virus: Virology, Immunology, and Neuropathology. Joseph SB, Gianella S, Burdo TH, Cinque P, Gisslen M, Letendre S, Nath A, Morgello S, Ndhlovu LC, Spudich S. J Infect Dis. 2023 Mar 17. PMID: 36930640.", + "Immunological, Cognitive, and Psychiatric Outcomes After Initiating Efavirenz- and Dolutegravir-based Antiretroviral Therapy During Acute Human Immunodeficiency Virus Infection. Chan P, Yoon B, Colby D, Kroon E, Sacdalan C, Sriplienchan S, Pinyakorn S, Ananworanich J, Valcour V, Vasan S, Hsu D, Phanuphak N, Paul R, Spudich S. Clin Infect Dis. 2023 Feb 8. PMID: 35687498.", + "Rebound HIV-1 in cerebrospinal fluid after antiviral therapy interruption is mainly clonally amplified R5 T cell-tropic virus. Kincer LP, Joseph SB, Gilleece MM, Hauser BM, Sizemore S, Zhou S, Di Germanio C, Zetterberg H, Fuchs D, Deeks SG, Spudich S, Gisslen M, Price RW, Swanstrom R. Nat Microbiol. 2023 Feb; 2023 Jan 30. PMID: 36717718.", + "HIV-1 is Transported into the Central Nervous System by Trafficking Infected Cells. Kincer LP, Schnell G, Swanstrom R, Miller MB, Spudich S, Eron JJ, Price RW, Joseph SB. Pathog Immun. 2022; 2023 Jan 23. PMID: 36865569.", + "Individual Differences in CD4/CD8 T-Cell Ratio Trajectories and Associated Risk Profiles Modeled From Acute HIV Infection. Paul R, Cho K, Bolzenius J, Sacdalan C, Ndhlovu LC, Trautmann L, Krebs S, Tipsuk S, Crowell TA, Suttichom D, Colby DJ, Premeaux TA, Phanuphak N, Chan P, Kroon E, Vasan S, Hsu D, Carrico A, Valcour V, Ananworanich J, Robb ML, Ake JA, Sriplienchan S, Spudich S. Psychosom Med. 2022 Oct 1; 2022 Jul 6. PMID: 36162059.", + "Neuropathogenesis of HIV-1: insights from across the spectrum of acute through long-term treated infection. Killingsworth L, Spudich S. Semin Immunopathol. 2022 Sep; 2022 Jul 26. PMID: 35882661.", + "Cerebrospinal Fluid Viral Load Across the Spectrum of Untreated Human Immunodeficiency Virus Type 1 (HIV-1) Infection: A Cross-Sectional Multicenter Study. Ulfhammer G, Edén A, Antinori A, Brew BJ, Calcagno A, Cinque P, De Zan V, Hagberg L, Lin A, Nilsson S, Oprea C, Pinnetti C, Spudich S, Trunfio M, Winston A, Price RW, Gisslén M. Clin Infect Dis. 2022 Aug 31. PMID: 34747481.", + "Investigating vascular diseases in people living with HIV by nuclear imaging. Chan P, Spudich S. J Nucl Cardiol. 2022 Aug; 2021 Apr 21. PMID: 33884573.", + "HIV viral transcription and immune perturbations in the CNS of people with HIV despite ART. Farhadian SF, Lindenbaum O, Zhao J, Corley MJ, Im Y, Walsh H, Vecchio A, Garcia-Milian R, Chiarella J, Chintanaphol M, Calvi R, Wang G, Ndhlovu LC, Yoon J, Trotta D, Ma S, Kluger Y, Spudich S. JCI Insight. 2022 Jul 8; 2022 Jul 8. PMID: 35801589.", + "Infection and inflammation: New perspectives on Alzheimer's disease. Whitson HE, Colton C, El Khoury J, Gate D, Goate A, Heneka MT, Kaddurah-Daouk R, Klein RS, Shinohara ML, Sisodia S, Spudich SS, Stevens B, Tanzi R, Ting JP, Garden G. Brain Behav Immun Health. 2022 Jul; 2022 Apr 22. PMID: 36118272.", + "Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones. Collora JA, Liu R, Pinto-Santini D, Ravindra N, Ganoza C, Lama JR, Alfaro R, Chiarella J, Spudich S, Mounzer K, Tebas P, Montaner LJ, van Dijk D, Duerr A, Ho YC. Immunity. 2022 Jun 14; 2022 Mar 22. PMID: 35320704.", + "HIV Compartmentalization in the CNS and Its Impact in Treatment Outcomes and Cure Strategies. Chan P, Spudich S. Curr HIV/AIDS Rep. 2022 Jun; 2022 May 10. PMID: 35536438.", + "HIV Disease Dynamics and Markers of Inflammation and CNS Injury During Primary HIV Infection and Their Relationship to Cognitive Performance. Longino AA, Paul R, Wang Y, Lama JR, Brandes P, Ruiz E, Correa C, Keating S, Spudich SS, Pilcher C, Vecchio A, Pasalar S, Bender Ignacio RA, Valdez R, Dasgupta S, Robertson K, Duerr A. J Acquir Immune Defic Syndr. 2022 Feb 1. PMID: 34629415.", + "Nervous system consequences of COVID-19. Spudich S, Nath A. Science. 2022 Jan 21; 2022 Jan 20. PMID: 35050660.", + "Cerebrospinal fluid CD4+ T cell infection in humans and macaques during acute HIV-1 and SHIV infection. Sharma V, Creegan M, Tokarev A, Hsu D, Slike BM, Sacdalan C, Chan P, Spudich S, Ananworanich J, Eller MA, Krebs SJ, Vasan S, Bolton DL. PLoS Pathog. 2021 Dec; 2021 Dec 7. PMID: 34874976.", + "Preliminary In Vivo Evidence of Reduced Synaptic Density in Human Immunodeficiency Virus (HIV) Despite Antiretroviral Therapy. Weiss JJ, Calvi R, Naganawa M, Toyonaga T, Farhadian SF, Chintanaphol M, Chiarella J, Zheng MQ, Ropchan J, Huang Y, Pietrzak RH, Carson RE, Spudich S. Clin Infect Dis. 2021 Oct 20. PMID: 34050746.", + "Central Nervous System Safety During Brief Analytic Treatment Interruption of Antiretroviral Therapy Within 4 Human Immunodeficiency Virus Remission Trials: An Observational Study in Acutely Treated People Living With Human Immunodeficiency Virus. Hellmuth J, Muccini C, Colby DJ, Kroon E, de Souza M, Crowell TA, Chan P, Sacdalan C, Intasan J, Benjapornpong K, Tipsuk S, Puttamaswin S, Chomchey N, Valcour V, Sarnecki M, Tomaka F, Krebs SJ, Slike BM, Jagodzinski LL, Dumrongpisutikul N, Sailasuta N, Samboju V, Michael NL, Robb ML, Vasan S, Ananworanich J, Phanuphak P, Phanuphak N, Paul R, Spudich S. Clin Infect Dis. 2021 Oct 5. PMID: 32916708.", + "Prior Stroke and Age Predict Acute Ischemic Stroke Among Hospitalized COVID-19 Patients: A Derivation and Validation Study. Peng TJ, Jasne AS, Simonov M, Abdelhakim S, Kone G, Cheng YK, Rethana M, Tarasaria K, Herman AL, Baker AD, Yaghi S, Frontera JA, Sansing LH, Falcone GJ, Spudich S, Schindler J, Sheth KN, Sharma R. Front Neurol. 2021; 2021 Oct 4. PMID: 34675873.", + "RETRACTED: Remission of Subacute Psychosis in a COVID-19 Patient With an Antineuronal Autoantibody After Treatment With Intravenous Immunoglobulin. McAlpine LS, Lifland B, Check JR, Angarita GA, Ngo TT, Pleasure SJ, Wilson MR, Spudich SS, Farhadian SF, Bartley CM. Biol Psychiatry. 2021 Aug 15; 2021 Apr 12. PMID: 34001372.", + "Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART. Corley MJ, Sacdalan C, Pang APS, Chomchey N, Ratnaratorn N, Valcour V, Kroon E, Cho KS, Belden AC, Colby D, Robb M, Hsu D, Spudich S, Paul R, Vasan S, Ndhlovu LC. PLoS Pathog. 2021 Aug; 2021 Aug 13. PMID: 34388205.", + "VZV myelitis with secondary HIV CSF escape. Weiss JJ, Spudich S, Barakat L. BMJ Case Rep. 2021 Jun 29; 2021 Jun 29. PMID: 34187795.", + "Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients. McAlpine LS, Zubair AS, Maran I, Chojecka P, Lleva P, Jasne AS, Navaratnam D, Matouk C, Schindler J, Sheth KN, Chun H, Lee AI, Spudich S, Sharma R, Sansing LH. Stroke. 2021 Jun; 2021 May 10. PMID: 33966492.", + "Neuropathogenesis of acute coronavirus disease 2019. Farhadian SF, Seilhean D, Spudich S. Curr Opin Neurol. 2021 Jun 1. PMID: 33852526.", + "Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms. Song E, Bartley CM, Chow RD, Ngo TT, Jiang R, Zamecnik CR, Dandekar R, Loudermilk RP, Dai Y, Liu F, Sunshine S, Liu J, Wu W, Hawes IA, Alvarenga BD, Huynh T, McAlpine L, Rahman NT, Geng B, Chiarella J, Goldman-Israelow B, Vogels CBF, Grubaugh ND, Casanovas-Massana A, Phinney BS, Salemi M, Alexander JR, Gallego JA, Lencz T, Walsh H, Wapniarski AE, Mohanty S, Lucas C, Klein J, Mao T, Oh J, Ring A, Spudich S, Ko AI, Kleinstein SH, Pak J, DeRisi JL, Iwasaki A, Pleasure SJ, Wilson MR, Farhadian SF. Cell Rep Med. 2021 May 18; 2021 May 3. PMID: 33969321.", + "Compartmentalization of cerebrospinal fluid inflammation across the spectrum of untreated HIV-1 infection, central nervous system injury and viral suppression. Gisslen M, Keating SM, Spudich S, Arechiga V, Stephenson S, Zetterberg H, Di Germanio C, Blennow K, Fuchs D, Hagberg L, Norris PJ, Peterson J, Shacklett BL, Yiannoutsos CT, Price RW. PLoS One. 2021; 2021 May 13. PMID: 33983973.", + "Cognitive trajectories after treatment in acute HIV infection. Chan P, Kerr SJ, Kroon E, Colby D, Sacdalan C, Hellmuth J, Reiss P, Vasan S, Ananworanich J, Valcour V, Spudich S, Paul R. AIDS. 2021 May 1. PMID: 33534200.", + "Minimal detection of cerebrospinal fluid escape after initiation of antiretroviral therapy in acute HIV-1 infection. Handoko R, Chan P, Jagodzinski L, Pinyakorn S, Ubolyam S, Phanuphak N, Sacdalan C, Kroon E, Dumrongpisutikul N, Paul R, Valcour V, Ananworanich J, Vasan S, Spudich S. AIDS. 2021 Apr 1. PMID: 33306551.", + "Coronavirus disease 2019 and neurodegenerative disease: what will the future bring? McAlpine LS, Fesharaki-Zadeh A, Spudich S. Curr Opin Psychiatry. 2021 Mar 1. PMID: 33395100.", + "Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement. Song E, Bartley CM, Chow RD, Ngo TT, Jiang R, Zamecnik CR, Dandekar R, Loudermilk RP, Dai Y, Liu F, Hawes IA, Alvarenga BD, Huynh T, McAlpine L, Rahman NT, Geng B, Chiarella J, Goldman-Israelow B, Vogels CBF, Grubaugh ND, Casanovas-Massana A, Phinney BS, Salemi M, Alexander J, Gallego JA, Lencz T, Walsh H, Lucas C, Klein J, Mao T, Oh J, Ring A, Spudich S, Ko AI, Kleinstein SH, DeRisi JL, Iwasaki A, Pleasure SJ, Wilson MR, Farhadian SF. bioRxiv. 2020 Dec 9; 2020 Dec 9. PMID: 32935102.", + "Lessons from a neurology consult service for patients with COVID-19. McAlpine LS, Zubair AS, Moeller J, Baehring J, Spudich S. Lancet Neurol. 2020 Oct; 2020 Sep 16. PMID: 32949536.", + "Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients. Sheth KN, Mazurek MH, Yuen MM, Cahn BA, Shah JT, Ward A, Kim JA, Gilmore EJ, Falcone GJ, Petersen N, Gobeske KT, Kaddouh F, Hwang DY, Schindler J, Sansing L, Matouk C, Rothberg J, Sze G, Siner J, Rosen MS, Spudich S, Kimberly WT. JAMA Neurol. 2020 Sep 8; 2020 Sep 8. PMID: 32897296.", + "A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection. Kroon EDMB, Ananworanich J, Pagliuzza A, Rhodes A, Phanuphak N, Trautmann L, Mitchell JL, Chintanaphol M, Intasan J, Pinyakorn S, Benjapornpong K, Chang JJ, Colby DJ, Chomchey N, Fletcher JLK, Eubanks K, Yang H, Kapson J, Dantanarayana A, Tennakoon S, Gorelick RJ, Maldarelli F, Robb ML, Kim JH, Spudich S, Chomont N, Phanuphak P, Lewin SR, de Souza MS. J Virus Erad. 2020 Sep; 2020 Jul 18. PMID: 33251022.", + "Determinants of suboptimal CD4(+) T cell recovery after antiretroviral therapy initiation in a prospective cohort of acute HIV-1 infection. Handoko R, Colby DJ, Kroon E, Sacdalan C, de Souza M, Pinyakorn S, Prueksakaew P, Munkong C, Ubolyam S, Akapirat S, Chiarella J, Krebs S, Sereti I, Valcour V, Paul R, Michael NL, Phanuphak N, Ananworanich J, Spudich S. J Int AIDS Soc. 2020 Sep. PMID: 32949118.", + "Stroke Code Presentations, Interventions, and Outcomes Before and During the COVID-19 Pandemic. Jasne AS, Chojecka P, Maran I, Mageid R, Eldokmak M, Zhang Q, Nystrom K, Vlieks K, Askenase M, Petersen N, Falcone GJ, Wira CR 3rd, Lleva P, Zeevi N, Narula R, Amin H, Navaratnam D, Loomis C, Hwang DY, Schindler J, Hebert R, Matouk C, Krumholz HM, Spudich S, Sheth KN, Sansing LH, Sharma R. Stroke. 2020 Sep; 2020 Jul 31. PMID: 32755347.", + "Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019: A Review. Zubair AS, McAlpine LS, Gardin T, Farhadian S, Kuruvilla DE, Spudich S. JAMA Neurol. 2020 Aug 1. PMID: 32469387.", + "Cognitive disorders in people living with HIV. Winston A, Spudich S. Lancet HIV. 2020 Jul. PMID: 32621876.", + "Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19. Farhadian S, Glick LR, Vogels CBF, Thomas J, Chiarella J, Casanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, Fournier J, Bermejo S, Fauver JR, Alpert T, Wyllie AL, Turcotte C, Steinle M, Paczkowski P, Dela Cruz C, Wilen C, Ko AI, MacKay S, Grubaugh ND, Spudich S, Barakat LA. BMC Neurol. 2020 Jun 18; 2020 Jun 18. PMID: 32552792.", + "Single-cell transcriptional landscapes reveal HIV-1-driven aberrant host gene transcription as a potential therapeutic target. Liu R, Yeh YJ, Varabyou A, Collora JA, Sherrill-Mix S, Talbot CC Jr, Mehta S, Albrecht K, Hao H, Zhang H, Pollack RA, Beg SA, Calvi RM, Hu J, Durand CM, Ambinder RF, Hoh R, Deeks SG, Chiarella J, Spudich S, Douek DC, Bushman FD, Pertea M, Ho YC. Sci Transl Med. 2020 May 13. PMID: 32404504.", + "Resting-state neural signatures of depressive symptoms in acute HIV. Philippi CL, Reyna L, Nedderman L, Chan P, Samboju V, Chang K, Phanuphak N, Ratnaratorn N, Hellmuth J, Benjapornpong K, Dumrongpisutikul N, Pothisri M, Robb ML, Ananworanich J, Spudich S, Valcour V, Paul R. J Neurovirol. 2020 Apr; 2020 Jan 27. PMID: 31989446.", + "Regional brain volumetric changes despite 2 years of treatment initiated during acute HIV infection. Kallianpur KJ, Jahanshad N, Sailasuta N, Benjapornpong K, Chan P, Pothisri M, Dumrongpisutikul N, Laws E, Ndhlovu LC, Clifford KM, Paul R, Jagodzinski L, Krebs S, Ananworanich J, Spudich S, Valcour V. AIDS. 2020 Mar 1. PMID: 31725432.", + "Feasibility and safety of research sigmoid colon biopsy in a cohort of Thai men who have sex with men with acute HIV-1. Chintanaphol M, Sacdalan C, Pinyakorn S, Rerknimitr R, Ridtitid W, Prueksapanich P, Sereti I, Schuetz A, Crowell TA, Colby DJ, Robb ML, Phanuphak N, Ananworanich J, Spudich SS, Kroon E. J Virus Erad. 2020 Feb 20; 2020 Feb 20. PMID: 32175085.", + "Neuropsychiatric outcomes before and after switching to dolutegravir-based therapy in an acute HIV cohort. Chan P, Goh O, Kroon E, Colby D, Sacdalan C, Pinyakorn S, Prueksakaew P, Reiss P, Ananworanich J, Valcour V, Spudich S, Paul R. AIDS Res Ther. 2020 Jan 7; 2020 Jan 7. PMID: 31907064.", + "Liver function test abnormalities in a longitudinal cohort of Thai individuals treated since acute HIV infection. Peluso MJ, Colby DJ, Pinyakorn S, Ubolyam S, Intasan J, Trichavaroj R, Chomchey N, Prueksakaew P, Slike BM, Krebs SJ, Jian N, Robb ML, Phanuphak P, Phanuphak N, Spudich S, Ananworanich J, Kroon E. J Int AIDS Soc. 2020 Jan. PMID: 31953919.", + "Exosomal MicroRNAs Associate With Neuropsychological Performance in Individuals With HIV Infection on Antiretroviral Therapy. OʼMeara T, Kong Y, Chiarella J, Price RW, Chaudhury R, Liu X, Spudich S, Robertson K, Emu B, Lu L. J Acquir Immune Defic Syndr. 2019 Dec 15. PMID: 31714431.", + "Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL. Farhadian SF, Mistry H, Kirchwey T, Chiarella J, Calvi R, Chintanaphol M, Patel P, Landry ML, Robertson K, Spudich SS. Open Forum Infect Dis. 2019 Dec; 2019 Dec 14. PMID: 31893212.", + "Defining cerebrospinal fluid HIV RNA escape: editorial review AIDS. Winston A, Antinori A, Cinque P, Fox HS, Gisslen M, Henrich TJ, Letendre S, Persaud D, Price RW, Spudich S. AIDS. 2019 Dec 1. PMID: 31790376.", + "Potential for early antiretroviral therapy to reduce central nervous system HIV-1 persistence. Spudich S, Peterson J, Fuchs D, Price RW, Gisslen M. AIDS. 2019 Dec 1. PMID: 31789814.", + "HIV persistence in the central nervous system during antiretroviral therapy: evidence and implications. Spudich S, Clements JE. AIDS. 2019 Dec 1. PMID: 31789813.", + "Very Early Initiation of Antiretroviral Therapy During Acute HIV Infection Is Associated With Normalized Levels of Immune Activation Markers in Cerebrospinal Fluid but Not in Plasma. Hellmuth J, Slike BM, Sacdalan C, Best J, Kroon E, Phanuphak N, Fletcher JLK, Prueksakaew P, Jagodzinski LL, Valcour V, Robb M, Ananworanich J, Allen IE, Krebs SJ, Spudich S. J Infect Dis. 2019 Nov 6. PMID: 30668739.", + "Trajectory Analysis of Cognitive Outcomes in Children With Perinatal HIV. Patel PB, Apornpong T, Puthanakit T, Thongpibul K, Kosalaraksa P, Hansudewechakul R, Kanjanavanit S, Ngampiyaskul C, Luesomboon W, Wongsawat J, Sun LP, Chettra K, Saphonn V, Mellins CA, Malee K, Spudich S, Ananworanich J, Kerr SJ, Paul R. Pediatr Infect Dis J. 2019 Oct. PMID: 31568142.", + "Neurosyphilis During Acute HIV Infection: A CNS Immunologic and Virologic Characterization. Chan P, Dumrongpisutikul N, Subra C, Colby DJ, Kroon E, Fletcher J, Sacdalan C, Phanuphak N, Valcour V, Ananworanich J, Trautmann L, Spudich S. J Acquir Immune Defic Syndr. 2019 Oct 1. PMID: 31180994.", + "Human Immunodeficiency Virus Type 1 RNA Detected in the Central Nervous System (CNS) After Years of Suppressive Antiretroviral Therapy Can Originate from a Replicating CNS Reservoir or Clonally Expanded Cells. Joseph SB, Kincer LP, Bowman NM, Evans C, Vinikoor MJ, Lippincott CK, Gisslén M, Spudich S, Menezes P, Robertson K, Archin N, Kashuba A, Eron JJ, Price RW, Swanstrom R. Clin Infect Dis. 2019 Sep 27. PMID: 30561541.", + "Deep Sequencing Reveals Central Nervous System Compartmentalization in Multiple Transmitted/Founder Virus Acute HIV-1 Infection. Tovanabutra S, Sirijatuphat R, Pham PT, Bonar L, Harbolick EA, Bose M, Song H, Chang D, Oropeza C, O'Sullivan AM, Balinang J, Kroon E, Colby DJ, Sacdalan C, Hellmuth J, Chan P, Prueksakaew P, Pinyakorn S, Jagodzinski LL, Sutthichom D, Pattamaswin S, de Souza M, Gramzinski RA, Kim JH, Michael NL, Robb ML, Phanuphak N, Ananworanich J, Valcour V, Kijak GH, Sanders-Buell E, Spudich S. Cells. 2019 Aug 15; 2019 Aug 15. PMID: 31443253.", + "Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance. Spudich S, Robertson KR, Bosch RJ, Gandhi RT, Cyktor JC, Mar H, Macatangay BJ, Lalama CM, Rinaldo C, Collier AC, Godfrey C, Eron JJ, McMahon D, Jacobs JL, Koontz D, Hogg E, Vecchio A, Mellors JW. J Clin Invest. 2019 Jul 15; 2019 Jul 15. PMID: 31305262.", + "Switch to dolutegravir is well tolerated in Thais with HIV infection. Goh OQ, Colby DJ, Pinyakorn S, Sacdalan C, Kroon E, Chan P, Chomchey N, Kanaprach R, Prueksakaew P, Suttichom D, Trichavaroj R, Spudich S, Robb ML, Phanuphak P, Phanuphak N, Ananworanich J. J Int AIDS Soc. 2019 Jul. PMID: 31294931.", + "Slowly progressive fatal PML-IRIS following antiretroviral initiation at CD4+ nadir of 350 cells/mm(3) despite CD4+ cell count rise to 900 cells/mm(3). Sandhu MR, Rutledge R, Grant M, Mahajan A, Spudich S. Int J STD AIDS. 2019 Jul; 2019 May 2. PMID: 31046614.", + "Treatment of Central Nervous System Manifestations of HIV in the Current Era. Handoko R, Spudich S. Semin Neurol. 2019 Jun; 2019 Aug 2. PMID: 31378874.", + "Predicting Efavirenz Concentrations in the Brain Tissue of HIV-Infected Individuals and Exploring their Relationship to Neurocognitive Impairment. Srinivas N, Joseph SB, Robertson K, Kincer LP, Menezes P, Adamson L, Schauer AP, Blake KH, White N, Sykes C, Luciw P, Eron JJ, Forrest A, Price RW, Spudich S, Swanstrom R, Kashuba ADM. Clin Transl Sci. 2019 May; 2019 Feb 27. PMID: 30675981.", + "Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting. Julg B, Dee L, Ananworanich J, Barouch DH, Bar K, Caskey M, Colby DJ, Dawson L, Dong KL, Dubé K, Eron J, Frater J, Gandhi RT, Geleziunas R, Goulder P, Hanna GJ, Jefferys R, Johnston R, Kuritzkes D, Li JZ, Likhitwonnawut U, van Lunzen J, Martinez-Picado J, Miller V, Montaner LJ, Nixon DF, Palm D, Pantaleo G, Peay H, Persaud D, Salzwedel J, Salzwedel K, Schacker T, Sheikh V, Søgaard OS, Spudich S, Stephenson K, Sugarman J, Taylor J, Tebas P, Tiemessen CT, Tressler R, Weiss CD, Zheng L, Robb ML, Michael NL, Mellors JW, Deeks SG, Walker BD. Lancet HIV. 2019 Apr; 2019 Mar 15. PMID: 30885693.", + "Cerebrospinal Fluid Concentrations of the Synaptic Marker Neurogranin in Neuro-HIV and Other Neurological Disorders. Yilmaz A, Fuchs D, Price RW, Spudich S, Blennow K, Zetterberg H, Gisslén M. Curr HIV/AIDS Rep. 2019 Feb. PMID: 30649659.", + "CSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection. Gisslén M, Heslegrave A, Veleva E, Yilmaz A, Andersson LM, Hagberg L, Spudich S, Fuchs D, Price RW, Zetterberg H. Neurol Neuroimmunol Neuroinflamm. 2019 Jan; 2018 Nov 7. PMID: 30568991.", + "Residency Training: Progressive gait difficulty and incontinence in a 40-year-old man with HIV. Silverman A, O'Meara T, Le L, Robertson K, Spudich S. Neurology. 2018 Dec 4. PMID: 30510020.", + "Longitudinal Trajectories of Brain Volume and Cortical Thickness in Treated and Untreated Primary Human Immunodeficiency Virus Infection. Sanford R, Ances BM, Meyerhoff DJ, Price RW, Fuchs D, Zetterberg H, Spudich S, Collins DL. Clin Infect Dis. 2018 Nov 13. PMID: 29697762.", + "Brief Report: Safety and Tolerability of Inguinal Lymph Node Biopsy in Individuals With Acute HIV Infection in Thailand. Chintanaphol M, Sacdalan C, Chottanapund S, Pinyakorn S, Buranapraditkun S, Crowell TA, Kroon E, Manasnayakorn S, Chipman JG, Schacker TW, Michael N, Phanuphak N, Spudich SS, Colby DJ, Ananworanich J. J Acquir Immune Defic Syndr. 2018 Oct 1. PMID: 30212436.", + "Normalization of Soluble CD163 Levels After Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities. D'Antoni ML, Byron MM, Chan P, Sailasuta N, Sacdalan C, Sithinamsuwan P, Tipsuk S, Pinyakorn S, Kroon E, Slike BM, Krebs SJ, Khadka VS, Chalermchai T, Kallianpur KJ, Robb M, Spudich S, Valcour V, Ananworanich J, Ndhlovu LC. J Infect Dis. 2018 Sep 22. PMID: 29868826.", + "Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV. Farhadian SF, Mehta SS, Zografou C, Robertson K, Price RW, Pappalardo J, Chiarella J, Hafler DA, Spudich SS. JCI Insight. 2018 Sep 20; 2018 Sep 20. PMID: 30232286.", + "Distribution of Human Immunodeficiency Virus (HIV) Ribonucleic Acid in Cerebrospinal Fluid and Blood Is Linked to CD4/CD8 Ratio During Acute HIV. Chan P, Patel P, Hellmuth J, Colby DJ, Kroon E, Sacdalan C, Pinyakorn S, Jagodzinski L, Krebs S, Ananworanich J, Valcour V, Spudich S. J Infect Dis. 2018 Aug 14. PMID: 29741638.", + "Structural and functional brain imaging in acute HIV. Samboju V, Philippi CL, Chan P, Cobigo Y, Fletcher JLK, Robb M, Hellmuth J, Benjapornpong K, Dumrongpisutikul N, Pothisri M, Paul R, Ananworanich J, Spudich S, Valcour V. Neuroimage Clin. 2018; 2018 Jul 27. PMID: 30101063.", + "Central Nervous System Inflammation and Infection during Early, Nonaccelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques. Hsu DC, Sunyakumthorn P, Wegner M, Schuetz A, Silsorn D, Estes JD, Deleage C, Tomusange K, Lakhashe SK, Ruprecht RM, Lombardini E, Im-Erbsin R, Kuncharin Y, Phuang-Ngern Y, Inthawong D, Chuenarom W, Burke R, Robb ML, Ndhlovu LC, Ananworanich J, Valcour V, O'Connell RJ, Spudich S, Michael NL, Vasan S. J Virol. 2018 Jun 1; 2018 May 14. PMID: 29563297.", + "Acute Retroviral Syndrome Is Associated With High Viral Burden, CD4 Depletion, and Immune Activation in Systemic and Tissue Compartments. Crowell TA, Colby DJ, Pinyakorn S, Fletcher JLK, Kroon E, Schuetz A, Krebs SJ, Slike BM, Leyre L, Chomont N, Jagodzinski LL, Sereti I, Utay NS, Dewar R, Rerknimitr R, Chomchey N, Trichavaroj R, Valcour VG, Spudich S, Michael NL, Robb ML, Phanuphak N, Ananworanich J. Clin Infect Dis. 2018 May 2. PMID: 29228130.", + "Maps & Directions", + "Calendar", + "Contact Us", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Statistical Methods in Psychiatry and Related Fields: Longitudinal, Clustered and Other Repeated Measures Data", + "lab_url": "https://medicine.yale.edu/lab/statmethods/", + "research_bio": "INFORMATION FOR Data collected in psychiatry and related fields are complex because outcomes are rarely directly observed, there are multiple correlated repeated measures within individuals, there is natural heterogeneity in treatment responses and in other characteristics in the populations. Simple statistical methods do not work well with such data. More advanced statistical methods capture the data complexity better, but are difficult to apply appropriately and correctly by investigators who do not have advanced training in statistics. This book presents, at a non-technical level, several approaches for the analysis of correlated data: mixed models for continuous and categorical outcomes, nonparametric methods for repeated measures and growth mixture models for heterogeneous trajectories over time. Separate chapters are devoted to techniques for multiple comparison correction, analysis in the presence of missing data, adjustment for covariates, assessment of mediator and moderator effects, study design and sample size considerations. The focus is on the assumptions of each method, applicability and interpretation rather than on technical details. The intended audience are applied researchers with minimal knowledge of statistics, although the book could also benefit collaborating statisticians. The book, together with the online materials, is a valuable resource aimed at promoting the use of appropriate statistical methods for the analysis of repeated measures data. Published by CRC Press• ISBN 9781498740760", + "publications_page": "https://medicine.yale.edu/lab/statmethods/pubmed", + "publications": null + }, + { + "lab_name": "Steele Lab", + "lab_url": "https://medicine.yale.edu/lab/steele/", + "research_bio": "INFORMATION FOR Substance use disorders (SUDs), a chronic relapsing biological brain disease, affect too many people worldwide. Current treatments for SUDs are sadly insufficient to tackle this huge issue. New treatments, based on our understanding of the chronic relapsing biological nature of the disease, must be developed. The lab is positioned to bridge the translational gap between neuroimaging research and treatment of SUDs. The first step is to identify malleable circuits that could be targeted with chronic interventions. The lab uses transcranial magnetic stimulation (TMS) to modulate circuits and measures the malleability of targeted circuits with functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and event-related potentials (ERPs). We seek to work closely with treatment providers to rapidly develop and implement viable treatments for individuals with SUDs. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/steele/publications/", + "publications": [ + "Yale School of Medicine /", + "Psychiatry /", + "Research & Projects", + "Lab Members", + "Publications", + "Contact", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research & Projects", + "Lab Members", + "Publications", + "Contact", + "", + "", + "", + "", + "", + "", + "Repetitive transcranial magnetic stimulation for substance use disorders and chronic pain: A review of the evidence and call for increased mechanistic understanding. Michel A, Kang D, Fillingim RB, Balderston NL, Bond DS, Steele VR. Curr Addict Rep. 2025 Dec; 2025 Feb 7. PMID: 41019785.", + "Study protocol of a pilot randomized controlled trial of transcranial direct current stimulation paired with reappraisal training for treatment of cannabis use disorder. Stryjewski AM, Chung TJ, McCurdy LY, Spitzen TL, Zhang K, Morie KP, Steele VR, Crowley MJ, Potenza MN. PLoS One. 2025; 2025 Aug 28. PMID: 40875751.", + "Transcranial Magnetic Stimulation for Reducing Food Reinforcement in Patients Pursuing Metabolic Bariatric Surgery: A Within-Participants Sham-Controlled Pilot Trial. Bond DS, Papasavas PK, Raynor HA, Grilo CM, Wu Y, Kang D, Steele VR. Obes Surg. 2025 Aug; 2025 Jun 23. PMID: 40550967.", + "Tobacco smoking is associated with attenuated error monitoring. Stam CH, van der Veen FM, Steele VR, Franken IHA. Biol Psychol. 2025 Jul; 2025 Jun 23. PMID: 40562349.", + "Stimulating the posterior parietal cortex reduces self-reported risk-taking propensity in people with tobacco use disorder. LoFaro FM, Jordan T, Apostol MR, Steele VR, Konova AB, Petersen N. Addict Neurosci. 2024 Sep; 2024 May 31. PMID: 39329155.", + "Case report: Tremor in the placebo condition of a blinded clinical trial of intermittent theta-burst stimulation for cocaine use disorder. Steele VR, Rotenberg A, Philip NS, Hallett M, Stein EA, Salmeron BJ. Front Psychiatry. 2024; 2024 Jul 9. PMID: 39045554.", + "Functional and structural effects of repetitive transcranial magnetic stimulation (rTMS) for the treatment of auditory verbal hallucinations in schizophrenia: A systematic review. Mehta DD, Siddiqui S, Ward HB, Steele VR, Pearlson GD, George TP. Schizophr Res. 2024 May; 2024 Mar 25. PMID: 38531161.", + "Parameter Space and Potential for Biomarker Development in 25 Years of fMRI Drug Cue Reactivity: A Systematic Review. Sangchooli A, Zare-Bidoky M, Fathi Jouzdani A, Schacht J, Bjork JM, Claus ED, Prisciandaro JJ, Wilson SJ, Wüstenberg T, Potvin S, Ahmadi P, Bach P, Baldacchino A, Beck A, Brady KT, Brewer JA, Childress AR, Courtney KE, Ebrahimi M, Filbey FM, Garavan H, Ghahremani DG, Goldstein RZ, Goudriaan AE, Grodin EN, Hanlon CA, Haugg A, Heilig M, Heinz A, Holczer A, Van Holst RJ, Joseph JE, Juliano AC, Kaufman MJ, Kiefer F, Khojasteh Zonoozi A, Kuplicki RT, Leyton M, London ED, Mackey S, McClernon FJ, Mellick WH, Morley K, Noori HR, Oghabian MA, Oliver JA, Owens M, Paulus MP, Perini I, Rafei P, Ray LA, Sinha R, Smolka MN, Soleimani G, Spanagel R, Steele VR, Tapert SF, Vollstädt-Klein S, Wetherill RR, Witkiewitz K, Yuan K, Zhang X, Verdejo-Garcia A, Potenza MN, Janes AC, Kober H, Zilverstand A, Ekhtiari H. JAMA Psychiatry. 2024 Apr 1. PMID: 38324323.", + "A systematic review and meta-analysis of neuromodulation therapies for substance use disorders. Mehta DD, Praecht A, Ward HB, Sanches M, Sorkhou M, Tang VM, Steele VR, Hanlon CA, George TP. Neuropsychopharmacology. 2024 Mar; 2023 Dec 12. PMID: 38086901.", + "Editorial: New discoveries in the field of brain stimulation and addiction disorders. Kang D, Baker TE, Steele VR. Front Neurosci. 2023; 2023 Nov 29. PMID: 38094005.", + "Transcranial Magnetic Stimulation for Reducing the Relative Reinforcing Value of Food in Adult Patients With Obesity Pursuing Metabolic and Bariatric Surgery: Protocol for a Pilot, Within-Participants, Sham-Controlled Trial. Bond DS, Papasavas PK, Raynor HA, Grilo CM, Steele VR. JMIR Res Protoc. 2023 Nov 6; 2023 Nov 6. PMID: 37930756.", + "A methodological checklist for fMRI drug cue reactivity studies: development and expert consensus. Ekhtiari H, Zare-Bidoky M, Sangchooli A, Janes AC, Kaufman MJ, Oliver JA, Prisciandaro JJ, Wüstenberg T, Anton RF, Bach P, Baldacchino A, Beck A, Bjork JM, Brewer J, Childress AR, Claus ED, Courtney KE, Ebrahimi M, Filbey FM, Ghahremani DG, Azbari PG, Goldstein RZ, Goudriaan AE, Grodin EN, Hamilton JP, Hanlon CA, Hassani-Abharian P, Heinz A, Joseph JE, Kiefer F, Zonoozi AK, Kober H, Kuplicki R, Li Q, London ED, McClernon J, Noori HR, Owens MM, Paulus MP, Perini I, Potenza M, Potvin S, Ray L, Schacht JP, Seo D, Sinha R, Smolka MN, Spanagel R, Steele VR, Stein EA, Steins-Loeber S, Tapert SF, Verdejo-Garcia A, Vollstädt-Klein S, Wetherill RR, Wilson SJ, Witkiewitz K, Yuan K, Zhang X, Zilverstand A. Nat Protoc. 2022 Mar; 2022 Feb 4. PMID: 35121856.", + "Neuromodulation to Treat Substance Use Disorders in People With Schizophrenia and Other Psychoses: A Systematic Review. Johnstone S, Sorkhou M, Al-Saghir N, Lowe DJE, Steele VR, Pearlson GD, Castle DJ, George TP. Front Psychiatry. 2022; 2022 Feb 14. PMID: 35237187.", + "Phonological processing in psychopathic offenders. Montry KM, Simmonite M, Steele VR, Brook MA, Kiehl KA, Kosson DS. Int J Psychophysiol. 2021 Oct; 2021 Aug 3. PMID: 34358580.", + "Treating cocaine and opioid use disorder with transcranial magnetic stimulation: A path forward. Steele VR, Maxwell AM. Pharmacol Biochem Behav. 2021 Oct; 2021 Jul 21. PMID: 34298030.", + "A Circuit-Based Approach to Treating Substance Use Disorders With Noninvasive Brain Stimulation. Steele VR. Biol Psychiatry. 2021 May 15. PMID: 33958035.", + "Transcranial Magnetic Stimulation as an Interventional Tool for Addiction. Steele VR. Front Neurosci. 2020; 2020 Oct 22. PMID: 33192278.", + "Transcranial magnetic stimulation and addiction: Toward uncovering known unknowns. Steele VR. EBioMedicine. 2020 Jul; 2020 Jul 3. PMID: 32629385.", + "Repetitive Transcranial Magnetic Stimulation Delivered With an H-Coil to the Right Insula Reduces Functional Connectivity Between Insula and Medial Prefrontal Cortex. Lee MR, Caparelli EC, Leff M, Steele VR, Maxwell AM, McCullough K, Salmeron BJ. Neuromodulation. 2020 Apr; 2019 Oct 23. PMID: 31645087.", + "Adolescent Psychopathic Traits Negatively Relate to Hemodynamic Activity within the Basal Ganglia during Error-Related Processing. Maurer JM, Steele VR, Vincent GM, Rao V, Calhoun VD, Kiehl KA. J Abnorm Child Psychol. 2019 Dec. PMID: 31104203.", + "Accelerated Intermittent Theta-Burst Stimulation as a Treatment for Cocaine Use Disorder: A Proof-of-Concept Study. Steele VR, Maxwell AM, Ross TJ, Stein EA, Salmeron BJ. Front Neurosci. 2019; 2019 Oct 30. PMID: 31736689.", + "Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders. Liu Y, van den Wildenberg WPM, de Graaf Y, Ames SL, Baldacchino A, Bø R, Cadaveira F, Campanella S, Christiansen P, Claus ED, Colzato LS, Filbey FM, Foxe JJ, Garavan H, Hendershot CS, Hester R, Jester JM, Karoly HC, Kräplin A, Kreusch F, Landrø NI, Littel M, Loeber S, London ED, López-Caneda E, Lubman DI, Luijten M, Marczinski CA, Metrik J, Montgomery C, Papachristou H, Mi Park S, Paz AL, Petit G, Prisciandaro JJ, Quednow BB, Ray LA, Roberts CA, Roberts GMP, de Ruiter MB, Rupp CI, Steele VR, Sun D, Takagi M, Tapert SF, van Holst RJ, Verdejo-Garcia A, Vonmoos M, Wojnar M, Yao Y, Yücel M, Zack M, Zucker RA, Huizenga HM, Wiers RW. Neurosci Biobehav Rev. 2019 Oct; 2019 Jul 15. PMID: 31319124.", + "Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead. Ekhtiari H, Tavakoli H, Addolorato G, Baeken C, Bonci A, Campanella S, Castelo-Branco L, Challet-Bouju G, Clark VP, Claus E, Dannon PN, Del Felice A, den Uyl T, Diana M, di Giannantonio M, Fedota JR, Fitzgerald P, Gallimberti L, Grall-Bronnec M, Herremans SC, Herrmann MJ, Jamil A, Khedr E, Kouimtsidis C, Kozak K, Krupitsky E, Lamm C, Lechner WV, Madeo G, Malmir N, Martinotti G, McDonald WM, Montemitro C, Nakamura-Palacios EM, Nasehi M, Noël X, Nosratabadi M, Paulus M, Pettorruso M, Pradhan B, Praharaj SK, Rafferty H, Sahlem G, Salmeron BJ, Sauvaget A, Schluter RS, Sergiou C, Shahbabaie A, Sheffer C, Spagnolo PA, Steele VR, Yuan TF, van Dongen JDM, Van Waes V, Venkatasubramanian G, Verdejo-García A, Verveer I, Welsh JW, Wesley MJ, Witkiewitz K, Yavari F, Zarrindast MR, Zawertailo L, Zhang X, Cha YH, George TP, Frohlich F, Goudriaan AE, Fecteau S, Daughters SB, Stein EA, Fregni F, Nitsche MA, Zangen A, Bikson M, Hanlon CA. Neurosci Biobehav Rev. 2019 Sep; 2019 Jul 2. PMID: 31271802.", + "Toward an integrative perspective on the neural mechanisms underlying persistent maladaptive behaviors. Diehl MM, Lempert KM, Parr AC, Ballard I, Steele VR, Smith DV. Eur J Neurosci. 2018 Aug; 2018 Aug 20. PMID: 30044022.", + "Age of gray matters: Neuroprediction of recidivism. Kiehl KA, Anderson NE, Aharoni E, Maurer JM, Harenski KA, Rao V, Claus ED, Harenski C, Koenigs M, Decety J, Kosson D, Wager TD, Calhoun VD, Steele VR. Neuroimage Clin. 2018; 2018 Jun 3. PMID: 30013925.", + "Psychopathic traits associated with abnormal hemodynamic activity in salience and default mode networks during auditory oddball task. Anderson NE, Maurer JM, Steele VR, Kiehl KA. Cogn Affect Behav Neurosci. 2018 Jun. PMID: 29633199.", + "Report of transient events in a cocaine-dependent volunteer who received iTBS. Steele VR, Maxwell AM, Ross TJ, Moussawi K, Abulseoud OO, Stein EA, Salmeron BJ. Brain Stimul. 2018 May-Jun; 2018 Jan 31. PMID: 29429954.", + "Machine Learning of Functional Magnetic Resonance Imaging Network Connectivity Predicts Substance Abuse Treatment Completion. Steele VR, Maurer JM, Arbabshirani MR, Claus ED, Fink BC, Rao V, Calhoun VD, Kiehl KA. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Feb; 2017 Aug 1. PMID: 29529409.", + "Investigating error-related processing in incarcerated adolescents with self-report psychopathy measures. Maurer JM, Steele VR, Fink BC, Vincent GM, Calhoun VD, Kiehl KA. Biol Psychol. 2018 Feb; 2017 Nov 24. PMID: 29180243.", + "Differentiating emotional processing and attention in psychopathy with functional neuroimaging. Anderson NE, Steele VR, Maurer JM, Rao V, Koenigs MR, Decety J, Kosson DS, Calhoun VD, Kiehl KA. Cogn Affect Behav Neurosci. 2017 Jun. PMID: 28092055.", + "Machine learning of structural magnetic resonance imaging predicts psychopathic traits in adolescent offenders. Steele VR, Rao V, Calhoun VD, Kiehl KA. Neuroimage. 2017 Jan 15; 2015 Dec 12. PMID: 26690808.", + "Prause et al. (2015) the latest falsification of addiction predictions. Prause N, Steele VR, Staley C, Sabatinelli D, Hajcak G. Biol Psychol. 2016 Oct; 2016 Jun 16. PMID: 27318185.", + "Brain potentials predict substance abuse treatment completion in a prison sample. Fink BC, Steele VR, Maurer MJ, Fede SJ, Calhoun VD, Kiehl KA. Brain Behav. 2016 Aug; 2016 May 31. PMID: 27547503.", + "Dysfunctional error-related processing in female psychopathy. Maurer JM, Steele VR, Edwards BG, Bernat EM, Calhoun VD, Kiehl KA. Soc Cogn Affect Neurosci. 2016 Jul; 2015 Jun 8. PMID: 26060326.", + "Dysfunctional error-related processing in incarcerated youth with elevated psychopathic traits. Maurer JM, Steele VR, Cope LM, Vincent GM, Stephen JM, Calhoun VD, Kiehl KA. Dev Cogn Neurosci. 2016 Jun; 2016 Feb 22. PMID: 26930170.", + "Neuroimaging measures of error-processing: Extracting reliable signals from event-related potentials and functional magnetic resonance imaging. Steele VR, Anderson NE, Claus ED, Bernat EM, Rao V, Assaf M, Pearlson GD, Calhoun VD, Kiehl KA. Neuroimage. 2016 May 15; 2016 Feb 22. PMID: 26908319.", + "Error-related processing in adult males with elevated psychopathic traits. Steele VR, Maurer JM, Bernat EM, Calhoun VD, Kiehl KA. Personal Disord. 2016 Jan; 2015 Oct 19. PMID: 26479259.", + "Abnormal frontostriatal activity in recently abstinent cocaine users during implicit moral processing. Caldwell BM, Harenski CL, Harenski KA, Fede SJ, Steele VR, Koenigs MR, Kiehl KA. Front Hum Neurosci. 2015; 2015 Oct 16. PMID: 26528169.", + "Psychopathy, attention, and oddball target detection: New insights from PCL-R facet scores. Anderson NE, Steele VR, Maurer JM, Bernat EM, Kiehl KA. Psychophysiology. 2015 Sep; 2015 Apr 24. PMID: 25912522.", + "Multimodal imaging measures predict rearrest. Steele VR, Claus ED, Aharoni E, Vincent GM, Calhoun VD, Kiehl KA. Front Hum Neurosci. 2015; 2015 Aug 3. PMID: 26283947.", + "Modulation of late positive potentials by sexual images in problem users and controls inconsistent with \"porn addiction\". Prause N, Steele VR, Staley C, Sabatinelli D, Hajcak G. Biol Psychol. 