Inquiry Regarding Memote's Support for Enzyme-Constrained Metabolic Model Evaluation

[wakaka0618]

Dear Memote Development Team,

I hope this message finds you well. I am currently working with enzyme-constrained metabolic models and was wondering if Memote supports the evaluation of these types of models. Specifically, I am interested in knowing whether Memote's current suite of tests can handle the additional complexities introduced by enzyme kinetics and protein constraints within these models.

If Memote does support enzyme-constrained models, are there any specific guidelines or modifications that I should be aware of to ensure accurate assessments?

[Midnighter]

Hi there,

Thank you for your interest. MEMOTE was not designed with enzyme constrained models in mind. However, there are many tests that should anyway apply, like checking annotation. I can't tell you which tests will work without trying, as it also depends on how the enzyme constraints were implemented.