diff --git a/source/_magnifier/__init__.py b/source/_magnifier/__init__.py
index f742dd6f1ea..b4cbed790f2 100644
--- a/source/_magnifier/__init__.py
+++ b/source/_magnifier/__init__.py
@@ -11,6 +11,7 @@
 from typing import TYPE_CHECKING
 from .config import getMagnifiedView
 from .utils.types import MagnifiedView
+from .fullscreenMagnifier import FullScreenMagnifier
 
 if TYPE_CHECKING:
 	from .magnifier import Magnifier
@@ -119,6 +120,9 @@ def terminate() -> None:
 	Called when NVDA shuts down.
 	"""
 	global _magnifier
-	if _magnifier and _magnifier._isActive:
-		_magnifier._stopMagnifier()
+	if _magnifier:
+		if _magnifier._isActive:
+			_magnifier._stopMagnifier()
+		if isinstance(_magnifier, FullScreenMagnifier):
+			_magnifier._finalUninitializeNativeMagnification()
 	_magnifier = None
diff --git a/source/_magnifier/fullscreenMagnifier.py b/source/_magnifier/fullscreenMagnifier.py
index b9d1cd697d3..eb9615fbf70 100644
--- a/source/_magnifier/fullscreenMagnifier.py
+++ b/source/_magnifier/fullscreenMagnifier.py
@@ -40,6 +40,7 @@ def __init__(self):
 		self._currentCoordinates = Coordinates(0, 0)
 		self._spotlightManager = SpotlightManager(self)
 		self._displaySize = Size(self._displayOrientation.width, self._displayOrientation.height)
+		self._nativeApiInitialized: bool = False
 		self._startMagnifier()
 
 	@Magnifier.filterType.setter
@@ -89,26 +90,25 @@ def _startMagnifier(self) -> None:
 
 	def _initializeNativeMagnification(self) -> None:
 		"""
-		Initialize the Magnification API and verify it is fully usable.
-
-		Raises OSError if MagInitialize fails or if the initial fullscreen
-		transform fails (e.g. Windows Magnifier already holds the API). If
-		MagSetFullscreenTransform fails after a successful MagInitialize, this
-		method uninitializes the native magnification API before re-raising.
-		Failures from MagInitialize are propagated to the caller.
-		"""
-		magnification.MagInitialize()
-		log.debug("Magnification API initialized")
+		Initialize the Magnification API and apply the initial fullscreen transform.
+		MagInitialize is called only once per instance lifetime: the Initialize →
+		Uninitialize → Initialize cycle within the same process causes
+		MagSetFullscreenTransform to fail with WinError 0. To avoid this, the API
+		stays initialized between magnifier toggles and is only uninitialized on
+		NVDA shutdown via _finalUninitializeNativeMagnification.
+		Raises OSError if MagInitialize fails or if MagSetFullscreenTransform fails
+		(e.g. Windows Magnifier already holds the API).
+		"""
+		if not self._nativeApiInitialized:
+			magnification.MagInitialize()
+			self._nativeApiInitialized = True
+			log.debug("Magnification API initialized")
 		# Applying the first real update verifies the API is usable without
 		# briefly jumping the magnified view to the top-left corner.
-		try:
-			coordinates = self._getCoordinatesForMode(self._currentCoordinates)
-			# Save screen position for mode continuity, matching _doUpdate.
-			self._lastScreenPosition = coordinates
-			self._fullscreenMagnifier(coordinates)
-		except OSError:
-			self._uninitializeNativeMagnification()
-			raise
+		coordinates = self._getCoordinatesForMode(self._currentCoordinates)
+		# Save screen position for mode continuity, matching _doUpdate.
+		self._lastScreenPosition = coordinates
+		self._fullscreenMagnifier(coordinates)
 
 	def _doUpdate(self):
 		"""
@@ -123,11 +123,20 @@ def _doUpdate(self):
 
 	def _stopMagnifier(self) -> None:
 		"""
-		Stop the Full-screen magnifier using windows DLL
+		Stop the Full-screen magnifier using windows DLL.
+		The native API is intentionally kept initialized to allow clean restarts;
+		it is only uninitialized on NVDA shutdown via _finalUninitializeNativeMagnification.
 		"""
 		super()._stopMagnifier()
 		self._resetMagnification()
+
+	def _finalUninitializeNativeMagnification(self) -> None:
+		"""
+		Uninitialize the Magnification API.
+		Must be called after _stopMagnifier, which already resets the transform.
+		"""
 		self._uninitializeNativeMagnification()
+		self._nativeApiInitialized = False
 
 	@trackNativeMagnifierErrors
 	def _resetMagnification(self) -> None:
@@ -172,6 +181,7 @@ def _attemptRecovery(self) -> None:
 		)
 
 		self._uninitializeNativeMagnification()
+		self._nativeApiInitialized = False
 
 		try:
 			# _initializeNativeMagnification also probes MagSetFullscreenTransform,