2015 Jul; 2015 Jun 18. PMID: 26095441.", + "Separability of abstract-category and specific-exemplar visual object subsystems: evidence from fMRI pattern analysis. McMenamin BW, Deason RG, Steele VR, Koutstaal W, Marsolek CJ. Brain Cogn. 2015 Feb; 2014 Dec 18. PMID: 25528436.", + "The relationship between somatic and cognitive-affective depression symptoms and error-related ERPs. Bridwell DA, Steele VR, Maurer JM, Kiehl KA, Calhoun VD. J Affect Disord. 2015 Feb 1; 2014 Oct 12. PMID: 25451400.", + "Late positive potential to explicit sexual images associated with the number of sexual intercourse partners. Prause N, Steele VR, Staley C, Sabatinelli D. Soc Cogn Affect Neurosci. 2015 Jan; 2014 Feb 12. PMID: 24526189.", + "A large scale (N=102) functional neuroimaging study of error processing in a Go/NoGo task. Steele VR, Claus ED, Aharoni E, Harenski C, Calhoun VD, Pearlson G, Kiehl KA. Behav Brain Res. 2014 Jul 15; 2014 Apr 12. PMID: 24726752.", + "Brain potentials measured during a Go/NoGo task predict completion of substance abuse treatment. Steele VR, Fink BC, Maurer JM, Arbabshirani MR, Wilber CH, Jaffe AJ, Sidz A, Pearlson GD, Calhoun VD, Clark VP, Kiehl KA. Biol Psychiatry. 2014 Jul 1; 2013 Oct 11. PMID: 24238783.", + "Abnormal brain structure in youth who commit homicide. Cope LM, Ermer E, Gaudet LM, Steele VR, Eckhardt AL, Arbabshirani MR, Caldwell MF, Calhoun VD, Kiehl KA. Neuroimage Clin. 2014; 2014 May 10. PMID: 24936430.", + "Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors. Murray EJ, Crowley RC, Truman A, Clarke SR, Cottam JA, Jadhav GP, Steele VR, O'Shea P, Lindholm C, Cockayne A, Chhabra SR, Chan WC, Williams P. J Med Chem. 2014 Mar 27; 2014 Mar 13. PMID: 24592914.", + "A large scale (N=102) functional neuroimaging study of response inhibition in a Go/NoGo task. Steele VR, Aharoni E, Munro GE, Calhoun VD, Nyalakanti P, Stevens MC, Pearlson G, Kiehl KA. Behav Brain Res. 2013 Nov 1; 2013 Jun 10. PMID: 23756137.", + "Sexual desire, not hypersexuality, is related to neurophysiological responses elicited by sexual images. Steele VR, Staley C, Fong T, Prause N. Socioaffect Neurosci Psychol. 2013; 2013 Jul 16. PMID: 24693355.", + "Separable processes before, during, and after the N400 elicited by previously inferred and new information: evidence from time-frequency decompositions. Steele VR, Bernat EM, van den Broek P, Collins PF, Patrick CJ, Marsolek CJ. Brain Res. 2013 Jan 25; 2012 Nov 16. PMID: 23165117.", + "Externalizing psychopathology and gain-loss feedback in a simulated gambling task: dissociable components of brain response revealed by time-frequency analysis. Bernat EM, Nelson LD, Steele VR, Gehring WJ, Patrick CJ. J Abnorm Psychol. 2011 May. PMID: 21319875.", + "Multiple essential roles for EzrA in cell division of Staphylococcus aureus. Steele VR, Bottomley AL, Garcia-Lara J, Kasturiarachchi J, Foster SJ. Mol Microbiol. 2011 Apr; 2011 Mar 14. PMID: 21401734.", + "Identifying objects impairs knowledge of other objects: a relearning explanation for the neural repetition effect. Marsolek CJ, Deason RG, Ketz NA, Ramanathan P, Bernat EM, Steele VR, Patrick CJ, Verfaellie M, Schnyer DM. Neuroimage. 2010 Jan 15; 2009 Sep 8. PMID: 19744565.", + "Verbal memory processes in schizophrenia patients and biological relatives of schizophrenia patients: intact implicit memory, impaired explicit recollection. Sponheim SR, Steele VR, McGuire KA. Schizophr Res. 2004 Dec 1. PMID: 15474904.", + "Steele, V. R., Pariyadath, V., Goldstein, R. Z., & Stein, E. A. (2018). Reward Circuitry and Drug Addiction. In D.S. Charney, P. Sklar, J.D. Buxbaum, & E. J. Nestler (Ed.) Neurobiology of Mental Illness (pp. 587- 600). Oxford University Press.", + "Steele, V. R., Ding, X., & Ross, T. J. (2019). Addiction: Informing drug abuse interventions with brain networks. In B.C. Munsell, G. Wu, L. Bonilha, & P.J. Laurienti (Ed.) Connectomics: Applications to Neuroimaging (pp. 101-123). Elsevier.", + "vaughn.steele@yale.edu", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Steitz Lab", + "lab_url": "https://medicine.yale.edu/lab/steitz/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/steitz/publications/", + "publications": null + }, + { + "lab_name": "Stern Lab", + "lab_url": "https://medicine.yale.edu/lab/stern/", + "research_bio": "INFORMATION FOR Copy Link Human cancer is caused by genetic and epigenetic changes that alter hormone-regulated signal transduction pathways, leading to growth dysregulation, and that alter protective responses to DNA damage, leading to genomic instability. The Stern laboratory investigates processes that represent each of these major categories. The goals of this work are better understanding of the underlying causes of human cancer and linkage of this understanding to therapeutic applications. To read more about our research, please see theStern Lab Researchpage for the Stern Lab. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/stern/publications/", + "publications": null + }, + { + "lab_name": "Strittmatter Laboratory", + "lab_url": "https://medicine.yale.edu/lab/strittmatter/", + "research_bio": "INFORMATION FOR Copy Link Neurological injury frequently interrupts connections while sparing nerve cells themselves. Spinal cord injury (SCI) is the epitome of a disconnection syndrome, in which surviving neural tissue fails to function due to lost communication above and below the level of injury. For the organism to regain function, new pathways must form by growth of cut or surviving nerve fibers. Unfortunately, the growth of axons and the rearrangement of brain circuity are extremely limited in the adult brain and spinal cord. We focus on understanding the molecular pathways that limit fiber growth and functional rewiring of neuronal circuits during health and disease. Axonal growth encompasses both neural plasticity and repair. Technically, we utilize chronic in vivo imaging of neuronal connections, genetic alteration of mice, and induction of surgical lesions resembling clinical SCI and stroke. In particular, we have found that the Nogo Receptor (NgR1) pathway mediating myelin inhibition of axonal growth plays a role in titrating anatomical plasticity in the adults CNS. In Alzheimer's disease and several other neurodegenerative conditions, nerve cells are lost over time. Molecular contributors to this pathology have been discovered by genetic methods, but their mechanism of action has remained poorly understood. We have focused on defining the pathophysiological action of Amyloid-beta (Aß) peptide oligomers in Alzheimer's disease, and on the role of secreted Progranulin in Fronto-Temporal Dementia. For both of these molecules, interaction with the specific receptors on the neuronal surface is crucial. We utilize receptor ligand binding assays, expression cloning, electrophysiology, mouse genetics, and mouse behavior to study these pathways. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Structural Health and Psychology (SHP) Lab", + "lab_url": "https://medicine.yale.edu/lab/shl/", + "research_bio": "INFORMATION FOR Copy Link How do we know if a politician is gaslighting us? Robin Stern and Marc Brackett give us five things to look out for as we navigate this fall's political landscape.", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Study of Trauma, Addiction, and Recovery Lab", + "lab_url": "https://medicine.yale.edu/lab/starlab/", + "research_bio": "INFORMATION FOR Housed within the Division of Prevention and Community Research, the Study of Trauma, Addiction, and Recovery (STAR) Lab is dedicated to understanding how trauma and emotional processes influence substance use in people’s real-world, daily lives. Our research focuses on individuals who have experienced trauma, with a particular emphasis on those living with posttraumatic stress disorder (PTSD) and substance use disorders. These individuals often face more severe emotional and behavioral challenges, including greater functional impairment, more intense PTSD symptoms, and more harmful patterns of substance use. In the STAR Lab, we use a combination of real-time, self-reported and sensor-based data to explore how emotions unfold throughout the day- and how these emotional patterns may increase risk for substance use. Through this, our goal is to uncover new insights into the emotional roots of addiction and recovery. Through this work, we aim to inform more responsive, real-world interventions and promote long-term wellness in trauma-exposed communities. The Consultation Center • 389 Whitney Avenue • New Haven, CT 06489 Copy Link", + "publications_page": "https://medicine.yale.edu/lab/starlab/publications/", + "publications": null + }, + { + "lab_name": "Sukhodolsky Lab", + "lab_url": "https://medicine.yale.edu/lab/sukhodolsky/", + "research_bio": "INFORMATION FOR The Sukhodolsky Lab conducts research on behavioral treatments for children with autism spectrum disorder, Tourette syndrome, OCD, anxiety, and disruptive behavior disorders. We investigate how well different behavioral therapies work and how they change the brain. We are currently studying cognitive behavioral therapy (CBT) for anxiety in children with autism spectrum disorder (ASD), CBT for irritability and aggression in adolescents with ASD, adolescent and adult transitions in ASD, and fMRI neurofeedback treatment for OCD. Other interventions we have studied include CBT for anger and aggression in children, parent training for disruptive behavior in children with ASD, behavior therapy for tics, and digital parent training for young children with disruptive behavior. The Sukhodolsky Lab is led by Denis Sukhodolsky, PhD, Associate Professor in the Child Study Center On a warm spring day, Rayford Bromley, 13, sprawled on a bench in the Yale Child Study Center, chatting about school, his friends, and a bonfire he had been invited to attend. This was a big change from just a few months ago. Anxious and withdrawn, Rafe had been struggling, wanting to make friends but not knowing how to go about it. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/sukhodolsky/publications", + "publications": null + }, + { + "lab_name": "Sullivan Lab - Family Violence Research", + "lab_url": "https://medicine.yale.edu/lab/sullivan/", + "research_bio": "INFORMATION FOR The Family Violence Research Lab at Yale School of Medicine gathered on October 13, 2025, to wear purple in recognition of Domestic Violence Awareness Month—a national campaign established by Congress in 1989 to raise awareness about domestic violence and uplift survivor voices and experiences. This year's theme, \"With Survivors, Always,\" underscores the importance of centering survivor needs and experiences in our research and community efforts. Dr. Tami Sullivan, bottom row, middle, Professor of Psychiatry and Director of the Family Violence Research and Programs, and her team are dedicated to advancing research on domestic violence. The lab's research aims to promote survivor safety, recovery, and resilience. One in two women in the United States experiences severe psychological, physical, or sexual abuse in their lifetime. Participating lab members are, bottom row, from left, Ana Hernandez, BS, Tami Sullivan, PhD, and Alexandra Torres Arsuaga, BA; middle row, from left, Marley Herard, MA, Laura Callinan, MPH and Alexandrya Pope, LMSW, MSW, MS; top row, from left, Ashley Clayton, MA and Melissa Schick, PhD. Our program of research is centered on individual- and system-level factors that affect the mental and physical health of women who experience intimate partner violence (IPV). At the individual level, we conduct risk and protective factor research with a focus on applying micro-longitudinal designs such as experience sampling methods and research that informs the development of interventions to be implemented in community settings. Specifically, we examine At the system-level, our research focuses on understanding the capacity of systems (e.g., criminal justice system and HIV service system) to meet the unique needs of women who experience IPV and how these systems influence the wellbeing of women. For example, a current study is examining the extent to which criminal orders of protection reduce domestic violence and influence the daily lives of women experiencing intimate partner violence, their offenders’ behavior, and their children’s wellbeing. In addition to conducting federally-funded research, we are a statewide leader in the delivery of violence prevention services to adult aggressors of domestic violence. Our staff develops and implements psychoeducational groups for men and women to address domestic violence, and as appropriate, anger management. Further, we consult to programs and service systems regarding meeting the unique needs of populations affected by domestic violence. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/sullivan/pubs", + "publications": [ + "Yale School of Medicine /", + "Psychiatry /", + "Research Family Violence Education Program Violence, PTSD & Substance Use Partner Violence & Drug Use Relationship Stress Study Women's Violence in Relationships Criminal Protection Orders Researcher-Practitioner Partnership", + "Family Violence Education Program", + "Violence, PTSD & Substance Use", + "Partner Violence & Drug Use", + "Relationship Stress Study", + "Women's Violence in Relationships", + "Criminal Protection Orders", + "Researcher-Practitioner Partnership", + "Contact Us", + "Lab Members Collaborators", + "Collaborators", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Lab Members", + "Publications", + "News", + "Contact Us", + "", + "", + "", + "", + "", + "", + "Emotion dysregulation modulates the relation between emotional intensity and biological stress dysregulation among community women experiencing intimate partner violence. Weiss NH, Schick MR, Scheer JR, Stamates AL, Raudales AM, Kiefer R, Contractor AA, Sullivan TP. Psychoneuroendocrinology. 2025 Dec; 2025 Sep 27. PMID: 41067057.", + "Comparing Fathers for Change Individual Therapy for IPV Use to the Duluth Model Intervention in Individual and Group Formats. Stover CS, Shayani DR, Ramos KL, Sullivan TP, Hayes A. J Interpers Violence. 2025 Oct 4; 2025 Oct 4. PMID: 41045209.", + "The Nature of Explicit and Implicit Firearm Threat by Intimate Partners Across the Life Course among Women Experiencing Intimate Partner Violence. Sullivan TP, Clayton A, Schick MR, Maxwell CD, Mastalli-Lowther G, O'Neil-Wild G, Scanlon MD. Psychol Violence. 2025 Sep; 2025 Mar 20. PMID: 40969784.", + "Drought, Extreme Heat, and Intimate Partner Violence in Low- and Middle-Income Countries. Wang P, Chu L, Ban J, Asare EO, Sivakami M, Henao AR, Chimoyi L, Sullivan TP, Chen K. JAMA Netw Open. 2025 Aug 1; 2025 Aug 1. PMID: 40833696.", + "Elucidating Heterogeneity of Intimate Partner Violence Among Women: Latent Class Analysis of Daily IPV, PTSD, and Substance Use Collected via Experience Sampling Methodologies. Chiaramonte D, Schick MR, Woerner J, Hernandez AJ, Sullivan TP. J Interpers Violence. 2025 Aug; 2024 Oct 24. PMID: 39445476.", + "Patterns of substance-involved intimate partner violence perpetration: Findings from a daily diary study. Schick MR, Clayton A, Maxwell CD, Sullivan TP. Addict Behav. 2025 Jul; 2025 Feb 21. PMID: 40049052.", + "Examining concordance between emotion-dependent risk-taking in the laboratory and in the real-world. Weiss NH, Schick MR, Raudales AM, Thomas ED, Ho D, Goldstein SC, Kiefer R, Newberger NG, Contractor AA, Sullivan TP. Behav Res Ther. 2025 Apr; 2025 Feb 25. PMID: 40037003.", + "Daily minority stressors, threat appraisal, and identity concealment among trauma-exposed sexual minority women and transgender and gender-diverse people. Scheer JR, Jackson SD, Cascalheira CJ, Behari K, Helminen EC, Batchelder AW, Sullivan TP. J Couns Psychol. 2025 Apr; 2025 Feb 10. PMID: 39928459.", + "Yes stormtrooper, these are the droids you are looking for: Identifying and preliminarily evaluating bot and fraud detection strategies in online psychological research. Shaw TJ, Cascalheira CJ, Helminen EC, Brisbin CD, Jackson SD, Simone M, Sullivan TP, Batchelder AW, Scheer JR. Psychol Methods. 2025 Mar 3; 2025 Mar 3. PMID: 40029298.", + "Measuring emotion dysregulation in daily life: an experience sampling study. Weiss NH, Dixon-Gordon KL, Brick LA, Goldstein SC, Schick MR, Laws H, Kiefer R, Contractor AA, Sullivan TP. Anxiety Stress Coping. 2025 Jan; 2024 Jun 27. PMID: 38932637.", + "A psychometric evaluation of the PTSD Checklist for DSM-5 among women experiencing intimate partner violence. Schick MR, Sullivan TP, Alfano AR, Weiss NH. J Trauma Stress. 2024 Dec; 2024 Jul 19. PMID: 39031171.", + "Examining Daily Self-Efficacy, Minority Stressors, and Alcohol and Other Drug Use Among Trauma-Exposed Sexual Minority Women and Transgender and Gender-Diverse People. Scheer JR, Mereish EH, Gilmore AK, Cascalheira CJ, Helminen EC, Dobani F, Behari K, Pirog S, Jackson SD, Sullivan TP, Batchelder AW. Ann Behav Med. 2024 Nov 16. PMID: 39402938.", + "Patterns of Family Conflict and Accusations of Abuse in Dementia Family Caregivers: A Latent Class Analysis. Browning WR, Yildiz M, Maxwell CD, Sullivan TP, Yefimova M, Hernandez Chilatra JA, Pickering CEZ. Gerontologist. 2024 Oct 1. PMID: 39166288.", + "Predicting Completion of Ecological Momentary Assessments Among Substance-Using Women Experiencing Intimate Partner Violence. Yang M, Schick MR, Sullivan TP, Weiss NH. Assessment. 2024 Oct; 2024 Jan 4. PMID: 38174693.", + "Mechanisms Underlying the Use of Abusive and Neglectful Behaviors in Dementia Caregiving: The Role of Caregiver Mental Health. Browning WR, Yildiz M, Hernandez Chilatra JA, Yefimova M, Maxwell CD, Sullivan TP, Winstead V, Pickering CEZ. Res Gerontol Nurs. 2024 Sep-Oct; 2024 Sep 1. PMID: 39347758.", + "Impact of COVID-19 on women living with HIV who are survivors of intimate partner violence. Zhang X, Price CR, Pope AS, Sullivan TP, Meyer JP. BMC Public Health. 2024 May 20; 2024 May 20. PMID: 38769576.", + "Emotion Regulation, Coping Strategies, and Hazardous Drinking Among Family Caregivers of People With Alzheimer's Disease and Related Dementias. Hernandez Chilatra JA, Browning WR, Yildiz M, Sullivan TP, Pickering CE. Res Gerontol Nurs. 2024 Mar-Apr; 2024 Mar 1. PMID: 38507290.", + "Concordance of Posttraumatic Stress Disorder Symptoms Assessed via Retrospective Report Versus Experience Sampling Methods in Community Women Experiencing Intimate Partner Violence. Kiefer R, Schick MR, Newberger NG, Ferguson JJ, Raudales AM, Sullivan TP, Weiss NH. J Interpers Violence. 2024 Feb; 2023 Sep 14. PMID: 37706478.", + "Criminal orders of protection for survivors of intimate partner violence, future system engagement, and well-being: Understanding the importance of prior abusive relationships. Woerner J, Sullivan TP, Cattaneo LB, Backes BL, Bellucci B. Vict Offender. 2024; 2023 May 17. PMID: 39184826.", + "Expressive writing treatments to reduce PTSD symptom severity and negative alcohol-related outcomes among trauma-exposed sexual minority women and transgender/nonbinary people: Study protocol for a mixed-method pilot trial. Scheer JR, Behari K, Schwarz AA, Cascalheira CJ, Helminen EC, Pirog SA, Jaipuriyar V, Sullivan TP, Batchelder AW, Jackson SD. Contemp Clin Trials Commun. 2023 Oct; 2023 Aug 21. PMID: 37671246.", + "Intimate Partner Violence Survivors' Daily Experiences of Social Disconnection, Substance Use, and Sex with Secondary Partners. Woerner J, Chiaramonte D, Clark DA, Tennen H, Sullivan TP. Prev Sci. 2023 Oct; 2023 May 27. PMID: 37243866.", + "Ecological investigation of the co-occurrence of posttraumatic stress disorder symptoms and cannabis use among community women experiencing intimate partner violence. Newberger NG, Forkus SR, Thomas ED, Goldstein SC, Ferguson JJ, Sullivan TP, Weiss NH. Drug Alcohol Depend. 2023 Sep 1; 2023 Jul 22. PMID: 37515827.", + "\"I Know Myself Again, Which Makes Me Motivated for Life\": Feasibility and Acceptability of Using Experience Sampling Methods With Trauma-Exposed Sexual Minority Women. Scheer JR, Cascalheira CJ, Helminen EC, Shaw TJ, Schwarz AA, Jaipuriar V, Brisbin CD, Batchelder AW, Sullivan TP, Jackson SD. J Interpers Violence. 2023 Jul; 2023 Feb 15. PMID: 36789733.", + "Probable PTSD, PTSD symptom severity, and comorbid PTSD and hazardous drinking among sexual minority women compared to heterosexual women: A meta-analysis. Scheer JR, Helminen EC, Cascalheira CJ, Jaipuriyar V, Shaw TJ, Zabelski S, Behari K, Pirog S, Batchelder AW, Possemato K, Hughes TL, Sullivan TP. Clin Psychol Rev. 2023 Jun; 2023 Apr 23. PMID: 37150043.", + "Experimental Investigation of the Influence of Positive Emotion Dysregulation on Risky Behavior Following Idiographic Emotion Inductions. Weiss NH, Schick MR, Raudales AM, Forkus SR, Thomas ED, Contractor AA, Sullivan TP. Clin Psychol Sci. 2023 May; 2023 Jan 10. PMID: 37576546.", + "PTSD Symptoms and Hazardous Drinking Indicators among Trauma-Exposed Sexual Minority Women during Heightened Societal Stress. Helminen EC, Scheer JR, Jackson SD, Brisbin CD, Batchelder AW, Cascalheira CJ, Sullivan TP. Behav Med. 2023 Apr-Jun; 2021 Dec 6. PMID: 34870567.", + "Intimate Partner Violence and Mental Health Outcomes Among Hispanic Women in the United States: A Scoping Review. Reyes ME, Simpson L, Sullivan TP, Contractor AA, Weiss NH. Trauma Violence Abuse. 2023 Apr; 2021 Nov 14. PMID: 34779327.", + "Intimate Partner Violence Fear-11 Scale: An Item Response Analysis. Sullivan TP, Chiaramonte D, Clark DA, Swan S. Psychol Violence. 2023 Mar; 2022 Jun 30. PMID: 37065535.", + "Posttraumatic stress as a moderator of the association between HPA-axis functioning and alcohol use disorder among a community sample of women currently experiencing intimate partner violence. Goldstein SC, Schick MR, Weyandt LL, Sullivan TP, Saint-Eloi Cadely H, Weiss NH. Exp Clin Psychopharmacol. 2023 Feb; 2022 Feb 3. PMID: 35113644.", + "Associations among Intimate Partner Violence, Posttraumatic Stress Disorder Symptoms, and Disordered Eating among Women Intimate Partner Violence Survivors Residing in Shelter. Holmes SC, King KC, Gonzalez A, Norton MK, Silver KE, Sullivan TP, Johnson DM. J Interpers Violence. 2023 Jan; 2022 May 10. PMID: 35536767.", + "Posttraumatic stress disorder strengthens the momentary associations between emotion dysregulation and substance use: a micro-longitudinal study of community women experiencing intimate partner violence. Weiss NH, Brick LA, Schick MR, Forkus SR, Raudales AM, Contractor AA, Sullivan TP. Addiction. 2022 Dec; 2022 Jul 25. PMID: 35792057.", + "Criminal Protection Orders: Implications of Requested Versus Issued Orders on Domestic Violence Revictimiztion and Mental Health Among Women. Sullivan TP, Weiss NH, Woerner J, Belliveau D. J Interpers Violence. 2022 Oct; 2021 Aug 3. PMID: 34344213.", + "Criminal Protection Orders Among Women Victims of Intimate Partner Violence: Women's Experiences of Court Decisions, Processes, and Their Willingness to Engage With the System in the Future. Holmes SC, Maxwell CD, Cattaneo LB, Bellucci BA, Sullivan TP. J Interpers Violence. 2022 Sep; 2021 Jun 16. PMID: 34130534.", + "Modeling reciprocal relations between emotion dysregulation and alcohol use using dynamic structural equation modeling: A micro-longitudinal study. Weiss NH, Brick LA, Forkus SR, Goldstein SC, Thomas ED, Schick MR, Barnett NP, Contractor AA, Sullivan TP. Alcohol Clin Exp Res. 2022 Aug; 2022 Jun 22. PMID: 35676805.", + "Intimate Partner Violence and Posttraumatic Stress Symptoms: Indirect Effects Through Negative and Positive Emotion Dysregulation. Simpson LE, Raudales AM, Reyes ME, Sullivan TP, Weiss NH. J Interpers Violence. 2022 Aug; 2021 Apr 15. PMID: 33858266.", + "The Role of Acculturation in the Relation Between Intimate Partner Violence and Substance Misuse Among IPV-victimized Hispanic Women in the Community. Reyes ME, Weiss NH, Swan SC, Sullivan TP. J Interpers Violence. 2022 May; 2020 Oct 24. PMID: 33100128.", + "Racial/Ethnic Differences in Alcohol and Drug Misuse Among IPV-Victimized Women: Exploring the Role of Difficulties Regulating Positive Emotions. Weiss NH, Schick MR, Contractor AA, Reyes ME, Suazo NC, Sullivan TP. J Interpers Violence. 2022 Mar; 2020 Jul 22. PMID: 32697115.", + "Alcohol Misuse and Women's Use of Aggression in Intimate Relationships: The Mediating Role of Motivations for Using Aggression. Nelson-Aguiar RJ, Weiss NH, Swan SC, Sullivan TP. J Interpers Violence. 2022 Mar; 2020 Jul 9. PMID: 32644858.", + "The Association Between Demographic, Mental Health, and Intimate Partner Violence Victimization Variables and Undergraduate Women's Intimate Partner Violence Perpetration. Holmes SC, Johnson NL, Zlotnick C, Sullivan TP, Johnson DM. J Interpers Violence. 2022 Jan; 2020 Feb 26. PMID: 32102597.", + "Criminal Orders of Protection for Domestic Violence: Associated Revictimization, Mental Health, and Well-being Among Victims. Sullivan TP, Weiss NH, Woerner J, Wyatt J, Carey C. J Interpers Violence. 2021 Nov; 2019 Oct 28. PMID: 31658852.", + "The Impact of Adverse Childhood Events on the Sexual and Mental Health of Women Experiencing Intimate Partner Violence. Willie TC, Kershaw T, Sullivan TP. J Interpers Violence. 2021 Jun; 2018 Oct 3. PMID: 30280634.", + "Associations between state intimate partner violence-related firearm policies and injuries among women and men who experience intimate partner violence. Willie TC, Kershaw T, Perler R, Caplon A, Katague M, Sullivan TP. Inj Epidemiol. 2021 Feb 22; 2021 Feb 22. PMID: 33612117.", + "Criminal Protection Orders for Women Victims of Domestic Violence: Explicating Predictors of Level of Restrictions Among Orders Issued. Sullivan TP, Weiss NH, Price C, Pugh NE. J Interpers Violence. 2021 Jan; 2017 Oct 12. PMID: 29294951.", + "Social Reactions to IPV Disclosure and PTSD Symptom Severity: Assessing Avoidant Coping as a Mediator. Schackner JN, Weiss NH, Edwards KM, Sullivan TP. J Interpers Violence. 2021 Jan; 2017 Sep 1. PMID: 29294901.", + "Fluctuations in daily PTSD symptoms are related to proximal alcohol use: a micro-longitudinal study of women victims of intimate partner violence. Sullivan TP, Armeli S, Tennen H, Weiss NH, Hansen NB. Am J Drug Alcohol Abuse. 2020; 2019 Jul 16. PMID: 31311330.", + "Post-traumatic stress disorder symptom severity attenuates bi-directional associations between negative affect and avoidant coping: A daily diary study. Weiss NH, Risi MM, Sullivan TP, Armeli S, Tennen H. J Affect Disord. 2019 Dec 1; 2019 Aug 13. PMID: 31442882.", + "If You Can't Say Something Nice: A Latent Profile Analysis of Social Reactions to Intimate Partner Violence Disclosure and Associations With Mental Health Symptoms. Woerner J, Wyatt J, Sullivan TP. Violence Against Women. 2019 Aug; 2018 Dec 4. PMID: 30511587.", + "Emotion dysregulation and posttraumatic stress disorder: a test of the incremental role of difficulties regulating positive emotions. Weiss NH, Nelson RJ, Contractor AA, Sullivan TP. Anxiety Stress Coping. 2019 Jul; 2019 May 17. PMID: 31099270.", + "Social Disconnection as a Pathway to Sexual Risk Behavior Among Victims of Intimate Partner Violence. Woerner J, Sullivan TP. Violence Vict. 2019 Jun 1. PMID: 31171731.", + "An event-level examination of successful condom negotiation strategies among young women. Peasant C, Montanaro EA, Kershaw TS, Parra GR, Weiss NH, Meyer JP, Murphy JG, Ritchwood TD, Sullivan TP. J Health Psychol. 2019 Jun; 2017 Feb 5. PMID: 28810400.", + "The intersection of intimate partner violence and HIV: detection, disclosure, discussion, and implications for treatment adherence. Sullivan TP. Top Antivir Med. 2019 May. PMID: 31136996.", + "Stigmatizing Reactions Versus General Negative Reactions to Partner Violence Disclosure as Predictors of Avoidance Coping and Depression. Overstreet NM, Willie TC, Sullivan TP. J Interpers Violence. 2019 Apr; 2016 Jun 12. PMID: 27296052.", + "Avoidant Coping as a Moderator of the Association Between Childhood Abuse Types and HIV/Sexual Risk Behaviors. Weiss NH, Peasant C, Sullivan TP. Child Maltreat. 2019 Feb; 2018 Aug 19. PMID: 30124064.", + "Daily relationship between positive affect and drinking to cope: the moderating role of difficulties regulating positive emotions. Weiss NH, Risi MM, Bold KW, Sullivan TP, Dixon-Gordon KL. Am J Drug Alcohol Abuse. 2019; 2018 Aug 23. PMID: 30136859.", + "Heterogeneity in emotion regulation difficulties among women victims of domestic violence: A latent profile analysis. Weiss NH, Darosh AG, Contractor AA, Forkus SR, Dixon-Gordon KL, Sullivan TP. J Affect Disord. 2018 Oct 15; 2018 Jul 3. PMID: 30014959.", + "An Examination of the Role of Difficulties Regulating Positive Emotions in Posttraumatic Stress Disorder. Weiss NH, Dixon-Gordon KL, Peasant C, Sullivan TP. J Trauma Stress. 2018 Oct; 2018 Oct 19. PMID: 30338577.", + "Women's Use of Aggression and Their Depressive Symptoms: The Mediating Effect of Aggression-Related Shame and Avoidance Coping Among Women Experiencing Bidirectional Intimate Partner Violence. Overstreet NM, Weiss NH, Swan SC, Sullivan TP. Violence Vict. 2018 Jun. PMID: 30567863.", + "Strategies for coping with individual PTSD symptoms: Experiences of African American victims of intimate partner violence. Sullivan TP, Weiss NH, Price C, Pugh N, Hansen NB. Psychol Trauma. 2018 May; 2017 May 8. PMID: 28481562.", + "Words can hurt: The effects of physical and psychological partner violence on condom negotiation and condom use among young women. Peasant C, Sullivan TP, Ritchwood TD, Parra GR, Weiss NH, Meyer JP, Murphy JG. Women Health. 2018 May-Jun; 2017 Apr 28. PMID: 28402194.", + "Trauma exposure and heavy drinking and drug use among college students: Identifying the roles of negative and positive affect lability in a daily diary study. Weiss NH, Bold KW, Contractor AA, Sullivan TP, Armeli S, Tennen H. Addict Behav. 2018 Apr; 2017 Dec 13. PMID: 29289852.", + "Intimate Partner Violence and HIV-Risk Behaviors: Evaluating Avoidant Coping as a Moderator. Weiss NH, Peasant C, Sullivan TP. AIDS Behav. 2017 Aug. PMID: 27778220.", + "Is Firearm Threat in Intimate Relationships Associated with Posttraumatic Stress Disorder Symptoms Among Women? Sullivan TP, Weiss NH. Violence Gend. 2017 Jun 1. PMID: 28616441.", + "The Researcher-Practitioner Partnership Study (RPPS): Experiences From Criminal Justice System Collaborations Studying Violence Against Women. Sullivan TP, Price C, McPartland T, Hunter BA, Fisher BS. Violence Against Women. 2017 Jun; 2016 Jun 5. PMID: 27271778.", + "A latent profile analysis of intimate partner victimization and aggression and examination of between-class differences in psychopathology symptoms and risky behaviors. Weiss NH, Dixon-Gordon KL, Peasant C, Jaquier V, Johnson C, Sullivan TP. Psychol Trauma. 2017 May; 2016 Oct 13. PMID: 27736140.", + "Racial/ethnic differences moderate associations of coping strategies and posttraumatic stress disorder symptom clusters among women experiencing partner violence: a multigroup path analysis. Weiss NH, Johnson CD, Contractor A, Peasant C, Swan SC, Sullivan TP. Anxiety Stress Coping. 2017 May; 2016 Sep 17. PMID: 27575609.", + "Testing bidirectional associations among emotion regulation strategies and substance use: a daily diary study. Weiss NH, Bold KW, Sullivan TP, Armeli S, Tennen H. Addiction. 2017 Apr; 2017 Jan 2. PMID: 27896905.", + "Beyond the syndemic: condom negotiation and use among women experiencing partner violence. Peasant C, Sullivan TP, Weiss NH, Martinez I, Meyer JP. AIDS Care. 2017 Apr; 2016 Sep 2. PMID: 27590004.", + "Capacity of AIDS service organisations in Connecticut to respond to intimate partner violence. Prust ML, Mellor-Crummey L, Sullivan TP, Lang S, Hansen NB. Health Soc Care Community. 2017 Mar; 2015 Nov 19. PMID: 26584673.", + "Psychological and relational correlates of intimate partner violence profiles among pregnant adolescent couples. Lewis JB, Sullivan TP, Angley M, Callands T, Divney AA, Magriples U, Gordon DM, Kershaw TS. Aggress Behav. 2017 Jan; 2016 May 2. PMID: 27135634.", + "Reflections on a Community Psychology Setting and the Future of the Field. Kaufman JS, Connell CM, Crusto CA, Gordon DM, Sartor CE, Simon P, Strambler MJ, Sullivan TP, Ward NL, Weiss NH, Tebes JK. Am J Community Psychol. 2016 Dec; 2016 Nov 24. PMID: 27883198.", + "Intimate partner aggression-related shame and posttraumatic stress disorder symptoms: The moderating role of substance use problems. Weiss NH, Duke AA, Overstreet NM, Swan SC, Sullivan TP. Aggress Behav. 2016 Sep; 2015 Dec 24. PMID: 26699821.", + "PTSD and Daily Co-Occurrence of Drug and Alcohol Use Among Women Experiencing Intimate Partner Violence. Sullivan TP, Weiss NH, Flanagan JC, Willie TC, Armeli S, Tennen H. J Dual Diagn. 2016. PMID: 26828635.", + "Barriers to HIV Medication Adherence: Examining Distinct Anxiety and Depression Symptoms among Women Living with HIV Who Experienced Childhood Sexual Abuse. Willie TC, Overstreet NM, Sullivan TP, Sikkema KJ, Hansen NB. Behav Med. 2016. PMID: 26010763.", + "Profiles of Intimate Partner Violence Victimization, Substance Misuse, and Depression Among Female Caregivers Involved with Child Protective Services. Hellmuth JC, Sullivan TP, Connell CM. J Fam Violence. 2015 Nov; 2015 Mar 19. PMID: 26617433.", + "Posttraumatic stress disorder symptoms and risky behaviors among trauma-exposed inpatients with substance dependence: The influence of negative and positive urgency. Weiss NH, Tull MT, Sullivan TP, Dixon-Gordon KL, Gratz KL. Drug Alcohol Depend. 2015 Oct 1; 2015 Aug 2. PMID: 26278196.", + "Correlates of smoking status among women experiencing intimate partner violence: Substance use, posttraumatic stress, and coping. Sullivan TP, Flanagan JC, Dudley DN, Holt LJ, Mazure CM, McKee SA. Am J Addict. 2015 Sep; 2015 Aug 6. PMID: 26249027.", + "Drinking to Cope Motivation as a Prospective Predictor of Negative Affect. Armeli S, Sullivan TP, Tennen H. J Stud Alcohol Drugs. 2015 Jul. PMID: 26098033.", + "Explicating the role of emotion dysregulation in risky behaviors: A review and synthesis of the literature with directions for future research and clinical practice. Weiss NH, Sullivan TP, Tull MT. Curr Opin Psychol. 2015 Jun 1. PMID: 25705711.", + "The underlying role of posttraumatic stress disorder symptoms in the association between intimate partner violence and deliberate self-harm among African American women. Weiss NH, Dixon-Gordon KL, Duke AA, Sullivan TP. Compr Psychiatry. 2015 May; 2014 Jun 7. PMID: 25752736.", + "Psychological intimate partner violence and sexual risk behavior: examining the role of distinct posttraumatic stress disorder symptoms in the partner violence-sexual risk link. Overstreet NM, Willie TC, Hellmuth JC, Sullivan TP. Womens Health Issues. 2015 Jan-Feb; 2014 Dec 12. PMID: 25498762.", + "Anxiety and posttraumatic stress symptom pathways to substance use problems among community women experiencing intimate partner violence. Jaquier V, Flanagan JC, Sullivan TP. Anxiety Stress Coping. 2015; 2014 Oct 20. PMID: 25251694.", + "The mediating role of avoidance coping between intimate partner violence (IPV) victimization, mental health, and substance abuse among women experiencing bidirectional IPV. Flanagan JC, Jaquier V, Overstreet N, Swan SC, Sullivan TP. Psychiatry Res. 2014 Dec 15; 2014 Aug 2. PMID: 25174851.", + "Probable posttraumatic stress disorder and women's use of aggression in intimate relationships: the moderating role of alcohol dependence. Weiss NH, Duke AA, Sullivan TP. J Trauma Stress. 2014 Oct. PMID: 25322884.", + "Elucidating posttraumatic stress symptom profiles and their correlates among women experiencing bidirectional intimate partner violence. Hellmuth JC, Jaquier V, Swan SC, Sullivan TP. J Clin Psychol. 2014 Oct; 2014 Apr 19. PMID: 24752965.", + "Episode-specific drinking-to-cope motivation, daily mood, and fatigue-related symptoms among college students. Armeli S, O'Hara RE, Ehrenberg E, Sullivan TP, Tennen H. J Stud Alcohol Drugs. 2014 Sep. PMID: 25208194.", + "Fear of past abusive partner(s) impacts current posttraumatic stress among women experiencing partner violence. Jaquier V, Sullivan TP. Violence Against Women. 2014 Feb; 2014 Mar 2. PMID: 24590514.", + "Evidence for a curvilinear dose-response relationship between avoidance coping and drug use problems among women who experience intimate partner violence. Weiss NH, Duke AA, Sullivan TP. Anxiety Stress Coping. 2014; 2014 Mar 26. PMID: 24592874.", + "Relationship self-efficacy protects against mental health problems among women in bidirectionally aggressive intimate relationships with men. Sullivan TP, McPartland T, Price C, Cruza-Guet MC, Swan SC. J Couns Psychol. 2013 Oct; 2013 Jul 1. PMID: 23815627.", + "Patterns of resource utilization and mental health symptoms among women exposed to multiple types of victimization: a latent class analysis. Young-Wolff KC, Hellmuth J, Jaquier V, Swan SC, Connell C, Sullivan TP. J Interpers Violence. 2013 Oct; 2013 May 17. PMID: 23686622.", + "Posttraumatic stress disorder symptom clusters, alcohol misuse, and women's use of intimate partner violence. Hellmuth JC, Jaquier V, Young-Wolff K, Sullivan TP. J Trauma Stress. 2013 Aug; 2013 Jul 18. PMID: 23868671.", + "Posttraumatic stress and depression symptoms as correlates of deliberate self-harm among community women experiencing intimate partnerviolence. Jaquier V, Hellmuth JC, Sullivan TP. Psychiatry Res. 2013 Mar 30; 2012 Oct 4. PMID: 23040795.", + "Partner violence and health among HIV-infected jail detainees. Meyer JP, Wickersham JA, Fu JJ, Brown SE, Sullivan TP, Springer SA, Altice FL. Int J Prison Health. 2013. PMID: 24376468.", + "Factor structures for aggression and victimization among women who used aggression against male partners. Swan SC, Gambone LJ, Van Horn ML, Snow DL, Sullivan TP. Violence Against Women. 