Cells are classified into tumor or stroma classes based on antigen expression levels of each cell. Data from 31 different antigens are organized as follows:
| CCR3 | CD103 | ... | Class |
|---|---|---|---|
| 0.115 | 0.217 | ... | stroma |
| 1.216 | 0.412 | ... | stroma |
| 0.662 | 0.326 | ... | tumor |
The following antigens are available:
['CCR3', 'CD103', 'CD11B', 'CD141', 'CD163', 'CD19', 'CD3', 'CD31', 'CD4', 'CD45RA', 'CD56', 'CD62L', 'CD8', 'CXCR3', 'EPCAM', 'FAP', 'FOXP3', 'GFAP', 'GZMB', 'IL10', 'INOS', 'KI67', 'LOX1', 'TRYPTASE', 'MPO', 'MUC1', 'PD1', 'PDL1', 'PRG2', 'SMA', 'VIMENTIN']
A total of 268074 cells were identified from 6 patients on multiplexed whole slide images. Regions were identified as tumor or stroma by pathologists. Fitting random forest models, antigens are ranked per feature importance as reported by the best models. The scripts analyze the following tests on all patients and individual patients:
all antigensall antigens but MUC1, KI67, EPCAMall but top K antigens by intensity meansonly top K antigens found after ranking all antigens
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