diff --git a/README.md b/README.md
index e6777b94..52d5e6f7 100644
--- a/README.md
+++ b/README.md
@@ -331,6 +331,26 @@ The variable `vterm-use-vterm-prompt-detection-method` determines whether to use
 the vterm prompt tracking, if false it use the regexp in
 `vterm-copy-prompt-regexp` to search for the prompt.
 
+## `vterm-enable-manipulate-selection-data-by-osc52`
+
+Vterm support copy text to emacs kill ring and system clipboard by using OSC 52.
+See https://invisible-island.net/xterm/ctlseqs/ctlseqs.html for more info about OSC 52.
+For example: send 'blabla' to kill ring: printf "\033]52;c;$(printf "%s" "blabla" | base64)\a"
+
+tmux can share its copy buffer to terminals bysupporting osc52(like iterm2 xterm),
+you can enable this feature for tmux by :
+set -g set-clipboard on         #osc 52 copy paste share with iterm
+set -ga terminal-overrides ',xterm*:XT:Ms=\E]52;%p1%s;%p2%s\007'
+set -ga terminal-overrides ',screen*:XT:Ms=\E]52;%p1%s;%p2%s\007'
+
+The clipboard querying/clearing functionality offered by OSC 52 is not implemented here,
+And for security reason, this feature is disabled by default."
+
+This feature need the new way of handling strings with a struct `VTermStringFragment`
+in libvterm. You'd better compile emacs-libvterm with `cmake -DUSE_SYSTEM_LIBVTERM=no ..`.
+If you don't do that, when  the content you want to copied is too long, it would be truncated
+by bug of libvterm.
+
 ## `vterm-buffer-name-string`
 
 When `vterm-buffer-name-string` is not nil, vterm renames automatically its own
diff --git a/elisp.c b/elisp.c
index 43f0ef94..8b4dfedc 100644
--- a/elisp.c
+++ b/elisp.c
@@ -54,6 +54,7 @@ emacs_value Fvterm_invalidate;
 emacs_value Feq;
 emacs_value Fvterm_get_color;
 emacs_value Fvterm_eval;
+emacs_value Fvterm_selection;
 
 /* Set the function cell of the symbol named NAME to SFUN using
    the 'fset' function.  */
@@ -194,3 +195,9 @@ void vterm_invalidate(emacs_env *env) {
 emacs_value vterm_eval(emacs_env *env, emacs_value string) {
   return env->funcall(env, Fvterm_eval, 1, (emacs_value[]){string});
 }
+
+emacs_value vterm_selection(emacs_env *env, emacs_value selection_target,
+                            emacs_value selection_data) {
+  return env->funcall(env, Fvterm_selection, 2,
+                      (emacs_value[]){selection_target, selection_data});
+}
diff --git a/elisp.h b/elisp.h
index d59f182a..2fd64f41 100644
--- a/elisp.h
+++ b/elisp.h
@@ -57,6 +57,7 @@ extern emacs_value Fvterm_invalidate;
 extern emacs_value Feq;
 extern emacs_value Fvterm_get_color;
 extern emacs_value Fvterm_eval;
+extern emacs_value Fvterm_selection;
 
 // Utils
 void bind_function(emacs_env *env, const char *name, emacs_value Sfun);
@@ -90,5 +91,7 @@ void set_directory(emacs_env *env, emacs_value string);
 void vterm_invalidate(emacs_env *env);
 emacs_value vterm_get_color(emacs_env *env, int index);
 emacs_value vterm_eval(emacs_env *env, emacs_value string);
+emacs_value vterm_selection(emacs_env *env, emacs_value selection_target,
+                            emacs_value selection_data);
 
 #endif /* ELISP_H */
diff --git a/vterm-module.c b/vterm-module.c
index c99ed02d..c976e950 100644
--- a/vterm-module.c
+++ b/vterm-module.c
@@ -578,6 +578,15 @@ static void term_redraw(Term *term, emacs_env *env) {
     free(term->elisp_code);
     term->elisp_code = NULL;
   }
+  if (term->selection_data) {
+    emacs_value selection_target = env->make_string(
+        env, &term->selection_target[0], strlen(&term->selection_target[0]));
+    emacs_value selection_data = env->make_string(env, term->selection_data,
+                                                  strlen(term->selection_data));
+    vterm_selection(env, selection_target, selection_data);
+    free(term->selection_data);
+    term->selection_data = NULL;
+  }
 