2012 Sep; 2012 Sep 24. PMID: 23012348.", + "Psychological distress and substance use among community-recruited women currently victimized by intimate partners: a latent class analysis and examination of between-class differences. Golder S, Connell CM, Sullivan TP. Violence Against Women. 2012 Aug. PMID: 23008429.", + "Associations between expectancies of alcohol and drug use, severity of partner violence, and posttraumatic stress among women. Peters EN, Khondkaryan E, Sullivan TP. J Interpers Violence. 2012 Jul; 2012 Jan 18. PMID: 22258078.", + "Risk factors for alcohol-related problems among victims of partner violence. Sullivan TP, Ashare RL, Jaquier V, Tennen H. Subst Use Misuse. 2012 May; 2012 Feb 23. PMID: 22360665.", + "IS IT THE EXCEPTION OR THE RULE? DAILY CO-OCCURRENCE OF PHYSICAL, SEXUAL, AND PSYCHOLOGICAL PARTNER VIOLENCE IN A 90-DAY STUDY OF SUBSTANCE-USING, COMMUNITY WOMEN. Sullivan TP, McPartland T, Armeli S, Jaquier V, Tennen H. Psychol Violence. 2012 Apr 1. PMID: 24349863.", + "The role of smoking expectancies in the relationship between PTSD symptoms and smoking behavior among women exposed to intimate partner violence. Ashare RL, Weinberger AH, McKee SA, Sullivan TP. Addict Behav. 2011 Dec; 2011 Jul 29. PMID: 21849230.", + "Applying experience sampling methods to partner violence research: safety and feasibility in a 90-day study of community women. Sullivan TP, Khondkaryan E, Dos Santos NP, Peters EN. Violence Against Women. 2011 Feb. PMID: 21307033.", + "Do differing types of victimization and coping strategies influence the type of social reactions experienced by current victims of intimate partner violence? Sullivan TP, Schroeder JA, Dudley DN, Dixon JM. Violence Against Women. 2010 Jun. PMID: 20445076.", + "Sullivan, T P. (2013). Think outside: Advancing Risk and Protective Factor Research Beyond the Intimate-Partner-Violence Box. Psychology of Violence , 3(2), 121.", + "The Consultation Center 389 Whitney Avenue New Haven, CT 06489", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Sumida Lab", + "lab_url": "https://medicine.yale.edu/lab/sumida/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Suomivuori Lab", + "lab_url": "https://medicine.yale.edu/lab/suomivuori/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/suomivuori/publications/", + "publications": null + }, + { + "lab_name": "Takyar Lab", + "lab_url": "https://medicine.yale.edu/lab/takyar/", + "research_bio": "INFORMATION FOR My research is focused on understanding the genetic and epigenetic basis of a variety of lung disease ranging form asthma to lung cancer. I study gene expression and its regulation at the level of RNA and translation. We routinely use animal models to simulate asthma, lung cancer and metastasis including the transgenic models developed at Yale Pulmonary section over the last 20 years. I have developed methods for isolating various cell types and studying microRNAs in these cells as well as finding genuine targets of the microRNAs by microarray analysis, probing the RISC (RNA Induced Silencing Complex), expression vectors and finally in vivo delivery of microRNAs as naked RNA or in lentiviral vectors and cloning transgenic animal models. Recently I have focused on microRNAs in the lung endothelium and their role in Th2 inflammation, lung angiogenesis and metastasis. I am trying to answer questions such as how and why vascular cells become inflamed in diseases like asthma and how activation of these cells permits the propagation of cancerous cells in the lung. In order to understand these multimodal mechanisms I first use animal models to identify the microRNA alterations that are unique to a specific lung pathology. In the next step, I identify potential candidates for these micoRNAs through various bioinfimartic and biochemical methods and finally I study the role of these microRNAs and their targets by direct delivery to the lungs or transgenic modeling. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Ted Cohen Lab", + "lab_url": "https://medicine.yale.edu/lab/tcohen/", + "research_bio": "INFORMATION FOR We are a group of individuals with diverse academic backgrounds conducting research that contributes to the global effort to control two infectious diseases of public health importance: tuberculosis (TB) and HIV. Our group includes individuals with training in clinical medicine, epidemiology, statistics, applied mathematics and operations research. Our work is both applied and theoretical and we are currently engaged in research projects with partners in Africa, Eastern Europe, and The Americas. We believe that the best solutions to the complex challenges associated with control of TB and HIV are likely to arise through collaborative work between individuals with different training, skills, and perspectives. We welcome opportunities to widen our work through collaboration with others who are engaged in similar endeavors. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/tcohen/publications", + "publications": null + }, + { + "lab_name": "The Burd Lab", + "lab_url": "https://medicine.yale.edu/lab/burd/", + "research_bio": "INFORMATION FOR Copy Link Our research is driven by the desire to understand how the organelles of the endomembrane system - the collection of intracellular, membrane-bounded organelles that compartmentalize the biochemical reactions that fuel life - are assembled and maintained. The endomembrane system is broadly divided into the secretory pathway, which is responsible for the production and distribution of newly synthesized molecules throughout the cell, and the endocytic system, which internalizes components of the extracellular milieu and the plasma membrane. Elucidating the mechanisms that sort molecules to various organelles is of fundamental importance for understanding cell growth, division, multi-cellular development and physiology, and it is also crucial for understanding a broad range of diseases and afflictions - cancer, neurodegenerative disease, infectious disease, and many others. Phosphoinositide and GTPase signaling modules constitute the master regulators of organelle biogenesis. Phosphoinositides (“PIPs”) are generated by phosphorylation of distinct positions on the inositol ring of phosphatidylinositol, an abundant lipid of all cellular membranes. Importantly, the cytoplasmic leaflet of each organelle is enriched in a different PIP, constituting an organelle specific PIP code. Similarly, distinct GTPases of the Rab and Arf families associate with distinct organelles and the transport vesicles that ferry molecules between them. Specific recognition of PIPs and GTPases by sorting and transport factors regulate the composition and identity of each organelle by regulating inter-organelle transport. In our lab we harness yeast genetics/genomics, proteomics, biochemistry, and live cell fluorescence microscopy to elucidate the molecular mechanisms of these sorting and trafficking pathways. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/burd/publications/", + "publications": [ + "Yale School of Medicine /", + "Cell Biology /", + "Publications", + "Open Positions", + "Contact", + "Lab Members", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Publications", + "Open Positions", + "Contact", + "Lab Members", + "", + "", + "", + "", + "", + "", + "Cholesterol depletion activates trafficking-coupled sphingolipid synthesis. Kim Y, Parolek J, Burd CG. bioRxiv. 2025 Feb 16; 2025 Feb 16. PMID: 39990424.", + "Bridge-like lipid transfer protein family member 2 suppresses ciliogenesis. Parolek J, Burd CG. Mol Biol Cell. 2024 May 1; 2024 Mar 27. PMID: 38536441.", + "Cholesterol-dependent homeostatic regulation of very long chain sphingolipid synthesis. Kim Y, Mavodza G, Senkal CE, Burd CG. J Cell Biol. 2023 Dec 4; 2023 Oct 3. PMID: 37787764.", + "Lipid Sorting and Organelle Identity. Kim Y, Burd CG. Cold Spring Harb Perspect Biol. 2023 Oct 3; 2023 Oct 3. PMID: 37487627.", + "Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway. Sokoya T, Parolek J, Foged MM, Danylchuk DI, Bozan M, Sarkar B, Hilderink A, Philippi M, Botto LD, Terhal PA, Mäkitie O, Piehler J, Kim Y, Burd CG, Klymchenko AS, Maeda K, Holthuis JCM. Elife. 2022 Sep 14; 2022 Sep 14. PMID: 36102623.", + "GOPC facilitates the sorting of syndecan-1 in polarized epithelial cells. Ford C, Burd CG. Mol Biol Cell. 2022 Sep 1; 2022 Jul 13. PMID: 35830596.", + "Ca(2+)-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair. Niekamp P, Scharte F, Sokoya T, Vittadello L, Kim Y, Deng Y, Südhoff E, Hilderink A, Imlau M, Clarke CJ, Hensel M, Burd CG, Holthuis JCM. Nat Commun. 2022 Apr 6; 2022 Apr 6. PMID: 35388011.", + "Cargo sorting at the trans-Golgi network at a glance. Ford C, Parchure A, von Blume J, Burd CG. J Cell Sci. 2021 Dec 1; 2021 Dec 6. PMID: 34870705.", + "GRASPing for consensus about the Golgi apparatus. Burd CG. J Cell Biol. 2021 May 3. PMID: 33848329.", + "Conditional targeting of phosphatidylserine decarboxylase to lipid droplets. Kumar S, Chitraju C, Farese RV Jr, Walther TC, Burd CG. Biol Open. 2021 Mar 3; 2021 Mar 3. PMID: 33593792.", + "Retromer forms low order oligomers on supported lipid bilayers. Deatherage CL, Nikolaus J, Karatekin E, Burd CG. J Biol Chem. 2020 Aug 21; 2020 Jul 10. PMID: 32651229.", + "Retrograde trafficking and plasma membrane recycling pathways of the budding yeast Saccharomyces cerevisiae. Ma M, Burd CG. Traffic. 2020 Jan; 2019 Oct 1. PMID: 31471931.", + "Expression, Purification, and Liposome Binding of Budding Yeast SNX-BAR Heterodimers. Ma M, Goyal S, Burd CG, Chi RJ. J Vis Exp. 2019 Dec 6; 2019 Dec 6. PMID: 31868175.", + "Syndecan-1 Mediates Sorting of Soluble Lipoprotein Lipase with Sphingomyelin-Rich Membrane in the Golgi Apparatus. Sundberg EL, Deng Y, Burd CG. Dev Cell. 2019 Nov 4; 2019 Sep 19. PMID: 31543446.", + "Retrograde trafficking and quality control of yeast synaptobrevin, Snc1, are conferred by its transmembrane domain. Ma M, Burd CG. Mol Biol Cell. 2019 Jul 1; 2019 May 8. PMID: 31067149.", + "Monitoring Sphingolipid Trafficking in Cells using Fluorescence Microscopy. Sundberg EL, Deng Y, Burd CG. Curr Protoc Cell Biol. 2019 Mar; 2018 Sep 24. PMID: 30246944.", + "Activity of the SPCA1 Calcium Pump Couples Sphingomyelin Synthesis to Sorting of Secretory Proteins in the Trans-Golgi Network. Deng Y, Pakdel M, Blank B, Sundberg EL, Burd CG, von Blume J. Dev Cell. 2018 Nov 19; 2018 Nov 1. PMID: 30393074.", + "Lipid trafficking by yeast Snx4 family SNX-BAR proteins promotes autophagy and vacuole membrane fusion. Ma M, Kumar S, Purushothaman L, Babst M, Ungermann C, Chi RJ, Burd CG. Mol Biol Cell. 2018 Sep 1; 2018 Jun 27. PMID: 29949447.", + "Lipids and proteins mix it up in Philly. Ma M, Burd CG. Mol Biol Cell. 2018 Mar 15. PMID: 29535177.", + "A CDC25 family protein phosphatase gates cargo recognition by the Vps26 retromer subunit. Cui TZ, Peterson TA, Burd CG. Elife. 2017 Mar 31; 2017 Mar 31. PMID: 28362258.", + "Distinct complexes of yeast Snx4 family SNX-BARs mediate retrograde trafficking of Snc1 and Atg27. Ma M, Burd CG, Chi RJ. Traffic. 2017 Feb; 2017 Jan 16. PMID: 28026081.", + "Sphingomyelin is sorted at the trans Golgi network into a distinct class of secretory vesicle. Deng Y, Rivera-Molina FE, Toomre DK, Burd CG. Proc Natl Acad Sci U S A. 2016 Jun 14; 2016 May 31. PMID: 27247384.", + "Biogenesis of endosome-derived transport carriers. Chi RJ, Harrison MS, Burd CG. Cell Mol Life Sci. 2015 Sep; 2015 May 29. PMID: 26022064.", + "Riding the R Train into the Cell. DiMaio D, Burd CG, Goodner K. PLoS Pathog. 2015 Aug; 2015 Aug 20. PMID: 26291450.", + "Direct binding of retromer to human papillomavirus type 16 minor capsid protein L2 mediates endosome exit during viral infection. Popa A, Zhang W, Harrison MS, Goodner K, Kazakov T, Goodwin EC, Lipovsky A, Burd CG, DiMaio D. PLoS Pathog. 2015 Feb; 2015 Feb 18. PMID: 25693203.", + "Sac1-Vps74 structure reveals a mechanism to terminate phosphoinositide signaling in the Golgi apparatus. Cai Y, Deng Y, Horenkamp F, Reinisch KM, Burd CG. J Cell Biol. 2014 Aug 18; 2014 Aug 11. PMID: 25113029.", + "Fission of SNX-BAR-coated endosomal retrograde transport carriers is promoted by the dynamin-related protein Vps1. Chi RJ, Liu J, West M, Wang J, Odorizzi G, Burd CG. J Cell Biol. 2014 Mar 3; 2014 Feb 24. PMID: 24567361.", + "Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex. Wu X, Chi RJ, Baskin JM, Lucast L, Burd CG, De Camilli P, Reinisch KM. Dev Cell. 2014 Jan 13; 2013 Dec 19. PMID: 24360784.", + "A mechanism for retromer endosomal coat complex assembly with cargo. Harrison MS, Hung CS, Liu TT, Christiano R, Walther TC, Burd CG. Proc Natl Acad Sci U S A. 2014 Jan 7; 2013 Dec 16. PMID: 24344282.", + "Phosphatidylserine flipping enhances membrane curvature and negative charge required for vesicular transport. Xu P, Baldridge RD, Chi RJ, Burd CG, Graham TR. J Cell Biol. 2013 Sep 16; 2013 Sep 9. PMID: 24019533.", + "Rab GTPase regulation of retromer-mediated cargo export during endosome maturation. Liu TT, Gomez TS, Sackey BK, Billadeau DD, Burd CG. Mol Biol Cell. 2012 Jul; 2012 May 16. PMID: 22593205.", + "Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase. Wood CS, Hung CS, Huoh YS, Mousley CJ, Stefan CJ, Bankaitis V, Ferguson KM, Burd CG. Mol Biol Cell. 2012 Jul; 2012 May 2. PMID: 22553352.", + "Physiology and pathology of endosome-to-Golgi retrograde sorting. Burd CG. Traffic. 2011 Aug; 2011 Apr 8. PMID: 21382144.", + "Aggregation of α-synuclein in S. cerevisiae is associated with defects in endosomal trafficking and phospholipid biosynthesis. Soper JH, Kehm V, Burd CG, Bankaitis VA, Lee VM. J Mol Neurosci. 2011 Mar; 2010 Oct 2. PMID: 20890676.", + "Coordination of Golgi functions by phosphatidylinositol 4-kinases. Graham TR, Burd CG. Trends Cell Biol. 2011 Feb; 2010 Nov 4. PMID: 21282087.", + "PtdIns4P recognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking. Wood CS, Schmitz KR, Bessman NJ, Setty TG, Ferguson KM, Burd CG. J Cell Biol. 2009 Dec 28; 2009 Dec 21. PMID: 20026658.", + "Membrane insertion of the FYVE domain is modulated by pH. He J, Vora M, Haney RM, Filonov GS, Musselman CA, Burd CG, Kutateladze AG, Verkhusha VV, Stahelin RV, Kutateladze TG. Proteins. 2009 Sep. PMID: 19296456.", + "Opposing activities of the Snx3-retromer complex and ESCRT proteins mediate regulated cargo sorting at a common endosome. Strochlic TI, Schmiedekamp BC, Lee J, Katzmann DJ, Burd CG. Mol Biol Cell. 2008 Nov; 2008 Sep 3. PMID: 18768754.", + "Golgi localization of glycosyltransferases requires a Vps74p oligomer. Schmitz KR, Liu J, Li S, Setty TG, Wood CS, Burd CG, Ferguson KM. Dev Cell. 2008 Apr. PMID: 18410729.", + "Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae. Soper JH, Roy S, Stieber A, Lee E, Wilson RB, Trojanowski JQ, Burd CG, Lee VM. Mol Biol Cell. 2008 Mar; 2008 Jan 2. PMID: 18172022.", + "Regulation of copper-dependent endocytosis and vacuolar degradation of the yeast copper transporter, Ctr1p, by the Rsp5 ubiquitin ligase. Liu J, Sitaram A, Burd CG. Traffic. 2007 Oct; 2007 Jul 20. PMID: 17645432.", + "Grd19/Snx3p functions as a cargo-specific adapter for retromer-dependent endocytic recycling. Strochlic TI, Setty TG, Sitaram A, Burd CG. J Cell Biol. 2007 Apr 9. PMID: 17420293.", + "Molecular mechanism of membrane docking by the Vam7p PX domain. Lee SA, Kovacs J, Stahelin RV, Cheever ML, Overduin M, Setty TG, Burd CG, Cho W, Kutateladze TG. J Biol Chem. 2006 Dec 1; 2006 Sep 19. PMID: 16984909.", + "Saccharomyces cerevisiae Rab-GDI displacement factor ortholog Yip3p forms distinct complexes with the Ypt1 Rab GTPase and the reticulon Rtn1p. Geng J, Shin ME, Gilbert PM, Collins RN, Burd CG. Eukaryot Cell. 2005 Jul. PMID: 16002643.", + "tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre. Yoshino A, Setty SR, Poynton C, Whiteman EL, Saint-Pol A, Burd CG, Johannes L, Holzbaur EL, Koval M, McCaffery JM, Marks MS. J Cell Sci. 2005 May 15; 2005 May 3. PMID: 15870108.", + "Arf-like GTPases: not so Arf-like after all. Burd CG, Strochlic TI, Setty SR. Trends Cell Biol. 2004 Dec. PMID: 15564045.", + "Role of the cytoskeleton in signaling networks. Forgacs G, Yook SH, Janmey PA, Jeong H, Burd CG. J Cell Sci. 2004 Jun 1; 2004 May 18. PMID: 15150320.", + "Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p. Setty SR, Strochlic TI, Tong AH, Boone C, Burd CG. Nat Cell Biol. 2004 May; 2004 Apr 11. PMID: 15077114.", + "Mechanism of genetic complementation of ammonium transport in yeast by human erythrocyte Rh-associated glycoprotein. Westhoff CM, Siegel DL, Burd CG, Foskett JK. J Biol Chem. 2004 Apr 23; 2004 Feb 13. PMID: 14966114.", + "Global mapping of the yeast genetic interaction network. Tong AH, Lesage G, Bader GD, Ding H, Xu H, Xin X, Young J, Berriz GF, Brost RL, Chang M, Chen Y, Cheng X, Chua G, Friesen H, Goldberg DS, Haynes J, Humphries C, He G, Hussein S, Ke L, Krogan N, Li Z, Levinson JN, Lu H, Ménard P, Munyana C, Parsons AB, Ryan O, Tonikian R, Roberts T, Sdicu AM, Shapiro J, Sheikh B, Suter B, Wong SL, Zhang LV, Zhu H, Burd CG, Munro S, Sander C, Rine J, Greenblatt J, Peter M, Bretscher A, Bell G, Roth FP, Brown GW, Andrews B, Bussey H, Boone C. Science. 2004 Feb 6. PMID: 14764870.", + "The GAP activity of Msb3p and Msb4p for the Rab GTPase Sec4p is required for efficient exocytosis and actin organization. Gao XD, Albert S, Tcheperegine SE, Burd CG, Gallwitz D, Bi E. J Cell Biol. 2003 Aug 18; 2003 Aug 11. PMID: 12913108.", + "Dual prenylation is required for Rab protein localization and function. Calero M, Chen CZ, Zhu W, Winand N, Havas KA, Gilbert PM, Burd CG, Collins RN. Mol Biol Cell. 2003 May; 2003 Feb 6. PMID: 12802060.", + "Golgi recruitment of GRIP domain proteins by Arf-like GTPase 1 is regulated by Arf-like GTPase 3. Setty SR, Shin ME, Yoshino A, Marks MS, Burd CG. Curr Biol. 2003 Mar 4. PMID: 12620188.", + "FYVE domain targets Pib1p ubiquitin ligase to endosome and vacuolar membranes. Shin ME, Ogburn KD, Varban OA, Gilbert PM, Burd CG. J Biol Chem. 2001 Nov 2; 2001 Aug 28. PMID: 11526110.", + "GDP dissociation inhibitor domain II required for Rab GTPase recycling. Gilbert PM, Burd CG. J Biol Chem. 2001 Mar 16; 2000 Dec 14. PMID: 11116150.", + "Determinants of NPC1 expression and action: key promoter regions, posttranscriptional control, and the importance of a \"cysteine-rich\" loop. Watari H, Blanchette-Mackie EJ, Dwyer NK, Watari M, Burd CG, Patel S, Pentchev PG, Strauss JF 3rd. Exp Cell Res. 2000 Aug 25. PMID: 10942596.", + "Visualizing protein dynamics in yeast with green fluorescent protein. Burd CG. Methods Enzymol. 2000. PMID: 11044974.", + "Phosphatidylinositol 3-phosphate recognition by the FYVE domain. Kutateladze TG, Ogburn KD, Watson WT, de Beer T, Emr SD, Burd CG, Overduin M. Mol Cell. 1999 Jun. PMID: 10394369.", + "Molecular dissection of guanine nucleotide dissociation inhibitor function in vivo. Rab-independent binding to membranes and role of Rab recycling factors. Luan P, Balch WE, Emr SD, Burd CG. J Biol Chem. 1999 May 21. PMID: 10329679.", + "Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome. Peterson MR, Burd CG, Emr SD. Curr Biol. 1999 Feb 11. PMID: 10021387.", + "Novel pathways, membrane coats and PI kinase regulation in yeast lysosomal trafficking. Burd CG, Babst M, Emr SD. Semin Cell Dev Biol. 1998 Oct. PMID: 9835640.", + "Acidic di-leucine motif essential for AP-3-dependent sorting and restriction of the functional specificity of the Vam3p vacuolar t-SNARE. Darsow T, Burd CG, Emr SD. J Cell Biol. 1998 Aug 24. PMID: 9722605.", + "Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains. Burd CG, Emr SD. Mol Cell. 1998 Jul. PMID: 9702203.", + "A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast. Burd CG, Peterson M, Cowles CR, Emr SD. Mol Biol Cell. 1997 Jun. PMID: 9201718.", + "Novel Golgi to vacuole delivery pathway in yeast: identification of a sorting determinant and required transport component. Cowles CR, Snyder WB, Burd CG, Emr SD. EMBO J. 1997 May 15. PMID: 9184222.", + "Receptor signalling and the regulation of endocytic membrane transport. Seaman MN, Burd CG, Emr SD. Curr Opin Cell Biol. 1996 Aug. PMID: 8791448.", + "A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins. Burd CG, Mustol PA, Schu PV, Emr SD. Mol Cell Biol. 1996 May. PMID: 8628304.", + "The determinants of RNA-binding specificity of the heterogeneous nuclear ribonucleoprotein C proteins. Görlach M, Burd CG, Dreyfuss G. J Biol Chem. 1994 Sep 16. PMID: 8083209.", + "Conserved structures and diversity of functions of RNA-binding proteins. Burd CG, Dreyfuss G. Science. 1994 Jul 29. PMID: 8036511.", + "The mRNA poly(A)-binding protein: localization, abundance, and RNA-binding specificity. Görlach M, Burd CG, Dreyfuss G. Exp Cell Res. 1994 Apr. PMID: 7908267.", + "RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. Burd CG, Dreyfuss G. EMBO J. 1994 Mar 1. PMID: 7510636.", + "The hnRNP proteins. Görlach M, Burd CG, Portman DS, Dreyfuss G. Mol Biol Rep. 1993 Aug. PMID: 8232298.", + "hnRNP proteins and the biogenesis of mRNA. Dreyfuss G, Matunis MJ, Piñol-Roma S, Burd CG. Annu Rev Biochem. 1993. PMID: 8352591.", + "RNA binding characteristics of a 16 kDa glycine-rich protein from maize. Ludevid MD, Freire MA, Gómez J, Burd CG, Albericio F, Giralt E, Dreyfuss G, Pagès M. Plant J. 1992 Nov. PMID: 1302645.", + "The multiple RNA-binding domains of the mRNA poly(A)-binding protein have different RNA-binding activities. Burd CG, Matunis EL, Dreyfuss G. Mol Cell Biol. 1991 Jul. PMID: 1675426.", + "Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts. Burd CG, Swanson MS, Görlach M, Dreyfuss G. Proc Natl Acad Sci U S A. 1989 Dec. PMID: 2557628.", + "Sterling Hall of Medicine 333 Cedar Street New Haven, CT 06520", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "The Caplan Lab", + "lab_url": "https://medicine.yale.edu/lab/caplan/", + "research_bio": "INFORMATION FOR In the Caplan lab we use a variety of modern techniques to study Cell Biology, Epithelial Cells, the Kidney, Polycystic Kidney Diseases, Physiology, and Ion Pumps. We are always interested in new talent, get in touch with Michael Copy Link", + "publications_page": "https://medicine.yale.edu/lab/caplan/publications", + "publications": null + }, + { + "lab_name": "The Connecticut Study of Epilepsy", + "lab_url": "https://medicine.yale.edu/lab/ctepilepsy/", + "research_bio": "INFORMATION FOR Our study is devoted to the understanding of seizure outcomes as well as the social, educational, employment, and behavioral impact of childhood and adolescent-onset epilepsy on the individual as well as on the family. Up until now, we have been focused on outcomes in the first several years after the child was initially diagnosed with epilepsy. As the members of the Connecticut Study of Epilepsy are quickly reaching later adolescence and adulthood, our goals are to continue these endeavors and provide information relevant to the young adult. In doing so, we hope to provide information that will allow families and physicians to have a broader understanding of this disorder and to be aware of and respond quickly and effectively to the needs of the children and young adults with epilepsy so that they can get on with the rest of their busy and very productive lives. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/ctepilepsy/publications/", + "publications": null + }, + { + "lab_name": "The De Camilli Lab", + "lab_url": "https://medicine.yale.edu/lab/decamilli/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "The Hirsch Lab", + "lab_url": "https://medicine.yale.edu/lab/hirsch/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/hirsch/publications/", + "publications": null + }, + { + "lab_name": "The Kaminski Lab", + "lab_url": "https://medicine.yale.edu/lab/kaminski/", + "research_bio": "INFORMATION FOR Dr Kaminski’s research is currently focused on improving our understanding and treatment of chronic lung diseases such as Idiopathic Pulmonary Fibrosis (IPF), a chronic lung disease characterized by progressive scarring of the lungs, as well as COPD, Sarcoidosis and Asthma. His group applies cutting edge high throughput technologies that measure changes in the sequence, expression or regulation of all the genes in the human genome to identify the mechanisms, improve the diagnosis and develop new therapeutic targets. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/kaminski/publications", + "publications": null + }, + { + "lab_name": "The Kwan Lab", + "lab_url": "https://medicine.yale.edu/lab/jmkwan/", + "research_bio": "INFORMATION FOR Our lab works on translational research to understand the mechanisms behind howclonal hematopoiesis of indeterminate potential (CHIP), a condition of aging and other novel somatic variants may impact cardiovascular healthusing a multi-omics approach, including genomics, cytokine/biomarker profiling, bioengineering with engineered heart tissues and imaging with cardiac MRI. CHIP has been shown to increase the risk of heart disease, heart failure, stroke and death. Yet there are no approved therapies or monitoring guidelines. Our lab has identified novel somatic variants that impact survival in heart failure and identified some novel biomarkers in patients with CHIP. Our goal is to identify potential therapeutic targets to improve cardiovascular outcomes in these patients and provide insights into aging. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/jmkwan/publications/", + "publications": [ + "Yale School of Medicine /", + "Internal Medicine /", + "Cardiovascular Medicine /", + "Research", + "Lab Members", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Lab Members", + "Publications", + "", + "", + "", + "", + "", + "", + "Myocarditis-Associated Cardiogenic Shock: A Nationwide Multicenter Study. El Zarif T, Ambrosini AP, Shahu A, Shen M, Gastanadui MG, Safiriyu I, Guha A, Jacobs M, Ali T, Kwan JM, Hull SC, Baldassarre L, Elliott Miller P. J Am Heart Assoc. 2025 Nov 18; 2025 Nov 11. PMID: 41220123.", + "Clonal Hematopoiesis Risk Score (CHRS) Evaluation as a Prognostic Marker for Death in Cardio-Oncology Cohort. Singh J, Chehayeb RJ, Im Y, Yi I, El Zarif T, Guajardo AF, VanOudenhove J, Halene S, Jha A, Kwan JM. JACC Adv. 2025 Nov 7; 2025 Nov 7. PMID: 41205546.", + "Biochemical characterization of Bifidobacterium bifidum peptidoglycan d,l-endopeptidase BbMep that generates NOD2 ligands. Kwan JMC, Feng S, Ng EWL, Qiao Y. RSC Chem Biol. 2025 Jul 2; 2025 May 30. PMID: 40520142.", + "Gut microbiota-derived GlcNAc-MurNAc is a TLR4 agonist that protects the host gut. Li C, Adamson C, Ng AWR, Liang Y, Hong Z, Loh JT, Ng SK, Kwan JMC, Feng S, Ng EWL, Nair S, Ruedl C, Wong SH, Lam KP, Qiao Y. Nat Commun. 2025 Jul 1; 2025 Jul 1. PMID: 40593577.", + "GLP-1 RA Use and Major Adverse Cardiovascular Events in Patients With Monoclonal Gammopathy of Undetermined Significance. Chi KY, Song J, Desphande S, Lee PL, Soni A, Gonzales-Uribe A, Lessa Y, Morgan AA, Chang Y, Lin YS, Akman Z, Nouri A, Rossi R, Babapour G, Varrias D, Parker T, Baldassarre LA, Jha A, Muchtar E, Hull SC, Kwan JM, Nanna MG. JAMA Netw Open. 2025 Jun 2; 2025 Jun 2. PMID: 40587132.", + "Atrial fibrillation in breast cancer therapy: does tamoxifen confer a lower risk than aromatase inhibitors? Kwaah PA, Mensah SA, Agyemang EA, Kekrebesi JS, Katkov D, Carboo A, Appah G, Rashid HA, Kwan JM. Cardiooncology. 2025 May 31; 2025 May 31. PMID: 40450348.", + "Correction: Evaluating factors impacting early career physician-scientists' decisions to continue research careers in the United States of America. Farhat K, Obradovic A, Siebert A, Tun HN, Noch EK, Kwan JM. BMC Med Educ. 2025 May 9; 2025 May 9. PMID: 40346606.", + "Evaluating factors impacting early career physician-scientists' decisions to continue research careers in the United States of America. Farhat K, Obradovic A, Siebert A, Tun HN, Noch EK, Kwan JM. BMC Med Educ. 2025 Apr 17; 2025 Apr 17. PMID: 40247298.", + "Safety and efficacy of immune checkpoint therapy for the treatment of patients with cardiac metastasis: a multicenter international retrospective study. Nassar AH, Abou Alaiwi S, El Zarif T, Denu R, Macaron W, Abdel-Wahab N, Freeman D, Vasbinder A, Hayeck S, Anderson E, Goodman RS, Johnson DB, Grynberg S, Shapira R, Kwan JM, Woodford R, Long GV, Haykal T, Dent S, Kojima Y, Yonemor K, Tandon A, Trevino A, Akhter N, Yang EH, Hui G, Drakaki A, El-Am E, Kozaily E, Al-Hader A, Bou Farhat E, Babu P, Mittra A, Li M, Jones N, Baena J, Juarez Herrera M, Foderaro S, Nana FA, Kim C, Sackstein P, Parikh K, Desai AP, Smith C, Cortellini A, Pinato DJ, Korolewicz J, Lopetegui-Lia N, Funchain P, Choudhary A, Asnani A, Navani V, Meyers D, Stukalin I, Ocejo Gallegos JA, Trent J, Nusrat S, Malvar C, McKay RR, Neilan TG, Choueiri TK, Naqash AR. J Immunother Cancer. 2025 Mar 3; 2025 Mar 3. PMID: 40032601.", + "Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors. Kwan JM, Shen M, Akhlaghi N, Hu JR, Mora R, Cross JL, Jiang M, Mankbadi M, Wang P, Zaman S, Lee S, Im Y, Feher A, Liu YH, Ma SS, Tao W, Wei W, Baldassarre LA. PLoS One. 2024; 2024 Dec 2. PMID: 39621799.", + "Diastolic dysfunction evaluation by cardiovascular magnetic resonance derived E, a, e': Comparison to echocardiography. Lamy J, Xiang J, Shah N, Kwan JM, Kim Y, Upadhyaya K, Reinhardt SW, Meadows J, McNamara RL, Baldassarre LA, Peters DC. Physiol Rep. 2024 Dec. PMID: 39604208.", + "Clonal hematopoiesis of indeterminate potential is associated with increased risk of immune checkpoint inhibitor myocarditis in a prospective study of a cardio-oncology cohort. Jaber Chehayeb R, Singh J, Matute-Martinez C, Chen NW, Guajardo AF, Lin D, Jayakrishnan R, Christofides A, Leveille E, Im Y, Biancon G, VanOudenhove J, Ibrahim E, Ardasheva A, Jha A, Hwa J, Halene S, Kwan JM. Cardiooncology. 2024 Nov 26; 2024 Nov 26. PMID: 39587635.", + "Clonal Hematopoiesis Is Associated With Cardiomyopathy During Solid Tumor Therapy. Leveille E, Jaber Cheheyeb R, Matute-Martinez C, Chen NW, Jayakrishnan R, Christofides A, Lin D, Im Y, Biancon G, VanOudenhove J, Halene S, Kwan JM. JACC CardioOncol. 2024 Aug; 2024 Jul 2. PMID: 39239339.", + "Somatic Variants Acquired Later in Life Associated with Thoracic Aortic Aneurysms: JAK2 V617F. Waldron C, Zafar MA, Ma D, Zhang H, Dykas D, Ziganshin BA, Popa A, Jha A, Kwan JM, Elefteriades JA. Genes (Basel). 2024 Jul 5; 2024 Jul 5. PMID: 39062663.", + "Impact of COVID-19 pandemic on physician-scientist trainees to faculty one year into the pandemic. Obradovic A, Toubat O, Chen NW, Siebert A, Jansen C, Christophers B, Leveille E, Noch E, Kwan JM. BMC Med Educ. 2024 May 28; 2024 May 28. PMID: 38807106.", + "Clinical Interpretation of Serum Troponin in the Era of High-Sensitivity Testing. Maayah M, Grubman S, Allen S, Ye Z, Park DY, Vemmou E, Gokhan I, Sun WW, Possick S, Kwan JM, Gandhi PU, Hu JR. Diagnostics (Basel). 2024 Feb 26; 2024 Feb 26. PMID: 38472975.", + "Clinical Biochemistry of Serum Troponin. Gokhan I, Dong W, Grubman D, Mezue K, Yang D, Wang Y, Gandhi PU, Kwan JM, Hu JR. Diagnostics (Basel). 2024 Feb 9; 2024 Feb 9. PMID: 38396417.", + "Clinical Outcomes Among Immunotherapy-Treated Patients With Primary Cardiac Soft Tissue Sarcomas: A Multicenter Retrospective Study. Nassar AH, El-Am E, Denu R, Abou Alaiwi S, El Zarif T, Macaron W, Abdel-Wahab N, Desai A, Smith C, Parikh K, Abbasi M, Bou Farhat E, Williams JM, Collins JD, Al-Hader A, McKay RR, Malvar C, Sabra M, Zhong C, El Alam R, Chehab O, Lima J, Phan M, Dalla Pria HF, Trevino A, Neilan TG, Kwan JM, Ravi V, Deshpande H, Demetri G, Choueiri TK, Naqash AR. JACC CardioOncol. 2024 Feb; 2024 Jan 16. PMID: 38510282.", + "In silico MS/MS prediction for peptidoglycan profiling uncovers novel anti-inflammatory peptidoglycan fragments of the gut microbiota. Kwan JMC, Liang Y, Ng EWL, Sviriaeva E, Li C, Zhao Y, Zhang XL, Liu XW, Wong SH, Qiao Y. Chem Sci. 2024 Jan 31; 2024 Jan 5. PMID: 38303944.", + "Impact of COVID-19 Pandemic on Physician-Scientist Trainees to Faculty One Year into the Pandemic. Obradovic A, Toubat O, Chen NW, Siebert A, Jansen C, Christophers B, Leveille E, Noch E, Kwan JM. Res Sq. 2023 Nov 8; 2023 Nov 8. PMID: 37986886.", + "Microfluidic Immuno-Serolomic Assay Reveals Systems Level Association with COVID-19 Pathology and Vaccine Protection. Kim D, Biancon G, Bai Z, VanOudenhove J, Liu Y, Kothari S, Gowda L, Kwan JM, Buitrago-Pocasangre NC, Lele N, Asashima H, Racke MK, Wilson JE, Givens TS, Tomayko MM, Schulz WL, Longbrake EE, Hafler DA, Halene S, Fan R. Small Methods. 2023 Oct; 2023 Jun 13. PMID: 37312418.", + "Improving Support for Physician Scientists-Mind the (Funding) Gap. Kwan JM, Gross CP. JAMA Netw Open. 2023 Sep 5; 2023 Sep 5. PMID: 37725379.", + "Arrhythmic and thromboembolic outcomes in adults with coarctation of the aorta. Shadarevian J, Zhu K, Kwan JM, Wan D, Grewal J, Barlow A, Sathananthan G, Chakrabarti S. Int J Cardiol. 2023 Aug 15; 2023 May 29. PMID: 37257511.", + "Quantitative cardiovascular magnetic resonance findings and clinical risk factors predict cardiovascular outcomes in breast cancer patients. Kwan JM, Arbune A, Henry ML, Hu R, Wei W, Nguyen V, Lee S, Lopez-Mattei J, Guha A, Huber S, Bader AS, Meadows J, Sinusas A, Mojibian H, Peters D, Lustberg M, Hull S, Baldassarre LA. PLoS One. 2023; 2023 May 30. PMID: 37252927.", + "Myocardial Injury on CMR in Patients With COVID-19 and Suspected Cardiac Involvement. Vidula MK, Rajewska-Tabor J, Cao JJ, Kang Y, Craft J, Mei W, Chandrasekaran PS, Clark DE, Poenar AM, Gorecka M, Malahfji M, Cowan E, Kwan JM, Reinhardt SW, Al-Tabatabaee S, Doeblin P, Villa ADM, Karagodin I, Alvi N, Christia P, Spetko N, Cassar MP, Park C, Nambiar L, Turgut A, Azad MR, Lambers M, Wong TC, Salerno M, Kim J, Elliott M, Raman B, Neubauer S, Tsao CW, LaRocca G, Patel AR, Chiribiri A, Kelle S, Baldassarre LA, Shah DJ, Hughes SG, Tong MS, Pyda M, Simonetti OP, Plein S, Han Y. JACC Cardiovasc Imaging. 2023 May; 2023 Jan 11. PMID: 36752429.", + "Mechanistic Insights into the Activities of Major Families of Enzymes in Bacterial Peptidoglycan Assembly and Breakdown. Kwan JMC, Qiao Y. Chembiochem. 2023 Apr 3; 2023 Mar 8. PMID: 36715567.", + "Escherichia coli has robust regulatory mechanisms against elevated peptidoglycan cleavage by lytic transglycosylases. Liang Y, Zhao Y, Kwan JMC, Wang Y, Qiao Y. J Biol Chem. 2023 Apr; 2023 Mar 16. PMID: 36931392.", + "LipidA-IDER to Explore the Global Lipid A Repertoire of Drug-Resistant Gram-Negative Bacteria. Guan XL, Loh JY, Lizwan M, Chan SCM, Kwan JMC, Lim TP, Koh TH, Hsu LY, Lee BTK. Anal Chem. 2023 Jan 17; 2023 Jan 4. PMID: 36599414.", + "Short-Term Outcomes After Myopericarditis Related to COVID-19 Vaccination. Pareek M, Steele J, Asnes J, Baldassarre LA, Casale LR, Desai NR, Elder RW, Faherty E, Ferguson I, Fishman RF, Ghazizadeh Z, Glick LR, Hall EK, Khera R, Kokkinidis DG, Kwan JM, O'Marr J, Schussheim A, Tuohy E, Wang Y, Spatz ES, Jacoby D, Miller EJ. JACC Cardiovasc Imaging. 2022 Nov; 2022 May 11. PMID: 36357140.", + "The Impact of COVID-19 on Physician-Scientist Trainees and Faculty in the United States: A National Survey. Kwan JM, Noch E, Qiu Y, Toubat O, Christophers B, Azzopardi S, Gilmer G, Wiedmeier JE, Daye D. Acad Med. 2022 Oct 1; 2022 Sep 23. PMID: 35921163.", + "Microfluidic immuno-serology assay revealed a limited diversity of protection against COVID-19 in patients with altered immunity. Kim D, Biancon G, Bai Z, VanOudenhove J, Liu Y, Kothari S, Gowda L, Kwan JM, Buitrago-Pocasangre NC, Lele N, Asashima H, Racke MK, Wilson JE, Givens TS, Tomayko MM, Schulz WL, Longbrake EE, Hafler DA, Halene S, Fan R. bioRxiv. 2022 Sep 2; 2022 Sep 2. PMID: 36093346.", + "Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 2: Inflammation, Fibrosis, Thrombosis, Calcification, and Amyloidosis Imaging. Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. J Nucl Med. 2022 Jul. PMID: 35772956.", + "Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging. Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. J Nucl Med. 2022 May. PMID: 35487563.", + "Characteristics, barriers, and career intentions of a national cohort of LGBTQ+ MD/PhD and DO/PhD trainees. Marr MC, Heffron AS, Kwan JM. BMC Med Educ. 2022 Apr 21; 2022 Apr 21. PMID: 35449040.", + "Multimodality Advanced Cardiovascular and Molecular Imaging for Early Detection and Monitoring of Cancer Therapy-Associated Cardiotoxicity and the Role of Artificial Intelligence and Big Data. Kwan JM, Oikonomou EK, Henry ML, Sinusas AJ. Front Cardiovasc Med. 2022; 2022 Mar 15. PMID: 35369354.", + "Gender disparities among medical students choosing to pursue careers in medical research: a secondary cross-sectional cohort analysis. Snyder A, Xiang D, Smith A, Esswein S, Toubat O, Di Capua J, Kwan JM, Daye D. BMC Med Educ. 2021 Nov 25; 2021 Nov 25. PMID: 34823508.", + "The bacterial tyrosine kinase system CpsBCD governs the length of capsule polymers. Nakamoto R, Kwan JMC, Chin JFL, Ong HT, Flores-Kim J, Midonet C, VanNieuwenhze MS, Guan XL, Sham LT. Proc Natl Acad Sci U S A. 2021 Nov 9. PMID: 34732571.", + "Adverse cardiovascular events in patients treated with mogamulizumab. Kwan JM, Henry ML, Cook K, Higgins A, Cuomo J, Foss F, Baldassarre LA. Am Heart J Plus. 2021 Sep; 2021 Oct 6. PMID: 38559371.", + "The Role and Impact of Social Media in Cardio-oncology During the COVID-19 Pandemic. Kwan JM, Henry ML, Christophers B, Tamirisa K, Thamman R, Sadler D, Aggarwal NR, Cheng R, Parwani P, Dent S, Ismail-Khan R, Fradley MG, Brown SA. Curr Oncol Rep. 2021 Jul 14; 2021 Jul 14. PMID: 34259950.", + "Mogamulizumab-Associated Acute Myocarditis in a Patient With T-Cell Lymphoma. Kwan JM, Odanovic N, Arbune A, Higgins A, Henry M, Greif D, Foss F, Baldassarre LA. JACC Case Rep. 2021 Jul 7; 2021 Jun 2. PMID: 34317676.", + "A new classification of cardio-oncology syndromes. de Boer RA, Aboumsallem JP, Bracun V, Leedy D, Cheng R, Patel S, Rayan D, Zaharova S, Rymer J, Kwan JM, Levenson J, Ronco C, Thavendiranathan P, Brown SA. Cardiooncology. 2021 Jun 21; 2021 Jun 21. PMID: 34154667.", + "Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation. Gu SX, Tyagi T, Jain K, Gu VW, Lee SH, Hwa JM, Kwan JM, Krause DS, Lee AI, Halene S, Martin KA, Chun HJ, Hwa J. Nat Rev Cardiol. 2021 Mar; 2020 Nov 19. PMID: 33214651.", + "Left ventricular myocardial strain and tissue characterization by cardiac magnetic resonance imaging in immune checkpoint inhibitor associated cardiotoxicity. Higgins AY, Arbune A, Soufer A, Ragheb E, Kwan JM, Lamy J, Henry M, Cuomo JR, Charifa A, Gallegos C, Hull S, Coviello JS, Bader AS, Peters DC, Huber S, Mojibian HR, Sinusas AJ, Kluger H, Baldassarre LA. PLoS One. 2021; 2021 Feb 19. PMID: 33606757.", + "Circulating markers of angiogenesis and endotheliopathy in COVID-19. Pine AB, Meizlish ML, Goshua G, Chang CH, Zhang H, Bishai J, Bahel P, Patel A, Gbyli R, Kwan JM, Won CH, Price C, Dela Cruz CS, Halene S, van Dijk D, Hwa J, Lee AI, Chun HJ. Pulm Circ. 2020 Oct-Dec; 2020 Nov 25. PMID: 33282193.", + "Factors associated with underrepresented minority physician scientist trainee career choices. Siebert AL, Chou S, Toubat O, Adami AJ, Kim H, Daye D, Kwan JM. BMC Med Educ. 2020 Nov 11; 2020 Nov 11. PMID: 33176758.", + "Photoinduced site-selective alkenylation of alkanes and aldehydes with aryl alkenes. Cao H, Kuang Y, Shi X, Wong KL, Tan BB, Kwan JMC, Liu X, Wu J. Nat Commun. 2020 Apr 23; 2020 Apr 23. PMID: 32327665.", + "A nationwide assessment of perceptions of research-intense academic careers among predoctoral MD and MD-PhD trainees. Kwan JM, Toubat O, Harrison AM, Riddle M, Wu B, Kim H, Basta DW, Adami AJ, Daye D. J Clin Transl Sci. 2020 Mar 4; 2020 Mar 4. PMID: 33244411.", + "Functional ageing in fibrotic interstitial lung disease: the impact of frailty on adverse health outcomes. Guler SA, Kwan JM, Leung JM, Khalil N, Wilcox PG, Ryerson CJ. Eur Respir J. 2020 Jan; 2020 Jan 23. PMID: 31537699.", + "Hepatotoxicity and Recurrent NSTEMI While on Pembrolizumab for Metastatic Giant Cell Bone Tumor. Kwan JM, Cheng R, Feldman LE. Am J Med Sci. 2019 Apr; 2018 Nov 29. PMID: 30638772.", + "Maps & Directions", + "Calendar", + "Contact Us", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "The Liu Lab", + "lab_url": "https://medicine.yale.edu/lab/jun-liu/", + "research_bio": "INFORMATION FOR The Liu laboratory is dedicated to developing a high-throughputcryo-electron tomography (cryo-ET)pipeline for high-resolution structure determination of molecular machines in cells. Our state-of-the-art imaging system has been utilized to gain molecular insights into fundamental biochemical processes: bacterial motility, chemotactic signaling, protein secretion, and DNA translocation. Copy Link 00:00:37 Molecular mechanism for rotational switching of the bacterial flagellar motor", + "publications_page": "https://medicine.yale.edu/lab/jun-liu/publications/", + "publications": null + }, + { + "lab_name": "The Mi Lab", + "lab_url": "https://medicine.yale.edu/lab/mi/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "The PACE (Pediatric Advanced Cancer Experience) Laboratory", + "lab_url": "https://medicine.yale.edu/lab/pace/", + "research_bio": "INFORMATION FOR The PACE lab at Yale School of Medicine focuses on studying ways to optimize palliative and supportive care for children with advanced cancer. We use different research approaches, including qualitative and quantitative methods, to better understand the quality of care that children with cancer receive. We also believe that it is crucial to collaborate with patients, families, and interdisciplinary healthcare professionals in our work. Our lab celebrates inclusive excellence. We recognize that our team only stands to gain from including members with different backgrounds, ways of life, experiences, and opinions. We hold ourselves accountable for treating each other fairly and equally to create the best environment possible to succeed in our goals as researchers and individuals. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/pace/pubs", + "publications": null + }, + { + "lab_name": "The Sigworth Laboratory", + "lab_url": "https://medicine.yale.edu/lab/sigworth/", + "research_bio": "INFORMATION FOR Work in our laboratory centers on the function and structure of ion channel proteins. Ion channels are molecular transducers that switch on and off electrical currents that are carried by ions across biological membranes. Depending on the ion channel type, the switching action is controlled by voltage, mechanical forces, or the binding of particular small molecules (ligands). We call these channels voltage-gated, mechanosensitive and ligand-gated channels, respectively. Voltage-gated and ligand-gated ion channels are well known for their role in electrical activity of nerve cells, but ion channels are found in many other places too. Ion channel defects are responsible for disorders like Cystic Fibrosis, cardiac arrhythmias, and some kinds of hypertension and kidney disease. Patch-Clamp Advances in biology come from advances in instrumentation and techniques. We are working in two areas of technology development. We are developing fully integrated patch-clamp amplifier systems that would facilitate the fabrication of automatic, high-throughput recording systems that can patch 384 or more cells in parallel. To simplify the structure determination of membrane proteins (such as ion channels) we are pursuing technical advances in electron microscopy of frozen single-molecule specimens (single-particle cryo-EM) and the mathematical reconstruction of 3D structures from electron microscope images.", + "publications_page": "https://medicine.yale.edu/lab/sigworth/publications/", + "publications": null + }, + { + "lab_name": "Tian Xu Laboratory", + "lab_url": "https://medicine.yale.edu/lab/xu/", + "research_bio": "INFORMATION FOR Our laboratory is interested in utilizing model organisms to understand cancer biology and developmental mechanisms. In particular, we are developing and using new genetic approaches to identify genes that are involved in tumor growth and metastasis, and are exploring the developmental and biochemical functions of these genes. To learn more about our research activities, please see ourResearchsection. Copy Link Tian Xu is an Adjunct Professor in Genetics at Yale School of Medicine. He is currently Vice President atWestlake University. Additionally, he serves as an Adjunct Professor and Director of theInstitute of Developmental Biology and Molecular Medicine at Fudan University, Shanghai. Copy Link Associate Research Scientist in Genetics Email:da-ming.li@yale.edu Phone: 203-737-4452 Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Tinaz Lab", + "lab_url": "https://medicine.yale.edu/lab/tinaz/", + "research_bio": "INFORMATION FOR Copy Link We investigate the brain changes in movement disorders - especially Parkinson's disease - using imaging tools such as magnetic resonance imaging, dopamine transporter scans, and positron emission tomography. We are particularly interested in investigating the brain basis of motor, behavioral, and cognitive symptoms, as well as the plasticity changes in response to mental training and physical exercise in Parkinson's disease. Copy Link Our affiliated centers and institutions include: Copy Link", + "publications_page": "https://medicine.yale.edu/lab/tinaz/publications", + "publications": null + }, + { + "lab_name": "Tomayko Lab", + "lab_url": "https://medicine.yale.edu/lab/tomayko/", + "research_bio": "INFORMATION FOR Copy Link The ability to develop immunological memory to infectious diseases is critical for health and survival. Our laboratory studies how this long-term immunity is established and maintained in order to better understand natural immunity, improve vaccine design and develop more effective therapies for autoimmune disease. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/tomayko/publications/", + "publications": null + }, + { + "lab_name": "Townsend Lab", + "lab_url": "https://medicine.yale.edu/lab/townsend/", + "research_bio": "INFORMATION FOR Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/townsend/sand/bagelsoftwarepapers", + "publications": null + }, + { + "lab_name": "Translational Research in Malaria", + "lab_url": "https://medicine.yale.edu/lab/parikh/", + "research_bio": "INFORMATION FOR Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/parikh/publications/", + "publications": null + }, + { + "lab_name": "Trauma and Mental Health (TMH) Lab", + "lab_url": "https://medicine.yale.edu/lab/lowe/", + "research_bio": "INFORMATION FOR Sarah Lowe, Ph.D., is a clinical psychologist and Assistant Professor in the Department of Social and Behavioral Sciences at Yale School of Public Health. Her research focuses on the long-term mental health consequences of a range of potentially traumatic events, from hurricanes to pandemics. While doing her clinical training with trauma survivors at a community health care center in Boston, Lowe's patients were dealing with more immediate life stressors, like not having a place to live. \"That showed me that you can't understand mental health without paying attention to the context and the social and economic stressors that trauma survivors face,\" she says. Lowe explains that within public health \"we're able to look at those things simultaneously. So both the symptoms and treating symptoms but also thinking about systems and policies that both put people at risk for trauma, but then make their traumatic experiences even more negatively impactful.\" As a disaster mental health researcher, Lowe immediately knew the COVID-19 pandemic was going to be a mental health crisis. She's collaborated with students and other faculty on work related to the pandemic and mental health, particularly the mental health burden of health care workers on the frontlines. \"I can say in this pandemic, Yale was able to provide support to me and to my colleagues to do really cutting-edge research. Just observing my colleagues  on the forefront of the response to the pandemic doing things like modeling transmission, understanding the genetics of the virus, that's been really really inspiring to see.\" Copy Link Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Tsai Lab", + "lab_url": "https://medicine.yale.edu/lab/tsai/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/tsai/publications/", + "publications": [ + "Yale School of Medicine /", + "Psychiatry /", + "Research", + "Contact", + "Lab Members", + "Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Lab Members", + "Publications", + "News", + "Contact", + "", + "", + "", + "", + "", + "", + "Psychiatric disorders among older U.S. women by socioeconomic and veteran status. Beydoun HA, Beydoun MA, Hale L, Wallace RB, Jung SY, Saquib N, Szymkowiak D, Derefinko K, Zonderman AB, Brunner R, Tsai J. J Affect Disord. 2025 Dec 15; 2025 Aug 7. PMID: 40782919.", + "Development of a Surveillance System to Identify Incidence of Evictions Among Patients in Veterans Affairs Medical Centers Across the United States. Tsai J, Rajan SS, Yao Z, Reisman J, Liu W, Yu H. J Community Health. 2025 Dec; 2025 Jun 9. PMID: 40489043.", + "A Mixed-methods Study to Identify Behaviors of High-performing Contact Tracers. Tsai J, Grace A, Johnson P. J Public Health Manag Pract. 2025 Nov-Dec 01; 2025 Oct 21. PMID: 40997255.", + "SARS-CoV-2 Positivity, Indicators of COVID-19 Severity, COVID-19 Hospitalization, and Diabetes Risk in the Women's Health Initiative. Beydoun HA, Manson JE, Beydoun MA, Tsai J, Shadyab AH, Jung SY, Liu S, Allison M, Ikramuddin F, Mouton CP, Nuño T, Zonderman AB, Tinker LF. J Womens Health (Larchmt). 2025 Nov; 2025 Aug 20. PMID: 40833820.", + "The role of socioeconomic and structural vulnerability risk factors in employment outcomes for individuals with Schizophrenia and other psychotic disorders. Zencir T, Celik Zencir A, Tekinarslan G, Koc M, Tsai J, Lee B, Umucu E. Psychiatry Res. 2025 Oct 20; 2025 Oct 20. PMID: 41135203.", + "A Federal Demonstration Project of Money Management Services for Veterans at Risk of Homelessness. Tsai J, Matsuura T, Harper A, Rosenheck R. Psychiatr Serv. 2025 Oct 1; 2025 Sep 4. PMID: 40904050.", + "Family incarceration and barriers to mental health care among low-income US veterans. Testa A, Mijares L, Tsai J. Ann Epidemiol. 2025 Oct; 2025 Aug 11. PMID: 40803516.", + "Traumatic brain injury and VA service use among Native Hawaiian and Pacific Islander Veterans experiencing homelessness. Holliday R, Monteith L, Liu S, Lum S, Sia M, Iwamasa G, Aase D, Smith A, Deka R, Jordan S, Kindler C, Tsai J, Brenner LA. Front Public Health. 2025; 2025 Sep 19. PMID: 41048262.", + "Retrospective Study of Homelessness among Transitioning Service Members Within Two Years after Military Service. Tsai J, Szymkowiak D. Adm Policy Ment Health. 2025 Sep 17; 2025 Sep 17. PMID: 40958076.", + "Screening for Hypertension and Diabetes in Laundromats in the Largest Hispanic-Majority City in the U.S. McCann NA, Schick V, Tsai J. Am J Health Promot. 2025 Sep 13; 2025 Sep 13. PMID: 40944951.", + "Problematic Pornography Use and Clinical and Psychosocial Correlates Among Low-Income U.S. Veterans: an Exploratory Study. Stefanovics EA, Potenza MN, Tsai J. Psychiatr Q. 2025 Sep 4; 2025 Sep 4. PMID: 40906215.", + "A Descriptive Study of Perceived Physical Safety Among Service Providers in the Department of Veterans Affairs Homeless Programs. Edwards-Stewart A, Anderson AJ, Tsai J. J Evid Based Soc Work (2019). 2025 Aug 14; 2025 Aug 14. PMID: 40810809.", + "Attitudes and Knowledge about Electroconvulsive therapy among Individuals with Schizophrenia and their Relatives: the Role of Direct Experience. Yıldırım YE, Çetinay Aydın P, Tsai J. Community Ment Health J. 2025 Jul 29; 2025 Jul 29. PMID: 40728796.", + "Is Gaining Housing Associated With Higher Rates of Cancer Screening Among US Veterans Experiencing Homelessness? Decker H, Graham L, Titan A, Kanzaria H, Hawn M, Wick E, Tsai J, Kushel M. Ann Fam Med. 2025 Jul 28; 2025 Jul 28. PMID: 40721329.", + "Families served during the first decade of the Supportive Services for Veteran Families program: a descriptive analysis. Wilkinson R, Long KNG, Cowden RG, Koh HK, Byrne TH, Melendez AN, Tsai J. Front Public Health. 2025; 2025 Jul 24. PMID: 40777646.", + "SynthEHR-Eviction: Enhancing Eviction SDoH Detection with LLM-Augmented Synthetic EHR Data. Yao Z, Zhao Y, Mitra A, Levy DA, Druhl E, Tsai J, Yu H. medRxiv. 2025 Jul 14; 2025 Jul 14. PMID: 40791675.", + "Protocol for the Houston Hospital-based violence intervention program. Testa A, Bluth E, Monroe L, Harris K, Abbott SB, Aitken ME, Fox EE, Heckler B, Kao LS, Li R, Michael SM, McPherson HM, Nieves M, Owen CP, Rix K, Jalaparthi HS, Schick V, Sharma SV, Stratemann C, Thompson AMV, Tsai J, Yang Z, McKay S. PLoS One. 2025; 2025 Jul 2. PMID: 40601592.", + "Meta-analysis of Critical Time Intervention on Clinical and Psychosocial Outcomes. Tsai J, Schrader SW, Beydoun HA. J Nerv Ment Dis. 2025 Jul 1; 2025 Jul 7. PMID: 40622297.", + "Correction: Brief Scoping Review of Community Hubs for the Care of Pregnant Mothers and Their Infants. Tsai J, Camacho A, Ganduglia-Cazaban C. Matern Child Health J. 2025 Jul. PMID: 40332637.", + "Haven for Hope: A Transformational Campus Model to Address Homelessness. Tsai J, Gonzalez KD, Orsinger R, Jefferies K. Community Ment Health J. 2025 Jul; 2024 Dec 6. PMID: 39641884.", + "Sex-specific associations between homelessness and cerebrovascular disease among aging US veterans in the Veterans Affairs healthcare system. Beydoun HA, Beydoun MA, Khatana SAM, Nixdorff N, Mishra NK, Tsai J. Geroscience. 2025 Jun 30; 2025 Jun 30. PMID: 40588576.", + "Role of homelessness and incarceration in time-to-decision on veterans affairs disability benefits for a mental health condition. Beydoun HA, Gianoli M, Meisler A, Tsai J. Psychol Serv. 2025 Jun 30; 2025 Jun 30. PMID: 40587324.", + "Housing status, mental health, and help-seeking among American Indian and Alaska Native Veterans in the Midwest. Umucu E, Lee B, Chang C, Tsai J. Front Public Health. 2025; 2025 Jun 18. PMID: 40606114.", + "Comparing major comorbidity indices as predictors of all-cause mortality in the Veterans Affairs health care system. Beydoun HA, Szymkowiak D, Beydoun MA, Nixdorff N, Brunner R, Tsai J. J Clin Epidemiol. 2025 Jun; 2025 Apr 2. PMID: 40185292.", + "Rates of anxiety disorders, mood disorders, and substance use disorders in federally qualified health centers, 2019-2022. Tsai J, Witte L, Schick V. Psychiatry Res. 2025 Jun; 2025 Mar 23. PMID: 40147089.", + "Cardiovascular disease, bone fracture, and all-cause mortality risks among postmenopausal women by arthritis and veteran status: A multistate Markov transition analysis. Beydoun HA, Beydoun MA, Weiss J, Brunner R, Mishra NK, Ding M, Wactawski-Wende J, Gradidge PJ, Liu S, Tsai J. Geroscience. 2025 Jun; 2025 Jan 29. PMID: 39875753.", + "Protocol for the Houston Hospital-Based Violence Intervention Program. Testa A, Bluth E, Monroe L, Harris K, Abbott SB, Aitken ME, Fox EE, Heckler B, Kao LS, Li R, Michael SM, McPherson HM, Nieves M, Owen CP, Rix K, Schick V, Sharma SV, Stratemann C, Thompson AMV, Tsai J, Yang Z, McKay S. medRxiv. 2025 May 19; 2025 May 19. PMID: 40661309.", + "Use, Benefits, and Barriers to Financial and Credit Counseling Among Veterans According to Financial Counselors and Other Subject Matter Experts. Kinney RL, Hooshyar D, Tsai J. Mil Med. 2025 Apr 23. PMID: 39954081.", + "Mixed-Methods Study of Use and Attitudes About Psychedelics for Therapeutic Purposes Among Low-Income U.S. Veterans Nationally. Tsai J, Witte L, Fate T. J Psychoactive Drugs. 2025 Mar 24; 2025 Mar 24. PMID: 40126357.", + "Brief Scoping Review of Pathways Community Hubs for the Care of Pregnant Mothers and Their Infants. Tsai J, Camacho A, Ganduglia-Cazaban C. Matern Child Health J. 2025 Mar; 2025 Jan 28. PMID: 39873937.", + "Identifying diagnosed major chronic diseases associated with recent housing instability among aging adults: data from the 'All of Us' research program. Beydoun HA, Mayno Vieytes CA, Beydoun MA, Lampros A, Tsai J. J Public Health (Oxf). 2025 Feb 28. PMID: 39586798.", + "Prevalence of mental health conditions, substance use disorders, suicidal ideation and attempts, and experiences of homelessness among Veterans with criminal-legal involvement: A meta-analysis. Edwards ER, Fortuna A, Holliday R, Addison H, Tsai J. Clin Psychol Rev. 2025 Feb; 2024 Dec 24. PMID: 39740354.", + "Drug overdose deaths among homeless veterans in the United States Department of Veterans Affairs healthcare system. Tsai J, Szymkowiak D, Beydoun HA. Addiction. 2025 Feb; 2024 Oct 17. PMID: 39415621.", + "Characteristics of injury deaths among homeless and non-homeless US veterans (2017-2021). Beydoun HA, Szymkowiak D, Ng TKS, Tsai J. Inj Prev. 2025 Jan 27; 2025 Jan 27. PMID: 39870508.", + "Usual prevention in unusual settings: A scoping review of place-based health interventions in public-facing businesses. Tsai J, McCann NA. PLoS One. 2025; 2025 Jan 24. PMID: 39854308.", + "Comparison of Primary Care Experiences and Outpatient Health Service Utilization Among Black and Latino Homeless-Experienced Veterans: An Analysis of Patient-Centered Medical Homes. Chinchilla M, Jones AL, DeRussy A, Green MF, Gelberg L, Young AS, Tsai J, Gabrielian SE, Kertesz SG. J Prim Care Community Health. 2025 Jan-Dec; 2025 Nov 9. PMID: 41208152.", + "Rates of Prescription Fentanyl Misuse and Correlated Mental Health, Social, and Service Utilization Factors Among Adults in the United States, 2021. Stefanovics EA, Tsai J, Potenza MN. Subst Use Misuse. 2025; 2025 Jul 28. PMID: 40720299.", + "Disproportionate Increases in Numbers and Rates of Homelessness Among Women in the United States, 2018-2022. Tsai J, Lampros A. Public Health Rep. 2025 Jan-Feb; 2024 Jun 20. PMID: 38899732.", + "Pathways From Socioeconomic Factors to Major Cardiovascular Events Among Postmenopausal Veteran and Nonveteran Women: Findings From the Women's Health Initiative. Beydoun HA, Beydoun MA, Kinney RL, Liu S, Yu R, Allison M, Wallace RB, Xiao Q, Liu L, Gradidge P, Jung SY, Tindle HA, Follis S, Brunner R, Tsai J. J Am Heart Assoc. 2024 Dec 17; 2024 Dec 14. PMID: 39673348.", + "Applying Concepts of Successful Aging in Measuring and Promoting Whole Person Health. Tsai J, Jones AL. Med Care. 2024 Dec 1; 2024 Nov 11. PMID: 39514489.", + "Gambling and Substance Use Disorders in U.S. Military Veterans: Prevalence, Clinical Characteristics, and Suicide Risk. Stefanovics EA, Potenza MN, Tsai J, Pietrzak RH. J Gambl Stud. 2024 Dec; 2024 Sep 29. PMID: 39342537.", + "Correlates of six-month housing instability among U.S. adults by veteran status: Exploratory study using data from the All of Us Program. Beydoun HA, Mayno Vieytes C, Beydoun MA, Lampros A, Tsai J. PLoS One. 2024; 2024 Nov 22. PMID: 39576824.", + "Association of Homelessness and Unstable Housing With Cardiovascular Care Utilization Among Veterans. Sokoloff LJ, Wu J, Eberly LA, Nathan AS, Julien HM, Kobayashi TJ, Damrauer SM, Groeneveld PW, Tsai J, Khatana SAM. Circ Cardiovasc Qual Outcomes. 2024 Nov; 2024 Nov 4. PMID: 39492715.", + "Suicide risk evaluation among homeless veterans accessing VA health care. Holliday R, Keusch J, Monteith LL, Polzer E, Matarazzo BB, Edwards ER, Weber J, Brenner LA, Tsai J. Gen Hosp Psychiatry. 2024 Nov-Dec; 2024 Oct 9. PMID: 39406596.", + "Expanding identification of housing instability and referral to homeless programing: VA suicide risk screening and evaluation as a critical intercept. Holliday R, Polzer E, Monteith LL, Matarazzo BB, Tsai J. Gen Hosp Psychiatry. 2024 Nov-Dec; 2024 Jul 19. PMID: 39068130.", + "The translation-to-policy learning cycle to improve public health. Kilbourne AM, Braganza MZ, Bravata DM, Tsai J, Nelson RE, Meredith A, Myrie K, Ramoni R. Learn Health Syst. 2024 Oct; 2024 Oct 11. PMID: 39444498.", + "A mixed-methods study of VA video connect utilization among veterans with diabetes experiencing housing instability during the pandemic. Kinney RL, Copeland LA, Tsai J, Abbott AA, Wallace K, Walker LA, Weber J, Katsos S, McInnes DK. Digit Health. 2024 Jan-Dec; 2024 Oct 7. PMID: 39381825.", + "Why some homeless individuals are unsheltered: A narrative review of self-reported reasons. Tsai J, Haley G, Kinney RL. Soc Sci Med. 2024 Oct; 2024 Aug 8. PMID: 39168065.", + "Role of homelessness and psychiatric disorders in suicide deaths among veterans: A four-way decomposition analysis. Beydoun HA, Szymkowiak D, Pietrzak RH, Beydoun MA, Treadwell RM, Tsai J. Psychiatry Res. 2024 Oct; 2024 Aug 3. PMID: 39121758.", + "Correction: Incidence of long COVID and associated psychosocial characteristics in a large U.S. city. Tsai J, Grace A, Espinoza R, Kurian A. Soc Psychiatry Psychiatr Epidemiol. 2024 Oct. PMID: 38806743.", + "Suicide risk screening and evaluation among patients accessing VHA services and identified as being newly homeless. Holliday R, Hostetter T, Brenner LA, Bahraini N, Tsai J. Health Serv Res. 2024 Oct; 2024 Apr 8. PMID: 38590010.", + "Barriers to Mental Health Care in US Military Veterans. Lewis C, Fischer IC, Tsai J, Harpaz-Rotem I, Pietrzak RH. Psychiatr Q. 2024 Sep; 2024 Jun 28. PMID: 38940875.", + "Geographic and psychosocial correlates of homelessness or unstable housing among US veterans in the Midwest. Umucu E, Lee B, Chang C, Szymkowiak D, Tsai J. Am J Community Psychol. 2024 Sep; 2024 May 15. PMID: 38747475.", + "Growing Concern About Unsheltered Homelessness Among Veterans: Clinical Characteristics and Engagement in Health Care Services. Kinney RL, Szymkowiak D, Tsai J. Public Health Rep. 2024 Sep-Oct; 2024 Feb 7. PMID: 38323557.", + "Digital access among a national sample of currently and formerly homeless veterans in 2022. Tsai J, Lampros A, Blue-Howells J. Health Informatics J. 2024 Jul-Sep. PMID: 39167203.", + "Functional significance of posttraumatic growth in U.S. military veterans. Gower T, Fischer IC, Tsai J, Kang H, Na PJ, Tedeschi RG, Pietrzak RH. J Affect Disord. 2024 Jul 1; 2024 Apr 15. PMID: 38614442.", + "Four seasons, five regions, and other reasons for localizing laws on homelessness. Tsai J. Lancet Reg Health Am. 2024 Jun; 2024 Apr 9. PMID: 38617126.", + "The Use of Mobile Medical Units for Populations Experiencing Homelessness in the United States: A Scoping Review. Christian NJ, Havlik J, Tsai J. J Gen Intern Med. 2024 Jun; 2024 Mar 25. PMID: 38528232.", + "Prevalence and Clinical Characteristics of Recreational and At-Risk/Problematic Gambling Among Low-Income U.S. Veterans: Results from the National Veteran Homeless and Other Poverty Experiences (NV-HOPE) Study. Stefanovics EA, Potenza MN, Tsai J. J Gambl Stud. 2024 Jun; 2023 Sep 26. PMID: 37751035.", + "Obesity in U.S. low-income veterans:Prevalence, clinical characteristics, and homelessness. Stefanovics EA, Potenza MN, Tsai J. J Psychiatr Res. 2024 May; 2024 Mar 27. PMID: 38574595.", + "Sustained mental health and functional responses to the COVID-19 pandemic in Black and White Veterans with psychosis or recent homelessness. Novacek DM, Wynn JK, McCleery A, Reavis EA, Senturk D, Sugar CA, Tsai J, Green MF. J Psychiatr Res. 2024 Apr; 2024 Feb 15. PMID: 38373371.", + "Use and Interest in Virtual Reality for Mental and Physical Health in a U.S. Population-Based Sample of Low-Income Veterans. Tsai J. Cyberpsychol Behav Soc Netw. 2024 Apr; 2024 Feb 15. PMID: 38359391.", + "Incidence of long COVID and associated psychosocial characteristics in a large U.S. city. Tsai J, Grace A, Espinoza R, Kurian A. Soc Psychiatry Psychiatr Epidemiol. 2024 Apr; 2023 Aug 22. PMID: 37606649.", + "The mediating role of social support in associations between childhood adversity, military sexual trauma, and homelessness in a nationally representative sample of US veterans. Bulanchuk N, Edwards E, Pietrzak RH, Tsai J. J Community Psychol. 2024 Mar; 2024 Jan 30. PMID: 38289875.", + "Posttraumatic Growth in U.S. Military Veterans: Results from the National Health and Resilience in Veterans Study. Kang H, Fischer IC, Dickinson S, Na PJ, Tsai J, Tedeschi RG, Pietrzak RH. Psychiatr Q. 2024 Mar; 2023 Nov 8. PMID: 37938492.", + "A Research Agenda for Criminal Justice Involvement Among U.S. Veterans. Tsai J, Kelton K, Blonigen DM, Keith Mcinnes D, Sean Clark, Blue-Howells J, Hooshyar D. Mil Med. 2024 Feb 27. PMID: 37283229.", + "Incidence and psychiatric predictors of Long COVID beyond 3 months in a city-wide community sample in Texas. Tsai J, Grace A, Kurian A. J Public Health (Oxf). 2024 Feb 23. PMID: 38141051.", + "Underdiagnosis of Postpartum Disorders Across Ethnic Groups. Athanasiadi A, Chyung D, Tsai J. Psychiatr Serv. 2024 Feb 1. PMID: 38298113.", + "Distribution of CARES Act Provider Relief Funding to Psychiatric Care Organizations. Havlik JL, Wahid S, Ososanya L, Tang D, Lee MS, Tsai J. Psychiatr Serv. 2024 Feb 1; 2023 Sep 7. PMID: 37674396.", + "A systematic review of approaches to improve medication adherence in homeless adults with psychiatric disorders. Hird R, Radhakrishnan R, Tsai J. Front Psychiatry. 2023; 2024 Jan 8. PMID: 38260790.", + "Beyond the Usual Players: Evidence-Building Priorities for Behavioral Health Among all U.S. Federal Agencies. Tsai J. Adm Policy Ment Health. 2024 Jan; 2023 Oct 20. PMID: 37861856.", + "The impact of psychological strengths on Veteran populations' mental health trajectories during the COVID-19 pandemic. McCleery A, Wynn JK, Novacek DM, Reavis EA, Senturk D, Sugar CA, Tsai J, Green MF. Soc Psychiatry Psychiatr Epidemiol. 2024 Jan; 2023 Jun 14. PMID: 37314492.", + "Self-reported Impacts of the COVID-19 Pandemic and Economic Inflation on the Well-being of Low-income U.S. Veterans. Tsai J, Hird R, Collier A. J Community Health. 2023 Dec; 2023 Aug 21. PMID: 37605100.", + "Firearm Ownership Among a Nationally Representative Sample of U.S. Veterans. Fischer IC, Aunon FM, Nichter B, Hill ML, Panza KE, Kline AC, Na PJ, Tsai J, Harpaz-Rotem I, Pietrzak RH. Am J Prev Med. 2023 Dec; 2023 Jun 23. PMID: 37354925.", + "Not all traumas are created equal: Phenotypic heterogeneity of PTSD symptoms in relation to index traumas in U.S. military veterans. Kachadourian LK, Duek O, Tsai J, Harpaz-Rotem I, Pietrzak RH. J Affect Disord. 2023 Nov 1; 2023 Aug 11. PMID: 37572698.", + "Purpose in life protects against the development of suicidal thoughts and behaviors in U.S. veterans without a history of suicidality: A 10-year, nationally representative, longitudinal study. Fischer IC, Nichter B, Feldman DB, Na PJ, Tsai J, Harpaz-Rotem I, Schulenberg SE, Pietrzak RH. J Affect Disord. 2023 Nov 1; 2023 Aug 7. PMID: 37557988.", + "Is it Time to Antiquate the Term \"Landlord?\". Tsai J. J Urban Health. 2023 Oct; 2023 Sep 25. PMID: 37747651.", + "Identifying significant correlates of purpose in life in older US military veterans: results from the national health and resilience in veterans study. Fischer IC, Feldman DB, Tsai J, Harpaz-Rotem I, Lucas KA, Schulenberg SE, Pietrzak RH. Int Psychogeriatr. 2023 Oct; 2023 Jan 30. PMID: 36715004.", + "A Small Randomized Controlled Trial of Three Remote Methods to Collect Mental Health Data from Migrant Farmworker Adults. Tsai J, Rodriguez A, Solis V. J Immigr Minor Health. 2023 Oct; 2023 Jan 30. PMID: 36710300.", + "Emergency Department Use Among Recently Homeless Adults in a Nationally Representative Sample. Ryus C, Stefanovics E, Tsai J, Rhee TG, Rosenheck RA. West J Emerg Med. 2023 Sep. PMID: 37788030.", + "Changes in mental health among U.S. military veterans during the COVID-19 pandemic: A network analysis. Spiller TR, Na PJ, Merians AN, Duek O, Ben-Zion Z, Tsai J, von Känel R, Harpaz-Rotem I, Pietrzak RH. J Psychiatr Res. 2023 Sep; 2023 Aug 11. PMID: 37595331.", + "Prevalence and Clinical Characteristics of Recreational and At-Risk/Problematic Gambling in a National Sample of U.S. Military Veterans. Stefanovics EA, Potenza MN, Tsai J, Pietrzak RH. J Gambl Stud. 2023 Sep; 2022 Nov 15. PMID: 36378356.", + "Erectile Dysfunction in a U.S. National Sample of Male Military Veterans. Way BM, Griffin KR, Kraus SW, Tsai J, Pietrzak RH. Mil Med. 2023 Aug 29. PMID: 35792506.", + "Pandemic-related posttraumatic psychological growth in U.S. military veterans: A 3-year, nationally representative, longitudinal study. Kang H, Na PJ, Fischer IC, Tsai J, Tedeschi RG, Pietrzak RH. Psychiatry Res. 2023 Aug; 2023 Jul 24. PMID: 37499281.", + "Chronically homeless veterans with gambling disorder: Epidemiology, clinical correlates, and traumatic experiences. Stefanovics EA, Potenza MN, Szymkowiak D, Tsai J. J Psychiatr Res. 2023 Aug; 2023 Jun 9. PMID: 37339548.", + "Prospective Associations of Military Discharge Characterization with Post-active Duty Suicide Attempts and Homelessness: Results from the Study to Assess Risk and Resilience in Servicemembers-Longitudinal Study (STARRS-LS). Naifeh JA, Capaldi VF, Chu C, King AJ, Koh KA, Marx BP, Montgomery AE, O'Brien RW, Sampson NA, Stanley IH, Tsai J, Vogt D, Ursano RJ, Stein MB, Kessler RC. Mil Med. 2023 Jul 22. PMID: 35943145.", + "Automated identification of eviction status from electronic health record notes. Yao Z, Tsai J, Liu W, Levy DA, Druhl E, Reisman JI, Yu H. J Am Med Inform Assoc. 2023 Jul 19. PMID: 37203429.", + "Prevalence, correlates, and mental health burden associated with homelessness in U.S. military veterans. Nichter B, Tsai J, Pietrzak RH. Psychol Med. 2023 Jul; 2022 Mar 18. PMID: 35301973.", + "Purpose in life and physical health in older U.S. military veterans: Cross-sectional results from the National Health and Resilience in Veterans Study. Fischer IC, Feldman DB, Tsai J, Harpaz-Rotem I, McCutcheon VE, Schulenberg SE, Pietrzak RH. Prev Med. 2023 May; 2023 Mar 29. PMID: 37001606.", + "Factors related to COVID-19 vaccine hesitancy among middle-income and low-income adults in the USA. Nguyen VT, Huang Y, Huang M, Tsai J. J Epidemiol Community Health. 2023 May; 2023 Mar 8. PMID: 36889909.", + "Evaluating Veterans Response Teams and Police Interventions on Veterans' Health Care Utilization. Tsai J, Gonzalez C, Szymkowiak D, Stewart K, Dillard D, Whittle T, Woodland P. J Public Health Manag Pract. 2023 May-Jun 01; 2023 Mar 3. PMID: 36867527.", + "Sex-specific risk and resilience correlates of suicidal ideation in U.S. military veterans. Stefanovics EA, Potenza MN, Tsai J, Nichter B, Pietrzak RH. J Affect Disord. 2023 May 1; 2023 Feb 10. PMID: 36775254.", + "Identifying Graduation Rates and Practices in the U.S. Department of Housing and Urban Development-Veterans Affairs Supportive Housing Program. Tsai J, Byrne T, Hill LL, Flatley B, Harelik N, Deal M. Community Ment Health J. 2023 May; 2022 Nov 22. PMID: 36417137.", + "Prevalence and characteristics associated with firearm ownership among low-income U.S. veterans. Tsai J, Testa A, Pietrzak RH, Elbogen EB. Mil Psychol. 2023 Mar-Apr; 2022 Jun 10. PMID: 37133491.", + "Beyond Supported Housing: Correlates of Improvements in Quality of Life Among Homeless Adults with Mental Illness. O'Connell M, Tsai J, Rosenheck R. Psychiatr Q. 2023 Mar; 2022 Dec 20. PMID: 36538200.", + "City-wide study of laboratory-confirmed COVID-19 cases in San Antonio: An investigation of stressful events accompanying infection and their relation to psychosocial functioning. Tsai J, Grace A, North CS, Pietrzak RH, Vazquez M, Kurian A. Psychiatry Res. 2023 Feb; 2022 Dec 20. PMID: 36565515.", + "Primary Care for Veterans Experiencing Homelessness: a Narrative Review of the Homeless Patient Aligned Care Team (HPACT) Model. Tsai J, Havlik J, Howell BA, Johnson E, Rosenthal D. J Gen Intern Med. 2023 Feb; 2022 Nov 28. PMID: 36443628.", + "Perceived Purpose in Life, Mental Health, and Suicidality in Older U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study. Fischer IC, Tsai J, Harpaz-Rotem I, McCutcheon VE, Schulenberg SE, Pietrzak RH. Am J Geriatr Psychiatry. 2023 Feb; 2022 Sep 24. PMID: 36253289.", + "Job Automation and Concerns During the COVID-19 Pandemic Among Middle and Low-Income US Adults. Tsai J, Umucu E, Fish K. J Occup Environ Med. 2023 Feb 1; 2022 Oct 17. PMID: 36240751.", + "Medical Care Needs of Laundromat Users in San Antonio, Texas: A Potentially Unique Setting for Health Interventions. Tsai J, Solis V, Schick V. J Community Health. 2023 Feb; 2022 Aug 25. PMID: 36006533.", + "VA Connecticut Healthcare 950 Campbell Avenue West Haven, CT 06516", + "Calendar", + "Contact Us", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Tumor Neuroimmunology Lab", + "lab_url": "https://medicine.yale.edu/lab/tumor-neuroimmunology-lab/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/tumor-neuroimmunology-lab/publications", + "publications": null + }, + { + "lab_name": "Turk Lab", + "lab_url": "https://medicine.yale.edu/lab/turk/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/turk/publications/", + "publications": [ + "Yale School of Medicine /", + "Pharmacology /", + "News", + "Contact", + "Research", + "Lab Members", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "News", + "Research", + "Lab Members", + "Publications", + "Contact", + "", + "", + "", + "", + "", + "", + "Mouth Breathing and Orthodontic Referral in Pediatric Practice: A Cross-Sectional Survey. Büyükpatır Türk T, Türk BE, Kaya Y. Children (Basel). 2025 Jun 17; 2025 Jun 17. PMID: 40564748.", + "Cancer hotspot mutations rewire ERK2 specificity by selective exclusion of docking interactions. Torres Robles J, Stiegler AL, Boggon TJ, Turk BE. J Biol Chem. 2025 Apr; 2025 Feb 25. PMID: 40015635.", + "Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma. McGeary MK, Damsky W, Daniels AJ, Lang SM, Xu Q, Song E, Huet-Calderwood C, Lou HJ, Paradkar S, Micevic G, Kaech SM, Calderwood DA, Turk BE, Yan Q, Iwasaki A, Bosenberg MW. Cancer Immunol Res. 2025 Feb 3. PMID: 39589394.", + "Aurora B controls anaphase onset and error-free chromosome segregation in trypanosomes. Ballmer D, Lou HJ, Ishii M, Turk BE, Akiyoshi B. J Cell Biol. 2024 Nov 4; 2024 Aug 28. PMID: 39196069.", + "Protein phosphatase 6 activates NF-κB to confer sensitivity to MAPK pathway inhibitors in KRAS- and BRAF-mutant cancer cells. Zhang H, Read A, Cataisson C, Yang HH, Lee WC, Turk BE, Yuspa SH, Luo J. Sci Signal. 2024 May 14; 2024 May 14. PMID: 38743809.", + "The intrinsic substrate specificity of the human tyrosine kinome. Yaron-Barir TM, Joughin BA, Huntsman EM, Kerelsky A, Cizin DM, Cohen BM, Regev A, Song J, Vasan N, Lin TY, Orozco JM, Schoenherr C, Sagum C, Bedford MT, Wynn RM, Tso SC, Chuang DT, Li L, Li SS, Creixell P, Krismer K, Takegami M, Lee H, Zhang B, Lu J, Cossentino I, Landry SD, Uduman M, Blenis J, Elemento O, Frame MC, Hornbeck PV, Cantley LC, Turk BE, Yaffe MB, Johnson JL. Nature. 2024 May; 2024 May 8. PMID: 38720073.", + "Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail. Sexton JA, Potchernikov T, Bibeau JP, Casanova-Sepúlveda G, Cao W, Lou HJ, Boggon TJ, De La Cruz EM, Turk BE. Nat Commun. 2024 Feb 16; 2024 Feb 16. PMID: 38365893.", + "An unconventional regulatory circuitry involving Aurora B controls anaphase onset and error-free chromosome segregation in trypanosomes. Ballmer D, Lou HJ, Ishii M, Turk BE, Akiyoshi B. bioRxiv. 2024 Jan 20; 2024 Jan 20. PMID: 38293145.", + "Autoregulation of the LIM kinases by their PDZ domain. Casanova-Sepúlveda G, Sexton JA, Turk BE, Boggon TJ. Nat Commun. 2023 Dec 19; 2023 Dec 19. PMID: 38114480.", + "Linear motif specificity in signaling through p38α and ERK2 mitogen-activated protein kinases. Torres Robles J, Lou HJ, Shi G, Pan PL, Turk BE. Proc Natl Acad Sci U S A. 2023 Nov 28; 2023 Nov 21. PMID: 37988460.", + "Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail. Sexton JA, Potchernikov T, Bibeau JP, Casanova-Sepúlveda G, Cao W, Lou HJ, Boggon TJ, De La Cruz EM, Turk BE. bioRxiv. 