   term->is_invalidated = false;
 }
@@ -938,6 +947,10 @@ void term_finalize(void *object) {
     free(term->cmd_buffer);
     term->cmd_buffer = NULL;
   }
+  if (term->selection_data) {
+    free(term->selection_data);
+    term->selection_data = NULL;
+  }
 
   for (int i = 0; i < term->lines_len; i++) {
     if (term->lines[i] != NULL) {
@@ -995,6 +1008,37 @@ static int handle_osc_cmd_51(Term *term, char subCmd, char *buffer) {
   }
   return 0;
 }
+static int handle_osc_cmd_52(Term *term, char *buffer) {
+  /* OSC 52 ; Pc ; Pd BEL */
+  /* Manipulate Selection Data  */
+  /* https://invisible-island.net/xterm/ctlseqs/ctlseqs.html */
+  /* test by printf "\033]52;c;$(printf "%s" "blabla" | base64)\a" */
+
+  for (int i = 0; i < SELECTION_TARGET_MAX; i++) { /* reset Pc */
+    term->selection_target[i] = 0;
+  }
+  int selection_target_idx = 0;
+  size_t cmdlen = strlen(buffer);
+
+  for (int i = 0; i < cmdlen; i++) {
+    /* OSC 52 ; Pc ; Pd BEL */
+    if (buffer[i] == ';') { /* find the second ";" */
+      term->selection_data = malloc(cmdlen - i);
+      strcpy(term->selection_data, &buffer[i + 1]);
+      break;
+    }
+    if (selection_target_idx < SELECTION_TARGET_MAX) {
+      /* c , p , q , s , 0 , 1 , 2 , 3 , 4 , 5 , 6 , and 7 */
+      /* for clipboard, primary, secondary, select, or cut buffers 0 through 7
+       * respectively */
+      term->selection_target[selection_target_idx] = buffer[i];
+      selection_target_idx++;
+    } else { /* len of Pc should not >12 just ignore this cmd,am I wrong? */
+      return 0;
+    }
+  }
+  return 1;
+}
 static int handle_osc_cmd(Term *term, int cmd, char *buffer) {
   if (cmd == 51) {
     char subCmd = '0';
@@ -1002,7 +1046,10 @@ static int handle_osc_cmd(Term *term, int cmd, char *buffer) {
       return 0;
     }
     subCmd = buffer[0];
+    /* ++ skip the subcmd char */
     return handle_osc_cmd_51(term, subCmd, ++buffer);
+  } else if (cmd == 52) {
+    return handle_osc_cmd_52(term, buffer);
   }
   return 0;
 }
@@ -1019,10 +1066,13 @@ static int osc_callback(const char *command, size_t cmdlen, void *user) {
   } else if (cmdlen > 4 && buffer[0] == '5' && buffer[1] == '1' &&
              buffer[2] == ';' && buffer[3] == 'E') {
     return handle_osc_cmd_51(term, 'E', &buffer[4]);
+  } else if (cmdlen > 4 && buffer[0] == '5' && buffer[1] == '2' &&
+             buffer[2] == ';') {
+    /* OSC 52 ; Pc ; Pd BEL */
+    return handle_osc_cmd_52(term, &buffer[3]);
   }
   return 0;
 }
-
 static VTermParserCallbacks parser_callbacks = {
     .text = NULL,
     .control = NULL,
@@ -1042,10 +1092,16 @@ static int osc_callback(int cmd, VTermStringFragment frag, void *user) {
   /* "51;E" executes elisp code */
   /* The elisp code is executed in term_redraw */
 
+  /* "52;[cpqs01234567];data" Manipulate Selection Data */
+  /* I think libvterm has bug ,sometimes when the data is long enough ,the final
+   * fragment is missed */
+  /* printf "\033]52;c;$(printf "%s" $(ruby -e 'print "x"*999999')|base64)\a"
+   */
+
   Term *term = (Term *)user;
 
   if (frag.initial) {
-     /* drop old fragment,because this is a initial fragment */
+    /* drop old fragment,because this is a initial fragment */
     if (term->cmd_buffer) {
       free(term->cmd_buffer);
       term->cmd_buffer = NULL;
@@ -1128,6 +1184,7 @@ emacs_value Fvterm_new(emacs_env *env, ptrdiff_t nargs, emacs_value args[],
   term->directory_changed = false;
   term->elisp_code = NULL;
   term->elisp_code_changed = false;
+  term->selection_data = NULL;
 
   term->cmd_buffer = NULL;
 