2023 Jul 9; 2023 Jul 9. PMID: 37425676.", + "An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells. Zhou W, Li W, Wang S, Salovska B, Hu Z, Tao B, Di Y, Punyamurtula U, Turk BE, Sessa WC, Liu Y. Nat Commun. 2023 Jun 26; 2023 Jun 26. PMID: 37365174.", + "Setdb1 -loss induces type-I interferons and immune clearance of melanoma. McGeary MK, Damsky W, Daniels A, Song E, Micevic G, Huet-Calderwood C, Lou HJ, Paradkar S, Kaech S, Calderwood DA, Turk BE, Iwasaki A, Bosenberg MW. bioRxiv. 2023 May 24; 2023 May 24. PMID: 37292991.", + "Proteome-wide screening for mitogen-activated protein kinase docking motifs and interactors. Shi G, Song C, Torres Robles J, Salichos L, Lou HJ, Lam TT, Gerstein M, Turk BE. Sci Signal. 2023 Jan 10; 2023 Jan 10. PMID: 36626580.", + "An atlas of substrate specificities for the human serine/threonine kinome. Johnson JL, Yaron TM, Huntsman EM, Kerelsky A, Song J, Regev A, Lin TY, Liberatore K, Cizin DM, Cohen BM, Vasan N, Ma Y, Krismer K, Robles JT, van de Kooij B, van Vlimmeren AE, Andrée-Busch N, Käufer NF, Dorovkov MV, Ryazanov AG, Takagi Y, Kastenhuber ER, Goncalves MD, Hopkins BD, Elemento O, Taatjes DJ, Maucuer A, Yamashita A, Degterev A, Uduman M, Lu J, Landry SD, Zhang B, Cossentino I, Linding R, Blenis J, Hornbeck PV, Turk BE, Yaffe MB, Cantley LC. Nature. 2023 Jan; 2023 Jan 11. PMID: 36631611.", + "Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism. Stork BA, Dean A, Ortiz AR, Saha P, Putluri N, Planas-Silva MD, Mahmud I, Rajapakshe K, Coarfa C, Knapp S, Lorenzi PL, Kemp BE, Turk BE, Scott JW, Means AR, York B. Mol Metab. 2022 Aug; 2022 May 11. PMID: 35562082.", + "Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry. Simon B, Lou HJ, Huet-Calderwood C, Shi G, Boggon TJ, Turk BE, Calderwood DA. Nat Commun. 2022 Feb 8; 2022 Feb 8. PMID: 35136069.", + "Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function. Schiapparelli P, Pirman NL, Mohler K, Miranda-Herrera PA, Zarco N, Kilic O, Miller C, Shah SR, Rogulina S, Hungerford W, Abriola L, Hoyer D, Turk BE, Guerrero-Cázares H, Isaacs FJ, Quiñones-Hinojosa A, Levchenko A, Rinehart J. Cell Rep. 2021 Jul 20. PMID: 34289367.", + "TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin. Torres-Ayuso P, An E, Nyswaner KM, Bensen RC, Ritt DA, Specht SI, Das S, Andresson T, Cachau RE, Liang RJ, Ries AL, Robinson CM, Difilippantonio S, Gouker B, Bassel L, Karim BO, Miller CJ, Turk BE, Morrison DK, Brognard J. Cancer Discov. 2021 Jun; 2021 Jan 25. PMID: 33495197.", + "Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast. Ghosh C, Uppala JK, Sathe L, Hammond CI, Anshu A, Pokkuluri PR, Turk BE, Dey M. Sci Signal. 2021 May 25; 2021 May 25. PMID: 34035143.", + "PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK. Cho E, Lou HJ, Kuruvilla L, Calderwood DA, Turk BE. Cell Rep. 2021 Mar 30. PMID: 33789117.", + "Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting. Komolov KE, Sulon SM, Bhardwaj A, van Keulen SC, Duc NM, Laurinavichyute DK, Lou HJ, Turk BE, Chung KY, Dror RO, Benovic JL. Mol Cell. 2021 Jan 21; 2020 Dec 14. PMID: 33321095.", + "Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association. Zhou M, Kuruvilla L, Shi X, Viviano S, Ahearn IM, Amendola CR, Su W, Badri S, Mahaffey J, Fehrenbacher N, Skok J, Schlessinger J, Turk BE, Calderwood DA, Philips MR. Proc Natl Acad Sci U S A. 2020 Dec 15; 2020 Nov 30. PMID: 33257571.", + "Recognition of physiological phosphorylation sites by p21-activated kinase 4. Chetty AK, Sexton JA, Ha BH, Turk BE, Boggon TJ. J Struct Biol. 2020 Sep 1; 2020 Jun 23. PMID: 32585314.", + "A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding. Terekhov SS, Mokrushina YA, Nazarov AS, Zlobin A, Zalevsky A, Bourenkov G, Golovin A, Belogurov A Jr, Osterman IA, Kulikova AA, Mitkevich VA, Lou HJ, Turk BE, Wilmanns M, Smirnov IV, Altman S, Gabibov AG. Sci Adv. 2020 Jun; 2020 Jun 24. PMID: 32637600.", + "Ancestral reconstruction reveals mechanisms of ERK regulatory evolution. Sang D, Pinglay S, Wiewiora RP, Selvan ME, Lou HJ, Chodera JD, Turk BE, Gümüş ZH, Holt LJ. Elife. 2019 Aug 13; 2019 Aug 13. PMID: 31407663.", + "Global view of the RAF-MEK-ERK module and its immediate downstream effectors. Santini CC, Longden J, Schoof EM, Simpson CD, Jeschke GR, Creixell P, Kim J, Wu X, Turk BE, Rosen N, Poulikakos PI, Linding R. Sci Rep. 2019 Jul 26; 2019 Jul 26. PMID: 31350469.", + "Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs. van de Kooij B, Creixell P, van Vlimmeren A, Joughin BA, Miller CJ, Haider N, Simpson CD, Linding R, Stambolic V, Turk BE, Yaffe MB. Elife. 2019 May 24; 2019 May 24. PMID: 31124786.", + "Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output. Miller CJ, Lou HJ, Simpson C, van de Kooij B, Ha BH, Fisher OS, Pirman NL, Boggon TJ, Rinehart J, Yaffe MB, Linding R, Turk BE. PLoS Biol. 2019 Mar; 2019 Mar 21. PMID: 30897078.", + "Plasmodium falciparum Cyclic GMP-Dependent Protein Kinase Interacts with a Subunit of the Parasite Proteasome. Govindasamy K, Khan R, Snyder M, Lou HJ, Du P, Kudyba HM, Muralidharan V, Turk BE, Bhanot P. Infect Immun. 2019 Jan; 2018 Dec 19. PMID: 30323024.", + "Exceptionally Selective Substrate Targeting by the Metalloprotease Anthrax Lethal Factor. Turk BE. Adv Exp Med Biol. 2019. PMID: 30267305.", + "Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells. Waldt N, Seifert A, Demiray YE, Devroe E, Turk BE, Reichardt P, Mix C, Reinhold A, Freund C, Müller AJ, Schraven B, Stork O, Kliche S. Front Immunol. 2018; 2018 Dec 4. PMID: 30568657.", + "Substrate priming enhances phosphorylation by the budding yeast kinases Kin1 and Kin2. Jeschke GR, Lou HJ, Weise K, Hammond CI, Demonch M, Brennwald P, Turk BE. J Biol Chem. 2018 Nov 23; 2018 Oct 10. PMID: 30305396.", + "Kinase Substrate Profiling Using a Proteome-wide Serine-Oriented Human Peptide Library. Barber KW, Miller CJ, Jun JW, Lou HJ, Turk BE, Rinehart J. Biochemistry. 2018 Aug 7; 2018 Jun 19. PMID: 29920078.", + "Homing in: Mechanisms of Substrate Targeting by Protein Kinases. Miller CJ, Turk BE. Trends Biochem Sci. 2018 May; 2018 Mar 12. PMID: 29544874.", + "In Silico Design and in Vitro Characterization of Universal Tyrosine Kinase Peptide Substrates. Marholz LJ, Zeringo NA, Lou HJ, Turk BE, Parker LL. Biochemistry. 2018 Mar 27; 2018 Mar 12. PMID: 29528224.", + "Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition. Hara M, Lourido S, Petrova B, Lou HJ, Von Stetina JR, Kashevsky H, Turk BE, Orr-Weaver TL. Elife. 2018 Feb 26; 2018 Feb 26. PMID: 29480805.", + "Glycogen synthase kinase-3β regulation: another kinase gets in on the AKT. Turk BE. FEBS Lett. 2018 Feb; 2018 Feb 8. PMID: 29417553.", + "A high throughput assay to identify substrate-selective inhibitors of the ERK protein kinases. Miller CJ, Muftuoglu Y, Turk BE. Biochem Pharmacol. 2017 Oct 15; 2017 Jun 21. PMID: 28647489.", + "Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine. Advani G, Lim YC, Catimel B, Lio DSS, Ng NLY, Chüeh AC, Tran M, Anasir MI, Verkade H, Zhu HJ, Turk BE, Smithgall TE, Ang CS, Griffin M, Cheng HC. Cell Commun Signal. 2017 Aug 7; 2017 Aug 7. PMID: 28784162.", + "Rational Redesign of a Functional Protein Kinase-Substrate Interaction. Chen C, Nimlamool W, Miller CJ, Lou HJ, Turk BE. ACS Chem Biol. 2017 May 19; 2017 Mar 29. PMID: 28314095.", + "Ssp2 Binding Activates the Smk1 Mitogen-Activated Protein Kinase. Tio CW, Omerza G, Phillips T, Lou HJ, Turk BE, Winter E. Mol Cell Biol. 2017 May 15; 2017 May 2. PMID: 28223369.", + "Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop. Cobbaut M, Derua R, Döppler H, Lou HJ, Vandoninck S, Storz P, Turk BE, Seufferlein T, Waelkens E, Janssens V, Van Lint J. Sci Rep. 2017 Apr 20; 2017 Apr 20. PMID: 28428613.", + "Identification of a Substrate-selective Exosite within the Metalloproteinase Anthrax Lethal Factor. Goldberg AB, Cho E, Miller CJ, Lou HJ, Turk BE. J Biol Chem. 2017 Jan 20; 2016 Dec 1. PMID: 27909054.", + "Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms. Shi X, Mihaylova VT, Kuruvilla L, Chen F, Viviano S, Baldassarre M, Sperandio D, Martinez R, Yue P, Bates JG, Breckenridge DG, Schlessinger J, Turk BE, Calderwood DA. Proc Natl Acad Sci U S A. 2016 Aug 2; 2016 Jul 18. PMID: 27432991.", + "Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib. Mathea S, Abdul Azeez KR, Salah E, Tallant C, Wolfreys F, Konietzny R, Fischer R, Lou HJ, Brennan PE, Schnapp G, Pautsch A, Kessler BM, Turk BE, Knapp S. ACS Chem Biol. 2016 Jun 17; 2016 Mar 31. PMID: 26999302.", + "Control of serotonin transporter phosphorylation by conformational state. Zhang YW, Turk BE, Rudnick G. Proc Natl Acad Sci U S A. 2016 May 17; 2016 May 2. PMID: 27140629.", + "Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases. Hamill S, Lou HJ, Turk BE, Boggon TJ. Mol Cell. 2016 May 5. PMID: 27153537.", + "Inhibitors of the Metalloproteinase Anthrax Lethal Factor. Goldberg AB, Turk BE. Curr Top Med Chem. 2016. PMID: 27072692.", + "Rapid Identification of Protein Kinase Phosphorylation Site Motifs Using Combinatorial Peptide Libraries. Miller CJ, Turk BE. Methods Mol Biol. 2016. PMID: 26501912.", + "Analysis of Protein Tyrosine Kinase Specificity Using Positional Scanning Peptide Microarrays. Deng Y, Turk BE. Methods Mol Biol. 2016. PMID: 26490465.", + "Unmasking determinants of specificity in the human kinome. Creixell P, Palmeri A, Miller CJ, Lou HJ, Santini CC, Nielsen M, Turk BE, Linding R. Cell. 2015 Sep 24; 2015 Sep 17. PMID: 26388442.", + "Kinome-wide decoding of network-attacking mutations rewiring cancer signaling. Creixell P, Schoof EM, Simpson CD, Longden J, Miller CJ, Lou HJ, Perryman L, Cox TR, Zivanovic N, Palmeri A, Wesolowska-Andersen A, Helmer-Citterich M, Ferkinghoff-Borg J, Itamochi H, Bodenmiller B, Erler JT, Turk BE, Linding R. Cell. 2015 Sep 24; 2015 Sep 17. PMID: 26388441.", + "Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK. Ronkina N, Johansen C, Bohlmann L, Lafera J, Menon MB, Tiedje C, Laaß K, Turk BE, Iversen L, Kotlyarov A, Gaestel M. PLoS One. 2015; 2015 Aug 21. PMID: 26295581.", + "Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ, Su B. Nat Commun. 2015 Aug 3; 2015 Aug 3. PMID: 26235885.", + "Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates. Egan DF, Chun MG, Vamos M, Zou H, Rong J, Miller CJ, Lou HJ, Raveendra-Panickar D, Yang CC, Sheffler DJ, Teriete P, Asara JM, Turk BE, Cosford ND, Shaw RJ. Mol Cell. 2015 Jul 16; 2015 Jun 25. PMID: 26118643.", + "Biochemical characterization of FIKK8--A unique protein kinase from the malaria parasite Plasmodium falciparum and other apicomplexans. Osman KT, Lou HJ, Qiu W, Brand V, Edwards AM, Turk BE, Hui R. Mol Biochem Parasitol. 2015 Jun; 2015 Jun 22. PMID: 26112892.", + "Signaling, Regulation, and Specificity of the Type II p21-activated Kinases. Ha BH, Morse EM, Turk BE, Boggon TJ. J Biol Chem. 2015 May 22; 2015 Apr 8. PMID: 25855792.", + "Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity. Howard CJ, Hanson-Smith V, Kennedy KJ, Miller CJ, Lou HJ, Johnson AD, Turk BE, Holt LJ. Elife. 2014 Oct 13; 2014 Oct 13. PMID: 25310241.", + "Global analysis of human nonreceptor tyrosine kinase specificity using high-density peptide microarrays. Deng Y, Alicea-Velázquez NL, Bannwarth L, Lehtonen SI, Boggon TJ, Cheng HC, Hytönen VP, Turk BE. J Proteome Res. 2014 Oct 3; 2014 Aug 28. PMID: 25164267.", + "Identification of cleavage sites leading to the shed form of the anti-aging protein klotho. Chen CD, Tung TY, Liang J, Zeldich E, Tucker Zhou TB, Turk BE, Abraham CR. Biochemistry. 2014 Sep 2; 2014 Aug 20. PMID: 25110992.", + "An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential. Goodwin JM, Svensson RU, Lou HJ, Winslow MM, Turk BE, Shaw RJ. Mol Cell. 2014 Aug 7; 2014 Jul 17. PMID: 25042806.", + "Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3. Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, Jeschke GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PP. Proc Natl Acad Sci U S A. 2014 Jul 22; 2014 Jul 7. PMID: 25002506.", + "Modulation of the chromatin phosphoproteome by the Haspin protein kinase. Maiolica A, de Medina-Redondo M, Schoof EM, Chaikuad A, Villa F, Gatti M, Jeganathan S, Lou HJ, Novy K, Hauri S, Toprak UH, Herzog F, Meraldi P, Penengo L, Turk BE, Knapp S, Linding R, Aebersold R. Mol Cell Proteomics. 2014 Jul; 2014 Apr 14. PMID: 24732914.", + "The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice. Etheridge RD, Alaganan A, Tang K, Lou HJ, Turk BE, Sibley LD. Cell Host Microbe. 2014 May 14. PMID: 24832449.", + "Early steps in autophagy depend on direct phosphorylation of Atg9 by the Atg1 kinase. Papinski D, Schuschnig M, Reiter W, Wilhelm L, Barnes CA, Maiolica A, Hansmann I, Pfaffenwimmer T, Kijanska M, Stoffel I, Lee SS, Brezovich A, Lou JH, Turk BE, Aebersold R, Ammerer G, Peter M, Kraft C. Mol Cell. 2014 Feb 6; 2014 Jan 16. PMID: 24440502.", + "Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity. Chen C, Ha BH, Thévenin AF, Lou HJ, Zhang R, Yip KY, Peterson JR, Gerstein M, Kim PM, Filippakopoulos P, Knapp S, Boggon TJ, Turk BE. Mol Cell. 2014 Jan 9; 2013 Dec 26. PMID: 24374310.", + "Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6. Gao J, Ha BH, Lou HJ, Morse EM, Zhang R, Calderwood DA, Turk BE, Boggon TJ. PLoS One. 2013; 2013 Oct 28. PMID: 24204982.", + "mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM. Science. 2013 Jul 26. PMID: 23888043.", + "Coupling protein engineering with probe design to inhibit and image matrix metalloproteinases with controlled specificity. Morell M, Nguyen Duc T, Willis AL, Syed S, Lee J, Deu E, Deng Y, Xiao J, Turk BE, Jessen JR, Weiss SJ, Bogyo M. J Am Chem Soc. 2013 Jun 19; 2013 Jun 6. PMID: 23701445.", + "Construction of human activity-based phosphorylation networks. Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Clark HM, Hu S, Hwang W, Jeong JS, Wu G, Lin J, Gao X, Ni Q, Goel R, Xia S, Ji H, Dalby KN, Birnbaum MJ, Cole PA, Knapp S, Ryazanov AG, Zack DJ, Blackshaw S, Pawson T, Gingras AC, Desiderio S, Pandey A, Turk BE, Zhang J, Zhu H, Qian J. Mol Syst Biol. 2013. PMID: 23549483.", + "Exploiting the unique ATP-binding pocket of toxoplasma calcium-dependent protein kinase 1 to identify its substrates. Lourido S, Jeschke GR, Turk BE, Sibley LD. ACS Chem Biol. 2013; 2013 Apr 10. PMID: 23530747.", + "A peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase. Deng Y, Couch BA, Koleske AJ, Turk BE. Chembiochem. 2012 Nov 26; 2012 Oct 18. PMID: 23081945.", + "Reciprocal phosphorylation of yeast glycerol-3-phosphate dehydrogenases in adaptation to distinct types of stress. Lee YJ, Jeschke GR, Roelants FM, Thorner J, Turk BE. Mol Cell Biol. 2012 Nov; 2012 Sep 17. PMID: 22988299.", + "Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase. Shehata SN, Hunter RW, Ohta E, Peggie MW, Lou HJ, Sicheri F, Zeqiraj E, Turk BE, Sakamoto K. Cell Signal. 2012 Nov; 2012 Jul 11. PMID: 22796189.", + "Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase. Wong A, Zhang YW, Jeschke GR, Turk BE, Rudnick G. J Biol Chem. 2012 Oct 19; 2012 Aug 31. PMID: 22942288.", + "Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Ha BH, Davis MJ, Chen C, Lou HJ, Gao J, Zhang R, Krauthammer M, Halaban R, Schlessinger J, Turk BE, Boggon TJ. Proc Natl Acad Sci U S A. 2012 Oct 2; 2012 Sep 17. PMID: 22988085.", + "Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening. Bannwarth L, Goldberg AB, Chen C, Turk BE. Chem Biol. 2012 Jul 27. PMID: 22840775.", + "Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking. Strochlic TI, Concilio S, Viaud J, Eberwine RA, Wong LE, Minden A, Turk BE, Plomann M, Peterson JR. Proc Natl Acad Sci U S A. 2012 Mar 13; 2012 Feb 27. PMID: 22371566.", + "Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli. Abramczyk O, Tavares CD, Devkota AK, Ryazanov AG, Turk BE, Riggs AF, Ozpolat B, Dalby KN. Protein Expr Purif. 2011 Oct; 2011 May 14. PMID: 21605678.", + "Identification of specificity determining residues in peptide recognition domains using an information theoretic approach applied to large-scale binding maps. Yip KY, Utz L, Sitwell S, Hu X, Sidhu SS, Turk BE, Gerstein M, Kim PM. BMC Biol. 2011 Aug 11; 2011 Aug 11. PMID: 21835011.", + "Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate. Ia KK, Jeschke GR, Deng Y, Kamaruddin MA, Williamson NA, Scanlon DB, Culvenor JG, Hossain MI, Purcell AW, Liu S, Zhu HJ, Catimel B, Turk BE, Cheng HC. Biochemistry. 2011 Aug 9; 2011 Jul 18. PMID: 21699177.", + "Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation. Kikani CK, Antonysamy SA, Bonanno JB, Romero R, Zhang FF, Russell M, Gheyi T, Iizuka M, Emtage S, Sauder JM, Turk BE, Burley SK, Rutter J. J Biol Chem. 2010 Dec 24; 2010 Oct 13. PMID: 20943661.", + "Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence. Fentress SJ, Behnke MS, Dunay IR, Mashayekhi M, Rommereim LM, Fox BA, Bzik DJ, Taylor GA, Turk BE, Lichti CF, Townsend RR, Qiu W, Hui R, Beatty WL, Sibley LD. Cell Host Microbe. 2010 Dec 16. PMID: 21147463.", + "The Arabidopsis ABA-activated kinase OST1 phosphorylates the bZIP transcription factor ABF3 and creates a 14-3-3 binding site involved in its turnover. Sirichandra C, Davanture M, Turk BE, Zivy M, Valot B, Leung J, Merlot S. PLoS One. 2010 Nov 10; 2010 Nov 10. PMID: 21085673.", + "Analysis of serine-threonine kinase specificity using arrayed positional scanning peptide libraries. Chen C, Turk BE. Curr Protoc Mol Biol. 2010 Jul. PMID: 20583094.", + "MOTIPS: automated motif analysis for predicting targets of modular protein domains. Lam HY, Kim PM, Mok J, Tonikian R, Sidhu SS, Turk BE, Snyder M, Gerstein MB. BMC Bioinformatics. 2010 May 11; 2010 May 11. PMID: 20459839.", + "Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, Manolopoulou M, Tang WJ, Stein RL, Cuny GD, Selkoe DJ. PLoS One. 2010 May 7; 2010 May 7. PMID: 20498699.", + "Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Mok J, Kim PM, Lam HY, Piccirillo S, Zhou X, Jeschke GR, Sheridan DL, Parker SA, Desai V, Jwa M, Cameroni E, Niu H, Good M, Remenyi A, Ma JL, Sheu YJ, Sassi HE, Sopko R, Chan CS, De Virgilio C, Hollingsworth NM, Lim WA, Stern DF, Stillman B, Andrews BJ, Gerstein MB, Snyder M, Turk BE. Sci Signal. 2010 Feb 16; 2010 Feb 16. PMID: 20159853.", + "Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10. Caescu CI, Jeschke GR, Turk BE. Biochem J. 2009 Oct 23; 2009 Oct 23. PMID: 19715556.", + "Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases. Davis TL, Walker JR, Allali-Hassani A, Parker SA, Turk BE, Dhe-Paganon S. FEBS J. 2009 Aug. PMID: 19678838.", + "Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation. Bullock AN, Das S, Debreczeni JE, Rellos P, Fedorov O, Niesen FH, Guo K, Papagrigoriou E, Amos AL, Cho S, Turk BE, Ghosh G, Knapp S. Structure. 2009 Mar 11. PMID: 19278650.", + "Structural insights into the inhibited states of the Mer receptor tyrosine kinase. Huang X, Finerty P Jr, Walker JR, Butler-Cole C, Vedadi M, Schapira M, Parker SA, Turk BE, Thompson DA, Dhe-Paganon S. J Struct Biol. 2009 Feb; 2008 Nov 5. PMID: 19028587.", + "Mixture-based peptide libraries for identifying protease cleavage motifs. Turk BE. Methods Mol Biol. 2009. PMID: 19377969.", + "Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. Filippakopoulos P, Kofler M, Hantschel O, Gish GD, Grebien F, Salah E, Neudecker P, Kay LE, Turk BE, Superti-Furga G, Pawson T, Knapp S. Cell. 2008 Sep 5. PMID: 18775312.", + "Linear motif atlas for phosphorylation-dependent signaling. Miller ML, Jensen LJ, Diella F, Jørgensen C, Tinti M, Li L, Hsiung M, Parker SA, Bordeaux J, Sicheritz-Ponten T, Olhovsky M, Pasculescu A, Alexander J, Knapp S, Blom N, Bork P, Li S, Cesareni G, Pawson T, Turk BE, Yaffe MB, Brunak S, Linding R. Sci Signal. 2008 Sep 2; 2008 Sep 2. PMID: 18765831.", + "Substrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifs. Sheridan DL, Kong Y, Parker SA, Dalby KN, Turk BE. J Biol Chem. 2008 Jul 11; 2008 May 15. PMID: 18482985.", + "A versatile strategy to define the phosphorylation preferences of plant protein kinases and screen for putative substrates. Vlad F, Turk BE, Peynot P, Leung J, Merlot S. Plant J. 2008 Jul. PMID: 18363786.", + "AMPK phosphorylation of raptor mediates a metabolic checkpoint. Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. Mol Cell. 2008 Apr 25. PMID: 18439900.", + "Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. Pike AC, Rellos P, Niesen FH, Turnbull A, Oliver AW, Parker SA, Turk BE, Pearl LH, Knapp S. EMBO J. 2008 Feb 20; 2008 Jan 31. PMID: 18239682.", + "Sterling Hall of Medicine 333 Cedar Street New Haven, CT 06520", + "4 Events you could attend in November 2025 Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Vaccarino Lab", + "lab_url": "https://medicine.yale.edu/lab/vaccarino/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "VAMOS Lab", + "lab_url": "https://medicine.yale.edu/lab/vamos/", + "research_bio": "INFORMATION FOR The Vascular Medicine OutcomeS (VAMOS) research program’s mission is to serve communities by improving vascular health outcomes. Multidisciplinary and global in its reach, it wants to build a culture of collaboration and diversity in vascular outcomes research. Important pillars of our program are training the next generation of global leaders in vascular outcomes research, and to lead innovations in patient-centered care supported by the insights generated through vascular outcomes research. Amongst its many partnerships, our research is being conducted by engaging patients and their families as research partners, such that their preferences for care and outcomes that matter to them are reflected in the work we do. We are building a community of patients, clinicians, scholars, trainees, and many others dedicated to the empowerment of patients, understanding quality of care, and leading innovations in vascular care.", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Vasiliou Laboratory (V-Lab)", + "lab_url": "https://medicine.yale.edu/lab/vasiliou/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Vasquez Lab", + "lab_url": "https://medicine.yale.edu/lab/vasquez/", + "research_bio": "INFORMATION FOR Copy Link Our translational and multidisciplinary laboratory is at the intersection of DNA repair, tumor metabolism, and cancer immunology. We strive to discover treatment approaches that exploit DNA repair and metabolic pathways to selectively target solid tumors while also sensitizing them to immunotherapy. The goal of our laboratory is to uncover novel treatments for hard-to-treat cancers. Our approach is to understand how defects in a tumor's ability to repair its DNA and maintain its energy supply result in vulnerabilities that can be exploited for therapeutic gain. In addition, our lab seeks to better understand how targeting DNA repair and metabolic pathways impacts the immune response against tumors, making them more sensitive to immunotherapies. Meet the members of Vasquez Lab Copy Link", + "publications_page": "https://medicine.yale.edu/lab/vasquez/publications/", + "publications": [ + "Yale School of Medicine /", + "Pediatrics /", + "Research & Projects", + "Team", + "Publications", + "Contact Us", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research & Projects", + "Team", + "Publications", + "Contact Us", + "", + "", + "", + "", + "", + "", + "NAPRT Silencing in FH-Deficient Renal Cell Carcinoma Confers Therapeutic Vulnerabilities via NAD+ Depletion Noronha K, Lucas K, Paradkar S , Edmonds J, Friedman S, Murray M, Liu S, Sajed D, Sachs C, Spurrier J, Raponi M, Liang J, Zeng H, Sundaram R, Shuch B , Vasquez J , Bindra R . NAPRT Silencing in FH-Deficient Renal Cell Carcinoma Confers Therapeutic Vulnerabilities via NAD+ Depletion . Molecular Cancer Research 2024, 22: of1-of16. PMID: 38949523 , PMCID: PMC11445649 , DOI: 10.1158/1541-7786.mcr-23-1003 . Peer-Reviewed Original Research Citations Altmetric Concepts Renal cell carcinoma Cellular processes Cell carcinoma Fumarate hydratase Impact diverse cellular processes Alpha-ketoglutarate-dependent dioxygenases Diverse cellular processes Accumulation of fumarate Preiss-Handler pathway Multiple cellular processes Loss of function mutations Associated with silencing Nicotinamide phosphoribosyl transferase inhibitor Pattern of hypermethylation FH-deficient renal cell carcinomas Synergistic tumor cell killing Aggressive subtype of renal cell carcinoma Loss of FH Subtype of renal cell carcinoma DNA repair processes Poly(ADP)-ribose polymerase inhibitors CpG islands Tumor cell killing Preiss-Handler Cell line models", + "Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor Malik S, Pradeep S, Kumar V, Xiao Y, Deng Y, Fan R, Vasquez J , Singh V, Bahal R. Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor . Cell Reports Medicine 2024, 5: 101354. PMID: 38183981 , PMCID: PMC10829792 , DOI: 10.1016/j.xcrm.2023.101354 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords DNA Humans Neoplasms Nucleic Acids Peptide Nucleic Acids RNA Concepts Target genomic DNA Genomic DNA Sequencing of genomic DNA Genomic DNA level Inhibit c-myc transcription C-myc transcription Genomic DNA targets Target oncogenes Multiple cell lines C-Myc inhibitor Cancer therapy Histone deacetylase inhibitors RNA targets DNA targets Patient-derived xenografts Pre-clinical models DNA Deacetylase inhibitors Cell lines Oncogene Inhibiting oncogenes DNA levels Antitumor efficacy Precision medicine Chemotherapeutic drugs", + "Rhabdomyosarcoma with isolated lung metastases: A report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group Vasquez J , Luo L, Hiniker S, Rhee D, Dasgupta R, Chen S, Weigel B, Xue W, Venkatramani R, Arndt C. Rhabdomyosarcoma with isolated lung metastases: A report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group . Pediatric Blood & Cancer 2023, 70: e30293. PMID: 36916768 , PMCID: PMC10424503 , DOI: 10.1002/pbc.30293 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Child Humans Infant Lung Neoplasms Progression-Free Survival Rhabdomyosarcoma Rhabdomyosarcoma, Embryonal Soft Tissue Neoplasms Concepts Event-free survival Metastatic disease Years of age Overall survival Oncology Group Lung metastases Exact test Soft Tissue Sarcoma Committee Superior event-free survival Better survival outcomes Kaplan-Meier method Children's Oncology Group Risk stratification algorithm Log-rank test Outcome of children Fisher's exact test N0 disease Aggressive treatment Metastatic rhabdomyosarcoma Extrapulmonary sites Metastatic sites Extremity tumors Survival outcomes Embryonal histology COG protocols", + "Antigen-independent tumor targeting by CBX-12 (alphalex™–exatecan) induces long-term antitumor immunity Gayle S, Paradis T, Jones K, Vasquez J , Paralkar V. Antigen-independent tumor targeting by CBX-12 (alphalex™–exatecan) induces long-term antitumor immunity . Immunotherapy 2022, 14: 1467-1480. PMID: 36597724 , DOI: 10.2217/imt-2022-0121 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Camptothecin Cell Line, Tumor Immunity Immunotherapy Neoplasms Tumor Microenvironment Concepts Long-term antitumor immunity Antitumor immunity Immune recognition of tumor cells Inducer of immunogenic cell death Recognition of tumor cells Anti-PD-1 Immunogenic cell death Delayed tumor growth Expression of MHC-1 Immunotherapy combinations PH-sensitive peptides Complete response CT26 model PD-L1 Tumor cells Tumor targeting Tumor growth Cured animals Clinical trials ELISA assay Immunotherapy MHC-1 Cell death Functional assays Immunity", + "The Role of PARP Inhibitors in Patients with Primary Malignant Central Nervous System Tumors Gueble SE , Vasquez JC , Bindra RS . The Role of PARP Inhibitors in Patients with Primary Malignant Central Nervous System Tumors . Current Treatment Options In Oncology 2022, 23: 1566-1589. PMID: 36242713 , PMCID: PMC12184665 , DOI: 10.1007/s11864-022-01024-5 . Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements Citations MeSH Keywords and Concepts MeSH Keywords Alkylating Agents Biomarkers Central Nervous System Neoplasms Female Humans Immune Checkpoint Inhibitors Ovarian Neoplasms Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases Concepts Homologous recombination deficiency Primary CNS tumors CNS tumors Clinical trials PARP inhibitors Preclinical evidence Primary malignant central nervous system tumor Malignant central nervous system tumors Central nervous system tumors Immune checkpoint inhibitors Standard treatment modality Initial clinical trials Early phase trials Nervous system tumors Central nervous tumors Extracranial cancer Checkpoint inhibitors Devastating malignancy Standard therapy Ongoing trials Combination therapy Treatment options Treatment modalities System tumors Phase trials", + "Metastatic and multiply relapsed SDH‐deficient GIST and paraganglioma displays clinical response to combined poly ADP‐ribose polymerase inhibition and temozolomide Singh C , Bindra RS , Glazer PM , Vasquez JC , Pashankar F . Metastatic and multiply relapsed SDH‐deficient GIST and paraganglioma displays clinical response to combined poly ADP‐ribose polymerase inhibition and temozolomide . Pediatric Blood & Cancer 2022, 70: e30020. PMID: 36151992 , DOI: 10.1002/pbc.30020 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords Adenosine Diphosphate Ribose DNA Repair Gastrointestinal Stromal Tumors Humans Paraganglioma Poly(ADP-ribose) Polymerases Temozolomide", + "Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy Ueno D, Vasquez JC , Sule A, Liang J, van Doorn J, Sundaram R, Friedman S, Caliliw R, Ohtake S, Bao X, Li J, Ye H, Boyd K, Huang RR, Dodson J, Boutros P, Bindra RS , Shuch B . Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy . Oncotarget 2022, 13: 1054-1067. PMID: 36128328 , PMCID: PMC9477221 , DOI: 10.18632/oncotarget.28273 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Adenosine Diphosphate Ribose Animals Carcinoma, Renal Cell Citric Acid Cycle Dioxygenases DNA Fumarate Hydratase Fumarates Humans Jumonji Domain-Containing Histone Demethylases Kidney Neoplasms Lysine Mice Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerase Inhibitors Succinate Dehydrogenase Succinates Temozolomide Concepts Renal cell carcinoma Poly ADP-ribose polymerase inhibitors ADP-ribose polymerase inhibitors Cell carcinoma SDH-deficient renal cell carcinoma Polymerase inhibitors Low-dose temozolomide Aggressive renal cell carcinoma Hereditary cancer syndromes Novel therapeutic strategies Deficient murine model Standard dosing TMZ results Murine model Therapeutic strategies Combination treatment Cancer syndromes Tumor growth Homologous recombination DNA repair pathway Accumulation of fumarate HR deficiency PARP inhibition Temozolomide Chemotherapy Carcinoma", + "TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor. Jo U, Murai Y, Agama KK, Sun Y, Saha LK, Yang X, Arakawa Y, Gayle S, Jones K, Paralkar V, Sundaram RK, Van Doorn J, Vasquez JC , Bindra RS , Choi WS, Pommier Y. TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor. Molecular Cancer Therapeutics 2022, 21: 1090-1102. PMID: 35439320 , PMCID: PMC9256811 , DOI: 10.1158/1535-7163.mct-21-1000 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Animals Ataxia Telangiectasia Mutated Proteins Camptothecin DNA DNA Topoisomerases, Type I Humans Mice Neoplasms Nuclear Proteins Protein Kinase Inhibitors Topoisomerase I Inhibitors Concepts ATR inhibitors Top1 inhibitors Homologous recombination deficiency Novel molecular interaction Apoptotic cell death Cancer cells Top1 cleavage complexes Ataxia telangiectasia Cleavage complexes Cell death DNA damage Higher DNA damage Molecular interactions DNA base Kinase inhibitors I inhibitor Molecular pharmacology Mouse xenografts TOP1 Recombination deficiency Topoisomerase I inhibitor Inhibitors Tumor growth Rad3 Predictive biomarkers", + "Targeting IDH1/2 mutant cancers with combinations of ATR and PARP inhibitors Sule A, Van Doorn J, Sundaram RK, Ganesa S, Vasquez JC , Bindra RS . Targeting IDH1/2 mutant cancers with combinations of ATR and PARP inhibitors . NAR Cancer 2021, 3: zcab018. PMID: 34027408 , PMCID: PMC8127964 , DOI: 10.1093/narcan/zcab018 . Peer-Reviewed Original Research Citations Altmetric", + "Risk associated alterations in marrow T cells in pediatric leukemia Bailur JK, McCachren SS, Pendleton K, Vasquez JC , Lim H, Duffy A, Doxie D, Kaushal A, Foster C, DeRyckere D, Castellino S, Kemp ML, Qiu P, Dhodapkar M, Dhodapkar K. Risk associated alterations in marrow T cells in pediatric leukemia . JCI Insight 2020, 5: e140179. PMID: 32692727 , PMCID: PMC7455136 , DOI: 10.1172/jci.insight.140179 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Adolescent Bone Marrow Case-Control Studies Child Child, Preschool Female Gene Expression Profiling Humans Infant Killer Cells, Natural Leukemia, Myeloid, Acute Male Precursor Cell Lymphoblastic Leukemia-Lymphoma Reproducibility of Results Risk Factors Single-Cell Analysis T-Lymphocytes Tumor Microenvironment Concepts Acute lymphoblastic leukemia Naive T cells T cells Disease risk Childhood leukemia Lymphoblastic leukemia Stem-like memory T cells Terminal effector T cells B-cell acute lymphoblastic leukemia Chronic immune activation Cell acute lymphoblastic leukemia Effector T cells Marrow T cells Memory T cells Acute myelogenous leukemia Evidence of dysfunction Stem-like genes Immune signatures NK cells Clinical features Immune environment Immune landscape Immune therapy Immune activation Immune microenvironment", + "Subtype and grade-dependent spatial heterogeneity of T-cell infiltration in pediatric glioma Robinson MH, Vasquez J , Kaushal A, MacDonald TJ, Vega J, Schniederjan M, Dhodapkar K. Subtype and grade-dependent spatial heterogeneity of T-cell infiltration in pediatric glioma . Journal For ImmunoTherapy Of Cancer 2020, 8: e001066. PMID: 32788236 , PMCID: PMC7422651 , DOI: 10.1136/jitc-2020-001066 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Brain Neoplasms Glioma Humans Male Neoplasm Grading T-Lymphocytes Tumor Microenvironment Concepts T cell infiltration High-grade gliomas T-cell density Low-grade tumors T cells Glial tumors Tissue-resident memory T cells Tumor-resident T cells Pediatric gliomas Tumor-infiltrating T cells Memory T cells Cancer-related mortality Pediatric glial tumors Single-cell mass cytometry Expression of SOX2 Stem cell markers Immune control Immune therapy Recurrent tumors Immune cells Immunofluorescence immunohistochemistry Pleomorphic xanthoastrocytoma Brain tumors Immune architecture Adult gliomas", + "Persistent STAG2 mutation despite multimodal therapy in recurrent pediatric glioblastoma Hong CS , Vasquez JC , Kundishora AJ , Elsamadicy AA , Beckta JM, Sule A, Marks AM , Leelatian N, Huttner A , Bindra RS , DiLuna ML , Kahle KT , Erson-Omay EZ. Persistent STAG2 mutation despite multimodal therapy in recurrent pediatric glioblastoma . Npj Genomic Medicine 2020, 5: 23. PMID: 32528726 , PMCID: PMC7264170 , DOI: 10.1038/s41525-020-0130-7 . Peer-Reviewed Original Research Citations Altmetric Concepts Pediatric patients Standard chemoradiation STAG2 mutations Tumor clones Pediatric glioblastoma Gross total resection Multiple surgical resections Time of recurrence High-grade gliomas DNA damage repair defects Whole-exome sequencing Variety of treatments Surgical resection Novel deleterious mutations Standard therapy Total resection Vaccine therapy Clinical evidence Preclinical data Treatment options Multimodal therapy Preclinical studies Clinical setting Therapy Adult counterparts", + "Sinusoidal Obstruction Syndrome During Maintenance Therapy for Acute Lymphoblastic Leukemia With 6-Mercaptopurine and Methotrexate: A Pediatric Case Report. McNerney KO, Vasquez JC , Kent MW , McNamara JM . Sinusoidal Obstruction Syndrome During Maintenance Therapy for Acute Lymphoblastic Leukemia With 6-Mercaptopurine and Methotrexate: A Pediatric Case Report. Journal Of Pediatric Hematology/oncology 2017, 39: e454-e455. PMID: 28085749 , DOI: 10.1097/MPH.0000000000000776 . Peer-Reviewed Original Research", + "SOX2 immunity and tissue resident memory in children and young adults with glioma Vasquez JC , Huttner A , Zhang L, Marks A , Chan A, Baehring JM , Kahle KT , Dhodapkar KM. SOX2 immunity and tissue resident memory in children and young adults with glioma . Journal Of Neuro-Oncology 2017, 134: 41-53. PMID: 28620836 , PMCID: PMC7906294 , DOI: 10.1007/s11060-017-2515-8 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Adolescent Adult Age Factors Antigen-Presenting Cells B7-H1 Antigen Brain Neoplasms Cell Proliferation Child Child, Preschool Cytokines Female Flow Cytometry Glioma Humans Infant Male Myeloid Cells Programmed Cell Death 1 Receptor Receptors, Immunologic RNA, Small Interfering SOXB1 Transcription Factors T-Lymphocytes Transfection Young Adult Concepts Pediatric glial tumors Glial tumors T cells Expression of SOX2 Inhibitory checkpoints CD8/CD4 T cells Tissue-resident memory phenotype Tumor-infiltrating immune cells Tumor-infiltrating T cells Tumor cells Young adults Resident memory phenotype Tissue-resident memory Anti-tumor immunity T cell immunity CD4 T cells Natural killer cells Glial tumor cells New antigenic targets Single-cell mass cytometry High mutation burden Stem cell antigen Glioma initiating cells Immune checkpoints PD-1", + "ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells Boddupalli CS, Nair S , Gray SM, Nowyhed HN, Verma R, Gibson JA , Abraham C , Narayan D , Vasquez J , Hedrick CC, Flavell RA , Dhodapkar KM, Kaech SM , Dhodapkar MV. ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells . Journal Of Clinical Investigation 2016, 126: 3905-3916. PMID: 27617863 , PMCID: PMC5096804 , DOI: 10.1172/jci85329 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Adoptive Transfer Animals ATP-Binding Cassette Transporters Cells, Cultured Humans Immunologic Memory Mice, Inbred C57BL Mice, Inbred NOD Mice, Knockout Mice, SCID Nuclear Receptor Subfamily 4, Group A, Member 1 Organ Specificity Resting Phase, Cell Cycle T-Lymphocytes Transcriptome Concepts Tissue-resident memory T cells Memory T cells T cells TRM cells Cellular therapy Adoptive cellular therapy Immune-deficient mice Potential cellular therapy SP T cells Side population cells Human T cells Putative subsets Adoptive transfer Distinct gene expression profiles Cell mobilization Immune surveillance Quiescent subset Population cells Mice Therapy Quiescent phenotype Distinct subsets Member 1 Nuclear receptors Signature genes", + "Clinical and pharmacodynamic analysis of pomalidomide dosing strategies in myeloma: impact of immune activation and cereblon targets Sehgal K, Das R, Zhang L, Verma R, Deng Y , Kocoglu M, Vasquez J , Koduru S, Ren Y, Wang M, Couto S, Breider M, Hansel D, Seropian S , Cooper D, Thakurta A, Yao X, Dhodapkar KM, Dhodapkar MV. Clinical and pharmacodynamic analysis of pomalidomide dosing strategies in myeloma: impact of immune activation and cereblon targets . Blood 2015, 125: 4042-4051. PMID: 25869284 , PMCID: PMC4481593 , DOI: 10.1182/blood-2014-11-611426 . Peer-Reviewed Original Research Citations Altmetric MeSH Keywords and Concepts MeSH Keywords Angiogenesis Inhibitors Female Humans Immunohistochemistry Kaplan-Meier Estimate Killer Cells, Natural Male Middle Aged Multiple Myeloma Neoplasm Recurrence, Local T-Lymphocytes Thalidomide Tumor Microenvironment Concepts Immune activation Antitumor effects NK cells T cells More frequent adverse events Clinical antitumor effects Frequent adverse events Natural killer cells Intermittent dosing strategy Direct antitumor effects Expression of cytokines T cell activation Greater tumor reduction Pomalidomide/ Coinhibitory receptors Adverse events Clinical response Overall survival Killer cells Pharmacodynamic effects Immunomodulatory effects Multiple myeloma Tumor reduction Intermittent dosing Pharmacodynamic analysis", + "Beliefs and barriers to medication use in parents of Latino children with asthma. McQuaid EL, Vasquez J , Canino G, Fritz GK, Ortega AN, Colon A, Klein RB, Kopel SJ, Koinis-Mitchell D, Esteban CA, Seifer R. Beliefs and barriers to medication use in parents of Latino children with asthma. Pediatric Pulmonology 2009, 44: 892-8. PMID: 19672958 , PMCID: PMC3266229 , DOI: 10.1002/ppul.21074 . Peer-Reviewed Original Research", + "Ethnic differences in somatic symptom reporting in children with asthma and their parents. Vasquez JC , Fritz GK, Kopel SJ, Seifer R, McQuaid EL, Canino G. Ethnic differences in somatic symptom reporting in children with asthma and their parents. Journal Of The American Academy Of Child And Adolescent Psychiatry 2009, 48: 855-863. PMID: 19564802 , PMCID: PMC3278967 , DOI: 10.1097/CHI.0b013e3181a81333 . Peer-Reviewed Original Research", + "", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Venkatesh Lab", + "lab_url": "https://medicine.yale.edu/lab/venkatesh/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/venkatesh/publications/", + "publications": [ + "Yale School of Medicine /", + "Emergency Medicine /", + "Training Opportunities", + "News", + "Ongoing Research Projects and Initiatives NIH HEAL Initiative", + "NIH HEAL Initiative", + "Lab Members", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Training Opportunities", + "Ongoing Research Projects and Initiatives", + "Lab Members", + "Publications", + "News", + "", + "", + "", + "", + "", + "", + "Fast for Real or Just a Feel? Reassessing Hallway Treatment Spaces and Their Impact on Emergency Department Operations. Dilip M, Su H, Meng L, Tarabar A, Sevilla M, Liebhardt B, Parwani V, Pinker E, Venkatesh AK, Sangal RB. J Am Coll Emerg Physicians Open. 2025 Dec; 2025 Sep 30. PMID: 41081281.", + "A Model for Developing Subspecialty Clinical Practice Guidelines: The Geriatric Emergency Department Guidelines 2.0. Gunaga S, Carpenter CR, Kennedy M, Southerland LT, Lo AX, Lee S, Swan K, Mowbray F, Skains RM, Hogan TM, Casey MF, Ouchi K, George NR, de Wit K, Gettel CJ, Selman K, Ragsdale LC, Chary AN, van Oppen JD, Arendts G, Maddow CL, Hunold KM, Tyler KR, Khoujah D, Hwang U, Liu S. J Am Coll Emerg Physicians Open. 2025 Dec; 2025 Sep 16. PMID: 41019914.", + "Financial Compensation of Academic Emergency Medicine Physicians in the United States. Topping CEW, Venkatesh AK, Agrawal P, Raukar NP, Molina MF, Blomkalns AL, Diercks DB, Gettel CJ. Acad Emerg Med. 2025 Nov 17; 2025 Nov 17. PMID: 41249867.", + "Beyond Right and Wrong: The Diagnostic Calibration Matrix and Decision Latitude as a Tiered Framework for Evaluating Diagnostic Reasoning. Pavuluri SK, Sangal RB, Taylor RA, Iscoe M, Venkatesh AK, Sather JE. Acad Emerg Med. 2025 Nov 12; 2025 Nov 12. PMID: 41225307.", + "Evaluating a Disease-Specific Look-Back Trigger Methodology vs. Traditional Screening for Diagnostic Errors in the Emergency Department. Pavuluri SK, Sangal RB, Rothenberg C, Venkatesh A, Taylor RA, Sather J. Jt Comm J Qual Patient Saf. 2025 Oct 17; 2025 Oct 17. PMID: 41238461.", + "Visit Characteristics of Emergency Departments Caring for Persons Living With Dementia: A Nationally Representative Sample. Galske J, Martindale J, Bynum J, Venkatesh A, Berg K, Gettel CJ. Acad Emerg Med. 2025 Oct 14; 2025 Oct 14. PMID: 41085468.", + "Managing Clinical Uncertainty: Formalizing Management Reasoning in Emergency Care Delivery. Haimovich AD, Janke AT, Kocher KE, Mangus CW, Parsons AS, McCoy L, Taylor RA, Rodman A, Pusic M. Ann Emerg Med. 2025 Oct 10; 2025 Oct 10. PMID: 41071138.", + "Trends in Nonresearch Industry Payments to Emergency Physicians Between 2016 and 2023. Owda D, Radu C, Ross JS, Rothenberg C, Venkatesh AK. Ann Emerg Med. 2025 Oct 9; 2025 Oct 9. PMID: 41071135.", + "Treatment of Opioid Use Disorder Across a National Emergency Department Practice Improvement Network. Weiner SG, Venkatesh AK, Sharma PB, Rothenberg C, Shahid S, Sambell M, Goyal P, Hawk KF. Ann Emerg Med. 2025 Oct 9; 2025 Oct 9. PMID: 41071133.", + "Trends in and Predictors of Physician Attrition From Clinical Practice Across Specialties : A Nationwide, Longitudinal Analysis. Rotenstein LS, He Z, Dziura J, Tsugawa Y, Venkatesh AK, Melnick ER, Gettel CJ. Ann Intern Med. 2025 Oct 7; 2025 Oct 7. PMID: 41052447.", + "Effect of a Clinical Decision Support Tool for Identifying Patients Benefiting from End-of-Life Discussions on Emergency Department Clinician Behavior. Dilip M, Rothenberg C, Van Tonder R, Jubanyik K, Venkatesh AK, Rhodes D, Sangal RB, Kim N. Appl Clin Inform. 2025 Oct; 2025 Nov 14. PMID: 41238198.", + "Stranded in the emergency department: an analysis of boarding trends in older adults in the United States. Sifnugel N, Jeffery MM, Grogan EFL, Sangal RB, Carr BM, Cruz DS, Dresden S, Gettel CJ, Iscoe M, Skains RM, Venkatesh A, Hwang U. Health Aff Sch. 2025 Oct; 2025 Sep 29. PMID: 41143086.", + "Trends in Emergency Care Provided by Non-Physician Providers and Physicians: 2009-2021. Ghaith S, Gettel C, McElhinny M, Mullan AF, Jeffery MM, Lindor RA. Acad Emerg Med. 2025 Oct; 2025 Aug 8. PMID: 40781634.", + "Development and Pilot Testing of an Artificial Intelligence and Care Coach Intervention for Cognitively Impaired Older Adults. Gettel CJ, Dorai C, Galske J, Chera T, Stern E, Keefe K, DeFrancesco E, Seetharam S, Nagaraj S, Raveendranathan V, Gil H. J Am Geriatr Soc. 2025 Oct; 2025 Aug 2. PMID: 40751486.", + "Low vacuum (3 mL) rapid serum tubes offer better protection from hemolysis than plasma separator tubes collected in the emergency department. Shang E, Takasugi T, Prellwitz P, Figueroa Villalba C, Sangal RB, Venkatesh AK, Maciejak L, Oberle E, El-Khoury JM. Clin Biochem. 2025 Oct; 2025 Jul 26. PMID: 40721040.", + "Pathway for a Diverse and Sustainable Emergency Medicine Clinician-Scientist Workforce: Recommendations From the 2024 SAEM Consensus Conference. Neumar RW, Boatright D, McMillian M, Corbin T, Norman MS, Vogel J, Callaway CW, Holden L, Pierce AE, Regan L, Richardson LD, Ryus CR, Adeoye O, Blomkalns A, Gerardo CJ, Kuppermann N, D'Onofrio G. Acad Emerg Med. 2025 Oct; 2025 Jul 4. PMID: 40613765.", + "The Authors Respond to Reader Comment Regarding: \"Automated Computation of the HEART Score with the GPT-4 Large Language Model\". Taylor RA, Wright DS. Am J Emerg Med. 2025 Oct; 2025 May 20. PMID: 40410037.", + "Florida's \"Live Healthy\" Legislation: Implications for Financing \"Nonemergent\" Emergency Care. Lee TA, Wegman M, Venkatesh AK, Koski-Vacirca R, Panthagani K, Rothenberg C, Janke A, Hwang U, Gettel CJ. Med Care. 2025 Sep 30; 2025 Sep 30. PMID: 41026886.", + "Ambulatory Care Follow-Up and Fragmentation After Emergency Department Visits Among Older Adults. Gettel CJ, Song Y, Lee TA, Rothenberg C, Kitchen C, Liang Y, Bynum JPW, Hastings SN, Venkatesh AK. J Appl Gerontol. 2025 Sep 25; 2025 Sep 25. PMID: 40995890.", + "Development of a Unified Geriatric Emergency Department Database, 2022. Herscovici DM, Boggs KM, Swanton M, Espinola JA, Samuels-Kalow ME, Sullivan AF, Gettel CJ, Chary AN, Kennedy M, Camargo CA Jr. Ann Emerg Med. 2025 Sep 19; 2025 Sep 19. PMID: 40974365.", + "Association Between Usual Clinician Presence and Emergency Department Revisitation. Agboh DS, Venkatesh AK, Liang Y, Salah W, Rothenberg C, Ross JS, Ganguli I, Gettel CJ. J Am Geriatr Soc. 2025 Sep 12; 2025 Sep 12. PMID: 40938262.", + "An adaptive simulation intervention decreases emergency physician physiologic stress while caring for patients during COVID-19: A randomized clinical trial. Evans LV, Bonz JW, Buck S, Gerwin JN, Bonner S, Ikejiani S, Moylan T, Joseph M, de Oliveira Almeida G, Ray JM, Dziura JD, Venkatesh AK, Wong AH. PLoS One. 2025; 2025 Sep 3. PMID: 40901855.", + "Pediatric Bed Capacity, Bed Strain, and Load Imbalance During the 2022 Respiratory Viral Season. Ijaz N, Radu C, Rothenberg C, Janke AT, Venkatesh AK. JAMA Netw Open. 2025 Sep 2; 2025 Sep 2. PMID: 41004148.", + "State-Level Variation in and Barriers to Medicaid Abortion Coverage. Jiang JW, Ho SJ, Suttiratana SC, Topping CEW, Venkatesh AK, Owda R, Smith PJ, Owda D, Khidir H. JAMA Netw Open. 2025 Sep 2; 2025 Sep 2. PMID: 40920379.", + "Variation in point-of-care ultrasound privileges in academic emergency departments. Boivin Z, Venkatesh AK, Moore CL. Acad Emerg Med. 2025 Sep; 2025 May 23. PMID: 40407801.", + "Emergency Department Utilization Among Co-Residing Family Caregivers of Persons Living With Dementia. Cha PC, Rothenberg C, Chary AN, Seidenfeld J, Hwang U, Fried T, Monin JK, Venkatesh AK, Gettel CJ. J Am Geriatr Soc. 2025 Sep; 2025 May 10. PMID: 40347207.", + "Short-Stay Hospitalizations and Hospital Capacity Constraints. Janke AT, Sun WW, Gibson C, Rothenberg C, Lin S, Tuffuor K, Dilip M, Buchla A, Kocher KE, Sangal RB, Venkatesh AK. Ann Emerg Med. 2025 Sep; 2025 Apr 12. PMID: 40220007.", + "Load leveling as a strategy to enhance emergency department throughput. Dilip M, Su H, Zhang W, Meng L, Tuffuor K, Pham L, Fogerty R, Venkatesh AK, Pinker E, Sangal RB. Am J Emerg Med. 2025 Aug 27; 2025 Aug 27. PMID: 40907274.", + "Emergency Medicine Residency Match Trends and Evolving Applicant Composition, 2015-2025. Voskanov M, Johnson C, Campbell R, Homme J, Gettel C, Hunter D. Ann Emerg Med. 2025 Aug 23; 2025 Aug 23. PMID: 40848026.", + "Limited Added Value of Pelvic Ultrasound After Negative CT Abdomen Pelvis for Emergent Gynecologic Pathology. Hossin T, Sangal RB, Cavallo J, Huynh TQ, Taylor RA, Venkatesh AK. J Am Coll Radiol. 2025 Aug 21; 2025 Aug 21. PMID: 40848823.", + "Emergency Medical Services Time on Scene and Non-Transport: Role of Communication Barriers. Kurkurina E, Rothenberg C, Couturier K, Breyre A, Yang D, Nelson AR, Cordone A, Venkatesh AK, Gettel CJ. West J Emerg Med. 2025 Aug 20; 2025 Aug 20. PMID: 41193020.", + "Peripheral Vasopressor Use in Early Sepsis-Induced Hypotension. Munroe ES, Co IN, Douglas I, Hyzy R, Khan A, Nelson K, Park PK, Peltan ID, Rice TW, Seelye S, Self WH, Shapiro NI, Prescott HC. JAMA Netw Open. 2025 Aug 1; 2025 Aug 1. PMID: 40864467.", + "Work Impairment and Financial Outcomes Among Adults With vs Without Long COVID. Gottlieb M, Chen J, Yu H, Santangelo M, Spatz ES, Gentile NL, Geyer RE, Malicki C, Gatling K, O'Laughlin KN, Stephens KA, Elmore JG, Wisk LE, L'Hommedieu M, Rodriguez R, Montoy JCC, Wang RC, Rising KL, Kean E, Dyal JW, Hill MJ, Venkatesh AK, Weinstein RA. JAMA Netw Open. 2025 Aug 1; 2025 Aug 1. PMID: 40794410.", + "Variability in Long COVID Definitions and Validation of Published Prevalence Rates. Wisk LE, L'Hommedieu M, Diaz Roldan K, Ebna Mannan I, Spatz ES, Weinstein RA, Venkatesh AK, Gottlieb M, Huebinger R, Rising KL, Montoy JCC, Stephens KA, Rodriguez RM, Hill MJ, O'Laughlin KN, Gentile NL, Idris AH, Li SX, Santangelo M, Kean ER, McDonald SA, Gatling K, Elmore JG. JAMA Netw Open. 2025 Aug 1; 2025 Aug 1. PMID: 40794409.", + "Development of a Quality Measure to Improve HIV and Syphilis Screening in the Emergency Department: A Modified Delphi Approach. Rehman T, Bennett C, Duber HC, Lyons MS, Phelan MP, Solnick RE, Stanford KA, Weathers E, Venkatesh AK, Lin MP. J Am Coll Emerg Physicians Open. 2025 Aug; 2025 Jul 3. PMID: 40689401.", + "Emergency Department Implementation of a Multimodal Electronic Health Record-Integrated Clinical Intervention for High-Sensitivity Troponin Testing Increases Diagnostic Efficiency. Sangal RB, Iscoe M, Rothenberg C, Possick S, Taylor RA, Safdar B, Desai NR, Rhodes DJ, Venkatesh AK. J Am Coll Emerg Physicians Open. 2025 Aug; 2025 Jun 19. PMID: 40606317.", + "Emergency Physician Employer Market Share and Concentration by Ownership Type. Cai AG, Jarou ZJ, Janke AT, Gettel CJ, Rothenberg C, Adelman LC, Simpson M, Fisher J, Venkatesh AK. Ann Emerg Med. 2025 Jul 31; 2025 Jul 31. PMID: 40758080.", + "Development and Validation of an Administrative Claims Measure of Emergency Medical Services (EMS) Triage Quality for Mobile Integrated Health Interventions. Voll N, Gettel C, Li SX, Qin L, Li Y, Attanasio S, Epshtein I, Nichols M, Lilly A, Quinton J, Bernheim S, Stiles H, Murugiah K, Mann NC, Venkatesh A. Prehosp Emerg Care. 2025 Jul 31; 2025 Jul 31. PMID: 40689629.", + "Emergency department visits among rural and urban older adults: disparities in ambulatory and emergency care sensitive conditions. Gettel CJ, Kitchen C, Rothenberg C, Song Y, Koski-Vacirca R, Schaffer K, Janke AT, Mohr NM, Greenwood-Ericksen M, Venkatesh AK. BMC Health Serv Res. 2025 Jul 24; 2025 Jul 24. PMID: 40707938.", + "Effects of long COVID on healthcare utilization. Gottlieb M, Spatz ES, Yu H, Ebna Mannan I, Santangelo M, Malicki C, Gentile NL, Geyer RE, Charlton A, Dyal JW, Elmore JG, Gatling K, Hill MJ, Montoy JCC, O'Laughlin KN, Rising KL, Saydah S, Stephens KA, Wang RC, Wisk LE, Venkatesh AK, Weinstein RA. PLoS One. 2025; 2025 Jul 23. PMID: 40700379.", + "Participant engagement in a national longitudinal study of COVID-19: Insights from the INSPIRE study. Ma KPK, Stober T, Gottlieb M, Geyer RE, Rising K, Saydah S, Santangelo M, Gatling K, Grau D, Wang RC, Montoy JC, Idris A, MacDonald S, Hill MJ, Huebinger R, Prado MG, Gentile NL, Spatz E, Maliki C, Dorney J, Elmore JG, L'Hommedieu M, Weinstein RA, Venkatesh AK, Stephens KA. PLoS One. 2025; 2025 Jul 22. PMID: 40694553.", + "Emergency Medicine at the Frontline of Climate Change: The Role of Geographic Information Systems. Surapaneni T, Patrikakou A, Faka A, Grant L, Ulrich A, Tsiftsis D, Reid E. West J Emerg Med. 2025 Jul 18; 2025 Jul 18. PMID: 40794994.", + "Physicians in Greece's Emergency Departments: Attitudes, Readiness, and Need for Formal Training. Aly S, Babales D, Kouliou O, Ulrich A, Reid E, Tsiftsis D. West J Emerg Med. 2025 Jul 9; 2025 Jul 9. PMID: 40795001.", + "Automated computation of the HEART score with the GPT-4 large language model. Wright DS, Socrates V, Huang T, Safranek CW, Sangal RB, Dilip M, Boivin Z, Srica N, Wright CX, Feher A, Miller EJ, Chartash D, Taylor RA. Am J Emerg Med. 2025 Jul; 2025 Apr 1. PMID: 40184662.", + "Patient Volume Requirements: Evaluation of the 2025 ACGME Proposal for Emergency Medicine Residency Programs. Topping CEW, Rothenberg C, Gettel CJ, Sangal RB, Goldflam K, Ulrich A, Agrawal P, Courtney DM, Venkatesh AK. AEM Educ Train. 2025 Jun; 2025 Jun 25. PMID: 40574930.", + "A systematic review of interventions for persons living with dementia: The Geriatric ED Guidelines 2.0. Lee S, Suh M, Ragsdale L, Seidenfeld J, van Oppen JD, Lapointe-Shaw L, Diniz Hooper C, Jaramillo J, Wescott AB, Lo AX, Hirata K, Kennedy M, Comasco LC, Carpenter CR, Hogan TM, Liu SW. Acad Emerg Med. 2025 Jun 19; 2025 Jun 19. PMID: 40534401.", + "Case Report: A health system's experience using clinical decision support to promote note sharing after the 21st Century Cures Act. Iscoe M, Venkatesh AK, Powers EM, Kashyap N, Hsiao AL, Millard H, Sangal RB. JAMIA Open. 2025 Jun; 2025 Jun 12. PMID: 40510806.", + "Association of SARS-CoV-2 With Health-related Quality of Life 1 Year After Illness Using Latent Transition Analysis. Wisk LE, Gottlieb M, Chen P, Yu H, O'Laughlin KN, Stephens KA, Nichol G, Montoy JCC, Rodriguez RM, Santangelo M, Gatling K, Spatz ES, Venkatesh AK, Rising KL, Hill MJ, Huebinger R, Idris AH, Willis M, Kean E, McDonald SA, Elmore JG, Weinstein RA. Open Forum Infect Dis. 2025 Jun; 2025 Jun 10. PMID: 40496983.", + "Detection of emergency department patients at risk of dementia through artificial intelligence. Cohen I, Taylor RA, Xue H, Faustino IV, Festa N, Brandt C, Gao E, Han L, Khasnavis S, Lai JM, Mecca AP, Sapre AV, Young J, Zanchelli M, Hwang U. Alzheimers Dement. 2025 Jun. PMID: 40457744.", + "Clinical Practice Patterns of the Emergency Physician Workforce Before and After Attrition. Agboh DS, Venkatesh AK, Rothenberg C, Pines JM, Bellolio F, Jeffery MM, Courtney DM, Gettel CJ. Ann Emerg Med. 2025 Jun; 2025 Mar 4. PMID: 40047774.", + "Workforce Attrition Among Emergency Medicine Non-Physician Practitioners. Gettel CJ, Ghosh R, Rothenberg C, Balga T, Chekijian S, Colella S, Agrawal P, Holmes M, Venkatesh AK. Ann Emerg Med. 2025 Jun; 2025 Jan 17. PMID: 39818677.", + "Assessment of health conditions from patient electronic health record portals vs self-reported questionnaires: an analysis of the INSPIRE study. Khera R, Sawano M, Warner F, Coppi A, Pedroso AF, Spatz ES, Yu H, Gottlieb M, Saydah S, Stephens KA, Rising KL, Elmore JG, Hill MJ, Idris AH, Montoy JCC, O'Laughlin KN, Weinstein RA, Venkatesh A. J Am Med Inform Assoc. 2025 May 1. PMID: 40036551.", + "Reply to \"Reconsidering the validity of the PROM-OTED tool in geriatric emergency care transitions\". Gettel CJ, Venkatesh AK, Uzamere I, Galske J, Chera T, White MA, Hwang U. Acad Emerg Med. 2025 Apr 26; 2025 Apr 26. PMID: 40285510.", + "Identifying Deprescribing Opportunities With Large Language Models in Older Adults: Retrospective Cohort Study. Socrates V, Wright DS, Huang T, Fereydooni S, Dien C, Chi L, Albano J, Patterson B, Sasidhar Kanaparthy N, Wright CX, Loza A, Chartash D, Iscoe M, Taylor RA. JMIR Aging. 2025 Apr 11; 2025 Apr 11. PMID: 40215480.", + "Emergency Care Access Based on a Proposed CMS National Quality Measure. Sangal RB, Rothenberg C, Taylor RA, Venkatesh AK. JAMA Health Forum. 2025 Apr 4; 2025 Apr 4. PMID: 40215073.", + "Detection and differentiation of undiagnosed dementia in the emergency department: A pilot referral pathway. Gettel C, Galske J, Araujo K, Dresden S, Dussetschleger J, Iannone L, Lai J, Martin P, Mignosa B, Muschong K, Safdar B, Weintraub S, Hwang U. Alzheimers Dement. 2025 Apr. PMID: 40257011.", + "Differences in Long COVID severity by duration of illness, symptom evolution, and vaccination: a longitudinal cohort study from the INSPIRE group. Gottlieb M, Yu H, Chen J, Spatz ES, Gentile NL, Geyer RE, Santangelo M, Malicki C, Gatling K, Saydah S, O'Laughlin KN, Stephens KA, Elmore JG, Wisk LE, L'Hommedieu M, Rodriguez RM, Montoy JCC, Wang RC, Rising KL, Kean E, Dyal JW, Hill MJ, Venkatesh AK, Weinstein RA. Lancet Reg Health Am. 2025 Apr; 2025 Feb 14. PMID: 40040820.", + "Who is coming in? Evaluation of physician performance within multi-physician emergency departments. Sangal RB, Teresi R, Dashevsky M, Ulrich A, Tarabar A, Parwani V, Van Tonder R, King M, Venkatesh AK. Am J Emerg Med. 2025 Apr; 2025 Jan 3. PMID: 39793122.", + "Development and validation of the Patient-Reported Outcome Measure-Older adult care Transitions from the Emergency Department (PROM-OTED) tool. Gettel CJ, Venkatesh AK, Uzamere I, Galske J, Chera T, White MA, Hwang U. Acad Emerg Med. 2025 Mar 28; 2025 Mar 28. PMID: 40155783.", + "Using natural language processing to identify emergency department patients with incidental lung nodules requiring follow-up. Moore CL, Socrates V, Hesami M, Denkewicz RP, Cavallo JJ, Venkatesh AK, Taylor RA. Acad Emerg Med. 2025 Mar; 2025 Jan 17. PMID: 39821298.", + "Enhancing Emergency Department Triage Equity With Artificial Intelligence: Outcomes From a Multisite Implementation. Hinson JS, Levin SR, Steinhart BD, Chmura C, Sangal RB, Venkatesh AK, Taylor RA. Ann Emerg Med. 2025 Mar; 2024 Nov 20. PMID: 39570253.", + "Inclusion of Veterans Health Administration hospitals in Centers for Medicare & Medicaid Services Overall Hospital Quality Star Ratings. Bagshaw K, Gettel CJ, Qin L, Lin Z, Suter LG, Rothenberg E, Omotosho P, Duseja R, Krabacher J, Schreiber M, Nakashima T, Myers R, Venkatesh AK. J Hosp Med. 2025 Mar; 2024 Oct 21. PMID: 39434547.", + "Adaptive decision support for addiction treatment to implement initiation of buprenorphine for opioid use disorder in the emergency department: protocol for the ADAPT Multiphase Optimization Strategy trial. Iscoe MS, Diniz Hooper C, Levy DR, Buchanan L, Dziura J, Meeker D, Taylor RA, D'Onofrio G, Oladele C, Sarpong DF, Paek H, Wilson FP, Heagerty PJ, Delgado MK, Hoppe J, Melnick ER. BMJ Open. 2025 Feb 20; 2025 Feb 20. PMID: 39979056.", + "Understanding and Addressing the US Hospital Bed Shortage-Build, Baby, Build. Janke AT, Venkatesh AK. JAMA Netw Open. 2025 Feb 3; 2025 Feb 3. PMID: 39969886.", + "A national digital quality measure to improve emergency department coagulation testing efficiency. Venkatesh AK, Sun WW, Duke J, Shah A, Rothenberg C. Am J Emerg Med. 2025 Feb; 2024 Nov 9. PMID: 39547840.", + "Screening for Cognitive Impairment in the Emergency Department: Agreement between Older Adult Patient- and Informant-Completed Ascertain Dementia 8 Tool. Galske J, Sather A, Chera T, Hwang U, Carpenter CR, Babcock M, Gettel CJ. Dement Geriatr Cogn Disord. 2025; 2024 Nov 29. PMID: 39616991.", + "Quality improvement interventions to reduce coagulation testing overuse in the emergency department. Venkatesh AK, Duke J, Wong S, Shah A, Rothenberg C, Patel A, Sun WW, Shapiro M, Ulrich A, Parwani V. Am J Emerg Med. 2025 Jan; 2024 Oct 20. PMID: 39490322.", + "End-of-life emergency department use and healthcare expenditures among older adults: A nationally representative study. Gettel CJ, Kitchen C, Rothenberg C, Song Y, Hastings SN, Kennedy M, Ouchi K, Haimovich AD, Hwang U, Venkatesh AK. J Am Geriatr Soc. 2025 Jan; 2024 Sep 23. PMID: 39311623.", + "Racial, Ethnic, and Age-Related Disparities in Sedation and Restraint Use for Older Adults in the Emergency Department. Jivalagian P, Gettel CJ, Smith CM, Robinson L, Brinker M, Shah D, Kumar A, Faustino IV, Nath B, Chang-Sing E, Taylor RA, Kennedy M, Hwang U, Wong AH. Am J Geriatr Psychiatry. 2025 Jan; 2024 Jul 8. PMID: 39054237.", + "Why do we need quality measures in emergency medicine? Das S, Miller G, Libby C, Gettel CJ, Rabin E, Lin M. J Am Coll Emerg Physicians Open. 2024 Dec; 2024 Dec 17. PMID: 39697807.", + "\"What Matters\" in the Emergency Department: A Prospective Analysis of Older Adults' Concerns and Desired Outcomes. Chera T, Tinetti M, Travers J, Galske J, Venkatesh AK, Southerland L, Dresden SM, McQuown C, Gettel CJ. Med Care. 2024 Dec 1; 2024 Aug 7. PMID: 39514495.", + "Discharge instruction comprehension by older adults in the emergency department: A systematic review and meta-analysis. Haimovich AD, Mulqueen S, Carreras-Tartak J, Gettel C, Schonberg MA, Hastings SN, Carpenter C, Liu SW, Thomas SH. Acad Emerg Med. 2024 Nov; 2024 Sep 12. PMID: 39264024.", + "Emergency Department Visits Among Patients With Dementia Before and After Diagnosis. Gettel CJ, Song Y, Rothenberg C, Kitchen C, Gilmore-Bykovskyi A, Fried TR, Brody AA, Nothelle S, Wolff JL, Venkatesh AK. JAMA Netw Open. 2024 Oct 1; 2024 Oct 1. PMID: 39401040.", + "Abbreviated MRI in the evaluation of dizziness: report turnaround times and impact on length of stay compared to CT, CTA, and conventional MRI. Tu LH, Tegtmeyer K, de Oliveira Santo ID, Venkatesh AK, Forman HP, Mahajan A, Melnick ER. Emerg Radiol. 2024 Oct; 2024 Jul 22. PMID: 39034381.", + "Daily care hours among caregivers of older emergency department patients with dementia and undiagnosed cognitive impairment. Galske J, Chera T, Hwang U, Monin JK, Venkatesh A, Lam K, Leggett AN, Gettel C. J Am Geriatr Soc. 2024 Oct; 2024 Jul 5. PMID: 38970304.", + "Total and Out-of-Pocket Costs Surrounding Emergency Department Care Among Older Adults Enrolled in Traditional Medicare and Medicare Advantage. Gettel CJ, Salah W, Rothenberg C, Liang Y, Schwartz H, Scott KW, Hwang U, Hastings SN, Venkatesh AK. Ann Emerg Med. 2024 Sep; 2024 Jun 12. PMID: 38864783.", + "Geriatric Emergency Medication Safety Recommendations (GEMS-Rx): Modified Delphi Development of a High-Risk Prescription List for Older Emergency Department Patients. Skains RM, Koehl JL, Aldeen A, Carpenter CR, Gettel CJ, Goldberg EM, Hwang U, Kocher KE, Southerland LT, Goyal P, Berdahl CT, Venkatesh AK, Lin MP. Ann Emerg Med. 2024 Sep; 2024 Mar 12. PMID: 38483427.", + "Reliability of a Measure of Admission Intensity for Emergency Physicians. Janke AT, Oskvarek JJ, Zocchi MS, Cai AG, Litvak O, Pines JM, Venkatesh AK. Ann Emerg Med. 2024 Sep; 2024 Mar 2. PMID: 38430082.", + "Balancing act: the complex role of artificial intelligence in addressing burnout and healthcare workforce dynamics. Pavuluri S, Sangal R, Sather J, Taylor RA. BMJ Health Care Inform. 2024 Aug 24; 2024 Aug 24. PMID: 39181545.", + "Patient-Representing Population's Perceptions of GPT-Generated Versus Standard Emergency Department Discharge Instructions: Randomized Blind Survey Assessment. Huang T, Safranek C, Socrates V, Chartash D, Wright D, Dilip M, Sangal RB, Taylor RA. J Med Internet Res. 2024 Aug 2; 2024 Aug 2. PMID: 39094112.", + "Benchmarking Emergency Physician EHR Time per Encounter Based on Patient and Clinical Factors. Iscoe MS, Venkatesh AK, Holland ML, Krumholz HM, Sheares KD, Melnick ER. JAMA Netw Open. 2024 Aug 1; 2024 Aug 1. PMID: 39136949.", + "Nursing Home to Emergency Care Transition Form Has Limited Uptake But Improves Documentation. Serina PT, Stavrand A, Lind ML, Gettel CJ, Southerland LT, Goldberg EM. J Am Med Dir Assoc. 2024 Aug; 2024 Jun 4. PMID: 38843872.", + "2023 Society for Academic Emergency Medicine Consensus Conference on Precision Emergency Medicine: Development of a policy-relevant, patient-centered research agenda. Strehlow M, Gisondi MA, Caretta-Weyer H, Ankel F, Brackett A, Brar P, Chan TM, Garabedian A, Gunn B, Isaacs E, von Isenburg M, Jarman A, Kuehl D, Limkakeng AT, Lydston M, McGregor A, Pierce A, Raven MC, Salhi RA, Stave C, Tan J, Taylor RA, Wong HN, Yiadom MYAB, Zachrison KS, Vogel J. Acad Emerg Med. 2024 Aug; 2024 May 23. PMID: 38779704.", + "Estimating the size and scope of the academic emergency physician workforce. Gettel CJ, Camargo CA Jr, Bennett CL, Courtney DM, Kaji AH, Fermann GJ, Gallahue FE, Nelson LS, Hebbard CF, Rothenberg C, Raja AS, Venkatesh AK. Acad Emerg Med. 2024 Aug; 2024 May 20. PMID: 38769602.", + "The association between prolonged SARS-CoV-2 symptoms and work outcomes. Venkatesh AK, Yu H, Malicki C, Gottlieb M, Elmore JG, Hill MJ, Idris AH, Montoy JCC, O'Laughlin KN, Rising KL, Stephens KA, Spatz ES, Weinstein RA. PLoS One. 2024; 2024 Jul 29. PMID: 39074096.", + "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After SARS-CoV-2 Infection. Unger ER, Lin JS, Wisk LE, Yu H, L'Hommedieu M, Lavretsky H, Montoy JCC, Gottlieb MA, Rising KL, Gentile NL, Santangelo M, Venkatesh AK, Rodriguez RM, Hill MJ, Geyer RE, Kean ER, Saydah S, McDonald SA, Huebinger R, Idris AH, Dorney J, Hota B, Spatz ES, Stephens KA, Weinstein RA, Elmore JG. JAMA Netw Open. 2024 Jul 1; 2024 Jul 1. PMID: 39046739.", + "Impact of the geriatric emergency medicine specialist intervention on final emergency department disposition. Cohen I, Sangal RB, Taylor RA, Crawford A, Lai JM, Martin P, Palleschi S, Rothenberg C, Tomasino D, Hwang U. J Am Geriatr Soc. 2024 Jul; 2024 Apr 26. PMID: 38667266.", + "Calculation of Overall Hospital Quality Star Ratings With and Without Inclusion of the Peer Grouping Step. Gettel CJ, Bagshaw K, Qin L, Lin Z, Rothenberg E, Omotosho P, Goutos DP, Herrin J, Suter LG, Schreiber M, Fleisher LA, Myers R, Venkatesh AK. JAMA Netw Open. 2024 May 1; 2024 May 1. PMID: 38753326.", + "\"Follow-up in a few days\": Limitations to primary care access among older adults following emergency department discharge. Gettel CJ, Hartzheim J, Chera T, Galske J, Cameron-Comasco L, Bellolio F, Berrin LL, Venkatesh AK. J Am Geriatr Soc. 2024 May; 2024 Feb 2. PMID: 38308394.", + "The state of emergency medicine in Greece: at critical momentum. Tsiftsis D, Ulrich A, Notas G, Patrikakou A, Reid E. Int J Emerg Med. 2024 Apr 3; 2024 Apr 3. PMID: 38566013.", + "Pre-COVID-19 hospital quality and hospital response to COVID-19: examining associations between risk-adjusted mortality for patients hospitalised with COVID-19 and pre-COVID-19 hospital quality. Peter D, Li SX, Wang Y, Zhang J, Grady J, McDowell K, Norton E, Lin Z, Bernheim S, Venkatesh AK, Fleisher LA, Schreiber M, Suter LG, Triche EW. BMJ Open. 2024 Mar 29; 2024 Mar 29. PMID: 38553067.", + "Patient-reported outcome measure use among older adults after emergency department care: A systematic review. Gettel CJ, Galske J, Sather AR, Haidous AK, Hwang U, Brackett AL, Venkatesh AK, Rising KL, Goldberg EM, van Oppen JD, Conroy SP, Carpenter CR. Acad Emerg Med. 2024 Mar; 2024 Feb 17. PMID: 38366698.", + "Leveraging a Learning Collaborative Model to Develop and Pilot Quality Measures to Improve Opioid Prescribing in the Emergency Department. Hawk KF, Weiner SG, Rothenberg C, Bernstein E, D'Onofrio G, Herring A, Hoppe J, Ketcham E, LaPietra A, Nelson L, Perrone J, Ranney M, Samuels EA, Strayer R, Sharma D, Goyal P, Schuur J, Venkatesh AK. Ann Emerg Med. 2024 Mar; 2023 Oct 11. PMID: 37831040.", + "Correction: How Does ChatGPT Perform on the United States Medical Licensing Examination (USMLE)? The Implications of Large Language Models for Medical Education and Knowledge Assessment. Gilson A, Safranek CW, Huang T, Socrates V, Chi L, Taylor RA, Chartash D. JMIR Med Educ. 2024 Feb 27; 2024 Feb 27. PMID: 38412478.", + "Formative evaluation of an emergency department clinical decision support system for agitation symptoms: a study protocol. Wong AH, Nath B, Shah D, Kumar A, Brinker M, Faustino IV, Boyce M, Dziura JD, Heckmann R, Yonkers KA, Bernstein SL, Adapa K, Taylor RA, Ovchinnikova P, McCall T, Melnick ER. BMJ Open. 2024 Feb 19; 2024 Feb 19. PMID: 38373857.", + "Reply to \"Considering Health Systems Worldwide: Point of View From a Middle-Income Country\". Tu LH, Melnick E, Venkatesh AK, Sheth KN, Navaratnam D, Yaesoubi R, Forman HP, Mahajan A. AJR Am J Roentgenol. 2024 Feb; 2024 Feb 28. PMID: 38294162.", + "Patient-Reported Outcome-Based Performance Measures in Alternative Payment Models: Current Use, Implementation Barriers, and Principles to Succeed. Gettel CJ, Suter LG, Bagshaw K, Sheares KD, Balestracci KMB, Lin Z, Venkatesh AK. Value Health. 2024 Feb; 2023 Dec 1. PMID: 38042334.", + "Inequities among patient placement in emergency department hallway treatment spaces. Tuffuor K, Su H, Meng L, Pinker E, Tarabar A, Van Tonder R, Chmura C, Parwani V, Venkatesh AK, Sangal RB. Am J Emerg Med. 2024 Feb; 2023 Nov 11. PMID: 38006634.", + "Cost-Effectiveness of CT, CTA, MRI, and Specialized MRI for Evaluation of Patients Presenting to the Emergency Department With Dizziness. Tu LH, Melnick E, Venkatesh AK, Sheth KN, Navaratnam D, Yaesoubi R, Forman HP, Mahajan A. AJR Am J Roentgenol. 2024 Feb; 2023 Nov 8. PMID: 37937837.", + "Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) RNA and viable virus contamination of hospital emergency department surfaces and association with patient coronavirus disease 2019 (COVID-19) status and aerosol-generating procedures. Roberts SC, Barbell ES, Barber D, Dahlberg SE, Heimer R, Jubanyik K, Parwani V, Pettigrew MM, Tanner JM, Ulrich A, Wade M, Wyllie AL, Yolda-Carr D, Martinello RA, Tanner WD. Infect Control Hosp Epidemiol. 2024 Feb; 2023 Sep 28. PMID: 37767709.", + "Maps & Directions", + "Calendar", + "Contact Us", + "", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Vesely Laboratory", + "lab_url": "https://medicine.yale.edu/lab/vesely/", + "research_bio": "INFORMATION FOR The Vesely Lab focuses on understanding the function of immune inhibitory receptors, sometimes referred to as “immune checkpoints,” in autoimmune skin diseases and skin cancer. We employ cutting-edge techniques such as spatial proteomics and transcriptomics in both human patient samples and mouse models of disease to decipher key inflammatory pathways involved in these disorders. Specifically, we focus on cutaneous lupus erythematosus and lichen planus that lack FDA-approved therapies as well as psoriasis and atopic dermatitis where additional therapies are still needed. Finally, we investigate novel immunoregulatory pathways involved in cancer immune evasion in melanoma and cutaneous squamous cell carcinoma. Our goal is to visualize immunoregulatory patterns in cutaneous autoimmunity and cutaneous malignancies to identify new therapeutic targets. Copy Link Assistant Professor of Dermatology Postgraduate Associate Postdoctoral Associate Copy Link Copy Link We are looking for smart, creative, and collaborative individuals to join our team: Students are encouraged to email Dr. Vesely to discuss laboratory rotations. For post-doctoral candidates and scientist positions, please email a CV, cover letter, and contact information for three references toDr. Vesely. Copy Link We thank the following funding organizations for supporting or past and current research: Copy Link", + "publications_page": "https://medicine.yale.edu/lab/vesely/publications/", + "publications": [ + "Yale School of Medicine /", + "Dermatology /", + "Research", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Publications", + "", + "", + "", + "", + "", + "", + "Spatial transcriptomics and proteomics of mycosis fungoides biopsies from skin of color patients reveal biomarkers and potential treatment targets. Amechi C, Shakiba S, Rookey AK, James N, Nagarkar A, Cano-Ruiz C, Desse S, Nwade N, Yוldוz-Altay Ü, Kannan S, Cicuto T, Baer C, Svoboda R, Shokrani B, Vesely MD, Okoye GA, Byrd AS, Richmond JM. J Invest Dermatol. 2025 Nov 12; 2025 Nov 12. PMID: 41237899.", + "The treatment of cutaneous immune-related adverse events from immune checkpoint inhibitors with biologic therapy: A single-institution retrospective study at a tertiary care cancer center. Greenberg ABW, Valido K, Vesely M, Leventhal JS. J Am Acad Dermatol. 2025 Sep; 2025 May 7. PMID: 40345549.", + "Spatial Transcriptomics Reveals Differential Inflammatory Pathways in Discoid Lupus Erythematosus and Lichen Planus. Kidacki M, Cho C, Lopez-Giraldez F, Breidbart R, Jaiswal A, Lee M, Chowdhury S, Damsky W, Chen L, Vesely MD. J Invest Dermatol. 2025 Sep; 2025 Mar 18. PMID: 40113031.", + "PD-1H (VISTA) Expression in Cutaneous Squamous Cell Carcinoma Is Correlated with T-Cell Infiltration and Activation. Kidacki M, Cho C, Lopez-Giraldez F, Huang B, He J, Gaule P, Chen L, Vesely MD. J Invest Dermatol. 2025 Sep; 2025 Feb 19. PMID: 39983979.", + "Pathologist-Read vs AI-Driven Assessment of Tumor-Infiltrating Lymphocytes in Melanoma. Aung TN, Liu M, Su D, Shafi S, Boyaci C, Steen S, Tsiknakis N, Vidal JM, Maher N, Micevic G, Tan SX, Vesely MD, Nourmohammadi S, Bai Y, Djureinovic D, Wong PF, Bates K, Chan NNN, Gavirelatou N, He M, Burela S, Barna R, Bosic M, Bräutigam K, Illabochaca I, Chenhao Z, Gama J, Kreis B, Mohacsi R, Pillar N, Pinto J, Poulios C, Toli MA, Tzoras E, Bracero Y, Bosisio F, Cserni G, Dema A, Fortarezza F, Gonzalez MS, Gullo I, Queipo Gutiérrez FJ, Hacihasanoglu E, Jovic V, Lazar B, Olinca M, Neppl C, Oliveira RC, Pezzuto F, Gomes Pinto D, Plotar V, Pop O, Rau T, Skok K, Sun W, Serbes ED, Solass W, Stanowska O, Szasz M, Szymonski K, Thimm F, Vignati D, Vigdorovits A, Prieto V, Sinnberg T, Wilmott J, Cowper S, Warrell J, Saenger Y, Hartman J, Plummer J, Osman I, Rimm DL, Acs B. JAMA Netw Open. 2025 Jul 1; 2025 Jul 1. PMID: 40608341.", + "Immune Checkpoint Agonists for Inflammatory Skin Diseases. Vesely MD, Lizzul PF, Klekotka P, Joller N, Raff A. J Invest Dermatol. 2025 Jun; 2025 Feb 8. PMID: 39927905.", + "Spatial characterization of interface dermatitis in cutaneous lupus reveals novel chemokine ligand-receptor pairs that drive disease. Shakiba S, Haddadi NS, Afshari K, Lubov JE, Raef HS, Li R, Yildiz-Altay Ü, Daga M, Refat MA, Kim E, de Laflin JG, Akabane A, Romano P, Vongvirath J, Sherman S, MacDonald E, Strassner JP, Zhang L, Leon M, Baer CE, Dresser K, Liang Y, Whitley JB, Skopelja-Gardner S, Harris JE, Deng A, Vesely MD, Rashighi M, Richmond J. bioRxiv. 2025 May 22; 2025 May 22. PMID: 38260617.", + "Cutaneous Lupus Features Specialized Stromal Niches and Altered Retroelement Expression. Gehlhausen JR, Kong Y, Baker E, Ramachandran S, Koumpouras F, Ko CJ, Vesely M, Little AJ, Damsky W, King B, Iwasaki A. J Invest Dermatol. 2025 May 21; 2025 May 21. PMID: 40409678.", + "Representation of skin of color in patient education materials for discoid lupus erythematosus. Saeed SM, Ajoku E, Swallow MA, Vesely MD, Gehlhausen JR, Little AJ, Koumpouras F, Ramachandran S. Arch Dermatol Res. 2025 Mar 17; 2025 Mar 17. PMID: 40095060.", + "Mixed and undifferentiated autoimmune connective tissue diseases. Vesely MD. Clin Dermatol. 