@@ -1337,6 +1394,8 @@ int emacs_module_init(struct emacs_runtime *ert) {
   Fvterm_get_color =
       env->make_global_ref(env, env->intern(env, "vterm--get-color"));
   Fvterm_eval = env->make_global_ref(env, env->intern(env, "vterm--eval"));
+  Fvterm_selection =
+      env->make_global_ref(env, env->intern(env, "vterm--selection"));
 
   // Exported functions
   emacs_value fun;
diff --git a/vterm-module.h b/vterm-module.h
index 2b585411..63308275 100644
--- a/vterm-module.h
+++ b/vterm-module.h
@@ -38,6 +38,10 @@ enum {
   VTERM_PROP_CURSOR_NOT_VISIBLE = 5,
 };
 
+/*  c , p , q , s , 0 , 1 , 2 , 3 , 4 , 5 , 6 , and 7  */
+/* clipboard, primary, secondary, select, or cut buffers 0 through 7 */
+#define SELECTION_TARGET_MAX 12
+
 typedef struct Cursor {
   int row, col;
   int cursor_type;
@@ -75,6 +79,11 @@ typedef struct Term {
   char *elisp_code;
   bool elisp_code_changed;
 
+  /*  c , p , q , s , 0 , 1 , 2 , 3 , 4 , 5 , 6 , and 7  */
+  /* clipboard, primary, secondary, select, or cut buffers 0 through 7 */
+  char selection_target[SELECTION_TARGET_MAX];
+  char *selection_data;
+
   /* the size of dirs almost = window height, value = directory of that line */
   LineInfo **lines;
   int lines_len;
diff --git a/vterm.el b/vterm.el
index f1cd6637..2c7a216d 100644
--- a/vterm.el
+++ b/vterm.el
@@ -269,6 +269,22 @@ information on the how to configure the shell."
   :type 'string
   :group 'vterm)
 
+(defcustom vterm-enable-manipulate-selection-data-by-osc52 nil
+  "Support OSC 52 MANIPULATE SELECTION DATA.
+
+Support copy text to emacs kill ring and system clipboard by using OSC 52.
+For example: send base64 encoded 'foo' to kill ring: echo -en '\e]52;c;Zm9v\a',
+tmux can share its copy buffer to terminals by supporting osc52(like iterm2 xterm),
+you can enable this feature for tmux by :
+set -g set-clipboard on         #osc 52 copy paste share with iterm
+set -ga terminal-overrides ',xterm*:XT:Ms=\E]52;%p1%s;%p2%s\007'
+set -ga terminal-overrides ',screen*:XT:Ms=\E]52;%p1%s;%p2%s\007'
+
+The clipboard querying/clearing functionality offered by OSC 52 is not implemented here,
+And for security reason, this feature is disabled by default."
+  :type 'boolean
+  :group 'vterm)
+
 ;; TODO: Improve doc string, it should not point to the readme but it should
 ;;       be self-contained.
 (defcustom vterm-eval-cmds '(("find-file" find-file)
@@ -922,6 +938,31 @@ Argument BUFFER the terminal buffer."
             (when (cl-member (selected-window) windows :test #'eq)
               (set-window-hscroll (selected-window) 0))))))))
 
+(defun vterm--selection (targets data)
+  "OSC 52 Manipulate Selection Data.
+Search Manipulate Selection Data in
+ https://invisible-island.net/xterm/ctlseqs/ctlseqs.html ."
+  (when vterm-enable-manipulate-selection-data-by-osc52
+    (unless (or (string-equal data "?")
+                (string-empty-p data))
+      (let ((decoded-data (decode-coding-string
+                           (base64-decode-string data) locale-coding-system))
+            (select-enable-clipboard select-enable-clipboard)
+            (select-enable-primary select-enable-primary))
+        ;; https://invisible-island.net/xterm/ctlseqs/ctlseqs.html
+        ;; c , p , q , s , 0 , 1 , 2 , 3 , 4 , 5 , 6 , and 7
+        ;; clipboard, primary, secondary, select, or cut buffers 0 through 7
+        (unless (string-empty-p targets)
+          (setq select-enable-clipboard nil)
+          (setq select-enable-primary nil))
+        (when (cl-find ?c targets)
+          (setq select-enable-clipboard t))
+        (when (cl-find ?p targets)
+          (setq select-enable-primary t))
+
+        (kill-new decoded-data)
+        (message "kill-ring is updated by vterm OSC 52(Manipulate Selection Data)")))))
+
 ;;; Entry Points
 
 ;;;###autoload