2025 Mar-Apr; 2024 Dec 15. PMID: 39681290.", + "Subcutaneous immunoglobulin-induced eczematous dermatitis. Breidbart R, Vesely MD. JAAD Case Rep. 2025 Feb; 2024 Dec 16. PMID: 39866341.", + "Type 2 immunity to the rescue: enhancing antitumor immunity for skin cancer prevention. Vesely MD, Christensen SR. J Clin Invest. 2025 Jan 2; 2025 Jan 2. PMID: 39744952.", + "Spatial Transcriptomics in Inflammatory Skin Diseases Using GeoMx Digital Spatial Profiling: A Practical Guide for Applications in Dermatology. Cho C, Haddadi NS, Kidacki M, Woodard GA, Shakiba S, Yıldız-Altay Ü, Richmond JM, Vesely MD. JID Innov. 2025 Jan; 2024 Sep 27. PMID: 39559817.", + "Association of lichen planus with asthma and allergic rhinitis in the All of Us Research Program: a cross-sectional study. Richmond RL, Murphy MJ, Edemobi P, Vesely MD, Cohen JM. Clin Exp Dermatol. 2024 Aug 22. PMID: 38589773.", + "Intravenous immunoglobulin-induced eczematous dermatitis treated with dupilumab. Singh K, Breidbart R, Jaiswal A, Damsky W, Choate KA, Vesely M. JAAD Case Rep. 2024 Jul; 2024 May 10. PMID: 38952857.", + "Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity. Zhang T, Yu W, Cheng X, Yeung J, Ahumada V, Norris PC, Pearson MJ, Yang X, van Deursen W, Halcovich C, Nassar A, Vesely MD, Zhang Y, Zhang JP, Ji L, Flies DB, Liu L, Langermann S, LaRochelle WJ, Humphrey R, Zhao D, Zhang Q, Zhang J, Gu R, Schalper KA, Sanmamed MF, Chen L. Sci Immunol. 2024 Apr 26; 2024 Apr 26. PMID: 38669316.", + "Immune Inhibitory Molecule PD-1 Homolog (VISTA) Colocalizes with CD11b Myeloid Cells in Melanoma and Is Associated with Poor Outcomes. Vesely MD, Kidacki M, Gaule P, Gupta S, Chan NNN, Han X, Yeung JT, Chen L. J Invest Dermatol. 2024 Jan; 2023 Aug 8. PMID: 37562584.", + "Clinical and research updates on the VISTA immune checkpoint: immuno-oncology themes and highlights. Noelle RJ, Lines JL, Lewis LD, Martell RE, Guillaudeux T, Lee SW, Mahoney KM, Vesely MD, Boyd-Kirkup J, Nambiar DK, Scott AM. Front Oncol. 2023; 2023 Sep 15. PMID: 37795437.", + "HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease. Little AJ, Chen PM, Vesely MD, Khan RN, Fiedler J, Garritano J, Maisha FI, McNiff JM, Craft J. JCI Insight. 2023 Aug 22; 2023 Aug 22. PMID: 37526979.", + "Pembrolizumab-induced lichenoid dermatitis treated with dupilumab. Park JJ, Park E, Damsky WE, Vesely MD. JAAD Case Rep. 2023 Jul; 2023 May 16. PMID: 37332364.", + "Crusted Scabies Presenting as Erythroderma in a Patient With Iatrogenic Immunosuppression for Treatment of Granulomatosis With Polyangiitis. Olamiju B, Leventhal JS, Vesely MD. Cutis. 2023 May. PMID: 37406327.", + "Treatment of cutaneous lupus with topical ruxolitinib cream. Park JJ, Little AJ, Vesely MD. JAAD Case Rep. 2022 Oct; 2022 Aug 28. PMID: 36159722.", + "Cancer Immunoediting in the Era of Immuno-oncology. Gubin MM, Vesely MD. Clin Cancer Res. 2022 Sep 15. PMID: 35594163.", + "Amelanotic melanoma in a patient with Hermansky-Pudlak syndrome. Fan R, Johnston MS, Gowen MF, Damsky W, Odell I, Clune J, Vesely MD. JAAD Case Rep. 2022 Sep; 2022 Jul 6. PMID: 35990226.", + "Not all well-differentiated cutaneous squamous cell carcinomas are equal: Tumors with disparate biologic behavior have differences in protein expression via digital spatial profiling. Vesely M, Martinez-Morilla S, Gehlhausen JR, McNiff JM, Whang PG, Rimm D, Ko CJ. J Am Acad Dermatol. 2022 Sep; 2022 Apr 6. PMID: 35398219.", + "The CD8α-PILRα interaction maintains CD8(+) T cell quiescence. Zheng L, Han X, Yao S, Zhu Y, Klement J, Wu S, Ji L, Zhu G, Cheng X, Tobiasova Z, Yu W, Huang B, Vesely MD, Wang J, Zhang J, Quinlan E, Chen L. Science. 2022 May 27; 2022 May 26. PMID: 35617401.", + "Treatment of lichen sclerosus and hypertrophic scars with dupilumab. Peterson DM, Damsky WE, Vesely MD. JAAD Case Rep. 2022 May; 2022 Mar 22. PMID: 35445148.", + "Paradoxical eruptions to targeted therapies in dermatology: A systematic review and analysis. Murphy MJ, Cohen JM, Vesely MD, Damsky W. J Am Acad Dermatol. 2022 May; 2020 Dec 8. PMID: 33307146.", + "Resistance Mechanisms to Anti-PD Cancer Immunotherapy. Vesely MD, Zhang T, Chen L. Annu Rev Immunol. 2022 Apr 26. PMID: 35471840.", + "Fever, Hypotension, and a Worsening Necrotic Wound. Peterson DM, Damsky WE, Vesely MD. JAMA. 2022 Apr 19. PMID: 35311923.", + "T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma. Lozano AX, Chaudhuri AA, Nene A, Bacchiocchi A, Earland N, Vesely MD, Usmani A, Turner BE, Steen CB, Luca BA, Badri T, Gulati GS, Vahid MR, Khameneh F, Harris PK, Chen DY, Dhodapkar K, Sznol M, Halaban R, Newman AM. Nat Med. 2022 Feb; 2022 Jan 13. PMID: 35027754.", + "A pruritic psoriatic plaque develops at the donor site of an autologous skin graft: Koebner phenomenon. Murphy MJ, Damsky W, Vesely MD. Lancet. 2021 Nov 13. PMID: 34774145.", + "Targeting the CSF1/CSF1R axis is a potential treatment strategy for malignant meningiomas. Yeung J, Yaghoobi V, Miyagishima D, Vesely MD, Zhang T, Badri T, Nassar A, Han X, Sanmamed MF, Youngblood M, Peyre M, Kalamarides M, Rimm DL, Gunel M, Chen L. Neuro Oncol. 2021 Nov 2. PMID: 33914067.", + "A Burned-Out CD8(+) T-cell Subset Expands in the Tumor Microenvironment and Curbs Cancer Immunotherapy. Sanmamed MF, Nie X, Desai SS, Villaroel-Espindola F, Badri T, Zhao D, Kim AW, Ji L, Zhang T, Quinlan E, Cheng X, Han X, Vesely MD, Nassar AF, Sun J, Zhang Y, Kim TK, Wang J, Melero I, Herbst RS, Schalper KA, Chen L. Cancer Discov. 2021 Jul; 2021 Mar 3. PMID: 33658301.", + "Cytokine RNA In Situ Hybridization Permits Individualized Molecular Phenotyping in Biopsies of Psoriasis and Atopic Dermatitis. Wang A, Fogel AL, Murphy MJ, Panse G, McGeary MK, McNiff JM, Bosenberg M, Vesely MD, Cohen JM, Ko CJ, King BA, Damsky W. JID Innov. 2021 Jun; 2021 May 7. PMID: 34909719.", + "Necrotic papulonodules on the legs. Zhou A, Damsky W, Girardi M, Foss FM, Vesely MD. JAAD Case Rep. 2021 May; 2021 Mar 13. PMID: 33898676.", + "Remission of severe atopic dermatitis with dupilumab and rescue tofacitinib therapy. Peterson DM, Vesely MD. JAAD Case Rep. 2021 Apr; 2021 Feb 3. PMID: 33728367.", + "Spatially Resolved and Quantitative Analysis of the Immunological Landscape in Human Meningiomas. Yeung J, Yaghoobi V, Aung TN, Vesely MD, Zhang T, Gaule P, Gunel M, Rimm DL, Chen L. J Neuropathol Exp Neurol. 2021 Jan 20. PMID: 33393633.", + "Onychodystrophy associated with dupilumab therapy for atopic dermatitis. Zubek AE, Vesely MD. JAAD Case Rep. 2021 Jan; 2020 Nov 7. PMID: 33318995.", + "Caution in the time of rashes and COVID-19. Vesely MD, Perkins SH. J Am Acad Dermatol. 2020 Oct; 2020 Jul 15. PMID: 32682026.", + "Normalization Cancer Immunotherapy for Melanoma. Vesely MD, Chen L. J Invest Dermatol. 2020 Jun; 2020 Feb 22. PMID: 32092349.", + "A rapidly growing, exophytic nodule on the chest. Ramseier JY, Cowper SE, Leventhal JS, Vesely MD. JAAD Case Rep. 2020 May; 2020 Apr 29. PMID: 32382633.", + "In silico analysis of the immunological landscape of pituitary adenomas. Yeung JT, Vesely MD, Miyagishima DF. J Neurooncol. 2020 May; 2020 Mar 31. PMID: 32236778.", + "Successful treatment of alopecia totalis with ruxolitinib in a preadolescent patient. Peterson DM, Vesely MD. JAAD Case Rep. 2020 Apr; 2020 Mar 24. PMID: 32258291.", + "Getting Under the Skin: Targeting Cutaneous Autoimmune Disease. Vesely MD. Yale J Biol Med. 2020 Mar; 2020 Mar 27. PMID: 32226348.", + "Cutaneous Lupus Erythematosus: Current and Future Pathogenesis-Directed Therapies. Little AJ, Vesely MD. Yale J Biol Med. 2020 Mar; 2020 Mar 27. PMID: 32226339.", + "Tense Bullae and Pruritus. Vesely MD, Olamiju BA, Leventhal JS. Am Fam Physician. 2020 Mar 1. PMID: 32109022.", + "PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus. Han X, Vesely MD, Yang W, Sanmamed MF, Badri T, Alawa J, López-Giráldez F, Gaule P, Lee SW, Zhang JP, Nie X, Nassar A, Boto A, Flies DB, Zheng L, Kim TK, Moeckel GW, McNiff JM, Chen L. Sci Transl Med. 2019 Dec 11. PMID: 31826980.", + "Drug-induced hypersensitivity syndrome with myocardial involvement treated with tofacitinib. Damsky WE, Vesely MD, Lee AI, Choi J, Meyer AC, Chen M, Ahmad T, King B. JAAD Case Rep. 2019 Dec; 2019 Nov 13. PMID: 31763425.", + "Stimulating T Cells Against Cancer With Agonist Immunostimulatory Monoclonal Antibodies. Han X, Vesely MD. Int Rev Cell Mol Biol. 2019; 2018 Aug 20. PMID: 30635089.", + "Tofacitinib citrate for the treatment of refractory, severe chronic actinic dermatitis. Vesely MD, Imaeda S, King BA. JAAD Case Rep. 2017 Jan; 2016 Dec 21. PMID: 28050588.", + "A Serendipitous Retreat into Research Techniques Made Simple. Vesely MD. J Invest Dermatol. 2016 Dec. PMID: 27884294.", + "Recurrent Coxsackievirus Infection in a Patient with Lamellar Ichthyosis. Damsky WE, Leventhal JS, Khalil D, Vesely MD, Craiglow BG, Milstone LM, Choate KA. Pediatr Dermatol. 2016 Mar-Apr; 2016 Jan 29. PMID: 26821985.", + "Maps & Directions", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Weinberger Lab", + "lab_url": "https://medicine.yale.edu/lab/weinberger/", + "research_bio": "INFORMATION FOR Our research focuses on the mechanisms driving the observed epidemiological patterns of respiratory infections, particularly pneumococcal disease and RSV. Pneumococcus causes a large burden of disease worldwide, particularly among young children and the elderly. Major research questions in the lab are related to long-term bacterial evolution, impacts of immunization on carriage and disease in different populations, and seasonal determinants of bacterial disease incidence (including viral co-infections and carriage). These projects utilize both quantitative tools and experimental laboratory studies. You can learn more about our research and recent publicationshere. Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/weinberger/publications/", + "publications": null + }, + { + "lab_name": "Wu Lab", + "lab_url": "https://medicine.yale.edu/lab/wu/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "XLiu Lab", + "lab_url": "https://medicine.yale.edu/lab/x-liu/", + "research_bio": "INFORMATION FOR The Liu lab studies artificial intelligence for medical image analysis. Our research interests are centered around the convergence of deep learning, medical imaging, and data science to advance the diagnosis, prognosis, and treatment monitoring of various diseases. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/x-liu/publications/", + "publications": null + }, + { + "lab_name": "Xu Laboratory", + "lab_url": "https://medicine.yale.edu/lab/kexu/", + "research_bio": "INFORMATION FOR Our goals are to understand genetic and epigenetic mechanisms of addiction in humans and to translate genetic findings to clinical use. The projects in our lab have focused on identifying genetic risks for addictive behavior and substance misuse-related psychiatric disorders. In recent years, we have been interested in understanding how substance (e.g., alcohol, tobacco, cocaine, opiates, and cannabis) misuse impacts epigenome and transcriptome that contribute to psychiatric and medical diseases. We are also interested in the impact of substance misuse on immune cells between the peripheral and central nervous system. The approaches we have used include genetic (Genome-wide association study), epigenetic (Array-based and Sequencing-Based Methylome-wide Association Study), and transcriptomic (bulk RNA-sequencing and single-cell RNA sequencing) analysis. We use computational methods to link our genetic findings to predict clinical outcomes. We also use in-vivo and in-vitro cell models treated with active compounds to understand the impact of substances on peripheral immune function. We currently have an open post-doctoral position, pleasevisit the Positions sectionfor more information, orcontact Dr. Ke Xu, MD, PhD. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/kexu/publications", + "publications": null + }, + { + "lab_name": "Ya-Chi Ho Lab", + "lab_url": "https://medicine.yale.edu/lab/yachiho/", + "research_bio": "INFORMATION FOR Despite effective antiretroviral therapy, HIV persists as an integrated provirus. These HIV-infected cells are resistant to immune clearance and antiretroviral therapy. Upon treatment interruptions, viral rebound will resume. Therefore, all HIV-infected individuals need to take life-long antiretroviral therapy. Given the adverse effects, drug resistance and economical burden of lifelong antiretroviral therapy, a cure is needed to control the global HIV endemic. The mission of the Ho lab is to understand HIV persistence and find a cure for HIV infections. The scientific goal is to understand how HIV persists in cells, particularly CD4 T lymphocytes, and whether epigenetic silencing can permanently and irreversibly silence HIV expression. We use a molecular virology approach to examine mechanisms of HIV persistence using blood samples from HIV-infected individuals. We are currently recruiting postdocs working on a combination of HIV-induced immune dysfunction, single-cell genomics, and bioinformatics. Despite effective antiretroviral therapy (ART), HIV persists in the latent reservoir as the major barrier to cure. Although ART effectively suppresses plasma viral load to clinically undetectable levels, once ART is interrupted, high levels of viremia will inevitably occur. Therefore, all 37 million people living with HIV need to take lifelong ART. This is because HIV hides in the memory CD4+T cells and evades immune clearance. First, HIV stably integrates into chromosomes of infected cells. ART cannot remove these integrated proviruses. Second, HIV infects the long-lived memory CD4+T cells and persists for decades. Third, HIV enters latency and becomes transcriptionally silent when memory CD4+T cells return to a quiescent state. Latently infected cells do not express viral antigens and cannot be recognized and cleared by the immune system. Fourth, HIV-infected cells undergo clonal expansion through antigen stimulation, homeostatic cytokine-mediated proliferation, and integration-site driven proliferation. This means that HIV-infected cells not only survive but also increase over time. Finally, despite ART, millions of HIV-infected cells already established the latent reservoir within 3 days of infection. Since ART does not inhibit HIV LTR promoter activity, these infected cells express viral antigens through stochastic activation and continue to induce immune activation and immune exhaustion. The exhausted and dysfunctional immune effector cells cannot effectively eliminate HIV-infected cells. A cure is desperately needed. However, manyquestionsremain unsolved: how does virally suppressed HIV infection induce chronic immune exhaustion? How do HIV-infected cells survive, proliferate, and persist over time? How can we specifically target HIV-infected CD4+T cells without harming uninfected cells? Our goalis to understand how HIV induces immune dysfunction over different stages of HIV infection over time, both at the systemic level characterizing all CD4+T cells and the single-cell level in HIV-infected cells. We will focus on CD4+T cells, the central orchestrator of adaptive immunity and the major target of HIV infection. Wehypothesizethat despite the heterogeneity of HIV-infected cells, HIV drives a distinct cellular program that promotes persistence. We propose that identifying and targeting HIV-driven immune dysregulation leads to cure. Thechallengeto answering this question is the heterogeneity, rarity, and lack of marker of HIV-infected cells. Ourapproachis to develop cutting-edge single-cell methods, to apply these methods to challenging clinical samples, and to validate with CRISPR-mediated up- and down-regulation of candidate cellular pathways. Copy Link Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/yachiho/publications/", + "publications": null + }, + { + "lab_name": "Yale Clinical Neuroscience Neuroanalytics", + "lab_url": "https://medicine.yale.edu/lab/ynn/", + "research_bio": "INFORMATION FOR Copy Link Copy Link Copy Link Copy Link Copy Link Copy Link Copy Link Copy Link Copy Link Copy Link Daniel Bacheschi Alice Huang Tamara Jafar Gabe Ransom Mani Ratnesh Sandhu Marcus Woods Mohsen Nami Evan Collins Hari McGrath Omar Chishti Kelly Pu Karen Kirunda Copy Link Group Contact, Brain Atlas Harvey and Kate Cushing Professor Emeritus and Senior Research Scientist of Neurosurgery; Director Epilepsy Research, Neurosurgery Neuroengineering, Computational Neurophysiology Associate Professor of Neurology Neurochemistry Professor of Laboratory Medicine, of Neurosurgery, and of Cellular and Molecular Physiology; Vice Chair for Education, Department of Laboratory Medicine; Director of Medical Education, Department of Cellular and Molecular Physiology; Thread Leader, Physiology, Office of Education; Associate Director, Clinical Chemistry Laboratory, Yale-New Haven Hospital", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Yale Interventional Oncology Research Lab", + "lab_url": "https://medicine.yale.edu/lab/radresearch/", + "research_bio": "INFORMATION FOR With our research in Interventional Oncology, we aspire to improve the detection, characterization, and treatment of neoplastic disease in the liver. This includes the full breadth of translational research in basic science, pre-clinical, and clinical activities. “There is a single light of science, and to brighten it anywhere is to brighten it everywhere.” — Isaac Asimov Copy Link", + "publications_page": "https://medicine.yale.edu/lab/radresearch/publications/", + "publications": [ + "Yale School of Medicine /", + "Radiology & Biomedical Imaging /", + "Research", + "Contact Us", + "Faculty & Researchers Affiliated Faculty Alumni", + "Affiliated Faculty", + "Alumni", + "Student Research Exchange Program Summer Scholarship", + "Exchange Program", + "Summer Scholarship", + "Publications/News Highlighted Publications News", + "Highlighted Publications", + "News", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Home", + "Publications/News", + "Highlighted Publications", + "News", + "", + "", + "", + "", + "", + "", + "Radiomics beyond the visible - Decoding tumor heterogeneity to guide combination therapy of intermediate stage HCC. Lotter W, Chapiro J. Hepatology. 2025 Nov 17; 2025 Nov 17. PMID: 41247826.", + "On Hallucinations in Artificial Intelligence-Generated Content for Nuclear Medicine Imaging (the DREAM Report). Xia M, Bayerlein R, Chemli Y, Liu X, Ouyang J, Lin M, El Fakhri G, Badawi RD, Li Q, Liu C. J Nucl Med. 2025 Nov 6; 2025 Nov 6. PMID: 41198241.", + "The Role of AI in Clinical Trial Design and Scientific Writing. Antonakea NK, Chapiro J, Geschwind J. Cardiovasc Intervent Radiol. 2025 Oct 6; 2025 Oct 6. PMID: 41053471.", + "Publisher Correction: Interventional Radiology Reporting Standards and Checklist for Artificial Intelligence Research Evaluation (iCARE). Anibal JT, Huth HB, Boeken T, Daye D, Gichoya J, Muñoz FG, Chapiro J, Wood BJ, Sze DY, Hausegger K. Cardiovasc Intervent Radiol. 2025 Oct. PMID: 40925982.", + "Interventional Radiology Reporting Standards and Checklist for Artificial Intelligence Research Evaluation (iCARE). Anibal JT, Huth HB, Boeken T, Daye D, Gichoya J, Muñoz FG, Chapiro J, Wood BJ, Sze DY, Hausegger K. J Vasc Interv Radiol. 2025 Sep; 2025 Mar 10. PMID: 40086722.", + "Noninvasive Tumor Profiling: Quantitative Contrast-Enhanced MRI Markers Predict PD-L1 and CTNNB1 Status in Hepatocellular Carcinoma. Matuschewski NJ, Sobirey R, Revzin M, Zeevi T, Gross M, Kasolowsky V, Shewarega A, Meister E, Kao T, Tefera J, Bousabarah K, Batra R, Strazzabosco M, Lin M, Gebauer B, Savic LJ, Duncan J, Madoff DC, Zhang X, Chapiro J. Radiology. 2025 Aug. PMID: 40762840.", + "Interventional Radiology Reporting Standards and Checklist for Artificial Intelligence Research Evaluation (iCARE). Anibal JT, Huth HB, Boeken T, Daye D, Gichoya J, Muñoz FG, Chapiro J, Wood BJ, Sze DY, Hausegger K. Cardiovasc Intervent Radiol. 2025 Aug; 2025 Jun 25. PMID: 40560391.", + "Image-Based Search in Radiology: Identification of Brain Tumor Subtypes within Databases Using MRI-Based Radiomic Features. von Reppert M, Chadha S, Willms K, Avesta A, Maleki N, Zeevi T, Lost J, Tillmanns N, Jekel L, Merkaj S, Lin M, Hoffmann KT, Aneja S, Aboian MS. AJNR Am J Neuroradiol. 2025 Jul 1; 2025 Jul 1. PMID: 40250848.", + "Portal and Hepatic Vein Embolization versus Portal Venous Embolization Alone in Cirrhotic and Noncirrhotic Swine: A Pilot Study. Tefera J, Kuhn TN, Matuschewski NJ, Meister E, Nguyenová J, Kao T, Mutonga M, Bitar R, Kahl VH, Zhang X, Shewarega A, Chapiro J, Madoff DC. J Vasc Interv Radiol. 2025 Jun; 2025 Mar 3. PMID: 40043833.", + "Endovascular Embolization versus Observation of Congenital Renal Arteriovenous Malformations: A Retrospective Study. Hufnagle JJ 4th, Fish A, Schlachter T. J Vasc Interv Radiol. 2025 Jun; 2025 Feb 10. PMID: 39938714.", + "Volumetric Abdominal Aortic Aneurysm Analysis in Post EVAR Surveillance Settings. Simmons K, Weiss D, Aboian M, Lin M, Bousabarah K, Renninghoff D, Holler W, Deuschl C, Fischer U, Aboian E. Ann Vasc Surg. 2025 May; 2025 Mar 4. PMID: 40049548.", + "Commentary on: Comparative Analysis of Systemic Immune Responses and Metastatic Risks in Tumor Ablation: An Animal Study of Radiofrequency Ablation and Irreversible Electroporation with Immune Modulation. Gois Santana J, Chapiro J. Cardiovasc Intervent Radiol. 2025 Apr; 2025 Mar 17. PMID: 40097621.", + "Comparison of prognostic accuracy of HCC staging systems in patients undergoing TACE. Kasolowsky V, Gross M, Madoff DC, Duncan J, Taddei T, Strazzabosco M, Jaffe A, Chapiro J. Clin Imaging. 2025 Apr; 2025 Feb 25. PMID: 40049074.", + "Molecular MRI of T-cell immune response to cryoablation in immunologically hot vs. cold hepatocellular carcinoma. Santana JG, Shewarega A, Nam D, Duncan J, Madoff DC, Hyder F, Coman D, Chapiro J. JHEP Rep. 2025 Mar; 2024 Dec 4. PMID: 40028344.", + "Artificial Intelligence-Driven Patient Selection for Preoperative Portal Vein Embolization for Patients with Colorectal Cancer Liver Metastases. Kuhn TN, Engelhardt WD, Kahl VH, Alkukhun A, Gross M, Iseke S, Onofrey J, Covey A, Camacho JC, Kawaguchi Y, Hasegawa K, Odisio BC, Vauthey JN, Antoch G, Chapiro J, Madoff DC. J Vasc Interv Radiol. 2025 Mar; 2024 Dec 3. PMID: 39638087.", + "IR Physician Compensation at U.S. Medical Schools: Trends and Segments. Malhotra A, Futela D, Khunte M, Wu X, Payabvash S, Gandhi D, Chapiro J, Duszak R. J Vasc Interv Radiol. 2025 Feb; 2024 Oct 22. PMID: 39442649.", + "Tumor response assessment in hepatocellular carcinoma treated with immunotherapy: imaging biomarkers for clinical decision-making. Sobirey R, Matuschewski N, Gross M, Lin M, Kao T, Kasolowsky V, Strazzabosco M, Stein S, Savic LJ, Gebauer B, Jaffe A, Duncan J, Madoff DC, Chapiro J. Eur Radiol. 2025 Jan; 2024 Jul 20. PMID: 39033181.", + "The Brain Tumor Segmentation - Metastases (BraTS-METS) Challenge 2023: Brain Metastasis Segmentation on Pre-treatment MRI. Moawad AW, Janas A, Baid U, Ramakrishnan D, Saluja R, Ashraf N, Maleki N, Jekel L, Yordanov N, Fehringer P, Gkampenis A, Amiruddin R, Manteghinejad A, Adewole M, Albrecht J, Anazodo U, Aneja S, Anwar SM, Bergquist T, Chiang V, Chung V, Conte GM, Dako F, Eddy J, Ezhov I, Khalili N, Farahani K, Iglesias JE, Jiang Z, Johanson E, Kazerooni AF, Kofler F, Krantchev K, LaBella D, Van Leemput K, Li HB, Linguraru MG, Liu X, Meier Z, Menze BH, Moy H, Osenberg K, Piraud M, Reitman Z, Shinohara RT, Wang C, Wiestler B, Wiggins W, Shafique U, Willms K, Avesta A, Bousabarah K, Chakrabarty S, Gennaro N, Holler W, Kaur M, LaMontagne P, Lin M, Lost J, Marcus DS, Maresca R, Merkaj S, Cassinelli Pedersen G, von Reppert M, Sotiras A, Teytelboym O, Tillmans N, Westerhoff M, Youssef A, Godfrey D, Floyd S, Rauschecker A, Villanueva-Meyer J, Pflüger I, Cho J, Bendszus M, Brugnara G, Cramer J, Perez-Carillo GJG, Johnson DR, Kam A, Kwan BYM, Lai L, Lall NU, Memon F, Krycia M, Patro SN, Petrovic B, So TY, Thompson G, Wu L, Schrickel EB, Bansal A, Barkhof F, Besada C, Chu S, Druzgal J, Dusoi A, Farage L, Feltrin F, Fong A, Fung SH, Gray RI, Ikuta I, Iv M, Postma AA, Mahajan A, Joyner D, Krumpelman C, Letourneau-Guillon L, Lincoln CM, Maros ME, Miller E, Morón FEA, Nimchinsky EA, Ozsarlak O, Patel U, Rohatgi S, Saha A, Sayah A, Schwartz ED, Shih R, Shiroishi MS, Small JE, Tanwar M, Valerie J, Weinberg BD, White ML, Young R, Zohrabian VM, Azizova A, Brüßeler MMT, Ghonim M, Ghonim M, Okar A, Pasquini L, Sharifi Y, Singh G, Sollmann N, Soumala T, Taherzadeh M, Vollmuth P, Foltyn-Dumitru M, Malhotra A, Abayazeed AH, Dellepiane F, Lohmann P, Pérez-García VM, Elhalawani H, de Verdier MC, Al-Rubaiey S, Armindo RD, Ashraf K, Asla MM, Badawy M, Bisschop J, Lomer NB, Bukatz J, Chen J, Cimflova P, Corr F, Crawley A, Deptula L, Elakhdar T, Shawali IH, Faghani S, Frick A, Gulati V, Haider MA, Hierro F, Dahl RH, Jacobs SM, Hsieh KJ, Kandemirli SG, Kersting K, Kida L, Kollia S, Koukoulithras I, Li X, Abouelatta A, Mansour A, Maria-Zamfirescu RC, Marsiglia M, Mateo-Camacho YS, McArthur M, McDonnell O, McHugh M, Moassefi M, Morsi SM, Munteanu A, Nandolia KK, Naqvi SR, Nikanpour Y, Alnoury M, Nouh AMA, Pappafava F, Patel MD, Petrucci S, Rawie E, Raymond S, Roohani B, Sabouhi S, Sanchez-Garcia LM, Shaked Z, Suthar PP, Altes T, Isufi E, Dhemesh Y, Gass J, Thacker J, Tarabishy AR, Turner B, Vacca S, Vilanilam GK, Warren D, Weiss D, Worede F, Yousry S, Lerebo W, Aristizabal A, Karargyris A, Kassem H, Pati S, Sheller M, Link KEE, Calabrese E, Tahon NH, Nada A, Velichko YS, Bakas S, Rudie JD, Aboian M. ArXiv. 2024 Dec 9; 2024 Dec 9. PMID: 37396600.", + "Breaking Ground on the Application of AI to HCC: It's All about Data. Bitar R, Chapiro J. Radiol Artif Intell. 2024 Nov. PMID: 39601669.", + "Interventional Oncology Meets Immuno-oncology: Combination Therapies for Hepatocellular Carcinoma. Bitar R, Salem R, Finn R, Greten TF, Goldberg SN, Chapiro J. Radiology. 2024 Nov. PMID: 39560477.", + "Outcomes of repeat conventional transarterial chemoembolization in patients with liver metastases. Ghabili K, Windham-Herman AM, Konstantinidis M, Murali N, Borde T, Adam LC, Laage-Gaupp F, Lin M, Chapiro J, Georgiades C, Nezami N. Ann Hepatol. 2024 Nov-Dec; 2024 Jul 19. PMID: 39033928.", + "Criteria for PAVM Reintervention. Fish A, Knight E, Henderson K, Pollak J, Schlachter T. J Clin Med. 2024 Oct 13; 2024 Oct 13. PMID: 39458055.", + "Enhancing clinical decision-making: An externally validated machine learning model for predicting isocitrate dehydrogenase mutation in gliomas using radiomics from presurgical magnetic resonance imaging. Lost J, Ashraf N, Jekel L, von Reppert M, Tillmanns N, Willms K, Merkaj S, Petersen GC, Avesta A, Ramakrishnan D, Omuro A, Nabavizadeh A, Bakas S, Bousabarah K, Lin M, Aneja S, Sabel M, Aboian M. Neurooncol Adv. 2024 Jan-Dec; 2024 Oct 3. PMID: 39659829.", + "Automated graded prognostic assessment for patients with hepatocellular carcinoma using machine learning. Gross M, Haider SP, Ze'evi T, Huber S, Arora S, Kucukkaya AS, Iseke S, Gebauer B, Fleckenstein F, Dewey M, Jaffe A, Strazzabosco M, Chapiro J, Onofrey JA. Eur Radiol. 2024 Oct; 2024 Mar 27. PMID: 38536464.", + "Recurrence of Pulmonary Arteriovenous Malformation after Embolization in Patients with Pulmonary Hypertension. Fish A, Wang D, Knight E, Pollak J, Schlachter T. J Vasc Interv Radiol. 2024 Aug; 2024 Apr 29. PMID: 38692392.", + "High-resolution extracellular pH imaging of liver cancer with multiparametric MR using Deep Image Prior. Dong S, Shewarega A, Chapiro J, Cai Z, Hyder F, Coman D, Duncan JS. NMR Biomed. 2024 Aug; 2024 Mar 15. PMID: 38488205.", + "Automated MRI liver segmentation for anatomical segmentation, liver volumetry, and the extraction of radiomics. Gross M, Huber S, Arora S, Ze'evi T, Haider SP, Kucukkaya AS, Iseke S, Kuhn TN, Gebauer B, Michallek F, Dewey M, Vilgrain V, Sartoris R, Ronot M, Jaffe A, Strazzabosco M, Chapiro J, Onofrey JA. Eur Radiol. 2024 Aug; 2024 Jan 13. PMID: 38217704.", + "Correction to: Consensus report from the 10th Global Forum for Liver Magnetic Resonance Imaging: developments in HCC management. Taouli B, Ba-Ssalamah A, Chapiro J, Chhatwal J, Fowler K, Kang TW, Knobloch G, Koh DM, Kudo M, Lee JM, Murakami T, Pinato DJ, Ringe KI, Song B, Tabrizian P, Wang J, Yoon JH, Zeng M, Zhou J, Vilgrain V. Eur Radiol. 2024 Jul. PMID: 38112766.", + "ChatGPT: The transformative influence of generative AI on science and healthcare. Varghese J, Chapiro J. J Hepatol. 2024 Jun; 2023 Aug 5. PMID: 37544516.", + "Ethiodized oil as an imaging biomarker after conventional transarterial chemoembolization. Mendiratta-Lala M, Aslam A, Bai HX, Chapiro J, De Baere T, Miyayama S, Chernyak V, Matsui O, Vilgrain V, Fidelman N. Eur Radiol. 2024 May; 2023 Nov 6. PMID: 37930412.", + "Comparison of Volumetric and 2D Measurements and Longitudinal Trajectories in the Response Assessment of BRAF V600E-Mutant Pediatric Gliomas in the Pacific Pediatric Neuro-Oncology Consortium Clinical Trial. Ramakrishnan D, Brüningk SC, von Reppert M, Memon F, Maleki N, Aneja S, Kazerooni AF, Nabavizadeh A, Lin M, Bousabarah K, Molinaro A, Nicolaides T, Prados M, Mueller S, Aboian MS. AJNR Am J Neuroradiol. 2024 Apr 8; 2024 Apr 8. PMID: 38453411.", + "Intraprocedural C-arm dual-phase cone-beam enhancement patterns correlate with tumor absorbed dose after radioembolization. Bastiaannet R, Lin M, Frey EC, de Jong HWAM. Med Phys. 2024 Apr; 2023 Dec 8. PMID: 38064591.", + "A large open access dataset of brain metastasis 3D segmentations on MRI with clinical and imaging information. Ramakrishnan D, Jekel L, Chadha S, Janas A, Moy H, Maleki N, Sala M, Kaur M, Petersen GC, Merkaj S, von Reppert M, Baid U, Bakas S, Kirsch C, Davis M, Bousabarah K, Holler W, Lin M, Westerhoff M, Aneja S, Memon F, Aboian MS. Sci Data. 2024 Feb 29; 2024 Feb 29. PMID: 38424079.", + "Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8(+) T-Cell Infiltration in Murine Hepatocellular Carcinoma. Shewarega A, Santana JG, Nam D, Berz A, Tefera J, Kahl V, Mishra SK, Coman D, Duncan J, Roberts SJ, Wetter A, Madoff DC, Chapiro J. Radiology. 2024 Feb. PMID: 38349244.", + "Image-guided High-Dose-Rate Brachytherapy for Hepatocellular Carcinoma Could Be the Ultimate Ablation Tool. Chapiro J. Radiology. 2024 Feb. PMID: 38319171.", + "Comparison of volumetric and 2D-based response methods in the PNOC-001 pediatric low-grade glioma clinical trial. von Reppert M, Ramakrishnan D, Brüningk SC, Memon F, Abi Fadel S, Maleki N, Bahar R, Avesta AE, Jekel L, Sala M, Lost J, Tillmanns N, Kaur M, Aneja S, Fathi Kazerooni A, Nabavizadeh A, Lin M, Hoffmann KT, Bousabarah K, Swanson KR, Haas-Kogan D, Mueller S, Aboian MS. Neurooncol Adv. 2024 Jan-Dec; 2023 Dec 27. PMID: 38221978.", + "Correction: Consensus report from the 10th global forum for liver magnetic resonance imaging: multidisciplinary team discussion. Taouli B, Ba-Ssalamah A, Chapiro J, Chhatwal J, Fowler K, Kang TW, Knobloch G, Koh DM, Kudo M, Lee JM, Murakami T, Pinato DJ, Ringe KI, Song B, Tabrizian P, Wang J, Yoon JH, Zeng M, Zhou J, Vilgrain V. Eur Radiol. 2024 Jan. PMID: 37930413.", + "An Interventional Radiologist's Primer of Critical Appraisal of Artificial Intelligence Research. Gaddum O, Chapiro J. J Vasc Interv Radiol. 2024 Jan; 2023 Sep 26. PMID: 37769940.", + "Application of novel PACS-based informatics platform to identify imaging based predictors of CDKN2A allelic status in glioblastomas. Tillmanns N, Lost J, Tabor J, Vasandani S, Vetsa S, Marianayagam N, Yalcin K, Erson-Omay EZ, von Reppert M, Jekel L, Merkaj S, Ramakrishnan D, Avesta A, de Oliveira Santo ID, Jin L, Huttner A, Bousabarah K, Ikuta I, Lin M, Aneja S, Turowski B, Aboian M, Moliterno J. Sci Rep. 2023 Dec 22; 2023 Dec 22. PMID: 38135704.", + "Pulmonary artery pseudoaneurysms: a single-center experience of endovascular occlusion. Fish A, Sailer A, Pollak J, Schlachter T. CVIR Endovasc. 2023 Dec 2; 2023 Dec 2. PMID: 38041788.", + "Hepatic Hypertrophy in Normal and Cirrhotic Livers Following Portal Vein Embolization: Comparative Assessment of 2 Different Embolic Regimens in a Large Animal Model. Kuhn TN, Kahl VH, Wang Y, Berz AM, Shewarega A, Santana JG, Antoch G, Chapiro J, Schlachter T, Madoff DC. J Vasc Interv Radiol. 2023 Dec; 2023 Aug 25. PMID: 37634850.", + "Consensus report from the 10th Global Forum for Liver Magnetic Resonance Imaging: developments in HCC management. Taouli B, Ba-Ssalamah A, Chapiro J, Chhatwal J, Fowler K, Kang TW, Knobloch G, Koh DM, Kudo M, Lee JM, Murakami T, Pinato DJ, Ringe KI, Song B, Tabrizian P, Wang J, Yoon JH, Zeng M, Zhou J, Vilgrain V. Eur Radiol. 2023 Dec; 2023 Jul 27. PMID: 37500964.", + "Consensus report from the 10th global forum for liver magnetic resonance imaging: multidisciplinary team discussion. Taouli B, Ba-Ssalamah A, Chapiro J, Chhatwal J, Fowler K, Kang TW, Knobloch G, Koh DM, Kudo M, Lee JM, Murakami T, Pinato DJ, Ringe KI, Song B, Tabrizian P, Wang J, Yoon JH, Zeng M, Zhou J, Vilgrain V. Eur Radiol. 2023 Dec; 2023 Jul 13. PMID: 37439935.", + "Using Machine Learning to Predict Response to Image-guided Therapies for Hepatocellular Carcinoma. Hsieh C, Laguna A, Ikeda I, Maxwell AWP, Chapiro J, Nadolski G, Jiao Z, Bai HX. Radiology. 2023 Nov. PMID: 37934098.", + "Systematic Literature Review of Machine Learning Algorithms Using Pretherapy Radiologic Imaging for Glioma Molecular Subtype Prediction. Lost J, Verma T, Jekel L, von Reppert M, Tillmanns N, Merkaj S, Petersen GC, Bahar R, Gordem A, Haider MA, Subramanian H, Brim W, Ikuta I, Omuro A, Conte GM, Marquez-Nostra BV, Avesta A, Bousabarah K, Nabavizadeh A, Kazerooni AF, Aneja S, Bakas S, Lin M, Sabel M, Aboian M. AJNR Am J Neuroradiol. 2023 Oct. PMID: 37770204.", + "A Large Open Access Dataset of Brain Metastasis 3D Segmentations with Clinical and Imaging Feature Information. Ramakrishnan D, Jekel L, Chadha S, Janas A, Moy H, Maleki N, Sala M, Kaur M, Petersen GC, Merkaj S, von Reppert M, Baid U, Bakas S, Kirsch C, Davis M, Bousabarah K, Holler W, Lin M, Westerhoff M, Aneja S, Memon F, Aboian MS. ArXiv. 2023 Sep 12; 2023 Sep 12. PMID: 37744461.", + "PACS-integrated machine learning breast density classifier: clinical validation. Lewin J, Schoenherr S, Seebass M, Lin M, Philpotts L, Etesami M, Butler R, Durand M, Heller S, Heacock L, Moy L, Tocino I, Westerhoff M. Clin Imaging. 2023 Sep; 2023 Jul 4. PMID: 37421715.", + "AAPM Task Group Report 238: 3D C-arms with volumetric imaging capability. Supanich M, Siewerdsen J, Fahrig R, Farahani K, Gang GJ, Helm P, Jans J, Jones K, Koenig T, Kuhls-Gilcrist A, Lin M, Riddell C, Ritschl L, Schafer S, Schueler B, Silver M, Timmer J, Trousset Y, Zhang J. Med Phys. 2023 Aug; 2023 Feb 20. PMID: 36710257.", + "Bone Mass Changes Following Percutaneous Radiofrequency Ablation, Osteoplasty, Reinforcement, and Internal Fixation of Periacetabular Osteolytic Metastases. Jiang W, Caruana DL, Dussik CM, Conway D, Latich I, Chapiro J, Lindskog DM, Friedlaender GE, Lee FY. J Clin Med. 2023 Jul 11; 2023 Jul 11. PMID: 37510728.", + "Intravascular Ultrasound-Guided Percutaneous Creation of a Gastric Vein to Cava Shunt in a Patient with Variceal Hemorrhage and Portal Vein Occlusion. Atiles J, Cornman-Homonoff J, Schlachter T. J Vasc Interv Radiol. 2023 Jul. PMID: 37380248.", + "Mesocaval Shunt Creation for Treatment of Bleeding Ectopic Varices in a Patient with Cavernous Transformation of the Portomesenteric System. Megahed A, Atiles J, Schlachter T, Cornman-Homonoff J. Cardiovasc Intervent Radiol. 2023 Jul; 2023 Apr 12. PMID: 37043076.", + "Large left varicocele in a patient with portal hypertension treated via transjugular intrahepatic portosystemic shunt placement and both variceal and varicocele embolization. Megahed A, Schlachter T, Cornman-Homonoff J. BMC Urol. 2023 May 15; 2023 May 15. PMID: 37189067.", + "Predicting tumor recurrence on baseline MR imaging in patients with early-stage hepatocellular carcinoma using deep machine learning. Kucukkaya AS, Zeevi T, Chai NX, Raju R, Haider SP, Elbanan M, Petukhova-Greenstein A, Lin M, Onofrey J, Nowak M, Cooper K, Thomas E, Santana J, Gebauer B, Mulligan D, Staib L, Batra R, Chapiro J. Sci Rep. 2023 May 10; 2023 May 10. PMID: 37165035.", + "Twenty-Seven-Year Retrospective Review of Hemoptysis from Systemic Collaterals Following Pulmonary Arteriovenous Malformation Embolization. Fish A, Chan SM, Pollak J, Schlachter T. Cardiovasc Intervent Radiol. 2023 May; 2023 Apr 13. PMID: 37052715.", + "Explainable AI for Prostate MRI: Don't Trust, Verify. Chapiro J. Radiology. 2023 May; 2023 Apr 11. PMID: 37039689.", + "Experimental VX2 Rabbit Liver Tumor Model in Carbon Tetrachloride-Induced Cirrhosis of the Liver. Santana JG, Shewarega A, Nam D, Kahl V, Madoff DC, Zhang X, Chapiro J. J Vasc Interv Radiol. 2023 Mar; 2022 Dec 5. PMID: 36473611.", + "MR Imaging-Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver. Santana JG, Petukhova-Greenstein A, Gross M, Hyder F, Pekurovsky V, Gottwald LA, Boustani A, Walsh JJ, Kucukkaya AS, Malpani R, Madoff DC, Goldberg SN, Ahmed M, Joshi N, Coman D, Chapiro J. J Vasc Interv Radiol. 2023 Mar; 2022 Nov 21. PMID: 36423815.", + "Comparing 3D, 2.5D, and 2D Approaches to Brain Image Auto-Segmentation. Avesta A, Hossain S, Lin M, Aboian M, Krumholz HM, Aneja S. Bioengineering (Basel). 2023 Feb 1; 2023 Feb 1. PMID: 36829675.", + "Transpleural Systemic Artery-to-Pulmonary Artery Shunts: A Potential Mimicker of Pulmonary Arteriovenous Malformations. Fish A, Chan SM, Pollak J, Schlachter T. J Vasc Interv Radiol. 2023 Feb; 2022 Oct 23. PMID: 36283590.", + "Defining textbook outcome for selective internal radiation therapy of hepatocellular carcinoma: an international expert study. Gregory J, Tselikas L, Allimant C, de Baere T, Bargellini I, Bell J, Bilbao JI, Bouvier A, Chapiro J, Chiesa C, Decaens T, Denys A, Duran R, Edeline J, Garin E, Ghelfi J, Helmberger T, Irani F, Lam M, Lewandowski R, Liu D, Loffroy R, Madoff DC, Mastier C, Salem R, Sangro B, Sze D, Vilgrain V, Vouche M, Guiu B, Ronot M. Eur J Nucl Med Mol Imaging. 2023 Feb; 2022 Oct 25. PMID: 36282299.", + "Machine Learning Models for Prediction of Posttreatment Recurrence in Early-Stage Hepatocellular Carcinoma Using Pretreatment Clinical and MRI Features: A Proof-of-Concept Study. Iseke S, Zeevi T, Kucukkaya AS, Raju R, Gross M, Haider SP, Petukhova-Greenstein A, Kuhn TN, Lin M, Nowak M, Cooper K, Thomas E, Weber MA, Madoff DC, Staib L, Batra R, Chapiro J. AJR Am J Roentgenol. 2023 Feb; 2022 Aug 17. PMID: 35975886.", + "DuDoSS: Deep-learning-based dual-domain sinogram synthesis from sparsely sampled projections of cardiac SPECT. Chen X, Zhou B, Xie H, Miao T, Liu H, Holler W, Lin M, Miller EJ, Carson RE, Sinusas AJ, Liu C. Med Phys. 2023 Jan; 2022 Sep 28. PMID: 36048541.", + "Conventional vs. Drug-Eluting Beads Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma-A Propensity Score Weighted Comparison of Efficacy and Safety. Savic LJ, Chen E, Nezami N, Murali N, Hamm CA, Wang C, Lin M, Schlachter T, Hong K, Georgiades C, Chapiro J, Laage Gaupp FM. Cancers (Basel). 2022 Nov 27; 2022 Nov 27. PMID: 36497329.", + "Clinical implementation of artificial intelligence in neuroradiology with development of a novel workflow-efficient picture archiving and communication system-based automated brain tumor segmentation and radiomic feature extraction. Aboian M, Bousabarah K, Kazarian E, Zeevi T, Holler W, Merkaj S, Cassinelli Petersen G, Bahar R, Subramanian H, Sunku P, Schrickel E, Bhawnani J, Zawalich M, Mahajan A, Malhotra A, Payabvash S, Tocino I, Lin M, Westerhoff M. Front Neurosci. 2022; 2022 Oct 13. PMID: 36312024.", + "Analysis of Tumor Burden as a Biomarker for Patient Survival with Neuroendocrine Tumor Liver Metastases Undergoing Intra-Arterial Therapies: A Single-Center Retrospective Analysis. Miszczuk M, Chapiro J, Do Minh D, van Breugel JMM, Smolka S, Rexha I, Tegel B, Lin M, Savic LJ, Hong K, Georgiades C, Nezami N. Cardiovasc Intervent Radiol. 2022 Oct; 2022 Aug 8. PMID: 35941241.", + "Research Priorities in Percutaneous Image- and Endoscopy-Guided Interventions for Biliary and Gallbladder Diseases: Proceedings from the Society of Interventional Radiology Foundation Multidisciplinary Research Consensus Panel. Riaz A, Trivedi P, Aadam AA, Katariya N, Matsuoka L, Malik A, Gunn AJ, Vezeridis A, Sarwar A, Schlachter T, Harmath C, Srinivasa R, Abi-Jaoudeh N, Singh H. J Vasc Interv Radiol. 2022 Oct; 2022 Jul 7. PMID: 35809805.", + "PET Image Denoising using a Deep-Learning Method for Extremely Obese Patients. Liu H, Yousefi H, Mirian N, Lin M, Menard D, Gregory M, Aboian M, Boustani A, Chen MK, Saperstein L, Pucar D, Kulon M, Liu C. IEEE Trans Radiat Plasma Med Sci. 2022 Sep; 2021 Dec 2. PMID: 37284026.", + "Proceedings from the Society of Interventional Radiology Foundation Research Consensus Panel on Artificial Intelligence in Interventional Radiology: From Code to Bedside. Chapiro J, Allen B, Abajian A, Wood B, Kothary N, Daye D, Bai H, Sedrakyan A, Diamond M, Simonyan V, McLennan G, Abi-Jaoudeh N, Pua B. J Vasc Interv Radiol. 2022 Sep; 2022 Jul 19. PMID: 35871021.", + "Response assessment methods for patients with hepatic metastasis from rare tumor primaries undergoing transarterial chemoembolization. Adam LC, Savic LJ, Chapiro J, Letzen B, Lin M, Georgiades C, Hong KK, Nezami N. Clin Imaging. 2022 Sep; 2022 Jun 26. PMID: 35777239.", + "Cryoablation of Venous Malformations: A Systematic Review. Fish A, Moushey A, Chan SM, Staib L, Marino A, Schlachter T. J Vasc Interv Radiol. 2022 Aug; 2022 Apr 22. PMID: 35469956.", + "Real-time PACS-integrated longitudinal brain metastasis tracking tool provides comprehensive assessment of treatment response to radiosurgery. Cassinelli Petersen G, Bousabarah K, Verma T, von Reppert M, Jekel L, Gordem A, Jang B, Merkaj S, Abi Fadel S, Owens R, Omuro A, Chiang V, Ikuta I, Lin M, Aboian MS. Neurooncol Adv. 2022 Jan-Dec; 2022 Jul 26. PMID: 36043121.", + "Three-Dimensional Quantitative Tumor Response and Survival Analysis of Hepatocellular Carcinoma Patients Who Failed Initial Transarterial Chemoembolization: Repeat or Switch Treatment? Zhao Y, Haroun RR, Sahu S, Schernthaner RE, Smolka S, Lin MD, Hong KK, Georgiades C, Duran R. Cancers (Basel). 2022 Jul 25; 2022 Jul 25. PMID: 35892874.", + "Intraarterial Therapies for the Management of Hepatocellular Carcinoma. Garg T, Shrigiriwar A, Habibollahi P, Cristescu M, Liddell RP, Chapiro J, Inglis P, Camacho JC, Nezami N. Cancers (Basel). 2022 Jul 10; 2022 Jul 10. PMID: 35884412.", + "Safety and feasibility of single use cholecystoscopy for guiding laser or mechanical cholelithotripsy, and mechanical cholelithotomy. Nezami N, Latich I, Chockalingam A, Arici M, Lee J, Perez Lozada JCL, Schlachter T. Diagn Interv Radiol. 2022 Jul. PMID: 35950279.", + "MR Imaging Biomarkers for the Prediction of Outcome after Radiofrequency Ablation of Hepatocellular Carcinoma: Qualitative and Quantitative Assessments of the Liver Imaging Reporting and Data System and Radiomic Features. Petukhova-Greenstein A, Zeevi T, Yang J, Chai N, DiDomenico P, Deng Y, Ciarleglio M, Haider SP, Onyiuke I, Malpani R, Lin M, Kucukkaya AS, Gottwald LA, Gebauer B, Revzin M, Onofrey J, Staib L, Gunabushanam G, Taddei T, Chapiro J. J Vasc Interv Radiol. 2022 Jul; 2022 Apr 20. PMID: 35460887.", + "Translating artificial intelligence from code to bedside: The road towards AI-driven predictive biomarkers for immunotherapy of hepatocellular carcinoma. Chapiro J. J Hepatol. 2022 Jul; 2022 Apr 10. PMID: 35417743.", + "Optimization of the BCLC Staging System for Locoregional Therapy for Hepatocellular Carcinoma by Using Quantitative Tumor Burden Imaging Biomarkers at MRI. Borde T, Nezami N, Laage Gaupp F, Savic LJ, Taddei T, Jaffe A, Strazzabosco M, Lin M, Duran R, Georgiades C, Hong K, Chapiro J. Radiology. 2022 Jul; 2022 Apr 12. PMID: 35412368.", + "Impact of Chemoembolic Regimen on Immune Cell Recruitment and Immune Checkpoint Marker Expression following Transcatheter Arterial Chemoembolization in a VX2 Rabbit Liver Tumor Model. Berz AM, Santana JG, Iseke S, Gross M, Pekurovsky V, Laage Gaupp F, Savic LJ, Borde T, Gottwald LA, Boustani AM, Gebauer B, Lin M, Zhang X, Schlachter T, Madoff DC, Chapiro J. J Vasc Interv Radiol. 2022 Jul; 2022 Mar 26. PMID: 35346859.", + "Direct and indirect strategies of deep-learning-based attenuation correction for general purpose and dedicated cardiac SPECT. Chen X, Zhou B, Xie H, Shi L, Liu H, Holler W, Lin M, Liu YH, Miller EJ, Sinusas AJ, Liu C. Eur J Nucl Med Mol Imaging. 2022 Jul; 2022 Feb 16. PMID: 35169887.", + "Identifying clinically applicable machine learning algorithms for glioma segmentation: recent advances and discoveries. Tillmanns N, Lum AE, Cassinelli G, Merkaj S, Verma T, Zeevi T, Staib L, Subramanian H, Bahar RC, Brim W, Lost J, Jekel L, Brackett A, Payabvash S, Ikuta I, Lin M, Bousabarah K, Johnson MH, Cui J, Malhotra A, Omuro A, Turowski B, Aboian MS. Neurooncol Adv. 2022 Jan-Dec; 2022 Jun 14. PMID: 36071926.", + "Machine Learning Tools for Image-Based Glioma Grading and the Quality of Their Reporting: Challenges and Opportunities. Merkaj S, Bahar RC, Zeevi T, Lin M, Ikuta I, Bousabarah K, Cassinelli Petersen GI, Staib L, Payabvash S, Mongan JT, Cha S, Aboian MS. Cancers (Basel). 2022 May 25; 2022 May 25. PMID: 35681603.", + "Machine Learning Models for Classifying High- and Low-Grade Gliomas: A Systematic Review and Quality of Reporting Analysis. Bahar RC, Merkaj S, Cassinelli Petersen GI, Tillmanns N, Subramanian H, Brim WR, Zeevi T, Staib L, Kazarian E, Lin M, Bousabarah K, Huttner AJ, Pala A, Payabvash S, Ivanidze J, Cui J, Malhotra A, Aboian MS. Front Oncol. 2022; 2022 Apr 22. PMID: 35530302.", + "Artificial intelligence in liver diseases: Improving diagnostics, prognostics and response prediction. Nam D, Chapiro J, Paradis V, Seraphin TP, Kather JN. JHEP Rep. 2022 Apr; 2022 Feb 2. PMID: 35243281.", + "What's Needed to Bridge the Gap Between US FDA Clearance and Real-world Use of AI Algorithms. Lin M. Acad Radiol. 2022 Apr; 2021 Nov 20. PMID: 34794879.", + "Comparison of metabolic and immunologic responses to transarterial chemoembolization with different chemoembolic regimens in a rabbit VX2 liver tumor model. Doemel LA, Santana JG, Savic LJ, Gaupp FML, Borde T, Petukhova-Greenstein A, Kucukkaya AS, Schobert IT, Hamm CA, Gebauer B, Walsh JJ, Rexha I, Hyder F, Lin M, Madoff DC, Schlachter T, Chapiro J, Coman D. Eur Radiol. 2022 Apr; 2021 Oct 31. PMID: 34718844.", + "Machine Learning Applications for Differentiation of Glioma from Brain Metastasis-A Systematic Review. Jekel L, Brim WR, von Reppert M, Staib L, Cassinelli Petersen G, Merkaj S, Subramanian H, Zeevi T, Payabvash S, Bousabarah K, Lin M, Cui J, Brackett A, Mahajan A, Omuro A, Johnson MH, Chiang VL, Malhotra A, Scheffler B, Aboian MS. Cancers (Basel). 2022 Mar 8; 2022 Mar 8. PMID: 35326526.", + "Quantitative Automated Segmentation of Lipiodol Deposits on Cone-Beam CT Imaging Acquired during Transarterial Chemoembolization for Liver Tumors: A Deep Learning Approach. Malpani R, Petty CW, Yang J, Bhatt N, Zeevi T, Chockalingam V, Raju R, Petukhova-Greenstein A, Santana JG, Schlachter TR, Madoff DC, Chapiro J, Duncan J, Lin M. J Vasc Interv Radiol. 2022 Mar; 2021 Dec 16. PMID: 34923098.", + "Improved performance and consistency of deep learning 3D liver segmentation with heterogeneous cancer stages in magnetic resonance imaging. Gross M, Spektor M, Jaffe A, Kucukkaya AS, Iseke S, Haider SP, Strazzabosco M, Chapiro J, Onofrey JA. PLoS One. 2021; 2021 Dec 1. PMID: 34852007.", + "Consensus Guidelines for the Definition of Time-to-Event End Points in Image-guided Tumor Ablation: Results of the SIO and DATECAN Initiative. Puijk RS, Ahmed M, Adam A, Arai Y, Arellano R, de Baère T, Bale R, Bellera C, Binkert CA, Brace CL, Breen DJ, Brountzos E, Callstrom MR, Carrafiello G, Chapiro J, de Cobelli F, Coupé VMH, Crocetti L, Denys A, Dupuy DE, Erinjeri JP, Filippiadis D, Gangi A, Gervais DA, Gillams AR, Greene T, Guiu B, Helmberger T, Iezzi R, Kang TW, Kelekis A, Kim HS, Kröncke T, Kwan S, Lee MW, Lee FT, Lee EW Jr, Liang P, Lissenberg-Witte BI, Lu DS, Madoff DC, Mauri G, Meloni MF, Morgan R, Nadolski G, Narayanan G, Newton I, Nikolic B, Orsi F, Pereira PL, Pua U, Rhim H, Ricke J, Rilling W, Salem R, Scheffer HJ, Sofocleous CT, Solbiati LA, Solomon SB, Soulen MC, Sze D, Uberoi R, Vogl TJ, Wang DS, Wood BJ, Goldberg SN, Meijerink MR. Radiology. 2021 Dec; 2021 Sep 28. PMID: 34581627.", + "Identifying enhancement-based staging markers on baseline MRI in patients with colorectal cancer liver metastases undergoing intra-arterial tumor therapy. Ghani MA, Fereydooni A, Chen E, Letzen B, Laage-Gaupp F, Nezami N, Deng Y, Gan G, Thakur V, Lin M, Papademetris X, Schernthaner RE, Huber S, Chapiro J, Hong K, Georgiades C. Eur Radiol. 2021 Dec; 2021 Jun 1. PMID: 34061209.", + "Longitudinal Analysis of the Effect of Repeated Transarterial Chemoembolization for Liver Cancer on Portal Venous Pressure. Frangakis C, Sohn JH, Bas A, Chapiro J, Schernthaner RE, Lin M, Hamilton JP, Pawlik TM, Hong K, Duran R. Front Oncol. 2021; 2021 Nov 5. PMID: 34804911.", + "Machine Learning-Based Surveillance Strategy after Complete Ablation of Initially Recurrent Hepatocellular Carcinoma: Worth the Risk? Nam D, Chapiro J. J Vasc Interv Radiol. 2021 Nov. PMID: 34717834.", + "Lipiodol Deposition and Washout in Primary and Metastatic Liver Tumors After Chemoembolization. Nezami N, VAN Breugel JMM, Konstantinidis M, Chapiro J, Savic LJ, Miszczuk MA, Rexha I, Lin M, Hong K, Georgiades C. In Vivo. 2021 Nov-Dec. PMID: 34697157.", + "Incidence of Spontaneous Pulmonary AVM Rupture in HHT Patients. Fish A, Henderson K, Moushey A, Pollak J, Schlachter T. J Clin Med. 2021 Oct 14; 2021 Oct 14. PMID: 34682838.", + "Lipiodol as an intra-procedural imaging biomarker for liver tumor response to transarterial chemoembolization: Post-hoc analysis of a prospective clinical trial. Letzen BS, Malpani R, Miszczuk M, de Ruiter QMB, Petty CW, Rexha I, Nezami N, Laage-Gaupp F, Lin M, Schlachter TR, Chapiro J. Clin Imaging. 2021 Oct; 2021 May 18. PMID: 34022765.", + "How COVID-19 kick-started online learning in medical education-The DigiMed study. Stoehr F, Müller L, Brady A, Trilla A, Mähringer-Kunz A, Hahn F, Düber C, Becker N, Wörns MA, Chapiro J, Hinrichs JB, Akata D, Ellmann S, Huisman M, Koff D, Brinkmann S, Bamberg F, Zimmermann O, Traikova NI, Marquardt JU, Chang DH, Rengier F, Auer TA, Emrich T, Muehler F, Schmidberger H, Baeßler B, Dos Santos DP, Kloeckner R. PLoS One. 2021; 2021 Sep 21. PMID: 34547031.", + "Hepatic Radiofrequency Ablation: Monitoring of Ablation-Induced Macrophage Recruitment in the Periablational Rim Using SPION-Enhanced Macrophage-Specific Magnetic Resonance Imaging. Collettini F, Brangsch J, Reimann C, Chapiro J, Savic LJ, Buchholz R, Keller S, Hamm B, Goldberg SN, Makowski MR. Invest Radiol. 2021 Sep 1. PMID: 33787536.", + "Quantitative volumetric assessment of baseline enhancing tumor volume as an imaging biomarker predicts overall survival in patients with glioblastoma. Auer TA, Della Seta M, Collettini F, Chapiro J, Zschaeck S, Ghadjar P, Badakhshi H, Florange J, Hamm B, Budach V, Kaul D. Acta Radiol. 2021 Sep; 2020 Sep 16. PMID: 32938221.", + "Thermal ablation alone vs thermal ablation combined with transarterial chemoembolization for patients with small (<3 cm) hepatocellular carcinoma. Chai NX, Chapiro J, Petukhova A, Gross M, Kucukkaya A, Raju R, Zeevi T, Elbanan M, Lin M, Perez-Lozada JC, Schlachter T, Strazzabosco M, Pollak JS, Madoff DC. Clin Imaging. 2021 Aug; 2021 Feb 11. PMID: 33592550.", + "Anatomy-guided multimodal registration by learning segmentation without ground truth: Application to intraprocedural CBCT/MR liver segmentation and registration. Zhou B, Augenfeld Z, Chapiro J, Zhou SK, Liu C, Duncan JS. Med Image Anal. 2021 Jul; 2021 Mar 21. PMID: 33823397.", + "Sterling Hall of Medicine 333 Cedar Street New Haven, CT 06520-8023", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Yale Larynx Laboratory", + "lab_url": "https://medicine.yale.edu/lab/larynx/", + "research_bio": "INFORMATION FOR The Yale Larynx Laboratory was founded by John A. Kirchner M.D. in 1967. Between 1975-2021, this laboratory has been in continuous operation under the direction of Clarence T. Sasaki M.D., Charles W. Ohse Professor. Since April 2021, Benjamin L. Judson, M.D. has been the laboratory Principal Investigator. Since its start, the Yale Larynx Lab has been funded by the National Institutes of Health and by endowments of grateful patients. Major research groups include: Copy Link Issue 1: A Clinical Review of \"Supraglottic Carcinoma\" Issue 2: A Clinical Review of \"Early Tongue Cancer\" Issue 3: A Clinical Review of \"Zenker’s Diverticulum\" Issue 4: A Clinical Review of \"Osteoradionecrosis\" Issue 5: A Clinical Review of \"Benign Vocal Polyps, Nodules Granulomas: What not to do\" Issue 6: A Clinical Review \"Behold the Inlet Patch!\" Issue 7: A Clinical Review of \"Paraganglioma of the Head and Neck\" Issue 8: A Clinical Review of \"Plunging Ranula: (Another) Great Masquerader\" Issue 9: A Clinical Review of \"Chyle Fistula\" Issue 10: A Clinical Review of \"Cancer of the Anterior Glottic Commissure\" Issue 11: Zenker’s Diverticulum: Toward a Unified Understanding of its Etiopathogenesis\" Issue 12: Management of Radio-recurrent Cancer of the Vocal Cord\" Copy Link", + "publications_page": "https://medicine.yale.edu/lab/larynx/publications/", + "publications": null + }, + { + "lab_name": "Yale PEW", + "lab_url": "https://medicine.yale.edu/lab/pew/", + "research_bio": "INFORMATION FOR Pharmacoepidemiologyis an area of study which focuses on epidemiological methods to evaluate the use and effects of drugs in large populations. The Yale Pharmacoepidemiology Working Group aims to create collaborative opportunities for cultivating and disseminating cutting-edge pharmacoepidemiological methods. The Group aims to provide multi-purpose opportunities to: We will organize the following activities on a regular basis to the group’s Mission: Meet the Co-Leaders of the Working Group, Dr. Zeyan Liew, Dr. Eugenia Chock, and Dr. Haidong Lu. Meet our team of Postdoctoral associates, and our Graduate Student. Learn more about our research projects. Here’s how you can get in touch with us if you have questions and would like to learn more about Yale PEW, the Yale Pharmacoepidemiology Working Group.", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Yale Rheumatology Clinical & Translational Research Laboratory", + "lab_url": "https://medicine.yale.edu/lab/hinchcliff/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Yan Lab", + "lab_url": "https://medicine.yale.edu/lab/yan/", + "research_bio": "INFORMATION FOR Copy Link Our laboratory is interested in understanding how epigenetic aberrations cause cancer and other human diseases. In particular, we focus on the roles and regulatory mechanisms of histone demethylases from the JARID1/KDM5 protein family. These enzymes can remove tri- and di- methyl mark from lysine 4 in histone H3 (H3K4me3/2), the epigenetic marks for transcriptionally active chromatin. Our current data suggest that JARID1A/B enzymes are potential drug targets for cancer therapy and we have identified specific inhibitors of these enzymes. To read more about our research, please see the Yan LabResearchpage. Copy Link", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Yarbrough Laboratory for Head and Neck Oncology", + "lab_url": "https://medicine.yale.edu/lab/yarbrough/", + "research_bio": null, + "publications_page": null, + "publications": null + }, + { + "lab_name": "Yong-Hui Jiang Lab", + "lab_url": "https://medicine.yale.edu/lab/jiang/", + "research_bio": "INFORMATION FOR As a physician scientist, my research program is aiming to uncover the molecular and neurological bases and develop novel therapies for neurodevelopmental (autism spectrum disorder) and neurogenetic disorders caused by genetic or epigenetic defects. We chose the projects that are interesting to us because of the unique clinical presentations of these disorders in clinic and the potential new biology implicated in these disorders. We employ genomics approach to discover the molecular basis of neurodevelopmental and neurogenetic disorders such as autism spectrum disorder, intellectual disability, Phelan-McDermid, Angelman, and Prader-Willi syndrome. We ask important questions how the deficiency of genes such as SHANK2, SHANK3, UBE3A, TET3, HIST1H1E, and SNORD116 lead to the impairment of neurodevelopment and what are the mechanism at molecular and circuit levels. We study these questions using in vitro models of patient IPSC derived neurons and brain organoid and in vivo of mutant mice. We employ multidisciplinary experimental approach of combing molecular, epigenetic, cellular, synaptic physiology, optogenetics, and behavioral techniques. Our ultimate goals are to discover new biology and develop novel therapies for these disorders in humans. We study hard what interests us the most, in the most undisciplined, original as well as enjoyable manner possible. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/jiang/publications/", + "publications": null + }, + { + "lab_name": "Zachary Levine Lab", + "lab_url": "https://medicine.yale.edu/lab/z-levine/", + "research_bio": null, + "publications_page": "https://medicine.yale.edu/lab/z-levine/publications", + "publications": null + }, + { + "lab_name": "Zeyan Liew Lab", + "lab_url": "https://medicine.yale.edu/lab/liew/", + "research_bio": "INFORMATION FOR The Liew lab is focused on conducting human epidemiological research investigating the early environmental influences on health throughout the life-course. We specialize in epidemiologic study designs, perform longitudinal cohort and health record linkage studies, utilize biological samples to investigate exposure-related disease mechanisms, and conduct advanced statistical modeling, including causal inference analyses using real-world data. Meet the Lab’s leader, Dr. Zeyan Liew. Meet our research team of Students, Post-doctoral Associates, Staff, and Visiting Scholars. Learn more about our ongoing and completed research activities.", + "publications_page": null, + "publications": null + }, + { + "lab_name": "Zhang Laboratory of Single-Molecule Biophysics & Biochemistry", + "lab_url": "https://medicine.yale.edu/lab/zhang/", + "research_bio": "INFORMATION FOR Copy Link Copy Link", + "publications_page": "https://medicine.yale.edu/lab/zhang/publications/", + "publications": [ + "Yale School of Medicine /", + "Cell Biology /", + "Research Regulated SNARE Folding and Assembly Membrane Protein Folding, Stability, and Protein-Membrane Interactions Development of New Single-Molecule Methods Molecular Mechanism of the Mechanosensitive Ion Channel NOMPC", + "Regulated SNARE Folding and Assembly", + "Membrane Protein Folding, Stability, and Protein-Membrane Interactions", + "Development of New Single-Molecule Methods", + "Molecular Mechanism of the Mechanosensitive Ion Channel NOMPC", + "Faculty & Researchers Former Members Biology (2012-2016)", + "Former Members Biology (2012-2016)", + "Biology (2012-2016)", + "News", + "Publications", + "About YSM", + "Faculty", + "Staff", + "Students", + "Residents & Fellows", + "Patients", + "Researchers", + "Alumni", + "Research", + "Faculty & Researchers", + "News", + "Publications", + "", + "", + "", + "", + "", + "", + "Genetically encoded mechano-sensors with versatile readouts and compact size. Ren Y, Yang J, Saito T, Glomb O, Kumar A, Mousavi SI, Naughton B, de Fontnouvelle C, Fujita B, Xi Z, Schlieker C, Yogev S, Zhang Y, Berro J. bioRxiv. 2025 Jul 1; 2025 Jul 1. PMID: 39868242.", + "Cross-regulations of two connected domains form a mechanical circuit for steady force transmission during clathrin-mediated endocytosis. Ren Y, Yang J, Fujita B, Zhang Y, Berro J. Cell Rep. 2024 Sep 24; 2024 Sep 13. PMID: 39276354.", + "Nonlinear compliance of NompC gating spring and its implication in mechanotransduction. Wang Y, Jin P, Kumar A, Jan L, Cheng Y, Jan YN, Zhang Y. bioRxiv. 2024 Jun 24; 2024 Jun 24. PMID: 38979198.", + "Lipid osmosis, membrane tension, and other mechanochemical driving forces of lipid flow. Zhang Y, Lin C. Curr Opin Cell Biol. 2024 Jun; 2024 May 31. PMID: 38823338.", + "Lipid osmosis, membrane tension, and other mechanochemical driving forces of lipid flow. Zhang Y, Lin C. bioRxiv. 2024 Apr 28; 2024 Apr 28. PMID: 38260424.", + "Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes. Meijer M, Öttl M, Yang J, Subkhangulova A, Kumar A, Feng Z, van Voorst TW, Groffen AJ, van Weering JRT, Zhang Y, Verhage M. Nat Commun. 2024 Mar 26; 2024 Mar 26. PMID: 38531902.", + "Force redistribution in clathrin-mediated endocytosis revealed by coiled-coil force sensors. Ren Y, Yang J, Fujita B, Jin H, Zhang Y, Berro J. Sci Adv. 2023 Oct 13; 2023 Oct 13. PMID: 37831774.", + "A dynamic template complex mediates Munc18-chaperoned SNARE assembly. Yang J, Jin H, Liu Y, Guo Y, Zhang Y. Proc Natl Acad Sci U S A. 2022 Dec 6; 2022 Dec 1. PMID: 36454760.", + "Energetics, kinetics, and pathways of SNARE assembly in membrane fusion. Zhang Y, Ma L, Bao H. Crit Rev Biochem Mol Biol. 2022 Aug; 2022 Sep 24. PMID: 36151854.", + "Polybasic Patches in Both C2 Domains of Synaptotagmin-1 Are Required for Evoked Neurotransmitter Release. Wu Z, Ma L, Courtney NA, Zhu J, Landajuela A, Zhang Y, Chapman ER, Karatekin E. J Neurosci. 2022 Jul 27; 2022 Jun 14. PMID: 35701163.", + "Stepwise membrane binding of extended synaptotagmins revealed by optical tweezers. Ge J, Bian X, Ma L, Cai Y, Li Y, Yang J, Karatekin E, De Camilli P, Zhang Y. Nat Chem Biol. 2022 Mar; 2021 Dec 16. PMID: 34916620.", + "Quantitative Models of Lipid Transfer and Membrane Contact Formation. Zhang Y, Ge J, Bian X, Kumar A. Contact (Thousand Oaks). 2022; 2022 May 4. PMID: 36120532.", + "Single-Molecule Manipulation Study of Chaperoned SNARE Folding and Assembly with Optical Tweezers. Jin H, Ge J, Yang J, Zhang Y. Methods Mol Biol. 2022. PMID: 36063331.", + "Single-Molecule Optical Tweezers Study of Protein-Membrane Interactions. Ma L, Ge J, Bian X, Zhang Y. Methods Mol Biol. 2022. PMID: 35819776.", + "Single-molecule manipulation of macromolecules on GUV or SUV membranes using optical tweezers. Wang Y, Kumar A, Jin H, Zhang Y. Biophys J. 2021 Dec 21; 2021 Nov 20. PMID: 34813728.", + "Chaperoning SNARE Folding and Assembly. Zhang Y, Hughson FM. Annu Rev Biochem. 2021 Jun 20; 2021 Apr 6. PMID: 33823650.", + "Munc13 binds and recruits SNAP25 to chaperone SNARE complex assembly. Kalyana Sundaram RV, Jin H, Li F, Shu T, Coleman J, Yang J, Pincet F, Zhang Y, Rothman JE, Krishnakumar SS. FEBS Lett. 2021 Feb; 2020 Dec 5. PMID: 33222163.", + "Securing SNAREs for assembly. Zhang Y, Yang J. J Biol Chem. 2020 Jul 24; 2020 Jul 24. PMID: 32709759.", + "Munc13-1 MUN domain and Munc18-1 cooperatively chaperone SNARE assembly through a tetrameric complex. Shu T, Jin H, Rothman JE, Zhang Y. Proc Natl Acad Sci U S A. 2020 Jan 14; 2019 Dec 30. PMID: 31888993.", + "Synaptic vesicle fusion: today and beyond. Brose N, Brunger A, Cafiso D, Chapman ER, Diao J, Hughson FM, Jackson MB, Jahn R, Lindau M, Ma C, Rizo J, Shin YK, Söllner TH, Tamm L, Yoon TY, Zhang Y. Nat Struct Mol Biol. 2019 Aug. PMID: 31384060.", + "Single-Molecule Optical Tweezers Study of Regulated SNARE Assembly. Ma L, Jiao J, Zhang Y. Methods Mol Biol. 2019. PMID: 30317500.", + "Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association. Jiao J, He M, Port SA, Baker RW, Xu Y, Qu H, Xiong Y, Wang Y, Jin H, Eisemann TJ, Hughson FM, Zhang Y. Elife. 2018 Dec 12; 2018 Dec 12. PMID: 30540253.", + "Editorial Overview: Single-Molecule Approaches up to Difficult Challenges in Folding and Dynamics. Zhang Y, Ha T, Marqusee S. J Mol Biol. 2018 Feb 16; 2017 Dec 27. PMID: 29288633.", + "Two Disease-Causing SNAP-25B Mutations Selectively Impair SNARE C-terminal Assembly. Rebane AA, Wang B, Ma L, Qu H, Coleman J, Krishnakumar S, Rothman JE, Zhang Y. J Mol Biol. 2018 Feb 16; 2017 Oct 19. PMID: 29056461.", + "Single-molecule force spectroscopy of protein-membrane interactions. Ma L, Cai Y, Li Y, Jiao J, Wu Z, O'Shaughnessy B, De Camilli P, Karatekin E, Zhang Y. Elife. 2017 Oct 30; 2017 Oct 30. PMID: 29083305.", + "Energetics, kinetics, and pathway of SNARE folding and assembly revealed by optical tweezers. Zhang Y. Protein Sci. 2017 Jul; 2017 Mar 8. PMID: 28097727.", + "Single-Molecule Protein Folding Experiments Using High-Precision Optical Tweezers. Jiao J, Rebane AA, Ma L, Zhang Y. Methods Mol Biol. 2017. PMID: 27844436.", + "Stability, folding dynamics, and long-range conformational transition of the synaptic t-SNARE complex. Zhang X, Rebane AA, Ma L, Li F, Jiao J, Qu H, Pincet F, Rothman JE, Zhang Y. Proc Natl Acad Sci U S A. 2016 Dec 13; 2016 Nov 28. PMID: 27911771.", + "Hidden Markov Modeling with Detailed Balance and Its Application to Single Protein Folding. Zhang Y, Jiao J, Rebane AA. Biophys J. 2016 Nov 15. PMID: 27851936.", + "Regulation of DNA Translocation Efficiency within the Chromatin Remodeler RSC/Sth1 Potentiates Nucleosome Sliding and Ejection. Clapier CR, Kasten MM, Parnell TJ, Viswanathan R, Szerlong H, Sirinakis G, Zhang Y, Cairns BR. Mol Cell. 2016 May 5. PMID: 27153540.", + "α-SNAP Enhances SNARE Zippering by Stabilizing the SNARE Four-Helix Bundle. Ma L, Kang Y, Jiao J, Rebane AA, Cha HK, Xi Z, Qu H, Zhang Y. Cell Rep. 2016 Apr 19; 2016 Apr 7. PMID: 27068468.", + "Structure-Based Derivation of Protein Folding Intermediates and Energies from Optical Tweezers. Rebane AA, Ma L, Zhang Y. Biophys J. 2016 Jan 19. PMID: 26789767.", + "Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis. Ma L, Rebane AA, Yang G, Xi Z, Kang Y, Gao Y, Zhang Y. Elife. 2015 Dec 23; 2015 Dec 23. PMID: 26701912.", + "Kinetically coupled folding of a single HIV-1 glycoprotein 41 complex in viral membrane fusion and inhibition. Jiao J, Rebane AA, Ma L, Gao Y, Zhang Y. Proc Natl Acad Sci U S A. 2015 Jun 2; 2015 May 18. PMID: 26038562.", + "Quantifying and optimizing single-molecule switching nanoscopy at high speeds. Lin Y, Long JJ, Huang F, Duim WC, Kirschbaum S, Zhang Y, Schroeder LK, Rebane AA, Velasco MG, Virrueta A, Moonan DW, Jiao J, Hernandez SY, Zhang Y, Bewersdorf J. PLoS One. 2015; 2015 May 26. PMID: 26011109.", + "Common intermediates and kinetics, but different energetics, in the assembly of SNARE proteins. Zorman S, Rebane AA, Ma L, Yang G, Molski MA, Coleman J, Pincet F, Rothman JE, Zhang Y. Elife. 2014 Sep 1; 2014 Sep 1. PMID: 25180101.", + "High-resolution optical tweezers for single-molecule manipulation. Zhang X, Ma L, Zhang Y. Yale J Biol Med. 2013 Sep; 2013 Sep 20. PMID: 24058311.", + "Single reconstituted neuronal SNARE complexes zipper in three distinct stages. Gao Y, Zorman S, Gundersen G, Xi Z, Ma L, Sirinakis G, Rothman JE, Zhang Y. Science. 2012 Sep 14; 2012 Aug 16. PMID: 22903523.", + "Combined versatile high-resolution optical tweezers and single-molecule fluorescence microscopy. Sirinakis G, Ren Y, Gao Y, Xi Z, Zhang Y. Rev Sci Instrum. 2012 Sep. PMID: 23020384.", + "Single-molecule observation of helix staggering, sliding, and coiled coil misfolding. Xi Z, Gao Y, Sirinakis G, Guo H, Zhang Y. Proc Natl Acad Sci U S A. 2012 Apr 10; 2012 Mar 26. PMID: 22451899.", + "DNA translocation of ATP-dependent chromatin remodeling factors revealed by high-resolution optical tweezers. Zhang Y, Sirinakis G, Gundersen G, Xi Z, Gao Y. Methods Enzymol. 2012. PMID: 22929763.", + "Highly anisotropic stability and folding kinetics of a single coiled coil protein under mechanical tension. Gao Y, Sirinakis G, Zhang Y. J Am Chem Soc. 2011 Aug 17; 2011 Jul 22. PMID: 21707065.", + "The RSC chromatin remodelling ATPase translocates DNA with high force and small step size. Sirinakis G, Clapier CR, Gao Y, Viswanathan R, Cairns BR, Zhang Y. EMBO J. 2011 May 6; 2011 May 6. PMID: 21552204.", + "Anomalous DNA binding by E2 regulatory protein driven by spacer sequence TATA. Xi Z, Zhang Y, Hegde RS, Shakked Z, Crothers DM. Nucleic Acids Res. 2010 Jun; 2010 Feb 25. PMID: 20185566.", + "Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method. Leschziner AE, Saha A, Wittmeyer J, Zhang Y, Bustamante C, Cairns BR, Nogales E. Proc Natl Acad Sci U S A. 2007 Mar 20; 2007 Mar 13. PMID: 17360331.", + "Analysis of in-vivo LacR-mediated gene repression based on the mechanics of DNA looping. Zhang Y, McEwen AE, Crothers DM, Levene SD. PLoS One. 2006 Dec 27; 2006 Dec 27. PMID: 17205140.", + "DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC. Zhang Y, Smith CL, Saha A, Grill SW, Mihardja S, Smith SB, Cairns BR, Peterson CL, Bustamante C. Mol Cell. 2006 Nov 17. PMID: 17188033.", + "Effect of force on mononucleosomal dynamics. Mihardja S, Spakowitz AJ, Zhang Y, Bustamante C. Proc Natl Acad Sci U S A. 2006 Oct 24; 2006 Oct 16. PMID: 17043216.", + "Statistical-mechanical theory of DNA looping. Zhang Y, McEwen AE, Crothers DM, Levene SD. Biophys J. 2006 Mar 15; 2005 Dec 16. PMID: 16361335.", + "Predicting indirect readout effects in protein-DNA interactions. Zhang Y, Xi Z, Hegde RS, Shakked Z, Crothers DM. Proc Natl Acad Sci U S A. 2004 Jun 1; 2004 May 17. PMID: 15148366.", + "High-throughput approach for detection of DNA bending and flexibility based on cyclization. Zhang Y, Crothers DM. Proc Natl Acad Sci U S A. 2003 Mar 18; 2003 Mar 10. PMID: 12629220.", + "Statistical mechanics of sequence-dependent circular DNA and its application for DNA cyclization. Zhang Y, Crothers DM. Biophys J. 2003 Jan. PMID: 12524271.", + "Sterling Hall of Medicine 333 Cedar Street New Haven, CT 06520-8023", + "Calendar", + "Contact Us", + "Intranet", + "Site Editor", + "Accessibility at YSM", + "Nondiscrimination & Title IX", + "Safety & Security", + "Terms & Privacy Statement", + "Yale University", + "Manage Cookie Preferences" + ] + }, + { + "lab_name": "Zhou Research Lab", + "lab_url": "https://medicine.yale.edu/lab/zhou/", + "research_bio": "INFORMATION FOR Our research group focuses on developing translational nanomedicine, gene therapy, and stem cell therapy for treatment of neurological disorders through a unique combination of material science, biology, and engineering. For more information about our research,please check the Research section. Copy Link We have many research opportunities for postdocs, grad students, and medical students interested in using both biology and chemistry to solve medical problems. We are particularly interested in recruiting talents postdoctoral candidates to join our lab at this moment. For more information,please check the postdoctoral opportunities page. Copy Link We thank the following for their current and past support of our research.NIH/NINDS, NIH/NCI, NIH/NIBIB, NIH/NCATS, Connecticut Innovations, American Cancer Society, American Heart Association, Gilbert Family Foundation, American Brain Tumor Association, Patrys Limited, Matthew Larson Foundation, TheCureStartNow Foundation, Swebilius Foundation, VABC Foundation, and B*CURED foundation. We thank the following for their current and past support of our research. NIH/NINDS, NIH/NCI, NIH/NIBIB, NIH/NCATS, Connecticut Innovations, American Cancer Society, American Heart Association, Gilbert Family Foundation, American Brain Tumor Association, Patrys Limited, Matthew Larson Foundation, TheCureStartNow Foundation, Swebilius Foundation, VABC Foundation, and B*CURED foundation. NIH/NINDS, NIH/NCI, NIH/NIBIB, NIH/NCATS, Connecticut Innovations, American Cancer Society, American Heart Association, Gilbert Family Foundation, American Brain Tumor Association, Patrys Limited, Matthew Larson Foundation, TheCureStartNow Foundation, Swebilius Foundation, VABC Foundation, and B*CURED foundation. Copy Link", + "publications_page": "https://medicine.yale.edu/lab/zhou/publications", + "publications": null + } +] \ No newline at end of file diff --git a/yale_physics_faculty_10.json b/yale_physics_faculty_10.json new file mode 100644 index 0000000..290f33d --- /dev/null +++ b/yale_physics_faculty_10.json @@ -0,0 +1,133 @@ +[ + { + "name": "Michael Abbott", + "profile_link": "https://physics.yale.edu/people/michael-abbott", + "title": "Associate Research Scientist", + "office": "YSB-C164", + "email": "michael.abbott@yale.edu", + "phones": [], + "website": "https://machtagroup.yale.edu/", + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3675-1733943781.png?itok=kIXQrctH", + "field_of_study": "BiophysicsTheorist", + "bio": "" + }, + { + "name": "Maren Adnee", + "profile_link": "https://physics.yale.edu/people/maren-adnee", + "title": "Graduate School Student", + "office": "maren.adnee@yale.edu", + "email": "maren.adnee@yale.edu", + "phones": [], + "website": null, + "image_url": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-5455-1750858135.png?itok=S8jFwVed", + "field_of_study": "", + "bio": "" + }, + { + "name": "Charles Ahn", + "profile_link": "https://physics.yale.edu/people/charles-ahn", + "title": "John C. 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Chair of Applied Physics", + "office": "BCT 307", + "email": "sohrab.ismail-beigi@yale.edu", + "extra": "sohrab.ismail-beigi@yale.edu Research Website", + "image": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-120-1721138720.png?itok=FDXTAiQF", + "field_of_study": "Condensed Matter PhysicsTheoristWe study the physics of condensed matter systems, usually the solid state, using first principles or ab initio methods. We solve the quantum mechanical many-body problem of interacting electrons and ions to the best of our abilities, with the fewest approximations possible, and with no adjustable parameters or fitting. The cost is that the calculations must be done numerically and can be quite difficult to perform. The advantage is that the results are generally reliable and accurate, and hence can be compared with confidence to experimental findings to help understand, clarify, and even predict observed physical phenomena." + }, + { + "name": "Akshai Jayakumar Pillai", + "profile_link": "https://physics.yale.edu/people/akshai-jayakumar-pillai", + "title": "Applied Physics Graduate School Student", + "office": "WLW 237", + "email": "akshai.jayakumarpillai@yale.edu", + "extra": "akshai.jayakumarpillai@yale.edu", + "image": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3842-1733944184.png?itok=AlFEYF82", + "field_of_study": "Atomic & Optical Physics" + }, + { + "name": "Michael Jewell", + "profile_link": "https://physics.yale.edu/people/michael-jewell", + "title": "Associate Research Scientist", + "office": "WLC 254C", + "email": "michael.jewell@yale.edu", + "extra": "michael.jewell@yale.edu", + "image": 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Malone Professor of Biomedical Engineering", + "office": "Systems Biology Institute", + "email": "andre.levchenko@yale.edu", + "extra": "andre.levchenko@yale.edu Research Website", + "image": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-3970-1639064558.jpg?itok=-ACdAmfP", + "field_of_study": "BiophysicsExperimentalistQuantitative analysis of signaling pathways regulating biological phenotype: Signaling Pathway Dynamics, Gradient Sensing, Bacteria-Host Interactions, Differentiation of Stem Cells, Control of Cell Shape & Polarity, Hetertypic Cell Interaction, Networks" + }, + { + "name": "Benjia Li", + "profile_link": "https://physics.yale.edu/people/benjia-li", + "title": "Graduate School Student", + "office": "benjia.li@yale.edu", + "email": "benjia.li@yale.edu", + "extra": "", + "image": "https://physics.yale.edu/sites/default/files/styles/people_thumbnail/public/pictures/picture-4778-1760130073.jpg?itok=Yk_miIto", + "field_of_study": 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